CN1257735C - Medicine for treating heart function insufficieny and preparing method thereof - Google Patents
Medicine for treating heart function insufficieny and preparing method thereof Download PDFInfo
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- CN1257735C CN1257735C CN 200310101848 CN200310101848A CN1257735C CN 1257735 C CN1257735 C CN 1257735C CN 200310101848 CN200310101848 CN 200310101848 CN 200310101848 A CN200310101848 A CN 200310101848A CN 1257735 C CN1257735 C CN 1257735C
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Abstract
The present invention relates to medicine for treating cardiac insufficiency and a preparation method thereof. Eight kinds of traditional Chinese medicine (radix, lilyturf roots, red sage roots, ginseng, scrophularia roots, caulis lonicerae, arborvitae seeds and jujube seeds) are made into film coat traditional Chinese medicine according to a recipe and a preparation method in a specification. The present invention has the advantages of scientific preparation method, high active ingredient, preeminent therapeutic effect and high cure rate (which reaches 96%). Products of the present invention are used for treating the cardiac insufficiency and diseases (such as palpitation, short breath, intensified short breath by movement, light headedness, drop beat, etc.) caused by palpitation of lower than three stage.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, relate to a kind of medicine for the treatment of cardiac insufficiency and preparation method thereof.
Background technology
The patient of cardiac insufficiency, mainly show as cardiopalmus, breathe hard, movingly then aggravate, have a dizzy spell, weak thirsty, tongue is red partially, deep-thready pulse weak or knot generation etc. symptom.Cardiac insufficiency is that a kind of cause of disease is many, and the commonly encountered diseases that type is many is most with supplementing QI and nourishing YIN, the medicine of blood circulation promoting and blood stasis dispelling, but its effect is undesirable, and its reason is can not medicine typing, does not therefore still have specific drug at present.
Summary of the invention
The objective of the invention is to solve the problem of above-mentioned existence, and provide a kind of the multiple heart sheet of king) and preparation method thereof can be according to the medicine of the treatment cardiac insufficiency of the characteristics of cardiac insufficiency disease morbidity and Chinese medicine medicine typing (trade name:.
The present invention seeks to realize by following technical proposal:
A kind of medicine for the treatment of cardiac insufficiency is the thin membrane coated tablet Chinese medicine of being made by the following weight proportion raw material:
Radix Asparagi 260-280 part 260-280 Radix Ophiopogonis part Radix Salviae Miltiorrhizae 170-190 part
Radix Ginseng 170-190 part Radix Scrophulariae 170-190 part Caulis Lonicerae 170-190 part
Semen Platycladi 170-190 part Semen Ziziphi Spinosae 170-190 part;
Preparation method is characterized in that it is undertaken by the prescription and the following step of medicine material:
(a) Radix Ginseng is pulverized standby;
(b) Radix Salviae Miltiorrhizae is added 10 times 95% ethanol of raw material weight, the heating and refluxing extraction secondary, each time is 2,1 hours, merge extractive liquid, filters, and is concentrated into the thick paste of relative density 1.30-1.35, and 58-62 ℃, drying under reduced pressure, 58-62 ℃, pulverize, standby;
(c) medicinal residues with (b) item mix with Radix Ginseng, Radix Scrophulariae, Radix Asparagi, Radix Ophiopogonis, Caulis Lonicerae, Semen Ziziphi Spinosae and Semen Platycladi, and 10 times the decocting that adds raw material weight boils 3 times, is followed successively by 3,2,1 hours, collecting decoction filters, and filtrate decompression is concentrated into the clear paste of relative density 1.10-1.15,23-27 ℃, add ethanol, stir, left standstill 24 hours, and 3-5 ℃, filtered, reclaim ethanol and be concentrated into the thick paste of relative density 1.30-1.35,58-62 ℃, drying under reduced pressure (60-80 ℃), pulverize, standby;
(d) with (a) (b) (c) three fine powder mixings, add 4-6% starch, mixing is made granule with 83% ethanol, drying;
(e) granule with (d) item adds the 0.4-0.6% magnesium stearate, mixing, and tabletting, the bag film-coat promptly obtains product of the present invention.
Composition of raw materials of the present invention is according to cardiac insufficiency characteristics of incidence and tcm syndrome differentiation and typing, and in conjunction with clinical practice, with nourishing YIN and clearing away fire, tranquilizing by nourishing the heart is the rule of treatment, through updating and the pure Chinese medicine medicine developed for many years.Test respectively, analyze, differentiate through pharmacodynamic index, obtain the best of breed prescription at last, the index of drug effect is mainly cardiac determination, Electrocardioscopy.
