CN1251755C - Ointment for dispersing breast nodules and preparation method thereof - Google Patents
Ointment for dispersing breast nodules and preparation method thereof Download PDFInfo
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- CN1251755C CN1251755C CN 200410043648 CN200410043648A CN1251755C CN 1251755 C CN1251755 C CN 1251755C CN 200410043648 CN200410043648 CN 200410043648 CN 200410043648 A CN200410043648 A CN 200410043648A CN 1251755 C CN1251755 C CN 1251755C
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Abstract
The present invention relates to an ointment for dispersing breast nodules and a preparing method thereof, which relates to an external applying ointment used for treating breast diseases and a preparing method thereof. The existing traditional Chinese medicine for treating the breast diseases has the defects of high cost and complicated working procedures. In the stasis dispersing breast nodule adhering ointment, the weight part of each traditional Chinese medicine is 153 to 187 parts of zedoary, 122 to 150 parts of turmeric, 122 to 150 parts of garden balsam seeds, 91.8 to 112.2 parts of muskrootlike semiaquilegia roots, 30.6 to 37.4 parts of semen momordicae, and 45.9 to 56.1 parts of dahurian angelica roots. The preparing method comprises the steps of pulverizing the zedoary and the turmeric into fine powder, preparing the alcohol extracting paste of the garden balsam seeds, the muskrootlike semiaquilegia roots, the semen momordicae and the dahurian angelica roots, heating honey, agitating the mixture, etc. The stasis dispersing breast nodule adhering ointment of the present invention has the functions of promoting flow of qi and blood circulation, removing stasis and reducing edema. The present invention has the advantages of low cost, good treating effect and simple preparing method, and is helpful for popularization and application.
Description
Technical field:
The present invention relates to mastotic externally used paste of a kind of treatment and preparation method thereof.
Background technology:
There is the drawback that Chinese medicine ingredients is many, cost is high, curative effect is bad in the mastotic Chinese medicine of existing treatment, and there is the drawback of complex procedures in prior preparation method.
Summary of the invention:
The object of the present invention is to provide a kind of good effect, the simple eliminating stagnation nodules of the breast of preparation section plaster and preparation method thereof, the unguentum of eliminating stagnation nodules of the breast plaster is to be prepared from by Rhizoma Curcumae, Rhizoma Curcumae Longae, Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae Six-element Chinese medicine, and the shared parts by weight of each Chinese medicine are respectively: Rhizoma Curcumae 153～187, Rhizoma Curcumae Longae 122～150, Semen Impatientis 122～150, Radix Semiaquilegiae 91.8～112.2, Semen Momordicae 30.6～37.4, the Radix Angelicae Dahuricae 45.9～56.1.Its preparation method comprises: a. gets 153～187 parts of Rhizoma Curcumae by weight, Rhizoma Curcumae Longae is ground into fine powder for 122～150 parts, crosses 100 mesh sieves, warp
60Behind the Co irradiation, standby; B. get 122～150 parts of Semen Impatientis, 91.8～112.2 parts of Radix Semiaquilegiaes, 30.6～37.4 parts of Semen Momordicaes, 45.9～56.1 parts of the Radixs Angelicae Dahuricae, after the four Chinese medicine material is mixed in proportion, be that 85% alcohol heating reflux extracts 2 times with accounting for four Chinese medicine gross weight 4 times of amounts, concentration respectively, return time was respectively 1 hour, then filtration, merging filtrate, it is 1.32 thick paste that decompression recycling ethanol is concentrated into relative density in the time of 60 ℃, in dry below 60 ℃, is ground into fine powder, cross 100 mesh sieves, standby; Get Mel 1500g, heating dissolves, cross the 180 mesh sieve removal of impurity while hot, the fine powder that in the time of 60 ℃, adds above-mentioned Rhizoma Curcumae and Rhizoma Curcumae Longae, stir, after adding the alcohol extraction cream powder of Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, the Radix Angelicae Dahuricae four flavor Chinese medicines and concentration again and be 3% laurocapram, stirred 20 minutes, mixing gets final product.
