CN108478848A - A kind of antibiotic property medical hemostatic degreasing cotton gauze and preparation method thereof - Google Patents
A kind of antibiotic property medical hemostatic degreasing cotton gauze and preparation method thereof Download PDFInfo
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- CN108478848A CN108478848A CN201810344853.5A CN201810344853A CN108478848A CN 108478848 A CN108478848 A CN 108478848A CN 201810344853 A CN201810344853 A CN 201810344853A CN 108478848 A CN108478848 A CN 108478848A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
Abstract
The present invention provides a kind of antibiotic property medical hemostatic degreasing cotton gauze, the antibiotic property medical hemostatic degreasing cotton gauze is made of drug application and the tissue substance of medicament-carried application, and the drug application is made of Chinese medicine and Western medicine；The tissue substance of the medicament-carried application is by ancient gastral cavity azelon and cotton fiber is blended forms；The present invention integrates hemostasis and antibacterial action, not only to the abnormal bleeding of the operations such as lung, liver, pancreas, adrenal gland, except obstetrics and postpartum haemorrhage, uropoiesis gastrointestinal hemorrhage etc. are with significant effect, and it is used compared with depth and the big situation of amount of bleeding wound is larger, hemostasis is rapid, it is also beneficial to the recovery of wound, has a broad antifungal spectrum, sterilizing power are strong simultaneously, effect is rapid, also effective to including Pseudomonas aeruginosa, Klebsiella, Escherichia coli, Enterobacter, staphylococcus, Mycoplasma and Chlamydia.In addition, having good effect to synergistic sulfonamide drug-fast bacteria, Penicillin-resistant Staphylococcus aureus and tylosin or Tiamulin drug resistance mycoplasma.
Description
Technical field
The present invention relates to medical material tech fields, specifically, the present invention relates to a kind of antibiotic property medical hemostatic degreasings
Cotton gauze and preparation method thereof.
Background technology
Currently, China's textile consumer need enjoys type consumption by living type consumption steering, gradually from textile production
Base becomes main body of consumption, and people are growing day by day for the demand of high-quality textile, to high quality fiber especially to human body
The demand of protein fibre with good affinity is equally being continuously increased.Common tradition natural protein fibre includes hair
Suede class and silk fiber.This two types of fibers with comfort the outstanding application performance such as good, good luster, elegant style and disappeared
The favor of the person of expense, but its resource is limited, price is high, and 3.5% or so is only accounted in global textile fabric total quantity consumed.Therefore, people
The research and development of azlon have been begun to very early.Currently, including soybean fiber and milk protein fiber etc.
Inside realized that the azlon of industrialization is not 100% soybean protein regenerated fiber or milk protein
Regenerated fiber, wherein containing about 55~75% synthetic high polymer, these fibers are difficult to meet high-end textile for fiber quality
Requirement.
Gauze is the necessity in our daily lifes, then selective add Chinese medicine material in gauze process
It is mixed with organic cotton, protein fibre, bamboo fibre, anti-biotic material, jade powder, existing gauze can be made not only with clean
Net work can also have improvement blood circulation outside, boost metabolism, dispelling fatigue, inducing resuscitation brain tonic, the effect of light speckles, beautification and white, and make
The gauze feel obtained is smooth, submissive pleasant, and moisture absorption is ventilative, more comfort, but can usually suffer from a problem that problem is bacterium
Infection, bacterium infection not only can delayed healing process, the problems such as causing wound inflammation, even can be to the life of patient when situation is serious
Life safety threatens, therefore prepares it is a kind of have both biocompatibility, Biofunctional be especially with antibiotic property it is medical stop
Blood material has important research significance.
China is the first ancestor of Chinese medicine, with a long history, and medicinal raw material type is abundant, and scope of selecting material is vast, and because of Chinese medicine safety
Nonirritant, toxic side effect has a extensive future outside Chinese and Western, but slowly effect, and Western medicine is although quick, but expensive, therefore combines
Chinese and Western medicine uses the combination for preparing material with gauze that there is good foreground, the level of consumption to be also more easy in the common people really
Receive.
Invention content
To solve the above problems, the present invention provides a kind of antibiotic property medical hemostatic degreasing cotton gauze, can quick-acting haemostatic powder,
And antibiotic property is strong, is made of drug application and the tissue substance of medicament-carried application, the drug application is by Chinese medicine and Western medicine group
At；The tissue substance of the medicament-carried application is by ancient gastral cavity azelon and cotton fiber is blended forms.
A kind of antibiotic property medical hemostatic degreasing cotton gauze, the raw material composition and parts by weight that the traditional Chinese medicine ingredients are made are：
55-85 parts of folium callicarpae pedunculatae, 53-83 parts of Radix Notoginseng, 51-81 parts of madder, 48-78 parts of Swertia vacillana (Hance) Maxim., 43-73 parts of cannalike dona rhizome, emblic leafflower leaf 40-70
Part；The raw material that the western medicine composition is made forms and parts by weight are：0.5-1.7 parts of menadione sodium bisulfite, etamsylate
0.2-1.6 parts, to 0.1-1.5 parts of carboxyl Bian amine, the weight proportion of the Gu gastral cavity azelon and cotton fiber is 1-2:8-10.
Further, the raw material that the traditional Chinese medicine ingredients are made forms and parts by weight are：75 parts of folium callicarpae pedunculatae, 69 parts of Radix Notoginseng,
65 parts of madder, 64 parts of Swertia vacillana (Hance) Maxim., 58 parts of cannalike dona rhizome, 55 parts of emblic leafflower leaf；The raw material composition and parts by weight of the western medicine composition is made
Number is：1.1 parts of menadione sodium bisulfite, 0.9 part of etamsylate, to 0.8 part of carboxyl Bian amine, the Gu gastral cavity azelon and cotton
The weight proportion of fiber is 1.5:9.
