CN109289008A - A kind of traditional Chinese medicine plaster and preparation method thereof for treating osteoproliferation - Google Patents
A kind of traditional Chinese medicine plaster and preparation method thereof for treating osteoproliferation Download PDFInfo
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- CN109289008A CN109289008A CN201811260281.9A CN201811260281A CN109289008A CN 109289008 A CN109289008 A CN 109289008A CN 201811260281 A CN201811260281 A CN 201811260281A CN 109289008 A CN109289008 A CN 109289008A
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- chinese medicine
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- traditional chinese
- plaster
- osteoproliferation
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- 239000003814 drug Substances 0.000 title claims abstract description 85
- 239000011505 plaster Substances 0.000 title claims abstract description 63
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 52
- 239000011324 bead Substances 0.000 claims abstract description 40
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 40
- 239000004626 polylactic acid Substances 0.000 claims abstract description 40
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 26
- 239000004411 aluminium Substances 0.000 claims abstract description 20
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 20
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000004744 fabric Substances 0.000 claims abstract description 17
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003883 ointment base Substances 0.000 claims abstract description 11
- 239000006260 foam Substances 0.000 claims abstract description 8
- 239000002253 acid Substances 0.000 claims abstract description 7
- 229920002635 polyurethane Polymers 0.000 claims abstract description 7
- 239000004814 polyurethane Substances 0.000 claims abstract description 7
- 239000004005 microsphere Substances 0.000 claims abstract description 6
- 239000000919 ceramic Substances 0.000 claims description 21
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- 239000007788 liquid Substances 0.000 claims description 18
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- 244000163122 Curcuma domestica Species 0.000 claims description 12
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- 238000000034 method Methods 0.000 claims description 12
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 10
- 239000002674 ointment Substances 0.000 claims description 10
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- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 3
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims description 3
- NOIWSPXMNWKZPJ-UHFFFAOYSA-N 2-bromo-1-butyl-3-methyl-2h-imidazole Chemical class CCCCN1C=CN(C)C1Br NOIWSPXMNWKZPJ-UHFFFAOYSA-N 0.000 claims description 3
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 claims description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 3
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- 239000006071 cream Substances 0.000 claims description 3
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- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims description 3
- 229940114124 ferulic acid Drugs 0.000 claims description 3
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims description 3
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- 239000000314 lubricant Substances 0.000 claims description 3
- 239000003961 penetration enhancing agent Substances 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
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- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims description 3
- FQJXITFHANYMET-UHFFFAOYSA-N 3-pentoxypropane-1,2-diol Chemical compound CCCCCOCC(O)CO FQJXITFHANYMET-UHFFFAOYSA-N 0.000 claims description 2
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- XKBGEWXEAPTVCK-UHFFFAOYSA-M methyltrioctylammonium chloride Chemical compound [Cl-].CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC XKBGEWXEAPTVCK-UHFFFAOYSA-M 0.000 claims description 2
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- 239000001257 hydrogen Substances 0.000 description 4
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
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- 238000010438 heat treatment Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000009738 saturating Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
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- OARRHUQTFTUEOS-UHFFFAOYSA-N safranin Chemical compound [Cl-].C=12C=C(N)C(C)=CC2=NC2=CC(C)=C(N)C=C2[N+]=1C1=CC=CC=C1 OARRHUQTFTUEOS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Physical Education & Sports Medicine (AREA)
- Inorganic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Husbandry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to plaster technical fields, disclose a kind of traditional Chinese medicine plaster and preparation method thereof for treating osteoproliferation.The traditional Chinese medicine plaster includes Chinese medicine, polydactyl acid nonwoven fabric base plaster base fabric and the ointment bases comprising the massage bead that partial size is 0.5 ~ 1mm.The massage bead, which is negative, is loaded with the polylactic acid microsphere for the foam aluminium powder that partial size is 600 ~ 800nm.The polydactyl acid non-woven fabrics is the polylactic acid non-woven fabrics by FP and ATBC toughening modifying, and its outside has polyurethane water-proof layer.The traditional Chinese medicine plaster biocompatibility for the treatment of osteoproliferation of the invention, good permeability, antibacterial waterproof, drug effect is fast, lasting medicine is good, and preparation process is simple.
