CN114931662B - Skin care dressing and preparation method thereof - Google Patents
Skin care dressing and preparation method thereof Download PDFInfo
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- CN114931662B CN114931662B CN202210483417.2A CN202210483417A CN114931662B CN 114931662 B CN114931662 B CN 114931662B CN 202210483417 A CN202210483417 A CN 202210483417A CN 114931662 B CN114931662 B CN 114931662B
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- carboxymethyl cellulose
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- skin care
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- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 71
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 71
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 70
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 70
- 239000000843 powder Substances 0.000 claims abstract description 63
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 44
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- 150000001450 anions Chemical class 0.000 claims abstract description 32
- 239000000419 plant extract Substances 0.000 claims abstract description 30
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000661 sodium alginate Substances 0.000 claims abstract description 17
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 17
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 17
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- 235000011399 aloe vera Nutrition 0.000 claims abstract description 14
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 13
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 11
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- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
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- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
- C08B15/02—Oxycellulose; Hydrocellulose; Cellulosehydrate, e.g. microcrystalline cellulose
- C08B15/04—Carboxycellulose, e.g. prepared by oxidation with nitrogen dioxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a skin care dressing and a preparation method thereof, wherein the skin care dressing is prepared from the following raw materials in parts by weight: 50-70 parts of sodium alginate, 5-10 parts of hyaluronic acid, 3-7 parts of aloe juice, 2-6 parts of honey, 30-50 parts of modified carboxymethyl cellulose, 2-4 parts of glycerol, 5-10 parts of plant extract and 3-6 parts of modified anion powder. The dressing prepared by the invention has good antibacterial and anti-inflammatory effects, can rapidly stop bleeding of skin wounds, provides a good environment for wound repair of skin tissues, achieves better effect of helping skin recovery, and reduces healing time of wound wounds; meanwhile, the dressing has long-time antibacterial effect, prolongs the service time of the dressing, and reduces the dressing change times of patients.
Description
Technical Field
The invention belongs to the technical field of medical dressing, and particularly relates to a skin care dressing and a preparation method thereof.
Background
Skin is an important organ in human body construction, and mainly plays roles in protecting body, preventing water loss and bacterial infection, and has the functions of immunity and sensing. When skin injury such as burn, scald and the like is caused by external factors, the injured skin can be infected by bacteria in air or contact, and water and protein are lost, and life is threatened seriously, therefore, the medical dressing can be used for replacing the injured skin to cover the wound surface, so that the bacterial infection and the water loss are prevented, and the skin protection effect is achieved.
The medical dressing is a medical material covering the wound and can replace skin to play a temporary barrier role. The covered dressing has the functions of protecting wound surface, preventing body fluid/protein loss and preventing inflammation caused by bacterial invasion, and can also be added with components such as growth factors and the like to promote wound healing. Therefore, in the case of skin with large area defect or difficult healing, it is very important to cover the surface of the skin with skin dressing for repair. Therefore, the development of the skin dressing for replacing normal skin of human body has important significance for repairing human skin.
The existing medical dressings are various, but can not effectively form a good protective barrier environment for the wound surface, so that secondary pollution of the skin wound surface is caused, inflammation is then initiated, and the recovery time of the wound surface and the repair time of the skin barrier are prolonged. Therefore, the medical dressing is particularly important for constructing a screen closed environment when the skin is damaged, and an ideal wound repair environment is required to have good air permeability and barrier function under the condition of effectively keeping the wound moist, and Chinese patent CN106512064B discloses a skin wound dressing with antibacterial performance and a preparation method thereof, has good biocompatibility, antibacterial performance and induction repair function, can promote the healing of a wound surface and the growth of epithelial cells, and is beneficial to re-epithelialization of the wound surface.
In response to the need for skin care, the novel skin dressing should meet the following conditions: (1) a physical barrier; (2) controlling fluid on the wound; (3) controlling odors generated on the wound; (4) controlling bacteria and microorganisms on the wound; (5) low adhesion; (6) decrustation; (7) hemostatic effect; (8) modulating the metal ion content of the wound periphery; (9) accelerating the healing rate of wounds. The development of the novel skin care dressing is considered from the perspective of a patient, the dressing change times are reduced as much as possible, the pain caused by dressing change is relieved, the requirements of sustainable development and renewable resources are met, green production is maintained, and more novel degradable biological materials are developed and applied to the skin care dressing.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a skin care dressing and a preparation method thereof, wherein the dressing has good antibacterial and anti-inflammatory effects, can rapidly stop bleeding of skin wounds, provides a good environment for wound repair of skin tissues, achieves better effect of helping skin recovery, and reduces healing time of wound wounds; meanwhile, the dressing has long-time antibacterial effect, prolongs the service time of the dressing, and reduces the dressing change times of patients.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the skin care dressing is prepared from the following raw materials in parts by weight:
preferably, the preparation method of the modified carboxymethyl cellulose comprises the following steps:
(a) Adding carboxymethyl cellulose into deionized water, stirring for dissolution, then adding N-hydroxysuccinimide, heating for reaction, concentrating under reduced pressure after the reaction is completed, and drying to obtain activated carboxymethyl cellulose;
(b) Adding the activated carboxymethyl cellulose obtained in the step (a) into an 80% ethanol solution, then adding p-hydroxyphenylethylamine, stirring for reaction, concentrating and drying after the reaction is finished, and obtaining the carboxymethyl cellulose containing phenol groups, namely the modified carboxymethyl cellulose.
