CN101756941A - Drug-reservoir type scar-removing silicone gel paster and preparation method thereof - Google Patents
Drug-reservoir type scar-removing silicone gel paster and preparation method thereof Download PDFInfo
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- CN101756941A CN101756941A CN200910266687A CN200910266687A CN101756941A CN 101756941 A CN101756941 A CN 101756941A CN 200910266687 A CN200910266687 A CN 200910266687A CN 200910266687 A CN200910266687 A CN 200910266687A CN 101756941 A CN101756941 A CN 101756941A
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Abstract
The invention relates to a drug-reservoir type scar-removing silicone gel paster and a preparation method thereof. The drug-reservoir type scar-removing silicone gel paster is characterized by comprising a silicone membrane and a silicone gel layer, wherein a drug reservoir is arranged in the silicone gel layer, and the inner part of the drug reservoir contains drugs and organic silicon polymer mixed liquid. The drug reservoir is directly arranged in the silicone gel layer, so the drug-reservoir type scar-removing silicone gel paster solves the problem that active ingredients in the drugs are isolated by the silicone membrane to cause macromolecular drugs to difficultly penetrate. The drugs in the drug-reservoir can better penetrate the silicone gel layer and play a role of treatment for scars, so that the paster shortens the treatment cycle and increases the treatment effect for the scars. In addition, the drug-reservoir type scar-removing silicone gel paster has simple preparation method, does not need complex molding equipment and is easy to produce and operate.
Description
Technical field
The present invention relates to a kind of medical paster and preparation method thereof, especially relate to a kind of drug-reservoir type scar-removing silicone sticker sheet and preparation method thereof.
Background technology
Wound, surgical wound, burn can stay cicatrix unavoidably behind human body wound surface place wound healing, wherein hypertrophic cicatrix and keloid particularly influence the outward appearance beauty treatment.After discovery silicon gels such as nineteen eighty-two Perkins have the effect of softening cicatrix, the various countries scholar has carried out a large amount of research, proof silicone product really can play preventive and therapeutic effect and invent a lot of medical silicone products cicatrix, but most widely used be silicone gel paster.The material of silicone gel paster itself is highly purified medical silica-gel, there is not any medicine adding ingredient, simple silicon gel has good preventing and therapeutical effect to hypertrophic cicatrix, but treatment cycle is longer, generally need more than 3 months, and silicone gel paster itself softens cicatrix and smooths effect obviously, but does not have obvious desalination effect for the pigment sedimentation of cicatrix itself.
At the problems referred to above, relevant producer is filled in medicine in the subsides of silicon gel cicatrix.Such as the patent No. of Shanghai Dong Yue Medical Health Product Co., Ltd be 03115384.4, name is called the patent of " preparation methoies that the reinforced cicatrix of fill-type pastes ", its principal character is to sew up with fluid sealant around two pellosils, stay place's opening as filling mouth, the reuse syringe injects the liquid organosilicon polymer or contains between liquid organosilicon polymer to two pellosil of medicine, to fill mouthful sealing then, at last with the silicon gel coating on lower floor's pellosil as the stickup skin layer.Its processing technology is comparatively complicated, and its pastille packed layer in fact and between the silicon gel also at interval one deck pellosil, macromolecular drug is not easy to be penetrated into silicon gel layer by pellosil, thus influence is to the therapeutic effect and the treatment cycle of cicatrix.
Summary of the invention
The applicant has carried out research and has improved at above-mentioned problem, and a kind of drug-reservoir type scar-removing silicone gel paster is provided, and shorten treatment cycle and the raising therapeutic effect to cicatrix, and its preparation method is simple, need not complicated former, is easy to production operation.
In order to solve the problems of the technologies described above, the present invention adopts following technical scheme:
A kind of drug-reservoir type scar-removing silicone gel paster comprises pellosil and silicon gel layer, is provided with drug storage warehouse in the described silicon gel layer, holds medicine and organosilicon polymer mixed liquor in the described drug storage warehouse.
Further:
The thickness of described silicon gel layer is between the 1.0-4.0 millimeter.
Described medicine is corticosteroid medication, activating blood and removing stasis drug, heat-clearing and toxic substances removing medicine, antalgesic-antipruritic detumescence medicine or YIN nourishing skin care medicine.
Described organosilicon polymer is methyl polysiloxane, vinyl polysiloxanes or silicon hydrogen based polysiloxane.
A kind of preparation method of drug-reservoir type scar-removing silicone gel paster may further comprise the steps:
A, pellosil is made into predetermined size and as bottom;
B, uncured silicon gel is applied one deck earlier on pellosil, its thickness and places baking oven to make silicon gel semi-solid preparation between the 0.3-1.0 millimeter;
C, medicine is added in the liquid organosilicon polymer, stirring becomes medicine organosilicon polymer mixed liquor;
D, with the medicine organosilicon polymer mixed liquor addition as required that mixes, drop in the central authorities of the silicon gel of semi-solid preparation;
E, with uncured silicon gel coating in above-mentioned steps D on semi-solid preparation silicon gel and the medicine organosilicon polymer mixed liquor, medicine organosilicon polymer mixed liquor is embedded in the silicon gel and forms the drug storage warehouse of medicine organosilicon polymer mixed liquor in silicon gel layer, and the gross thickness of silicon gel layer is between the 1.0-4.0 millimeter;
F, place baking oven to make silicon gel full solidification, and be attached to outside the silicon gel layer with antiadhesion barrier;
G, deburring, check and packing.