Description
Technical field
The present invention relates to plaster technical field more particularly to a kind of traditional Chinese medicine plaster for treating osteoproliferation and its systems
Preparation Method.
Background technique
Osteoproliferation is to endanger a kind of common disease of the elderly.Though currently, there is the drugs of many treatment osteoproliferations,
But the period for the treatment of is long, and effect is poor, and can not eradicate.Plaster is avoided that endo-medicine bring toxic side effect, and drug effect is high, takes effect
Obviously.But the phenomenon that allergy or even exanthemv easily occur for patient's long-time adhesive plaster with osteoproliferation.Existing cream
There are problems used below for medicine: one, plaster absorption efficiency is low, medication cycle is long；Two, plaster thickness is thin, bad adhesion；Three, cream
Medicine poor air permeability.
The patent of Chinese patent application Publication No. CN106390038A discloses a kind of for treating the outer of osteoproliferation
Adhesive plaster.The externally applied patch includes that the flower bud of lily magnolia, Radix Angelicae Pubescentis, rhizoma atractylodis, turmeric, soil such as are sprained at the components, is first put into each bulk pharmaceutical chemicals weighed up
It is dried in dryer, is broken into fine powder, crossed 120 meshes, obtain osteoproliferation powdery powder；Then powder is prepared into ointment shape,
Up to the externally applied plaster for the treatment of osteoproliferation.The externally applied patch is low in cost, and effect is preferable.However, the nursing of the externally applied patch
Bag uses airtight fiber cloth, so that the poor air permeability of externally applied patch, patient is easy to fester using skin for a long time, and drug is inhaled
Rate of producing effects is lower.
Summary of the invention
In order to solve the above-mentioned technical problems, the present invention provides a kind of traditional Chinese medicine plaster for treating osteoproliferation and its preparations
Method.The traditional Chinese medicine plaster biocompatibility for the treatment of osteoproliferation of the invention, good permeability, antibacterial waterproof, drug effect is fast, drug effect
Persistence is good, and preparation process is simple.
The specific technical proposal of the invention is: a kind of traditional Chinese medicine plaster for treating osteoproliferation, the traditional Chinese medicine plaster packet
Include Chinese medicine, polydactyl acid nonwoven fabric base plaster base fabric and the ointment bases comprising massage bead.
In the prior art, traditional Chinese medicine plaster surface layer is mostly made of acrylic resin or cotton.Although polyacrylic resin is malicious
The small, biocompatibility of property is also preferable, but after long-time use, will also result in patient skin redness itch.The good permeability of cotton,
But cotton is non-watertight, and the gap between cotton channels and collaterals is big, there is a problem of that ointment exudation, smell are pungent.
The plaster base fabric of the traditional Chinese medicine plaster for the treatment of osteoproliferation of the invention is by polylactic acid non-woven fabrics, polylactic acid non-woven fabrics
Good permeability, good biocompatibility directly will not generate adverse reaction with skin contact, in addition, polylactic acid has natural resist
Mite bacteriostasis, pH and skin are close, can release free small molecule in use, which has extremely strong wear
Saturating power, in conjunction with the lactic acid of this province of skin after can not only be effective antibacterial, additionally it is possible to improve the Chinese medicine of the treatment osteoproliferation
The absorption efficiency of effective component in emplastrum.The porous structure of polylactic acid non-woven fabrics can allow air and water vapo r transmission, gas permeability
Good, usage comfort is high.However, the intensity difference of polylactic acid non-woven fabrics, easy bursting, the present invention have carried out toughening modifying to it.Together
When, due to the ventilative of polylactic acid non-woven fabrics, good water permeability, cause its waterproofness very poor.In order to solve polylactic acid non-woven fabrics waterproof
Property difference disadvantage, the present invention is provided with layer of polyurethane on the outside of polylactic acid non-woven fabrics.The waterproof performance of polyurethane film is excellent,
Good permeability simultaneously.The plaster base fabric that polylactic acid non-woven fabrics and layer of polyurethane collectively constitute, not only breathe freely, waterproof performance it is good, together
When can promote the absorption of effective component in the traditional Chinese medicine plaster of the treatment osteoproliferation.
