CN112546283A - Polyurethane-based wound dressing containing bletilla polysaccharide and preparation method thereof - Google Patents
Polyurethane-based wound dressing containing bletilla polysaccharide and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a polyurethane-based wound dressing containing bletilla striata polysaccharide and a preparation method thereof. The polyurethane-based wound dressing containing the bletilla striata polysaccharide is prepared by adopting polyurethane hydrogel particles, thermoplastic polyurethane particles, sesame oil, the bletilla striata polysaccharide, pseudo-ginseng, Chinese angelica, yellow wax and vaseline as raw materials and carrying out proper weight proportion.
Description
Technical Field
The invention belongs to the technical field of biomedical materials, and particularly relates to a bletilla striata polysaccharide-containing polyurethane-based wound dressing and a preparation method thereof.
Background
The medical wound dressing covers the skin wound surface to protect the wound, avoids the skin from secondary damage, can provide favorable environment for the healing of the wound, is mainly used for covering sores, wounds or other injuries, and is an important biomedical material.
The common dressing mainly comprises gauze, hydrogel and the like. The gauze is the dressing which is the earliest and the most widely used dressing, and the gauze dressing has the advantages of protecting the wound surface, reducing the invasion of bacteria, having strong absorption capacity of wound surface exudate, being simple to produce and process, having low price and the like. However, the gauze has large pore diameter, poor barrier function and high possibility of bacterial invasion, is easy to dehydrate and adhere to the wound surface, causes secondary mechanical injury during replacement, ensures granulation tissues of the wound surface to grow into meshes of the gauze, and can damage new tissues to cause pain during dressing change.
Hydrogels are a class of polymers having a three-dimensional network structure that can absorb a large amount of water in water to swell and, after swelling, can continue to maintain their original structure without being dissolved. The modern wound healing theory considers that the wet healing is the basis of the wound healing, so that the guarantee of the wound surface wetting in the wound healing process is the necessary requirement of a functional dressing, and the hydrogel is very soft due to the fact that the hydrogel contains a large amount of moisture and can be used as an excellent biomedical material, particularly a novel wound dressing. When the hydrogel is used for wound dressing, the infection of external bacteria and microorganisms to a wound can be reduced, the loss of body fluid is effectively prevented, oxygen can be transmitted to the wound, a certain wettability is maintained, the healing of the wound is accelerated, the fibrinogen is dissolved, the self-dissolving debridement effect is achieved, gel is formed, the exposed nerve endings are protected, the pain is relieved, and the secondary mechanical injury is not easily caused.
The polyurethane hydrogel is a high molecular polymer whose molecular chains are mainly composed of polyurethane, has a three-dimensional network structure, and can swell in water but is insoluble in water. The polyurethane hydrogel has excellent mechanical properties and biocompatibility, so that the research on the application fields of drug sustained release, bionic organs, substance separation, molecular imprinting and the like is emphasized.
Bletilla striata (Bletilla striata) is a perennial herb of Bletilla striata in Orchidaceae, and is a commonly used Chinese medicinal material in China. The dried tuber is used as a medicine, has the effects of stopping bleeding and astringing, clearing heat and promoting diuresis, and reducing swelling and promoting granulation, and is mainly used for treating lung injury hemoptysis, surgical wounds, ulcer pyogenic infections and the like.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a polyurethane-based wound dressing containing bletilla striata polysaccharide and a preparation method thereof. The bletilla striata polysaccharide-containing polyurethane-based wound dressing has the effects of astringing, stopping bleeding, diminishing inflammation, inhibiting bacteria, resisting oxidation, promoting tissue regeneration and body functions, can effectively promote wound healing and shorten wound healing time, and is good in biocompatibility.
