CN105435294A - Bandage for diminishing inflammation and stopping bleeding of injury and preparation method thereof - Google Patents
Bandage for diminishing inflammation and stopping bleeding of injury and preparation method thereof Download PDFInfo
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- CN105435294A CN105435294A CN201510994611.7A CN201510994611A CN105435294A CN 105435294 A CN105435294 A CN 105435294A CN 201510994611 A CN201510994611 A CN 201510994611A CN 105435294 A CN105435294 A CN 105435294A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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Abstract
The invention discloses bandage for diminishing inflammation and stopping bleeding of an injury and a preparation method thereof. The bandage is prepared from the following main raw materials in parts by weight: 24-30 parts of polyurethane prepolymer, 4-7 parts of root of pseudo-ginseng, 8-12 parts of rhizoma typhonii, 4-8 parts of notopterygium root, 5-10 parts of dandelion, 10-13 parts of barberry root or stem, 6-9 parts of Radix Sanguisorbae, 8-11 parts of Japanese beauty-berry leaf, 5-10 parts of catechu, 6-9 parts of cacumen biotae, 10-14 parts of rhizoma bletillae and a proper amount of defoaming agent. The bandage has no toxic or side effect, good air permeability, strong moisture absorption, no negative stimulation on human bodies and excellent biocompatibility, has effects of stopping bleeding, sterilizing, diminishing inflammation, relieving pain, diminishing swelling, promoting granulation and the like, can be used for quickly stopping bleeding so as to relieve pains of patients, prevent muscle contraction and injury infection, accelerate healing and improve swelling. The bandage is convenient for movement of bones at the injury position, is beneficial to function recovery, is comfortable for patients, and is convenient to use.
Description
Technical field
The present invention relates to field of medical materials, particularly relate to a kind of binder for wound anti-inflammation hemostasia and preparation method.
Background technology
In wound and operation, tourniquet bandage use is proper can prevent life-threatening massive hemorrhage immediately, and improper use but may cause tissue and nerve injury, occurs multiple complications.Over the years, attach great importance to the development that hemostasis equipment arrives in the world always.Binder, as the typical products of medical textile, can prevent wound from injuring again, properly regulate the temperature and humidity of wound, reduces complication and prevents the infection phenomenon in normal healing process, and make wounded body feel comfortable.The research of wound physiologist shows, wound keeps certain humidity to be conducive to the diffusion of Skin Cell, the healing of accelerated in wounds.In wound healing process, wet environment can prevent contraction from overrunning and scabbing, and a large amount of body fluid that wound oozes out at first easily make bacterial reproduction and cause infecting, and therefore effectively absorb these body fluid, keep a gnotobasis to be very necessary in wound.So the following effect of tool answered by desirable binder: (1) keeps wet environment with the healing of accelerated in wounds in wound.(2) liquid and noxious substance that wound oozes out can be removed.(3) certain elasticity must be had.(4) keep wound not infected.(5) nontoxic, inviscid, binder does not produce new wound when dismantling.(6) stand various disinfecting and never degenerate.
Application publication number CN105056287A(application number 201510453622.4) Chinese patent literature disclose a kind of acaricide antibacterial medical binder, the raw material of this medical bandage is formed by paddy gastral cavity azelon, chitin fiber and cotton fiber blending, and the weight ratio of described paddy gastral cavity azelon, chitin fiber and cotton fiber material is paddy gastral cavity azelon: cotton fiber=10-15:20-30:30-60.Application publication number CN103405802A(application number 201210240496.0) Chinese patent literature disclose a kind of preparation method with the medical polyurethane binder of sterilizing and itch-relieving, comprise the steps: chitosan microball or the chitosan quaternary ammonium salt first preparing base polyurethane prepolymer for use as He there is sterilizing and itch-relieving function, again base polyurethane prepolymer for use as is evenly coated in Ji Bushang, the Ji Bu being coated with base polyurethane prepolymer for use as carries out coating chitosan microball or chitosan quaternary ammonium salt again under the guiding of guide.Application publication number CN104264485A(application number 201410477406.9) Chinese patent literature disclose a kind of preparation method being coated with the medical bandage of polyurethane resin performed polymer, comprise the following steps: a, add aromatic diisocyanate, dehydrant in a kettle., polyether Glycols, polyether-tribasic alcohol, high molecular weight polyethylene glycol, defoamer, white carbon, lubricant, catalyst is added again after stirring, be warming up to 75 DEG C of insulations, then be down to room temperature, then obtain base polyurethane prepolymer for use as; B, pulverous nanometer particle, zinc oxide, far-infrared emission material are added in dehydrated alcohol and coupling agent solution, dryly after fully stirring also grind, then obtain functive powder; C, join in base polyurethane prepolymer for use as by functive powder, under nitrogen protection condition, abundant stirring reaction, then obtain polyurethane resin performed polymer; D, polyurethane resin performed polymer is evenly coated in Ji Bushang, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the medical bandage being coated with polyurethane resin performed polymer.At present, China's hemostatic material is of less types, and function singleness.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of binder for wound anti-inflammation hemostasia and preparation method.Products obtained therefrom of the present invention has no side effect, good permeability, and hygroscopicity is strong, and to human body without pessimal stimulation, there is good bio-compatibility, there is the effects such as hemostasis, sterilization, antiinflammatory, pain relieving, detumescence and promoting granulation, hemostasis rapidly, not only can alleviate the misery of patient, prevent muscle contraction, can also wound infection be prevented, healing acceleration, improve swelling, be convenient to injury skeleton motion, be conducive to the recovery of function, patient uses comfortable, easy to use.