Raw material Radix Salviae Miltiorrhizae of the present invention contains fat-soluble and water solublity two compositions, and liposoluble constituent dissolves in the ethanol, is slightly soluble in the water.So adopt ethanol reflux extraction to extract fat soluble ingredient of red sage root.Radix Salviae Miltiorrhizae contains water soluble ingredient in addition, mainly contains liposoluble ingredient, during specific examples of such components is soluble in water, is dissolved in the ethanol again; The main effective ingredient of Radix Ginseng is the ginsenoside; The main effective ingredient of Radix Scrophulariae is the Radix Scrophulariae element, rhinanthin, Harpagide, iridoids glycosides and flavonoid glycosides such as aucubin; Radix Asparagi mainly contains the amino acids composition, and being mainly agedoite is asparagine, and other contains steroidal saponin; Mainly contain steroidal saponin Radix Ophiopogonis; Caulis Lonicerae claims Flos Lonicerae again, and main effective ingredient is a triterpene saponin, and other contains flavonoid glycoside; The Semen Platycladi main component is a fatty oil, and contains a small amount of volatile oil and saponin.These compositions are water soluble, dissolve in the ethanol again, so adopt decoction alcohol precipitation method to extract.
The present invention compared with the prior art, have following advantage: medicine of the present invention is a principle with nourishing YIN and clearing away fire, tranquilizing by nourishing the heart, cardiopalmus below three grades of, cardiac function low to cardiac function due to a variety of causes, breathe hard, movingly then aggravate, have a dizzy spell, weak thirsty, tongue is red partially, a little less than the deep-thready pulse or knot generation have good therapeutic effect, cure rate 96% has preparation method science, advantage and effect that effective ingredient is high.
Specific implementation method
Enumerate 3 embodiment below, the present invention is further specified.But the present invention is not only limited to these embodiment.
Embodiment 1
Get 36g Radix Ginseng (account for Radix Ginseng total amount 1/5) and be ground into fine powder, standby; 10 times 95% ethanol that the 180g Radix Salviae Miltiorrhizae is added raw material weight, carry out the heating and refluxing extraction secondary according to a conventional method, each time is 2,1 hours, merge extractive liquid,, filter, reclaim ethanol and be concentrated into the thick paste of relative density 1.30-1.35 (60 ℃), drying under reduced pressure (60 ℃), be ground into fine powder, standby; Radix Salviae Miltiorrhizae decoction dregs and 144g Radix Ginseng, the 180g Radix Scrophulariae, the 270g Radix Asparagi, 270g Radix Ophiopogonis, 180g Caulis Lonicerae, 180g Semen Ziziphi Spinosae and 180g Semen Platycladi mix, 10 times the decocting that adds raw material weight boils 3 times, is followed successively by collecting decoction 3,2,1 hours, filter, filtrate decompression is concentrated into the clear paste of relative density 1.10-1.15 (25 ℃), adds ethanol and makes determining alcohol reach 60%, stirs, leave standstill 24 hours (4 ℃), filter, reclaim ethanol and be concentrated into the thick paste of relative density 1.30-1.35 (60 ℃), drying under reduced pressure (60-80 ℃), be ground into fine powder, standby; Merge with above-mentioned 2 kinds of medicated powder, add 5% starch, mixing, 83% ethanol is made granule, and oven dry adds 0.5% magnesium stearate, and mixing is crossed 12 mesh sieves, is pressed into 1000, and the bag film-coat promptly obtains product of the present invention.
Embodiment 2
With Radix Asparagi and Radix Ophiopogonis each 260g, Radix Salviae Miltiorrhizae, Radix Ginseng, Radix Scrophulariae, Caulis Lonicerae, Semen Platycladi, each 170g of Semen Ziziphi Spinosae replace the raw material among the embodiment 1, preparation method is with embodiment 1.
Embodiment 3
With Radix Asparagi and Radix Ophiopogonis each 280g, Radix Salviae Miltiorrhizae, Radix Ginseng, Radix Scrophulariae, Caulis Lonicerae, Semen Platycladi, each 190g of Semen Ziziphi Spinosae replace the raw material among the embodiment 1, preparation method is with embodiment 1.
Medicine of the present invention carries out clinical observation, and its result is as follows:
1, physical data
Case 168 examples, male 99 examples, women 79 examples, age 20-30 year 26 examples, 31-41 year 40 examples, 41-50 year 49 examples, 51-60 year 33 examples, 20 examples more than 60 years old.
One, diagnostic criteria
(1) tcm diagnosis standard
Cardiopalmus, breathe hard, moving then aggravate, have a dizzy spell, weak thirsty, tongue is red partially, deep-thready pulse weak or knot generation.
(2) differential diagnosis in tcm
Motive yin deficiency syndrome.
Two, test case standard and foundation
The tcm diagnosis standard that meets cardiac insufficiency
(1) cardiopalmus, breathe hard, moving then aggravate, have a dizzy spell, weak thirsty.
(2) tongue is red partially, deep-thready pulse weak or tie generation.
Three, effectiveness is observed
1, observation index
(1) leading indicator: cardiac determination, Electrocardioscopy.
