CN106620819A - Medical rapid hemostatic gauze and preparation method thereof - Google Patents
Medical rapid hemostatic gauze and preparation method thereof Download PDFInfo
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- CN106620819A CN106620819A CN201611126998.5A CN201611126998A CN106620819A CN 106620819 A CN106620819 A CN 106620819A CN 201611126998 A CN201611126998 A CN 201611126998A CN 106620819 A CN106620819 A CN 106620819A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Abstract
The invention provides medical rapid hemostatic gauze and a preparation method thereof. The preparation method comprises the following steps: (1) cleaning mangosteen barks, drying, dehydrating, and grinding the mangosteen barks to a fineness of 200-300 meshes; (2) crushing auriculed bristlefern, Chrysosplenium lanuginosum, milky-white anaphalis and Leucosceptrum canum by virtue of ball-milling, adding 90wt% ethanol, carrying out reflux extraction, combining extracting solutions, carrying out water bath concentration until the combined extracting solution is dry, transferring the combined extracting solution into a drying oven, and drying to constant weight, so as to obtain a powdery extract; (3) heating deionized water to 80-100 DEG C, maintaining the temperature, and slowly adding oxhide gelatin until oxhide gelatin is completely dissolved in water; and (4) cooling to 30-50 DEG C, sequentially adding beeswax, borneol, aloe juice, the mangosteen bark powder prepared in the step (1) and the powdery extract prepared in the step (2), uniformly stirring to obtain a mixture, cooling to the room temperature, and smearing a fabric with the mixture. The medical rapid hemostatic gauze is capable of protecting wounds and is unlikely to adhere, so that the bleeding amount is reduced, the bleeding time is shortened, and the healing of the wounds is promoted.
Description
Technical field
The present invention relates to field of medical materials, and in particular to a kind of medical quick-acting haemostatic powder gauze and preparation method thereof.
Background technology
Hemostasis is one of core of essential surgical skills technology, and the surgical procedures at any position of human body are almost bar none
It is related to bleeding and hemostasis, hemostatic technique is developed into numerous and complicated under the conditions of modern surgery by past simple apparatus haemostatic measures
Complicated technical system.The application of wherein hemostatic material becomes a part important during this.Traditional cotton product material：Pass
System such as the simple absorbent cotton of cotton products material, gauze etc., it is cheap, it is easy to use, but only physical protection is played to wound surface and act on,
Without thrombin, and easily adhesion wound surface.Gauze is common medical supplies, and it is slow, easy that traditional hemostatic gauze has hemostasis
Adhesion wound, the problems such as do not damage wound surface, in order to ensure the life security of patient, it is quick to need to develop haemostatic effect, Neng Goubao
Shield wound surface, the new hemostatic gauze for promoting wound healing.The hemostatic gauze colloidal gel containing Chinese herbal medicine, nothing will be smeared on gauze
A kind of preferable product is suspected to be, using the active component of Chinese herbal medicine, disinfection, hemostasis and pain-relieving is realized, is promoted wound healing etc.
Function, gentle non-stimulated, little to harm compared to normal gauze simple production process, the property of medicine, patient acceptance is high, market
Using value is huge.
The content of the invention
The technical problem to be solved：It is an object of the invention to provide a kind of medical quick-acting haemostatic powder gauze, protects wound, it is difficult
Adhesion, can reduce amount of bleeding, shorten the bleeding time, promote the healing of wound.
Technical scheme：A kind of medical quick-acting haemostatic powder gauze, the medical quick-acting haemostatic powder gauze is by medicine application and carrier band institute
The fabric composition of medicine application is stated, described medicine application is prepared from by weight by following component：Aloe juice 40-60
Part, Borneolum Syntheticum 0.5-5 parts, Apis cerana Fabriciuss 2-8 parts, gelatinum oxhide 0.5-1.5 parts, deionized water 5-15 parts, Garcinia mangostana bark 0.5-4 parts, Trichomanes auriculatum Bl- Cop
2-5 parts, Chrysosplenium lanuginosum Hook. F. Et Thomss 2-5 parts, Herba Anaphalidis Lacteae 0.8-4 parts, Flos Cannae Indicae's 1.5-2.5 parts, meter Tuan Hua 0.5-1.8 parts.
