CN109464559A - A kind of traditional Chinese medicine plaster of resisting cardiovascular disease - Google Patents
A kind of traditional Chinese medicine plaster of resisting cardiovascular disease Download PDFInfo
- Publication number
- CN109464559A CN109464559A CN201811260275.3A CN201811260275A CN109464559A CN 109464559 A CN109464559 A CN 109464559A CN 201811260275 A CN201811260275 A CN 201811260275A CN 109464559 A CN109464559 A CN 109464559A
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- chinese medicine
- plaster
- cardiovascular disease
- traditional chinese
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- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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Abstract
The present invention relates to plaster technical fields, disclose a kind of traditional Chinese medicine plaster of resisting cardiovascular disease.The traditional Chinese medicine plaster of the resisting cardiovascular disease includes the plaster base fabric of Chinese medicine lotion and carrying Chinese medicine lotion.The Chinese medicine lotion includes the Chinese medicine of 19.5 ~ 20.2wt% and the ointment bases of 79.8 ~ 80.5wt%.The plaster base fabric includes outer layer made of internal layer made of polylactic acid non-woven fabrics and polyurethane film.And there are the microballoon, far-infared ceramic powder and magnetic powder of aluminium powder in ointment bases comprising load.Biocompatibility, the good permeability of the traditional Chinese medicine plaster of resisting cardiovascular disease of the invention, energy spontaneous heating, energy antibacterial waterproof, drug effect is fast, volatile performance is low, lasting medicine is good, and preparation process is simple.Solve the problems, such as that the traditional Chinese medicine plaster poor air permeability of current resisting cardiovascular disease, Yi Zhimin, drug absorption efficiency are poor.
Description
Technical field
The present invention relates to plaster technical field more particularly to a kind of traditional Chinese medicine plasters of resisting cardiovascular disease.
Background technique
Cardiovascular and cerebrovascular disease is the general designation of cardiovascular and cranial vascular disease, is a kind of to seriously threaten human life and health
Disease.Traditional common medicine for the treatment of cardio-cerebralvascular patient has Chinese medicine, Chinese patent drug, capsule, tablet, injection etc..Traditional note
It is big administration modes toxicity caused by body such as to penetrate, take orally, and drug reaches whole body by blood circulation, really reaching key portion
The dose of position is few.Plaster is avoided that endo-medicine bring toxic side effect, and drug effect is high, it is obvious to take effect.However, existing plaster exists
Problem used below: one, plaster absorption efficiency is low, medication cycle is long；Two, plaster thickness is thin, bad adhesion, and plaster covering is such as
The packaging effect of peeling paper etc. is bad and easy dampness；Three, plaster poor air permeability.
Chinese patent Authorization Notice No. is the patent of CN101912493B, discloses and a kind of treats cardio-cerebralvascular diseases cave
Position emplastrum.The acupoint plaster is made of head acupuncture point emplastrum, upper limb acupoint plaster and lower limb acupoint plaster, in use, three kinds of medicines
Emplastrum is affixed on corresponding acupuncture point simultaneously respectively.Acupoint plaster performance is stablized, easy to use, safe.However, the acupoint plaster is saturating
Gas, waterproof, antibiotic property are poor, and drug absorption efficiency is to be improved.
Summary of the invention
In order to solve the above-mentioned technical problems, the present invention provides a kind of traditional Chinese medicine plasters of resisting cardiovascular disease.This hair
Traditional Chinese medicine plaster biocompatibility, the good permeability of bright resisting cardiovascular disease, can spontaneous heating, can antibacterial waterproof, drug effect is fast,
Volatile performance is low, lasting medicine is good, and preparation process is simple.
The specific technical proposal of the invention is: a kind of traditional Chinese medicine plaster of resisting cardiovascular disease, the resisting cardiovascular
The traditional Chinese medicine plaster of disease includes the plaster base fabric of Chinese medicine lotion and carrying Chinese medicine lotion；The Chinese medicine lotion includes Chinese medicine mixing paste
Body matrix has the microballoon of aluminium powder in the ointment bases comprising load；The plaster base fabric includes made of polylactic acid non-woven fabrics
Outer layer made of internal layer and polyurethane film.
In the prior art, traditional Chinese medicine plaster surface layer is mostly made of acrylic resin or cotton.Although polyacrylic resin is malicious
The small, biocompatibility of property is also preferable, but after long-time use, will also result in patient skin redness itch.The good permeability of cotton,
But cotton is non-watertight, and the gap between cotton channels and collaterals is big, there is a problem of that ointment exudation, smell are pungent.
The plaster base fabric of the traditional Chinese medicine plaster of resisting cardiovascular disease of the invention is by polylactic acid non-woven fabrics and thin polyurethane
Film is made, and wherein polylactic acid non-woven fabrics is internal layer, and when use and skin contact, polyurethane film are outer layer, being capable of effective waterproof.