The method of the antibiotic property medical hemostatic degreasing cotton gauze includes the following steps：
（1）, folium callicarpae pedunculatae and emblic leafflower leaf removed into impurity, dry, weed out grey bits, be placed in mortar and grind 40-100min, obtained
200 targeted fine powders, be eventually adding 50-80wt% ethyl alcohol and ethyl acetate extraction 5- hydroxyls -4 ', 3,6,7- tetramethoxies-Huang
Ketone, amlaic acid, Lupeol, cupreol, gallic acid and 3,6- digalloylglucoses obtain extract, spare；
（2）, Radix Notoginseng, Swertia vacillana (Hance) Maxim. and cannalike dona rhizome decocted 2-3 times in distilled water, it is 1-3 hours each, merge decoction liquor, filtering,
50wt% ethyl alcohol is added, refrigerates 10-12 hours, filtering and concentrating is spare at medicinal extract；
（3）, madder removed into stem seedling, remove soil and thin fibrous root, take madder piece, set that fry in pot to appearance be in coke black, it is internal
Strong yellow sprays clear water, cools, be placed in mortar and grind 60-120min, obtained 200 targeted fine powders, and passed through benzene and n-hexane
Extract madder color, oleanolic acid acetic acid esters, oleanolic aldehyde acetic acid esters, madder terpene triol, purpurin, purpuroxanthin, two
Hydrogen rubimaillin, 1- hydroxyl -2- carboxyl -3- methoxyl groups fear quinone, 2'- methoxyl group rubimaillins, obtain extract, spare；
（4）, by menadione sodium bisulfite, etamsylate and to carboxyl Bian amine ultrasonic grinding, cross 220 targeted fine powders, it is spare；
（5）, by step（1）And step（3）Glycerine is added in obtained extract, continuously adds step（2）Obtained medicinal extract, finally
Deionized water and step is added（4）Obtained fine powder, filtering, obtains filtrate；
（6）, the tissue substance of medicament-carried application immersed in hot water storgae, first use 97-100 DEG C of water stirring and washing 40-80min,
After be cooled to 5-10 DEG C, step step is added in stirring and washing 10-20 minutes（5）Obtained filtrate adjusts temperature, at 60-80 DEG C
Lower continuation stirring and washing 40-80min continues to be heated to 97-100 DEG C and keeps 20min in addition softening agent with polyacrylamide,
The tissue substance of medicament-carried application is taken out, dewaterer is dehydrated 30min；
（7）, by step（6）In dewatered medicament-carried application tissue substance through Co radiation sterilization, drying is to get to described
Antibiotic property medical hemostatic degreasing cotton gauze.
Further, the step（6）The rotating speed of middle stirring and washing is 120-160r/min.
Further, the step（6）In softening agent be fatty diglycollic amide, double octadecylsuccinic acid sulfonic acid
Salt or pentaerythritol fatty ester.
Radix Notoginseng in the present invention contains arasaponin, and arasaponin can inhibit platelet aggregation, not only have cardiac stimulant,
Decompression, liver protection, anti-inflammatory, reduction blood cholesterol, immunological regulation and antivirus action are even more to have only to blood and hemopoietic system
The effects that blood, platelet aggregation-against and thrombolysis, haemolysis, hematopoiesis；Have anti-arrhythmia, anti-atherogenic hard cardiovascular system
The effects that change, resist oxygen lack and Hemorrhagic shock, improvement cerebral ischemia, can also enhance immune function, and liver function protecting is antitumor, delays to decline
Always, hypoglycemic, anti-inflammatory, Auto-regulator metabolism promotes growth, long-term administration is substantially without side reaction.
Folium callicarpae pedunculatae in the present invention has astringing to arrest bleeding, clearing heat and detoxicating effect, belongs to astringent hemostatic, interior to contain 30
Five alkane（Ⅰ）, α-amyrin, 5- hydroxyls -4 ', 3,6,7- tetramethoxies-flavones（Ⅳ）Deng can have to fibrinolytic system aobvious
The inhibiting effect of work can increase blood platelet, shorten bleeding, factor, clot retration time, to Escherichia coli, flexner's dysentery
Bacillus, staphylococcus aureus, streptococcus etc. have inhibiting effect.
Containing purple alizarin, madder color, oleanolic acid acetic acid esters, oleanolic aldehyde acetic acid esters, madder in madder in the present invention
Terpene triol, purpurin, rubican, purpuroxanthin, Dihydromollugin, 1- hydroxyl -2- carboxyl -3- methoxyl groups fear quinone,
The ingredients such as 2'- methoxyl groups rubimaillin, rubimaillin have and shorten bleeding time, platelet aggregation-against, increasing leukocyte
Effect；With kobadrin, antibacterial, antitumaous effect, the blood coagulation time of rabbit can be shortened, to golden yellow and white grapes
Coccus, pneumococcus and Bacillus influenzae etc. have certain inhibiting effect.
It is also added into Swertia vacillana (Hance) Maxim., cannalike dona rhizome, emblic leafflower leaf in the present invention, all has the effect of sterilizing, additionally adds
Menadione sodium bisulfite, etamsylate are entered and to carboxyl Bian amine, the menadione sodium bisulfite, etamsylate and to carboxylic
The structural formula of base Bian amine is respectively as follows（1）Formula,（2）Formula,（3）Formula：
Menadione sodium bisulfite, etamsylate and to carboxyl Bian amine have effects that promote coagulation factor synthesis, have anti-fiber
Protein dissolution acts on, and can increase the quantity of blood platelet, enhance its aggregation and adhesiveness, promote intra platelet free calcium blood coagulation activity
Substance shortens the clotting time, accelerates clot contraction, reduces the permeability of capillary, reduces blood exudation.