Preferably, the mass ratio of the carboxymethyl cellulose to the N-hydroxysuccinimide in the step (a) is 100:5-15; the heating reaction temperature is 50-70 ℃ and the reaction time is 3-5h.
Preferably, the mass ratio of the activated carboxymethyl cellulose to the p-hydroxyphenylethylamine in the step (b) is 100:20-30 parts; the stirring reaction temperature is 70-80 ℃ and the reaction time is 4-8h.
Preferably, the preparation method of the plant extract comprises the following steps:
weighing fructus forsythiae, herba Violae, radix Tripterygii Wilfordii, fructus Piperis Longi, flos Rosae Rugosae and herba Cymbopogonis Citrari, mixing, grinding, adding into 60% ethanol solution, soaking at room temperature for 6-10 hr, ultrasonic extracting, and filtering to obtain first extractive solution and residue; adding 70% ethanol solution into the filter residue, performing reflux extraction, and filtering after extraction to obtain a second extract; combining the first extract with the second extract, concentrating under reduced pressure, and recovering ethanol to obtain the plant extract.
Preferably, the mass ratio of the weeping forsythiae capsule to the viola philippica to the common threewingnut root to the common rose and the citronella is 1:1-2:0.5-1:0.5-1.5:2-3:1-2; the ultrasonic extraction temperature is 40-50deg.C, and the extraction time is 20-30min; the reflux extraction temperature is 75-85 ℃, and the extraction time is 3-6h.
Preferably, the preparation method of the modified anion powder comprises the following steps:
s1, washing and sterilizing anion powder, adding the anion powder into absolute ethyl alcohol, soaking for 2-4 hours, then adding KH550, putting the powder into a ball milling tank at room temperature for ball milling, and drying after ball milling is finished to obtain surface modified anion powder;
s2, adding the surface modified anion powder obtained in the step S1 into deionized water, adding dopamine hydrochloride under stirring for soaking for 20-40min, then adding trihydroxy aminomethane to adjust the pH to 9.5, carrying out a light-shielding reaction, and washing and drying after the reaction is completed to obtain the modified anion powder.
Preferably, in step S1, the mass ratio of the negative ion powder to KH550 is 100:1-3, wherein the ball milling rotating speed is 2000-3000r/min, and the ball milling time is 1-3h; in the step S2, the addition amount of the dopamine hydrochloride is 4-8g/L, the light-shielding reaction temperature is 25-35 ℃, and the reaction time is 6-10h.
The invention also provides a preparation method of the skin care dressing, which comprises the following steps:
(1) Adding sodium alginate, aloe juice, honey, glycerol and plant extract into deionized water according to a certain proportion, uniformly stirring, then adding modified anion powder, and carrying out heat preservation reaction under the stirring condition to obtain a mixture after the reaction is completed;
(2) Adding hyaluronic acid and modified carboxymethyl cellulose into the mixture obtained in the step (1), stirring for reaction, placing at 0-5 ℃ for 6-10h after the reaction is completed, and then sterilizing to obtain the skin care dressing.
Preferably, the temperature of the thermal insulation reaction in the step (1) is 40-60 ℃, and the reaction time is 3-7h; in the step (2), the stirring reaction temperature is 40-50 ℃ and the reaction time is 2-5h.
Compared with the prior art, the invention has the following beneficial effects:
(1) According to the skin care dressing provided by the invention, carboxymethyl cellulose is modified, carboxymethyl in the carboxymethyl cellulose is activated by reacting N-hydroxysuccinimide with the carboxymethyl cellulose, so that the reaction activity of the carboxymethyl is improved, and then p-hydroxyphenylethylamine is added and grafted to the carboxymethyl cellulose to obtain the carboxymethyl cellulose containing phenol groups; through the modified carboxymethyl cellulose, the modified carboxymethyl cellulose can carry out crosslinking reaction with sodium alginate in the subsequent dressing preparation process, can coat substances such as plant extract with anti-inflammatory and bactericidal functions and the like therein, and can effectively play the role of a carrier. Meanwhile, the sodium alginate and the carboxymethyl cellulose have good hemostatic effect, so that the good environment is provided for wound repair of skin tissues, and the aloe juice and the honey have the effect of promoting skin wound healing, can better help the skin recovery, and reduce the healing time of wound surfaces.
