CN104623300A - Traditional Chinese medicine for preventing shiver after anesthesia and preparation method of traditional Chinese medicine - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for preventing shiver after anesthesia and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw materials: oyster mushroom, clove, monkshood, diaphragma juglandis, orobanche coerulescens, angelica gigas, tubeflower viburnum herb, denseflower bulbophyllum herb, polygonum oriental root, hypericum patulum, blumea lanceolaria, root of rosthorn bigginseng, wilson's passion flower, curious kadsura root stem, divaricate saposhnikovia root, Japanese pachysamdra herb, flabelate maiden-hair herb and red agaric. The traditional Chinese medicine has the beneficial effects of being free of toxic or side effect and high in effective rate by using the theory of the traditional Chinese medicine in China, and is capable of effectively reducing the shiver phenomenon after anesthesia.

Description

A kind ofly prevent Chinese medicine of anaesthetizing rear shiver with cold and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, particularly relate to and a kind ofly prevent Chinese medicine of anaesthetizing rear shiver with cold and preparation method thereof.

Background technology

Anesthesia is the mark of modern medical service progress, various anesthesia no doubt makes sufferer carry out surgical operation under calm, painless comfort conditions, but anaesthetic is except impact consciousness, change Pain Cognition degree, also the normal physiological function of sufferer can be disturbed, such as heart beating, blood pressure, breathing etc.

Shiver with cold after anesthesia, first show as peripheral blood vessel and shrink and central body temperature decline, be i.e. so-called " shivering with cold after idiopathic general anesthesia ", " penthiobarbital sample is tetanic ", its incidence rate is usually 5% ~ 65%.The hazardness of shiver with cold: 1, organism metabolism rate significantly raises, body oxygen consumption increases, and oxygen consumption is for common 2 ~ 5 times, carbon dioxide and lactic acid generate and increase simultaneously, body is breathed by reinforcement and cardiac work obtains compensatory, and therefore cardiopulmonary load increases, and can cause cardiorespiratory failure to critical patient.2, ambulatory electrocardiogram confirms, body temperature is lower than the patient of 35 DEG C, and the ratio of myocardial ischemia is apparently higher than the normal patient of body temperature.3, shiver with cold under low temperature, platelet function can be damaged, coagulation cascade response inhabitation, and blood loss significantly increases, and transfusion volume increases.

After anesthesia, the mechanism of shiver with cold is not yet completely clear.Sessler research is thought: the distribution of human heat can be divided into " central compartment " and " peripheral compartment ".Central compartment's blood flow enriches, and its temperature claims " core temperature ", and maintenance is stabilized in a very narrow scope.Peripheral compartment's temperature is comparatively large by the impact of ambient temperature, also there is larger temperature contrast between the various piece of peripheral compartment.Heat between central compartment and peripheral compartment is among dynamic change.Under normal circumstances, time cold, peripheral blood vessel shrinks, and the heat watershed between central compartment and peripheral compartment is few, thus minimizing intimate heat scatters and disappears, to keep the stable of central compartment's temperature.Under narcotism, due to sympathetic nerve function retardance, the contractile response of peripheral blood vessel to cold stimulation weakens.Like this, body heat conducts (heat distributes again) to peripheral compartment fast by central compartment, and central temperature declines rapidly, thus stimulates organism temperature sensor and cause chill reaction.Core temperature declines in first hour and reaches 0.8 ± 0.3 DEG C after induction of anesthesia; The redistribution of body heat accounts for 89%.In 3h subsequently, body temperature continues to decline about 0.4 ± 0.3 DEG C, and wherein the distribution again of body heat accounts for 62%.Visible, in anaesthesia process, the distribution again of body heat is the key factor causing shiver with cold.If reduce distributing again of body heat in anesthesia, shiver with cold generation will reduce.Rosenberg etc. think, after anesthesia, shiver with cold is that rear nerve centre at different levels recovers the speed of awakening with anesthesia, and sequencing difference is relevant, and spinal cord RC is more Zao than the awakening of brain response maincenter, thus cause spontaneous muscle tremors, be the result of not autonomic reflex.Separately someone thinks, shiver with cold is because of in patient's anesthesia recovery process, brain thermotaxic centre dysfunction and occurring.

The inducement of shiver with cold after anaesthetizing is a lot, can't affirm that any is the definite factor of bringing out shiver with cold at present, but various inducement all rear certain dependencys of shivering with cold with anesthesia.

