CN101147798A - Galactophore paste and its preparing process - Google Patents
Galactophore paste and its preparing process Download PDFInfo
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- CN101147798A CN101147798A CNA2007101455076A CN200710145507A CN101147798A CN 101147798 A CN101147798 A CN 101147798A CN A2007101455076 A CNA2007101455076 A CN A2007101455076A CN 200710145507 A CN200710145507 A CN 200710145507A CN 101147798 A CN101147798 A CN 101147798A
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- rhizoma curcumae
- semen
- angelicae dahuricae
- radix
- radix angelicae
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Abstract
The present invention discloses a Chinese medicine adhesive plaster for external application for effectively curing mastopathy with obvious therapeutic effect. Said Chinese medicine adhesive plaster is made up by using 7 Chinese medicinal materials of zedoary, turmeric, garden balsam seed, semiaquilegia tuber, momordica seed, dahurian angelica root and honey through a certain preparation process.
Description
Technical field
The present invention relates to mastotic externally used paste of a kind of treatment and preparation method thereof.
Background technology
There is the drawback that Chinese medicine ingredients is many, cost is high, curative effect is bad in the mastotic Chinese medicine of existing treatment, and there is the drawback of complex procedures in prior preparation method.
Summary of the invention
The object of the present invention is to provide a kind of good effect, the simple galactophore paste of preparation section and preparation method thereof.
Galactophore paste comprises Rhizoma Curcumae, Rhizoma Curcumae Longae, Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae Six-element Chinese medicine, and the shared parts by weight of each Chinese medicine are respectively: Rhizoma Curcumae 153-187, Rhizoma Curcumae Longae 122-150, Semen Impatientis 122-150, Radix Semiaquilegiae 91.8-112.2, Semen Momordicae 30.6-37.4, Radix Angelicae Dahuricae 45.9-56.1.Its preparation method comprises: a, get Rhizoma Curcumae, curcuma powder and be broken into fine powder, cross 100 mesh sieves, warp
60Behind the Co irradiation, standby: b, get Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae four Chinese medicine material and be mixed in proportion after, be that 85% alcohol heating reflux extracts 2 times with accounting for four Chinese medicine gross weight 4 times of amounts, concentration respectively, return time was respectively 1 hour, then filtration, merging filtrate, it is 1.32 thick paste that decompression recycling ethanol is concentrated into relative density in the time of 60 ℃, in dry below 60 ℃, is ground into fine powder, cross 100 mesh sieves, standby; C, get Mel 1500g, heating dissolves, the 180 mesh sieve removal of impurity in the time of while hot, the fine powder that in the time of 60 ℃, adds above-mentioned Rhizoma Curcumae and Rhizoma Curcumae Longae, stir, after adding the alcohol extraction cream powder of Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, the Radix Angelicae Dahuricae four flavor Chinese medicines and concentration again and be 3% laurocapram, stirred 20 minutes, mixing gets final product.
Galactophore paste of the present invention can be used for cystic hyperplasia of breast, this sick traditional Chinese medical science qi depression to blood stasis disease that belongs to, and disease is seen lump in the breast, accompany mastalgia, mostly be distending pain, scurry pain or twinge, the costa sternales distension increases and decreases with menstrual cycle and emotion changes, dimly red tongue or ecchymosis is arranged, stringy pulse or string are puckery, and it has the effect of promoting flow of QI and blood, mass dissipating and swelling eliminating, and of the present invention have only Six-element Chinese medicine, not only cost is low for it, and good effect, preparation method is simple, is beneficial to apply.
