CN104264485A - Preparation method of medical bandage coated with polyurethane resin prepolymer - Google Patents
Preparation method of medical bandage coated with polyurethane resin prepolymer Download PDFInfo
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- CN104264485A CN104264485A CN201410477406.9A CN201410477406A CN104264485A CN 104264485 A CN104264485 A CN 104264485A CN 201410477406 A CN201410477406 A CN 201410477406A CN 104264485 A CN104264485 A CN 104264485A
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- polyurethane resin
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- performed polymer
- medical bandage
- coated
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- 229920005749 polyurethane resin Polymers 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 229920001730 Moisture cure polyurethane Polymers 0.000 claims abstract description 21
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 20
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 15
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 10
- 239000011787 zinc oxide Substances 0.000 claims abstract description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
- 239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 8
- 229920000570 polyether Polymers 0.000 claims abstract description 8
- 239000003054 catalyst Substances 0.000 claims abstract description 7
- 239000007822 coupling agent Substances 0.000 claims abstract description 7
- 239000012024 dehydrating agents Substances 0.000 claims abstract description 7
- 239000000314 lubricant Substances 0.000 claims abstract description 7
- 238000005096 rolling process Methods 0.000 claims abstract description 7
- 238000010008 shearing Methods 0.000 claims abstract description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 5
- 239000002105 nanoparticle Substances 0.000 claims abstract description 5
- 238000001035 drying Methods 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims abstract description 4
- 229920000642 polymer Polymers 0.000 claims description 31
- 239000002245 particle Substances 0.000 claims description 27
- 239000002585 base Substances 0.000 claims description 19
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- 229920002545 silicone oil Polymers 0.000 claims description 7
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 6
- 239000013530 defoamer Substances 0.000 claims description 6
- 235000019441 ethanol Nutrition 0.000 claims description 6
- 150000002334 glycols Chemical class 0.000 claims description 6
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 6
- ONIKNECPXCLUHT-UHFFFAOYSA-N 2-chlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1Cl ONIKNECPXCLUHT-UHFFFAOYSA-N 0.000 claims description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 5
- 229910052709 silver Inorganic materials 0.000 claims description 5
- 239000004332 silver Substances 0.000 claims description 5
- 239000011032 tourmaline Substances 0.000 claims description 5
- 229940070527 tourmaline Drugs 0.000 claims description 5
- 229910052613 tourmaline Inorganic materials 0.000 claims description 5
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 4
- 239000002808 molecular sieve Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims description 4
- 239000004135 Bone phosphate Substances 0.000 claims description 3
- 206010013786 Dry skin Diseases 0.000 claims description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 3
- 239000004705 High-molecular-weight polyethylene Substances 0.000 claims description 3
- 229920004933 Terylene® Polymers 0.000 claims description 3
- UKLDJPRMSDWDSL-UHFFFAOYSA-L [dibutyl(dodecanoyloxy)stannyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[Sn](CCCC)(CCCC)OC(=O)CCCCCCCCCCC UKLDJPRMSDWDSL-UHFFFAOYSA-L 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 3
- 239000000920 calcium hydroxide Substances 0.000 claims description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 3
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000292 calcium oxide Substances 0.000 claims description 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 229940035423 ethyl ether Drugs 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 3
- 229940096992 potassium oleate Drugs 0.000 claims description 3
- MLICVSDCCDDWMD-KVVVOXFISA-M potassium;(z)-octadec-9-enoate Chemical compound [K+].CCCCCCCC\C=C/CCCCCCCC([O-])=O MLICVSDCCDDWMD-KVVVOXFISA-M 0.000 claims description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract description 8
