CN108283726A - A kind of preparation method of polyurethane wound dressing - Google Patents
A kind of preparation method of polyurethane wound dressing Download PDFInfo
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- CN108283726A CN108283726A CN201810179826.7A CN201810179826A CN108283726A CN 108283726 A CN108283726 A CN 108283726A CN 201810179826 A CN201810179826 A CN 201810179826A CN 108283726 A CN108283726 A CN 108283726A
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- polyurethane
- wound dressing
- particle
- film
- release paper
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Abstract
The invention discloses a kind of preparation methods of polyurethane wound dressing.The present invention is mainly that polyurethane hydrogel particle, thermoplastic polyurethane particle, solvent are added in reactor, and heating stirring makes polyurethane hydrogel particle and thermoplastic polyurethane particle be completely dissolved in solvent, and polyurethane solutions are obtained after cooling；In polyurethane solution, Notoginseng Root is added, high-speed stirred obtains solidliquid mixture and vacuum defoaming；By solidliquid mixture even application in release paper, release paper is immersed in deionized water；Wait for that solidliquid mixture is fully cured film forming and is placed on drying in drying box；Release paper is removed after cooling to get to immobilized Radix Notoginseng film；Immobilized Radix Notoginseng film is soaked in 3h in field thistle extracting solution, then carries out vacuum freeze drying, dual drug-loading film is made；Medicine carrying membrane is cut into appropriate size according to practical application request, and is pasted on medical non-woven fabrics gauze to get product.Raw material of the present invention is easy to get, equipment is simple, product energy hemostasia and dissipation blood stasis, detumescence ding-tong.
Description
Technical field
The invention belongs to organic composite material technical fields, and in particular to a kind of preparation side of polyurethane wound dressing
Method.
Background technology
Wound dressing is generally covered on the surface of a wound, forms protective effect to the surface of a wound, wound healing is widely used in
Wound healing, such as scratch, scuffing and scald.Traditional wound dressing is with medical absorbent cotton gauze, cotton pad and petrolatum gauze etc.
Based on raw material.Traditional wound dressing is cheap, and simple production process, raw material sources are extensive, based on netted braiding structure, but
Absorbability is relatively low, cannot prevent wound surface sepage persistent accumulation.With deepening continuously for wound dressing research, traditional dressing
Distinct disadvantage gradually is shown, if haemostatic effect is poor, dressing shield effectiveness is poor, is also easy to produce exogenous infection, easily to wound when replacement
Face generates secondary injury, cannot keep surface of a wound moistening etc..To solve the above-mentioned problems, people also use physics and chemical method
Dressing is improved, drug is such as added in medical absorbent cotton, is added antibiotic composition etc. in hospital gauze, but all without
Method reaches well-content effect.
Invention content
The purpose of the present invention is to provide a kind of raw materials to be easy to get, the preparation side of the simple polyurethane wound dressing of equipment
Method.
The method of the present invention includes following steps in sequence：
(1) by dry polyurethane hydrogel particle, thermoplastic polyurethane particle, solvent according to 5~12:20~30:110
Weight ratio be added reactor in, be heated to 50~80 DEG C and stir make polyurethane hydrogel particle and thermoplastic polyurethane particle
It is completely dissolved in solvent, after being cooled to room temperature, polyurethane solutions is made；
(2) in polyurethane solutions obtained by step (1), dry Notoginseng Root, polyurethane solutions and Notoginseng Root is added
Weight ratio be 135~152:25~50, and it is uniformly mixing to obtain solidliquid mixture, and vacuum defoaming using high speed agitator
0.5h；
(3) then release paper is immersed into deionized water by solidliquid mixture even application obtained by step (2) in release paper
In；Wait for that solidliquid mixture is fully cured film forming and is placed in 50 DEG C of drying boxes, dry 1~2h；Release paper is removed after cooling, i.e.,
Obtain immobilized Radix Notoginseng film；
(4) the immobilized Radix Notoginseng film obtained by step (3) is soaked in 3h in field thistle extracting solution, then carries out vacuum refrigeration and does
It is dry, dual drug-loading film is made；
(5) medicine carrying membrane is cut into appropriate size further according to practical application request, and is pasted on medical non-woven fabrics gauze,
Obtain a kind of polyurethane wound dressing.
Preferably, step (1) the polyurethane hydrogel particle is anionic polyurethane hydrogel particle.