(2) In the skin care dressing provided by the invention, in the added plant extract, the weeping forsythia has the effects of clearing away heat and toxic materials, eliminating scars and resolving hard mass, and dispelling wind and heat, and has a very strong inhibition effect on staphylococcus aureus and shigella dysenteriae, and a certain inhibition effect on other pathogenic bacteria, influenza viruses and fungi; herba Violae has effects of clearing heat and detoxicating, cooling blood, eliminating scar and resolving hard mass; tripterygium wilfordii has effects of dispelling pathogenic wind, removing dampness, promoting blood circulation, dredging collaterals, relieving swelling, relieving pain, killing parasite and removing toxic substances; bai Jili has effects of suppressing hyperactive liver, resolving stagnation, promoting blood circulation, dispelling pathogenic wind, relieving itching, improving eyesight, and inhibiting growth of Staphylococcus aureus and Escherichia coli; the rose has the functions of regulating qi, resolving stagnation, regulating blood and removing blood stasis, and simultaneously has the effects of resisting virus, inhibiting bacteria, diminishing inflammation and moisturizing skin; the citronella has the functions of dispelling wind, dredging collaterals, warming middle-jiao and relieving pain, and the volatile oil contained in the citronella has antifungal effect; through reasonable compounding of the substances, the extract obtained by a scientific method can activate the immune system of a human body, promote wound healing, improve the quantity of red blood cells and white blood cells, prolong the antibacterial and anti-inflammatory action time of the dressing, reduce the times of dressing change of a patient, and is nontoxic and harmless to the human body.
(3) According to the skin care dressing provided by the invention, the added negative ion powder is subjected to wet ball milling modification, so that the surface of the negative ion powder is activated, the surface activation energy of the negative ion powder is improved, the agglomeration effect of the negative ion powder is reduced, and the release amount of the negative ion is improved; KH550 is coated on the surface of the negative ion powder, so that the subsequent functional modification on the surface of the negative ion powder is facilitated; then, through in-situ synthesis of polydopamine on the surface of the negative ions, the polydopamine has good compatibility with other substances in the dressing, and meanwhile, compared with the direct use of the negative ion powder after the negative ion powder is modified by the dopamine, the negative ion powder does not generate allergic reaction on skin, so that the dressing has greater universality.
Detailed Description
The technical solutions of the present invention will be clearly and completely described in connection with the embodiments, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The aloe juice is aloe CORP CO2; the negative ion powder is purchased from Hebei Humanmann mineral products limited company; the carboxymethyl cellulose is purchased from the company of Fangfang Xingmai cellulose Limited; the sodium alginate was purchased from Hebei Runfu Biotechnology Co.
Example 1
A method of preparing the skin care dressing comprising the steps of:
(1) Adding 500g of sodium alginate, 30g of aloe juice, 20g of honey, 20g of glycerol and 50g of plant extract into 2L of deionized water, uniformly stirring, then adding 30g of modified anion powder, and carrying out heat preservation reaction for 7h at 40 ℃ under the stirring condition, thus obtaining a mixture after the reaction is completed;
(2) Adding 50g of hyaluronic acid and 30g of modified carboxymethyl cellulose into the mixture in the step (1), stirring at 40 ℃ for reaction for 5 hours, placing at 0 ℃ for 6 hours after the reaction is finished, and then sterilizing to obtain the skin care dressing.
The preparation method of the modified carboxymethyl cellulose comprises the following steps:
(a) Adding 100g of carboxymethyl cellulose into 500mL of deionized water, stirring for dissolution, then adding 5g of N-hydroxysuccinimide, heating for reaction at 50 ℃ for 5 hours, and concentrating under reduced pressure and drying after the reaction is completed to obtain activated carboxymethyl cellulose;
(b) Adding 100g of activated carboxymethyl cellulose obtained in the step (a) into 500mL of 80% ethanol solution, then adding 20g of p-hydroxyphenylethylamine, stirring for reaction at 70 ℃ for 8 hours, concentrating and drying after the reaction is completed to obtain carboxymethyl cellulose containing phenol groups, namely the modified carboxymethyl cellulose.