1, the inducement of low temperature: low temperature can cause shiver with cold, coldly stimulates shell temperature receptor and intracranial temperature neuron, acts on hypothalamus thermotaxic centre simultaneously, impels that muscular tremor, cardiopulmonary activity strengthen, heat production, uses thermal balance in holder.The reason of patient's shiver with cold under Ponte proposition epidural anesthesia in 1986, relevant with the stimulation that spinal cord temperature receptor is subject to cold anesthetics.Nishimura etc. show, Balance anesthesia shiver with cold is lowered relevant with periphery shell temperature.Current research shows, the temperature of local anaesthetics itself, is not the reason causing shiver with cold, and epidural drip low-temperature normal saline (17 ± 2.2 DEG C) can't cause shiver with cold.The difference of above-mentioned result of study is very large, but generally believes: peri-operation period, to body insulation, prevention low temperature, can be avoided shiver with cold, or suppress shiver with cold.Input control and adjustment thermal information, can affect the generation of shiver with cold, may lower with Anesthesia recovery stage brain centres to the reaction of cold, and spinal center reaction is normally relevant.

2, pyrogen factor: blood transfusion and infusion process in art, can sudden chill, Gao Reda 38 ~ 41 DEG C, and the symptoms such as companion feels sick, headache, rapid pulse, be the pyrogen reaction that blood transfusion and infusion causes, the latter can make thermotaxic centre unbalance.

3, Patient factor: Nishimura etc. show, after younger patient anesthesia, the sickness rate of shiver with cold is higher than elderly patients, and with the protection mechanism of younger patient body to low grade fever, improving than elderly patients may be relevant.Crossley observes 2595 routine observation ward patients, finds that the shiver with cold incidence rate of male patient is significantly higher than female patients; Between twenty and fifty patient is higher than children's and elderly patients.Generation and patient's height of shiver with cold, body weight is without obvious relation.

4, medicine factor: Crossley finds, preoperative use anticholinergic agent, can reduce shiver with cold.Alfentanil is applied and Pethidine can reduce shiver with cold in art.Apply volatile anesthetic person in art easily to shiver with cold.Goold reports, preoperative application analgesic, and shiver with cold incidence rate is higher than without analgesic person; Preoperatively give the patient of tranquilizer, shiver with cold rate is lower than not user.

5, anoxia: have many factors to cause hypoxemia in art, the latter can cause Hypoxic shiver with cold, and companioned with headache, pulse frequency speed, hyperpnea, blood pressure rise, PaO2 declines.Time serious, decreased heart rate, respiration inhibition, unconsciousness, even faint from fear.

The prevention of the rear shiver with cold of anesthesia: first note peri-operation period insulation, utilizes insulation blanket, improves operating room environment temperature, anesthetic stage heats and humidifying suction gas, can reduce tracheal strips heat radiation.Spread list as early as possible after operation sterilizing is complete, reduce patient temperature and decline, shiver with cold can be prevented.The key elements such as preoperative application Dopram, clonidine, or preoperatively give stable grade for tranquilizer, shiver with cold after anesthesia can be reduced.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of pure Chinese medicinal preparation, Chinese medicine of shiver with cold after the prevention anesthesia having no side effect high with effective percentage and preparation method thereof.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preventing to anaesthetize rear shiver with cold, its raw medicinal material comprises: pick up the ears, Flos Caryophylli, Radix Aconiti Lateralis Preparata, Partition in Fructus Juglandis, Herba Orobanches, Angelica gig, Folium Viburni Cylindrici, Herba Bulbophylli Odoratissim, Herba Polygoni Orientalis root, Herba Hyperici Patuli, Herba Blumeae lanceolariae, Radix Macropanacis Rosthornii, Herba Passiflorae Wilsonii, Radix seu Caulis Kadsurae Heteroclitae, Radix Saposhnikoviae, grass green for a long time, Herba Adianti Flabellulati and Herba Iresines Herbstii.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: pick up the ears 20 ~ 30 parts, Flos Caryophylli 10 ~ 20 parts, Radix Aconiti Lateralis Preparata 5 ~ 15 parts, Partition in Fructus Juglandis 10 ~ 20 parts, Herba Orobanches 5 ~ 15 parts, Angelica gig 15 ~ 25 parts, Folium Viburni Cylindrici 10 ~ 20 parts, Herba Bulbophylli Odoratissim 5 ~ 15 parts, Herba Polygoni Orientalis root 10 ~ 20 parts, Herba Hyperici Patuli 30 ~ 40 parts, Herba Blumeae lanceolariae 20 ~ 30 parts, Radix Macropanacis Rosthornii 10 ~ 20 parts, Herba Passiflorae Wilsonii 5 ~ 15 parts, Radix seu Caulis Kadsurae Heteroclitae 15 ~ 25 parts, Radix Saposhnikoviae 10 ~ 20 parts, 5 ~ 15 parts green for a long time, Herba Adianti Flabellulati 20 ~ 30 parts and Herba Iresines Herbstii 15 ~ 25 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: pick up the ears 25 ~ 30 parts, Flos Caryophylli 15 ~ 20 parts, Radix Aconiti Lateralis Preparata 5 ~ 10 parts, Partition in Fructus Juglandis 10 ~ 15 parts, Herba Orobanches 5 ~ 10 parts, Angelica gig 20 ~ 25 parts, Folium Viburni Cylindrici 15 ~ 20 parts, Herba Bulbophylli Odoratissim 5 ~ 8 parts, Herba Polygoni Orientalis root 10 ~ 15 parts, Herba Hyperici Patuli 35 ~ 40 parts, Herba Blumeae lanceolariae 25 ~ 30 parts, Radix Macropanacis Rosthornii 10 ~ 15 parts, Herba Passiflorae Wilsonii 5 ~ 10 parts, Radix seu Caulis Kadsurae Heteroclitae 20 ~ 25 parts, Radix Saposhnikoviae 15 ~ 20 parts, 10 ~ 15 parts green for a long time, Herba Adianti Flabellulati 25 ~ 30 parts and Herba Iresines Herbstii 20 ~ 25 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: pick up the ears 28 parts, Flos Caryophylli 20 parts, Radix Aconiti Lateralis Preparata 8 parts, Partition in Fructus Juglandis 15 parts, Herba Orobanches 10 parts, Angelica gig 25 parts, Folium Viburni Cylindrici 20 parts, Herba Bulbophylli Odoratissim 8 parts, Herba Polygoni Orientalis root 11 parts, Herba Hyperici Patuli 40 parts, Herba Blumeae lanceolariae 30 parts, Radix Macropanacis Rosthornii 15 parts, Herba Passiflorae Wilsonii 10 parts, Radix seu Caulis Kadsurae Heteroclitae 25 parts, Radix Saposhnikoviae 20 parts, 15 parts green for a long time, Herba Adianti Flabellulati 30 parts and Herba Iresines Herbstii 25 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: pick up the ears 25 parts, Flos Caryophylli 18 parts, Radix Aconiti Lateralis Preparata 5 parts, Partition in Fructus Juglandis 14 parts, Herba Orobanches 8 parts, Angelica gig 23 parts, Folium Viburni Cylindrici 18 parts, Herba Bulbophylli Odoratissim 6 parts, Herba Polygoni Orientalis root 13 parts, Herba Hyperici Patuli 38 parts, Herba Blumeae lanceolariae 28 parts, Radix Macropanacis Rosthornii 13 parts, Herba Passiflorae Wilsonii 8 parts, Radix seu Caulis Kadsurae Heteroclitae 24 parts, Radix Saposhnikoviae 18 parts, 12 parts green for a long time, Herba Adianti Flabellulati 26 parts and Herba Iresines Herbstii 22 parts.

Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps,

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described Chinese medicine is injectable powder, its preparation method comprises the following steps,

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Beneficial effect of the present invention: Chinese medicine provided by the invention, utilizes the theory of Chinese medical science that China is traditional, has and have no side effect, the advantage that effective percentage is high, occurs shiver with cold phenomenon after effectively can reducing anesthesia.

Detailed description of the invention

The invention provides a kind of Chinese medicine preventing to anaesthetize rear shiver with cold, its raw medicinal material comprises: pick up the ears, Flos Caryophylli, Radix Aconiti Lateralis Preparata, Partition in Fructus Juglandis, Herba Orobanches, Angelica gig, Folium Viburni Cylindrici, Herba Bulbophylli Odoratissim, Herba Polygoni Orientalis root, Herba Hyperici Patuli, Herba Blumeae lanceolariae, Radix Macropanacis Rosthornii, Herba Passiflorae Wilsonii, Radix seu Caulis Kadsurae Heteroclitae, Radix Saposhnikoviae, grass green for a long time, Herba Adianti Flabellulati and Herba Iresines Herbstii.

The herbal pharmacology of each raw medicinal material is as follows:

Pick up the ears: [another name] Fungus Pleurotus ostreatus, oyster bacterium, assorted mushroom.This product is that Mycophyta Basidiomycetes Agaricales Agaricaceae is picked up the ears Pleurotus ostreatus (Jacq.ex Fr.) Quel., is used as medicine with sporophore.Micro-salty, temperature.Chase after wind, cold expelling, relaxing muscles and tendons, active.[extracts] " national Chinese herbal medicine compilation "

Flos Caryophylli: [another name] Flos Caryophylli [alabastrum], Fructus Caryophylli [fruit].For Myrtaceae Eugenia plant of clove Eugenia caryophyllata Thunb. [E.aromatica Baill.; Syzygium aromatica (L) Merr.et Perry], with alabastrum and its fruit medicine.Start in white at alabastrum, virescence gradually, can gather time finally in cerise.The alabastrum adopted removing bennet is dried.Pungent, temperature.Warming the spleen stomach, lowering the adverse flow of QI.Cure mainly cold syndrome of the stomach vomiting, vomit and diarrhoea, gastral cavity abdomen is had a pain.[extracts] " national Chinese herbal medicine compilation "

Radix Aconiti Lateralis Preparata: [another name] Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata.This product is the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..Late June excavated to early August, and removing parent root, fibrous root and silt, practise and claim " mud Radix Aconiti Lateralis Preparata ", be processed into following kinds.Pungent, sweet, hot greatly; Poisonous.GUIXIN, kidney, spleen channel.Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by wind-cold damp pathogen.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.[extracts] " Chinese Pharmacopoeia "