It include massage bead in ointment bases of the invention, when using the traditional Chinese medicine plaster of the treatment osteoproliferation, this is pressed
Rub pearl can self-heating, also, slightly turning joint, the massage bead will be subjected to displacement, and play the role of massage.Either
The self-heating of massage bead or its massage effect, can improve cell activity, promote blood circulation, and then promote treatment bone
The absorption of effective component in the traditional Chinese medicine plaster of matter hyperplasia.
Preferably, the partial size of the massage bead is 0.5~1mm.
When the partial size of massage bead is 0.5~1mm, massage effect is better.Massage bead partial size is excessive, and user is slightly movable
Joint will generate sense of discomfort；Massage bead partial size is too small to be will be unable to reach massage effect.
Preferably, the massage bead, which is negative, is loaded with the polylactic acid microsphere of aluminium powder.
Aluminium powder is reacted with water generates hydrogen, while releasing heat.Due to the presence of microballoon, which slowly occurs, energy
Enough persistently release hydrogen and heat.Hydrogen enters after skin the activity that can be improved cell, and low-grade fever can also improve cell activity, promotees
Into blood circulation, and then promote to treat the absorption of effective component in the traditional Chinese medicine plaster of osteoproliferation.Simultaneously as polylactic acid is saturating
Water, good permeability, so, moisture can smoothly enter polylactic acid microsphere and react with aluminium powder, and the hydrogen of generation also can be suitable
Benefit overflows polylactic acid microsphere and reaches skin.
Preferably, the aluminium powder is the foam aluminium powder that partial size is 600~800nm.
It is the foam aluminium powder of 600~800nm that aluminium powder used in the present invention, which selects partial size, and foam aluminium powder contact area is big, with water
The rate that the common aluminium powder of the speed ratio of reaction is reacted with water is fast, can give off heat in a short time, can be in the shortest time
Drug is sent to lesion, alleviates the pain of patient.
Preferably, the Chinese medicine includes the composition of following parts by weight: 8~10 parts of Radix Angelicae Sinensis, 7~9 parts of radix paeoniae rubra, Rhizoma Chuanxiong 6
~8 parts, 7~9 parts of safflower, 7~9 parts of Caulis Spatholobi, 7~9 parts of Radix Angelicae Pubescentis, 8~10 parts of turmeric, 13~15 parts of Eupolyphoge sinensis, Rhizoma Et Radix Notopterygii 11~
13 parts, 8~10 parts of rhizoma atractylodis, 10~12 parts of the root of Dahurain angelica, wide 180~220 parts and 400~460 parts of vegetable oil of pellet.
Radix Angelicae Pubescentis, turmeric, Eupolyphoge sinensis, Rhizoma Et Radix Notopterygii and rhizoma atractylodis in Chinese medicine of the invention all have the effect of excellent wind-expelling pain-stopping.
Especially Eupolyphoge sinensis and Rhizoma Et Radix Notopterygii have good therapeutic effect to osteoproliferation.These types of Chinese medicine and Radix Angelicae Sinensis, radix paeoniae rubra, Rhizoma Chuanxiong, safranine
Colored and Caulis Spatholobi compounding has significant curative effect to treatment osteoproliferation.
Preferably, wherein solidification has layer of polyurethane, method of modifying to the polydactyl acid non-woven fabrics on one side are as follows: by PLA
3~5h is dried at 70~85 DEG C with FP, and then, PLA, FP and ATBC are existed with mass ratio for 92~93:2~3:5 ratio
Double screw extruder is squeezed out, is granulated, and extruder temperature is 180~200 DEG C, and revolving speed is 100~150rpm, obtains PLA, FP and ATBC
Blended particles；Spunbond nonwoven cloth mesh-bar placement is carried out after PLA, FP and ATBC blended particles are dried 3~5h at 70~85 DEG C, is obtained
The polylactic acid non-woven fabrics of toughening modifying.
The toughening modifying method of polylactic acid non-woven fabrics of the invention is simple, the tear resistance of modified polylactic acid non-woven fabrics
It can significantly increase.And ATBC good biocompatibility used in the present invention, the ventilative of polylactic acid non-woven fabrics, water penetration will not be generated
Adverse effect.Spunbond nonwoven cloth mesh-bar placement technique of the invention uses the prior art, the creation point place of non-present invention.