The specific embodiment
The specific embodiment one: the unguentum in the present embodiment comprises Rhizoma Curcumae, Rhizoma Curcumae Longae, Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae Six-element Chinese medicine, and the shared parts by weight of each Chinese medicine are respectively: Rhizoma Curcumae 153-187, Rhizoma Curcumae Longae 122-150, Semen Impatientis 122-150, Radix Semiaquilegiae 91.8-112.2, Semen Momordicae 30.6-37.4, Radix Angelicae Dahuricae 45.9-56.1.Its preparation method comprises: a, get Rhizoma Curcumae, curcuma powder and be broken into fine powder, cross 100 mesh sieves, warp
60Behind the Co irradiation, standby: b, get Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae four Chinese medicine material and be mixed in proportion after, be that 85% alcohol heating reflux extracts 2 times with accounting for four Chinese medicine gross weight 4 times of amounts, concentration respectively, return time was respectively 1 hour, then filtration, merging filtrate, it is 1.32 thick paste that decompression recycling ethanol is concentrated into relative density in the time of 60 ℃, in dry below 60 ℃, is ground into fine powder, cross 100 mesh sieves, standby; C, get Mel 1500g, heating dissolves, the 180 mesh sieve removal of impurity in the time of while hot, the fine powder that in the time of 60 ℃, adds above-mentioned Rhizoma Curcumae and Rhizoma Curcumae Longae, stir, after adding the alcohol extraction cream powder of Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, the Radix Angelicae Dahuricae four flavor Chinese medicines and concentration again and be 3% laurocapram, stirred 20 minutes, mixing gets final product.
The specific embodiment two: the shared parts by weight of each Chinese medicine are respectively in the present embodiment, Rhizoma Curcumae 160, Rhizoma Curcumae Longae 125, Semen Impatientis 125, Radix Semiaquilegiae 95, Semen Momordicae 32, the Radix Angelicae Dahuricae 51.
The specific embodiment three: the shared parts by weight of each Chinese medicine are respectively in the present embodiment, Rhizoma Curcumae 170, Rhizoma Curcumae Longae 136, Semen Impatientis 136, Radix Semiaquilegiae 102, Semen Momordicae 34, the Radix Angelicae Dahuricae 51.
The specific embodiment four: the shared parts by weight of each Chinese medicine are respectively in the present embodiment, Rhizoma Curcumae 182, Rhizoma Curcumae Longae 145, Semen Impatientis 145, Radix Semiaquilegiae 108, Semen Momordicae 37, the Radix Angelicae Dahuricae 54.
The specific embodiment five: the preparation method of present embodiment is as follows: get the 1700g Rhizoma Curcumae, the 1360g curcuma powder is broken into fine powder, cross 100 mesh sieves, warp
60Behind the Co irradiation, standby: after getting 1360g Semen Impatientis, 1020g Radix Semiaquilegiae, 340g Semen Momordicae, the mixing of 510g Radix Angelicae Dahuricae four Chinese medicine material, be that 85% alcohol heating reflux extracts 2 times with accounting for four Chinese medicine gross weight 4 times of amounts, concentration respectively, return time was respectively 1 hour, then filtration, merging filtrate, it is 1.32 thick paste that decompression recycling ethanol is concentrated into relative density in the time of 60 ℃, in dry below 60 ℃, is ground into fine powder, cross 100 mesh sieves, standby; Get Mel 1500g, heating dissolves, the 180 mesh sieve removal of impurity in the time of while hot, the fine powder that in the time of 60 ℃, adds above-mentioned Rhizoma Curcumae and Rhizoma Curcumae Longae, stir, after adding the alcohol extraction cream powder of Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, the Radix Angelicae Dahuricae four flavor Chinese medicines and concentration again and be 3% laurocapram, stirred mixing 20 minutes.The gained creme is with mould molding (4 * 6.5cm, heavy 5g), and behind all cotton non-woven fabric parcel, (on 7 * 10cm), seal with plastic bag, packing is made 1000 and pasted, promptly to place tensoplast.
Character: this product is pale brown color chips shape plaster, gas perfume (or spice).
The curative effect comprehensive report:
One, case choice criteria:
1, meets the diagnostic criteria of doctor trained in Western medicine cyclomastopathy.
2, meet the dialectical standard of traditional Chinese medical science syndrome of qi stagnation and blood stasis.