- 239000006229 carbon black Substances 0.000 abstract description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 239000002518 antifoaming agent Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000004744 fabric Substances 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 150000004072 triols Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 239000002260 anti-inflammatory agent Substances 0.000 description 7
- 230000001741 anti-phlogistic effect Effects 0.000 description 7
- 229920001451 polypropylene glycol Polymers 0.000 description 7
- 239000002131 composite material Substances 0.000 description 6
- 230000036592 analgesia Effects 0.000 description 5
- 206010001497 Agitation Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000009413 insulation Methods 0.000 description 3
- 238000010907 mechanical stirring Methods 0.000 description 3
- 239000012299 nitrogen atmosphere Substances 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 238000007761 roller coating Methods 0.000 description 3
- 229910000077 silane Inorganic materials 0.000 description 3
- 238000007711 solidification Methods 0.000 description 3
- 230000008023 solidification Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 229910010413 TiO 2 Inorganic materials 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229960003511 macrogol Drugs 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000010436 fluorite Substances 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- GQYHUHYESMUTHG-UHFFFAOYSA-N lithium niobate Chemical compound [Li+].[O-][Nb](=O)=O GQYHUHYESMUTHG-UHFFFAOYSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polyurethanes Or Polyureas (AREA)
Abstract
The invention discloses a preparation method of a medical bandage coated with a polyurethane resin prepolymer. The preparation method comprises the following steps: a. adding aromatic diisocyanate and a dehydrating agent to a reaction kettle, stirring, adding polyether glycol, polyether triols, high molecular polyethylene glycol, a defoaming agent, white carbon black, a lubricant and a catalyst, heating up to 75 DEG C and preserving heat, and then cooling to room temperature to obtain a polyurethane prepolymer; b. adding powdery nanoparticles, zinc oxide and a far infrared emitting material to absolute ethyl alcohol and a coupling agent solution, sufficiently stirring, drying and grinding to obtain functional powder; c. adding the functional powder to the polyurethane prepolymer, and sufficiently stirring for reacting under a nitrogen protection condition to obtain the polyurethane resin prepolymer; and d. uniformly coating base cloth with the polyurethane resin prepolymer, and conveying, rolling, coiling, shearing, sealing and bagging to obtain the medical bandage coated with the polyurethane resin prepolymer.
Description
Technical field
The present invention relates to macromolecule curable product technical field, be specially a kind of preparation method being coated with the medical bandage of polyurethane resin performed polymer.
Background technology
Existing polyurethane bandage is mainly used in fracturing, abarticulation damage, correction deformity fixing, also can be used for peripheral nerve, blood vessel, tendon breakdown postoperative fixing, because surgery bone fracture generally about needs the recovery in 4-10 week, present bandage contacts with body surface for a long time, the moisture that human body skin top layer gives out, bacterium, fungi etc. can be trapped in the interface of bandage and body surface, grow breeding, form the allergic phenomena such as itch, redness and then infection to be wound place, cause qi and blood not smooth, be unfavorable for the recovery of bone fracture, the misery of making patients.The patent No.: CN102886065A discloses a kind of Chinese medicine composition for medical polymer bandage, take acrylate as macromolecule performed polymer, though have anti-inflammatory analgetic, effect promoting blood circulation and removing blood stasis after bandage solidification, but the effect that the intensity of bandage is low, do not have sterilization Promotive union, and irritant smell in acrylate solidification process, have a strong impact on the respiratory health of doctor patient, use inconvenience.The patent No.: CN103405802A discloses a kind of organic synthesis medicine quaternary ammonium salt that uses as the preparation method of the polyurethane bandage of the functive of sterilizing and itch-relieving, but use that methyl alcohol, acetone etc. are organic, toxic solvent in process of production in a large number, great pressure is caused to environment, is unfavorable for large-scale application.
