CN109260426A - A kind of disease eliminating powder junction pain-stopping external use Chinese medicine and its preparation method and application - Google Patents
A kind of disease eliminating powder junction pain-stopping external use Chinese medicine and its preparation method and application Download PDFInfo
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- CN109260426A CN109260426A CN201811512860.8A CN201811512860A CN109260426A CN 109260426 A CN109260426 A CN 109260426A CN 201811512860 A CN201811512860 A CN 201811512860A CN 109260426 A CN109260426 A CN 109260426A
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- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of disease eliminating powder junction pain-stopping external use Chinese medicines and its preparation method and application, the disease eliminating powder junction pain-stopping external use Chinese medicine is by 20~41 parts of gamboge, 74~96 parts of turmeric, 33~55 parts of curcuma zedoary, 20~40 parts of the root of Dahurain angelica, 9~28 parts of the seed of garden balsam, 9~25 parts of radix semiaquilegiae and 2~6 parts of semen momordicae, it is made in accordance with the following methods: above-mentioned all medicinal powder being broken into fine powder and adds honey, curcuma zedoary endogenetic fungus strain and/or turmeric endogenetic fungus strain, stirring, fermentation, preparation to get.Disease eliminating powder junction pain-stopping external use Chinese medicine of the present invention has the function of disease eliminating powder junction, rotten sore of dispelling, attacks poison analgesic, it can be used for treating the diseases such as fibroid, ovarian cyst, Breast Nodules, vaginitis, pelvic inflammation mass, thyroid hyperplasia tubercle, hyperplasia of prostate, prostatitis, diabetes and diabetic arterial occlusion of lower extremities, it can also relieve pain, especially cancer pain, good effect, preparation method is simple, is conducive to promote and apply.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to it is a kind of treat because of blood stasis caused by a lump in the abdomen causing distension and pain class disease external application in
Medicine and its preparation method and application.
Background technique
Lumps in the chest and abdomen is the agglomeration of " tangible visible " or " false object forming ", is a kind of disease concept in traditional Chinese medicine, can
Slipped with showing as mass located in the upper or lower abdomen, renal mass, ulcer, goiter, scrofula, muscle, the diseases such as mammary cancer, also include modern diseases such as hyperplasia of prostate,
Ovarian cyst, fibroid, benign or malignant tumour and arteriovenous embolism etc..Phlegm wet, hemostasis, the stagnation of the circulation of vital energy are the substance bases of " tangible "
Plinth.The formation of Huan person's lumps in the chest and abdomen is a healthy tendency consume, with the passing of time enters network into hard process, needs using with stronger eliminating mass
The drug of mass-dissipating efficacy is treated.From the prior art as can be seen that having been achieved with unification on this problem, but curative effect also needs
Improve.The prior art often uses resolving hard lump or the oral prescription of activating microcirculation and removing stasis medicinal to treat all a lump in the abdomen causing distension and pain disease types,
The efficacy of a drug is difficult through affected part, and curative effect is to be worth discussion.
In the prior art, Patent No. ZL2004 10043648.3, entitled " the dissipating bind breast illness cream applied by this enterprise
And preparation method thereof " patent disclose a kind of for treating the pharmaceutical composition of gynaecology's breast illness disease, be by curcuma zedoary, white
The root of Dahurian angelica, the seed of garden balsam, semen momordicae and turmeric according to the required weight in addition to curcuma zedoary and turmeric are ground into fine powder, remaining each taste extracts through ethyl alcohol,
Concentration, mixing, coating and etc. emplastrum is made.The pharmaceutical composition have it is curative for effect, have no toxic side effect, quality standard can
Control, be easy to the characteristics of absorbing, but have a disadvantage in that prepared drug a lump in the abdomen causing distension and pain to obstinate, especially fibroid,
For hyperplasia of prostate and tumour etc., disease eliminating powder junction and analgesic effect still cannot effectively meet clinical needs, and need largely to make
With.
The present invention is to be directed to the deficiencies in the prior art, is dedicated to providing a kind of medicine and lacks special, the curative for effect treatment of power
The external application Chinese medicine and its preparation method and application for class disease that a lump in the abdomen causing distension and pain.
Summary of the invention
The object of the present invention is to provide a kind of disease eliminating powder junction pain-stopping external use Chinese medicines and its preparation method and application.
On the one hand, the present invention provides a kind of disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation, by unprocessed resin of Garcinia morella,
Turmeric, curcuma zedoary, the root of Dahurain angelica, the seed of garden balsam, radix semiaquilegiae, seven taste Chinese medicine of semen momordicae are made through the fermentation of Chinese medicine endogenetic fungus.