Compared with prior art, the present invention especially outstanding be：
1, the present invention integrates hemostasis and antibacterial action, not only the abnormal bleeding to operations such as lung, liver, pancreas, adrenal gland, uropoiesis
Gastrointestinal hemorrhage etc. has a significant effect, and larger to wound can be used compared with depth and the big situation of amount of bleeding, and hemostasis is rapid,
Be conducive to the recovery of wound, while has a broad antifungal spectrum, sterilizing power are strong, effect is rapid, to including Pseudomonas aeruginosa, citric acid
Bacterium, Escherichia coli, Enterobacter, staphylococcus, Mycoplasma and Chlamydia are also effective.In addition, to synergistic sulfonamide drug-fast bacteria, celebrating
Big mycin drug-resistant pseudomonas aeruginosa, Penicillin-resistant Staphylococcus aureus and tylosin or Tiamulin drug resistance mycoplasma have good
Good effect.
2, the antibiotic property that the present invention is prepared by way of being combined with hemostasis, the Chinese medicine of antibacterial action, Western medicine is medical only
Blood degreasing cotton gauze is prepared simply, and Chinese and Western combines the drawbacks of not only increasing only Chinese medicine slowly effect, also reduces only Western medicine
Expensive disadvantage, therefore the combination for combining Chinese and Western medicine that the tissue substance with medicament-carried application is used to prepare material has
Good foreground.
3, antibiotic property medical hemostatic degreasing cotton gauze of the present invention is by ancient gastral cavity azelon and cotton fiber is blended forms, not only
The performance of its stretching mechanical is improved, and can accelerate ancient gastral cavity azelon that can degrade, good biocompatibility can be applied to
The fields such as the manufacture of high-quality textile and biology, medicine, organizational project.
Specific implementation mode
Present invention is further elaborated in following combination specific embodiment, and embodiment only helps understand the present invention, but not
Present disclosure can be limited, any restrictions of the scope of the invention are should not be construed as.
Embodiment 1
A kind of antibiotic property medical hemostatic degreasing cotton gauze, is made of drug application and the tissue substance of medicament-carried application, described
Drug application is made of Chinese medicine and Western medicine；The tissue substance of the medicament-carried application it is blended by ancient gastral cavity azelon and cotton fiber and
At.
The raw material that the traditional Chinese medicine ingredients are made forms and parts by weight are：75 parts of folium callicarpae pedunculatae, 69 parts of Radix Notoginseng, 65 parts of madder,
64 parts of Swertia vacillana (Hance) Maxim., 58 parts of cannalike dona rhizome, 55 parts of emblic leafflower leaf；The raw material that the western medicine composition is made forms and parts by weight are：Sulfurous
Sour 1.1 parts of hydrogen sodium menadione, 0.9 part of etamsylate, to 0.8 part of carboxyl Bian amine, the weight of Gu the gastral cavity azelon and cotton fiber
Amount proportioning is 1.5:9.
Antibiotic property medical hemostatic degreasing cotton gauze is prepared by said ratio：
（1）, folium callicarpae pedunculatae and emblic leafflower leaf removed into impurity, dry, weed out grey bits, be placed in mortar and grind 100min, obtained 200
Targeted fine powder, be eventually adding 50wt% ethyl alcohol and ethyl acetate extraction 5- hydroxyls -4 ', it is 3,6,7- tetramethoxies-flavones, remaining
Sweet son acid, Lupeol, cupreol, gallic acid and 3,6- digalloylglucoses obtain extract, spare；
（2）, Radix Notoginseng, Swertia vacillana (Hance) Maxim. and cannalike dona rhizome decoct to 3 times in distilled water, 3 hours every time, merge decoction liquor, filter, be added
50wt% ethyl alcohol refrigerates 11 hours, and filtering and concentrating is spare at medicinal extract；
（3）, madder removed into stem seedling, remove soil and thin fibrous root, take madder piece, set that fry in pot to appearance be in coke black, it is internal
Strong yellow sprays clear water, cools, be placed in mortar and grind 80min, obtained 200 targeted fine powders, is extracted by benzene and n-hexane
Madder color, oleanolic acid acetic acid esters, oleanolic aldehyde acetic acid esters, madder terpene triol, purpurin, purpuroxanthin, dihydro are big
Leaf rubican, 1- hydroxyl -2- carboxyl -3- methoxyl groups fear quinone, 2'- methoxyl group rubimaillins, obtain extract, spare；
（4）, by menadione sodium bisulfite, etamsylate and to carboxyl Bian amine ultrasonic grinding, cross 220 targeted fine powders, it is spare；
（5）, by step（1）And step（3）Glycerine is added in obtained extract, continuously adds step（2）Obtained medicinal extract, finally
Deionized water and step is added（4）Obtained fine powder, filtering, obtains filtrate；
（6）, the tissue substance of medicament-carried application immersed in hot water storgae, first use 100 DEG C of water stirring and washing 60min, stirring turn
Speed is 130r/min, after be cooled to 5 DEG C, stirring and washing 12min, step step is added（5）Obtained filtrate adjusts temperature,
Continue stirring and washing 75min, speed of agitator 135r/min at 70 DEG C, softening agent fatty diglycollic amide and poly- third is being added
Acrylamide continues to be heated to 98 DEG C and keeps 20min, takes out the tissue substance of medicament-carried application, and dewaterer is dehydrated 30min；
（7）, by step（6）In dewatered medicament-carried application tissue substance through Co radiation sterilization, drying is to get to described
Antibiotic property medical hemostatic degreasing cotton gauze.
Embodiment 2
A kind of antibiotic property medical hemostatic degreasing cotton gauze, is made of drug application and the tissue substance of medicament-carried application, described
Drug application is made of Chinese medicine and Western medicine；The tissue substance of the medicament-carried application it is blended by ancient gastral cavity azelon and cotton fiber and
At.