Polyurethane resin has a wide range of applications in medical material, electronics, automobile, house ornamentation because of excellent mechanical property after the design of its molecule broadness, solidification.Nanometer-level silver, copper powder have effect of outstanding bactericidal antiphlogistic, for multiple fields, oxide powder and zinc have hemostasis, sterilization convergence, antipyretic-antalgic effect be widely used in the treatment of wounds after ophthalmic surgical, and inorganic drug duration of efficacy is of a specified duration, Be very effective, few generation drug resistance, side effect is little.Nanoscale far-infrared material has promotion cell metabolism, the circulation of strengthening local blood, strengthen the oxygen-supplying amount of cell, improve the blood supply oxygen condition of lesion, and by neuron responsing reaction, the function of immune cell activated, its infrared fuel factor reduces the excitability of nerve endings, plays the effect alleviating pain.Therefore, market is needed a kind of medical polymer bandage badly, not only can play fixation, the effect of bactericidal antiphlogistic, antipruritic analgesia, Promotive union can also be played site of injury.
Summary of the invention
For above-mentioned technical problem, the present invention discloses a kind of preparation method being coated with the medical bandage of polyurethane resin performed polymer, comprise the following steps: a, the preparation of base polyurethane prepolymer for use as: the aromatic diisocyanate adding 50 ~ 65 parts in three mouthfuls of reactors, the dehydrating agent of 0.1 ~ 1 part, stir at ambient temperature after 20 minutes, add the polyether Glycols of 20 ~ 30 parts again, the polyether-tribasic alcohol of 2 ~ 5 parts, the high molecular weight polyethylene glycol of 5 ~ 15 parts, the defoamer of 2 ~ 4 parts, the white carbon of 5 ~ 10 parts, the lubricant of 1 ~ 5 part, the catalyst of 1 ~ 2 part, slowly be warming up to 75 DEG C, be incubated 1.5 hours, then room temperature is down to, then obtain base polyurethane prepolymer for use as, the preparation of b, functive powder: pulverous nanometer particle, zinc oxide, far-infrared emission material are added in absolute ethyl alcohol and coupling agent solution, 70 DEG C are fully stirred 3 ~ 4 hours, and 80 DEG C of dryings 5 hours, grind, then obtain functive powder, the preparation of c, polyurethane resin performed polymer: according to 15% of the mass fraction of base polyurethane prepolymer for use as resin, joins in base polyurethane prepolymer for use as by functive powder, fully stirs 1 ~ 2 hour, then obtain polyurethane resin performed polymer under nitrogen protection condition, the preparation of d, medical bandage: under the condition of air humidity lower than 10%, employing twin-roll applies, polyurethane resin performed polymer is evenly coated in Ji Bushang, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the medical bandage being coated with polyurethane resin performed polymer.
Preferably, in described step a, aromatic diisocyanate is one or more in MDI, TDI, NDI; Dehydrating agent is one or more in maleic anhydride, chlorobenzoyl chloride, pyrovinic acid; Polyether Glycols is one or more in PEG or PPG of 300 ~ 6000 of molecular weight; Lubricant is silicone oil or polyethylene glycol oxide; Defoamer is one or more in silicone oil, calcium oxide, calcium hydroxide, molecular sieve; Catalyst is one or more in potassium oleate, triethylene diamine, four ethene triamines, two morpholine ethylether, dibutyl tin laurate.
Preferably, in described step b, nanometer particle is the one in silver nanoparticle level particle, copper nanometer particle, zinc oxide nano meter level particle, tourmaline nanometer particle.
Preferably, in described steps d, described Ji Bu is polyester or terylene, and Unit Weight is 80 ~ 130g/m, and cross direction elongation is 5 ~ 7%, and longitudinal tensile strain rate is 12 ~ 25%.
The invention has the beneficial effects as follows that medical bandage of the present invention take base polyurethane prepolymer for use as resin matrix, inorganic nano-particle is functive, by described preparation method, prepare the polyurethane resin performed polymer medical bandage with bactericidal antiphlogistic, Promotive union, and this medical bandage intensity is high, good permeability, quality are light, glossiness good, be easy to plasticity, there is effect of excellent bactericidal antiphlogistic, analgesia, Promotive union, existing AGMA product on market can be substituted completely; And preparation method's environmental protection of the present invention, omnidistance pollution-free, raw material availability nearly 100%, preparation process is simple, low for equipment requirements, saves production cost, is applicable to industrialization large-scale production.