It is further preferred that described a kind of medical quick-acting haemostatic powder gauze, the medical quick-acting haemostatic powder gauze is applied by medicine
Agent and the fabric composition of the carrier band medicine application, described medicine application is prepared from by weight by following component：
Aloe juice 48-58 parts, Borneolum Syntheticum 1.5-3 parts, Apis cerana Fabriciuss 4-6 parts, gelatinum oxhide 0.8-1.2 parts, deionized water 8-12 parts, Garcinia mangostana bark 1-
3 parts, Trichomanes auriculatum Bl- Cop 3-4 parts, Chrysosplenium lanuginosum Hook. F. Et Thomss 3-4 parts, Herba Anaphalidis Lacteae 1.5-3.5 parts, Flos Cannae Indicae's 1.8-2.2 parts, meter Tuan Hua 0.8-1.5
Part.
The preparation method of above-mentioned medical quick-acting haemostatic powder gauze, comprises the following steps：
（1）Garcinia mangostana bark is cleaned into drying and dewatering, the fineness being ground to is 200-300 mesh；
（2）It is 2 by Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss, Herba Anaphalidis Lacteae, Flos Cannae Indicae, meter Tuan Hua ball mill pulverizing, ratio of grinding media to material:1, Ball-milling Time
For 30-50min, then add people's 90wt% ethanol, solid-to-liquid ratio is 2:1-6:1, reflux, extract, 3 times, united extraction liquid, water-bath concentration
To dry, oven drying is moved into constant weight, obtain powdered extract；
（3）Deionized water is heated to into 80-100 DEG C, insulation is slowly added to gelatinum oxhide, completely soluble in water to gelatinum oxhide；
（4）30-50 DEG C is cooled to, Apis cerana Fabriciuss, Borneolum Syntheticum, Aloe juice, step is sequentially added（1）Obtained Garcinia mangostana bark powder, step（2）
Obtained powdered extract, stirs, and is down to room temperature, is applied on fabric.
Further, the preparation method of described a kind of medical quick-acting haemostatic powder gauze, the step（1）Middle fineness is 220-
250 mesh.
Further, the preparation method of described a kind of medical quick-acting haemostatic powder gauze, the step（2）Middle Ball-milling Time is
35-45min, solid-to-liquid ratio 3:1-5:1.
Further, the preparation method of described a kind of medical quick-acting haemostatic powder gauze, the step（3）In be heated to 85-
95℃。
Further, the preparation method of described a kind of medical quick-acting haemostatic powder gauze, the step（4）Middle fabric is cotton
Non-woven fabrics.
Further, the preparation method of described a kind of medical quick-acting haemostatic powder gauze, it is characterised in that：The step（4）
In be cooled to 30-40 DEG C.
Beneficial effect：The medical quick-acting haemostatic powder gauze of the present invention is in addition Herba Anaphalidis Lacteae, Flos Cannae Indicae, rice group flower extract
Afterwards, the bleeding time has been shortened, has been occurred to the 32s that only need that stops blooding completely from bleeding, amount of bleeding has been only 0.085g；Garcinia mangostana bark powder,
Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss extract are to being obviously promoted the healing of wound.
Specific embodiment
Embodiment 1
A kind of medical quick-acting haemostatic powder gauze, the medical quick-acting haemostatic powder gauze is knitted with the medicine application is carried by medicine application
Thing composition, described medicine application is prepared from by weight by following component：40 parts of Aloe juice, 0.5 part of Borneolum Syntheticum, Apis cerana Fabriciuss
2 parts, 1.5 parts of gelatinum oxhide, 15 parts of deionized water, 0.5 part of Garcinia mangostana bark, 5 parts of Trichomanes auriculatum Bl- Cop, 5 parts of Chrysosplenium lanuginosum Hook. F. Et Thomss, 0.8 part of Herba Anaphalidis Lacteae,
2.5 parts of Flos Cannae Indicae, 1.8 parts of meter Tuan Hua.