Partition in Fructus Juglandis: [another name] Semen Juglandis kind every.This product is the wooden barrier film of juglandaceae plant Semen Juglandis Juglans regia L..Bitter, puckery, flat.The kidney invigorating arresting seminal emission.For emission due to deficiency of the kidney, spermatorrhea, the enuresis.[extracts] " national Chinese herbal medicine compilation "

Herba Orobanches: [another name] Herba Boschniakiae Rossicae, Du Gencao, rabbit bent stick.For Orobanchaceae Orobanche plant Herba Orobanches Orobanche caerulescens Steph., with all herbal medicine.Early summer is gathered, and solarization eighty per cant is dry, is bundled into wisp, then dries.Sweet, temperature.Reinforcing the kidney and supporting YANG, bone and muscle strengthening.For sexual neurasthenie, lassitude loin and legs; Infantile diarrhea is controlled in external, enteritis, dysentery.[extracts] " national Chinese herbal medicine compilation "

Angelica gig: [another name] Radix Angelicae Gigatis.For the root of samphire Angelica gig.Acrid in the mouth; Warm in nature.Dispelling wind and removing obstruction in the collateral; Promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Folium Viburni Cylindrici: [another name] powder handkerchief leaf (" Kunming conventional medical herbs among the people "), powder Folium paulowniae (" choosing of Simao, Yunnan Chinese herbal medicine ").For Radix Ophiopogonis Piao's vegetation water redwood leaf or root, flower.The whole year can adopt." choosing of Simao, Yunnan Chinese herbal medicine ": " cool in nature, lightly seasoned puckery." clearing away heat and cooling blood, removing dampness dredging collateral.Control cough caused by dryness, dysentery, rheumatalgia, traumatic injury, skin infection scabies.[extracts] " Chinese medicine voluminous dictionary "

Herba Bulbophylli Odoratissim: [another name] Bulbophyllum odoratissimum Lindl., Bulbophyllum calodictyon schlecht., elaeagnus conferta fruits.The orchid family Bulbophyllum platymiscium extremely fragrant Bulbophyllum Bulbophyllum odoratissimum (Swartz) Lindl., with all herbal medicine.The four seasons can adopt, and clean, using fresh herb or dry.Sweet, light, flat.Moistening the lung and resolving phlegm, relaxing muscles and tendons and activating QI and blood in the collateral, antiinflammatory.For hemoptysis of pulmonary tuberculosis, chronic tracheitis, chronic pharyngitis, rheumatism bones and muscles pain; Fracture is controlled in external, and traumatic injury is dampened, knife injury.[extracts] " national Chinese herbal medicine compilation "

Herba Polygoni Orientalis root: [another name] Herba Polygoni Orientalis root, smartweed root.For the rhizome of polygonaceae plant Polygonum knotweed.Pungent; Cool in nature; Poisonous.Heat-clearing and toxic substances removing; Eliminating dampness and dredging channels; Promoting tissue regeneration and ulcer healing.Main dysentery; Intestinal is scorching; Edema; Foot gas; Rheumatic arthralgia; Traumatic injury; Urticaria; Sore, carbuncle and painful swelling or of a specified duration bursting are not held back.[extracts] " China's book on Chinese herbal medicine "

Herba Hyperici Patuli: [another name] Radix Hyperici Monogyni (Herba Hyperici Monogyni), pig thumb willow, Fructus Hyperici belli, Herba Hyperici Patuli, Hypericum beanii, SHANZHIZI, Hubei anemone, Lysimachia christinae Hance, great Ye Huang, limit, land for growing field crops Huang, Cladrastis kentukea Rudd, Jin Xiang, Dragon Boat Festival flower.For the Herb of Garcinia maingayii Herba Hyperici Patuli.Bitter; Cold.Liver; Kidney; Urinary bladder channel.Clearing away heat-damp and promoting diuresis detoxifies; Dispersing the stagnated liver-QI and dredging collateral; Stasis-dispelling and pain-killing.Main damp and hot gonorrhea; Hepatitis; Flu; Tonsillitis; The hernia swelling and hanging down of either of the testes; Bones and muscles pain; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba Blumeae lanceolariae: [another name] Herba Blumeae Laciniatae.For the leaf of feverfew thousand Herba Blumeae Balsamiferaes.Acrid in the mouth; Property is put down.Expelling wind and activating blood circulation; Removing obstruction in the collateral to relieve pain.Main head's wind pain; Rheumatic arthralgia; Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix Macropanacis Rosthornii: [another name] Cortex torricelliae tiliifoliae.For root, leaf that the short stalk of Araliaceae is joined greatly.The whole year can adopt.Property is put down, sweet in the mouth.Evil-wind expelling and dampness removing, blood stasis dispersing and fresh blood promoting.Control fracture, rheumatic ostalgia.[extracts] " Chinese medicine voluminous dictionary "