Detailed description of the invention
The present invention is described in further detail below, can implement according to this with reference to description word to make those skilled in the art.
The present invention discloses a kind of preparation method being coated with the medical bandage of polyurethane resin performed polymer, comprise the following steps: a, the preparation of base polyurethane prepolymer for use as: the aromatic diisocyanate adding 50 ~ 65 parts in three mouthfuls of reactors, the dehydrating agent of 0.1 ~ 1 part, stir at ambient temperature after 20 minutes, add the polyether Glycols of 20 ~ 30 parts again, the polyether-tribasic alcohol of 2 ~ 5 parts, the high molecular weight polyethylene glycol of 5 ~ 15 parts, the defoamer of 2 ~ 4 parts, the white carbon of 5 ~ 10 parts, the lubricant of 1 ~ 5 part, the catalyst of 1 ~ 2 part, slowly be warming up to 75 DEG C, be incubated 1.5 hours, then room temperature is down to, then obtain base polyurethane prepolymer for use as, the preparation of b, functive powder: pulverous nanometer particle, zinc oxide, far-infrared emission material are added in absolute ethyl alcohol and coupling agent solution, 70 DEG C are fully stirred 3 ~ 4 hours, and 80 DEG C of dryings 5 hours, grind, then obtain functive powder, the preparation of c, polyurethane resin performed polymer: according to 15% of the mass fraction of base polyurethane prepolymer for use as resin, joins in base polyurethane prepolymer for use as by functive powder, fully stirs 1 ~ 2 hour, then obtain polyurethane resin performed polymer under nitrogen protection condition, the preparation of d, medical bandage: under the condition of air humidity lower than 10%, employing twin-roll applies, polyurethane resin performed polymer is evenly coated in Ji Bushang, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the medical bandage being coated with polyurethane resin performed polymer.
Preferably, in described step a, aromatic diisocyanate is one or more in MDI, TDI, NDI; Dehydrating agent is one or more in maleic anhydride, chlorobenzoyl chloride, pyrovinic acid; Polyether Glycols is one or more in PEG or PPG of 300 ~ 6000 of molecular weight; Lubricant is silicone oil or polyethylene glycol oxide; Defoamer is one or more in silicone oil, calcium oxide, calcium hydroxide, molecular sieve; Catalyst is one or more in potassium oleate, triethylene diamine, four ethene triamines, two morpholine ethylether, dibutyl tin laurate.
Preferably, in described step b, nanometer particle is the one in silver nanoparticle level particle, copper nanometer particle, zinc oxide nano meter level particle, tourmaline nanometer particle.
Preferably, in described steps d, described Ji Bu is polyester or terylene, and Unit Weight is 80 ~ 130g/m, and cross direction elongation is 5 ~ 7%, and longitudinal tensile strain rate is 12 ~ 25%.
Specifically tell about the preparation method being coated with the medical bandage of polyurethane resin performed polymer of the present invention below.