The technical scheme adopted by the invention is as follows:
a polyurethane-based wound dressing containing bletilla striata polysaccharide comprises the following raw material components:
5-15 parts of polyurethane hydrogel particles;
20-30 parts by weight of thermoplastic polyurethane particles;
8-12 parts of sesame oil;
4-12 parts of bletilla striata polysaccharide;
2-8 parts of pseudo-ginseng;
2-8 parts of angelica;
2-4 parts of yellow wax;
2-4 parts of vaseline.
Further preferably, the raw material components of the polyurethane-based wound dressing containing the bletilla polysaccharide comprise:
10 parts by weight of polyurethane hydrogel particles;
25 parts by weight of thermoplastic polyurethane particles;
10 parts of sesame oil;
8 parts of bletilla striata polysaccharide;
5 parts of pseudo-ginseng;
5 parts of angelica;
3 parts of yellow wax;
3 parts of vaseline.
The particle size of the yellow wax is 500-800 meshes.
The bletilla polysaccharide is prepared by the following method:
(S1) drying and crushing rhizoma bletillae tubers to obtain rhizoma bletillae fine powder, adding ethanol into the rhizoma bletillae fine powder for reflux extraction, and filtering to obtain medicine residues after extraction is finished;
(S2) after the ethanol contained in the medicine residues is completely volatilized, adding water for heating and leaching, and filtering after leaching to obtain filtrate;
(S3) passing the filtrate through an ion exchange resin and eluting with deionized water, and collecting the eluate;
(S4) concentrating the eluent, and sequentially carrying out alcohol precipitation, filtration, washing and drying to obtain the bletilla striata polysaccharide.
The preparation method of the polyurethane-based wound dressing containing the bletilla striata polysaccharide comprises the following steps:
(1) fully mixing polyurethane hydrogel particles and thermoplastic polyurethane particles, then adding 2-4 times of N, N-dimethylformamide by mass, heating and stirring to fully dissolve, and cooling to room temperature to obtain a polyurethane solution;
(2) adding bletilla striata polysaccharide into the polyurethane solution obtained in the step (1), and stirring at a high speed to obtain a mixture;
(3) drying Notoginseng radix and radix Angelicae sinensis, and pulverizing to obtain Notoginseng radix fine powder and radix Angelicae sinensis fine powder; heating sesame oil, adding the fine powder of pseudo-ginseng and the fine powder of Chinese angelica, and continuously heating for heat preservation and decoction to obtain a decoction;
(4) heating and melting Cera flava, adding vaseline, mixing, adding the cooled decoction, mixing, keeping the temperature constant, decocting, and cooling to obtain paste;
(5) uniformly stirring the mixture in the step (2) and the paste in the step (4) at a high speed to obtain an ointment;
(6) uniformly coating the ointment on release paper, and removing the release paper after vacuum drying to obtain a drug-loaded film; and (3) sticking the medicine-carrying membrane on medical non-woven gauze to obtain the polyurethane-based wound dressing containing the bletilla striata polysaccharide.
In the step (1), the heating temperature is 50-70 ℃.
In the step (2), the high-speed stirring rate is 4000-6000 rpm.
In the step (3), the heating temperature of the sesame oil is 150-.
In the step (4), the temperature for heating and melting the yellow wax is 75-80 ℃; and cooling the decocted material to 70-90 ℃. The inventor of the present application found in long-term research that the yellow wax can better promote the exertion of the drug effect of the drug, and has the efficacy of stopping bleeding, diminishing inflammation and promoting tissue growth, however, the effect of the yellow wax can be significantly weakened or even disappear at high temperature, so the temperature for adding the yellow wax needs to be controlled within a proper range, and preferably, the temperature for heating and melting the yellow wax is 75-80 ℃.
In the step (5), the high-speed stirring speed is 4000-6000 rpm;
in the step (6), the temperature for vacuum drying is 40-60 ℃, and the time for vacuum drying is 1-2 h.