3, the age is in the 18-55 women in year.
4, informed consent, the genus Informed Consent Form is tried and signed to aspiration.
Two, the diagnostic criteria of disease:
1, Western medicine diagnose standard:
(1) mastalgia;
All statistical test all adopt two-sided test, and the P value is less than or equal to 0.05 difference that will be considered to check statistical significance.
The measurement data that each time prescription on individual diagnosis is organized in different treatments will adopt mean ± standard deviation to carry out descriptive statistics.Compare with screening phase basic value, adopt front and back difference in the paired t-test comparable group.The variation of two groups of treatment front and back adopts variance analysis (ANOVA) to compare.
The enumeration data employing frequency that each time prescription on individual diagnosis is organized in different treatments is gone descriptive statistics (constituent ratio).X is adopted in the variation of two groups of treatment front and back
2Check or rank test.
| Sequence number | Age | Sex | Occupation | Before the treatment | After the treatment | Curative effect |
| 1 | 25 | The woman | The nurse | Severe | Recovery from illness | Recovery from illness |
| 2 | 25 | The woman | The workman | Severe | Slightly | Produce effects |
| 3 | 26 | The woman | The coroner | Moderate | Recovery from illness | Effectively |
| 4 | 26 | The woman | The doctor | Severe | Moderate | Effectively |
| 5 | 28 | The woman | The workman | Severe | Slightly | Produce effects |
| 6 | 28 | The woman | The peasant | Slightly | Recovery from illness | Recovery from illness |
| 7 | 28 | The woman | The civil servant | Severe | Slightly | Produce effects |
| 8 | 30 | The woman | The civil servant | Severe | Slightly | Produce effects |
| 9 | 30 | The woman | The nurse | Severe | Moderate | Effectively |
| 10 | 30 | The woman | The workman | Moderate | Slightly | Effectively |
| 11 | 33 | The woman | The coroner | Severe | Slightly | Produce effects |
| 12 | 33 | The woman | The doctor | Severe | Slightly | Produce effects |
| 13 | 33 | The woman | The workman | Slightly | Recovery from illness | Recovery from illness |
| 14 | 35 | The woman | The peasant | Slightly | Recovery from illness | Recovery from illness |
| 15 | 36 | The woman | The civil servant | Moderate | Recovery from illness | Recovery from illness |
| 16 | 36 | The woman | The workman | Severe | Recovery from illness | Recovery from illness |
| 17 | 39 | The woman | The peasant | Severe | Slightly | Produce effects |
| 18 | 39 | The woman | Accounting | Moderate | Recovery from illness | Effectively |
| 19 | 40 | The woman | The office worker | Severe | Moderate | Effectively |
| 20 | 40 | The woman | Unemployed | Severe | Slightly | Produce effects |
| 21 | 42 | The woman | Unemployed | Slightly | Recovery from illness | Recovery from illness |
| 22 | 42 | The woman | The civil servant | Severe | Slightly | Produce effects |
| 23 | 42 | The woman | The nurse | Severe | Slightly | Produce effects |
| 24 | 43 | The woman | The workman | Severe | Moderate | Effectively |
| 25 | 43 | The woman | The coroner | Moderate | Slightly | Effectively |
| 26 | 44 | The woman | The doctor | Severe | Slightly | Produce effects |
| 27 | 44 | The woman | The workman | Severe | Slightly | Produce effects |
| 28 | 44 | The woman | The peasant | Slightly | Recovery from illness | Recovery from illness |
| 29 | 46 | The woman | The civil servant | Slightly | Recovery from illness | Recovery from illness |
| 30 | 46 | The woman | The civil servant | Moderate | Recovery from illness | Recovery from illness |
Result: cure rate 33.3%, obvious effective rate 40%, effective percentage 26.7%.
(2) lump in breast;
(3) auxiliary examination: 1. the mammary gland color doppler flow imaging 2. breast molybdenum target X line take the photograph 3. pathological examination of sheet.