Plaster base fabric good permeability of the invention, good biocompatibility directly will not generate adverse reaction with skin contact, in addition, cream
The polylactic acid of medicine base fabric internal layer has natural anti-mite bacteriostasis, and pH and skin are close, can discharge go on a tour in use
From small molecule, the small molecule have extremely strong penetration power, with the lactic acid of this province of skin ining conjunction with after can not only effectively it is antibacterial,
The absorption efficiency of effective component in the traditional Chinese medicine plaster of the resisting cardiovascular disease can also be improved.Polylactic acid non-woven fabrics it is porous
Structure can allow air and water vapo r transmission, good permeability, and usage comfort is high.However, just because of polylactic acid non-woven fabrics it is ventilative,
Good water permeability causes its waterproofness very poor.In order to solve the disadvantage of polylactic acid non-woven fabrics waterproofness difference, the present invention polylactic acid without
Polyurethane film is provided on the outside of woven fabric.The waterproof performance of polyurethane film is excellent, while good permeability.By polylactic acid nonwoven
The plaster base fabric that cloth and polyurethane film collectively constitute not only has excellent ventilative, waterproof performance, while this can be promoted anti-
The absorption of effective component in the traditional Chinese medicine plaster of cardiovascular and cerebrovascular disease.
There is the microballoon of aluminium powder in ointment bases of the invention comprising load, when the Traditional Chinese medicine plaster using the resisting cardiovascular disease
When paste, the moisture in skin can enter microballoon and react with aluminium powder, generate hydrogen, while releasing heat.Due to depositing for microballoon
The reaction slowly occurs, and can continue to release hydrogen and heat.Hydrogen enters after skin the activity that can be improved cell, micro-
Heat can also improve cell activity, promote blood circulation, and then effective component in the traditional Chinese medicine plaster of promotion resisting cardiovascular disease
Absorption.
Preferably, the microballoon includes aluminium powder and the polylactic acid shell that is coated on outside aluminium powder.
The shell of microballoon of the invention is polylactic acid, and polylactic acid is permeable, good permeability, moisture content can not be made to enter microballoon
It is reacted with aluminium powder, while the gas permeability of ointment bases can be increased, improve the saturating of the traditional Chinese medicine plaster of the resisting cardiovascular disease
Gas and usage comfort.
Preferably, containing solid weak acid in the aluminium powder, the mass ratio of aluminium powder and solid weak acid is 4~10:1.
Contain a small amount of solid weak acid in aluminium powder of the invention, the oxidation on aluminium powder surface layer can be effectively prevent, enable aluminium powder
Enough lasting reacts with water.
Preferably, the microballoon the preparation method comprises the following steps:
A) according to parts by weight, the acetone soln that solid content is 8~12wt% is made in 78~82 parts of polylactic acid under room temperature, be added
0.08~0.12 part of phosphoric acid, is dispersed with stirring 10~25min；14~18 parts of surface is slowly added into dispersion liquid while stirring
2.4~2.6 parts of amino resins, 0.4~0.6 part of organic silicon defoamer and 0.8~1.0 is added in the aluminium powder of processing while stirring
Part polycarboxylate dispersant continues to stir 30-120min, obtains the composite dispersion liquid of polymer-coated metal powder；
B) the obtained composite dispersion liquid of step a) is spray-dried, obtains the microballoon of polymer-coated metal powder.
Method for preparing microsphere of the invention is simple, is suitble to large-scale production.Wherein phosphoric acid is as antioxygen corrosion inhibiter, Neng Goufang
Only aluminium powder oxidation.Amino resins is used to form polymer overmold aluminium powder as curing agent, and then forms microballoon.Organosilicon defoaming
Agent can eliminate the bubble generated in whipping process, keep liquid uniform.Polycarboxylate dispersant can make aluminium powder fully dispersed and aqueous
Polymer dispersion liquid cladding.
Preferably, the aluminium powder of the surface treatment is that metal powder passes through lubricant or/and surfactant in step a)
What processing obtained, processing method are as follows: the lubricant or/and surfactant solution that concentration is 0.4~0.6wt% is added in aluminium powder
Middle 15~25min of ultrasonic disperse, then in 55~65 DEG C of 2~3h of stirring, aluminium powder and lubricant or/and surfactant solution
Mass volume ratio is 1:3~5；The lubricant is at least one of stearic acid, metallic soap and atoleine, and the surface is living
Property agent be at least one of neopelex, lecithin and fatty acid sorbitan；In step b), the spray drying
Intake air temperature be 170-250 DEG C；Air outlet temperature is 70-100 DEG C.
The present invention is needed when preparing microballoon with lubricator or/and surfactant handles aluminium powder, to prevent aluminium
Powder ball is poly-, increases dispersibility of the aluminium powder in dispersion liquid.
Preferably, the mass percent of the Chinese medicine and ointment bases are as follows: Chinese medicine 19.5~20.2%, ointment bases
79.8~80.5%.
The weight percent of Chinese medicine and ointment bases is respectively as follows: in the traditional Chinese medicine plaster of resisting cardiovascular disease of the invention
19.5~20.2% and 79.8~80.5%.Chinese medicine proportion is excessive, will lead to the active principle in effective application time
It absorbs endless, causes to waste.The specific gravity of Chinese medicine is very few to be will be unable to reach ideal effect.
Preferably, the ointment bases include the composition of following parts by weight: 39~46 parts of medical thermoplastic elastomer (TPE),
15~29 parts of medical tackifier, 1~5 part of skin penetration enhancer, load the microballoon 7 for having aluminium powder at 20~38 parts of medical softening agent
~10 parts, 4~7 parts of filler zinc oxide, 0.6~1 part of far-infared ceramic powder, 7~8 parts of magnetic powder and 1~2 part of antioxidant.