The raw material that the traditional Chinese medicine ingredients are made forms and parts by weight are：60 parts of folium callicarpae pedunculatae, 59 parts of Radix Notoginseng, 56 parts of madder,
53 parts of Swertia vacillana (Hance) Maxim., 48 parts of cannalike dona rhizome, 45 parts of emblic leafflower leaf；The raw material that the western medicine composition is made forms and parts by weight are：Sulfurous
Sour 0.8 part of hydrogen sodium menadione, 0.5 part of etamsylate, to 0.5 part of carboxyl Bian amine, the weight of Gu the gastral cavity azelon and cotton fiber
Amount proportioning is 1.8:10.
Antibiotic property medical hemostatic degreasing cotton gauze is prepared by said ratio：
（1）, folium callicarpae pedunculatae and emblic leafflower leaf removed into impurity, dry, weed out grey bits, be placed in mortar and grind 95min, obtained 200
Targeted fine powder, be eventually adding 50wt% ethyl alcohol and ethyl acetate extraction 5- hydroxyls -4 ', it is 3,6,7- tetramethoxies-flavones, remaining
Sweet son acid, Lupeol, cupreol, gallic acid and 3,6- digalloylglucoses obtain extract, spare；
（2）, Radix Notoginseng, Swertia vacillana (Hance) Maxim. and cannalike dona rhizome decoct to 2 times in distilled water, 2.5 hours every time, merge decoction liquor, filtering adds
Enter 50wt% ethyl alcohol, refrigerates 11 hours, filtering and concentrating is spare at medicinal extract；
（3）, madder removed into stem seedling, remove soil and thin fibrous root, take madder piece, set that fry in pot to appearance be in coke black, it is internal
Strong yellow sprays clear water, cools, be placed in mortar and grind 100min, obtained 200 targeted fine powders, and carried by benzene and n-hexane
Take madder color, oleanolic acid acetic acid esters, oleanolic aldehyde acetic acid esters, madder terpene triol, purpurin, purpuroxanthin, dihydro
Rubimaillin, 1- hydroxyl -2- carboxyl -3- methoxyl groups fear quinone, 2'- methoxyl group rubimaillins, obtain extract, spare；
（4）, by menadione sodium bisulfite, etamsylate and to carboxyl Bian amine ultrasonic grinding, cross 220 targeted fine powders, it is spare；
（5）, by step（1）And step（3）Glycerine is added in obtained extract, continuously adds step（2）Obtained medicinal extract, finally
Deionized water and step is added（4）Obtained fine powder, filtering, obtains filtrate；
（6）, the tissue substance of medicament-carried application immersed in hot water storgae, first use 97 DEG C of water stirring and washing 40-80min, stir
Rotating speed is 135r/min, after be cooled to 6 DEG C, stirring and washing 18min, step step is added（5）Obtained filtrate adjusts temperature,
Continue stirring and washing 70min, speed of agitator 135r/min at 78 DEG C, softening agent fatty diglycollic amide is being added and is gathering
Acrylamide continues to be heated to 98 DEG C and keeps 20min, takes out the tissue substance of medicament-carried application, and dewaterer is dehydrated 30min；
（7）, by step（6）In dewatered medicament-carried application tissue substance through Co radiation sterilization, drying is to get to described
Antibiotic property medical hemostatic degreasing cotton gauze.
Embodiment 3
A kind of antibiotic property medical hemostatic degreasing cotton gauze, is made of drug application and the tissue substance of medicament-carried application, described
Drug application is made of Chinese medicine and Western medicine；The tissue substance of the medicament-carried application it is blended by ancient gastral cavity azelon and cotton fiber and
At.
The raw material that the traditional Chinese medicine ingredients are made forms and parts by weight are：65 parts of folium callicarpae pedunculatae, 63 parts of Radix Notoginseng, 61 parts of madder,
58 parts of Swertia vacillana (Hance) Maxim., 53 parts of cannalike dona rhizome, 50 parts of emblic leafflower leaf；The raw material that the western medicine composition is made forms and parts by weight are：Sulfurous
Sour 1.6 parts of hydrogen sodium menadione, 1.5 parts of etamsylate, to 1.4 parts of carboxyl Bian amine, the weight of Gu the gastral cavity azelon and cotton fiber
Amount proportioning is 1:8.
Antibiotic property medical hemostatic degreasing cotton gauze is prepared by said ratio：
（1）, folium callicarpae pedunculatae and emblic leafflower leaf removed into impurity, dry, weed out grey bits, be placed in mortar and grind 90min, obtained 200
Targeted fine powder, be eventually adding 60wt% ethyl alcohol and ethyl acetate extraction 5- hydroxyls -4 ', it is 3,6,7- tetramethoxies-flavones, remaining
Sweet son acid, Lupeol, cupreol, gallic acid and 3,6- digalloylglucoses obtain extract, spare；
（2）, Radix Notoginseng, Swertia vacillana (Hance) Maxim. and cannalike dona rhizome decoct to 3 times in distilled water, 3 hours every time, merge decoction liquor, filter, be added
50wt% ethyl alcohol refrigerates 12 hours, and filtering and concentrating is spare at medicinal extract；
（3）, madder removed into stem seedling, remove soil and thin fibrous root, take madder piece, set that fry in pot to appearance be in coke black, it is internal
Strong yellow sprays clear water, cools, be placed in mortar and grind 110min, obtained 200 targeted fine powders, and carried by benzene and n-hexane
Take madder color, oleanolic acid acetic acid esters, oleanolic aldehyde acetic acid esters, madder terpene triol, purpurin, purpuroxanthin, dihydro
Rubimaillin, 1- hydroxyl -2- carboxyl -3- methoxyl groups fear quinone, 2'- methoxyl group rubimaillins, obtain extract, spare；
（4）, by menadione sodium bisulfite, etamsylate and to carboxyl Bian amine ultrasonic grinding, cross 220 targeted fine powders, it is spare；
（5）, by step（1）And step（3）Glycerine is added in obtained extract, continuously adds step（2）Obtained medicinal extract, finally
Deionized water and step is added（4）Obtained fine powder, filtering, obtains filtrate；
（6）, the tissue substance of medicament-carried application immersed in hot water storgae, first with 99 DEG C of water stirring and washing 80min, speed of agitator
For 130r/min, after be cooled to 8 DEG C, stirring and washing 20min, step step is added（5）Obtained filtrate adjusts temperature, 75
Continue stirring and washing 80min, speed of agitator 130r/min at DEG C, continues to be heated to 98 with polyacrylamide softening agent is added
DEG C and keep 20min, take out the tissue substance of medicament-carried application, dewaterer is dehydrated 30min；
（7）, by step（6）In dewatered medicament-carried application tissue substance through Co radiation sterilization, drying is to get to described
Antibiotic property medical hemostatic degreasing cotton gauze.