Preferably, step (1) the thermoplastic polyurethane particle is polyether polyurethane particle, shore hardness 60A
Or 70A.
Preferably, step (1) described solvent is one kind in n,N-Dimethylformamide and n,N-dimethylacetamide.
Preferably, step (2) described Notoginseng Root is the brown ceramic powder that fineness is 500~2000 mesh.
Preferably, in solidliquid mixture obtained in step (2), polyurethane hydrogel, thermoplastic polyurethane, solvent,
The weight percent of Radix Notoginseng powder is：Polyurethane hydrogel accounts for 3.1%~5.9%, and thermoplastic polyurethane accounts for 12.5%~14.9%,
Solvent accounts for 54.5%~68.8%, and Radix Notoginseng powder accounts for 15.7%~24.7%.
Preferably, the weight percent of field thistle extracting solution is in step (4)：Herba Cirsii extract ingredient accounts for 5.0%~
10.0%, deionized water accounts for 90.0%~95.0%.
Preferably, dual drug-loading film outward appearance obtained by step (5) is brown, by being coated on release paper in regulating step (3)
On solidliquid mixture thickness control dual drug-loading film thickness between 0.47~0.60mm.
The present invention uses polyurethane hydrogel, thermoplastic polyurethane material and Radix Notoginseng powder as primary raw material first, and leads to
It crosses suitable ratio and film-forming method appropriate produces a kind of polyurethane wound dressing.This method and traditional dressing production technology
It compares, has the following advantages：Polyurethane wound dressing, Radix Notoginseng powder content in product of the present invention is high, therefore the wound is applied
Expect, with the stopping blooding, is promoting blood circulation and removing blood stasis of Radix Notoginseng powder, detumescence ding-tong and other effects, can very effectively be used for burn and scald scar, operation scar
Trace, keloid patients, wound healing effectively avoid the surface of a wound from staying scar；Dual drug-loading film has also adsorbed in field thistle extracting solution
A large amount of active constituent, so the wound dressing also cooling blood and hemostasis with field thistle, eliminating stasis to resolve swelling and other effects.
Specific implementation mode
Below by specific embodiment, the present invention is described in further detail, wherein the raw material is medical
Grade product, equipment are the production equipment of general industry.
Embodiment 1：
Weigh 5 kilograms of anionic polyurethane hydrogel particles, the thermoplastic polyurethane that 20 kilograms of shore hardnesses are 60A
Grain, 110 kilograms of n,N-Dimethylformamide are placed in reactor, be heated to 50 DEG C and stir make polyurethane hydrogel particle and
Thermoplastic polyurethane particle is completely dissolved, and obtains polyurethane solutions after cooling；25 kilograms of 500 mesh Notoginseng Roots are added,
It is uniformly mixing to obtain solidliquid mixture with high speed agitator；After vacuum defoaming 0.5h, by solidliquid mixture with certain thickness
Coated in release paper, then release paper is immersed in deionized water, when film-forming is placed in drying box, in 50 DEG C of dryings
1h removes release paper after cooling, obtains immobilized Radix Notoginseng film；Immobilized Radix Notoginseng film is immersed field thistle extracting solution, and (Herba Cirsii extract contains
Amount impregnates 3h to be 5.0%) middle, handles to obtain dual drug-loading film through vacuum freeze drying；By adjusting coated on solid in release paper
Liquid mixture thickness is 0.47mm come the overall thickness for controlling dual drug-loading film；Dual drug-loading film is cut according to practical application request
At appropriate size, finally by dual drug-loading film paste on medical non-woven fabrics gauze to get to polyurethane wound dressing.
In the present embodiment, the weight percentage of anionic polyurethane hydrogel is 3.1% in gained solidliquid mixture,
The weight percentage of thermoplastic polyurethane is 12.5%, and the weight percentage of n,N-Dimethylformamide is 68.8%, three
The weight percentage of seven powder is 15.6%.Obtained dual drug-loading film color is brown, thickness 0.47mm.