Eliminating stagnation nodules of the breast plaster of the present invention can be used for cystic hyperplasia of breast, this sick genus traditional Chinese medical science qi depression to blood stasis disease, and disease is seen lump in the breast, accompany mastalgia, mostly be distending pain, scurry pain or twinge, the costa sternales distension increases and decreases with menstrual cycle and emotion changes, dimly red tongue or ecchymosis is arranged, stringy pulse or string are puckery, and it has the effect of promoting flow of QI and blood, mass dissipating and swelling eliminating, and of the present invention have only Six-element Chinese medicine, not only cost is low for it, and good effect, preparation method is simple, is beneficial to apply.
The specific embodiment:
The specific embodiment one: the unguentum in the present embodiment comprises Rhizoma Curcumae, Rhizoma Curcumae Longae, Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae Six-element Chinese medicine, and the shared parts by weight of each Chinese medicine are respectively: Rhizoma Curcumae 153～187, Rhizoma Curcumae Longae 122～150, Semen Impatientis 122～150, Radix Semiaquilegiae 91.8～112.2, Semen Momordicae 30.6～37.4, the Radix Angelicae Dahuricae 45.9～56.1; Its preparation method is: a gets Rhizoma Curcumae, curcuma powder is broken into fine powder, crosses 100 mesh sieves, warp
60Behind the Co irradiation, standby; B. after getting Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae four Chinese medicine material and being mixed in proportion, be 85% alcohol heating reflux extraction 2 times with accounting for four Chinese medicine gross weight 4 times of amounts, concentration respectively, return time was respectively 1 hour, filter then, it is 132 thick paste that merging filtrate, decompression recycling ethanol are concentrated into relative density in the time of 60 ℃, in dry below 60 ℃, be ground into fine powder, cross 100 mesh sieves, standby; Get Mel 1500g, heating dissolves, cross the 180 mesh sieve removal of impurity while hot, the fine powder that when 60, adds above-mentioned Rhizoma Curcumae and Rhizoma Curcumae Longae, stir, after adding the alcohol extraction cream powder of Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, the Radix Angelicae Dahuricae four flavor Chinese medicines and concentration again and be 3% laurocapram, stirred 20 minutes, mixing gets final product.
The specific embodiment two: the shared parts by weight of each Chinese medicine are respectively in the present embodiment, Rhizoma Curcumae 160, Rhizoma Curcumae Longae 125, Semen Impatientis 125, Radix Semiaquilegiae 95, Semen Momordicae 32, the Radix Angelicae Dahuricae 48.
The specific embodiment three: the shared parts by weight of each Chinese medicine are respectively in the present embodiment, Rhizoma Curcumae 170, Rhizoma Curcumae Longae 136, Semen Impatientis 136, Radix Semiaquilegiae 102, Semen Momordicae 34, the Radix Angelicae Dahuricae 51.
The specific embodiment four: the shared parts by weight of each Chinese medicine are respectively in the present embodiment, Rhizoma Curcumae 182, Rhizoma Curcumae Longae 145, Semen Impatientis 145, Radix Semiaquilegiae 108, Semen Momordicae 37, the Radix Angelicae Dahuricae 54.
The specific embodiment five: the preparation method of present embodiment is as follows: get 1700g Rhizoma Curcumae, 1360g Rhizoma Curcumae Longae, be ground into fine powder, cross 100 mesh sieves, warp
60Behind the Co irradiation, standby; After getting 1360g Semen Impatientis, 1020g Radix Semiaquilegiae, 340g Semen Momordicae, the mixing of 510g Radix Angelicae Dahuricae four Chinese medicine material, be 85% alcohol heating reflux extraction 2 times with accounting for four Chinese medicine gross weight 4 times of amounts, concentration respectively, return time was respectively 1 hour, filter, it is 1.32 thick paste that merging filtrate, decompression recycling ethanol are concentrated into relative density in the time of 60 ℃, in dry below 60 ℃, be ground into fine powder, cross 100 mesh sieves, standby; Get Mel 1500g, heating dissolves, cross the 180 mesh sieve removal of impurity while hot, the fine powder that when 60, adds above-mentioned Rhizoma Curcumae and Rhizoma Curcumae Longae, stir, after adding the alcohol extraction cream powder of Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, the Radix Angelicae Dahuricae four flavor Chinese medicines and concentration again and be 3% laurocapram, stirred mixing 20 minutes.The gained creme is with mould molding (4 * 6.5cm, heavy 5g), and behind all cotton non-woven fabric parcel, (on 7 * 10cm), seal with plastic bag, packing is made 1000 and pasted, promptly to place tensoplast.