Constitute in the medicine organosilicon polymer mixed liquor of drug storage warehouse of the present invention, organosilicon polymer as matrix can be methyl polysiloxane, vinyl polysiloxanes, silicon hydrogen based polysiloxane or other organosilicon macromolecule materials of viscosity higher, wherein also can add a spot of fumed silica, its objective is to make the high-viscosity organosilicon polymer have certain thixotropy.Various volatility or non-volatility medicine, various Chinese medicine extract, extracting solution, Chinese medicine fluid extract, plants essential oil, plant extraction liquid and powdered drug become to grade and all can sneak in the liquid organosilicon polymer, and the collocation of medicine adding ingredient and addition can be decided according to the actual therapeutic needs.Medicine organosilicon polymer mixed liquor can be a successive big liquid group at silicon gel layer, forms the drug storage warehouse of a configuration; Also can be discontinuous, not of uniform size, different drop, form the drug storage warehouse of Discrete Distribution; Two kinds of forms are identical for the effect of treatment.In preparation process, temperature of oven and solidified time can decide according to the actual silicon gel formula, and its main purpose is that the silicon gel is lost flowability and semi-solid preparation or curing.
Technique effect of the present invention is:
A kind of drug-reservoir type scar-removing silicone gel paster disclosed by the invention, its drug storage warehouse is set directly in the silicon gel layer, the problem of having avoided effective ingredient to be isolated and having made macromolecular drug be difficult to permeate by pellosil, medicine in the drug storage warehouse can penetrate silicon gel layer preferably and cicatrix is played therapeutical effect, shortens treatment cycle and the raising therapeutic effect to cicatrix; In addition, the drug-reservoir type scar-removing silicone gel paster preparation method is simple, need not complicated former, is easy to production operation.
Description of drawings
Fig. 1 is a front view of the present invention.
Fig. 2 is the vertical view of Fig. 1.
Fig. 3 is the structural representation of the present invention of discrete shape for drug storage warehouse.
Fig. 4 is the vertical view of Fig. 3.
The specific embodiment
Below in conjunction with accompanying drawing the specific embodiment of the present invention is described in further detail.
As shown in Figure 1, 2, a kind of drug-reservoir type scar-removing silicone gel paster disclosed by the invention, comprise pellosil 1 and silicon gel layer 2, pellosil 1 is bonded together with silicon gel layer 2, be provided with drug storage warehouse 3 in the silicon gel layer 2, hold medicine and organosilicon polymer mixed liquor in the drug storage warehouse 3, the preferred thickness of silicon gel layer 2 is between the 1.0-4.0 millimeter, and silicon gel layer 2 adopts medical room temperature vulcanized silicon gel.Medicine wherein is according to different therapeutic purposes, can be the compositions of corticosteroid medication, activating blood and removing stasis drug, heat-clearing and toxic substances removing medicine, antalgesic-antipruritic detumescence medicine, YIN nourishing skin care medicine or certain several medicine, organosilicon polymer can be selected methyl polysiloxane, vinyl polysiloxanes or silicon hydrogen based polysiloxane etc. for use.Because hold the viscosity and the mobile difference of medicine organosilicon polymer mixed liquor in the drug storage warehouse 3, in preparation process, drug storage warehouse 3 is the form (as Fig. 1, Fig. 2) of an integral body or the state (as Fig. 3, Fig. 4) that is in a discrete distribution.In use, the adhesive paste by silicon gel layer 2 itself on skin, the effect of cicatrix being played treatment and smoothing and desalinate pigment by the infiltration of silicon gel and medicine.
The preparation method embodiment of drug-reservoir type scar-removing silicone gel paster
Step is as follows:
A, the pellosil of 0.15 millimeters thick made become 50 * 60 millimeters and as bottom;
B, uncured silicon gel is evenly applied one deck earlier on pellosil, about 0.5 millimeter of its thickness, and place 100 ℃ of baking ovens to take out after 2 minutes, and the silicon gel is the semi-solid preparation shape at this moment, and the silicon gel itself loses flowability;
C, will account for total amount 3% Asiaticoside, 2% Herba Lysimachiae foenum-graeci quintessence oil, 2% Rosehips quintessence oil and add in the methyl polysiloxane that viscosity is 300000cp (25 ℃) and stir and become medicine organosilicon polymer mixed liquor, vacuum is taken out the bubble that degass;
D, get medicine organosilicon polymer mixed liquor 2 gram of step C, drop in the central authorities of the silicon gel of semi-solid preparation;
E, with uncured silicon gel coating in above-mentioned steps D on semi-solid preparation silicon gel and the medicine organosilicon polymer mixed liquor, medicine organosilicon polymer mixed liquor is embedded in the silicon gel and forms the drug storage warehouse 3 of medicine organosilicon polymer mixed liquor in silicon gel layer, and the gross thickness of silicon gel layer 2 is about 2 millimeters;
F, place the sulfuration of 50 ℃ of baking ovens to make silicon gel full solidification in 40 minutes, and be attached to outside the silicon gel layer with antiadhesion barrier;
G, deburring, check and packing.