Herba Passiflorae Wilsonii: [another name] slice leaf, Oxyria sinensis Hemsl. (" choosing of Yunnan Chinese herbal medicine "), half-section leaf, half-section kwan-yin (" choosing of Simao, Yunnan Chinese herbal medicine "), tooth is muttered dam (Dai Nationality's name).For the herb of Passifloraceae plant Passiflora wilsonii.The whole year can adopt.Dry.Micro-hardship, temperature.Relaxing muscles and tendons to promote blood circulation, removing dampness and killing parasites.Treating rheumatic arthritis, injury and bone fracture, hepatitis.Malaria, ascariasis.[extracts] " Chinese medicine voluminous dictionary "

Radix seu Caulis Kadsurae Heteroclitae: [another name] large rice dumpling, box bit drill, Radix seu Caulis fici Martinii (" Guangxi Chinese herbal medicine "), Caulis Seu Radix Kadsurae Oblongifoliae, large FENGSHATENG, large Radix Morindae Officinalis, Kadsura coccinea (Lem.) A.C. Smith, silk ball are fragrant, Radix seu Caulis Kadsurae Heteroclitae (" choosing of Simao, Yunnan Chinese herbal medicine ").For root or the ratan of Magnoliacea plant Kadsura heteroclita.The whole year can adopt, and section is dried." choosing of Simao, Yunnan Chinese herbal medicine ": " micro-cover with mat pungent, temperature." expelling wind and removing dampness, promoting flow of QI and blood.Dispelling the wind and dampness pathogens arthralgia pain, gastric and duodenal ulcers, acute/chronic gastroenteritis, dysmenorrhea, puerperal abdonimal pain, traumatic injury.[extracts] " Chinese medicine voluminous dictionary "

Radix Saposhnikoviae: [another name] copper rues (" herbal classic "), fennel rues, fennel grass, Rhizoma Cibotii, gate of a village root, hundred roaches (" WU Pu Bencao "), screen (" not Lu "), wind meat (" medical material compilation of data ").For the root of umbelliferae Saposhnikovia divaricata.Spring, Qiu Junke excavate, and after being dug out by root, removing stem and leaf and earth, first shines to eighty per cant dry, bundle after, then shine to foot dry.Xin Gan, temperature.Enter bladder, lung, spleen channel.Deliver, dispel the wind, victory is wet, pain relieving.Control affection of exogenous wind-cold, headache, dizzy, stiffness of the nape, anemofrigid-damp arthralgia, joint is ached, and extremity contraction is anxious, tetanus.[extracts] " Chinese medicine voluminous dictionary "

Grass green for a long time: [another name] snow mountain Siberian cocklebur, the celestial rope of bundle, Pachysandra terminalis, Pachysandra terminalis, Radix Cynanchi Paniculati, native Radix Platycodonis, Ilex purpurea Hassk.[I.chinensis Sims [Sichuan].Buxaceae powder stamen Buxus plant top stamen Herba Pachysandrae Stylosae Pachysandra terminalis Sieb.et Zucc., with all herbal medicine.The whole year can adopt, and cleans cutting, dries.Bitter, micro-pungent, flat.Dispelling wind stopping cough, relaxing muscles and tendons and activating QI and blood in the collateral, adjusting meridian and stopping leukorrhea.For chronic tracheitis, rheumatic arthritis, spasm of the calf, leucorrhea, amenorrhea, psychosis dysphoria.[extracts] " national Chinese herbal medicine compilation "

Herba Adianti Flabellulati: [another name] Herba cynodontis, black bone awns, seedling occupies grass (" south of the Five Ridges gather medicinal herbs record "), venushair fern, black bone awn winnow basket (" Guangzhou flora "), spiral shell is fainted Herba pteridii latiusculi, black foot Herba pteridii latiusculi, the black Herba pteridii latiusculi of five pawls (" figure will planted by Guangxi medicine "), crow foot rifle (" Luchuan book on Chinese herbal medicine "), spiral shell dimple Herba pteridii latiusculi (" Nanning City's medicine will "), Tie Jiao road dustpan (" Jiangxi traditional herbal medicine "), Tieluji, the crow fly wing, little Fel Ursi (" south of the Five Ridges herbal "), JIZHUALIAN (" Hunan medicine will "), crow foot roadbed, ferrum bamboo strainer (" Jiangxi traditional herbal medicine proved recipe "), ferrum foot wolf beanstalk, two first grass, Herba Abri, crow foot chicken, five pawl Herba pteridii latiusculis, ferrum wolf beanstalk (" Zhejiang conventional medical herbs among the people ").For herb or the rhizome of adiantaceae plant flabellum venushair fern.The whole year can adopt, using fresh herb or dry.Toil, cool.Heat clearing away, dampness removing, repercussive, loose swollen.Control acute infectious hepatitis, dysentery, diarrhoea, sand Stranguria, spit blood, have blood in stool, scrofula, traumatic injury, scald, traumatic hemorrhage, furuncle.[extracts] " Chinese medicine voluminous dictionary "