Character: this product is pale brown color chips shape plaster, gas perfume (or spice).
The curative effect comprehensive report:
One. the case choice criteria:
1. meet the diagnostic criteria of doctor trained in Western medicine cyclomastopathy.
2. meet the dialectical standard of traditional Chinese medical science syndrome of qi stagnation and blood stasis.
3. the age was 18～55 years old women.
4. informed consent volunteers to be tried and sign the genus Informed Consent Form.
Two, the diagnostic criteria of disease:
1. Western medicine diagnose standard:
(1) mastalgia;
(2) lump in breast;
(3) auxiliary examination: 1. the mammary gland color doppler flow imaging 2. breast molybdenum target X line take the photograph 3. pathological examination of sheet.
2. Chinese medical discrimination standard:
Syndrome of qi stagnation and blood stasis: lump in breast, mastalgia, companion's costa sternales distension, susceptible to lose temper due to restlessness, the few color of menstrual blood volume is dark or clot, abdominal pain during menstruation arranged.Dimly red tongue or petechia, ecchymosis are arranged, white and thin fur, stringy pulse or string are puckery.
(1) primary symptom: lump in breast, mastalgia.
(2) inferior disease: 1. costa sternales distension; 2. susceptible to lose temper due to restlessness; 3. the few color of menstrual blood volume is dark or clot, abdominal pain during menstruation arranged.Tongue is dark red or petechia, ecchymosis, white and thin fur arranged.Pulse condition string or string are puckery.
Three. medicine ingredient: Rhizoma Curcumae, Rhizoma Curcumae Longae, Semen Impatientis, open certain herbaceous plants with big flowers, Semen Momordicae, the Radix Angelicae Dahuricae.
Four. administrated method: external.Earlier the skin affected part is cleaned and wiped away driedly, then lining paper on the plaster is thrown off, medicated core is aimed at the affected part stick.Once a day, each one pastes every subsides content of dispersion 5g.Sticked continuously 28 days.
Five. the criterion of curative effect:
1. clinical recovery: clinical symptoms, sign, lump in breast, mastalgia disappear.
2. produce effects: clinical symptoms, sign, mastalgia obviously alleviate or disappear, and the lump in breast major diameter dwindles more than 1/2.
3. effective: clinical symptoms, sign, mastalgia alleviate or disappear, and the lump in breast major diameter dwindles more than 1/3.
4. invalid: clinical symptoms, sign do not have change, and lump in breast is not seen to have and obviously dwindled or dwindle deficiency.
Six. the analysis of efficacy result, answer the coincidence statistics standard:
The typing of data is responsible for by the specific data manager of PLA General Hospital medical statistics teaching and research room with management.For guaranteeing the accuracy of data, should independently carry out double typing and check and correction by two data managers.
To the query that exists in the case report form, the data administrator will produce FAQ table (DRQ), and send inquiry to researcher by the CRA, researcher should answer and return as early as possible, the data administrator carries out data modification, affirmation and typing according to the answer of researcher, can send DRQ once more in case of necessity.
1. intentional analysis: all are divided into groups through randomization, and use whole cases of a medicine to analyze at least.Intentional analysis carries out at curative effect and adverse events.For the case data of failing to observe whole therapeutic processes, carry over the test final result to last observed data.
2. meet the scheme data analysis: all Pass Test schemes, medication more than 14 days, good, the duration of test of compliance do not use the case of forbidding medication, finishing CRF regulation fill substance, and its curative effect is carried out statistical analysis.
3. statistical analysis adopts SAS 6.12 statistical analysis softwares to calculate.
All statistical test all adopt two-sided test, and the P value is less than or equal to 0.05 difference that will be considered to be checked statistical significance.
The measurement data that each time prescription on individual diagnosis is organized in different treatments will adopt mean ± standard deviation to carry out descriptive statistics.Compare with screening phase basic value, adopt front and back difference in the paired t-test comparable group.The variation of two groups of treatment front and back adopts variance analysis (ANOVA) to compare.