2, Chinese medical discrimination standard:
Syndrome of qi stagnation and blood stasis: lump in breast, mastalgia, umbrella costa sternales distension, susceptible to lose temper due to restlessness have the hypomenorrhea color dark or clot, abdominal pain during menstruation arranged.Dimly red tongue or petechia, stasis of blood class are arranged, white and thin fur, stringy pulse or string are puckery.
(1) primary symptom: lump in breast, mastalgia.
(2) inferior disease: 1. costa sternales distension; 2. susceptible to lose temper due to restlessness; 3. the few color of menstrual blood volume is dark or clot, abdominal pain during menstruation arranged.Tongue is dark red or petechia, ecchymosis, white and thin fur arranged.Pulse condition string or string are puckery.
Three, medicine ingredient: Rhizoma Curcumae, Rhizoma Curcumae Longae, Semen Impatientis, open certain herbaceous plants with big flowers, Semen Momordicae, the Radix Angelicae Dahuricae.
Four, administrated method: external.Earlier the skin affected part is cleaned and wiped away driedly, then lining paper on the plaster is thrown off, refill is aimed at the affected part stick.Once a day, each card, every subsides content of dispersion 5g.Sticked continuously 28 days.
Five, the criterion of curative effect:
1. clinical recovery: clinical symptoms, sign, lump in breast, mastalgia disappear.
2. produce effects: clinical symptoms, sign, mastalgia obviously alleviate or disappear, and the lump in breast major diameter dwindles more than 1/2.
3. effective: clinical symptoms, sign, mastalgia alleviate or disappear, and the lump in breast major diameter dwindles more than 1/3.
4. invalid: clinical symptoms, sign do not have change, and lump in breast is not seen to have and obviously dwindled or dwindle deficiency.
Six, the coincidence statistics standard is answered in the analysis of efficacy result.
The typing of data is learned the statistics specific data manager of teaching and research room with management by PLA General Hospital and is responsible for.For guaranteeing the accuracy of data, should independently carry out double typing and check and correction by two data managers.
To there being query in the case report form, the data administrator will produce FAQ table (DRQ), and send inquiry to researcher by the CRA, researcher should answer and return as early as possible, the data administrator carries out data modification, affirmation and typing according to the answer of researcher, can send DRQ once more in case of necessity.
1. intentional analysis: all are divided into groups through randomization, and use whole cases of a medicine to analyze at least.Intentional analysis carries out at curative effect and adverse events.For the case data of failing to observe whole therapeutic processes, carry over the test final result to last observed data.
2. meet the scheme data analysis: all Pass Test schemes, medication are good in 1 compliance more than 14 days, duration of test does not use the case of forbidding medication, finishing CRF regulation fill substance, and its curative effect is carried out statistical analysis.
3. statistical analysis adopts the SAS6.12 statistical analysis software to calculate.
Claims (5)
1. galactophore paste, it is characterized in that, unguentum comprises Rhizoma Curcumae, Rhizoma Curcumae Longae, Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae Six-element Chinese medicine, and the shared parts by weight of each Chinese medicine are respectively: Rhizoma Curcumae 153-187, Rhizoma Curcumae Longae 122-150, Semen Impatientis 122-150, Radix Semiaquilegiae 91.8-112.2, Semen Momordicae 30.6-37.4, Radix Angelicae Dahuricae 45.9-56.1.
2. galactophore paste according to claim 1 is characterized in that, Rhizoma Curcumae 160, Rhizoma Curcumae Longae 125, Semen Impatientis 125, Radix Semiaquilegiae 95, Semen Momordicae 32, the Radix Angelicae Dahuricae 48.
3. galactophore paste according to claim 1 is characterized in that, Rhizoma Curcumae 170, Rhizoma Curcumae Longae 136, Semen Impatientis 136, Radix Semiaquilegiae 102, Semen Momordicae 34, the Radix Angelicae Dahuricae 51.