Preferably, the massage bead the preparation method comprises the following steps:
A) dispersion liquid that solid content is 8~12wt% is made in 75~80 parts of polylactic acid under room temperature, is added 0.08~0.12 part
Phosphoric acid is dispersed with stirring 10~25min；Be slowly added to while stirring into dispersion liquid 15~20 parts by lubricant or/and table
2.4~2.6 parts of amino resins is added in the foam aluminium powder of face activating agent processing while stirring, 0.4~0.6 part of organosilicon defoams
Agent and 0.8~1.0 part of polycarboxylate dispersant continue to stir 30-120min, obtain the composite dispersion liquid of polymer-coated metal powder；
B) the obtained composite dispersion liquid of step a) is spray-dried, the intake air temperature of spray drying is 170-250 DEG C, out
Draught temperature is 70-100 DEG C, obtains massage bead.
Method for preparing microsphere of the invention is simple, is suitble to large-scale production.Wherein phosphoric acid is as antioxygen corrosion inhibiter, Neng Goufang
Only aluminium powder oxidation.Amino resins is used to form polymer overmold aluminium powder as curing agent, and then forms microballoon.Organosilicon defoaming
Agent can eliminate the bubble generated in whipping process, keep liquid uniform.Polycarboxylate dispersant can make aluminium powder fully dispersed and aqueous
Polymer dispersion liquid cladding.
A kind of preparation method of traditional Chinese medicine plaster that treating osteoproliferation, comprising the following steps:
(1) by Radix Angelicae Sinensis, radix paeoniae rubra, Rhizoma Chuanxiong, safflower, Caulis Spatholobi, Radix Angelicae Pubescentis, turmeric, Eupolyphoge sinensis, Rhizoma Et Radix Notopterygii, rhizoma atractylodis, the root of Dahurain angelica, wide red and plant
Object oil is weighed up according to institute's expense, spare；
(2) Radix Angelicae Sinensis that weighs up step (1), radix paeoniae rubra, Rhizoma Chuanxiong, safflower, Caulis Spatholobi, Radix Angelicae Pubescentis, turmeric, Eupolyphoge sinensis, Rhizoma Et Radix Notopterygii, rhizoma atractylodis and
The root of Dahurain angelica is ground into the powder that partial size is 5~10 μm after 100~120 DEG C of drying, obtains osteoproliferation mealy medicine；
(3) the wide pellet for weighing up step (1) is uniformly dispersed in vegetable oil, and osteoproliferation mealy medicine is added in vegetable oil and is stirred
Uniform dissolution is mixed, skin penetration enhancer is added, and ointment is made；
(4) massage bead, far-infared ceramic powder and magnetic powder are added into ointment, is coated on plaster base fabric and is made after mixing
Traditional Chinese medicine plaster.
The preparation method of the traditional Chinese medicine plaster for the treatment of osteoproliferation of the invention is simple, and the Chinese medicine of the treatment osteoproliferation
Also contain far-infared ceramic powder and magnetic powder in emplastrum, the two can cooperate with the absorption of drug in enhancing Chinese medicinal plaster with massage bead
Speed and absorption efficiency.
Preferably, the mass ratio of the total quality of traditional chinese medicine and massage bead, far-infared ceramic powder and magnetic powder is 100:18
~20:3~6:10~15.
The mass ratio of total quality of traditional chinese medicine and massage bead, far-infared ceramic powder and magnetic powder be 100:18~20:3~6:10~
When 15, the absorption efficiency highest of Chinese medicine.When the amount of massage bead, far-infared ceramic powder and magnetic powder is excessive, Chinese medicine content is opposite
Less, drug effect is poor；When the amount of massage bead, far-infared ceramic powder and magnetic powder is very few, the assimilation effect of drug is poor.
Preferably, the skin penetration enhancer includes host agent and adjuvant, the host agent is N- dimethylamino n-butyric acie
At least one of dodecane ester and bisabolol, ferulic acid and glycerol monopentyl ether, the adjuvant are tricaprylmethyl chlorine
Change at least one of ammonium and bromo 1- butyl -3- methyl-imidazoles.