Comparative example 1
A kind of antibiotic property medical hemostatic degreasing cotton gauze, is made of drug application and the tissue substance of medicament-carried application, described
Drug application is made of Chinese medicine and Western medicine；The tissue substance of the medicament-carried application it is blended by ancient gastral cavity azelon and cotton fiber and
At.
The raw material that the traditional Chinese medicine ingredients are made forms and parts by weight are：30 parts of folium callicarpae pedunculatae, 50 parts of Radix Notoginseng, 10 parts of madder,
60 parts of Swertia vacillana (Hance) Maxim., 10 parts of cannalike dona rhizome, 15 parts of emblic leafflower leaf；The raw material that the western medicine composition is made forms and parts by weight are：Sulfurous
Sour 0.1 part of hydrogen sodium menadione, 0.1 part of etamsylate, to 0.2 part of carboxyl Bian amine, the weight of Gu the gastral cavity azelon and cotton fiber
Amount proportioning is 0.1:0.5.
Antibiotic property medical hemostatic degreasing cotton gauze is prepared by said ratio：
（1）, folium callicarpae pedunculatae and emblic leafflower leaf removed into impurity, dry, weed out grey bits, be placed in mortar and grind 100min, obtained 200
Targeted fine powder, be eventually adding 50wt% ethyl alcohol and ethyl acetate extraction 5- hydroxyls -4 ', it is 3,6,7- tetramethoxies-flavones, remaining
Sweet son acid, Lupeol, cupreol, gallic acid and 3,6- digalloylglucoses obtain extract, spare；
（2）, Radix Notoginseng, Swertia vacillana (Hance) Maxim. and cannalike dona rhizome decoct to 3 times in distilled water, 3 hours every time, merge decoction liquor, filter, be added
50wt% ethyl alcohol refrigerates 11 hours, and filtering and concentrating is spare at medicinal extract；
（3）, madder removed into stem seedling, remove soil and thin fibrous root, take madder piece, set that fry in pot to appearance be in coke black, it is internal
Strong yellow sprays clear water, cools, be placed in mortar and grind 80min, obtained 200 targeted fine powders, is extracted by benzene and n-hexane
Madder color, oleanolic acid acetic acid esters, oleanolic aldehyde acetic acid esters, madder terpene triol, purpurin, purpuroxanthin, dihydro are big
Leaf rubican, 1- hydroxyl -2- carboxyl -3- methoxyl groups fear quinone, 2'- methoxyl group rubimaillins, obtain extract, spare；
（4）, by menadione sodium bisulfite, etamsylate and to carboxyl Bian amine ultrasonic grinding, cross 220 targeted fine powders, it is spare；
（5）, by step（1）And step（3）Glycerine is added in obtained extract, continuously adds step（2）Obtained medicinal extract, finally
Deionized water and step is added（4）Obtained fine powder, filtering, obtains filtrate；
（6）, the tissue substance of medicament-carried application immersed in hot water storgae, first use 100 DEG C of water stirring and washing 60min, stirring turn
Speed is 130r/min, after be cooled to 5 DEG C, stirring and washing 12min, step step is added（5）Obtained filtrate adjusts temperature,
Continue stirring and washing 75min, speed of agitator 135r/min at 70 DEG C, softening agent fatty diglycollic amide and poly- third is being added
Acrylamide continues to be heated to 98 DEG C and keeps 20min, takes out the tissue substance of medicament-carried application, and dewaterer is dehydrated 30min；
（7）, by step（6）In dewatered medicament-carried application tissue substance through Co radiation sterilization, drying is to get to described
Antibiotic property medical hemostatic degreasing cotton gauze.
Comparative example 2
A kind of antibiotic property medical hemostatic degreasing cotton gauze, is made of drug application and the tissue substance of medicament-carried application, described
Drug application is made of Chinese medicine and Western medicine；The tissue substance of the medicament-carried application it is blended by ancient gastral cavity azelon and cotton fiber and
At.
The raw material that the traditional Chinese medicine ingredients are made forms and parts by weight are：2 parts of folium callicarpae pedunculatae, 52 parts of Radix Notoginseng, 7 parts of madder are green
Leaf is 48 parts red, 43 parts of cannalike dona rhizome, 7 parts of emblic leafflower leaf；The raw material that the western medicine composition is made forms and parts by weight are：Bisulfite
0.1 part of sodium menadione, 0.2 part of etamsylate, to 1.8 parts of carboxyl Bian amine, the weight of the Gu gastral cavity azelon and cotton fiber is matched
Than for 1-2:8-10.