(2) less important index: clinical symptoms, tongue arteries and veins.
2, curative effect determinate standard:
(1) clinical cure: cardiac function is corrected the level to I, symptom, and sign disappears substantially, and it is normal that every inspection recovers substantially.
(2) produce effects: the cardiac function progress is more than 2 grades, and do not reach I level cardiac function, and symptom, sign and every inspection obviously improve.
(3) effective: more than the cardiac function progress I level, and do not reach I level cardiac function, symptom, sign and every inspection make moderate progress.
(4) invalid: cardiac function does not have significant change, or increases the weight of, or dead.
Product of the present invention is used for the treatment of cardiac insufficiency, after one's own heart cardiopalmus below three grades of hypofunction, cardiac function, breathe hard, moving then aggravation, dizzy margins of eyelids, tie disease such as generation.
Claims (2)
1, a kind of Chinese medicine Film coated tablets for the treatment of cardiac insufficiency is characterized in that, its effective ingredient is to be made by the following weight Chinese medicinal raw materials:
Radix Asparagi 260-280 part 260-280 Radix Ophiopogonis part Radix Salviae Miltiorrhizae 170-190 part
Radix Ginseng 170-190 part Radix Scrophulariae 170-190 part Caulis Lonicerae 170-190 part
Semen Platycladi 170-190 part Semen Ziziphi Spinosae 170-190 part.
2, prepare the method for the described Film coated tablets of claim 1, it is characterized in that, undertaken by following step:
A, that 1/5th of Radix Ginseng total amount is ground into fine powder is standby;
B, Radix Salviae Miltiorrhizae is added 10 times 95% ethanol of raw material weight, the heating and refluxing extraction secondary, each time is 2,1 hours, merge extractive liquid, filters, and reclaims ethanol and is concentrated into the thick paste of 58-62 ℃ of following relative density 1.30-1.35, at 58-62 ℃ of following drying under reduced pressure, be ground into fine powder, standby;
C, medicinal residues and Radix Scrophulariae with the b item, Radix Asparagi, Radix Ophiopogonis, Caulis Lonicerae, Semen Ziziphi Spinosae, Semen Platycladi and surplus Radix Ginseng mix, 10 times the decocting that adds raw material weight boils 3 times, be followed successively by 3,2,1 hours, collecting decoction, filter, filtrate decompression is concentrated into the clear paste of 23-27 ℃ of following relative density 1.10-1.15, adds ethanol, makes alcoholic degree reach 60%, stir, 3-5 ℃ left standstill 24 hours, filtered, and reclaimed ethanol and concentrated, thick paste at 58-62 ℃ of following relative density 1.30-1.35, at 60-80 ℃ of following drying under reduced pressure, be ground into fine powder, standby;
D, with a, b, three fine powder mixings of c, add 4-6% starch, mixing is made granule with 83% ethanol, dries;
E, the granule of d item is added the 0.4-0.6% magnesium stearate, mixing, tabletting, the bag film-coat, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310101848 CN1257735C (en) | 2003-10-21 | 2003-10-21 | Medicine for treating heart function insufficieny and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310101848 CN1257735C (en) | 2003-10-21 | 2003-10-21 | Medicine for treating heart function insufficieny and preparing method thereof |
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| Publication Number | Publication Date |
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| CN1528405A CN1528405A (en) | 2004-09-15 |
| CN1257735C true CN1257735C (en) | 2006-05-31 |
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| CN 200310101848 Expired - Fee Related CN1257735C (en) | 2003-10-21 | 2003-10-21 | Medicine for treating heart function insufficieny and preparing method thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105456607A (en) * | 2015-12-31 | 2016-04-06 | 张希侠 | Preparation method of prenatal preventive medicine for cardiac insufficiency |
| CN111658726A (en) * | 2020-06-22 | 2020-09-15 | 新疆医科大学第四附属医院 | Medicine for treating heart yin deficiency type atrial fibrillation |
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Owner name: SHENZHEN CITY BEIKELIAN MEDICINE SCIENCE CO., LTD Free format text: FORMER OWNER: XINGER MEDICINE TECHNOLOGY DEVELOPMENT SCI. + TECH. CO., LTD., SHENZHEN CITY Effective date: 20070727 |
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Effective date of registration: 20070727 Address after: Shenzhen City, Guangdong province 518029 CaiTian road Futian Futian District District No. 5015 Bank of China Tower, block B floor 8 Patentee after: Shenzhen Beikelian Pharmaceutical Science-Technology Co., Ltd. Address before: Shenzhen City, Guangdong province 518031 step Road No. 2 Trade Union Mansion, block B floor 6 Patentee before: Xinger Medicine Technology Development Sci. & Tech. Co., Ltd., Shenzhen City |
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Granted publication date: 20060531 Termination date: 20191021 |
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