Contain antioxidant in ointment bases of the invention, to prevent the oxidation of effective component.In addition, also containing in ointment bases
There is load to have the microballoon, far-infared ceramic powder and magnetic powder of aluminium powder.Load has the microballoon of aluminium powder that can increase the saturating of ointment bases
Gas, while the absorption of effective component in Chinese medicine can be promoted.Far-infared ceramic powder can give off more more than normal object
Far infrared, can active cell, relaxation vascular smooth muscle, enhancing blood vessel own circadian movement, so as to improve microcirculation in human body,
It boosts metabolism, balances body pH value and Repercusion analgesia.During far-infared ceramic powder and magnetic powder collocation can significantly increase
The absorption of pharmaceutically active ingredient.
Preferably, the Chinese medicine includes following components: 12-14 parts of Radix Angelicae Sinensis, 8-10 parts of Rhizoma Chuanxiong, 8-10 parts of leech, Eupolyphoge sinensis
8-10 parts, 4-6 parts of radix paeoniae rubra, 4-6 parts of peach kernel, 6-8 parts of safflower, 12-14 parts of pheretima, 7-9 parts of pueraria lobata, 18-20 parts of the root of Dahurain angelica, rhizoma acori graminei
10-12 parts, 10-12 parts of Radix Polygalae, 7-9 parts of rhizoma typhonii, 5-7 parts of arisaema cum bile, 5-8 parts of bombys batryticatus, 200-280 parts of wide pellet and vegetable oil
460-540 parts.
Include the drug of dredging the channel, activating microcirculation and removing stasis medicinal in Chinese medicine of the invention, also includes calm emotions, dispelling wind and relieving convulsion
The drug of drug and myogenic promoting blood circulation.Radix Angelicae Sinensis in drug of the invention, Rhizoma Chuanxiong, leech, Eupolyphoge sinensis, radix paeoniae rubra, peach kernel, safflower, pheretima and
Pueraria lobata all has effect promoting blood circulation and removing obstruction in channels, can promote the dissolution of thrombus, prevents the accumulation of fat.The root of Dahurain angelica has blood activating and promoting tissue regeneration
Effect, can promote the reparative regeneration of blood vessel, help to restore blood vessel elasticity.Rhizoma acori graminei, Radix Polygalae, rhizoma typhonii, arisaema cum bile and deadlock
Worm being capable of calm emotions.Chinese medicine compounding of the invention can stabilize the mind of user, promote thrombolysis and enhance vascular wall
Elasticity.
Preferably, the antioxidant is antioxidant BHT.The thermoplastic elastomer be styrenic thermoplastic elastomer,
At least one of polyester-type thermoplastic rubber, thermoplastic polyurethane；The tackifier are natural or synthetic resin, the day
So or synthetic resin is at least one of cyclopentadiene, isoprene, rosin, hydrogenated rosin, hydrogenated rosin glycerolipid；It is described
Softening agent be at least one of atoleine, lanolin, yellow petroleum jelly, vaseline；The skin penetration enhancer includes
Host agent and adjuvant, the host agent are N- dimethylamino n-butyric acie dodecane ester and bisabolol, ferulic acid and glycerol list penta
At least one of ether, the adjuvant are at least one in tri-n-octyl methyl ammonium chloride and bromo 1- butyl -3- methyl-imidazoles
Kind.
Preferably, the vegetable oil is at least one of sesame oil, rapeseed oil, cotton oil.
It is compared with the prior art, the beneficial effects of the present invention are: the traditional Chinese medicine plaster of resisting cardiovascular disease of the invention
There is the microballoon, remote of aluminium powder comprising load using polylactic acid non-woven fabrics and polyurethane film as plaster base fabric, and in ointment bases
Infrared ceramic powder and magnetic powder.Biocompatibility, the good permeability of the traditional Chinese medicine plaster of resisting cardiovascular disease of the invention, energy
Spontaneous heating, energy antibacterial waterproof, drug effect is fast, volatile performance is low, lasting medicine is good, and preparation process is simple.
Specific embodiment
The present invention will be further described with reference to the examples below.Related device, connection structure in the present invention
And method, if being device well known in the art, connection structure and method without refering in particular to.
Embodiment 1
A kind of traditional Chinese medicine plaster of resisting cardiovascular disease, the traditional Chinese medicine plaster including the resisting cardiovascular disease include Chinese medicine
The plaster base fabric of lotion and carrying Chinese medicine lotion；The Chinese medicine lotion includes the Chinese medicine of 19.8wt% and the lotion base of 80.2wt%
Matter has the microballoon of aluminium powder in the ointment bases comprising load；The plaster base fabric includes made of polydactyl acid non-woven fabrics
Outer layer made of internal layer and polyurethane film.