Herba Iresines Herbstii: [another name] red indigo, Ilex pedunculosa Miq (" mountain of papers Chinese herbal medicine ").For the herb of amaranthaceous plant Iresine herbetii.Bitter micro-sweet, cool.Removing heat from blood, hemostasis.Control haematemesis, epistaxis, hemoptysis, wound hemorrhage, dysentery, dysmenorrhea." mountain of papers Chinese herbal medicine ": " relaxing muscles and tendons to promote blood circulation, menstruction regulating and pain relieving.Control menoxenia, epistaxis, dysmenorrhea, fracture." [extracts] " Chinese medicine voluminous dictionary "

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: pick up the ears 20 ~ 30 parts, Flos Caryophylli 10 ~ 20 parts, Radix Aconiti Lateralis Preparata 5 ~ 15 parts, Partition in Fructus Juglandis 10 ~ 20 parts, Herba Orobanches 5 ~ 15 parts, Angelica gig 15 ~ 25 parts, Folium Viburni Cylindrici 10 ~ 20 parts, Herba Bulbophylli Odoratissim 5 ~ 15 parts, Herba Polygoni Orientalis root 10 ~ 20 parts, Herba Hyperici Patuli 30 ~ 40 parts, Herba Blumeae lanceolariae 20 ~ 30 parts, Radix Macropanacis Rosthornii 10 ~ 20 parts, Herba Passiflorae Wilsonii 5 ~ 15 parts, Radix seu Caulis Kadsurae Heteroclitae 15 ~ 25 parts, Radix Saposhnikoviae 10 ~ 20 parts, 5 ~ 15 parts green for a long time, Herba Adianti Flabellulati 20 ~ 30 parts and Herba Iresines Herbstii 15 ~ 25 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: pick up the ears 25 ~ 30 parts, Flos Caryophylli 15 ~ 20 parts, Radix Aconiti Lateralis Preparata 5 ~ 10 parts, Partition in Fructus Juglandis 10 ~ 15 parts, Herba Orobanches 5 ~ 10 parts, Angelica gig 20 ~ 25 parts, Folium Viburni Cylindrici 15 ~ 20 parts, Herba Bulbophylli Odoratissim 5 ~ 8 parts, Herba Polygoni Orientalis root 10 ~ 15 parts, Herba Hyperici Patuli 35 ~ 40 parts, Herba Blumeae lanceolariae 25 ~ 30 parts, Radix Macropanacis Rosthornii 10 ~ 15 parts, Herba Passiflorae Wilsonii 5 ~ 10 parts, Radix seu Caulis Kadsurae Heteroclitae 20 ~ 25 parts, Radix Saposhnikoviae 15 ~ 20 parts, 10 ~ 15 parts green for a long time, Herba Adianti Flabellulati 25 ~ 30 parts and Herba Iresines Herbstii 20 ~ 25 parts

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: pick up the ears 28 parts, Flos Caryophylli 20 parts, Radix Aconiti Lateralis Preparata 8 parts, Partition in Fructus Juglandis 15 parts, Herba Orobanches 10 parts, Angelica gig 25 parts, Folium Viburni Cylindrici 20 parts, Herba Bulbophylli Odoratissim 8 parts, Herba Polygoni Orientalis root 11 parts, Herba Hyperici Patuli 40 parts, Herba Blumeae lanceolariae 30 parts, Radix Macropanacis Rosthornii 15 parts, Herba Passiflorae Wilsonii 10 parts, Radix seu Caulis Kadsurae Heteroclitae 25 parts, Radix Saposhnikoviae 20 parts, 15 parts green for a long time, Herba Adianti Flabellulati 30 parts and Herba Iresines Herbstii 25 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: pick up the ears 25 parts, Flos Caryophylli 18 parts, Radix Aconiti Lateralis Preparata 5 parts, Partition in Fructus Juglandis 14 parts, Herba Orobanches 8 parts, Angelica gig 23 parts, Folium Viburni Cylindrici 18 parts, Herba Bulbophylli Odoratissim 6 parts, Herba Polygoni Orientalis root 13 parts, Herba Hyperici Patuli 38 parts, Herba Blumeae lanceolariae 28 parts, Radix Macropanacis Rosthornii 13 parts, Herba Passiflorae Wilsonii 8 parts, Radix seu Caulis Kadsurae Heteroclitae 24 parts, Radix Saposhnikoviae 18 parts, 12 parts green for a long time, Herba Adianti Flabellulati 26 parts and Herba Iresines Herbstii 22 parts.

Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described Chinese medicine is injectable powder, its preparation method comprises the following steps,

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: tablet prepared by the present invention

Get the 280g that picks up the ears, Flos Caryophylli 200g, Radix Aconiti Lateralis Preparata 80g, Partition in Fructus Juglandis 150g, Herba Orobanches 100g, Angelica gig 250g, Folium Viburni Cylindrici 200g, Herba Bulbophylli Odoratissim 80g, Herba Polygoni Orientalis root 110g, Herba Hyperici Patuli 400g, Herba Blumeae lanceolariae 300g, Radix Macropanacis Rosthornii 150g, Herba Passiflorae Wilsonii 100g, Radix seu Caulis Kadsurae Heteroclitae 250g, Radix Saposhnikoviae 200g, 150g green for a long time, Herba Adianti Flabellulati 300g and Herba Iresines Herbstii 250g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 2.5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2.5 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.15 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.02 times of magnesium stearate, granulate, tabletting, makes.

Injectable powder prepared by embodiment 2 the present invention

Get the 250g that picks up the ears, Flos Caryophylli 180g, Radix Aconiti Lateralis Preparata 50g, Partition in Fructus Juglandis 140g, Herba Orobanches 80g, Angelica gig 230g, Folium Viburni Cylindrici 180g, Herba Bulbophylli Odoratissim 60g, Herba Polygoni Orientalis root 130g, Herba Hyperici Patuli 380g, Herba Blumeae lanceolariae 280g, Radix Macropanacis Rosthornii 130g, Herba Passiflorae Wilsonii 80g, Radix seu Caulis Kadsurae Heteroclitae 240g, Radix Saposhnikoviae 180g, 120g green for a long time, Herba Adianti Flabellulati 260g and Herba Iresines Herbstii 220g.

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.5 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 32 hours under the condition of 8 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 0.5 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.2g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Toxicity test:

Acute toxicity testing: application mice 80, male and female half and half, body weight 22 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 6.78g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 33.9 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>33.9 crude drug/kg, every day, maximum dosage-feeding was 67.8 crude drugs/kg/ day.Chinese medicine preparation clinical application amount of the present invention be 6.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.103g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 26g) oral administration gavage Chinese medicine preparation of the present invention is 658 times of quantity.Therefore Chinese medicine preparation acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine preparation embodiment 1 tablet of the present invention presses 11.87,21.13 and 36.88g crude drug/kg continuous use 14 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 14 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical experiment:

Case selection: get the 126 routine patient with operation that in August, 2013 ~ in November, 2014 derives from the court, and in preoperative 3 days, do not use Dopram, clonidine, the beautiful medicine asking pyrimidine, ondansetron etc. can prevent or treat shiver with cold of dextrorotation.Wherein, patients with general anesthesia 66 example, local anaesthesia patient 60 example.Wherein, tumor resection patient 54 example, bone injury patient 20 example, Appendicitis Patients 15 example, mammary gland fibroadenoma 13 example, Patients with Cholelithiasis 10 example, tooth pulling surgery patient 5 example, Patients undergoing Laparoscopic 9 example.Male 65 example, women 61 example, 16 ~ 65 years old age.

Be divided into treatment group and matched group at random, treatment group 63 example: wherein, patients with general anesthesia 34 example, local anaesthesia patient 29 example.Wherein, tumor resection patient 28 example, bone injury patient 10 example, Appendicitis Patients 7 example, mammary gland fibroadenoma 6 example, Patients with Cholelithiasis 5 example, tooth pulling surgery patient 2 example, Patients undergoing Laparoscopic 5 example.Male 33 example, women 30 example, 19 ~ 65 years old age.

Matched group 63 example: wherein, patients with general anesthesia 32 example, local anaesthesia patient 31 example.Wherein, tumor resection patient 26 example, bone injury patient 10 example, Appendicitis Patients 8 example, mammary gland fibroadenoma 7 example, Patients with Cholelithiasis 5 example, tooth pulling surgery patient 3 example, Patients undergoing Laparoscopic 4 example.Male 32 example, women 31 example, 16 ~ 63 years old age.

Two groups of patients compare on sex, age, the state of an illness, anesthesia method, and no significant difference, has comparability.

Prevention method:

Treatment group: the preoperative tablet taking the embodiment of the present invention 1 for 2 days, every day 3 times, each 3.

Matched group: preoperative 30 minutes according to 1mg/kg intravenous injection Dopram.

The standard of curative effect evaluation: effective: in art or postoperative patient without fear of cold or shiver with cold phenomenon; Effective: in art or postoperative patient have fear of cold, but do not occur shiver with cold; Invalid: in art or postoperative patient have fear of cold and shiver with cold phenomenon.

Therapeutic outcome: a situation arises the statistical result of two groups of Shiver after Epidural Analgesia in Patients Undergoings is in table 1, and as shown in Table 1, compared with matched group, medicine of the present invention obviously can reduce the generation of shiver with cold after anesthesia.

A situation arises that statistics is as follows for a table 1 liang group Shiver after Epidural Analgesia in Patients Undergoing: (example)

	n	Effective	Effectively	Invalid	Effectively total
						Treatment group	63	43(68.3％)	18(28.6％)	2(3.2％)	61(96.8％)
Matched group	63	32(50.8％)	21(33.3％)	10(15.9％)	53(84.1％)

After table 2 liang group corrective surgery, recovery room complication situation statistics is as follows: example

Known by table 2, matched group and treatment group basic zero difference in recovery room complication.