Preferably, the Chinese medicine endogenetic fungus is or mixtures thereof curcuma zedoary endogenetic fungus, turmeric endogenetic fungus；
Preferably, the curcuma zedoary endogenetic fungus, turmeric endogenetic fungus are prepared as follows, fresh curcuma zedoary rhizome or ginger
Xanthorrhiza stem cleans up, and using disinfected paper napkin suck dry moisture, rinses 30-75s using 75% ethyl alcohol under gnotobasis, use is sterile
Water rinses 3-5 times, rinses 3-5min using 10% sodium hypochlorite, rear to use aseptic water washing 3-5 times, uses sterilizing surgical scissors
Curcuma zedoary rhizome or turmeric rhizome are cut into about 0.5 × 0.5cm2Small pieces, be placed on potato dextrose medium, in 30
DEG C sterile culture case culture is reinoculated on potato dextrose medium to mycelia, picking mycelia tip is grown, and is repeated pure
Be inoculated on potato glucose slant medium after changing 3-5 times cultivate it is spare after mycelia to growing；Preferably, under gnotobasis
60s is rinsed using 75% ethyl alcohol, using aseptic water washing 4 times, 4min is rinsed using 10% sodium hypochlorite, is rushed afterwards using sterile water
Wash 4 times, be inoculated on potato glucose slant medium after repeating purifying 5 times cultivate it is spare after mycelia to growing.
Preferably, the disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation by 20-41 parts unprocessed resin of Garcinia morella,
74-96 parts of turmeric, 33-55 parts of curcuma zedoary, 20-40 parts of the root of Dahurain angelica, 9-28 parts of the seed of garden balsam, 9-25 parts of radix semiaquilegiae and 2-6
The semen momordicae of part is made；
It is furthermore preferred that the disease eliminating powder junction pain-stopping external use Chinese medicine of the Chinese medicine endogenetic fungus fermentation is by 36 parts of unprocessed resin of Garcinia morella, turmeric
75 parts, 39 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, 17 parts impetuous, 16 parts of radix semiaquilegiae and 4 parts of semen momordicae are made, or by 30 parts of unprocessed resin of Garcinia morella, ginger
80 parts yellow, 44 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, 18 parts impetuous, 17 parts of radix semiaquilegiae and 4 parts of semen momordicae are made；Or by 25 parts of unprocessed resin of Garcinia morella,
90 parts of turmeric, 37 parts of curcuma zedoary, 25 parts of the root of Dahurain angelica, 20 parts impetuous, 20 parts of radix semiaquilegiae and 3 parts of semen momordicae are made.
Preferably, the disease eliminating powder junction pain-stopping external use Chinese medicine of the Chinese medicine endogenetic fungus fermentation is selected from emplastrum, paste, film
Agent, ointment, cream, powder, gelling agent, aerosol etc.；It is furthermore preferred that the disease eliminating powder junction of the Chinese medicine endogenetic fungus fermentation
Pain-stopping external use Chinese medicine is selected from emplastrum, paste, film, ointment, cream etc.；Most preferably, the Chinese medicine endogenetic fungus hair
The disease eliminating powder junction pain-stopping external use Chinese medicine of ferment is emplastrum.
It is also another object of the present invention to provide a kind of disease eliminating powder junction pain-stopping external use Chinese medicines of Chinese medicine endogenetic fungus fermentation
Preparation method, comprising the following steps:
A. take the unprocessed resin of Garcinia morella of formula ratio, turmeric, curcuma zedoary, the root of Dahurain angelica, the seed of garden balsam, radix semiaquilegiae, semen momordicae pulverizing medicinal materials at fine powder,
60-120 mesh is crossed, it is spare；
B. 350-550 parts of honey are taken, heating dissolves, and sieving removes impurity while hot, and above-mentioned fine powder and Chinese medicine is added when 60 DEG C
Endogenetic fungus strain, stirring 10-30 minute is to uniformly mixed；
C. Laurocapram 3% is added, stirs 20-40 minutes, sets in closed container and ferments 7 days in 30-50 DEG C；
D. the disease eliminating powder junction pain-stopping external use Chinese medicine that preparation ferments to get Chinese medicine endogenetic fungus of the present invention.
Preferably, the Chinese medicine endogenetic fungus strain is or mixtures thereof curcuma zedoary endogenetic fungus, turmeric endogenetic fungus；
Preferably, the disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation by 20-41 parts unprocessed resin of Garcinia morella,
74-96 parts of turmeric, 33-55 parts of curcuma zedoary, 20-40 parts of the root of Dahurain angelica, 9-28 parts of the seed of garden balsam, 9-25 parts of radix semiaquilegiae and 2-6
The semen momordicae of part is made；
It is furthermore preferred that the disease eliminating powder junction pain-stopping external use Chinese medicine of the Chinese medicine endogenetic fungus fermentation is by 36 parts of unprocessed resin of Garcinia morella, turmeric
75 parts, 39 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, 17 parts impetuous, 16 parts of radix semiaquilegiae and 4 parts of semen momordicae are made, or by 30 parts of unprocessed resin of Garcinia morella, ginger
80 parts yellow, 44 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, 18 parts impetuous, 17 parts of radix semiaquilegiae and 4 parts of semen momordicae are made；Or by 25 parts of unprocessed resin of Garcinia morella,
90 parts of turmeric, 37 parts of curcuma zedoary, 25 parts of the root of Dahurain angelica, 20 parts impetuous, 20 parts of radix semiaquilegiae and 3 parts of semen momordicae are made.