The invention has the beneficial effects that:
the polyurethane-based wound dressing containing the bletilla striata polysaccharide, provided by the invention, is prepared by taking polyurethane hydrogel particles, thermoplastic polyurethane particles, sesame oil, the bletilla striata polysaccharide, pseudo-ginseng, Chinese angelica, beeswax and vaseline as raw materials and carrying out proper weight proportion.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
In the following examples, 100g is represented by 1 part by weight. The starting materials used in the following examples and comparative examples were all commercially available products except for the specific ones.
Example 1
The embodiment provides a polyurethane-based wound dressing containing bletilla striata polysaccharide, which comprises the following raw material components:
5 parts by weight of polyurethane hydrogel particles;
30 parts by weight of thermoplastic polyurethane particles;
8 parts of sesame oil;
12 parts of bletilla striata polysaccharide;
2 parts of pseudo-ginseng;
8 parts of angelica;
2 parts by weight of yellow wax with the particle size of 500 meshes;
4 parts of vaseline.
The bletilla polysaccharide is prepared by the following method:
(S1) drying and crushing rhizoma bletillae tubers to obtain fine rhizoma bletillae powder with the particle size of 80nm, adding 2 times of ethanol with the mass and volume concentration of 80% into the fine rhizoma bletillae powder, carrying out reflux extraction under the heating condition, and filtering after extraction is finished to obtain medicine residues;
(S2) after the ethanol contained in the medicine residues is completely volatilized, adding 2 times of water by mass, heating and leaching for 5 hours at 100 ℃, and filtering after leaching is finished to obtain filtrate;
(S3) passing the filtrate through macroporous weakly-basic anion resin and macroporous weakly-acidic cation resin in sequence, eluting with deionized water, and collecting the eluate;
(S4) concentrating the eluent to the relative density of 1.1, adding 80% ethanol by volume concentration for alcohol precipitation, filtering the precipitate, washing with alcohol, and drying to obtain the bletilla striata polysaccharide.
Further, this example provides a method for preparing the polyurethane-based wound dressing containing bletilla striata polysaccharide, comprising the following steps:
(1) fully mixing polyurethane hydrogel particles and thermoplastic polyurethane particles, adding 2 times of N, N-dimethylformamide by mass, heating to 50 ℃, stirring to fully dissolve, and cooling to room temperature to obtain a polyurethane solution;
(2) adding bletilla striata polysaccharide into the polyurethane solution obtained in the step (1), and stirring at a high speed of 4000rpm to obtain a mixture;
(3) drying Notoginseng radix and radix Angelicae sinensis, and pulverizing to obtain Notoginseng radix fine powder and radix Angelicae sinensis fine powder; heating sesame oil to 150 ℃, adding the fine powder of the pseudo-ginseng and the fine powder of the Chinese angelica, continuing heating, keeping the temperature and decocting for 2 hours to obtain a decoction;
(4) heating and melting Cera flava at 75 deg.C, adding vaseline, mixing, adding the decoction cooled to 70 deg.C, mixing, keeping the temperature constant, decocting, and cooling to obtain paste;
(5) uniformly stirring the mixture in the step (2) and the paste in the step (4) at a high speed of 4000rpm to obtain an ointment;
(6) uniformly coating the ointment on release paper, then carrying out vacuum drying at 40 ℃ for 2h, and removing the release paper to obtain a drug-loaded film; and (3) sticking the medicine-carrying membrane on medical non-woven gauze to obtain the polyurethane-based wound dressing containing the bletilla striata polysaccharide.
Example 2
The embodiment provides a polyurethane-based wound dressing containing bletilla striata polysaccharide, which comprises the following raw material components:
15 parts by weight of polyurethane hydrogel particles;
20 parts by weight of thermoplastic polyurethane particles;
12 parts of sesame oil;
4 parts of bletilla striata polysaccharide;
8 parts of pseudo-ginseng;
2 parts of angelica;
4 parts by weight of yellow wax with the particle size of 800 meshes;
2 parts of vaseline.