Microballoon the preparation method comprises the following steps:
A) acetone soln that solid content is 10wt% is made in 80 parts of polylactic acid under room temperature, 0.1 part of phosphoric acid is added, is dispersed with stirring
18min；16 parts of aluminium powders containing solid weak acid handled by stearic acid, aluminium are slowly added into dispersion liquid while stirring
The mass ratio of powder and solid weak acid is 7:1, and 2.5 parts of amino resins, 0.5 part of organic silicon defoamer and 0.9 are added while stirring
Part polycarboxylate dispersant continues to stir 75min, obtains the composite dispersion liquid of polymer-coated metal powder；Wherein, the processing side of aluminium powder
Method are as follows: ultrasonic disperse 20min in the stearic acid solution that concentration is 0.5wt% is added in aluminium powder, then in 60 DEG C of stirring 2.5h, aluminium
The mass volume ratio of powder and stearic acid solution is 1:4；
B) the obtained composite dispersion liquid of step a) is spray-dried, the intake air temperature of spray drying is 210 DEG C；Air outlet
Temperature is 85 DEG C, obtains the microballoon of polymer-coated metal powder.
Polydactyl acid non-woven fabrics the preparation method comprises the following steps: PLA and FP is dried 4h at 80 DEG C, then, by PLA, FP and
Ratio of the ATBC with mass ratio for 92:3:5 is squeezed out in double screw extruder, is granulated, and extruder temperature is 190 DEG C, and revolving speed is
130rpm obtains PLA, FP and ATBC blended particles；PLA, FP and ATBC blended particles are dried at 80 DEG C carry out after 4h it is spunbond
Nonwoven cloth mesh-bar placement obtains the polylactic acid non-woven fabrics of toughening modifying.
Polylactic acid non-woven fabrics is modified with FP and ATBC, and toughness dramatically increases, and anti-bursting and lear energy significantly increases.
The toughness of the plaster base fabric of modified polylactic acid non-woven fabrics preparation is strong, after use, removes conveniently.
A kind of preparation method of the traditional Chinese medicine plaster of resisting cardiovascular disease the following steps are included:
(1) glue: by 42 parts of styrenic thermoplastic elastomers, 22 parts of cyclopentadiene, 1.5 parts of antioxidant BHTs, 0.8 part of far infrared
Ceramic powder, 7.5 parts of magnetic powders throw and obtain the rubber sheet of 0.9mm thickness in rubber mixing machine roll-in, are subsequently placed in blender and are added
The mixed solvent of the ethyl alcohol of the gasoline and 18wt% of 82wt% carries out immersion swelling, the mass ratio of rubber sheet and mixed solvent
For 1:8.
(2) ingredient: 240 parts wide pellet being dissolved in 500 parts of sesame oil and is stirred evenly, by 13 parts of Radix Angelicae Sinensis, 9 parts of Rhizoma Chuanxiongs, 9 parts of water
Leech, 9 parts of Eupolyphoge sinensis, 5 parts of radix paeoniae rubras, 5 parts of peach kernels, 7 parts of safflowers, 13 parts of pheretimas, 8 parts of pueraria lobatas, 19 parts of roots of Dahurain angelica, 11 parts of rhizoma acori gramineis, 11 parts
Radix Polygalae, 8 parts of rhizoma typhoniis, 6 parts of arisaema cum bile, 6 portions of bombys batryticatus, which are ground to be added in sesame oil after nano-scale particle, stirs evenly dissolution, by 1
Part N- dimethylamino n-butyric acie dodecane ester, 1 part of bisabolol, 1 part of tri-n-octyl methyl ammonium chloride, 5.5 parts of filler oxygen
Change zinc, 29 parts of vaseline sequentially add and are uniformly mixing to obtain mixed liquor in sesame oil.
(3) it is beaten: the rubber sheet after swelling being cut into the rubber segments that length is less than 1cm, adhesive supplier is put into, is then added
It mixes feed liquid and stirs gluing, be sieved to obtain rubber cement through sieve, the feed liquid that sieve retains is again returned into gluing.
(4) it is homogenized: rubber cement being sent into high-shear homogenizer with the revolving speed homogenization of 9000r/min, slurry is obtained, to slurry
9 parts of loads are added in material has the microballoon of aluminium powder to stir evenly, and obtains the slurry containing microballoon.
(5) gluing: plaster base fabric being sent into two roll-in cylinders of glue spreader, is added the slurry containing microballoon to glue spreader and is applied
It overlays on plaster base fabric and paste is made.
(6) spool: heating beamer, and temperature is respectively as follows: 60 DEG C of first of oven temperature at each baking oven in control beamer,
90 DEG C of second oven temperature, 70 DEG C of third road oven temperature handles paste spool.
(7) paster: peeling paper is closed in the plaster face paste of paste, in peeling paper outer application volatilization trapping layer, volatilization is prevented
Layer is sprayed by the component mixing of following parts by weight: 7 parts of hydroxypropyl methyl cellulose, 3 parts of carob, 50 parts of ethyl alcohol, water
75 parts, thickness is 3 μm.
(8) encapsulate: bagging encapsulates to obtain the traditional Chinese medicine plaster of resisting cardiovascular disease after being sliced by predetermined size.
Embodiment 2
A kind of traditional Chinese medicine plaster of resisting cardiovascular disease, the traditional Chinese medicine plaster including the resisting cardiovascular disease include Chinese medicine
The plaster base fabric of lotion and carrying Chinese medicine lotion；The Chinese medicine lotion includes the Chinese medicine of 19.5wt% and the lotion base of 80.5wt%
Matter has the microballoon of aluminium powder in the ointment bases comprising load；The plaster base fabric includes internal layer made of polylactic acid non-woven fabrics
With outer layer made of polyurethane film.