The preparation method of above-mentioned medical quick-acting haemostatic powder gauze is：（1）Garcinia mangostana bark is cleaned into drying and dewatering, what is be ground to is thin
Spend for 200 mesh；（2）It is 2 by Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss, Herba Anaphalidis Lacteae, Flos Cannae Indicae, meter Tuan Hua ball mill pulverizing, ratio of grinding media to material:1, ball
Then plus people's 90wt% ethanol consume time as 30min, solid-to-liquid ratio is 2:1, reflux, extract, 3 times, united extraction liquid, water-bath is concentrated into
It is dry, oven drying is moved into constant weight, obtain powdered extract；（3）Deionized water is heated to into 80 DEG C, insulation is slowly added to Huang
Gelatin, it is completely soluble in water to gelatinum oxhide；（4）50 DEG C are cooled to, Apis cerana Fabriciuss, Borneolum Syntheticum, Aloe juice, step is sequentially added（1）It is obtained
Garcinia mangostana bark powder, step（2）Obtained powdered extract, stirs, and is down to room temperature, is applied on fabric.
Embodiment 2
A kind of medical quick-acting haemostatic powder gauze, the medical quick-acting haemostatic powder gauze is knitted with the medicine application is carried by medicine application
Thing composition, described medicine application is prepared from by weight by following component：60 parts of Aloe juice, 5 parts of Borneolum Syntheticum, Apis cerana Fabriciuss 8
Part, 0.5 part of gelatinum oxhide, 5 parts of deionized water, 4 parts of Garcinia mangostana bark, 2 parts of Trichomanes auriculatum Bl- Cop, 2 parts of Chrysosplenium lanuginosum Hook. F. Et Thomss, 4 parts of Herba Anaphalidis Lacteae, Canna generalis Bailey
Spend 1.5 parts, 0.5 part of meter Tuan Hua.
The preparation method of above-mentioned medical quick-acting haemostatic powder gauze is：（1）Garcinia mangostana bark is cleaned into drying and dewatering, what is be ground to is thin
Spend for 300 mesh；（2）It is 2 by Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss, Herba Anaphalidis Lacteae, Flos Cannae Indicae, meter Tuan Hua ball mill pulverizing, ratio of grinding media to material:1, ball
Then plus people's 90wt% ethanol consume time as 50min, solid-to-liquid ratio is 6:1, reflux, extract, 3 times, united extraction liquid, water-bath is concentrated into
It is dry, oven drying is moved into constant weight, obtain powdered extract；（3）Deionized water is heated to into 100 DEG C, insulation is slowly added to Huang
Gelatin, it is completely soluble in water to gelatinum oxhide；（4）30 DEG C are cooled to, Apis cerana Fabriciuss, Borneolum Syntheticum, Aloe juice, step is sequentially added（1）It is obtained
Garcinia mangostana bark powder, step（2）Obtained powdered extract, stirs, and is down to room temperature, is applied on fabric.
Embodiment 3
A kind of medical quick-acting haemostatic powder gauze, the medical quick-acting haemostatic powder gauze is knitted with the medicine application is carried by medicine application
Thing composition, described medicine application is prepared from by weight by following component：48 parts of Aloe juice, 1.5 parts of Borneolum Syntheticum, Apis cerana Fabriciuss
4 parts, it is 1.2 parts of gelatinum oxhide, 12 parts of deionized water, 1 part of Garcinia mangostana bark, 4 parts of Trichomanes auriculatum Bl- Cop, 4 parts of Chrysosplenium lanuginosum Hook. F. Et Thomss, 1.5 parts of Herba Anaphalidis Lacteae, beautiful
2.2 parts of people any of several broadleaf plants, 1.5 parts of meter Tuan Hua.
The preparation method of above-mentioned medical quick-acting haemostatic powder gauze is：（1）Garcinia mangostana bark is cleaned into drying and dewatering, what is be ground to is thin
Spend for 220 mesh；（2）It is 2 by Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss, Herba Anaphalidis Lacteae, Flos Cannae Indicae, meter Tuan Hua ball mill pulverizing, ratio of grinding media to material:1, ball
Then plus people's 90wt% ethanol consume time as 35min, solid-to-liquid ratio is 5:1, reflux, extract, 3 times, united extraction liquid, water-bath is concentrated into
It is dry, oven drying is moved into constant weight, obtain powdered extract；（3）Deionized water is heated to into 85 DEG C, insulation is slowly added to Huang
Gelatin, it is completely soluble in water to gelatinum oxhide；（4）40 DEG C are cooled to, Apis cerana Fabriciuss, Borneolum Syntheticum, Aloe juice, step is sequentially added（1）It is obtained
Garcinia mangostana bark powder, step（2）Obtained powdered extract, stirs, and is down to room temperature, is applied on fabric.