The bletilla polysaccharide is prepared by the following method:
(S1) drying and crushing rhizoma bletillae tubers to obtain rhizoma bletillae fine powder with the particle size of 120nm, adding 3 times of ethanol with the mass and volume concentration of 95% into the rhizoma bletillae fine powder, carrying out reflux extraction under the heating condition, and filtering after extraction is finished to obtain medicine residues;
(S2) after the ethanol contained in the dregs of a decoction is completely volatilized, adding 8 times of mass water, heating and leaching at 82 ℃ for 5-8h, and filtering after leaching is finished to obtain filtrate;
(S3) passing the filtrate through macroporous weakly-basic anion resin and macroporous weakly-acidic cation resin in sequence, eluting with deionized water, and collecting the eluate;
(S4) concentrating the eluent to the relative density of 1.3, adding ethanol with the volume concentration of 95% for alcohol precipitation, filtering the precipitate, washing with alcohol, and drying to obtain the bletilla striata polysaccharide.
Further, this example provides a method for preparing the polyurethane-based wound dressing containing bletilla striata polysaccharide, comprising the following steps:
(1) fully mixing polyurethane hydrogel particles and thermoplastic polyurethane particles, adding 4 times of N, N-dimethylformamide by mass, heating to 70 ℃, stirring to fully dissolve, and cooling to room temperature to obtain a polyurethane solution;
(2) adding bletilla striata polysaccharide into the polyurethane solution obtained in the step (1), and stirring at a high speed of 6000rpm to obtain a mixture;
(3) drying Notoginseng radix and radix Angelicae sinensis, and pulverizing to obtain Notoginseng radix fine powder and radix Angelicae sinensis fine powder; heating sesame oil to 160 ℃, adding the fine powder of the pseudo-ginseng and the fine powder of the Chinese angelica, continuing heating, keeping the temperature and decocting for 3 hours to obtain a decoction;
(4) heating and melting Cera flava at 80 deg.C, adding vaseline, mixing, adding the decoction cooled to 90 deg.C, mixing, keeping the temperature constant, decocting, and cooling to obtain paste;
(5) uniformly stirring the mixture in the step (2) and the paste in the step (4) at a high speed of 6000rpm to obtain an ointment;
(6) uniformly coating the ointment on release paper, then carrying out vacuum drying at 60 ℃ for 1h, and removing the release paper to obtain a drug-loaded film; and (3) sticking the medicine-carrying membrane on medical non-woven gauze to obtain the polyurethane-based wound dressing containing the bletilla striata polysaccharide.
Example 3
The embodiment provides a polyurethane-based wound dressing containing bletilla striata polysaccharide, which comprises the following raw material components:
10 parts by weight of polyurethane hydrogel particles;
25 parts by weight of thermoplastic polyurethane particles;
10 parts of sesame oil;
8 parts of bletilla striata polysaccharide;
5 parts of pseudo-ginseng;
5 parts of angelica;
3 parts by weight of yellow wax with the particle size of 650 meshes;
3 parts of vaseline.
The bletilla polysaccharide is prepared by the following method:
(S1) drying and crushing rhizoma bletillae tubers to obtain rhizoma bletillae fine powder with the particle size of 100nm, adding 2.5 times of ethanol with the volume concentration of 90% into the rhizoma bletillae fine powder, carrying out reflux extraction under the heating condition, and filtering after the extraction is finished to obtain medicine residues;
(S2) after the ethanol contained in the medicine residues is completely volatilized, adding 5 times of mass water, heating and leaching at 90 ℃ for 6 hours, and filtering after leaching is finished to obtain filtrate;
(S3) passing the filtrate through macroporous weakly-basic anion resin and macroporous weakly-acidic cation resin in sequence, eluting with deionized water, and collecting the eluate;
(S4) concentrating the eluent to the relative density of 1.2, adding ethanol with the volume concentration of 90% for alcohol precipitation, filtering the precipitate, washing with alcohol, and drying to obtain the bletilla striata polysaccharide.