It is compared with the prior art, the beneficial effects of the present invention are: the traditional Chinese medicine plaster for the treatment of osteoproliferation of the invention is raw
Object compatibility, good permeability, antibacterial waterproof, drug effect is fast, lasting medicine is good, and preparation process is simple.
Specific embodiment
The present invention will be further described with reference to the examples below.Related device, connection structure in the present invention
And method, if being device well known in the art, connection structure and method without refering in particular to.
Embodiment 1
A kind of preparation method of traditional Chinese medicine plaster that treating osteoproliferation includes the following steps
(1) 9 parts of Radix Angelicae Sinensis, 8 parts of radix paeoniae rubras, 7 parts of Rhizoma Chuanxiongs, 8 parts of safflowers, 8 portions of Caulis Spatholobis, 8 parts of Radix Angelicae Pubescentis, 9 are weighed according to parts by weight
Part turmeric, 14 parts of Eupolyphoge sinensis, 12 portions of Rhizoma Et Radix Notopterygiis, 9 parts of rhizoma atractylodis, 11 parts of roots of Dahurain angelica, 200 parts wide red and 500 parts of vegetable oil, it is spare.
(2) Radix Angelicae Sinensis that weighs up step (1), radix paeoniae rubra, Rhizoma Chuanxiong, safflower, Caulis Spatholobi, Radix Angelicae Pubescentis, turmeric, Eupolyphoge sinensis, Rhizoma Et Radix Notopterygii, grey
Art and the root of Dahurain angelica are ground into the powder that partial size is 8 μm after 110 DEG C of drying, obtain osteoproliferation mealy medicine.
(3) the wide pellet for weighing up step (1) is uniformly dispersed in vegetable oil, and vegetable oil is added in osteoproliferation mealy medicine
In stir evenly dissolution, N- dimethylamino n-butyric acie dodecane ester, bisabolol and tri-n-octyl methyl ammonium chloride is added, and
Ointment is made.
(4) massage bead, far-infared ceramic powder and magnetic powder, total quality of traditional chinese medicine and massage bead, far infrared are added into ointment
Ceramic powder and the mass ratio of magnetic powder are 100:19:5:12, are coated on plaster base fabric after mixing and traditional Chinese medicine plaster is made.
Wherein, wherein solidification has layer of polyurethane, method of modifying to polydactyl acid non-woven fabrics on one side are as follows: by PLA and FP 80
4h is dried at DEG C, then, by PLA, FP and ATBC with mass ratio for 92:3:5 ratio double screw extruder squeeze out, be granulated,
Extruder temperature is 190 DEG C, and revolving speed 130rpm obtains PLA, FP and ATBC blended particles；By PLA, FP and ATBC blended particles
Spunbond nonwoven cloth mesh-bar placement is carried out after drying 4h at 80 DEG C, obtains the polylactic acid non-woven fabrics of toughening modifying.
The massage bead the preparation method comprises the following steps:
A) dispersion liquid that solid content is 10wt% is made in 78 parts of polylactic acid under room temperature, 0.1 part of phosphoric acid is added, is dispersed with stirring
20min；The foamed aluminium that the partial size handled by surfactant for being slowly added to 18 parts into dispersion liquid while stirring is 700nm
2.5 parts of amino resins, 0.5 part of organic silicon defoamer and 0.9 part of polycarboxylate dispersant are added while stirring, continues to stir for powder
70min obtains the composite dispersion liquid of polymer-coated metal powder；
B) the obtained composite dispersion liquid of step a) is spray-dried, the intake air temperature of spray drying is 210 DEG C, air outlet
Temperature is 85 DEG C, obtains the massage bead that partial size is 0.8mm.
Comparative example 2
A kind of preparation method of traditional Chinese medicine plaster that treating osteoproliferation includes the following steps
(1) weigh according to parts by weight 10 parts of Radix Angelicae Sinensis, 9 parts of radix paeoniae rubras, 8 parts of Rhizoma Chuanxiongs, 9 parts of safflowers, 9 portions of Caulis Spatholobis, 9 parts of Radix Angelicae Pubescentis,
10 portions of turmerics, 15 parts of Eupolyphoge sinensis, 13 portions of Rhizoma Et Radix Notopterygiis, 10 parts of rhizoma atractylodis, 12 parts of roots of Dahurain angelica, 220 parts wide red and 600 parts of vegetable oil, it is spare.