Preferably, the disease eliminating powder junction pain-stopping external use Chinese medicine of the Chinese medicine endogenetic fungus fermentation is selected from emplastrum, paste, film
Agent, ointment, cream, powder, gelling agent, aerosol etc.；It is furthermore preferred that the disease eliminating powder junction of the Chinese medicine endogenetic fungus fermentation
Pain-stopping external use Chinese medicine is selected from emplastrum, paste, film, ointment, cream etc.；Most preferably, the Chinese medicine endogenetic fungus hair
The disease eliminating powder junction pain-stopping external use Chinese medicine of ferment is emplastrum；
Preferably, in the step a, pulverizing medicinal materials are sieved with 100 mesh sieve at fine powder, spare；Honey is taken in the step b
450-500 parts, 80 meshes are crossed while hot and remove impurity, above-mentioned fine powder and Chinese medicine endogenetic fungus strain are added when 60 DEG C, stirs 20 points
Clock to be uniformly mixed；Laurocapram 3% is added in the step c, stirs 30 minutes, sets in closed container and is sent out in 30-50 DEG C
Ferment 7 days；It in the step d, is formed with mold, after non-woven wraps, is placed on skin recovery film for medical use to get in Chinese medicine of the present invention
The disease eliminating powder junction pain relieving plaster paste of raw fungi fermentation.
It is also another object of the present invention to provide a kind of Chinese medicine endogenetic fungus fermentation materials in preparation treatment a lump in the abdomen causing distension and pain class disease
Purposes in the external application Chinese medicine of disease.
Preferably, the Chinese medicine endogenetic fungus fermentation material is by unprocessed resin of Garcinia morella, turmeric, curcuma zedoary, the root of Dahurain angelica, the seed of garden balsam, radix semiaquilegiae, wood
Seven taste Chinese medicine of soft-shelled turtle is made through the fermentation of Chinese medicine endogenetic fungus；It is furthermore preferred that by 20-41 parts of unprocessed resin of Garcinia morella, 74-96 parts of turmeric,
33-55 parts of curcuma zedoary, 20-40 parts of the root of Dahurain angelica, 9-28 parts of the seed of garden balsam, 9-25 parts of radix semiaquilegiae and 2-6 parts of semen momordicae is made；
Most preferably, by 36 parts of unprocessed resin of Garcinia morella, 75 parts of turmeric, 39 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, 17 parts impetuous, 16 parts of radix semiaquilegiae and Momordica cochinchiensis
4 parts of son is made, or by 30 parts of unprocessed resin of Garcinia morella, 80 parts of turmeric, 44 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, 18 parts impetuous, 17 parts of radix semiaquilegiae and wood
4 parts of soft-shelled turtle are made；Or by 25 parts of unprocessed resin of Garcinia morella, 90 parts of turmeric, 37 parts of curcuma zedoary, 25 parts of the root of Dahurain angelica, 20 parts impetuous, 20 parts of radix semiaquilegiae and
3 parts of semen momordicae are made.
Preferably, the Chinese medicine endogenetic fungus is selected from or mixtures thereof curcuma zedoary endogenetic fungus, turmeric endogenetic fungus；
It is preferably, described that a lump in the abdomen causing distension and pain that class disease is selected from: Fu Nv Disorder lump in the abdomen, breast illness, the moon caused by qi depression to blood stasis, phlegm and blood stasis
Through uncomfortable, dysmenorrhea, stagnation of blood stasis, phlegm, which agglutinates, gathers caused goiter, the retention of urine, the diabetes and diabetes limb artery of blood stasis
Occlude disease, pain caused by blood stasis etc..It is preferably, described that a lump in the abdomen causing distension and pain that class disease is selected from: qi depression to blood stasis, phlegm and blood stasis institute
Lump in the Fu Nv Disorder lump in the abdomen of cause, breast illness, irregular menstruation, dysmenorrhea symptoms include lower abdomen block, breast, with pain, blockage of menstruation, warp
Phase abdominal pain refusing to pressure has clot, fibroid, ovarian cyst, Breast Nodules, and stagnation of blood stasis, phlegm, which agglutinate, gathers caused goiter, infirmity
Close symptoms include neck region lump, with pain, it is swollen it is bored feel suffocated, dysuria or short puckery, the small distention and fullness in the abdomen of frequency, thyroid hyperplasia tubercle,
Hyperplasia of prostate, prostatitis etc. are shown in above-mentioned patient, cancer pain etc..