Technical scheme of the present invention is:
For a binder for wound anti-inflammation hemostasia, take off the primary raw material stating weight proportion and be prepared from: base polyurethane prepolymer for use as 24-30, Radix Notoginseng 4-7, Rhizoma Typhonii 8-12, Rhizoma Et Radix Notopterygii 4-8, Herba Taraxaci 5-10, Radix Berberidis Amurensis 10-13, Radix Sanguisorbae 6-9, Folium Callicarpae Formosanae 8-11, catechu 5-10, Cacumen Platycladi 6-9, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-14, defoamer is appropriate.
For a binder for wound anti-inflammation hemostasia, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: base polyurethane prepolymer for use as 26-29, Radix Notoginseng 5-6, Rhizoma Typhonii 9-11, Rhizoma Et Radix Notopterygii 5-7, Herba Taraxaci 6-8, Radix Berberidis Amurensis 11-12, Radix Sanguisorbae 7-8, Folium Callicarpae Formosanae 9-10, catechu 7-9, Cacumen Platycladi 7-8, Pseudobulbus Bletillae (Rhizoma Bletillae) 11-13, defoamer is appropriate.
For a binder for wound anti-inflammation hemostasia, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: base polyurethane prepolymer for use as 27, Radix Notoginseng 5.5, Rhizoma Typhonii 10, Rhizoma Et Radix Notopterygii 6, Herba Taraxaci 7, Radix Berberidis Amurensis 11.5, Radix Sanguisorbae 7.5, Folium Callicarpae Formosanae 9.5, catechu 8, Cacumen Platycladi 7.5, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, defoamer is appropriate.
The preparation method of the above-mentioned binder for wound anti-inflammation hemostasia is:
(1) get Semen Glycines, the amount of Semen Glycines is the 1/6-1/2 of Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight, puts into pot and makes popular, add Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae stir together with Pseudobulbus Bletillae (Rhizoma Bletillae), be as the criterion so that bean is ripe, take out, sieve de-etiolation bean, is ground into fine powder;
(2) get Rhizoma Et Radix Notopterygii, Herba Taraxaci, Folium Callicarpae Formosanae and Cacumen Platycladi, removing impurity, adding 13 times amount volume fractions is the ethanol water of 55%-75%, room temperature lixiviate 3 times, each 8 hours, merges three extracting solution, decompression recycling ethanol is also condensed into the thick paste that relative density is 1.28-1.34, dry, pulverize into coarse powder, cross 40 mesh sieves, add the vinegar of coarse powder weight 1/6-1/2, stir evenly, vexed 4-6 hour, dry, pulverize into fine powder;
(3) get catechu, be ground into coarse powder, be placed in 50 DEG C of vacuum drying ovens dry 12 hours, be ground into fine powder;
(4) step (1), step (2) and step (3) gained are mixed, add base polyurethane prepolymer for use as and defoamer, the consumption of defoamer is the 0.2%-0.55% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight, 30-45 DEG C of temperature, under nitrogen protection condition, stir 2.5-4.5 hour, obtain coating agent;
(5) step (4) gained coating agent is evenly coated in Ji Bushang, coating agent consumption is 38-62g on every square of mesityl cloth, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the binder for wound anti-inflammation hemostasia.
Preferably be in step (1), the amount of Semen Glycines is the 1/5-1/3 of Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight.
Preferably be in step (2), adding 13 times amount volume fractions is the ethanol water of 60%-70%.
Preferably be in step (2), decompression recycling ethanol is also condensed into the thick paste that relative density is 1.3-1.33.
Preferably be, in step (2), to add the vinegar of coarse powder weight 1/5-1/3.
Preferably be in step (2), vexed 4.5-5.5 hour.
Preferably be in step (4), described base polyurethane prepolymer for use as is purchased from Shanghai He Cheng macromolecule Science and Technology Ltd. or Shandong Rayleigh new material company limited.
Preferably be in step (4), the consumption of defoamer is the 0.25%-0.4% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight.
Preferably be in step (4), 32-40 DEG C of temperature.
Preferably be in step (4), stir 3-4 hour.
Preferably be in step (5), coating agent consumption is 43-54g on every square of mesityl cloth.
Be more preferably, in step (1) amount of Semen Glycines be Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight 1/4.
Be more preferably, adding 13 times amount volume fractions in step (2) is the ethanol water of 65%
Be more preferably, decompression recycling ethanol in step (2) is also condensed into the thick paste that relative density is 1.32.
Be more preferably, in step (2), add the vinegar of coarse powder weight 1/4.