The enumeration data that each time prescription on individual diagnosis is organized in different treatments adopts frequency (constituent ratio) to carry out descriptive statistics.X is adopted in the variation of two groups of treatment front and back
2Check or rank test.
| Sequence number | Age | Sex | Occupation | Before the treatment | After the treatment | Curative effect |
| 1 | 25 | The woman | The nurse | Severe | Recovery from illness | Recovery from illness |
| 2 | 25 | The woman | The workman | Severe | Slightly | Produce effects |
| 3 | 26 | The woman | The coroner | Moderate | Recovery from illness | Effectively |
| 4 | 26 | The woman | The doctor | Severe | Moderate | Effectively |
| 5 | 28 | The woman | The workman | Severe | Slightly | Produce effects |
| 6 | 28 | The woman | The peasant | Slightly | Recovery from illness | Recovery from illness |
| 7 | 28 | The woman | The civil servant | Severe | Slightly | Produce effects |
| 8 | 30 | The woman | The civil servant | Severe | Slightly | Produce effects |
| 9 | 30 | The woman | The nurse | Severe | Moderate | Effectively |
| 10 | 30 | The woman | The workman | Moderate | Slightly | Effectively |
| 11 | 33 | The woman | The coroner | Severe | Slightly | Produce effects |
| 12 | 33 | The woman | The doctor | Severe | Slightly | Produce effects |
| 13 | 33 | The woman | The workman | Slightly | Recovery from illness | Recovery from illness |
| 14 | 35 | The woman | The peasant | Slightly | Recovery from illness | Recovery from illness |
| 15 | 36 | The woman | The civil servant | Moderate | Recovery from illness | Recovery from illness |
| 16 | 36 | The woman | The workman | Severe | Recovery from illness | Recovery from illness |
| 17 | 39 | The woman | The peasant | Severe | Slightly | Produce effects |
| 18 | 39 | The woman | Accounting | Moderate | Recovery from illness | Effectively |
| 19 | 40 | The woman | The office worker | Severe | Moderate | Effectively |
| 20 | 40 | The woman | Unemployed | Severe | Slightly | Produce effects |
| 21 | 42 | The woman | Unemployed | Slightly | Recovery from illness | Recovery from illness |
| 22 | 42 | The woman | The civil servant | Severe | Slightly | Produce effects |
| 23 | 42 | The woman | The nurse | Severe | Slightly | Produce effects |
| 24 | 43 | The woman | The workman | Severe | Moderate | Effectively |
| 25 | 43 | The woman | The coroner | Moderate | Slightly | Effectively |
| 26 | 44 | The woman | The doctor | Severe | Slightly | Produce effects |
| 27 | 44 | The woman | The workman | Severe | Slightly | Produce effects |
| 28 | 44 | The woman | The peasant | Slightly | Recovery from illness | Recovery from illness |
| 29 | 46 | The woman | The civil servant | Slightly | Recovery from illness | Recovery from illness |
| 30 | 46 | The woman | The civil servant | Moderate | Recovery from illness | Recovery from illness |
Result: cure rate 33.3%, obvious effective rate 40%, effective percentage 26.7%.
Claims (5)
1, a kind of eliminating stagnation nodules of the breast plaster, it is characterized in that unguentum is to be prepared from by Rhizoma Curcumae, Rhizoma Curcumae Longae, Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, Radix Angelicae Dahuricae Six-element Chinese medicine, the shared parts by weight of each Chinese medicine are respectively: Rhizoma Curcumae 153～187, Rhizoma Curcumae Longae 122～150, Semen Impatientis 122～150, Radix Semiaquilegiae 91.8～112.2, Semen Momordicae 30.6～37.4, the Radix Angelicae Dahuricae 45.9～56.1.
2, eliminating stagnation nodules of the breast plaster according to claim 1 is characterized in that the shared parts by weight of each Chinese medicine are respectively, Rhizoma Curcumae 160, Rhizoma Curcumae Longae 125, Semen Impatientis 125, Radix Semiaquilegiae 95, Semen Momordicae 32, the Radix Angelicae Dahuricae 48.
3, eliminating stagnation nodules of the breast plaster according to claim 1 is characterized in that the shared parts by weight of each Chinese medicine are respectively, Rhizoma Curcumae 170, Rhizoma Curcumae Longae 136, Semen Impatientis 136, Radix Semiaquilegiae 102, Semen Momordicae 34, the Radix Angelicae Dahuricae 51.
4, eliminating stagnation nodules of the breast plaster according to claim 1 is characterized in that the shared parts by weight of each Chinese medicine are respectively, Rhizoma Curcumae 182, Rhizoma Curcumae Longae 145, Semen Impatientis 145, Radix Semiaquilegiae 108, Semen Momordicae 37, the Radix Angelicae Dahuricae 54.