We have disease eliminating powder junction, go rotten sore, attack the function of poison analgesic.Unprocessed resin of Garcinia morella is monarch drug in a prescription in side, enters liver, spleen two
Had and attack malicious phagedenoma, the effect of blood-breaking dissipating bind, " this is through meeting original " calls its " property poison, and can attack poison "." Haiyao Bencao, Oversea Materia Medica " calls it
" detumescence detoxification, stop blooding desinsection.Control swollen ulcer drug, stubborn dermatitis malignant sore "." detailed outline is picked up any lost article from the road " calls its " controlling ulcer, detoxification of stopping blooding "." lifesaving
The sea of bitterness " " control all nameless sores or boils and counterpart carbuncle on the back: drop flower liquor, mill unprocessed resin of Garcinia morella are applied, are not stopped deposited disinfection side's record unprocessed resin of Garcinia morella
It." therefore be the monarch drug in a prescription of we.Turmeric, curcuma zedoary, the seed of garden balsam are ministerial drug in side.Turmeric, it is logical that pungent scattered hardship lets out temperature, cures mainly stagnation of QI and blood
All cards.Curcuma zedoary, blood-breaking dispersing blood stasis, promoting qi circulation and relieving pain, Zhu Zhi abdominal mass and lump, vim and vigour are pained, eating accumulation, the illnesss such as abdominal distention.It is anxious
Temper, pungent scattered temperature is logical, impatient speed, is apt to the blood-breaking row stasis of blood, resolving hard lump.It therefore is altogether ministerial drug.The root of Dahurain angelica takes its fragrance to walk to alter.Momordica cochinchiensis
Son, it is kind to control carbuncle swells furunculosis, scrofula.Radix semiaquilegiae is clearing heat and detoxicating, dispersing swelling and dissipating binds.Therefore the root of Dahurain angelica, semen momordicae, the assistant that radix semiaquilegiae is we
Medicine.Complete square compatibility 5, it is special that medicine lacks power, receives disease eliminating powder junction, the function of promoting qi circulation and relieving pain, is suitable for that a lump in the abdomen causing distension and pain, qi depression to blood stasis disease.
Although unprocessed resin of Garcinia morella pharmacological activity is stronger, toxicity is still be hard to avoid the problem of.During the present invention uses
The method of medicine microbial fermentation reduces its toxicity.Fermentation is a kind of traditional concocting method, such as Pien Tze Huang, medicinal fermented mass, Chinese eaglewood medicated leaven, light
Fermented soya bean, Rhizoma Pinelliae Fermentata, red yeast rice, malt are also all the drugs formed by fermentation.One side microorganism fermentation process effectively drops
The toxic side effect of low unprocessed resin of Garcinia morella；On the other hand, the generation of secondary metabolite or noval chemical compound is conducive to the promotion of drug effect.It is modern
Science and technology has grasped the mechanism of action that traditional Chinese medicine fermentation processes substantially, and reason is mainly the biology for relying on microorganism
Conversion, traditional Chinese medicine fermentation be by using the mode of solid spontaneous fermentation, using microorganism in environment for example mould, saccharomycete,
Bacterium etc. carry out multiple bacteria compound fermentation, but participated in spontaneous fermentation fermentation species and quantity will receive environment and season
The influence of variation is saved, and then influences the quality of ferment effect and processed product.The zymotechnique of this preparation innovatively uses prescription
Or mixtures thereof natural endogenetic fungus of two middle curcuma zedoary, turmeric medicinal materials is used as fermenting microbe, and unprocessed resin of Garcinia morella is enabled to be attenuated increasing
Effect, mild reaction condition, Chinese materia medica preparation efficiently, low toxicity, low-residual.
Beneficial effects of the present invention:
Disease eliminating powder junction pain-stopping external use Chinese medicine of the invention has disease eliminating powder junction, blood circulation, promoting qi circulation and relieving pain effect.For gas
Fu Nv Disorder lump in the abdomen, breast illness, irregular menstruation, dysmenorrhea caused by stagnant blood stasis, phlegm and blood stasis；Symptoms include lump in lower abdomen block, breast, with
Pain, blockage of menstruation, bellyache in menstrual period tenderness have clot；Fibroid, ovarian cyst, Breast Nodules.There is the goitre that disappears to dissipate simultaneously
Knot, the logical effect closed of stagnation resolvation.Agglutinate for stagnation of blood stasis, phlegm and gather caused goiter, the retention of urine symptoms include neck region lump, with pain,
It is swollen bored to feel suffocated；Dysuria or frequency are short puckery, small distention and fullness in the abdomen；Thyroid hyperplasia tubercle, hyperplasia of prostate, prostatitis etc. are shown in
Above-mentioned patient.For diseases such as the diabetes of blood stasis and diabetic arterial occlusion of lower extremities.For as caused by blood stasis
Pain has relaxation effect, especially stronger to cancer pain relaxation effect.
Disease eliminating powder junction pain-stopping external use Chinese medicinal preparation method of the invention is simple, is suitble to industrialized production, is conducive to promote and apply.
Specific embodiment
The present invention is described below in more detail to facilitate the understanding of the present invention.
A kind of embodiment 1: Chinese medicine endogenetic fungus fermentation disease eliminating powder junction pain-stopping plaster
It ferments to obtain through curcuma zedoary endogenetic fungus by the raw material of following weight parts: 36 parts of unprocessed resin of Garcinia morella, 75 parts of turmeric, curcuma zedoary 39
Part, 30 parts of the root of Dahurain angelica, impetuous 17 parts, 16 parts of radix semiaquilegiae, 4 parts of semen momordicae, 450 parts of honey, Laurocapram 3%.According to lower section
Method is prepared:
A. take the unprocessed resin of Garcinia morella of formula ratio, turmeric, curcuma zedoary, the root of Dahurain angelica, the seed of garden balsam, radix semiaquilegiae, semen momordicae pulverizing medicinal materials at fine powder,
80 meshes are crossed, it is spare；
B. honey is taken, heating dissolves, and sieving removes impurity while hot, and above-mentioned fine powder and curcuma zedoary endogenetic fungus bacterium are added when 60 DEG C