Further, this example provides a method for preparing the polyurethane-based wound dressing containing bletilla striata polysaccharide, comprising the following steps:
(1) fully mixing polyurethane hydrogel particles and thermoplastic polyurethane particles, adding N, N-dimethylformamide with the mass of 3 times of that of the polyurethane hydrogel particles, heating to 60 ℃, stirring to fully dissolve the N, N-dimethylformamide, and cooling to room temperature to obtain a polyurethane solution;
(2) adding bletilla striata polysaccharide into the polyurethane solution obtained in the step (1), and stirring at a high speed of 5000rpm to obtain a mixture;
(3) drying Notoginseng radix and radix Angelicae sinensis, and pulverizing to obtain Notoginseng radix fine powder and radix Angelicae sinensis fine powder; heating oleum Sesami to 155 deg.C, adding the Notoginseng radix fine powder and radix Angelicae sinensis fine powder, heating, and decocting for 2.5 hr to obtain decoction;
(4) heating and melting Cera flava at 78 deg.C, adding vaseline, mixing, adding the decoction cooled to 80 deg.C, mixing, keeping the temperature constant, decocting, and cooling to obtain paste;
(5) stirring the mixture in the step (2) and the paste in the step (4) at a high speed of 5000rpm, and uniformly mixing to obtain an ointment;
(6) uniformly coating the ointment on release paper, then carrying out vacuum drying at 50 ℃ for 1.5h, and removing the release paper to obtain a drug-loaded film; and (3) sticking the medicine-carrying membrane on medical non-woven gauze to obtain the polyurethane-based wound dressing containing the bletilla striata polysaccharide.
Example 4
The embodiment provides a polyurethane-based wound dressing containing bletilla striata polysaccharide, which comprises the following raw material components:
12 parts by weight of polyurethane hydrogel particles;
22 parts by weight of thermoplastic polyurethane particles;
9 parts of sesame oil;
10 parts of bletilla striata polysaccharide;
6 parts of pseudo-ginseng;
6 parts of angelica;
yellow wax with the particle size of 600 meshes, 3 parts by weight;
3 parts of vaseline.
The bletilla polysaccharide is prepared by the following method:
(S1) drying and crushing rhizoma bletillae tubers to obtain rhizoma bletillae fine powder with the particle size of 100nm, adding 2.5 times of ethanol with the volume concentration of 90% into the rhizoma bletillae fine powder, carrying out reflux extraction under the heating condition, and filtering after the extraction is finished to obtain medicine residues;
(S2) after the ethanol contained in the medicine residues is completely volatilized, adding 5 times of mass water, heating and leaching at 90 ℃ for 6 hours, and filtering after leaching is finished to obtain filtrate;
(S3) passing the filtrate through macroporous weakly-basic anion resin and macroporous weakly-acidic cation resin in sequence, eluting with deionized water, and collecting the eluate;
(S4) concentrating the eluent to the relative density of 1.2, adding ethanol with the volume concentration of 90% for alcohol precipitation, filtering the precipitate, washing with alcohol, and drying to obtain the bletilla striata polysaccharide.