Be more preferably, in step (2) vexed 5 hours.
Be more preferably, described in step (4), base polyurethane prepolymer for use as is purchased from Shandong Rayleigh new material company limited.
Be more preferably, in step (4), the consumption of defoamer is 0.35% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight.
Be more preferably, 35 DEG C of temperature in step (4).
Be more preferably, stir 3.5 hours in step (4).
Be more preferably, step (5) floating coat agent consumption is 48g on every square of mesityl cloth.
Binder preparation method for wound anti-inflammation hemostasia provided by the invention is simple, and patient uses comfortable, easy to use.In addition, excellent results of the present invention also shows:
1, products obtained therefrom good permeability of the present invention, hygroscopicity is strong, and to human body without pessimal stimulation;
2, have the effects such as good hemostasis, sterilization, antiinflammatory, pain relieving, detumescence and promoting granulation, hemostasis rapidly, not only can subtract
The misery of hypopathia people, prevents muscle contraction, can also prevent wound infection, healing acceleration, shortens treatment time, improves swelling, be convenient to injury skeleton motion, be conducive to the recovery of function;
3, use safety, and without any side effects, there is good bio-compatibility;
4, when binder is dismantled, not easily wound is produced.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 one kinds of binders for wound anti-inflammation hemostasia, the primary raw material getting following weight parts is prepared from (every part is 360g): base polyurethane prepolymer for use as 24 parts, Radix Notoginseng 4 parts, Rhizoma Typhonii 8 parts, Rhizoma Et Radix Notopterygii 4 parts, Herba Taraxaci 5 parts, Radix Berberidis Amurensis 10 parts, Radix Sanguisorbae 6 parts, Folium Callicarpae Formosanae 8 parts, 5 parts, catechu, Cacumen Platycladi 6 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, defoamer is appropriate.
The preparation method of the above-mentioned binder for wound anti-inflammation hemostasia is:
(1) get Semen Glycines, the amount of Semen Glycines be Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight 1/6, put into pot and make popular, add Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae stir together with Pseudobulbus Bletillae (Rhizoma Bletillae), be as the criterion so that bean is ripe, take out, sieve de-etiolation bean, is ground into fine powder;
(2) get Rhizoma Et Radix Notopterygii, Herba Taraxaci, Folium Callicarpae Formosanae and Cacumen Platycladi, removing impurity, adding 13 times amount volume fractions is the ethanol water of 55%, room temperature lixiviate 3 times, each 8 hours, merges three extracting solution, decompression recycling ethanol is also condensed into the thick paste that relative density is 1.28, dry, pulverize into coarse powder, cross 40 mesh sieves, add the vinegar of coarse powder weight 1/6, stir evenly, vexed 4 hours, dry, pulverize into fine powder;
(3) get catechu, be ground into coarse powder, be placed in 50 DEG C of vacuum drying ovens dry 12 hours, be ground into fine powder;
(4) step (1), step (2) and step (3) gained are mixed, (the present embodiment defoamer used is DX-03 silicone fluid defoamer to add base polyurethane prepolymer for use as (purchased from Shanghai He Cheng macromolecule Science and Technology Ltd.) and defoamer, purchased from Jinan multidimensional bridge Chemical Co., Ltd.), the consumption of defoamer is 0.2% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight, 30 DEG C of temperature, under nitrogen protection condition, stir 2.5 hours, obtain coating agent;
(5) step (4) gained coating agent is evenly coated in Ji Bushang, coating agent consumption is 38g on every square of mesityl cloth, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the binder for wound anti-inflammation hemostasia.
The using method that gained of the present invention is used for the binder of wound anti-inflammation hemostasia is: select to be applicable to size according to different positions, cotton-padded covering on injury cover, open packaging, take out binder, in normal-temperature water, soak 3-4 second and extrude 2 ~ 3 times, squeeze after taking out and remove excessive moisture, be wound around and need fixing position layer 2-3, often circle laminates 1/2-2/3 of binder width, carries out moulding after winding as required, make it to combine closely, smooth surface.
Embodiment 2 one kinds of binders for wound anti-inflammation hemostasia, the primary raw material getting following weight parts is prepared from (every part is 360g): base polyurethane prepolymer for use as 30 parts, Radix Notoginseng 7 parts, Rhizoma Typhonii 12 parts, Rhizoma Et Radix Notopterygii 8 parts, Herba Taraxaci 10 parts, Radix Berberidis Amurensis 13 parts, Radix Sanguisorbae 9 parts, Folium Callicarpae Formosanae 11 parts, 10 parts, catechu, Cacumen Platycladi 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 14 parts, defoamer is appropriate.