Kind, stirring 10-30 minute is to uniformly mixed；
C. Laurocapram is added, stirs 30 minutes, sets in closed container and ferments 7 days in 30-50 DEG C；
D. preparation is formed with mold, after non-woven wraps, be placed on skin recovery film for medical use to get.
A kind of embodiment 2: Chinese medicine endogenetic fungus fermentation disease eliminating powder junction pain-stopping plaster
It ferments to obtain through turmeric endogenetic fungus by the raw material of following weight parts: 36 parts of unprocessed resin of Garcinia morella, 75 parts of turmeric, curcuma zedoary 39
Part, 30 parts of the root of Dahurain angelica, impetuous 17 parts, 16 parts of radix semiaquilegiae, 4 parts of semen momordicae, 450 parts of honey, Laurocapram 3%.According to lower section
Method is prepared:
A. take the unprocessed resin of Garcinia morella of formula ratio, turmeric, curcuma zedoary, the root of Dahurain angelica, the seed of garden balsam, radix semiaquilegiae, semen momordicae pulverizing medicinal materials at fine powder,
80 meshes are crossed, it is spare；
B. honey is taken, heating dissolves, and sieving removes impurity while hot, and above-mentioned fine powder and turmeric endogenetic fungus bacterium are added when 60 DEG C
Kind, stirring 10-30 minute is to uniformly mixed；
C. Laurocapram is added, stirs 30 minutes, sets in closed container and ferments 7 days in 30-50 DEG C；
D. preparation is formed with mold, after non-woven wraps, be placed on skin recovery film for medical use to get.
A kind of embodiment 3: Chinese medicine endogenetic fungus fermentation disease eliminating powder junction pain-stopping plaster
It is obtained by the raw material of following weight parts through curcuma zedoary endogenetic fungus and turmeric endogenetic fungus mixed fermentation: unprocessed resin of Garcinia morella 36
Part, 75 parts of turmeric, 39 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, impetuous 17 parts, 16 parts of radix semiaquilegiae, 4 parts of semen momordicae, 450 parts of honey, laurel nitrogen
Tall and erect ketone 3%.It is prepared in accordance with the following methods:
A. take the unprocessed resin of Garcinia morella of formula ratio, turmeric, curcuma zedoary, the root of Dahurain angelica, the seed of garden balsam, radix semiaquilegiae, semen momordicae pulverizing medicinal materials at fine powder,
80 meshes are crossed, it is spare；
B. honey is taken, heating dissolves, and sieving removes impurity while hot, and above-mentioned fine powder and curcuma zedoary endogenetic fungus bacterium are added when 60 DEG C
Kind and turmeric endogenetic fungus strain, stirring 10-30 minute is to uniformly mixed；
C. Laurocapram is added, stirs 30 minutes, sets in closed container and ferments 7 days in 30-50 DEG C；
D. preparation is formed with mold, after non-woven wraps, be placed on skin recovery film for medical use to get.
A kind of embodiment 4: Chinese medicine endogenetic fungus fermentation disease eliminating powder junction pain-stopping plaster
It is obtained by the raw material of following weight parts through curcuma zedoary endogenetic fungus and turmeric endogenetic fungus mixed fermentation: unprocessed resin of Garcinia morella 30
Part, 80 parts of turmeric, 44 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, impetuous 18 parts, 4 parts of 17 parts of radix semiaquilegiae, semen momordicae honey 480；Laurel nitrogen is tall and erect
Ketone 3% is prepared according to 3 method of embodiment.
A kind of embodiment 5: Chinese medicine endogenetic fungus fermentation disease eliminating powder junction pain-stopping plaster
It is obtained by the raw material of following weight parts through curcuma zedoary endogenetic fungus and turmeric endogenetic fungus mixed fermentation: unprocessed resin of Garcinia morella 25
Part, 90 parts of turmeric, 37 parts of curcuma zedoary, 25 parts of the root of Dahurain angelica, impetuous 20 parts, 20 parts of radix semiaquilegiae, 550 parts of 3 parts of semen momordicae, honey laurel nitrogen
Tall and erect ketone 3% is prepared according to 3 method of embodiment.