Further, this example provides a method for preparing the polyurethane-based wound dressing containing bletilla striata polysaccharide, comprising the following steps:
(1) fully mixing polyurethane hydrogel particles and thermoplastic polyurethane particles, adding N, N-dimethylformamide with the mass of 3 times of that of the polyurethane hydrogel particles, heating to 60 ℃, stirring to fully dissolve the N, N-dimethylformamide, and cooling to room temperature to obtain a polyurethane solution;
(2) adding bletilla striata polysaccharide into the polyurethane solution in the step (1), and stirring at a high speed of 5500rpm to prepare a mixture;
(3) drying Notoginseng radix and radix Angelicae sinensis, and pulverizing to obtain Notoginseng radix fine powder and radix Angelicae sinensis fine powder; heating oleum Sesami to 155 deg.C, adding the Notoginseng radix fine powder and radix Angelicae sinensis fine powder, heating, and decocting for 2.5 hr to obtain decoction;
(4) heating and melting Cera flava at 76 deg.C, adding vaseline, mixing, adding the decoction cooled to 75 deg.C, mixing, keeping the temperature constant, decocting, and cooling to obtain paste;
(5) stirring the mixture in the step (2) and the paste in the step (4) at a high speed of 5500rpm, and uniformly mixing to obtain an ointment;
(6) uniformly coating the ointment on release paper, then carrying out vacuum drying at 55 ℃ for 1.5h, and removing the release paper to obtain a drug-loaded film; and (3) sticking the medicine-carrying membrane on medical non-woven gauze to obtain the polyurethane-based wound dressing containing the bletilla striata polysaccharide.
Comparative example 1
The comparative example provides a polyurethane-based wound dressing containing bletilla striata polysaccharide, which is different from the wound dressing in example 3 only in that bletilla striata polysaccharide is not added in the raw materials, other raw materials and the using amount are the same as those in example 3, and the specific preparation method is as follows:
(1) fully mixing polyurethane hydrogel particles and thermoplastic polyurethane particles, adding N, N-dimethylformamide with the mass of 3 times of that of the polyurethane hydrogel particles, heating to 60 ℃, stirring to fully dissolve the N, N-dimethylformamide, and cooling to room temperature to obtain a polyurethane solution;
(2) drying Notoginseng radix and radix Angelicae sinensis, and pulverizing to obtain Notoginseng radix fine powder and radix Angelicae sinensis fine powder; heating oleum Sesami to 155 deg.C, adding the Notoginseng radix fine powder and radix Angelicae sinensis fine powder, heating, and decocting for 2.5 hr to obtain decoction;
(3) heating and melting Cera flava at 78 deg.C, adding vaseline, mixing, adding the decoction cooled to 80 deg.C, mixing, keeping the temperature constant, decocting, and cooling to obtain paste;
(4) stirring and uniformly mixing the polyurethane solution in the step (1) and the paste in the step (3) at a high speed of 5000rpm to obtain an ointment;
(5) uniformly coating the ointment on release paper, then carrying out vacuum drying at 50 ℃ for 1.5h, and removing the release paper to obtain a drug-loaded film; and (3) sticking the medicine-carrying membrane on medical non-woven gauze to obtain the polyurethane-based wound dressing containing the bletilla striata polysaccharide.
Comparative example 2
The comparative example provides a polyurethane-based wound dressing containing bletilla striata polysaccharide, which is different from the wound dressing in example 3 only in that no yellow wax is added in the raw materials, and other raw materials and the using amount are the same as those in example 3, and the specific preparation method is as follows:
(1) fully mixing polyurethane hydrogel particles and thermoplastic polyurethane particles, adding N, N-dimethylformamide with the mass of 3 times of that of the polyurethane hydrogel particles, heating to 60 ℃, stirring to fully dissolve the N, N-dimethylformamide, and cooling to room temperature to obtain a polyurethane solution;
(2) adding bletilla striata polysaccharide into the polyurethane solution obtained in the step (1), and stirring at a high speed of 5000rpm to obtain a mixture;
(3) drying Notoginseng radix and radix Angelicae sinensis, and pulverizing to obtain Notoginseng radix fine powder and radix Angelicae sinensis fine powder; heating oleum Sesami to 155 deg.C, adding the Notoginseng radix fine powder and radix Angelicae sinensis fine powder, heating, and decocting for 2.5 hr to obtain decoction;
(4) adding vaseline into the decoction cooled to 80 deg.C, mixing, keeping the temperature constant, decocting, and cooling to obtain paste;
(5) stirring the mixture in the step (2) and the paste in the step (4) at a high speed of 5000rpm, and uniformly mixing to obtain an ointment;
(6) uniformly coating the ointment on release paper, then carrying out vacuum drying at 50 ℃ for 1.5h, and removing the release paper to obtain a drug-loaded film; and (3) sticking the medicine-carrying membrane on medical non-woven gauze to obtain the polyurethane-based wound dressing containing the bletilla striata polysaccharide.