The preparation method of the above-mentioned binder for wound anti-inflammation hemostasia is:
(1) get Semen Glycines, the amount of Semen Glycines be Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight 1/2, put into pot and make popular, add Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae stir together with Pseudobulbus Bletillae (Rhizoma Bletillae), be as the criterion so that bean is ripe, take out, sieve de-etiolation bean, is ground into fine powder;
(2) get Rhizoma Et Radix Notopterygii, Herba Taraxaci, Folium Callicarpae Formosanae and Cacumen Platycladi, removing impurity, adding 13 times amount volume fractions is the ethanol water of 75%, room temperature lixiviate 3 times, each 8 hours, merges three extracting solution, decompression recycling ethanol is also condensed into the thick paste that relative density is 1.34, dry, pulverize into coarse powder, cross 40 mesh sieves, add the vinegar of coarse powder weight 1/2, stir evenly, vexed 6 hours, dry, pulverize into fine powder;
(3) get catechu, be ground into coarse powder, be placed in 50 DEG C of vacuum drying ovens dry 12 hours, be ground into fine powder;
(4) step (1), step (2) and step (3) gained are mixed, (the present embodiment defoamer used is DX-03 silicone fluid defoamer to add base polyurethane prepolymer for use as (purchased from Shanghai He Cheng macromolecule Science and Technology Ltd.) and defoamer, purchased from Jinan multidimensional bridge Chemical Co., Ltd.), the consumption of defoamer is 0.55% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight, 45 DEG C of temperature, under nitrogen protection condition, stir 4.5 hours, obtain coating agent;
(5) step (4) gained coating agent is evenly coated in Ji Bushang, coating agent consumption is 62g on every square of mesityl cloth, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the binder for wound anti-inflammation hemostasia.
Model case one: Wu XX, man, 45 years old.The left arm of patient is chopped wound by kitchen knife accidentally, bleeds more than, with pain.Use the present embodiment gained to be used for the binder of wound anti-inflammation hemostasia, blood stops very soon, and pain disappears.Do not occur the problems such as infection in use procedure, wound healing is good.
Embodiment 3 one kinds of binders for wound anti-inflammation hemostasia, the primary raw material getting following weight parts is prepared from (every part is 360g): base polyurethane prepolymer for use as 26 parts, Radix Notoginseng 5 parts, Rhizoma Typhonii 9 parts, Rhizoma Et Radix Notopterygii 5 parts, Herba Taraxaci 6 parts, Radix Berberidis Amurensis 11 parts, Radix Sanguisorbae 7 parts, Folium Callicarpae Formosanae 9 parts, 7 parts, catechu, Cacumen Platycladi 7 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 11 parts, defoamer is appropriate.
The preparation method of the above-mentioned binder for wound anti-inflammation hemostasia is:
(1) get Semen Glycines, the amount of Semen Glycines be Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight 1/5, put into pot and make popular, add Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae stir together with Pseudobulbus Bletillae (Rhizoma Bletillae), be as the criterion so that bean is ripe, take out, sieve de-etiolation bean, is ground into fine powder;
(2) get Rhizoma Et Radix Notopterygii, Herba Taraxaci, Folium Callicarpae Formosanae and Cacumen Platycladi, removing impurity, adding 13 times amount volume fractions is the ethanol water of 60%, room temperature lixiviate 3 times, each 8 hours, merges three extracting solution, decompression recycling ethanol is also condensed into the thick paste that relative density is 1.3, dry, pulverize into coarse powder, cross 40 mesh sieves, add the vinegar of coarse powder weight 1/5, stir evenly, vexed 4.5 hours, dry, pulverize into fine powder;
(3) get catechu, be ground into coarse powder, be placed in 50 DEG C of vacuum drying ovens dry 12 hours, be ground into fine powder;
(4) step (1), step (2) and step (3) gained are mixed, (the present embodiment defoamer used is DX-03 silicone fluid defoamer to add base polyurethane prepolymer for use as (purchased from Shandong Rayleigh new material company limited) and defoamer, purchased from Jinan multidimensional bridge Chemical Co., Ltd.), the consumption of defoamer is 0.25% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight, 32 DEG C of temperature, under nitrogen protection condition, stir 3 hours, obtain coating agent;
(5) step (4) gained coating agent is evenly coated in Ji Bushang, coating agent consumption is 43g on every square of mesityl cloth, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the binder for wound anti-inflammation hemostasia.
Model case two: Liu XX, female, 60 years old.Patient has knocked shank because of carelessness when walking, and leg wounds streamed blood is more than.Use the present embodiment gained to be used for the binder of wound anti-inflammation hemostasia, blood stops very soon.Do not occur the problems such as infection in use procedure, wound healing is good.
Embodiment 4 one kinds of binders for wound anti-inflammation hemostasia, the primary raw material getting following weight parts is prepared from (every part is 360g): base polyurethane prepolymer for use as 29 parts, Radix Notoginseng 6 parts, Rhizoma Typhonii 11 parts, Rhizoma Et Radix Notopterygii 7 parts, Herba Taraxaci 8 parts, Radix Berberidis Amurensis 12 parts, Radix Sanguisorbae 8 parts, Folium Callicarpae Formosanae 10 parts, 9 parts, catechu, Cacumen Platycladi 8 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 13 parts, defoamer is appropriate.
