CN107496443A - A kind of manufacture anti-inflammatory of the protium powder containing sustained release and the method for the external application patch that eases pain - Google Patents
A kind of manufacture anti-inflammatory of the protium powder containing sustained release and the method for the external application patch that eases pain Download PDFInfo
- Publication number
- CN107496443A CN107496443A CN201710905825.1A CN201710905825A CN107496443A CN 107496443 A CN107496443 A CN 107496443A CN 201710905825 A CN201710905825 A CN 201710905825A CN 107496443 A CN107496443 A CN 107496443A
- Authority
- CN
- China
- Prior art keywords
- calcium carbonate
- precipitated calcium
- protium
- powder
- inflammatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
Abstract
A kind of method that the present invention discloses manufacture anti-inflammatory of the protium powder containing sustained release and the external application patch that eases pain, comprises the following steps：1) 1~5 μm of precipitated calcium carbonate of particle diameter and hydrogen compound are chosen as raw material；2) above-mentioned precipitated calcium carbonate is subjected to once pressurization, heat treatment using subcritical hydrolysis equipment；3) hydrogen compound will be added in the precipitated calcium carbonate after once pressurization, heat treatment using subcritical hydrolysis equipment and carry out secondary pressurized, heat treatment, obtain the precipitated calcium carbonate containing abundant protium；4) gel base is mixed to get in proportion using electrolyzed alkaline water and methylcellulose；5) obtain being sustained precipitated calcium carbonate hydrogen powder anti-inflammatory and analgesia external application cream after mixing the precipitated calcium carbonate containing abundant protium and gel base in proportion；6) this external application cream is used for such as injury gained in sports, lumbar muscle strain, the anti-inflammatory and analgesia of arthritis, local nerve pain, cervical spondylopathy, varication.
Description
Technical field
The present invention relates to anti-inflammatory and the field of analgesia external application cream, the more particularly to a kind of powder of the protium containing sustained release manufacture anti-inflammatory and
The method of analgesia external application patch.
Background technology
The research of the multinational medical field in the world was it has been shown that hydrogen had significantly to aoxidizing too drastic caused various diseases in recent years
Therapeutic effect, in existing more than 1000 of the report of pertinent literature all over the world, particularly Japan, sucked by hydrogen, take and contain
Hydrogen health products, hydrogeneous beverage and external application hydrogen lotion are drunk, numerous difficult patients has been broken away from the pain of disease.Hydrogen molecule is member
Minimum molecule in element, it can pass easily through biomembrane and play its oxidation resistance by skin rapid osmotic in vivo,
Hydrogen ion while hydroxyl radical free radical, improves human body cell ATP growing amount in purification body.Injury gained in sports, lumbar muscle strain, pass
The diseases such as inflammation, local nerve pain, cervical spondylopathy are saved, hydrogen molecule purifies the hydroxyl in affected part by skin rapid osmotic to affected part, hydrogen molecule
Base free radical, cytoactive is improved, reaches anti-inflammatory and analgesic purpose.
The content of the invention
A kind of method that the present invention discloses manufacture anti-inflammatory of the protium powder containing sustained release and the external application patch that eases pain, specific steps are such as
Under：
1st, using precipitated calcium carbonate and hydrogen compound as raw material, the average grain diameter requirement of precipitated calcium carbonate is 1~5 μ
M, specific surface area requirement is 0.5~2.5m2/ g, purity more than 99.5.Select hydrogen compound of the molecular weight below 400, such as molecule
Ethanol, polyethylene glycol, citric acid, malic acid, the monosaccharide and disaccharide etc. of amount less than 400, above-mentioned one or two can be selected during use
It is made above go out hydrogen compound solution, the concentration of hydrogen compound solution is 0.2~0.6mol/L.
2nd, using G-8 international trading M Co., Ltd. RM subcritical hydrolysis equipment, by above-mentioned lightweight carbon
Sour calcium carries out once pressurization, heat treatment, and subcritical hydrolysis device temperature is 180~220 DEG C, pressure 2.7MPa, adds moisture
It is 40~60 minutes to solve the time.After hydrolyzable terminates, pressure relief, vapor is released, temperature adjustment is 40~50 DEG C, is dried
30~40 minutes, the precipitated calcium carbonate after being hydrolyzed dried powder.