Antibiotic property medical hemostatic degreasing cotton gauze is prepared by said ratio：
（1）, folium callicarpae pedunculatae and emblic leafflower leaf removed into impurity, dry, weed out grey bits, be placed in mortar and grind 95min, obtained 200
Targeted fine powder, be eventually adding 50wt% ethyl alcohol and ethyl acetate extraction 5- hydroxyls -4 ', it is 3,6,7- tetramethoxies-flavones, remaining
Sweet son acid, Lupeol, cupreol, gallic acid and 3,6- digalloylglucoses obtain extract, spare；
（2）, Radix Notoginseng, Swertia vacillana (Hance) Maxim. and cannalike dona rhizome decoct to 2 times in distilled water, 2.5 hours every time, merge decoction liquor, filtering adds
Enter 50wt% ethyl alcohol, refrigerates 11 hours, filtering and concentrating is spare at medicinal extract；
（3）, madder removed into stem seedling, remove soil and thin fibrous root, take madder piece, set that fry in pot to appearance be in coke black, it is internal
Strong yellow sprays clear water, cools, be placed in mortar and grind 100min, obtained 200 targeted fine powders, and carried by benzene and n-hexane
Take madder color, oleanolic acid acetic acid esters, oleanolic aldehyde acetic acid esters, madder terpene triol, purpurin, purpuroxanthin, dihydro
Rubimaillin, 1- hydroxyl -2- carboxyl -3- methoxyl groups fear quinone, 2'- methoxyl group rubimaillins, obtain extract, spare；
（4）, by menadione sodium bisulfite, etamsylate and to carboxyl Bian amine ultrasonic grinding, cross 220 targeted fine powders, it is spare；
（5）, by step（1）And step（3）Glycerine is added in obtained extract, continuously adds step（2）Obtained medicinal extract, finally
Deionized water and step is added（4）Obtained fine powder, filtering, obtains filtrate；
（6）, the tissue substance of medicament-carried application immersed in hot water storgae, first use 97 DEG C of water stirring and washing 40-80min, stir
Rotating speed is 135r/min, after be cooled to 6 DEG C, stirring and washing 18min, step step is added（5）Obtained filtrate adjusts temperature,
Continue stirring and washing 70min, speed of agitator 135r/min at 78 DEG C, softening agent fatty diglycollic amide is being added and is gathering
Acrylamide continues to be heated to 98 DEG C and keeps 20min, takes out the tissue substance of medicament-carried application, and dewaterer is dehydrated 30min；
（7）, by step（6）In dewatered medicament-carried application tissue substance through Co radiation sterilization, drying is to get to described
Antibiotic property medical hemostatic degreasing cotton gauze.
Comparative example 3
A kind of antibiotic property medical hemostatic degreasing cotton gauze, is made of drug application and the tissue substance of medicament-carried application, described
Drug application is made of Chinese medicine and Western medicine；The tissue substance of the medicament-carried application it is blended by ancient gastral cavity azelon and cotton fiber and
At.
The raw material that the traditional Chinese medicine ingredients are made forms and parts by weight are：10 parts of folium callicarpae pedunculatae, 2 parts of Radix Notoginseng, 50 parts of madder are green
Leaf is 20 parts red, 60 parts of cannalike dona rhizome, 10 parts of emblic leafflower leaf；The raw material that the western medicine composition is made forms and parts by weight are：Sulfurous acid
0.4 part of hydrogen sodium menadione, 0.2 part of etamsylate, to 1.6 parts of carboxyl Bian amine, the weight of Gu the gastral cavity azelon and cotton fiber
Proportioning is 0.7:5.
Antibiotic property medical hemostatic degreasing cotton gauze is prepared by said ratio：
（1）, folium callicarpae pedunculatae and emblic leafflower leaf removed into impurity, dry, weed out grey bits, be placed in mortar and grind 90min, obtained 200
Targeted fine powder, be eventually adding 60wt% ethyl alcohol and ethyl acetate extraction 5- hydroxyls -4 ', it is 3,6,7- tetramethoxies-flavones, remaining
Sweet son acid, Lupeol, cupreol, gallic acid and 3,6- digalloylglucoses obtain extract, spare；
（2）, Radix Notoginseng, Swertia vacillana (Hance) Maxim. and cannalike dona rhizome decoct to 3 times in distilled water, 3 hours every time, merge decoction liquor, filter, be added
50wt% ethyl alcohol refrigerates 12 hours, and filtering and concentrating is spare at medicinal extract；
（3）, madder removed into stem seedling, remove soil and thin fibrous root, take madder piece, set that fry in pot to appearance be in coke black, it is internal
Strong yellow sprays clear water, cools, be placed in mortar and grind 110min, obtained 200 targeted fine powders, and carried by benzene and n-hexane
Take madder color, oleanolic acid acetic acid esters, oleanolic aldehyde acetic acid esters, madder terpene triol, purpurin, purpuroxanthin, dihydro
Rubimaillin, 1- hydroxyl -2- carboxyl -3- methoxyl groups fear quinone, 2'- methoxyl group rubimaillins, obtain extract, spare；
（4）, by menadione sodium bisulfite, etamsylate and to carboxyl Bian amine ultrasonic grinding, cross 220 targeted fine powders, it is spare；
（5）, by step（1）And step（3）Glycerine is added in obtained extract, continuously adds step（2）Obtained medicinal extract, finally
Deionized water and step is added（4）Obtained fine powder, filtering, obtains filtrate；
（6）, the tissue substance of medicament-carried application immersed in hot water storgae, first with 99 DEG C of water stirring and washing 80min, speed of agitator
For 130r/min, after be cooled to 8 DEG C, stirring and washing 20min, step step is added（5）Obtained filtrate adjusts temperature, 75
Continue stirring and washing 80min, speed of agitator 130r/min at DEG C, continues to be heated to 98 with polyacrylamide softening agent is added
DEG C and keep 20min, take out the tissue substance of medicament-carried application, dewaterer is dehydrated 30min；
（7）, by step（6）In dewatered medicament-carried application tissue substance through Co radiation sterilization, drying is to get to described
Antibiotic property medical hemostatic degreasing cotton gauze.