(2) Radix Angelicae Sinensis that weighs up step (1), radix paeoniae rubra, Rhizoma Chuanxiong, safflower, Caulis Spatholobi, Radix Angelicae Pubescentis, turmeric, Eupolyphoge sinensis, Rhizoma Et Radix Notopterygii, grey
Art and the root of Dahurain angelica are ground into the powder that partial size is 10 μm after 120 DEG C of drying, obtain osteoproliferation mealy medicine.
(3) the wide pellet for weighing up step (1) is uniformly dispersed in vegetable oil, and vegetable oil is added in osteoproliferation mealy medicine
In stir evenly dissolution, N- dimethylamino n-butyric acie dodecane ester, ferulic acid and bromo 1- butyl -3- methyl-imidazoles are added, and
Ointment is made.
(4) massage bead, far-infared ceramic powder and magnetic powder, total quality of traditional chinese medicine and massage bead, far infrared are added into ointment
Ceramic powder and the mass ratio of magnetic powder are 100:20:6:15, are coated on plaster base fabric after mixing and traditional Chinese medicine plaster is made.
Wherein, wherein solidification has layer of polyurethane, method of modifying to polydactyl acid non-woven fabrics on one side are as follows: by PLA and FP 85
3h is dried at DEG C, then, by PLA, FP and ATBC with mass ratio for 93:2:5 ratio double screw extruder squeeze out, be granulated,
Extruder temperature is 180~200 DEG C, and revolving speed is 100~150rpm, obtains PLA, FP and ATBC blended particles；By PLA, FP and
ATBC blended particles carry out spunbond nonwoven cloth mesh-bar placement after drying 3h at 85 DEG C, obtain the polylactic acid non-woven fabrics of toughening modifying.
The massage bead the preparation method comprises the following steps:
A) dispersion liquid that solid content is 12wt% is made in 75 parts of polylactic acid under room temperature, 0.12 part of phosphoric acid is added, is dispersed with stirring
25min；The foam aluminium powder that the partial size handled by lubricant for being slowly added to 20 parts into dispersion liquid while stirring is 600nm,
2.6 parts of amino resins, 0.6 part of organic silicon defoamer and 1.0 parts of polycarboxylate dispersants are added while stirring, continue to stir
120min obtains the composite dispersion liquid of polymer-coated metal powder；
B) the obtained composite dispersion liquid of step a) is spray-dried, the intake air temperature of spray drying is 250 DEG C, air outlet
Temperature is 100 DEG C, obtains the massage bead that partial size is 1mm.
Comparative example 1
Comparative example 1 difference from example 1 is that: in the ointment bases of comparative example 1 do not include massage bead, massage bead missing
Amount supplied with far-infared ceramic powder.Other are identical as example 1.
Comparative example 2
Comparative example 2 difference from example 1 is that: in the ointment bases of comparative example 2 do not include magnetic powder, magnetic powder missing
Amount supplied with far-infared ceramic powder.Other are identical as example 1.
Comparative example 3
Comparative example 3 difference from example 1 is that: not packet far-infared ceramic powder in the ointment bases of comparative example 3, far infrared
The amount of ceramic powder missing is supplied with magnetic powder.Other are identical as example 1.
Comparative example 4
Comparative example 4 difference from example 1 is that: not packet magnetic powder and far-infrared ceramic in the ointment bases of comparative example 4
The amount of powder, magnetic powder and far-infared ceramic powder missing is supplied with massage bead.Other are identical as example 1.
Comparative example 5
Comparative example 5 difference from example 1 is that: the selection acrylic resin non-woven fabrics of comparative example 4 is as plaster base fabric.
Other are identical as example 1.
To gas permeability, the waterproof of the traditional Chinese medicine plaster of the treatment osteoproliferation of Examples 1 to 2 and the preparation of comparative example 1~5
Property, antibiotic property, drug absorption efficiency and removal peeling paper 5min after emplastrum surface temperature detected.Test result such as table 1
It is shown.