The preparation method of the plant extract comprises the following steps:
weighing 100g of fructus forsythiae, 100g of herba violae, 50g of tripterygium wilfordii, 50g of white jili, 200g of rose and 100g of citronella, uniformly mixing, grinding, adding into 1L of 60% ethanol solution, soaking for 6 hours at room temperature, extracting by ultrasonic waves at 40 ℃ for 30min, and filtering to obtain a first extract and filter residues; adding 1L of 70% ethanol solution into the filter residue, carrying out reflux extraction at 75 ℃ for 6 hours, and filtering after extraction to obtain a second extract; combining the first extract with the second extract, concentrating under reduced pressure, and recovering ethanol to obtain the plant extract.
The preparation method of the modified negative ion powder comprises the following steps:
s1, adding 100g of negative ion powder into 500mL of absolute ethyl alcohol after washing and sterilizing treatment, soaking for 2 hours, then adding 1g of KH550, putting into a ball milling tank at room temperature for ball milling at the speed of 2000r/min for 3 hours, and drying after ball milling to obtain surface modified negative ion powder;
s2, adding the surface modified anion powder obtained in the step S1 into deionized water, adding 500mL of 4g/L dopamine hydrochloride under stirring for soaking for 20min, then adding trihydroxy aminomethane to adjust the pH to 9.5, carrying out light-proof reaction at the reaction temperature of 25 ℃ for 10h, and washing and drying after the reaction is completed to obtain the modified anion powder.
Example 2
A method of preparing the skin care dressing comprising the steps of:
(1) Adding 600g of sodium alginate, 50g of aloe juice, 40g of honey, 30g of glycerol and 70g of plant extract into 2L of deionized water, uniformly stirring, then adding 50g of modified anion powder, and carrying out heat preservation reaction for 5 hours at 50 ℃ under the stirring condition, thus obtaining a mixture after the reaction is completed;
(2) Adding 80g of hyaluronic acid and 40g of modified carboxymethyl cellulose into the mixture in the step (1), stirring at 45 ℃ for reaction for 4 hours, placing at 3 ℃ for 8 hours after the reaction is finished, and then sterilizing to obtain the skin care dressing.
The preparation method of the modified carboxymethyl cellulose comprises the following steps:
(a) Adding 100g of carboxymethyl cellulose into 500mL of deionized water, stirring for dissolution, then adding 10g N-hydroxysuccinimide, heating for reaction at 60 ℃ for 4 hours, and concentrating under reduced pressure and drying after the reaction is completed to obtain activated carboxymethyl cellulose;
(b) Adding 100g of activated carboxymethyl cellulose obtained in the step (a) into 500mL of 80% ethanol solution, then adding 25g of p-hydroxyphenylethylamine, stirring for reaction at the reaction temperature of 75 ℃ for 6 hours, concentrating and drying after the reaction is completed to obtain carboxymethyl cellulose containing phenol groups, namely the modified carboxymethyl cellulose.
The preparation method of the plant extract comprises the following steps:
weighing 100g of fructus forsythiae, 150g of herba violae, 80g of tripterygium wilfordii, 100g of white jili, 250g of rose and 150g of citronella, uniformly mixing, grinding, adding into 1L of 60% ethanol solution, soaking for 8 hours at room temperature, extracting by ultrasonic waves at 45 ℃ for 25min, and filtering to obtain a first extract and filter residues; adding 1L of 70% ethanol solution into the filter residue, carrying out reflux extraction at 80 ℃ for 5 hours, and filtering after extraction to obtain a second extract; combining the first extract with the second extract, concentrating under reduced pressure, and recovering ethanol to obtain the plant extract.
The preparation method of the modified negative ion powder comprises the following steps:
s1, adding 100g of negative ion powder into 500mL of absolute ethyl alcohol after washing and sterilizing treatment, soaking for 3 hours, then adding 2g of KH550, putting into a ball milling tank at room temperature for ball milling at the ball milling speed of 2500r/min for 2 hours, and drying after ball milling to obtain surface modified negative ion powder;
s2, adding the surface modified anion powder obtained in the step S1 into deionized water, adding 500mL of dopamine hydrochloride of 6g/L under stirring for soaking for 30min, then adding trihydroxy aminomethane to adjust the pH to 9.5, carrying out light-proof reaction at the reaction temperature of 30 ℃ for 8h, and washing and drying after the reaction is completed to obtain the modified anion powder.
Example 3
A method of preparing the skin care dressing comprising the steps of:
(1) Adding 700g of sodium alginate, 70g of aloe juice, 60g of honey, 40g of glycerol and 50-100g of plant extract into 2L of deionized water, uniformly stirring, then adding 30-60g of modified anion powder, and reacting for 3 hours at 60 ℃ under the stirring condition, thus obtaining a mixture after the reaction is completed;
(2) Adding 100g of hyaluronic acid and 50g of modified carboxymethyl cellulose into the mixture in the step (1), stirring at 50 ℃ for reaction for 2 hours, placing at 5 ℃ for 10 hours after the reaction is finished, and then sterilizing to obtain the skin care dressing.