Untoward reaction: in Post operation 3 days, matched group and treatment group be occur obviously with medicine related reactions, and all there is not exception in the inspection such as the blood of two groups of patients, urine, stool routine and hepatic and renal function.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. one kind is prevented the Chinese medicine of anaesthetizing rear shiver with cold, it is characterized in that, its raw medicinal material comprises: pick up the ears, Flos Caryophylli, Radix Aconiti Lateralis Preparata, Partition in Fructus Juglandis, Herba Orobanches, Angelica gig, Folium Viburni Cylindrici, Herba Bulbophylli Odoratissim, Herba Polygoni Orientalis root, Herba Hyperici Patuli, Herba Blumeae lanceolariae, Radix Macropanacis Rosthornii, Herba Passiflorae Wilsonii, Radix seu Caulis Kadsurae Heteroclitae, Radix Saposhnikoviae, grass green for a long time, Herba Adianti Flabellulati and Herba Iresines Herbstii.

2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: pick up the ears 20 ~ 30 parts, Flos Caryophylli 10 ~ 20 parts, Radix Aconiti Lateralis Preparata 5 ~ 15 parts, Partition in Fructus Juglandis 10 ~ 20 parts, Herba Orobanches 5 ~ 15 parts, Angelica gig 15 ~ 25 parts, Folium Viburni Cylindrici 10 ~ 20 parts, Herba Bulbophylli Odoratissim 5 ~ 15 parts, Herba Polygoni Orientalis root 10 ~ 20 parts, Herba Hyperici Patuli 30 ~ 40 parts, Herba Blumeae lanceolariae 20 ~ 30 parts, Radix Macropanacis Rosthornii 10 ~ 20 parts, Herba Passiflorae Wilsonii 5 ~ 15 parts, Radix seu Caulis Kadsurae Heteroclitae 15 ~ 25 parts, Radix Saposhnikoviae 10 ~ 20 parts, 5 ~ 15 parts green for a long time, Herba Adianti Flabellulati 20 ~ 30 parts and Herba Iresines Herbstii 15 ~ 25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: pick up the ears 25 ~ 30 parts, Flos Caryophylli 15 ~ 20 parts, Radix Aconiti Lateralis Preparata 5 ~ 10 parts, Partition in Fructus Juglandis 10 ~ 15 parts, Herba Orobanches 5 ~ 10 parts, Angelica gig 20 ~ 25 parts, Folium Viburni Cylindrici 15 ~ 20 parts, Herba Bulbophylli Odoratissim 5 ~ 8 parts, Herba Polygoni Orientalis root 10 ~ 15 parts, Herba Hyperici Patuli 35 ~ 40 parts, Herba Blumeae lanceolariae 25 ~ 30 parts, Radix Macropanacis Rosthornii 10 ~ 15 parts, Herba Passiflorae Wilsonii 5 ~ 10 parts, Radix seu Caulis Kadsurae Heteroclitae 20 ~ 25 parts, Radix Saposhnikoviae 15 ~ 20 parts, 10 ~ 15 parts green for a long time, Herba Adianti Flabellulati 25 ~ 30 parts and Herba Iresines Herbstii 20 ~ 25 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: pick up the ears 28 parts, Flos Caryophylli 20 parts, Radix Aconiti Lateralis Preparata 8 parts, Partition in Fructus Juglandis 15 parts, Herba Orobanches 10 parts, Angelica gig 25 parts, Folium Viburni Cylindrici 20 parts, Herba Bulbophylli Odoratissim 8 parts, Herba Polygoni Orientalis root 11 parts, Herba Hyperici Patuli 40 parts, Herba Blumeae lanceolariae 30 parts, Radix Macropanacis Rosthornii 15 parts, Herba Passiflorae Wilsonii 10 parts, Radix seu Caulis Kadsurae Heteroclitae 25 parts, Radix Saposhnikoviae 20 parts, 15 parts green for a long time, Herba Adianti Flabellulati 30 parts and Herba Iresines Herbstii 25 parts.

5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: pick up the ears 25 parts, Flos Caryophylli 18 parts, Radix Aconiti Lateralis Preparata 5 parts, Partition in Fructus Juglandis 14 parts, Herba Orobanches 8 parts, Angelica gig 23 parts, Folium Viburni Cylindrici 18 parts, Herba Bulbophylli Odoratissim 6 parts, Herba Polygoni Orientalis root 13 parts, Herba Hyperici Patuli 38 parts, Herba Blumeae lanceolariae 28 parts, Radix Macropanacis Rosthornii 13 parts, Herba Passiflorae Wilsonii 8 parts, Radix seu Caulis Kadsurae Heteroclitae 24 parts, Radix Saposhnikoviae 18 parts, 12 parts green for a long time, Herba Adianti Flabellulati 26 parts and Herba Iresines Herbstii 22 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

8. the preparation method of the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

9. the preparation method of the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.