Embodiment 4
A kind of medical quick-acting haemostatic powder gauze, the medical quick-acting haemostatic powder gauze is knitted with the medicine application is carried by medicine application
Thing composition, described medicine application is prepared from by weight by following component：58 parts of Aloe juice, 3 parts of Borneolum Syntheticum, Apis cerana Fabriciuss 6
Part, 0.8 part of gelatinum oxhide, 8 parts of deionized water, 3 parts of Garcinia mangostana bark, 3 parts of Trichomanes auriculatum Bl- Cop, 3 parts of Chrysosplenium lanuginosum Hook. F. Et Thomss, 3.5 parts of Herba Anaphalidis Lacteae, beauty
1.8 parts of any of several broadleaf plants, 0.8 part of meter Tuan Hua.
The preparation method of above-mentioned medical quick-acting haemostatic powder gauze is：（1）Garcinia mangostana bark is cleaned into drying and dewatering, what is be ground to is thin
Spend for 250 mesh；（2）It is 2 by Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss, Herba Anaphalidis Lacteae, Flos Cannae Indicae, meter Tuan Hua ball mill pulverizing, ratio of grinding media to material:1, ball
Then plus people's 90wt% ethanol consume time as 45min, solid-to-liquid ratio is 3:1, reflux, extract, 3 times, united extraction liquid, water-bath is concentrated into
It is dry, oven drying is moved into constant weight, obtain powdered extract；（3）Deionized water is heated to into 95 DEG C, insulation is slowly added to Huang
Gelatin, it is completely soluble in water to gelatinum oxhide；（4）30 DEG C are cooled to, Apis cerana Fabriciuss, Borneolum Syntheticum, Aloe juice, step is sequentially added（1）It is obtained
Garcinia mangostana bark powder, step（2）Obtained powdered extract, stirs, and is down to room temperature, is applied on fabric.
Embodiment 5
A kind of medical quick-acting haemostatic powder gauze, the medical quick-acting haemostatic powder gauze is knitted with the medicine application is carried by medicine application
Thing composition, described medicine application is prepared from by weight by following component：55 parts of Aloe juice, 2.2 parts of Borneolum Syntheticum, Apis cerana Fabriciuss
5 parts, 1 part of gelatinum oxhide, 10 parts of deionized water, 2 parts of Garcinia mangostana bark, 3.5 parts of Trichomanes auriculatum Bl- Cop, 3.5 parts of Chrysosplenium lanuginosum Hook. F. Et Thomss, 2.5 parts of Herba Anaphalidis Lacteae,
2 parts of Flos Cannae Indicae, 1.2 parts of meter Tuan Hua.
The preparation method of above-mentioned medical quick-acting haemostatic powder gauze is：（1）Garcinia mangostana bark is cleaned into drying and dewatering, what is be ground to is thin
Spend for 240 mesh；（2）It is 2 by Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss, Herba Anaphalidis Lacteae, Flos Cannae Indicae, meter Tuan Hua ball mill pulverizing, ratio of grinding media to material:1, ball
Then plus people's 90wt% ethanol consume time as 40min, solid-to-liquid ratio is 4:1, reflux, extract, 3 times, united extraction liquid, water-bath is concentrated into
It is dry, oven drying is moved into constant weight, obtain powdered extract；（3）Deionized water is heated to into 90 DEG C, insulation is slowly added to Huang
Gelatin, it is completely soluble in water to gelatinum oxhide；（4）35 DEG C are cooled to, Apis cerana Fabriciuss, Borneolum Syntheticum, Aloe juice, step is sequentially added（1）It is obtained
Garcinia mangostana bark powder, step（2）Obtained powdered extract, stirs, and is down to room temperature, is applied on fabric.
Comparative example 1
A kind of medical quick-acting haemostatic powder gauze, the medical quick-acting haemostatic powder gauze is knitted with the medicine application is carried by medicine application
Thing composition, described medicine application is prepared from by weight by following component：40 parts of Aloe juice, 0.5 part of Borneolum Syntheticum, Apis cerana Fabriciuss
2 parts, 1.5 parts of gelatinum oxhide, 15 parts of deionized water, 0.8 part of Herba Anaphalidis Lacteae, 2.5 parts of Flos Cannae Indicae, 1.8 parts of meter Tuan Hua.