The preparation method of the modified carboxymethyl cellulose comprises the following steps:
(a) Adding 100g of carboxymethyl cellulose into 500mL of deionized water, stirring and dissolving, then adding 15g N-hydroxysuccinimide, heating and reacting at 70 ℃ for 3 hours, and concentrating under reduced pressure and drying after the reaction is completed to obtain activated carboxymethyl cellulose;
(b) Adding 100g of activated carboxymethyl cellulose obtained in the step (a) into 500mL of 80% ethanol solution, then adding 30g of p-hydroxyphenylethylamine, stirring for reaction at the reaction temperature of 80 ℃ for 4 hours, concentrating and drying after the reaction is completed to obtain carboxymethyl cellulose containing phenol groups, namely the modified carboxymethyl cellulose.
The preparation method of the plant extract comprises the following steps:
weighing 100g of fructus forsythiae, 200g of herba violae, 100g of tripterygium wilfordii, 150g of white jili, 300g of rose and 200g of citronella, uniformly mixing, grinding, adding into 1L of 60% ethanol solution, soaking for 10 hours at room temperature, extracting by ultrasonic waves at 50 ℃ for 20 minutes, and filtering to obtain a first extract and filter residues; adding 1L of 70% ethanol solution into the filter residue, carrying out reflux extraction at 85 ℃ for 3 hours, and filtering after extraction to obtain a second extract; combining the first extract with the second extract, concentrating under reduced pressure, and recovering ethanol to obtain the plant extract.
The preparation method of the modified negative ion powder comprises the following steps:
s1, adding 100g of negative ion powder into 500mL of absolute ethyl alcohol after washing and sterilizing treatment, soaking for 4 hours, then adding 3g of KH550, putting into a ball milling tank at room temperature for ball milling at the speed of 3000r/min for 1 hour, and drying after ball milling to obtain surface modified negative ion powder;
s2, adding the surface modified anion powder obtained in the step S1 into deionized water, adding 500mL and 8g/L dopamine hydrochloride under stirring for soaking for 20min, then adding trihydroxy aminomethane to adjust the pH to 9.5, carrying out light-proof reaction at 35 ℃ for 6h, and washing and drying after the reaction is completed to obtain the modified anion powder.
Comparative example 1
A method of preparing the skin care dressing comprising the steps of:
(1) Adding 500g of sodium alginate, 30g of aloe juice, 20g of honey, 20g of glycerol and 50g of plant extract into 2L of deionized water, uniformly stirring, then adding 30g of modified anion powder, and carrying out heat preservation reaction for 7h at 40 ℃ under the stirring condition, thus obtaining a mixture after the reaction is completed;
(2) Adding 50g of hyaluronic acid and 30g of carboxymethyl cellulose into the mixture in the step (1), stirring and reacting for 5 hours at 40 ℃, placing at 0 ℃ for 6 hours after the reaction is finished, and then sterilizing to obtain the skin care dressing.
The preparation method of the plant extract comprises the following steps:
weighing 100g of fructus forsythiae, 100g of herba violae, 50g of tripterygium wilfordii, 50g of white jili, 200g of rose and 100g of citronella, uniformly mixing, grinding, adding into 1L of 60% ethanol solution, soaking for 6 hours at room temperature, extracting by ultrasonic waves at 40 ℃ for 30min, and filtering to obtain a first extract and filter residues; adding 1L of 70% ethanol solution into the filter residue, carrying out reflux extraction at 75 ℃ for 6 hours, and filtering after extraction to obtain a second extract; combining the first extract with the second extract, concentrating under reduced pressure, and recovering ethanol to obtain the plant extract.
The preparation method of the modified negative ion powder comprises the following steps:
s1, adding 100g of negative ion powder into 500mL of absolute ethyl alcohol after washing and sterilizing treatment, soaking for 2 hours, then adding 1g of KH550, putting into a ball milling tank at room temperature for ball milling at the speed of 2000r/min for 3 hours, and drying after ball milling to obtain surface modified negative ion powder;
s2, adding the surface modified anion powder obtained in the step S1 into deionized water, adding 500mL of 4g/L dopamine hydrochloride under stirring for soaking for 20min, then adding trihydroxy aminomethane to adjust the pH to 9.5, carrying out light-proof reaction at the reaction temperature of 25 ℃ for 10h, and washing and drying after the reaction is completed to obtain the modified anion powder.