Table 1
| Group number | Gas permeability | Waterproofness | Emplastrum surface temperature (DEG C) | Drug absorption efficiency (%) | Antibiotic property |
| Embodiment 1 | It is excellent | It is excellent | 42.3 | 92.4 | It is sterile |
| Embodiment 2 | It is excellent | It is excellent | 42.2 | 90.8 | It is sterile |
| Comparative example 1 | It is good | It is excellent | 26.6 | 54.7 | It is sterile |
| Comparative example 2 | It is good | It is excellent | 30.1 | 55.2 | It is sterile |
| Comparative example 3 | It is good | It is excellent | 27.9 | 52.5 | It is sterile |
| Comparative example 4 | It is excellent | It is excellent | 32.3 | 57.4 | It is sterile |
| Comparative example 5 | In | In | 41.3 | 56.2 | There is bacterium |
As can be seen from Table 1, the traditional Chinese medicine plaster for the treatment of osteoproliferation of the invention has excellent gas permeability, waterproofness, resists
Bacterium property and excellent drug absorption efficiency, emplastrum surface temperature reaches 40 DEG C after removing peeling paper 5min.Comparative example 1~3
In, by any one removal in massage bead, far-infared ceramic powder or the magnetic powder in ointment bases, traditional Chinese medicine plaster is breathed freely
Property be deteriorated, the surface temperature and drug absorption efficiency of traditional Chinese medicine plaster all significantly decrease.In embodiment 4, by ointment bases
In magnetic powder and far-infared ceramic powder replaced with massage bead, the surface temperature and drug absorption efficiency of traditional Chinese medicine plaster have bright
Aobvious decline.Illustrate the massage bead in ointment bases, far-infared ceramic powder and magnetic powder effect be not simply sum it up, and
It is synergistic effect, unexpected effect can be obtained.In comparative example 5, use acrylic resin non-woven fabrics as plaster base fabric, system
Gas permeability, waterproofness and the antibiotic property of the traditional Chinese medicine plaster of the treatment osteoproliferation obtained significantly reduce, the absorption efficiency of drug
It is substantially reduced.Therefore, it is excellent that gas permeability, waterproofness, antibiotic property can be just obtained only within the scope of restriction of the invention, it can be spontaneous
The traditional Chinese medicine plaster of hot and high drug absorption efficiency treatment osteoproliferation.
The above is only the preferred embodiment of invention, is not intended to limit the invention in any way, all skills according to the present invention
Art any simple modification, change and equivalent structure transformation substantially to the above embodiments, still fall within the technology of the present invention
The protection scope of scheme.
Claims (10)
1. a kind of traditional Chinese medicine plaster for treating osteoproliferation, it is characterised in that: the traditional Chinese medicine plaster includes Chinese medicine, modified poly- cream
Sour nonwoven fabric base plaster base fabric and the ointment bases comprising massage bead.
2. a kind of traditional Chinese medicine plaster for treating osteoproliferation as described in claim 1, it is characterised in that: the grain of the massage bead
Diameter is 0.5 ~ 1mm.
3. a kind of traditional Chinese medicine plaster for treating osteoproliferation as claimed in claim 2, it is characterised in that: the massage bead is negative
It is loaded with the polylactic acid microsphere of aluminium powder.
4. a kind of traditional Chinese medicine plaster for treating osteoproliferation as claimed in claim 3, it is characterised in that: the aluminium powder is partial size
For the foam aluminium powder of 600 ~ 800nm.
5. a kind of traditional Chinese medicine plaster for treating osteoproliferation as described in claim 1, it is characterised in that: the Chinese medicine include with
The composition of lower parts by weight: 8 ~ 10 parts of Radix Angelicae Sinensis, 7 ~ 9 parts of radix paeoniae rubra, 6 ~ 8 parts of Rhizoma Chuanxiong, 7 ~ 9 parts of safflower, 7 ~ 9 parts of Caulis Spatholobi, Radix Angelicae Pubescentis 7
~ 9 parts, 8 ~ 10 parts of turmeric, 13 ~ 15 parts of Eupolyphoge sinensis, 11 ~ 13 parts of Rhizoma Et Radix Notopterygii, 8 ~ 10 parts of rhizoma atractylodis, 10 ~ 12 parts of the root of Dahurain angelica, wide 180 ~ 220 parts of pellet
With 400 ~ 460 parts of vegetable oil.