Comparative example 3
The comparative example provides a bletilla striata polysaccharide-containing polyurethane-based wound dressing, and the difference from the example 3 is only that in the step (4), the temperature for boiling the yellow wax is 85 ℃, and other raw materials and preparation methods are the same.
Comparative example 4
This comparative example provides a bletilla striata polysaccharide containing polyurethane based wound dressing, which differs from example 3 only in that the particle size of the raw material added yellow wax is 400 mesh, and the other raw materials and preparation method are the same as example 3.
Examples of the experiments
In order to examine the wound-healing-promoting properties of the wound dressings obtained in example 3 and comparative examples 1 to 4, the specific steps were: a mouse bacterial infection wound model is constructed, the dressing is used for treating bacterial infection, the dressing is replaced once a day, the wound healing conditions are observed on the 3 rd day, the 7 th day and the 14 th day respectively for comparative evaluation, and the results are shown in Table 1.
TABLE 1 comparison of the speed of promotion of wound healing by different dressings
As can be seen from table 1, the dressing prepared by the method described in example 3 can effectively promote wound healing and shorten the wound healing time, whereas the dressings obtained in comparative examples 1 to 4 are relatively speaking, especially comparative example 1, because no bletilla striata polysaccharide is added in the raw materials, the wound healing speed is slowest, which indicates that the bletilla striata polysaccharide plays a key role in promoting wound healing of the dressing. The comparative example 2 is not added with the yellow wax, the wound healing effect is not good, the yellow wax plays a good role in promoting the wound healing efficacy of the dressing, the comparative examples 3 and 4 are added with the yellow wax, the yellow wax efficacy can be damaged when the temperature is too high, and the yellow wax efficacy can be influenced when the particle size is too large.
The present invention is not limited to the above-mentioned preferred embodiments, and any other products in various forms can be obtained by anyone in the light of the present invention, but any changes in the shape or structure thereof, which have the same or similar technical solutions as those of the present application, fall within the protection scope of the present invention.
Claims (10)
1. A polyurethane-based wound dressing containing bletilla striata polysaccharide is characterized by comprising the following raw material components:
5-15 parts of polyurethane hydrogel particles;
20-30 parts by weight of thermoplastic polyurethane particles;
8-12 parts of sesame oil;
4-12 parts of bletilla striata polysaccharide;
2-8 parts of pseudo-ginseng;
2-8 parts of angelica;
2-4 parts of yellow wax;
2-4 parts of vaseline.
2. The polyurethane-based wound dressing containing bletilla striata polysaccharide according to claim 1, wherein the raw material components comprise:
10 parts by weight of polyurethane hydrogel particles;
25 parts by weight of thermoplastic polyurethane particles;
10 parts of sesame oil;
8 parts of bletilla striata polysaccharide;
5 parts of pseudo-ginseng;
5 parts of angelica;
3 parts of yellow wax;
3 parts of vaseline.
3. The polyurethane-based wound dressing containing rhizoma bletillae polysaccharides as claimed in claim 1 or 2, wherein the particle size of the yellow wax is 500-800 mesh.
4. The polyurethane-based wound dressing containing bletilla polysaccharide according to claim 1 or 2, wherein the bletilla polysaccharide is prepared by the following method:
(S1) drying and crushing rhizoma bletillae tubers to obtain rhizoma bletillae fine powder, adding ethanol into the rhizoma bletillae fine powder for reflux extraction, and filtering to obtain medicine residues after extraction is finished;
(S2) after the ethanol contained in the medicine residues is completely volatilized, adding water for heating and leaching, and filtering after leaching to obtain filtrate;
(S3) passing the filtrate through an ion exchange resin and eluting with deionized water, and collecting the eluate;
(S4) concentrating the eluent, and sequentially carrying out alcohol precipitation, filtration, washing and drying to obtain the bletilla striata polysaccharide.