4. galactophore paste according to claim 1 is characterized in that, Rhizoma Curcumae 182, Rhizoma Curcumae Longae 145, Semen Impatientis 145, Radix Semiaquilegiae 108, Semen Momordicae 37, the Radix Angelicae Dahuricae 54.
5. the preparation method of a galactophore paste is characterized in that, a, gets Rhizoma Curcumae, curcuma powder and is broken into fine powder, crosses 100 mesh sieves, warp
60Behind the Co irradiation, standby: b, get Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae four Chinese medicine material and be mixed in proportion after, be that 85% alcohol heating reflux extracts 2 times with accounting for four Chinese medicine gross weight 4 times of amounts, concentration respectively, return time was respectively 1 hour, then filtration, merging filtrate, it is 1.32 thick paste that decompression recycling ethanol is concentrated into relative density in the time of 60 ℃, in dry below 60 ℃, is ground into fine powder, cross 100 mesh sieves, standby; C, get Mel 1500g, heating dissolves, the 180 mesh sieve removal of impurity in the time of while hot, the fine powder that in the time of 60 ℃, adds above-mentioned Rhizoma Curcumae and Rhizoma Curcumae Longae, stir, after adding the alcohol extraction cream powder of Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, the Radix Angelicae Dahuricae four flavor Chinese medicines and concentration again and be 3% laurocapram, stirred 20 minutes, mixing gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101455076A CN101147798A (en) | 2007-08-28 | 2007-08-28 | Galactophore paste and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101455076A CN101147798A (en) | 2007-08-28 | 2007-08-28 | Galactophore paste and its preparing process |
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| CN101147798A true CN101147798A (en) | 2008-03-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101455076A Pending CN101147798A (en) | 2007-08-28 | 2007-08-28 | Galactophore paste and its preparing process |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230555A (en) * | 2013-04-23 | 2013-08-07 | 山西丰源药业有限公司 | External medicine for treating hyperplasia of mammary glands and preparation method thereof |
| CN103394043A (en) * | 2013-08-15 | 2013-11-20 | 黑龙江鹤翔制药有限责任公司 | Application of stasis-removing paste for nodules of breast for treatment of primary dysmenorrheal and ovarian cyst |
| CN107823572A (en) * | 2017-12-07 | 2018-03-23 | 珠海横琴亘德生物科技有限公司 | A kind of Chinese recipe for female breast nursing |
| CN109125397A (en) * | 2018-11-14 | 2019-01-04 | 杨中泽 | A kind of Chinese materia medica preparation for treating breast cancer |
| CN112791167A (en) * | 2021-01-12 | 2021-05-14 | 杭州青蜓遵序堂健康管理有限公司 | Preparation process of pain-relieving and stasis-removing hydrogel patch |
-
2007
- 2007-08-28 CN CNA2007101455076A patent/CN101147798A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230555A (en) * | 2013-04-23 | 2013-08-07 | 山西丰源药业有限公司 | External medicine for treating hyperplasia of mammary glands and preparation method thereof |
| CN103230555B (en) * | 2013-04-23 | 2015-02-25 | 山西丰源药业有限公司 | External medicine for treating hyperplasia of mammary glands and preparation method thereof |
| CN103394043A (en) * | 2013-08-15 | 2013-11-20 | 黑龙江鹤翔制药有限责任公司 | Application of stasis-removing paste for nodules of breast for treatment of primary dysmenorrheal and ovarian cyst |
| CN107823572A (en) * | 2017-12-07 | 2018-03-23 | 珠海横琴亘德生物科技有限公司 | A kind of Chinese recipe for female breast nursing |
| CN109125397A (en) * | 2018-11-14 | 2019-01-04 | 杨中泽 | A kind of Chinese materia medica preparation for treating breast cancer |
| CN112791167A (en) * | 2021-01-12 | 2021-05-14 | 杭州青蜓遵序堂健康管理有限公司 | Preparation process of pain-relieving and stasis-removing hydrogel patch |
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Application publication date: 20080326 |