Embodiment 2：
Weigh 7 kilograms of anionic polyurethane hydrogel particles, the thermoplastic polyurethane that 23 kilograms of shore hardnesses are 60A
Grain, 110 kilograms of n,N-dimethylacetamide are placed in reactor, be heated to 60 DEG C and stir make polyurethane hydrogel particle and
Thermoplastic polyurethane particle is completely dissolved, and obtains polyurethane solutions after cooling；30 kilograms of 1000 mesh Notoginseng Roots are added,
It is uniformly mixing to obtain solidliquid mixture with high speed agitator；After vacuum defoaming 0.5h, by solidliquid mixture with certain thickness
Coated in release paper, then release paper is immersed in deionized water, when film-forming is placed in drying box, in 50 DEG C of dryings
2h removes release paper after cooling, obtains immobilized Radix Notoginseng film；Immobilized Radix Notoginseng film is immersed field thistle extracting solution, and (Herba Cirsii extract contains
Amount impregnates 3h to be 7.0%) middle, handles to obtain dual drug-loading film through vacuum freeze drying；By adjusting coated in release paper
Solidliquid mixture thickness is 0.52mm come the overall thickness for controlling dual drug-loading film；Dual drug-loading film is cut out according to practical application request
Be cut into appropriate size, finally by dual drug-loading film paste on medical non-woven fabrics gauze to get to polyurethane wound dressing.
In the present embodiment, the weight percentage of anionic polyurethane hydrogel is 4.1% in gained solidliquid mixture,
The weight percentage of thermoplastic polyurethane is 13.5%, and the weight percentage of n,N-dimethylacetamide is 64.7%, three
The weight percentage of seven powder is 17.7%.Obtained dual drug-loading film color is brown, thickness 0.52mm.
Embodiment 3：
Weigh 10 kilograms of anionic polyurethane hydrogel particles, the thermoplastic polyurethane that 27 kilograms of shore hardnesses are 70A
Particle, 110 kilograms of n,N-Dimethylformamide are placed in reactor, are heated to 70 DEG C and stir to make polyurethane hydrogel particle
It is completely dissolved with thermoplastic polyurethane particle, obtains polyurethane solutions after cooling；Add 40 kilograms of 1500 mesh Radix Notoginseng powders
End is uniformly mixing to obtain solidliquid mixture with high speed agitator；After vacuum defoaming 0.5h, by solidliquid mixture with certain thickness
Then degree immerses release paper in deionized water coated in release paper, dry in 50 DEG C when film-forming is placed in drying box
Dry 1h, removes release paper after cooling, obtains immobilized Radix Notoginseng film；Immobilized Radix Notoginseng film is immersed into field thistle extracting solution (Herba Cirsii extract
Content be 9.0%) in impregnate 3h, handle to obtain dual drug-loading film through vacuum freeze drying；By adjusting coated in release paper
Solidliquid mixture thickness come control dual drug-loading film overall thickness be 0.57mm；According to practical application request by dual drug-loading film
Be cut into appropriate size, finally by dual drug-loading film paste on medical non-woven fabrics gauze to get to polyurethane wound dressing.
In the present embodiment, the weight percentage of anionic polyurethane hydrogel is 5.3% in gained solidliquid mixture,
The weight percentage of thermoplastic polyurethane is 14.4%, and the weight percentage of n,N-Dimethylformamide is 58.8%, three
The weight percentage of seven powder is 21.5%.Obtained dual drug-loading film color is brown, thickness 0.57mm.
Embodiment 4：
Weigh 12 kilograms of anionic polyurethane hydrogel particles, the thermoplastic polyurethane that 30 kilograms of shore hardnesses are 70A
Particle, 110 kilograms of n,N-Dimethylformamide are placed in reactor, are heated to 80 DEG C and stir to make polyurethane hydrogel particle
It is completely dissolved with thermoplastic polyurethane particle, obtains polyurethane solutions after cooling；Add 50 kilograms of 2000 mesh Radix Notoginseng powders
End is uniformly mixing to obtain solidliquid mixture with high speed agitator；After vacuum defoaming 0.5h, by solidliquid mixture with certain thickness
Then degree immerses release paper in deionized water coated in release paper, dry in 50 DEG C when film-forming is placed in drying box
Dry 2h, removes release paper after cooling, obtains immobilized Radix Notoginseng film；Immobilized Radix Notoginseng film is immersed into field thistle extracting solution (Herba Cirsii extract
Content be 10.0%) in impregnate 3h, handle to obtain dual drug-loading film through vacuum freeze drying；By adjusting coated in release paper
Solidliquid mixture thickness come control dual drug-loading film overall thickness be 0.60mm；According to practical application request by dual drug-loading film
Be cut into appropriate size, finally by dual drug-loading film paste on medical non-woven fabrics gauze to get to polyurethane wound dressing.