5. The process for preparing a polyurethane-based wound dressing containing bletilla striata polysaccharides as claimed in any one of claims 1 to 4, wherein the steps include:
(1) fully mixing polyurethane hydrogel particles and thermoplastic polyurethane particles, then adding 2-4 times of N, N-dimethylformamide by mass, heating and stirring to fully dissolve, and cooling to room temperature to obtain a polyurethane solution;
(2) adding bletilla striata polysaccharide into the polyurethane solution obtained in the step (1), and stirring at a high speed to obtain a mixture;
(3) drying Notoginseng radix and radix Angelicae sinensis, and pulverizing to obtain Notoginseng radix fine powder and radix Angelicae sinensis fine powder; heating sesame oil, adding the fine powder of pseudo-ginseng and the fine powder of Chinese angelica, and continuously heating for heat preservation and decoction to obtain a decoction;
(4) heating and melting Cera flava, adding vaseline, mixing, adding the cooled decoction, mixing, keeping the temperature constant, decocting, and cooling to obtain paste;
(5) uniformly stirring the mixture in the step (2) and the paste in the step (4) at a high speed to obtain an ointment;
(6) uniformly coating the ointment on release paper, and removing the release paper after vacuum drying to obtain a drug-loaded film; and (3) sticking the medicine-carrying membrane on medical non-woven gauze to obtain the polyurethane-based wound dressing containing the bletilla striata polysaccharide.
6. The method for preparing a polyurethane-based wound dressing containing bletilla striata polysaccharide as claimed in claim 5, wherein the heating temperature in step (1) is 50-70 ℃.
7. The method for preparing a polyurethane-based wound dressing containing bletilla striata polysaccharide as claimed in claim 5, wherein the high speed stirring rate in step (2) is 4000-6000 rpm.
8. The method for preparing a polyurethane-based wound dressing containing bletilla striata polysaccharide as claimed in claim 5, wherein in the step (3), the heating temperature of the sesame oil is 150-.
9. The preparation method of polyurethane-based wound dressing containing bletilla striata polysaccharide as claimed in claim 5, wherein in the step (4), the temperature for melting the yellow wax by heating is 75-80 ℃; and cooling the decocted material to 70-90 ℃.
10. The method for preparing a polyurethane-based wound dressing containing bletilla striata polysaccharide as claimed in claim 5, wherein in step (5), the high speed stirring rate is 4000-6000 rpm;
in the step (6), the temperature for vacuum drying is 40-60 ℃, and the time for vacuum drying is 1-2 h.
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| CN116549570A (en) * | 2023-06-15 | 2023-08-08 | 陕西科技大学 | Selaginella tamariscina essential oil burn cream and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108283726A (en) * | 2018-03-05 | 2018-07-17 | 湖南科技大学 | A kind of preparation method of polyurethane wound dressing |
| CN110201210A (en) * | 2018-07-27 | 2019-09-06 | 武汉纺织大学 | A kind of preparation method of bletilla striata dressing easy to operate |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108283726A (en) * | 2018-03-05 | 2018-07-17 | 湖南科技大学 | A kind of preparation method of polyurethane wound dressing |
| CN110201210A (en) * | 2018-07-27 | 2019-09-06 | 武汉纺织大学 | A kind of preparation method of bletilla striata dressing easy to operate |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116549570A (en) * | 2023-06-15 | 2023-08-08 | 陕西科技大学 | Selaginella tamariscina essential oil burn cream and preparation method thereof |
| CN116549570B (en) * | 2023-06-15 | 2024-05-07 | 陕西科技大学 | Selaginella tamariscina essential oil burn cream and preparation method thereof |
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