Precipitated calcium carbonate is in the how empty matter state of nanoscale in itself, organic matter or other impurities unavoidably be present in space, passes through
After above-mentioned subcritical hydrolysis equipment pressurization, heat treatment, organic matter or other impurities in space are decomposed, and organic matter is decomposed
While discharge a certain amount of hydrogen, hydrogen is stranded in nanovoids in a high voltage state.
3rd, hydrogen compound solution, such as molecular weight are prepared after hydrogen compound of the molecular weight below 400 is dissolved using ethanol
Less than 400 polyethylene glycol, citric acid, malic acid, monosaccharide and disaccharide etc., above-mentioned one or more kinds of systems can be selected during use
For hydrogen compound solution is gone out, the concentration of hydrogen compound solution is 0.2~0.6mol/L.
4th, the precipitated calcium carbonate powder after a subcritical hydrolysis is handled is soaked in hydrogen compound solution, and immersion 30~
De- liquid processing is carried out after 60 minutes, it is desirable to which maintenance dose of the hydrogen compound solution in precipitated calcium carbonate powder is precipitated calcium carbonate powder
Body weight than 50~80%.Precipitated calcium carbonate powder after immersing liquid reuses G-8 international
Trading M Co., Ltd. RM subcritical hydrolysis equipment carries out secondary hydrolysis process, and the subcritical hydrolysis device temperature used is
200~220 DEG C, pressure 2.7MPa, the hydrolyzable time is 30~50 minutes.After hydrolyzable terminates, pressure relief, release
Vapor, temperature adjustment are 40~50 DEG C, are dried 30~40 minutes, obtain the precipitated calcium carbonate xeraphium containing abundant protium
Body.
After precipitated calcium carbonate powder is soaked in hydrogen compound solution, the active ingredient of hydrogen compound is permeated in precipitated calcium carbonate
Space in, reuse after subcritical hydrolysis equipment carries out secondary hydrolysis process, the hydrogen compound in space is decomposed, and decomposes
While discharge substantial amounts of hydrogen, hydrogen is stranded in nanovoids in a high voltage state, further increases hydrogen in space
The content of element, protium storing in nanovoids are relatively stable.
The above-mentioned precipitated calcium carbonate drying powders of 1g and 1 drop hydrogenase liquid is taken to be put into 500ml running water, after 5 minutes certainly
Water ORP (oxidation-reduction potential) is -680mV, and pH is 8.20, and the μ L of hydrogen 35 are contained in the volatilization gas of collection.Before detection originally
Water ORP (oxidation-reduction potential) is 750mV, and pH is 7.20.The above-mentioned precipitated calcium carbonate of description of test is dried after powder meets water and produced
Substantial amounts of negative hydrogen ion and electronics so that the ORP of running water turns into negativity by positivity, and pH value is partial to alkalescence.
5th, using electrolysis wetting system, 15% K is utilized2CO3(potassium carbonate) aqueous solution as electrolyte, prepare pH8.5~
9.0th, ORP (oxidation-reduction potential) -690~-780mV electrolyzed alkaline water.
6th, it is 30.0%~32.0% that methylcellulose, which requires that dry product contains methoxyl group (- OCH3), and viscosity (20 DEG C, 2% water
Solution) 50~3000mPa.s.Methylcellulose is dissolved in aforementioned base electrolysis water, concentration is 2~5%, is stirred 3~5 minutes
After obtain gel base, preserved in sealed insulation container.
The gel base prepared using above-mentioned electrolysis water, due to containing abundant electronics (e in electrolysis water-), it is molten deposit hydrogen and
Potassium ion (K+), the further analgesia for improving lotion and anti-inflammatory effect.To prevent electronics from revealing, containers demand insulation.