In the present embodiment, the weight percentage of anionic polyurethane hydrogel is 5.9% in gained solidliquid mixture,
The weight percentage of thermoplastic polyurethane is 14.9%, and the weight percentage of n,N-Dimethylformamide is 54.5%, three
The weight percentage of seven powder is 24.7%.Obtained dual drug-loading film color is brown, thickness 0.60mm.
Claims (8)
1. a kind of preparation method of polyurethane wound dressing, it is characterised in that including following steps in sequence：
(1) by dry polyurethane hydrogel particle, thermoplastic polyurethane particle, solvent according to 5~12:20~30:110 weight
Amount is heated to 50~80 DEG C and stirring keeps polyurethane hydrogel particle and thermoplastic polyurethane particle abundant than being added in reactor
It is dissolved in solvent, after being cooled to room temperature, polyurethane solutions is made；
(2) in polyurethane solutions obtained by step (1), dry Notoginseng Root, the weight of polyurethane solutions and Notoginseng Root is added
Amount is than being 135~152:25~50, and it is uniformly mixing to obtain solidliquid mixture, and vacuum defoaming 0.5h using high speed agitator；
(3) then solidliquid mixture even application obtained by step (2) is immersed release paper in deionized water in release paper；
Wait for that solidliquid mixture is fully cured film forming and is placed in 50 DEG C of drying boxes, dry 1~2h；After cooling removal release paper to get
To immobilized Radix Notoginseng film；
(4) the immobilized Radix Notoginseng film obtained by step (3) is soaked in 3h in field thistle extracting solution, then carries out vacuum freeze drying, made
Obtain dual drug-loading film；
(5) medicine carrying membrane is cut into appropriate size further according to practical application request, and be pasted on medical non-woven fabrics gauze to get
To a kind of polyurethane wound dressing.
2. the preparation method of polyurethane wound dressing according to claim 1, it is characterised in that：Step (1) the poly- ammonia
Ester hydrogel particle is anionic polyurethane hydrogel particle.
3. the preparation method of polyurethane wound dressing according to claim 1, it is characterised in that：Step (1) described thermoplastic
Type polyurethane particle is polyether polyurethane particle, and shore hardness is 60A or 70A.
4. the preparation method of polyurethane wound dressing according to claim 1, it is characterised in that：Step (1) described solvent
For one kind in N,N-dimethylformamide and DMAC N,N' dimethyl acetamide.
5. the preparation method of polyurethane wound dressing according to claim 1, it is characterised in that：Step (2) described Radix Notoginseng
Powder is the brown ceramic powder that fineness is 500~2000 mesh.
6. the preparation method of polyurethane wound dressing according to claim 1, it is characterised in that：It is obtained in step (2)
Solidliquid mixture in, polyurethane hydrogel, thermoplastic polyurethane, solvent, Radix Notoginseng powder weight percent be：Polyurethane water-setting
Glue accounts for 3.1%~5.9%, and thermoplastic polyurethane accounts for 12.5%~14.9%, and solvent accounts for 54.5%~68.8%, and Radix Notoginseng powder accounts for
15.7%~24.7%.
7. the preparation method of polyurethane wound dressing according to claim 1, it is characterised in that：Field thistle carries in step (4)
Taking the weight percent of liquid is：Herba Cirsii extract ingredient accounts for 5.0%~10.0%, and deionized water accounts for 90.0%~95.0%.
8. the preparation method of polyurethane wound dressing according to claim 1, it is characterised in that：It is dual obtained by step (5)
Medicine carrying membrane appearance is brown, passes through the solidliquid mixture thickness control dual drug-loading being coated in regulating step (3) in release paper
Film thickness is between 0.47~0.60mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810179826.7A CN108283726A (en) | 2018-03-05 | 2018-03-05 | A kind of preparation method of polyurethane wound dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810179826.7A CN108283726A (en) | 2018-03-05 | 2018-03-05 | A kind of preparation method of polyurethane wound dressing |
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| CN108283726A true CN108283726A (en) | 2018-07-17 |
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ID=62833426
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| CN201810179826.7A Pending CN108283726A (en) | 2018-03-05 | 2018-03-05 | A kind of preparation method of polyurethane wound dressing |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112546283A (en) * | 2020-12-14 | 2021-03-26 | 安徽芨智生物科技有限公司 | Polyurethane-based wound dressing containing bletilla polysaccharide and preparation method thereof |
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Application publication date: 20180717 |