Embodiment 1:
Will containing MDI vulcabond 1000g, chlorobenzoyl chloride 15g, add successively with thermometer, in the reactor of agitator and nitrogen inlet-outlet, abundant stirring 20min, add polypropylene oxide ether glycol 750g, its molecular weight is 2000, polypropylene oxide ether trihydroxylic alcohol 250g, its molecular weight is 300, add polyethylene glycol 100g, its molecular weight is 6000, slowly be warming up to 75 DEG C, insulation 1.5h, be cooled to room temperature, add polyethylene glycol oxide 50g, nanoscale calcium 50g, nano-scale white carbon black 150g, stirred under nitrogen atmosphere 1h, make base polyurethane prepolymer for use as stand-by, by nanometer-level silver particle, zinc oxide particles, TiO 2 particles, fluorite particle is by waiting mass ratio mixing, amount to 80g, add with condensing reflux, in the reactor of mechanical stirring device, add absolute ethyl alcohol 100g successively, silane coupler 20g, PVP 5g, its molecular weight is 4000, control temperature 70 DEG C, mechanical agitation 3 ~ 4h, discharging during near room temperature, and 5h is dried at 80 DEG C, grind into powder, drop in base polyurethane prepolymer for use as, and add 90g silicone coupling agents, abundant stirring 2h, obtained have bactericidal antiphlogistic analgesia Promotive union polyurethane resin performed polymer composite, 30 ~ 40 DEG C of temperature, under nitrogen protection condition, adopt roller coating technology, this polyurethane resin performed polymer composite is evenly coated on Ji Bushang, through rolling, shearing, vacuum, packaging, makes multifunction green environment protection medical bandage.
Embodiment 2:
Will containing TDI vulcabond 1000g, chlorobenzoyl chloride 20g, add in the reactor with thermometer, agitator and nitrogen inlet-outlet successively, abundant stirring 20min, adds Macrogol 600 g, and its molecular weight is 1000, polypropylene oxide ether trihydroxylic alcohol 300g, its molecular weight is 600, adds Macrogol 200 g, and its molecular weight is 6000, slowly be warming up to 75 DEG C, insulation 1.5h, is cooled to room temperature, adds polyethylene glycol oxide 50g, nano-class molecular sieve 60g, nano-scale white carbon black 100g, stirred under nitrogen atmosphere 1h, makes base polyurethane prepolymer for use as stand-by, by nanosized copper particle, zinc oxide particles, TiO 2 particles, tourmaline particle in etc. quality 2:1:1:1:1 ratio mixing, 70g altogether, add with condensing reflux, in the reactor of mechanical stirring device, add absolute ethyl alcohol 100g successively, silane coupler 20g, PVP 5g, its molecular weight is 4000, control temperature 70 DEG C, mechanical agitation 3 ~ 4h, discharging during near room temperature, and 5h is dried at 80 DEG C, grind into powder, drop in base polyurethane prepolymer for use as, and add 80g silicone coupling agents, abundant stirring 2h, obtained have bactericidal antiphlogistic analgesia Promotive union polyurethane resin performed polymer composite, at 30 ~ 40 DEG C of temperature, under nitrogen protection condition, adopt roller coating technology, this polyurethane resin performed polymer composite is evenly coated on Ji Bushang, through rolling, shearing, vacuum, packaging, makes multifunction green environment protection medical bandage.
Embodiment 3:
Will containing the mass mixings such as MDI and TDI vulcabond 900g altogether, maleic anhydride 10g, add successively with thermometer, in the reactor of agitator and nitrogen inlet-outlet, abundant stirring 20min, add polypropylene oxide ether glycol 500g, its molecular weight is 1000, polypropylene oxide ether trihydroxylic alcohol 200g, its molecular weight is 300, add polyethylene glycol 70g, its molecular weight is 6000, slowly be warming up to 75 DEG C, insulation 1.5h, be cooled to room temperature, add froth breaking silicone oil 50g, nanoscale calcium 50g, nanometer grade calcium carbonate 120g, stirred under nitrogen atmosphere 1h, make base polyurethane prepolymer for use as stand-by, by Nano titanium dioxide, zinc oxide particles, lithium niobate, tourmaline is by waiting mass ratio mixing, 110g altogether, add with condensing reflux, in the reactor of mechanical stirring device, add absolute ethyl alcohol 120g successively, silane coupler 30g, PVP 8g, its molecular weight is 4000, control temperature is at 70 DEG C, mechanical agitation 3 ~ 4h, discharging during near room temperature, and 5h is dried at 80 DEG C, grind into powder, drop in base polyurethane prepolymer for use as, and add 60g silicone coupling agents, abundant stirring 2h, obtained have bactericidal antiphlogistic analgesia Promotive union polyurethane resin performed polymer composite, at 30 ~ 40 DEG C of temperature, under nitrogen protection condition, adopt roller coating technology, this polyurethane resin performed polymer composite is evenly coated on Ji Bushang, through rolling, shearing, vacuum, packaging, makes multifunction green environment protection medical bandage.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the universal that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the embodiment described.