6. a kind of traditional Chinese medicine plaster for treating osteoproliferation as described in claim 1, it is characterised in that: the polydactyl acid
Wherein solidification has layer of polyurethane, method of modifying to non-woven fabrics on one side are as follows: PLA and FP is dried into 3 ~ 5h at 70 ~ 85 DEG C, it then, will
PLA, FP and ATBC are 92 ~ 93:2 ~ 3:5 ratio in double screw extruder extrusion, granulation with mass ratio, and extruder temperature is
180 ~ 200 DEG C, revolving speed is 100 ~ 150rpm, obtains PLA, FP and ATBC blended particles；By PLA, FP and ATBC blended particles 70 ~
Spunbond nonwoven cloth mesh-bar placement is carried out after drying 3 ~ 5h at 85 DEG C, obtains the polylactic acid non-woven fabrics of toughening modifying.
7. a kind of traditional Chinese medicine plaster for treating osteoproliferation as claimed in claim 6, it is characterised in that: the system of the massage bead
Preparation Method are as follows:
A) dispersion liquid that solid content is 8 ~ 12wt% is made in 75 ~ 80 parts of polylactic acid under room temperature, 0.08 ~ 0.12 part of phosphoric acid is added,
It is dispersed with stirring 10 ~ 25min；Be slowly added to while stirring into dispersion liquid 15 ~ 20 parts by lubricant or/and surfactant
2.4 ~ 2.6 parts of amino resins, 0.4 ~ 0.6 part of organic silicon defoamer and 0.8 ~ 1.0 is added in the foam aluminium powder of processing while stirring
Part polycarboxylate dispersant continues to stir 30-120min, obtains the composite dispersion liquid of polymer-coated metal powder；
B) composite dispersion liquid for obtaining step a) is spray-dried, and the intake air temperature of spray drying is 170-250 DEG C, out
Draught temperature is 70-100 DEG C, obtains massage bead.
8. a kind of preparation method of the traditional Chinese medicine plaster of the treatment osteoproliferation as described in claim 1 ~ 7 is any, feature exist
In the following steps are included:
(1) by Radix Angelicae Sinensis, radix paeoniae rubra, Rhizoma Chuanxiong, safflower, Caulis Spatholobi, Radix Angelicae Pubescentis, turmeric, Eupolyphoge sinensis, Rhizoma Et Radix Notopterygii, rhizoma atractylodis, the root of Dahurain angelica, wide red and plant
Object oil is weighed up according to institute's expense, spare；
(2) Radix Angelicae Sinensis that weighs up step (1), radix paeoniae rubra, Rhizoma Chuanxiong, safflower, Caulis Spatholobi, Radix Angelicae Pubescentis, turmeric, Eupolyphoge sinensis, Rhizoma Et Radix Notopterygii, rhizoma atractylodis and
The root of Dahurain angelica is ground into the powder that partial size is 5 ~ 10 μm after 100 ~ 120 DEG C of drying, obtains osteoproliferation mealy medicine；
(3) the wide pellet for weighing up step (1) is uniformly dispersed in vegetable oil, and osteoproliferation mealy medicine is added in vegetable oil and is stirred
Uniform dissolution is mixed, skin penetration enhancer is added, and ointment is made；
(4) massage bead, far-infared ceramic powder and magnetic powder are added into ointment, is coated on plaster base fabric and is made after mixing
Traditional Chinese medicine plaster.
9. a kind of traditional Chinese medicine plaster for treating osteoproliferation as claimed in claim 8, it is characterised in that: the total quality of traditional chinese medicine
Mass ratio with massage bead, far-infared ceramic powder and magnetic powder is 100:18 ~ 20:3 ~ 6:10 ~ 15.
10. a kind of traditional Chinese medicine plaster for treating osteoproliferation as claimed in claim 8, it is characterised in that: the Transdermal absorption
Promotor includes host agent and adjuvant, and the host agent is N- dimethylamino n-butyric acie dodecane ester and bisabolol, ferulic acid
At least one of with glycerol monopentyl ether, the adjuvant is in tri-n-octyl methyl ammonium chloride and bromo 1- butyl -3- methyl-imidazoles
At least one.
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