Effect example 1: stimulation of the fermentation front and back disease eliminating powder junction pain-stopping plaster to family's rabbit skin
1.1 experimental methods:
8%Na is used before test2S (distilled water preparation) sloughs rabbit back spinal two sides hair, and epilating area area is about
150cm2.After depilation for 24 hours, " # " shape wound, wound are drawn in damaged skin group back part of animal two sides hair removal section aseptic operation blade
About 4cm is spaced 1.5cm, oozes out blood.Back hair removal section is smeared disease eliminating powder junction and is stopped on the left of complete and damaged group rabbit
Pain patch cream 4g/ only, then smear fermentation prodrug 4g/ and only compare by right side back hair removal section.Groups of animals smear after be coated with oilpaper,
Gauze is fixed, and is smeared and is removed test medicine and matrix with wet water for 24 hours, is observed local situations such as whether there is or not erythema and oedema, is continuously given
It medicine 7 days, smears in the same way daily and is administered and is observed.After last dose removes test medicine, then continuous sight day by day
Examine seven days, except observation smear area skin whether there is or not erythema and oedema outside and meanwhile to observe cutaneous pigmentation, blutpunkte, skin soft and moist
Situation etc. is observed using two sides skin self-contrast method, and evaluates skin irritation intensity, experiment by skin irritatin standards of grading
As a result referring to table 1, wherein skin irritatin standards of grading are as follows:
1.2 experimental result
Table 1: to the stimulation of family's rabbit skin before and after pharmaceutical fermentation
Note: () is own control side skin of back number
Table 1 is the result shows that in 7 days be administered, and the prodrug group check plot skin that ferments was in 1~7 day visible erythema, after fermentation
Medicine group skin Non Apparent Abnormality, from the 8th day, after removing test medicine, prodrug group erythema of fermenting and oedema gradually disappear
It moves back, and other each group man rabbit skins are showed no erythema and oedema, equal score value is 0, and coating area skin non-pigment is calm, bleeding
It point and soft and moist sexually revises.These results suggested that have slight stimulation (mean scores 0.5~2.99) effect to skin before pharmaceutical fermentation, and
Drug has no stimulation of the skin after fermentation.Therefore, Chinese medicine endogenetic fungus fermentation can reduce disease eliminating powder junction pain-stopping plaster to skin
Irritation.
Effect example 2: disease eliminating powder junction pain-stopping plaster is to a lump in the abdomen causing distension and pain, the therapeutic effect of qi depression to blood stasis patient
2.1 experimental drug
Drug of the present invention: 3 disease eliminating powder junction pain-stopping plaster of the embodiment of the present invention；
Ferment prodrug: preparing according to 3 method of embodiment, difference is not add fermenting microbe.
Positive control medicine: RUPIXIAO TIEGAO (Heilungkiang He Xiang pharmaceutical Co. Ltd, authentication code: national drug standard
Z20040073, lot number 160305).
2.2 experimental method
2.2.1 case selection standard
120 patients with uterin leiomyoma patients, average age 43.6 ± 7.6 years old, respectively carry out in, doctor trained in Western medicine diagnosis, according to ultrasound diagnosis
It is diagnosed as intramural myoma, subserous myome or fleshy polyp person, and has that a lump in the abdomen causing distension and pain, qi depression to blood stasis etc. meets Syndrome Differentiation of Chinese Medicine
Card person, exclusion not yet makes a definite diagnosis, suspicious merging myometrial gland patient, the gestational period or breast feeding women patient.
2.2.2 treatment method
120 patients with uterin leiomyoma patients are randomly divided into three group treatments, wherein and positive controls 40, treatment group before fermenting
40, treatment group 40, positive controls select prescription RUPIXIAO TIEGAO in the prior art, treatment group and treatment group before fermenting
Relative medicine is selected, application method is to be pasted on affected part, one time 1 patch, 2 times a day.Menstrual period withdraw, 30 days as a treatment course, even
2 courses for the treatment of of continuous treatment.The total effective rate of each group drug is counted, specific experiment result is referring to table 2, and wherein the standard of curative effect evaluation is such as
Under:
Curative effect is determined according to new Chinese medicine guideline of clinical investigations, in which:
Cure: myomata disappears, and clinical symptoms disappear；
Effective: B ultrasound shows that myomata reduces 15mm or more, clinical symptom relief or disappearance；
Effective: B ultrasound shows that myomata reduces 0.5-1.5mm, and clinical symptoms are unchanged without improvement or myomata；
Invalid: myomata is unchanged or increases, and clinical symptoms are without improvement.
2.3 experimental results:
It is handled using SPSS13.00 software, measurement data is examined with t, and enumeration data Chi-square Test, P < 0.05 is difference
There is conspicuousness.
Therapeutic effect of the disease eliminating powder junction pain-stopping plaster of the present invention of table 2 to fibroid
| The course for the treatment of | Sample size | It cures | Effectively | It is effective | Total effective quantity | In vain | Total effective rate (%) |
| Treatment group | 40 | 24 | 11 | 2 | 37 | 3 | 92.5 |
| Treatment group before fermenting | 40 | 13 | 15 | 5 | 33 | 7 | 82.5 |
| Positive controls | 40 | 6 | 18 | 5 | 29 | 11 | 72.5 |
2 experimental result of table, it is shown that disease eliminating powder junction pain-stopping plaster of the present invention is obviously high for the total effective rate of fibroid
In positive control drug RUPIXIAO TIEGAO, and it is more notable better than positive controls to cure case quantity, it is shown that the present invention disappears
Disease eliminating stagnation to stop pain emplastrum achieves fibroid excellent therapeutic effect, relative to treatment group before fermenting, eliminating mass of the present invention
Eliminating stagnation to stop pain emplastrum, which also has the total effective rate of fibroid, to be significantly improved, and it is significantly excellent similarly to cure case quantity
The control group before fermenting shows the present invention by the fermentation using curcuma zedoary endogenetic fungus and turmeric endogenetic fungus, significantly
Improve the therapeutic effect of disease eliminating powder junction pain-stopping plaster.