Comparative example 2
A method of preparing the skin care dressing comprising the steps of:
(1) Adding 500g of sodium alginate, 30g of aloe juice, 20g of honey and 20g of glycerol into 2L of deionized water, uniformly stirring, then adding 30g of modified anion powder, and carrying out heat preservation reaction for 7h at 40 ℃ under the stirring condition to obtain a mixture after the reaction is completed;
(2) Adding 50g of hyaluronic acid and 30g of modified carboxymethyl cellulose into the mixture in the step (1), stirring at 40 ℃ for reaction for 5 hours, placing at 0 ℃ for 6 hours after the reaction is finished, and then sterilizing to obtain the skin care dressing.
The preparation method of the modified carboxymethyl cellulose comprises the following steps:
(a) Adding 100g of carboxymethyl cellulose into 500mL of deionized water, stirring for dissolution, then adding 5g of N-hydroxysuccinimide, heating for reaction at 50 ℃ for 5 hours, and concentrating under reduced pressure and drying after the reaction is completed to obtain activated carboxymethyl cellulose;
(b) Adding 100g of activated carboxymethyl cellulose obtained in the step (a) into 500mL of 80% ethanol solution, then adding 20g of p-hydroxyphenylethylamine, stirring for reaction at 70 ℃ for 8 hours, concentrating and drying after the reaction is completed to obtain carboxymethyl cellulose containing phenol groups, namely the modified carboxymethyl cellulose.
The preparation method of the modified negative ion powder comprises the following steps:
s1, adding 100g of negative ion powder into 500mL of absolute ethyl alcohol after washing and sterilizing treatment, soaking for 2 hours, then adding 1g of KH550, putting into a ball milling tank at room temperature for ball milling at the speed of 2000r/min for 3 hours, and drying after ball milling to obtain surface modified negative ion powder;
s2, adding the surface modified anion powder obtained in the step S1 into deionized water, adding 500mL of 4g/L dopamine hydrochloride under stirring for soaking for 20min, then adding trihydroxy aminomethane to adjust the pH to 9.5, carrying out light-proof reaction at the reaction temperature of 25 ℃ for 10h, and washing and drying after the reaction is completed to obtain the modified anion powder.
Comparative example 3
A method of preparing the skin care dressing comprising the steps of:
(1) Adding 500g of sodium alginate, 30g of aloe juice, 20g of honey, 20g of glycerol and 50g of plant extract into 2L of deionized water, uniformly stirring, then adding 30g of anion powder, and reacting for 7h at 40 ℃ under the stirring condition, thus obtaining a mixture after the reaction is completed;
(2) Adding 50g of hyaluronic acid and 30g of modified carboxymethyl cellulose into the mixture in the step (1), stirring at 40 ℃ for reaction for 5 hours, placing at 0 ℃ for 6 hours after the reaction is finished, and then sterilizing to obtain the skin care dressing.
The preparation method of the modified carboxymethyl cellulose comprises the following steps:
(a) Adding 100g of carboxymethyl cellulose into 500mL of deionized water, stirring for dissolution, then adding 5g of N-hydroxysuccinimide, heating for reaction at 50 ℃ for 5 hours, and concentrating under reduced pressure and drying after the reaction is completed to obtain activated carboxymethyl cellulose;
(b) Adding 100g of activated carboxymethyl cellulose obtained in the step (a) into 500mL of 80% ethanol solution, then adding 20g of p-hydroxyphenylethylamine, stirring for reaction at 70 ℃ for 8 hours, concentrating and drying after the reaction is completed to obtain carboxymethyl cellulose containing phenol groups, namely the modified carboxymethyl cellulose.
The preparation method of the plant extract comprises the following steps:
weighing 100g of fructus forsythiae, 100g of herba violae, 50g of tripterygium wilfordii, 50g of white jili, 200g of rose and 100g of citronella, uniformly mixing, grinding, adding into 1L of 60% ethanol solution, soaking for 6 hours at room temperature, extracting by ultrasonic waves at 40 ℃ for 30min, and filtering to obtain a first extract and filter residues; adding 1L of 70% ethanol solution into the filter residue, carrying out reflux extraction at 75 ℃ for 6 hours, and filtering after extraction to obtain a second extract; combining the first extract with the second extract, concentrating under reduced pressure, and recovering ethanol to obtain the plant extract.