Microballoon the preparation method comprises the following steps:
A) acetone soln that solid content is 8wt% is made in 78 parts of polylactic acid under room temperature, 0.08 part of phosphoric acid is added, is dispersed with stirring
10min；Be slowly added to while stirring into dispersion liquid 14 parts by neopelex handle containing solid it is weak
The mass ratio of the aluminium powder of acid, aluminium powder and solid weak acid is 4:1, the amino resins, 0.4 part of organosilicon of 2.4 parts of addition while stirring
Defoaming agent and 0.8 part of polycarboxylate dispersant continue to stir 30min, obtain the composite dispersion liquid of polymer-coated metal powder；Wherein,
The processing method of aluminium powder are as follows: ultrasonic disperse in the neopelex solution that concentration is 0.4wt% is added in aluminium powder
25min, then in 65 DEG C of stirring 2h, the mass volume ratio of aluminium powder and neopelex solution is 1:5；
B) the obtained composite dispersion liquid of step a) is spray-dried, the intake air temperature of spray drying is 170 DEG C；Air outlet
Temperature is 70 DEG C, obtains the microballoon of polymer-coated metal powder.
A kind of preparation method of the traditional Chinese medicine plaster of resisting cardiovascular disease the following steps are included:
(1) glue: by 39 parts of polyester-type thermoplastic rubber, 15 parts of isoprene, 1 part of antioxidant BHT, 0.6 part of far-infrared ceramic
Powder, 7 parts of magnetic powders are thrown and obtain the rubber sheet of 0.13mm thickness in rubber mixing machine roll-in, are subsequently placed in blender and 95wt% is added
Gasoline and 5wt% ethyl alcohol mixed solvent, carry out immersion swelling, the mass ratio of rubber sheet and mixed solvent is 1:10.
(2) ingredient: wide red 200 parts being dissolved in 460 parts of rapeseed oil and is stirred evenly, by 12 parts of Radix Angelicae Sinensis, 8 parts of Rhizoma Chuanxiongs, 9 parts of water
Leech, 9 parts of Eupolyphoge sinensis, 4 parts of radix paeoniae rubras, 4 parts of peach kernels, 6 parts of safflowers, 12 parts of pheretimas, 7 parts of pueraria lobatas, 18 parts of roots of Dahurain angelica, 10 parts of rhizoma acori gramineis, 10 parts
Radix Polygalae, 7 parts of rhizoma typhoniis, 5 parts of arisaema cum bile, 5 portions of bombys batryticatus, which are ground to be added in rapeseed oil after nano-scale particle, stirs evenly dissolution, general
0.5 part of N- dimethylamino n-butyric acie dodecane ester of transdermal enhancer, 0.2 part of ferulic acid, 0.3 part of bromo 1- butyl -3- methyl-miaow
Azoles, 4 parts of filler zinc oxide, 20 parts of atoleines sequentially add and are uniformly mixing to obtain mixed liquor in rapeseed oil.
(3) it is beaten: the rubber sheet after swelling being cut into the rubber segments that length is less than 1cm, then is put into adhesive supplier, then
It is added and mixes feed liquid stirring gluing, be sieved to obtain rubber cement through sieve, the feed liquid that sieve retains is again returned into gluing.
(4) it is homogenized: rubber cement being sent into high-shear homogenizer, revolving speed 8000r/min homogenization is kept to obtain slurry, to slurry
7 parts of loads are added in material has the microballoon of aluminium powder to stir evenly, and obtains the slurry containing microballoon.
(5) gluing: plaster base fabric being sent into two roll-in cylinders of glue spreader, is added the slurry containing microballoon to glue spreader and is applied
It overlays on plaster base fabric and paste is made.
(6) spool: heating beamer, and temperature is respectively as follows: 55 DEG C of first of oven temperature at each baking oven in control beamer,
85 DEG C of second oven temperature, 65 DEG C of third road oven temperature handles paste spool.
(7) paster: peeling paper is closed in the plaster face paste of paste, in peeling paper outer application volatilization trapping layer, volatilization is prevented
Layer is sprayed by the component mixing of following parts by weight: 4 parts of hydroxypropyl methyl cellulose, 10 parts of carob, 40 parts of ethyl alcohol, water 60
Part, thickness is 5 μm.
(8) encapsulate: bagging encapsulates to obtain the traditional Chinese medicine plaster of resisting cardiovascular disease after being sliced by predetermined size.
Embodiment 3
Embodiment 3 difference from example 1 is that: the plaster base fabric packet of the traditional Chinese medicine plaster of the resisting cardiovascular disease
Include outer layer made of internal layer made of polylactic acid non-woven fabrics and polyurethane film.Other are same as Example 1.
Comparative example 1
Comparative example 1 difference from example 1 is that: not including load in the ointment bases of comparative example 1 has the microballoon of aluminium powder,
The amount of microballoon missing is supplied with far-infared ceramic powder.Other are identical as example 1.
Comparative example 2
Comparative example 2 difference from example 1 is that: in the ointment bases of comparative example 2 do not include magnetic powder, magnetic powder missing
Amount supplied with far-infared ceramic powder.Other are identical as example 1.