The preparation method of the above-mentioned binder for wound anti-inflammation hemostasia is:
(1) get Semen Glycines, the amount of Semen Glycines be Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight 1/3, put into pot and make popular, add Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae stir together with Pseudobulbus Bletillae (Rhizoma Bletillae), be as the criterion so that bean is ripe, take out, sieve de-etiolation bean, is ground into fine powder;
(2) get Rhizoma Et Radix Notopterygii, Herba Taraxaci, Folium Callicarpae Formosanae and Cacumen Platycladi, removing impurity, adding 13 times amount volume fractions is the ethanol water of 70%, room temperature lixiviate 3 times, each 8 hours, merges three extracting solution, decompression recycling ethanol is also condensed into the thick paste that relative density is 1.33, dry, pulverize into coarse powder, cross 40 mesh sieves, add the vinegar of coarse powder weight 1/3, stir evenly, vexed 5.5 hours, dry, pulverize into fine powder;
(3) get catechu, be ground into coarse powder, be placed in 50 DEG C of vacuum drying ovens dry 12 hours, be ground into fine powder;
(4) step (1), step (2) and step (3) gained are mixed, (the present embodiment defoamer used is DX-03 silicone fluid defoamer to add base polyurethane prepolymer for use as (purchased from Shandong Rayleigh new material company limited) and defoamer, purchased from Jinan multidimensional bridge Chemical Co., Ltd.), the consumption of defoamer is 0.4% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight, 40 DEG C of temperature, under nitrogen protection condition, stir 4 hours, obtain coating agent;
(5) step (4) gained coating agent is evenly coated in Ji Bushang, coating agent consumption is 54g on every square of mesityl cloth, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the binder for wound anti-inflammation hemostasia.
Model case three: neat XX, female, 34 years old.Patient hurts left index finger accidentally, and wounds streamed blood was more than at that time.Use the present embodiment gained to be used for the binder of wound anti-inflammation hemostasia, blood stops very soon.Do not occur the problems such as infection in use procedure, wound healing is good.
Embodiment 5 one kinds of binders for wound anti-inflammation hemostasia, the primary raw material getting following weight parts is prepared from (every part is 360g): base polyurethane prepolymer for use as 27 parts, Radix Notoginseng 5.5 parts, Rhizoma Typhonii 10 parts, Rhizoma Et Radix Notopterygii 6 parts, Herba Taraxaci 7 parts, Radix Berberidis Amurensis 11.5 parts, Radix Sanguisorbae 7.5 parts, Folium Callicarpae Formosanae 9.5 parts, 8 parts, catechu, Cacumen Platycladi 7.5 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts, defoamer is appropriate.
The preparation method of the above-mentioned binder for wound anti-inflammation hemostasia is:
(1) get Semen Glycines, the amount of Semen Glycines be Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight 1/4, put into pot and make popular, add Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae stir together with Pseudobulbus Bletillae (Rhizoma Bletillae), be as the criterion so that bean is ripe, take out, sieve de-etiolation bean, is ground into fine powder;
(2) get Rhizoma Et Radix Notopterygii, Herba Taraxaci, Folium Callicarpae Formosanae and Cacumen Platycladi, removing impurity, adding 13 times amount volume fractions is the ethanol water of 65%, room temperature lixiviate 3 times, each 8 hours, merges three extracting solution, decompression recycling ethanol is also condensed into the thick paste that relative density is 1.32, dry, pulverize into coarse powder, cross 40 mesh sieves, add the vinegar of coarse powder weight 1/4, stir evenly, vexed 5 hours, dry, pulverize into fine powder;
(3) get catechu, be ground into coarse powder, be placed in 50 DEG C of vacuum drying ovens dry 12 hours, be ground into fine powder;
(4) step (1), step (2) and step (3) gained are mixed, (the present embodiment defoamer used is DX-03 silicone fluid defoamer to add base polyurethane prepolymer for use as (purchased from Shandong Rayleigh new material company limited) and defoamer, purchased from Jinan multidimensional bridge Chemical Co., Ltd.), the consumption of defoamer is 0.35% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight, 35 DEG C of temperature, under nitrogen protection condition, stir 3.5 hours, obtain coating agent;
(5) step (4) gained coating agent is evenly coated in Ji Bushang, coating agent consumption is 48g on every square of mesityl cloth, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the binder for wound anti-inflammation hemostasia.
The effect of the present invention's primary raw material used is as follows:
Base polyurethane prepolymer for use as: polyurethane reacts formed high molecular polymer under certain condition by polyisocyanates and polyethers or PEPA.The performed polymer of polyurethane is briefly the reactable semi-finished product that polyisocyanates and polyhydric alcohol control certain proportion react and obtain.Due to polyisocyanates and polyhydric alcohol of a great variety, reaction ratio is different, therefore can be made into the performed polymer of all size.Base polyurethane prepolymer for use as answers land used to be applied to the numerous areas such as polyurethane adhesive, coating, elastomer, foam and fiber widely.
Radix Notoginseng: base is former: be the root of panax araliaceae plant.The property of medicine: sweet in the mouth, micro-hardship, warm in nature.Return liver, stomach, the heart, lung, large intestine channel.Function cures mainly: hemostasis, loose blood, analgesic therapy.Main traumatic injury congestive edema, thoracic obstruction angor, lump in the abdomen, blood stasis amenorrhea, dysmenorrhea, puerperal, stasis of blood the moon was suffered from abdominal pain, sore, carbuncle and painful swelling.