The preparation method of above-mentioned medical quick-acting haemostatic powder gauze is：（1）By Herba Anaphalidis Lacteae, Flos Cannae Indicae, rice group bouquet pulverizing
Broken, ratio of grinding media to material is 2:1, Ball-milling Time is 30min, then adds people's 90wt% ethanol, and solid-to-liquid ratio is 2:1, reflux, extract, 3 times merges
Extracting solution, water-bath is concentrated to dryness, and moves into oven drying to constant weight, obtains powdered extract；（2）Deionized water is heated to into 80
DEG C, insulation is slowly added to gelatinum oxhide, completely soluble in water to gelatinum oxhide；（3）Be cooled to 50 DEG C, sequentially add Apis cerana Fabriciuss, Borneolum Syntheticum,
Aloe juice, step（1）Obtained powdered extract, stirs, and is down to room temperature, is applied on fabric.
Comparative example 2
A kind of medical quick-acting haemostatic powder gauze, the medical quick-acting haemostatic powder gauze is knitted with the medicine application is carried by medicine application
Thing composition, described medicine application is prepared from by weight by following component：60 parts of Aloe juice, 5 parts of Borneolum Syntheticum, Apis cerana Fabriciuss 8
Part, 0.5 part of gelatinum oxhide, 5 parts of deionized water, 4 parts of Garcinia mangostana bark, 2 parts of Trichomanes auriculatum Bl- Cop, 2 parts of Chrysosplenium lanuginosum Hook. F. Et Thomss.
The preparation method of above-mentioned medical quick-acting haemostatic powder gauze is：（1）Garcinia mangostana bark is cleaned into drying and dewatering, what is be ground to is thin
Spend for 300 mesh；（2）It is 2 by Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss ball mill pulverizing, ratio of grinding media to material:1, Ball-milling Time is 50min, then adds people
90wt% ethanol, solid-to-liquid ratio is 6:1, reflux, extract, 3 times, united extraction liquid, water-bath is concentrated to dryness, and moves into oven drying to constant weight,
Obtain powdered extract；（3）Deionized water is heated to into 100 DEG C, insulation is slowly added to gelatinum oxhide, is completely dissolved in gelatinum oxhide
In water；（4）30 DEG C are cooled to, Apis cerana Fabriciuss, Borneolum Syntheticum, Aloe juice, step is sequentially added（1）Obtained Garcinia mangostana bark powder, step（2）System
The powdered extract for obtaining, stirs, and is down to room temperature, is applied on fabric.
Hemostasis experiment：7 groups, including embodiment 1-5 and comparative example 1,2 will be equally divided into for trying rabbit, by experimental rabbit ear
Depilation, sterilization, under aseptic condition at rabbit or so ear edge end 1/3, cut the wound of 1cm length, wherein wrapping with sterile surgical knife
Include one aorta of ear central authorities to be cut open, but ear does not cut through, and anti-Hemostatic Oral Liquid goes out from interior flow measurement, carries out after blood is full of wound surface
Follow-up blood coagulation test, after medical quick-acting haemostatic powder gauze is weighed, gauze is taken away in hemostasis by compression after 10s, observes stopping for various materials
Blood effect.Time T1 is recorded when oozing out from material without more blood, is observed 1 time per 5s later, until stopping blooding completely, record the time
T2, bleeding stopping period is T1 and T2 meansigma methodss.After the completion of hemostasis, accurate weighing sucks the cotton balls (m2) of blood, calculates amount of bleeding m=
M2-m1.
Wound healing is tested：7 groups, including embodiment 1-5 and comparative example 1,2 will be equally divided into for trying mouse, with 3% penta bars
Than appropriate sodium 30mg/kg intraperitoneal injections anesthesia, mouse back spinal column both sides are taken off by hair, lose hair or feathers area 4cm2, will with boiled water
Hair removal section is scalded, and uses gauze flap coverage, and daily dressing is once.