The skin care dressings prepared in examples 1 to 3 and comparative examples 1 to 3 were subjected to wound healing performance test, specifically as follows:
mice (male, 12-13 weeks, 90-100 g) were used as experimental animals, and the observation points were 3, 7, 14, and 21d after injury, 10 animals at each phase point. The back of the rat is dehaired by 8% sodium sulfide solution, sodium pentobarbital is administered to the back of the rat through the abdominal cavity after 24 hours, the rat is scalded by 80 ℃ water bath for 15 seconds after the anesthesia is successful, 10% deep II skin of the back of the rat is scalded (confirmed by a disease detection section), and 5ml physiological saline is administered to the back of the rat through the abdominal cavity after the injury. The skin care dressings obtained in examples 1 to 3 and comparative examples 1 to 3 were respectively applied to the wound surface, and the wound surface healing rate was calculated at each sampling time point by the following method: firstly, the wound surface is traced on semitransparent paper, then the paper is used as a template, hard paper sheets with uniform texture are sheared into the same size, and then the size of the wound surface is indirectly represented by the weight of the hard paper sheets by weighing a balance. The wound healing rate was calculated as follows: wound healing rate (%) = (original wound area-unhealed wound area)/original wound area. Pathological examination, knowing the wound healing quality, and determining the healing time according to the wound healing condition. The test results are shown in Table 1 below:
table 1: wound healing Properties of the skin care dressings obtained in examples 1 to 3 and comparative examples 1 to 3
As can be seen from table 1 above, the skin care dressing prepared by the application shortens the healing time of the skin wound surface, can quickly stop bleeding of the skin wound, provides a good environment for wound surface repair of skin tissues, achieves better effect of helping skin recover, and reduces the healing time of the wound surface wound; in comparative example 1, since carboxymethyl cellulose is not modified, the crosslinking degree of the carboxymethyl cellulose and sodium alginate is limited, and substances such as coated plant extract with anti-inflammatory and bactericidal functions are less, and the healing time is prolonged; in comparative example 2, no plant extract is added, the dressing treatment effect is reduced, and the healing time is prolonged; in comparative example 3, negative ions were not modified, probably because the compatibility of the negative ion powder with sodium alginate and carboxymethyl cellulose was poor, and the negative ions were easily dropped off during the preparation process, resulting in a decrease in the amount of negative ions released and an increase in the healing time.
The skin care dressings prepared in examples 1 to 3 and comparative examples 1 to 3 were subjected to antibacterial property test: according to the bacteriostasis efficacy measurement of the 2015 edition Chinese pharmacopoeia bacteriostasis efficacy examination method, the number of the bacterial colonies which survive for 48 hours in the test liquid of the vitis shasii liquid culture medium is measured, and the test bacteria are: the bacteriostasis rates of staphylococcus aureus, candida albicans, escherichia coli, examples 1-3 and comparative examples 1-3 are shown in table 2 below:
table 2 results of antibacterial performance test of skin care dressings of examples 1 to 3 and comparative examples 1 to 3
As can be seen from table 2 above, the skin care dressing prepared by the invention has a bacteriostasis rate of more than 99% on staphylococcus aureus, candida albicans and escherichia coli within 48 hours, and has a good bacteriostasis effect and a long bacteriostasis time, while in comparative example 1, the carboxymethyl cellulose is not modified, the crosslinking degree of the carboxymethyl cellulose and sodium alginate is limited, and the coated plant extract with anti-inflammatory and bactericidal functions has fewer substances and obviously reduced bacteriostasis effect; in comparative example 2, the bacteriostatic effect was further reduced without adding the plant extract.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The skin care dressing is characterized by being prepared from the following raw materials in parts by weight:
50-70 parts of sodium alginate, 5-10 parts of hyaluronic acid, 3-7 parts of aloe juice, 2-6 parts of honey, 30-50 parts of modified carboxymethyl cellulose, 2-4 parts of glycerol, 5-10 parts of plant extract, 3-6 parts of modified anion powder and 200 parts of deionized water;
the preparation method of the modified carboxymethyl cellulose comprises the following steps:
(a) Adding carboxymethyl cellulose into deionized water, stirring for dissolution, then adding N-hydroxysuccinimide, heating for reaction, concentrating under reduced pressure after the reaction is finished, and drying to obtain activated carboxymethyl cellulose;
(b) Adding the activated carboxymethyl cellulose obtained in the step (a) into an 80% ethanol solution, then adding p-hydroxyphenylethylamine, stirring for reaction, concentrating and drying after the reaction is finished to obtain carboxymethyl cellulose containing phenol groups, namely the modified carboxymethyl cellulose;
the preparation method of the plant extract comprises the following steps:
weighing fructus forsythiae, herba Violae, radix Tripterygii Wilfordii, fructus Piperis Longi, flos Rosae Rugosae and herba Cymbopogonis Citrari, mixing, grinding, adding into 60% ethanol solution, soaking at room temperature for 6-10 hr, ultrasonic extracting, and filtering to obtain first extractive solution and residue; adding 70% ethanol solution into the filter residue, performing reflux extraction, and filtering after extraction to obtain a second extract; combining the first extract with the second extract, concentrating under reduced pressure, and recovering ethanol to obtain the plant extract;
the preparation method of the modified negative ion powder comprises the following steps:
s1, washing and sterilizing anion powder, adding the anion powder into absolute ethyl alcohol, soaking for 2-4 hours, then adding KH550, putting the powder into a ball milling tank at room temperature for ball milling, and drying after ball milling is finished to obtain surface modified anion powder;
s2, adding the surface modified anion powder obtained in the step S1 into deionized water, adding dopamine hydrochloride under stirring for soaking for 20-40min, then adding trihydroxy aminomethane to adjust the pH to 9.5, carrying out a light-shielding reaction, and washing and drying after the reaction is completed to obtain modified anion powder;
the skin care dressing is prepared by the following steps:
(1) Adding sodium alginate, aloe juice, honey, glycerol and plant extract into deionized water according to a certain proportion, uniformly stirring, then adding modified anion powder, and carrying out heat preservation reaction under the stirring condition to obtain a mixture after the reaction is completed;
(2) Adding hyaluronic acid and modified carboxymethyl cellulose into the mixture obtained in the step (1), stirring for reaction, placing at 0-5 ℃ for 6-10h after the reaction is completed, and then sterilizing to obtain the skin care dressing.