Rhizoma Typhonii: base is former: be the tuber of aroid Herba Typhonii gigantei.The property of medicine: acrid in the mouth, sweet, warm in nature, poisonous.Return stomach, Liver Channel.Function cures mainly: dispel the wind expectorant, the meridian dredging, removing toxic substances analgesia.In master, wind-phlegm is stopped up, facial hemiparalysis, migraine, tetanus, venom, scrofula tuberculosis, carbuncle.
Rhizoma Et Radix Notopterygii: base is former: be dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii.The property of medicine: pungent, bitter, temperature.Return bladder, kidney channel.Function cures mainly: cold expelling, dispels the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
Herba Taraxaci: base is former: for feverfew Herba Taraxaci, alkali ground Herba Taraxaci, Herba Taraxaci ohwiani, different luxuriant Herba Taraxaci, Taraxacum asiatica Dahlst, Taraxacum erythropodium Kifag etc. belong to the herb of various plants together.The property of medicine: bitter in the mouth, sweet, cold in nature.Return liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Main acute mastitis, lung abscess, acute appendicitis, mumps, furuncle carbuncle toxin, conjunctival congestion and swelling pain, cold, fever, cough, laryngopharynx swelling and pain, stomach-fire, enteritis, dysentery, hepatitis, cholecystitis, urinary tract infection, snake bite and insect sting.
Radix Berberidis Amurensis: another name: sub-bark of a cork tree, Catunaregam spinosa (Thunb.) Tirveng., Radix Berberidis, mountain Huang thorn.Nature and flavor: bitter, Great Cold.Gui Jing: return lung, liver, spleen channel.Effect: heat clearing and damp drying, eliminating fire and detoxication.Cure mainly: diarrhea due to damp-heat, dysentery, aphtha of the mouth and tongue, pharyngalgia sore throat, conjunctival congestion and swelling pain, carbuncle furuncle.
Radix Sanguisorbae: base is former: be the root and rhizome of Flos Rosae Multiflorae kind of plant Radix Sanguisorbae.Chemical analysis: root contains tannin about 17%, triterpenoid saponin 2.5 ~ 4.0%.Isolated Saponin has: ziyu glycoside I, produces pomolic acid, arabinose and glucose after hydrolysis, ziyu glycoside II, and produce pomolic acid and arabinose after hydrolysis, ground Fructus Kaki Saponin B, Preliminary Identification is the triterpenoid saponin of glucuronic acid.Stem and leaf contains the glycoside of Quercetin and nimbecetin, the triterpene substances such as ursolic acid.Leaf is containing vitamin C.Flower is containing Chrysanthemin, the two glycoside pressure effect of Centaurea cyanus.The property of medicine: picric acid, cold.Return liver, large intestine channel.Function cures mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing.Control haematemesis, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.
Folium Callicarpae Formosanae: another name cercis, Folium Callicarpae Formosanae are the leaf of dicotyledon medicine Verbenaceae callicarpa pedunculata, Callicarpa dichotoma, callicarpa cathayana Chang, Radix Callicarpae Giraldii.The property of medicine: bitter, puckery; Cool.Function cures mainly: astringing to arrest bleeding, heat-clearing and toxic substances removing.Main hematemesis, spitting of blood, epistaxis, has blood in stool, hematuria, gingival hemorrhage, metrorrhagia, skin purpura, traumatic hemorrhage, swollen ulcer drug, venom, burn.
Catechu: base is former: the dry branch for pulse family sallee catechu tree adds the dry extract that decocting juice concentrates.The property of medicine: bitter, puckery, is slightly cold.Function cures mainly: removing heat-phlegm, and sore is stopped blooding.For cough due to lung-heat, spitting of blood, diarrhoea, infantile dyspepsia; External is controlled skin infection and is not closed up for a long time, skin eczema, aphtha, tonsillitis.
Cacumen Platycladi: base is former: be branch top and the leaf of Cupressaceae plant Cacumen Platycladi.The property of medicine: bitter; Puckery; Cold nature.Return lung, liver, large intestine channel.Function cures mainly: cooling blood for hemostasis; Eliminating phlegm and stopping cough; Wind-damp dispelling; Loose toxic swelling.Cure mainly spitting of blood; Spit blood; Epistaxis; Hematuria; Dysentery; Discharging fresh blood stool; Metrorrhagia is more than; Cough with copious phlegm; Rheumatic arthralgia; Erysipelas; Mumps, scalds.
Pseudobulbus Bletillae (Rhizoma Bletillae): base is former: be the rhizome of orchid Pseudobulbus Bletillae (Rhizoma Bletillae).The property of medicine: bitter; Sweet; Puckery; Cold.Attach to the lung and stomach meridians.Function cures mainly: astringing to arrest bleeding, detumescence and promoting granulation.Main spitting of blood, spit blood, epistaxis, has blood in stool, traumatic hemorrhage, carbuncle pyogenic infections from tumour or sore, scalds and burns, rhagadia manus et pedis, anal fissure.