7th, according to affected part size, gel base is uniformly applied on non-permeable textile, then is uniformly sprinkled containing rich
The precipitated calcium carbonate powder of hydrogen-rich element, the precipitated calcium carbonate lotion patch containing abundant protium is obtained after being sufficiently mixed, is coagulated
Gum base materials and the weight of powder ratio are 8: 2, lotion are spread on into affected part, outside is sealed using aluminium-foil paper.According to the feelings in affected part
Condition, the precipitated calcium carbonate lotion containing abundant protium daily use 1~2 time, 40~50 minutes every time, for injury gained in sports,
The treatment of the diseases such as lumbar muscle strain, arthritis, local nerve pain, cervical spondylopathy.
After precipitated calcium carbonate powder containing abundant protium mixes with gel base, lotion starts slowly to discharge hydrogen,
To prevent hydrogen from outwards volatilizing, the aluminium-foil paper that outer layer has sealant tape using four sidebands is sealed, and reaches the protium of sustained release
Permeate completely in affected part.Protium has very strong anti-oxidant and bacteriostasis, is that need not add preservative etc. in this lotion to add
Add agent.
Embodiment
In order that the purpose of the present invention, technical scheme are clearer, the preferred embodiments of the present invention will be carried out below in detail
Thin description.
Embodiment 1
The average grain diameter of precipitated calcium carbonate is 1~5 μm, and specific surface area is 0.5~2.5m2/ g, purity more than 99.5.Asia is faced
Boundary's hydrolysis device temperature is 220 DEG C, pressure 2.7MPa, 60 minutes hydrolyzable time.Precipitated calcium carbonate hydrolyzable terminates
Afterwards, pressure relief, vapor is released, temperature adjustment is 50 DEG C, is dried 40 minutes, the precipitated calcium carbonate xeraphium after being hydrolyzed
Body.Hydrogen compound solution will be prepared after citric acid of the molecular weight below 400 and the dissolving of malic acid equivalent using ethanol, hydrogenation is closed
The concentration of thing solution is 0.6mol/L.It is molten that precipitated calcium carbonate powder after subcritical hydrolysis is handled is soaked in hydrogen compound
In liquid, immersion carries out de- liquid processing after 60 minutes, it is desirable to which maintenance dose of the hydrogen compound solution in precipitated calcium carbonate powder is light
Matter Paris white body weight than 80%.Precipitated calcium carbonate powder after immersing liquid reuses the progress of subcritical hydrolysis equipment
Secondary hydrolysis process, the subcritical hydrolysis device temperature used are 220 DEG C, pressure 2.7MPa, and the hydrolyzable time is 50 points
Clock.After hydrolyzable terminates, pressure relief, vapor is released, temperature adjustment is 50 DEG C, dries 40 minutes, obtains containing abundant
The precipitated calcium carbonate of protium dries powder.
Using electrolysis wetting system, 15% K is utilized2CO3(potassium carbonate) aqueous solution as electrolyte, prepare pH9.0 (±
0.2), ORP (oxidation-reduction potential) ＞ -780mV electrolyzed alkaline water.
It is 32.0% that methylcellulose, which requires that dry product contains methoxyl group (- OCH3), viscosity (20 DEG C, 2% aqueous solution) 50~
3000mPa.s.Methylcellulose is dissolved in aforementioned base electrolysis water, concentration 5%, stirring obtains gel base after 5 minutes,
Preserved in sealed insulation container.
Outer layer has the aluminium-foil paper of sealant tape using 15cm × 10cm, four sidebands, and inner side uses double faced adhesive tape by 13cm × 8cm
Non-permeable sterile non-woven fabrics be fixed on aluminium-foil paper central portion, gel base is uniformly applied on non-permeable textile,
The precipitated calcium carbonate powder containing abundant protium is uniformly sprinkled again, gel base 8g, powder 2g, is contained after being sufficiently mixed
The precipitated calcium carbonate lotion patch of abundant protium, affected part is spread on by lotion, sealed around.Lightweight carbon containing abundant protium
Sour calcium lotion uses 1~2 time daily, and 40~50 minutes every time, this external application cream was used for such as injury gained in sports, lumbar muscle strain, joint
The anti-inflammatory and analgesia of inflammation, local nerve pain, cervical spondylopathy etc..