5, a kind of preparation method of eliminating stagnation nodules of the breast plaster is characterized in that a. gets 153～187 parts of Rhizoma Curcumae by weight, Rhizoma Curcumae Longae is ground into fine powder for 122～150 parts, crosses 100 mesh sieves, warp
60Behind the Co irradiation, standby; B. get 122～150 parts of Semen Impatientis, 91.8～112.2 parts of Radix Semiaquilegiaes, 30.6～37.4 parts of Semen Momordicaes, 45.9～56.1 parts of the Radixs Angelicae Dahuricae, after the four Chinese medicine material is mixed in proportion, be that 85% alcohol heating reflux extracts 2 times with accounting for four Chinese medicine gross weight 4 times of amounts, concentration respectively, return time was respectively 1 hour, then filtration, merging filtrate, it is 1.32 thick paste that decompression recycling ethanol is concentrated into relative density in the time of 60 ℃, in dry below 60 ℃, is ground into fine powder, cross 100 mesh sieves, standby; Get Mel 1500g, heating dissolves, cross the 180 mesh sieve removal of impurity while hot, the fine powder that in the time of 60 ℃, adds above-mentioned Rhizoma Curcumae and Rhizoma Curcumae Longae, stir, after adding the alcohol extraction cream powder of Semen Impatientis, Radix Semiaquilegiae, Semen Momordicae, the Radix Angelicae Dahuricae four flavor Chinese medicines and concentration again and be 3% laurocapram, stirred 20 minutes, mixing gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410043648 CN1251755C (en) | 2004-06-23 | 2004-06-23 | Ointment for dispersing breast nodules and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410043648 CN1251755C (en) | 2004-06-23 | 2004-06-23 | Ointment for dispersing breast nodules and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1593599A CN1593599A (en) | 2005-03-16 |
| CN1251755C true CN1251755C (en) | 2006-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410043648 Active - Reinstated CN1251755C (en) | 2004-06-23 | 2004-06-23 | Ointment for dispersing breast nodules and preparation method thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394043A (en) * | 2013-08-15 | 2013-11-20 | 黑龙江鹤翔制药有限责任公司 | Application of stasis-removing paste for nodules of breast for treatment of primary dysmenorrheal and ovarian cyst |
| CN106361960A (en) * | 2016-09-30 | 2017-02-01 | 上海御贴医药科技有限公司 | Traditional Chinese medicine composition capable of treating breast paste and preparation method thereof |
| CN109260426B (en) * | 2018-12-11 | 2021-08-17 | 周金 | External traditional Chinese medicine for eliminating mass, eliminating stagnation and relieving pain and preparation method and application thereof |
| CN112791167A (en) * | 2021-01-12 | 2021-05-14 | 杭州青蜓遵序堂健康管理有限公司 | Preparation process of pain-relieving and stasis-removing hydrogel patch |
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| CN1593599A (en) | 2005-03-16 |
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Owner name: HEILONGJIANG HEXIANG PHARMACEUTICAL CO. Free format text: FORMER OWNER: QIQIHAR HEXIANG PHARMACEUTICAL CO., LTD. Effective date: 20061020 |
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Effective date of registration: 20061020 Address after: 161005 Qigihar city of Heilongjiang Province, the southern suburbs of Longsha District Road No. 3 Patentee after: Heilongjiang Hexiang Pharmaceutical Co., Ltd. Address before: 161005 Qigihar city in Heilongjiang Province town in Longsha District Patriotic Village Patentee before: Qiqihar Hexiang Pharmaceutical Co., Ltd. |
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Denomination of invention: Ointment for dispersing breast nodules and preparation method thereof Effective date of registration: 20130820 Granted publication date: 20060419 Pledgee: Heilongjiang Chen energy Company limited by guarantee Pledgor: Heilongjiang Hexiang Pharmaceutical Co., Ltd. Registration number: 2013230000014 |
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Date of cancellation: 20140313 Granted publication date: 20060419 Pledgee: Heilongjiang Chen energy Company limited by guarantee Pledgor: Heilongjiang Hexiang Pharmaceutical Co., Ltd. Registration number: 2013230000014 |
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Former decision: cessation of patent right due to non-payment of the annual fee Former decision publication date: 20150812 |