Defoamer: defoamer, also claims anti-foam agent.Defoamer mostly is liquid compound product, is mainly divided three classes: mineral oils, silicone based, polyethers.Mineral oil defoaming agent is made up of carrier, activating agent etc. usually.Carrier is the material of low surface tension, and its effect is carrying and dilution, and common carrier is water, fatty alcohol etc.; The effect of activating agent suppresses and eliminates foam, and conventional has wax, aliphatic amide, fat etc.Silicone based defoamer generally comprises polydimethylsiloxane etc.Silicone based defoamer dissolubility is poor, have at normal temperatures antifoaming speed very fast, press down bubble better, but at high temperature occur layering, antifoaming speed comparatively slow, press down the features such as bubble is poor.Polyethers defoamer comprises polyoxypropylene ethylene oxide glycerin ether etc.The features such as polyethers defoamer has but the bubble time is long, effective, antifoaming speed is fast, Heat stability is good.
Test example gets 30 healthy White Rabbits, is divided into experimental group and matched group at random, performs the operation after auricular vein gives pentobarbital sodium (30mg/mL) anesthesia by lmL/kg dosage.Under ensiform process of sternum, cut long 6cm otch along abdomen median line, be separated laggard abdomen a little; As appeared unclear, can upwards extend otch 2cm, cutting off ensiform process of sternum, avoid damaging cardiopulmonary; Expose and fix liver a little.Hepatectomize each 1 piece of left outside leaf, the long 3cm of right inside leaf texture, wide 2cm, the thick 0.8cm of edge of wound.Model wipes the blood of ejection after setting up, experimental group immediately in wound surface partial cover gained of the present invention be used for the binder of wound anti-inflammation hemostasia, with the pressurization of 100g counterweight, within every 30 seconds, remove counterweight and dip in clean filter paper and wipe 1 time, observation index with not hemorrhage for degree; Matched group is lid sterile gauze and pressurization only.Record the bleeding time of every White Rabbit.
Table 1: gained of the present invention is used for the binder haemostatic effect of wound anti-inflammation hemostasia
As can be seen from Table 1, comparing the bleeding time between experimental group and matched group has notable difference, and both result displays all can play anastalsis on the whole, and the overall haemostatic effect of experimental group is better than matched group.Test shows, the binder that gained of the present invention is used for wound anti-inflammation hemostasia significantly can shorten bleeding stopping period, and this illustrates that gained of the present invention has good haemostatic effect for the binder of wound anti-inflammation hemostasia.
The binder that gained of the present invention is used for wound anti-inflammation hemostasia is prepared from by primary raw materials such as base polyurethane prepolymer for use as, Radix Notoginseng, Rhizoma Typhonii and Rhizoma Et Radix Notopterygiis.Wherein, pseudo-ginseng hemostatic, loose blood, analgesic therapy.Rhizoma Typhonii dispels the wind expectorant, the meridian dredging, removing toxic substances analgesia.Rhizoma Et Radix Notopterygii cold expelling, dispels the wind, dehumidifying, pain relieving.Herba Taraxaci heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Radix Berberidis Amurensis heat clearing and damp drying, eliminating fire and detoxication.Radix Sanguisorbae cooling blood for hemostasis, heat-clearing and toxic substances removing.Folium Callicarpae Formosanae astringing to arrest bleeding, heat-clearing and toxic substances removing.Catechu removing heat-phlegm, sore is stopped blooding.Cacumen Platycladi cooling blood for hemostasis; Eliminating phlegm and stopping cough; Wind-damp dispelling; Loose toxic swelling.Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation.Products obtained therefrom of the present invention has no side effect, good permeability, and hygroscopicity is strong, and to human body without pessimal stimulation, there is good bio-compatibility, there is the effects such as hemostasis, sterilization, antiinflammatory, pain relieving, detumescence and promoting granulation, hemostasis rapidly, not only can alleviate the misery of patient, prevent muscle contraction, can also wound infection be prevented, healing acceleration, improve swelling, be convenient to injury skeleton motion, be conducive to the recovery of function, patient uses comfortable, easy to use.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. for a binder for wound anti-inflammation hemostasia, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: base polyurethane prepolymer for use as 24-30, Radix Notoginseng 4-7, Rhizoma Typhonii 8-12, Rhizoma Et Radix Notopterygii 4-8, Herba Taraxaci 5-10, Radix Berberidis Amurensis 10-13, Radix Sanguisorbae 6-9, Folium Callicarpae Formosanae 8-11, catechu 5-10, Cacumen Platycladi 6-9, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-14, defoamer is appropriate.
2., as claimed in claim 1 for the binder of wound anti-inflammation hemostasia, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: base polyurethane prepolymer for use as 26-29, Radix Notoginseng 5-6, Rhizoma Typhonii 9-11, Rhizoma Et Radix Notopterygii 5-7, Herba Taraxaci 6-8, Radix Berberidis Amurensis 11-12, Radix Sanguisorbae 7-8, Folium Callicarpae Formosanae 9-10, catechu 7-9, Cacumen Platycladi 7-8, Pseudobulbus Bletillae (Rhizoma Bletillae) 11-13, defoamer is appropriate.