2. A skin care dressing according to claim 1, wherein the mass ratio of carboxymethyl cellulose to N-hydroxysuccinimide in step (a) is 100:5-15; the heating reaction temperature is 50-70 ℃ and the reaction time is 3-5h.
3. A skin care dressing according to claim 1, wherein the mass ratio of activated carboxymethyl cellulose to p-hydroxyphenylethylamine in step (b) is 100:20-30 parts; the stirring reaction temperature is 70-80 ℃ and the reaction time is 4-8h.
4. The skin care dressing according to claim 1, wherein the mass ratio of fructus forsythiae, herba violae, radix tripterygii, white atractylodes rhizome, rose and citronella is 1:1-2:0.5-1:0.5-1.5:2-3:1-2; the ultrasonic extraction temperature is 40-50deg.C, and the extraction time is 20-30min; the reflux extraction temperature is 75-85 ℃, and the extraction time is 3-6h.
5. The skin care dressing according to claim 1, wherein the mass ratio of the negative ion powder to KH550 in step S1 is 100:1-3, wherein the ball milling rotating speed is 2000-3000r/min, and the ball milling time is 1-3h; in the step S2, the addition amount of the dopamine hydrochloride is 4-8g/L, the light-shielding reaction temperature is 25-35 ℃, and the reaction time is 6-10h.
6. A method of preparing a skin care dressing according to any one of claims 1 to 5, comprising the steps of:
(1) Adding sodium alginate, aloe juice, honey, glycerol and plant extract into deionized water according to a certain proportion, uniformly stirring, then adding modified anion powder, and carrying out heat preservation reaction under the stirring condition to obtain a mixture after the reaction is completed;
(2) Adding hyaluronic acid and modified carboxymethyl cellulose into the mixture obtained in the step (1), stirring for reaction, placing at 0-5 ℃ for 6-10h after the reaction is completed, and then sterilizing to obtain the skin care dressing.
7. The preparation method according to claim 6, wherein the reaction temperature in the step (1) is 40-60 ℃ and the reaction time is 3-7h; in the step (2), the stirring reaction temperature is 40-50 ℃ and the reaction time is 2-5h.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102702833A (en) * | 2012-01-12 | 2012-10-03 | 上海韬鸿化工科技有限公司 | Anion powder |
| CN103520764A (en) * | 2013-10-29 | 2014-01-22 | 成都迪康中科生物医学材料有限公司 | Functional dressing, and preparation method and application thereof |
| CN109045349A (en) * | 2018-09-27 | 2018-12-21 | 四川省原子能研究院 | A kind of hydrogel skin wound dressing and preparation method thereof that antibacterial heal-promoting closes |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102702833A (en) * | 2012-01-12 | 2012-10-03 | 上海韬鸿化工科技有限公司 | Anion powder |
| CN103520764A (en) * | 2013-10-29 | 2014-01-22 | 成都迪康中科生物医学材料有限公司 | Functional dressing, and preparation method and application thereof |
| CN109045349A (en) * | 2018-09-27 | 2018-12-21 | 四川省原子能研究院 | A kind of hydrogel skin wound dressing and preparation method thereof that antibacterial heal-promoting closes |
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| 高春梅等.海藻酸钠水凝胶的制备及其在药物释放中的应用.《化学进展》.2013,第第25卷卷(第第25卷期),第1013页"引言"部分、第1016-1017页"2. 3 酶交联"部分. * |
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