Typical case
1, Mr. Wang, female, 32 years old, private prosecution abdominal pain, the soreness of waist were once done ultrasound diagnosis and are shown more than May: left side attachment area is visible 1 ×
3.6cm no echo area.After giving infusion 3 periods of anti-inflammatory in menstrual period, check B ultrasound adnexal cyst has no diminution, with pale tongue purple whitish tongue
Greasy, deeptensepulse is sliding.Dialectical for the stagnation of the circulation of vital energy, a lump in the abdomen causing distension and pain, controls with disease eliminating powder junction, activating microcirculation and removing stasis medicinal.After sticking disease eliminating powder junction pain-stopping plaster 60 days
B ultrasound is checked, bilateral attachment area is shown no obvious abnormalities.Abdominal pain, the soreness of waist disappear.
2, Mr. Li, female, 35 years old, from cause anger amenorrhea 2 months, lower abdominal distention pain tenderness, irritable, chest side of body was swollen
Full, belch is sighed, and tongue purple secretly has ecchymosis, and deep wiry pulse is strong.Dialectical is qi depression to blood stasis, a lump in the abdomen causing distension and pain, is controlled with disease eliminating powder junction, dissolving stasis
Promoting menstruation.After sticking disease eliminating powder junction pain-stopping plaster 20 days, menstrual onset, all diseases mitigate, and hyper-menorrhea has block, again with this medicine 20 after
It, above-mentioned symptom disappears, and does not recur again.
3, it is high so-and-so, female, 63 years old, right Upper abdominal pain was yellow with mesh, body is yellow, yellow urine, and conscious right upper quadrant of the abdomen dull pain, shoulder is carried on the back to the right
Portion radiation, seriously affect spirit, sleep diet it is poor, stool be in clay color, upper right abdomen can be laid one's hand on and 1 5cm × 8cm mass, in matter
Deng tenderness is obvious.CT is reported: gallbladder cancer, hepatic tissue infiltration involvement around cyst wall, hepatic hilar region enlargement of lymph nodes transfer.Take morphine
Controlled release tablet 10mg can be relieved pain partially, deactivated then sharp ache.The patch of disease eliminating powder junction pain-stopping plaster 5 is given, mass pain district is affixed on,
Pain is relieved after 50 minutes, and analgesia duration was up to 20 hours.It every dressing in 24 hours 1 time, is used in conjunction 14 days, patient's spirit
It is clearly better, sleep can.
4, Xu certain, female, 80 years old, diabetes 16 years, right the 2nd toe nigrescence of foot ulcer, pain, was sent out cool, right pulsation of foot dorsal artery
Weaken, red tip of tongue, yellow thick greasy, the slippery in tongue fur root.Diagnosis: quenching one's thirst, the gangrene of finger or toe, diabetes.B ultrasound: double lower limb artery sclerosis, through pancreas
After island element, enteric coated aspirin treatment are invalid.Dialectical: a lump in the abdomen causing distension and pain caused by blood stasis.It controls and is relieved pain with disease eliminating powder junction.Stick eliminating mass
Eliminating stagnation to stop pain emplastrum, pain disappears from the 2nd day, has the outflow of black blood at ulcer, all diseases are mitigated after 14 days, at ulcer
There is bright red blood outflow, have and newly granulate, digital ulcer is obviously reduced after sticking 30 days.
The foregoing describe the preferred embodiment for the present invention, and however, it is not to limit the invention.Those skilled in the art couple
Embodiment disclosed herein can carry out the improvements and changes without departing from scope and spirit.
Claims (10)
1. a kind of disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation, it is characterised in that by unprocessed resin of Garcinia morella, turmeric, cowherb
Art, the root of Dahurain angelica, the seed of garden balsam, radix semiaquilegiae, seven taste Chinese medicine of semen momordicae are made through the fermentation of Chinese medicine endogenetic fungus.
2. the disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation according to claim 1, which is characterized in that institute
Stating Chinese medicine endogenetic fungus is or mixtures thereof curcuma zedoary endogenetic fungus, turmeric endogenetic fungus.
3. the disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation according to claim 2, which is characterized in that institute
State the mixture that Chinese medicine endogenetic fungus is curcuma zedoary endogenetic fungus, turmeric endogenetic fungus.
4. the disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation according to claim 1-3, special
Sign is, by 20-41 parts of unprocessed resin of Garcinia morella, 74-96 parts of turmeric, 33-55 parts of curcuma zedoary, 20-40 parts of the root of Dahurain angelica, 9-28 parts of urgency
Temper, 9-25 parts of radix semiaquilegiae and 2-6 parts of semen momordicae are made.
5. the disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation according to claim 4, which is characterized in that by
36 parts of unprocessed resin of Garcinia morella, 75 parts of turmeric, 39 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, 17 parts impetuous, 16 parts of radix semiaquilegiae and 4 parts of semen momordicae are made, or
It is made of 30 parts of unprocessed resin of Garcinia morella, 80 parts of turmeric, 44 parts of curcuma zedoary, 30 parts of the root of Dahurain angelica, 18 parts impetuous, 17 parts of radix semiaquilegiae and 4 parts of semen momordicae,
Or by 25 parts of unprocessed resin of Garcinia morella, 90 parts of turmeric, 37 parts of curcuma zedoary, 25 parts of the root of Dahurain angelica, 20 parts impetuous, 20 parts of radix semiaquilegiae and 3 parts of semen momordicae systems
At.