Experiment 1
Hemostasis experiment is carried out to antibiotic property medical hemostatic degreasing cotton gauze of the present invention by embodiment 1-3 and comparative example 1-3.
Experimentation：
It is that 3-5 jin of rabbit is equally divided into 6 groups by the weight of health, every group 4, including embodiment 1-3 and comparative example 1-3, general
The depilation of experimental rabbit ear sterilizes, and under aseptic condition at rabbit or so ear edge end 1/3, the wound of 1cm long is cut with sterile surgical knife
Mouthful, it is cut open including the central aorta of ear, but ear is not cut through, anti-Hemostatic Oral Liquid is flowed out from inside, waits for that blood is full of
Follow-up blood coagulation test is carried out after the surface of a wound, and antibiotic property medical hemostatic degreasing cotton gauze of the present invention is weighed into (m1), hemostasis by compression, 10s
After take away antibiotic property medical hemostatic degreasing cotton gauze of the present invention, observe the haemostatic effect of embodiment 1-3 and comparative example 1-3.Without more
Time T1 is recorded when more blood are oozed out from material, is observed 1 time per 5s later, until hemostasis completely, records time T2, bleeding stopping period
For T1 and T2 average values.After the completion of hemostasis, accurate weighing sucks the cotton balls (m2) of blood, calculates amount of bleeding m=m2-m1.
Wound healing is carried out to antibiotic property medical hemostatic degreasing cotton gauze of the present invention by embodiment 1-3 and comparative example 1-3
Experiment：
It is that 3-5 jin of rabbit is equally divided into 6 groups by the weight of health, every group 4, including embodiment 1-3 and comparative example 1-3, use
3% yellow Jackets 30mg/kg intraperitoneal injections are anaesthetized, and mouse back backbone both sides hair is taken off, depilation area 4cm2, use
Boiling water scalds hair removal section, and with antibiotic property medical hemostatic degreasing cotton gauze flap coverage of the present invention, daily dressing is primary.
Following table is hemostasis property indices of the antibiotic property medical hemostatic degreasing cotton gauze of the present invention to rabbit.
In conclusion using the proportioning of drug application of the present invention（Embodiment 1-3）Rabbit bleeding time that is averaged it is remote
The proportioning of drug application of the present invention is not used considerably shorter than（Comparative example 1-3）The average bleeding time；Using of the present invention
The proportioning of drug application（Embodiment 1-3）Rabbit average bleeding far less than not using matching for drug application of the present invention
Than（Comparative example 1-3）Average bleeding；Using the proportioning of drug application of the present invention（Embodiment 1-3）Rabbit be averagely cured
It closes number of days and is far less than the proportioning for not using drug application of the present invention（Comparative example 1-3）Average healing days.
Experiment 2
By embodiment 1-3 and comparative example 1-3 to antibiotic property medical hemostatic degreasing cotton gauze bacteriostatic experiment of the present invention.
1, experimental strain：
Select the representative strain of operating room, staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.
2, experiment classification：
Bacteriostatic experiment divides experimental group and control group, experimental group to select inventive embodiments 1-3 antibiotic property medical hemostatic degreasing cotton gauzes,
Control group selects comparative example 1-3 antibiotic properties medical hemostatic degreasing cotton gauze of the present invention.
3, bacterium solution incubation step：
（1）The preparation of bacterium solution：Above-mentioned three kinds of strains are inoculated in respectively on three agar mediums, it is small that 48 are cultivated at 37 DEG C
When, it is inoculated in respectively in two fresh nutrient broth mediums from picking colonies typical in above-mentioned agar medium respectively, together
At a temperature of, it cultivates 24 hours, it is spare；
（2）By above-mentioned steps（1）The experimental strain supported 24 hours through nutrition broth cultivation dilutes 50 respectively with sterile nutrient broth
Times, each strain is sub-packed in multiple culture dishes, marks control group and experimental group respectively.
4, experimentation：
It is that 3-5 jin of rabbit is equally divided into 6 groups by the weight of health, every group 4, including embodiment 1-3 and comparative example 1-3, use
3% yellow Jackets 30mg/kg intraperitoneal injections are anaesthetized, and mouse back backbone both sides hair is taken off, depilation area 6cm2, use
Boiling water scalds hair removal section, by above-mentioned bacterium solution incubation step（2）Strain in multiple culture dishes is sprayed on hair removal section scald area and uses
Antibiotic property medical hemostatic degreasing cotton gauze flap coverage of the present invention, daily dressing are twice, every to the antibacterial of rabbit after 14 days
Performance indicator is detected.
Following table is antibacterial property indices of the antibiotic property medical hemostatic degreasing cotton gauze of the present invention to rabbit.
Common medical absorbent cotton yarn group does not have sterilizing ability in summary, the sterilizing ability of the embodiment 1-3 in experimental group
It is far longer than the sterilizing ability of comparative example 1-3 in control group.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail can carry out a variety of simple variants to technical scheme of the present invention within the scope of the technical concept of the present invention, this
A little simple variants all belong to the scope of protection of the present invention.It is further to note that described in above-mentioned specific implementation mode
Each particular technique feature can be combined by any suitable means, in order to avoid not in the case of no contradiction
Necessary repetition, the present invention no longer separately illustrate various combinations of possible ways.In addition, a variety of different implementations of the present invention
Arbitrary combination can also be carried out between mode, as long as it does not violate the idea of the present invention, it is public equally to should be considered as institute of the invention
The content opened.