Comparative example 3
Comparative example 3 difference from example 1 is that: not packet far-infared ceramic powder in the ointment bases of comparative example 3, far infrared
The amount of ceramic powder missing is supplied with magnetic powder.Other are identical as example 1.
Comparative example 4
Comparative example 4 difference from example 1 is that: not packet magnetic powder and far-infrared ceramic in the ointment bases of comparative example 4
The amount of powder, magnetic powder and far-infared ceramic powder missing is supplied with microballoon.Other are identical as example 1.
Comparative example 5
Comparative example 5 difference from example 1 is that: the plaster base fabric of comparative example 4 selects acrylic resin non-woven fabrics to replace
Polylactic acid non-woven fabrics and polyurethane film.Other are identical as example 1.
To gas permeability, the waterproof of the traditional Chinese medicine plaster of the resisting cardiovascular disease of Examples 1 to 3 and the preparation of comparative example 1~5
Property, antibiotic property, drug absorption efficiency and removal peeling paper 15min after emplastrum surface temperature detected.Test result such as table 1
It is shown.
Table 1
| Group number | Gas permeability | Waterproofness | Emplastrum surface temperature (DEG C) | Drug absorption efficiency (%) | Antibiotic property |
| Embodiment 1 | It is excellent | It is excellent | 40.3 | 90.2 | It is sterile |
| Embodiment 2 | It is excellent | It is excellent | 40.2 | 89.5 | It is sterile |
| Embodiment 3 | It is excellent | It is excellent | 40.2 | 89.9 | It is sterile |
| Comparative example 1 | It is good | It is excellent | 26.6 | 55.4 | It is sterile |
| Comparative example 2 | It is good | It is excellent | 29.1 | 56.3 | It is sterile |
| Comparative example 3 | It is good | It is excellent | 27.9 | 50.6 | It is sterile |
| Comparative example 4 | It is excellent | It is excellent | 31.3 | 58.1 | It is sterile |
| Comparative example 5 | In | In | 40.3 | 57.6 | There is bacterium |
As can be seen from Table 1, the traditional Chinese medicine plaster of resisting cardiovascular disease of the invention have excellent gas permeability, waterproofness,
Antibiotic property and excellent drug absorption efficiency, emplastrum surface temperature reaches 40 DEG C after removing peeling paper 15min.Comparative example 1
In~3, the load in ointment bases there are into any one removal in the microballoon, far-infared ceramic powder or magnetic powder of aluminium powder, patch
The gas permeability of paste is deteriorated, and the surface temperature and drug absorption efficiency of emplastrum all significantly decrease.In comparative example 4, by cream
Magnetic powder and far-infared ceramic powder in body matrix have the microballoon of aluminium powder to replace with load, and the surface temperature and drug of emplastrum are inhaled
Rate of producing effects all significantly decreases.Illustrate that the load in ointment bases has the microballoon of aluminium powder, far-infared ceramic powder and magnetic powder
Effect is not simply to sum it up, but have complementary synergistic effect, can obtain unexpected effect.Comparative example
In 5, plaster base fabric made of polylactic acid non-woven fabrics and polyurethane film is replaced with acrylic resin non-woven fabrics, the anti-heart obtained
Gas permeability, waterproofness and the antibiotic property of the traditional Chinese medicine plaster of cranial vascular disease significantly reduce, and the absorption efficiency of drug also obviously drops
It is low.Therefore, it is excellent that gas permeability, waterproofness, antibiotic property can be just obtained only within the scope of restriction of the invention, it can spontaneous heating and medicine
The traditional Chinese medicine plaster of the high resisting cardiovascular disease of object absorption efficiency.
The above is only the preferred embodiment of invention, is not intended to limit the invention in any way, all skills according to the present invention
Art any simple modification, change and equivalent structure transformation substantially to the above embodiments, still fall within the technology of the present invention
The protection scope of scheme.
Claims (10)
1. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease, it is characterised in that: the Chinese medicinal plaster of the resisting cardiovascular disease
Agent includes the plaster base fabric of Chinese medicine lotion and carrying Chinese medicine lotion；The Chinese medicine lotion includes Chinese medicine and ointment bases, the cream
There is the microballoon of aluminium powder in body matrix comprising load；The plaster base fabric includes internal layer made of polylactic acid non-woven fabrics and thin polyurethane
Outer layer made of film.
2. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease as described in claim 1, it is characterised in that: the microballoon includes
Aluminium powder and the polylactic acid shell being coated on outside aluminium powder.
3. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease as claimed in claim 2, it is characterised in that: contain in the aluminium powder
There is solid weak acid, the mass ratio of aluminium powder and solid weak acid is 4 ~ 10:1.
4. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease as described in claim 1 ~ 3 is any, it is characterised in that: described micro-
Ball the preparation method comprises the following steps:
A) according to parts by weight, the acetone soln that solid content is 8 ~ 12wt% is made in 78 ~ 82 parts of polylactic acid under room temperature, be added
0.08 ~ 0.12 part of phosphoric acid, is dispersed with stirring 10 ~ 25min；It is slowly added to while stirring into dispersion liquid at 14 ~ 18 parts of surface
2.4 ~ 2.6 parts of amino resins, 0.4 ~ 0.6 part of organic silicon defoamer and 0.8 ~ 1.0 part of poly- carboxylic is added in the aluminium powder of reason while stirring
Acid dispersant continues to stir 30-120min, obtains the composite dispersion liquid of polymer-coated metal powder；
B) composite dispersion liquid for obtaining step a) is spray-dried, and obtains the microballoon of polymer-coated metal powder.
5. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease as claimed in claim 4, it is characterised in that: in step a), institute
State what the aluminium powder of surface treatment was handled for metal powder by lubricant or/and surfactant, processing method are as follows: by aluminium powder
15 ~ 25min of ultrasonic disperse in the lubricant or/and surfactant solution that concentration is 0.4 ~ 0.6wt% is added, then 55 ~ 65
The mass volume ratio of DEG C 2 ~ 3h of stirring, aluminium powder and lubricant or/and surfactant solution is 1:3 ~ 5；The lubricant is hard
At least one of resin acid, metallic soap and atoleine, the surfactant are neopelex, lecithin and rouge
Fat acid sorb is at least one of smooth；In step b), the intake air temperature of the spray drying is 170-250 DEG C；Air outlet temperature
Degree is 70-100 DEG C.
6. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease as described in claim 1, it is characterised in that: the Chinese medicine and cream
The mass percent of body matrix are as follows: Chinese medicine 19.5 ~ 20.2%, ointment bases 79.8 ~ 80.5%.
7. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease as claimed in claim 6, it is characterised in that: the ointment bases
Composition including following parts by weight: 39 ~ 46 parts of medical thermoplastic elastomer (TPE), 15 ~ 29 parts of medical tackifier, medical softening agent 20
~ 38 parts, 1 ~ 5 part of skin penetration enhancer, load have 4 ~ 7 parts of 7 ~ 10 parts of microballoon, filler zinc oxide, the far-infrared ceramic of aluminium powder
0.6 ~ 1 part of powder, 7 ~ 8 parts and 1 ~ 2 part of antioxidant of magnetic powder.
8. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease as claimed in claim 6, it is characterised in that: the Chinese medicine includes
Following components: 12-14 parts of Radix Angelicae Sinensis, 8-10 parts of Rhizoma Chuanxiong, 8-10 parts of leech, 8-10 parts of Eupolyphoge sinensis, 4-6 parts of radix paeoniae rubra, 4-6 parts of peach kernel, red
Flower 6-8 parts, 12-14 parts of pheretima, 7-9 parts of pueraria lobata, 18-20 parts of the root of Dahurain angelica, 10-12 parts of rhizoma acori graminei, 10-12 parts of Radix Polygalae, rhizoma typhonii 7-9
Part, 5-7 parts of arisaema cum bile, 5-8 parts of bombys batryticatus, wide 200-280 parts and 460-540 parts of vegetable oil of pellet.
9. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease as claimed in claim 7, it is characterised in that: the antioxidant is
Antioxidant BHT；The thermoplastic elastomer is styrenic thermoplastic elastomer, polyester-type thermoplastic rubber, thermoplastic polyurethane
At least one of；The tackifier are natural or synthetic resin, and the natural or synthetic resin is cyclopentadiene, isoamyl two
At least one of alkene, rosin, hydrogenated rosin, hydrogenated rosin glycerolipid；The softening agent is atoleine, lanolin, Huang
At least one of vaseline, vaseline；The skin penetration enhancer includes host agent and adjuvant, and the host agent is N- diformazan ammonia
At least one of base n-butyric acie dodecane ester and bisabolol, ferulic acid and glycerol monopentyl ether, the adjuvant are three pungent
At least one of methyl ammonium and bromo 1- butyl -3- methyl-imidazoles.
10. a kind of traditional Chinese medicine plaster of resisting cardiovascular disease as claimed in claim 8, it is characterised in that: the vegetable oil
For at least one of sesame oil, rapeseed oil, cotton oil.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925184A (en) * | 2019-03-28 | 2019-06-25 | 尹昭军 | A kind of nanometer of thermal sensation massage cream mud ontology, patch, cream and preparation method |
| CN112500839A (en) * | 2020-12-09 | 2021-03-16 | 泰兴瑞深新材科技有限公司 | Preparation method of self-heating express heat insulation material |
| CN113368081A (en) * | 2021-05-24 | 2021-09-10 | 杭州仁德医药有限公司 | A Chinese medicinal patch for treating cerebral thrombosis, and its preparation method |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077893A (en) * | 1992-04-28 | 1993-11-03 | 焦志军 | Preparation method of Dantian heart-strengthening plaster |
| CN1277018A (en) * | 2000-04-11 | 2000-12-20 | 上海伊健实业有限公司 | Far infrared plaster and its preparation |
| CN1491683A (en) * | 2002-10-21 | 2004-04-28 | 马德林 | Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris and its preparing method |
| CN101361975A (en) * | 2008-09-25 | 2009-02-11 | 桂林天和药业股份有限公司 | Medical plaster hot-melt adhesive ground substance, traditional Chinese medicine plaster using the ground substance and preparation method thereof |