Embodiment 2
The average grain diameter of precipitated calcium carbonate is 1~5 μm, and specific surface area is 0.5~2.5m2/ g, purity more than 99.5.Asia is faced
Boundary's hydrolysis device temperature is 180 DEG C, pressure 2.7MPa, 40 minutes hydrolyzable time.Precipitated calcium carbonate hydrolyzable terminates
Afterwards, pressure relief, vapor is released, temperature adjustment is 40 DEG C, is dried 30 minutes, the precipitated calcium carbonate xeraphium after being hydrolyzed
Body.Hydrogen compound solution, the concentration of hydrogen compound solution are prepared after citric acid of the molecular weight below 400 is dissolved using ethanol
For 0.2mol/L.Precipitated calcium carbonate powder after subcritical hydrolysis is handled is soaked in hydrogen compound solution, immersion 30
De- liquid processing is carried out after minute, it is desirable to which maintenance dose of the hydrogen compound solution in precipitated calcium carbonate powder is precipitated calcium carbonate powder
Weight than 50%.Precipitated calcium carbonate powder after immersing liquid reuses subcritical hydrolysis equipment and carried out at secondary hydrolysis
Reason, the subcritical hydrolysis device temperature used are 200 DEG C, pressure 2.7MPa, and the hydrolyzable time is 30 minutes.Hydrolyzable
After end, pressure relief, vapor is released, temperature adjustment is 40 DEG C, is dried 30 minutes, obtains the lightweight containing abundant protium
Calcium carbonate dries powder.
Using electrolysis wetting system, 15% K is utilized2CO3(potassium carbonate) aqueous solution as electrolyte, prepare pH8.5 (±
0.2), ORP (oxidation-reduction potential) ＞ -690mV electrolyzed alkaline water.
It is 32.0% that methylcellulose, which requires that dry product contains methoxyl group (- OCH3), viscosity (20 DEG C, 2% aqueous solution) 50~
3000mPa.s.Methylcellulose is dissolved in aforementioned base electrolysis water, concentration 3%, stirring obtains gel base after 5 minutes,
Preserved in sealed insulation container.
Outer layer has the aluminium-foil paper of sealant tape using 30cm × 15cm, four sidebands, inner side using double faced adhesive tape by 28cm ×
13cm non-permeable sterile non-woven fabrics is fixed on aluminium-foil paper central portion, and gel base is uniformly applied to non-permeable textile
On, then the precipitated calcium carbonate powder containing abundant protium is uniformly sprinkled, gel base 40g, powder 10g, obtained after being sufficiently mixed
To the precipitated calcium carbonate lotion patch containing abundant protium, lotion is spread on into affected part, it is sealed around..Contain abundant protium
Precipitated calcium carbonate lotion daily use 1~2 time, 40~50 minutes every time, this external application cream be used for improve Venous leg varicose
Symptom.
Claims (5)
1. a kind of manufacture anti-inflammatory of the protium powder containing sustained release and the method for the external application patch that eases pain, it is characterised in that comprise the following steps：
1) precipitated calcium carbonate, hydrogen compound, electrolyzed alkaline water and methylcellulose are used as raw material；
2) above-mentioned precipitated calcium carbonate is subjected to once pressurization, heat treatment using subcritical hydrolysis equipment, it is light after being hydrolyzed
Matter calcium carbonate dries powder；
3) the precipitated calcium carbonate powder after a subcritical hydrolysis is handled is soaked in hydrogen compound solution, the lightweight after immersion
Calcium carbonate powder reuses subcritical hydrolysis equipment progress secondary pressurized, heat treatment obtains the lightweight containing abundant protium
Calcium carbonate dries powder；
4) gel base is mixed to get in proportion using electrolyzed alkaline water and methylcellulose, by the lightweight containing abundant protium
Calcium carbonate and gel base obtain the precipitated calcium carbonate anti-inflammatory containing sustained release protium and analgesia external application cream after mixing in proportion.