6. the disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation according to claim 1-5, special
Sign is, the disease eliminating powder junction pain-stopping external use Chinese medicine of the Chinese medicine endogenetic fungus fermentation be selected from emplastrum, paste, film, ointment,
Cream, powder, gelling agent, aerosol；Preferably, the disease eliminating powder junction pain-stopping external use Chinese medicine choosing of the Chinese medicine endogenetic fungus fermentation
From emplastrum, paste, film, ointment, cream；Most preferably, the disease eliminating powder junction analgesic of the Chinese medicine endogenetic fungus fermentation
External application Chinese medicine is emplastrum.
7. the preparation side of the disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation described in any one of claims 1-6
Method, it is characterised in that the following steps are included:
A. take the unprocessed resin of Garcinia morella of formula ratio, turmeric, curcuma zedoary, the root of Dahurain angelica, the seed of garden balsam, radix semiaquilegiae, semen momordicae pulverizing medicinal materials at fine powder, mistake
60-120 mesh, it is spare；
B. 350-550 parts of honey are taken, heating dissolves, and sieving removes impurity while hot, is added in above-mentioned fine powder and Chinese medicine when 60 DEG C raw
Fungi strain, stirring 10-30 minute is to uniformly mixed；
C. Laurocapram 3% is added, stirs 20-40 minutes, sets in closed container and ferments 7 days in 30-50 DEG C；
D. the disease eliminating powder junction pain-stopping external use Chinese medicine that preparation ferments to get Chinese medicine endogenetic fungus.
8. the preparation method of the disease eliminating powder junction pain-stopping external use Chinese medicine of Chinese medicine endogenetic fungus fermentation according to claim 7,
It is characterized in that, in the step a, pulverizing medicinal materials are sieved with 100 mesh sieve at fine powder, spare；Honey 450-500 is taken in the step b
Part, 80 meshes are crossed while hot and remove impurity, above-mentioned fine powder and Chinese medicine endogenetic fungus strain are added when 60 DEG C, are extremely mixed within stirring 20 minutes
Uniformly；Laurocapram 3% is added in the step c, stirs 30 minutes, sets in closed container and ferments 7 days in 30-50 DEG C；Institute
It states in step d, is formed with mold, after non-woven wraps, be placed in disappearing to get the fermentation of Chinese medicine endogenetic fungus on skin recovery film for medical use
Disease eliminating stagnation to stop pain emplastrum.
9. unprocessed resin of Garcinia morella, turmeric, curcuma zedoary, the root of Dahurain angelica, the seed of garden balsam, radix semiaquilegiae, seven taste Chinese medicine of semen momordicae are through Chinese medicine endogenetic fungus fermentation material
Purposes in the external application Chinese medicine of preparation treatment a lump in the abdomen causing distension and pain class disease.
10. purposes according to claim 9, which is characterized in that a lump in the abdomen causing distension and pain the class disease is selected from qi depression to blood stasis, phlegm-blood stasis
Mutually Fu Nv Disorder lump in the abdomen, breast illness, irregular menstruation, dysmenorrhea caused by knot, stagnation of blood stasis, phlegm, which agglutinates, gathers caused goiter, the retention of urine, blood stasis
Diabetes and diabetic arterial occlusion of lower extremities disease, pain caused by blood stasis etc..
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112791167A (en) * | 2021-01-12 | 2021-05-14 | 杭州青蜓遵序堂健康管理有限公司 | Preparation process of pain-relieving and stasis-removing hydrogel patch |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593599A (en) * | 2004-06-23 | 2005-03-16 | 齐齐哈尔鹤翔制药有限责任公司 | Ointment for dispersing breast nodules and preparation method thereof |
-
2018
- 2018-12-11 CN CN201811512860.8A patent/CN109260426B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593599A (en) * | 2004-06-23 | 2005-03-16 | 齐齐哈尔鹤翔制药有限责任公司 | Ointment for dispersing breast nodules and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 宣群: "莪术内生真菌产β-榄香烯代谢产物的研究", 《天然产物研究与开发》 * |
| 彭清忠: "内生菌对姜黄素的微生物转化", 《生物技术通讯》 * |
| 李标等: "内生真菌在中药现代化中的作用", 《中国中药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112791167A (en) * | 2021-01-12 | 2021-05-14 | 杭州青蜓遵序堂健康管理有限公司 | Preparation process of pain-relieving and stasis-removing hydrogel patch |
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Effective date of registration: 20240320 Address after: 161000, No.3 Nanjiao Road, Longsha District, Qiqihar City, Heilongjiang Province Patentee after: HEILONGJIANG HEXIANG PHARMACEUTICAL Co.,Ltd. Country or region after: Zhong Guo Patentee after: Zhou Jin Address before: 161005 No. 3, Nanjiao Road, Longsha District, Qiqihar City, Heilongjiang Province Patentee before: Zhou Jin Country or region before: Zhong Guo |