| CN101912493A (en) * | 2010-08-19 | 2010-12-15 | 李文奇 | Acupoint plaster for treating cardiovascular and cerebrovascular diseases |
| CN102159257A (en) * | 2008-07-17 | 2011-08-17 | 米歇尔技术公司 | Drug delivery medical device |
| CN102596185A (en) * | 2009-07-29 | 2012-07-18 | 麦德托尼克公司 | An implantable drug depot having a reversible phase transition material for treatment of pain and/or inflammation |
| CN102634307A (en) * | 2012-05-03 | 2012-08-15 | 河南羚锐制药股份有限公司 | Hot-melting pressure sensitive adhesive and preparation method thereof |
| CN103705937A (en) * | 2014-01-09 | 2014-04-09 | 贵州康琦药械有限公司 | Medicinal plaster substrate, medicinal plaster using the substrate and preparation method thereof |
| CN206434472U (en) * | 2016-11-04 | 2017-08-25 | 云南白药集团股份有限公司 | It is a kind of can dosing hot compress paste |
| CN107456548A (en) * | 2017-08-17 | 2017-12-12 | 杭州仁德医药有限公司 | A kind of external plaster for zhuanggu of easing pain |
| CN108030871A (en) * | 2018-02-06 | 2018-05-15 | 重庆医科大学附属永川医院 | A kind of production method of senile hypertension decompression ointment |
| CN108066137A (en) * | 2017-12-08 | 2018-05-25 | 山东木齐健康科技有限公司 | Hydrogen molecule physical therapy plaster and application |
| CN108686217A (en) * | 2017-04-07 | 2018-10-23 | 成都夸常科技有限公司 | A kind of pharmaceutical composition and its application including drug and particulate carrier |
-
2018
- 2018-10-26 CN CN201811260275.3A patent/CN109464559A/en active Pending
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077893A (en) * | 1992-04-28 | 1993-11-03 | 焦志军 | Preparation method of Dantian heart-strengthening plaster |
| CN1277018A (en) * | 2000-04-11 | 2000-12-20 | 上海伊健实业有限公司 | Far infrared plaster and its preparation |
| CN1491683A (en) * | 2002-10-21 | 2004-04-28 | 马德林 | Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris and its preparing method |
| CN102159257A (en) * | 2008-07-17 | 2011-08-17 | 米歇尔技术公司 | Drug delivery medical device |
| CN101361975A (en) * | 2008-09-25 | 2009-02-11 | 桂林天和药业股份有限公司 | Medical plaster hot-melt adhesive ground substance, traditional Chinese medicine plaster using the ground substance and preparation method thereof |
| CN102596185A (en) * | 2009-07-29 | 2012-07-18 | 麦德托尼克公司 | An implantable drug depot having a reversible phase transition material for treatment of pain and/or inflammation |
| CN101912493A (en) * | 2010-08-19 | 2010-12-15 | 李文奇 | Acupoint plaster for treating cardiovascular and cerebrovascular diseases |
| CN102634307A (en) * | 2012-05-03 | 2012-08-15 | 河南羚锐制药股份有限公司 | Hot-melting pressure sensitive adhesive and preparation method thereof |
| CN103705937A (en) * | 2014-01-09 | 2014-04-09 | 贵州康琦药械有限公司 | Medicinal plaster substrate, medicinal plaster using the substrate and preparation method thereof |
| CN206434472U (en) * | 2016-11-04 | 2017-08-25 | 云南白药集团股份有限公司 | It is a kind of can dosing hot compress paste |
| CN108686217A (en) * | 2017-04-07 | 2018-10-23 | 成都夸常科技有限公司 | A kind of pharmaceutical composition and its application including drug and particulate carrier |
| CN107456548A (en) * | 2017-08-17 | 2017-12-12 | 杭州仁德医药有限公司 | A kind of external plaster for zhuanggu of easing pain |
| CN108066137A (en) * | 2017-12-08 | 2018-05-25 | 山东木齐健康科技有限公司 | Hydrogen molecule physical therapy plaster and application |
| CN108030871A (en) * | 2018-02-06 | 2018-05-15 | 重庆医科大学附属永川医院 | A kind of production method of senile hypertension decompression ointment |
Non-Patent Citations (3)
| Title |
|---|
| 傅杰，等: "聚合物药物控制释放体系研究进展", 《材料导报》 * |
| 朱传龙: "聚乳酸无纺布的制备及性能研究", 《湖北大学硕士学位论文》 * |
| 潘斌斌，等: "中药新剂型的研究进展", 《湖北中医杂志》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925184A (en) * | 2019-03-28 | 2019-06-25 | 尹昭军 | A kind of nanometer of thermal sensation massage cream mud ontology, patch, cream and preparation method |
| CN109925184B (en) * | 2019-03-28 | 2024-01-16 | 尹昭军 | Nanometer thermal massage paste body, plaster and preparation method |
| CN112500839A (en) * | 2020-12-09 | 2021-03-16 | 泰兴瑞深新材科技有限公司 | Preparation method of self-heating express heat insulation material |
| CN112500839B (en) * | 2020-12-09 | 2021-10-19 | 上海惠洲实业有限公司 | Preparation method of self-heating express heat insulation material |
| CN113368081A (en) * | 2021-05-24 | 2021-09-10 | 杭州仁德医药有限公司 | A Chinese medicinal patch for treating cerebral thrombosis, and its preparation method |
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Application publication date: 20190315 |