2. a kind of method of the manufacture anti-inflammatory of the protium powder containing sustained release and the external application patch that eases pain in right 1, contained step 1)
Including：
1) the average grain diameter requirement of precipitated calcium carbonate is 1~5 μm, and specific surface area requirement is 0.5~2.0m2/ g, purity 99.5% with
On；
2) using ethanol by molecular weight below 400 hydrogen compound dissolving after prepare hydrogen compound solution, as molecular weight 400 with
Under polyethylene glycol, citric acid, malic acid, monosaccharide and disaccharide etc., above-mentioned one or more can be selected during use and prepare hydrogen
Compound solution, the concentration of hydrogen compound solution is 0.2~0.6mol/L；
3) using electrolysis wetting system, 15% K is utilized2CO3(potassium carbonate) aqueous solution as electrolyte, prepare pH8.5~9.0,
ORP (oxidation-reduction potential) 690~780mV electrolyzed alkaline water；
4) methylcellulose requires that dry product (- OCH3) containing methoxyl group should be 30.0%~32.0%, and (20 DEG C, 2% is water-soluble for viscosity
Liquid) 50~3000mPa.s.
3. a kind of method of the manufacture anti-inflammatory of the protium powder containing sustained release and the external application patch that eases pain in right 1, contained step 2)
Including：
1) G-8 international trading M Co., Ltd. RM subcritical hydrolysis equipment is used, temperature is 180~220
DEG C, pressure 2.7MPa, hydrolyzable is carried out to precipitated calcium carbonate, the time is 40~60 minutes；
2) after hydrolyzable terminates, pressure relief, vapor is released, temperature adjustment is 40~50 DEG C, dries 30~40 minutes, obtains
Precipitated calcium carbonate after to hydrolysis dries powder.
4. a kind of method of the manufacture anti-inflammatory of the protium powder containing sustained release and the external application patch that eases pain in right 1, contained step 3)
Including：
1) the precipitated calcium carbonate powder after a subcritical hydrolysis is handled is soaked in hydrogen compound solution, soaks 30~60 points
De- liquid processing is carried out after clock, it is desirable to which maintenance dose of the hydrogen compound solution in precipitated calcium carbonate powder is precipitated calcium carbonate powder weight
Measure the 50~80% of ratio；
2) the precipitated calcium carbonate powder after immersing liquid is reused using G-8 international trading Co., Ltd.
MRM subcritical hydrolysis equipment, carries out secondary hydrolysis process, and the subcritical hydrolysis device temperature used is 200~220 DEG C, pressure
For 2.7MPa, the hydrolyzable time is 30~50 minutes；
3) after hydrolyzable terminates, pressure relief, vapor is released, temperature adjustment is 40~50 DEG C, dries 30~40 minutes, obtains
Powder is dried to the precipitated calcium carbonate containing abundant protium.Aluminium foil bag is sealed immediately for obtained powder requirement；
4) above-mentioned precipitated calcium carbonate, which is dried in 1 gram of powder, contains the μ L of protium 10~40.