Drug-reservoir type scar-removing silicone gel paster by the above-mentioned steps preparation is used for the treatment of hypertrophic cicatrix and pigementation, and curative effect is good.
Claims (5)
1. a drug-reservoir type scar-removing silicone gel paster is characterized in that: comprise pellosil and silicon gel layer, be provided with drug storage warehouse in the described silicon gel layer, hold medicine and organosilicon polymer mixed liquor in the described drug storage warehouse.
2. according to the described drug-reservoir type scar-removing silicone gel paster of claim 1, it is characterized in that: the thickness of described silicon gel layer is between the 1.0-4.0 millimeter.
3. according to the described drug-reservoir type scar-removing silicone gel paster of claim 1, it is characterized in that: described medicine is corticosteroid medication, activating blood and removing stasis drug, heat-clearing and toxic substances removing medicine, antalgesic-antipruritic detumescence medicine or YIN nourishing skin care medicine.
4. according to the described drug-reservoir type scar-removing silicone gel paster of claim 1, it is characterized in that: described organosilicon polymer is methyl polysiloxane, vinyl polysiloxanes or silicon hydrogen based polysiloxane.
5. the preparation method of the described drug-reservoir type scar-removing silicone gel paster of claim 1 is characterized in that may further comprise the steps:
A, pellosil is made into predetermined size and as bottom;
B, uncured silicon gel is applied one deck earlier on pellosil, its thickness and places baking oven to make silicon gel semi-solid preparation between the 0.3-1.0 millimeter;
C, medicine is added in the liquid organosilicon polymer, stirring becomes medicine organosilicon polymer mixed liquor;
D, with the medicine organosilicon polymer mixed liquor addition as required that mixes, drop in the central authorities of the silicon gel of semi-solid preparation;
E, with uncured silicon gel coating in above-mentioned steps D on semi-solid preparation silicon gel and the medicine organosilicon polymer mixed liquor, medicine organosilicon polymer mixed liquor is embedded in the silicon gel and forms the drug storage warehouse of medicine organosilicon polymer mixed liquor in silicon gel layer, and the gross thickness of silicon gel layer is between the 1.0-4.0 millimeter;
F, place baking oven to make silicon gel full solidification, and be attached to outside the silicon gel layer with antiadhesion barrier;
G, deburring, check and packing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910266687A CN101756941A (en) | 2009-12-31 | 2009-12-31 | Drug-reservoir type scar-removing silicone gel paster and preparation method thereof |
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| CN200910266687A CN101756941A (en) | 2009-12-31 | 2009-12-31 | Drug-reservoir type scar-removing silicone gel paster and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716104A (en) * | 2012-06-25 | 2012-10-10 | 武汉纺织大学 | Medical organic silicon patch and preparation method thereof |
| CN105012990A (en) * | 2015-08-10 | 2015-11-04 | 南阳市汇博生物技术有限公司 | Ultra-thin soft poly silicone scar removing paste and making method |
| CN105287441A (en) * | 2015-11-17 | 2016-02-03 | 哈尔滨乾佰纳生物药业有限公司 | Silica gel scar treatment strip and preparation method thereof |
| CN108113801A (en) * | 2017-11-24 | 2018-06-05 | 上海纽帕化工有限公司 | A kind of scar plaster and preparation method thereof |
| CN113318094A (en) * | 2021-05-08 | 2021-08-31 | 广州贝昊医疗科技有限公司 | Silicone gel patch containing plant herbal components and manufacturing method thereof |
-
2009
- 2009-12-31 CN CN200910266687A patent/CN101756941A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716104A (en) * | 2012-06-25 | 2012-10-10 | 武汉纺织大学 | Medical organic silicon patch and preparation method thereof |
| CN102716104B (en) * | 2012-06-25 | 2014-05-14 | 武汉纺织大学 | Medical organic silicon patch and preparation method thereof |
| CN105012990A (en) * | 2015-08-10 | 2015-11-04 | 南阳市汇博生物技术有限公司 | Ultra-thin soft poly silicone scar removing paste and making method |
| CN105287441A (en) * | 2015-11-17 | 2016-02-03 | 哈尔滨乾佰纳生物药业有限公司 | Silica gel scar treatment strip and preparation method thereof |
| CN108113801A (en) * | 2017-11-24 | 2018-06-05 | 上海纽帕化工有限公司 | A kind of scar plaster and preparation method thereof |
| CN113318094A (en) * | 2021-05-08 | 2021-08-31 | 广州贝昊医疗科技有限公司 | Silicone gel patch containing plant herbal components and manufacturing method thereof |
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Application publication date: 20100630 |