3., as claimed in claim 1 for the binder of wound anti-inflammation hemostasia, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: base polyurethane prepolymer for use as 27, Radix Notoginseng 5.5, Rhizoma Typhonii 10, Rhizoma Et Radix Notopterygii 6, Herba Taraxaci 7, Radix Berberidis Amurensis 11.5, Radix Sanguisorbae 7.5, Folium Callicarpae Formosanae 9.5, catechu 8, Cacumen Platycladi 7.5, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, defoamer is appropriate.
4. the preparation method of the binder for wound anti-inflammation hemostasia as described in as arbitrary in claims 1 to 3, it is characterized in that, step is as follows:
(1) get Semen Glycines, the amount of Semen Glycines is the 1/6-1/2 of Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight, puts into pot and makes popular, add Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae stir together with Pseudobulbus Bletillae (Rhizoma Bletillae), be as the criterion so that bean is ripe, take out, sieve de-etiolation bean, is ground into fine powder;
(2) get Rhizoma Et Radix Notopterygii, Herba Taraxaci, Folium Callicarpae Formosanae and Cacumen Platycladi, removing impurity, (preferred, adding 13 times amount volume fractions is the ethanol water of 60%-70% to add the ethanol water that 13 times amount volume fractions are 55%-75%; Be more preferably, adding 13 times amount volume fractions is the ethanol water of 65%), room temperature lixiviate 3 times, each 8 hours, merge three extracting solution, decompression recycling ethanol is also condensed into the thick paste that relative density is 1.28-1.34, dry, be ground into coarse powder, cross 40 mesh sieves, add the vinegar of coarse powder weight 1/6-1/2, stir evenly, vexed 4-6 hour, dry, pulverize into fine powder;
(3) get catechu, be ground into coarse powder, be placed in 50 DEG C of vacuum drying ovens dry 12 hours, be ground into fine powder;
(4) step (1), step (2) and step (3) gained are mixed, add base polyurethane prepolymer for use as and defoamer, the consumption of defoamer is the 0.2%-0.55% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight, 30-45 DEG C of temperature (preferably, 32-40 DEG C of temperature; Be more preferably, 35 DEG C of temperature), under nitrogen protection condition, stir and (preferably, stir 3-4 hour in 2.5-4.5 hour; Be more preferably, stir 3.5 hours), obtain coating agent;
(5) step (4) gained coating agent is evenly coated in Ji Bushang, coating agent consumption is that on every square of mesityl cloth, 38-62g(is preferred, and coating agent consumption is 43-54g on every square of mesityl cloth; Be more preferably, coating agent consumption is 48g on every square of mesityl cloth), through work feed, roll-in, rolling, shearing, sealing, packed, obtain the binder for wound anti-inflammation hemostasia.
5. as claimed in claim 4 for the preparation method of the binder of wound anti-inflammation hemostasia, it is characterized in that, in step (1) amount of Semen Glycines be Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight the amount of the preferred Semen Glycines of 1/5-1/3(be Radix Notoginseng, Rhizoma Typhonii, Radix Berberidis Amurensis, Radix Sanguisorbae and Pseudobulbus Bletillae (Rhizoma Bletillae) gross weight 1/4).
6. as claimed in claim 4 for the preparation method of the binder of wound anti-inflammation hemostasia, it is characterized in that, decompression recycling ethanol in step (2) is also condensed into the thick paste (preferred decompression recycling ethanol is also condensed into the thick paste that relative density is 1.32) that relative density is 1.3-1.33.
7., as claimed in claim 4 for the preparation method of the binder of wound anti-inflammation hemostasia, it is characterized in that, in step (2), add the vinegar (preferably adding the vinegar of coarse powder weight 1/4) of coarse powder weight 1/5-1/3.
8., as claimed in claim 4 for the preparation method of the binder of wound anti-inflammation hemostasia, it is characterized in that, in step (2) vexed 4.5-5.5 hour (preferably vexed 5 hours).
9. as claimed in claim 4 for the preparation method of the binder of wound anti-inflammation hemostasia, it is characterized in that, base polyurethane prepolymer for use as described in step (4) is purchased from Shanghai He Cheng macromolecule Science and Technology Ltd. or Shandong Rayleigh new material company limited (preferred described base polyurethane prepolymer for use as is purchased from Shandong Rayleigh new material company limited).
10. as claimed in claim 4 for the preparation method of the binder of wound anti-inflammation hemostasia, it is characterized in that, the consumption of defoamer is step (1) in step (4), the consumption of the preferred defoamer of 0.25%-0.4%(of step (2), step (3) gained and base polyurethane prepolymer for use as gross weight is 0.35% of step (1), step (2), step (3) gained and base polyurethane prepolymer for use as gross weight).
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| CN108283726A (en) * | 2018-03-05 | 2018-07-17 | 湖南科技大学 | A kind of preparation method of polyurethane wound dressing |
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