5. a kind of method of the manufacture anti-inflammatory of the protium powder containing sustained release and the external application patch that eases pain in right 1, contained step 4)
Including：
1) methylcellulose is dissolved in aforementioned base electrolysis water, concentration is 2~5%, and stirring obtains gel base after 3~5 minutes
Material, preserved in sealed insulation container；
2) according to affected part size, gel base is uniformly applied on non-permeable textile, then uniformly sprinkled containing abundant hydrogen
The precipitated calcium carbonate powder of element, the precipitated calcium carbonate lotion patch containing abundant protium, gel base are obtained after being sufficiently mixed
The weight of material and powder ratio is 8: 2, lotion is spread on into affected part, outside is sealed using aluminium-foil paper.According to the situation in affected part, contain
The precipitated calcium carbonate lotion for having abundant protium uses 1~2 time, every time 40~50 minutes daily.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710905825.1A CN107496443A (en) | 2017-09-29 | 2017-09-29 | A kind of manufacture anti-inflammatory of the protium powder containing sustained release and the method for the external application patch that eases pain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710905825.1A CN107496443A (en) | 2017-09-29 | 2017-09-29 | A kind of manufacture anti-inflammatory of the protium powder containing sustained release and the method for the external application patch that eases pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107496443A true CN107496443A (en) | 2017-12-22 |
Family
ID=60700179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710905825.1A Pending CN107496443A (en) | 2017-09-29 | 2017-09-29 | A kind of manufacture anti-inflammatory of the protium powder containing sustained release and the method for the external application patch that eases pain |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107496443A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330764A (en) * | 2018-08-24 | 2019-02-15 | 杭州氢源素生物科技有限公司 | A kind of hydrogen molecule fever Anti-inflammatory plaster and its application method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101917874A (en) * | 2007-11-22 | 2010-12-15 | 有限责任中间法人溶媒化学研究所 | The preparation method of coral powder |
| CN104230406A (en) * | 2013-06-06 | 2014-12-24 | 上海环垦生态科技有限公司 | Active micromolecular ecological nutrition agent and use method thereof |
-
2017
- 2017-09-29 CN CN201710905825.1A patent/CN107496443A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101917874A (en) * | 2007-11-22 | 2010-12-15 | 有限责任中间法人溶媒化学研究所 | The preparation method of coral powder |
| CN104230406A (en) * | 2013-06-06 | 2014-12-24 | 上海环垦生态科技有限公司 | Active micromolecular ecological nutrition agent and use method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 周毅，译: "气体疗法", 《世界科学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330764A (en) * | 2018-08-24 | 2019-02-15 | 杭州氢源素生物科技有限公司 | A kind of hydrogen molecule fever Anti-inflammatory plaster and its application method |
| CN109330764B (en) * | 2018-08-24 | 2020-11-24 | 杭州氢源素生物科技有限公司 | Hydrogen molecule heating anti-inflammation patch and use method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104264485B (en) | Preparation method of medical bandage coated with polyurethane resin prepolymer | |
| CN104307032B (en) | A kind of pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing | |
| KR101012289B1 (en) | Sheetless face mask using hydrogel and fabrication method thereof | |
| CN100581536C (en) | Camellia skin-care essence oil | |
| CN106362202A (en) | Hydrogel with microcurrent and medicine slow-release function and preparation method and application | |
| CN107693381A (en) | A kind of bar cloth veneer film containing flexible nano-liposomes | |
| CN109646712A (en) | A kind of sulikol liquid dressing and preparation method thereof | |
| CN107496443A (en) | A kind of manufacture anti-inflammatory of the protium powder containing sustained release and the method for the external application patch that eases pain | |
| CN104027300A (en) | Antibacterial chitosan gel and preparation method thereof | |
| CN201578439U (en) | Medicine storage reservoir scar removing silicon gel paster | |
| CN107648309A (en) | A kind of oral spray of swelling and pain relieving | |
| CN107802869A (en) | A kind of air purifying preparation for possessing purification disinfecting function | |
| CN101756941A (en) | Drug-reservoir type scar-removing silicone gel paster and preparation method thereof | |
| CN111248530A (en) | Agalloch eaglewood gauze mask | |
| CN106420681A (en) | Massaging gel capable of relieving muscle pain and preparing method thereof | |
| CN107028977A (en) | A kind of ozone carburetion complex compound and its preparation method and application | |
| CN103767910A (en) | Radix-gentiana rose skin moistening liquid | |
| CN109330764B (en) | Hydrogen molecule heating anti-inflammation patch and use method thereof | |
| CN101891291A (en) | Drinking water clarification disinfecting pills and preparation method | |
| CN107496341A (en) | A kind of manufacture method of the coral calcium facial mask of use protium containing sustained release | |
| CN104415024B (en) | Cataplasm containing Diclofenac, and combinations thereof and preparation method | |
| CN106075538A (en) | Adhesion protective oil sliver and manufacture craft thereof | |
| CN104984385B (en) | A kind of pre- stick of water soluble medical | |
| CN104382998A (en) | Carbomer gel and preparation method thereof | |
| CN103408543A (en) | High purity citric acid and navoban compound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171222 |
|
| WD01 | Invention patent application deemed withdrawn after publication |