Claims (6)
1. a kind of antibiotic property medical hemostatic degreasing cotton gauze, which is characterized in that the antibiotic property medical hemostatic degreasing cotton gauze by
Drug application and the tissue substance of medicament-carried application form, and the drug application is made of Chinese medicine and Western medicine；It is described medicament-carried
The tissue substance of application is by ancient gastral cavity azelon and cotton fiber is blended forms.
2. a kind of antibiotic property medical hemostatic degreasing cotton gauze, which is characterized in that be made the traditional Chinese medicine ingredients raw material composition and again
Measuring number is：55-85 parts of folium callicarpae pedunculatae, 53-83 parts of Radix Notoginseng, 51-81 parts of madder, 48-78 parts of Swertia vacillana (Hance) Maxim., 43-73 parts of cannalike dona rhizome, oil
40-70 parts of mandarin orange leaf；The raw material that the western medicine composition is made forms and parts by weight are：0.5-1.7 parts of menadione sodium bisulfite,
0.2-1.6 parts of etamsylate, to 0.1-1.5 parts of carboxyl Bian amine, the weight proportion of the Gu gastral cavity azelon and cotton fiber is 1-
2:8-10。
3. a kind of antibiotic property medical hemostatic degreasing cotton gauze according to claim 2, which is characterized in that the Chinese medicine is made
The raw material of ingredient forms and parts by weight are：75 parts of folium callicarpae pedunculatae, 69 parts of Radix Notoginseng, 65 parts of madder, 64 parts of Swertia vacillana (Hance) Maxim., cannalike dona rhizome 58
Part, 55 parts of emblic leafflower leaf；The raw material that the western medicine composition is made forms and parts by weight are：1.1 parts of menadione sodium bisulfite, phenol
0.9 part of sulphur ethamine, to 0.8 part of carboxyl Bian amine, the weight proportion of the Gu gastral cavity azelon and cotton fiber is 1.5:8-9.
4. according to claim 2 to a kind of antibiotic property medical hemostatic degreasing cotton gauze of claim 3 any one of them, feature
It is, the method that the antibiotic property medical hemostatic degreasing cotton gauze is made includes the following steps：
（1）, folium callicarpae pedunculatae and emblic leafflower leaf removed into impurity, dry, weed out grey bits, be placed in mortar and grind 40-100min, obtained
200 targeted fine powders, be eventually adding 50-80wt% ethyl alcohol and ethyl acetate extraction 5- hydroxyls -4 ', 3,6,7- tetramethoxies-Huang
Ketone, amlaic acid, Lupeol, cupreol, gallic acid and 3,6- digalloylglucoses obtain extract, spare；
（2）, Radix Notoginseng, Swertia vacillana (Hance) Maxim. and cannalike dona rhizome decocted 2-3 times in distilled water, it is 1-3 hours each, merge decoction liquor, filtering,
50wt% ethyl alcohol is added, refrigerates 10-12 hours, filtering and concentrating is spare at medicinal extract；
（3）, madder removed into stem seedling, remove soil and thin fibrous root, take madder piece, set that fry in pot to appearance be in coke black, it is internal
Strong yellow sprays clear water, cools, be placed in mortar and grind 60-120min, obtained 200 targeted fine powders, and passed through benzene and n-hexane
Extract madder color, oleanolic acid acetic acid esters, oleanolic aldehyde acetic acid esters, madder terpene triol, purpurin, purpuroxanthin, two
Hydrogen rubimaillin, 1- hydroxyl -2- carboxyl -3- methoxies
Base fears quinone, 2'- methoxyl group rubimaillins, obtains extract, spare；
（4）, by menadione sodium bisulfite, etamsylate and to carboxyl Bian amine ultrasonic grinding, cross 220 targeted fine powders, it is spare；
（5）, by step（1）And step（3）Glycerine is added in obtained extract, continuously adds step（2）Obtained medicinal extract, finally
Deionized water and step is added（4）Obtained fine powder, filtering, obtains filtrate；
（6）, the tissue substance of medicament-carried application immersed in hot water storgae, first use 97-100 DEG C of water stirring and washing 40-80min,
After be cooled to 5-10 DEG C, step step is added in stirring and washing 10-20 minutes（5）Obtained filtrate adjusts temperature, at 60-80 DEG C
Lower continuation stirring and washing 40-80min continues to be heated to 97-100 DEG C and keeps 20min in addition softening agent with polyacrylamide,
The tissue substance of medicament-carried application is taken out, dewaterer is dehydrated 30min；
（7）, by step（6）In dewatered medicament-carried application tissue substance through Co radiation sterilization, drying is to get to described
Antibiotic property medical hemostatic degreasing cotton gauze.
5. a kind of antibiotic property medical hemostatic degreasing cotton gauze according to claim 4, which is characterized in that the step（6）
The rotating speed of middle stirring and washing is 120-160r/min.
6. a kind of antibiotic property medical hemostatic degreasing cotton gauze according to claim 4, which is characterized in that the step（6）
In softening agent be fatty diglycollic amide, double octadecylsuccinic acid sulfonate or pentaerythritol fatty ester.
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| CN111249264A (en) * | 2020-02-18 | 2020-06-09 | 东北农业大学 | Application of gallic acid in reversing antibiotic resistance of streptococcus suis |
| CN113073469A (en) * | 2021-03-10 | 2021-07-06 | 浙江大学 | Preparation method of medical antibacterial gauze |
| CN114904045A (en) * | 2022-05-31 | 2022-08-16 | 山东大学 | Hydrogel medical dressing containing traditional Chinese medicine extract and preparation method thereof |
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Application publication date: 20180904 |