Claims (4)
1. be coated with a preparation method for the medical bandage of polyurethane resin performed polymer, it is characterized in that, comprise the following steps:
The preparation of a, base polyurethane prepolymer for use as: add the aromatic diisocyanate of 50 ~ 65 parts, the dehydrating agent of 0.1 ~ 1 part in three mouthfuls of reactors, stir at ambient temperature after 20 minutes, add the polyether Glycols of 20 ~ 30 parts, the polyether-tribasic alcohol of 2 ~ 5 parts, the high molecular weight polyethylene glycol of 5 ~ 15 parts, the defoamer of 2 ~ 4 parts, the white carbon of 5 ~ 10 parts, the lubricant of 1 ~ 5 part, the catalyst of 1 ~ 2 part again, slowly be warming up to 75 DEG C, be incubated 1.5 hours, then be down to room temperature, then obtain base polyurethane prepolymer for use as;
The preparation of b, functive powder: pulverous nanometer particle, zinc oxide, far-infrared emission material are added in absolute ethyl alcohol and coupling agent solution, 70 DEG C are fully stirred 3 ~ 4 hours, and 80 DEG C of dryings 5 hours, grind, then obtain functive powder;
The preparation of c, polyurethane resin performed polymer: according to 15% of the mass fraction of base polyurethane prepolymer for use as resin, joins in base polyurethane prepolymer for use as by functive powder, fully stirs 1 ~ 2 hour, then obtain polyurethane resin performed polymer under nitrogen protection condition;
The preparation of d, medical bandage: under the condition of air humidity lower than 10%, employing twin-roll applies, polyurethane resin performed polymer is evenly coated in Ji Bushang, through work feed, roll-in, rolling, shearing, sealing, packed, obtains the medical bandage being coated with polyurethane resin performed polymer.
2. the preparation method being coated with the medical bandage of polyurethane resin performed polymer according to claim 1, is characterized in that: in described step a, aromatic diisocyanate is one or more in MDI, TDI, NDI; Dehydrating agent is one or more in maleic anhydride, chlorobenzoyl chloride, pyrovinic acid; Polyether Glycols is one or more in PEG or PPG of 300 ~ 6000 of molecular weight; Lubricant is silicone oil or polyethylene glycol oxide; Defoamer is one or more in silicone oil, calcium oxide, calcium hydroxide, molecular sieve; Catalyst is one or more in potassium oleate, triethylene diamine, four ethene triamines, two morpholine ethylether, dibutyl tin laurate.
3. the preparation method being coated with the medical bandage of polyurethane resin performed polymer according to claim 1, it is characterized in that: in described step b, nanometer particle is the one in silver nanoparticle level particle, copper nanometer particle, zinc oxide nano meter level particle, tourmaline nanometer particle.
4. the preparation method being coated with the medical bandage of polyurethane resin performed polymer according to claim 1, it is characterized in that: in described steps d, described Ji Bu is polyester or terylene, and Unit Weight is 80 ~ 130g/m, cross direction elongation is 5 ~ 7%, and longitudinal tensile strain rate is 12 ~ 25%.
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| CN105497962A (en) * | 2015-12-28 | 2016-04-20 | 王书美 | Medical bandage having bactericidal and itching-relieving function and preparation method |
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| CN113152115A (en) * | 2021-04-22 | 2021-07-23 | 宁波因天之序生物科技有限公司 | Medical orthopedic bandage and preparation method thereof |
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