The property indices of material of the present invention see the table below, it may be seen that this medical quick-acting haemostatic powder gauze is in addition breast
After Bai Xiangqing, Flos Cannae Indicae, rice group flower extract, the bleeding time is shortened, has been occurred to the 32s that only need that stops blooding completely from bleeding,
Amount of bleeding is only 0.085g；Garcinia mangostana bark powder, Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss extract are to being obviously promoted the healing of wound.
The property indices of the medical quick-acting haemostatic powder gauze of table 1
Claims (8)
1. a kind of medical quick-acting haemostatic powder gauze, it is characterised in that the medical quick-acting haemostatic powder gauze is by medicine application and carrier band institute
The fabric composition of medicine application is stated, described medicine application is prepared from by weight by following component：Aloe juice 40-60
Part, Borneolum Syntheticum 0.5-5 parts, Apis cerana Fabriciuss 2-8 parts, gelatinum oxhide 0.5-1.5 parts, deionized water 5-15 parts, Garcinia mangostana bark 0.5-4 parts, Trichomanes auriculatum Bl- Cop
2-5 parts, Chrysosplenium lanuginosum Hook. F. Et Thomss 2-5 parts, Herba Anaphalidis Lacteae 0.8-4 parts, Flos Cannae Indicae's 1.5-2.5 parts, meter Tuan Hua 0.5-1.8 parts.
2. a kind of medical quick-acting haemostatic powder gauze according to claim 1, it is characterised in that the medical quick-acting haemostatic powder gauze is
It is made up of medicine application and the fabric of the carrier band medicine application, described medicine application is made by weight by following component
It is standby to form：Aloe juice 48-58 parts, Borneolum Syntheticum 1.5-3 parts, Apis cerana Fabriciuss 4-6 parts, gelatinum oxhide 0.8-1.2 parts, deionized water 8-12 parts, mountain
Bamboo bark 1-3 parts, Trichomanes auriculatum Bl- Cop 3-4 parts, Chrysosplenium lanuginosum Hook. F. Et Thomss 3-4 parts, Herba Anaphalidis Lacteae 1.5-3.5 parts, Flos Cannae Indicae's 1.8-2.2 parts, rice group
Flower 0.8-1.5 parts.
3. a kind of preparation method of medical quick-acting haemostatic powder gauze, it is characterised in that comprise the following steps：
（1）Garcinia mangostana bark is cleaned into drying and dewatering, the fineness being ground to is 200-300 mesh；
（2）It is 2 by Trichomanes auriculatum Bl- Cop, Chrysosplenium lanuginosum Hook. F. Et Thomss, Herba Anaphalidis Lacteae, Flos Cannae Indicae, meter Tuan Hua ball mill pulverizing, ratio of grinding media to material:1, Ball-milling Time
For 30-50min, then add people's 90wt% ethanol, solid-to-liquid ratio is 2:1-6:1, reflux, extract, 3 times, united extraction liquid, water-bath concentration
To dry, oven drying is moved into constant weight, obtain powdered extract；
（3）Deionized water is heated to into 80-100 DEG C, insulation is slowly added to gelatinum oxhide, completely soluble in water to gelatinum oxhide；
（4）30-50 DEG C is cooled to, Apis cerana Fabriciuss, Borneolum Syntheticum, Aloe juice, step is sequentially added（1）Obtained Garcinia mangostana bark powder, step（2）
Obtained powdered extract, stirs, and is down to room temperature, is applied on fabric.
4. the preparation method of a kind of medical quick-acting haemostatic powder gauze according to claim 3, it is characterised in that：The step
（1）Middle fineness is 220-250 mesh.
5. the preparation method of a kind of medical quick-acting haemostatic powder gauze according to claim 3, it is characterised in that：The step
（2）Middle Ball-milling Time be 35-45min, solid-to-liquid ratio 3:1-5:1.
6. the preparation method of a kind of medical quick-acting haemostatic powder gauze according to claim 3, it is characterised in that：The step
（3）In be heated to 85-95 DEG C.
7. the preparation method of a kind of medical quick-acting haemostatic powder gauze according to claim 3, it is characterised in that：The step
（4）Middle fabric is cotton non-woven fabrics.
8. the preparation method of a kind of medical quick-acting haemostatic powder gauze according to claim 3, it is characterised in that：The step
（4）In be cooled to 30-40 DEG C.
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