CN112754020A - Collagen tablet and preparation method thereof - Google Patents

Collagen tablet and preparation method thereof Download PDF

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Publication number
CN112754020A
CN112754020A CN202011615697.5A CN202011615697A CN112754020A CN 112754020 A CN112754020 A CN 112754020A CN 202011615697 A CN202011615697 A CN 202011615697A CN 112754020 A CN112754020 A CN 112754020A
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powder
collagen
sieving
vitamin
tablet
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秦强强
陈达永
陈丽琦
褚加冕
吴怀林
申张宇
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Taizhou Roosin Medical Product Co ltd
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Taizhou Roosin Medical Product Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/34—Sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/03—Organic compounds
    • A23L29/035—Organic compounds containing oxygen as heteroatom
    • A23L29/04—Fatty acids or derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention belongs to the technical field of health care products, and particularly relates to a collagen tablet and a preparation method thereof, wherein the collagen tablet comprises the following components in percentage by mass: 50-90% of collagen powder, 0-18% of milk powder, 0-10% of fruit and vegetable powder, 2-5% of magnesium stearate, 2-4% of vitamin, 0-8% of sweetening agent, 0-4% of edible essence, 3-10% of microcrystalline cellulose and 0-5% of powder adhesive. The collagen tablet comprises 50-90% of collagen powder, the content of the collagen powder is higher, the collagen tablet is prepared by adopting a tabletting mode, the collagen powder is furthest prevented from being damaged by other treatment forms, meanwhile, a proper amount of fruit and vegetable powder and vitamins are added, the absorption of the collagen is promoted, the sweetening agent and the edible essence can solve the problem of heavy fishy smell of the collagen powder, the taste is improved, the compressibility and the flowability of a mixed material can be improved by microcrystalline cellulose and magnesium stearate, and the tabletting rate is improved.

Description

Collagen tablet and preparation method thereof
Technical Field
The invention belongs to the technical field of health care products, and particularly relates to a collagen tablet and a preparation method thereof.
Background
Collagen is an important special protein in human body, and has triple anti-aging effects of supporting, repairing and protecting. The loss of collagen can accelerate the relaxation and aging of skin, and the skin is easy to have the phenomena of dark yellow, spot printing, dryness, large pores, roughness, wrinkles and the like. The collagen is an important method for effectively delaying the aging condition of the skin, increasing the content of the collagen in the human body is beneficial to restoring the plumpness and the elasticity of the skin, promoting the regeneration of skin tissues, having the functions of maintaining beauty and keeping young, and having good effects of preventing the skin from being loose and tightening the skin.
Chinese patent document CN103919143A discloses a roxburgh rose collagen tablet and a preparation method thereof, the roxburgh rose collagen tablet is a roxburgh rose collagen tablet nutritional food which is processed by using collagen powder, roxburgh rose freeze-dried powder, levorotatory vitamin C and grape seed extract as main raw materials, starch, sorbitol, mannitol, microcrystalline cellulose, stevioside and milk essence as secondary raw materials and magnesium stearate, and the roxburgh rose freeze-dried powder is fresh roxburgh rose pulp ZG-25 m2Processing by a freeze dryer, crushing by a KC-701 ultrafine crusher to obtain sterile roxburgh rose freeze-dried powder with fineness not less than 300 meshes and water content not higher than 8%, wherein the components in percentage by weight are as follows: 20-35% of collagen powder, 10-25% of roxburgh rose freeze-dried powder, 4-6% of levorotatory vitamin C, 0.3-0.5% of grape seed extract, 9-13% of starch, 8-12% of sorbitol, 8-12% of mannitol and 6-E of microcrystalline cellulose12 percent, 0.7 to 0.9 percent of stevioside, 0.3 to 0.5 percent of milk essence and 1.5 percent of magnesium stearate. Through developing a deep processing way of the roxburgh rose fruit, the problem that the original sour and astringent taste of the roxburgh rose fruit is unacceptable to consumers is solved, but the invention has the problem of low collagen content, and in addition, the roxburgh rose fruit is cool and is easy to cause gastrointestinal diseases after being eaten frequently.
Disclosure of Invention
In order to solve the problems, the invention discloses a collagen tablet and a preparation method thereof, the collagen tablet comprises 50-90% of collagen powder, the content of the collagen powder is higher, the collagen tablet is prepared by adopting a tablet pressing mode, the collagen powder is furthest ensured not to be damaged by other treatment forms, simultaneously, a proper amount of fruit and vegetable powder and vitamins are added, the absorption of the collagen is promoted, a sweetening agent and edible essence are also favorable, the problem of heavy fishy smell of the collagen powder is solved, the mouthfeel is improved, the compressibility and the fluidity of a mixed material can be improved by microcrystalline cellulose and magnesium stearate, and the tablet forming rate is favorably improved.
In order to achieve the purpose, the invention adopts the following technical scheme:
the collagen tablet comprises the following components in percentage by mass: 50-90% of collagen powder, 0-18% of milk powder, 0-10% of fruit and vegetable powder, 2-5% of magnesium stearate, 2-4% of vitamin, 0-8% of sweetening agent, 0-4% of edible essence, 2-10% of microcrystalline cellulose and 0-5% of powder adhesive.
Preferably, the collagen tablet comprises the following components in percentage by mass: 50-90% of collagen powder, 4-15% of milk powder, 2-10% of fruit and vegetable powder, 3-5% of magnesium stearate, 2-4% of vitamin, 1-5% of sweetening agent, 1-4% of edible essence, 2-8% of microcrystalline cellulose and 1-3% of powder adhesive.
Preferably, the milk powder is one or more of milk powder, goat milk powder, camel milk powder and soybean milk powder; the fruit and vegetable powder is one or more of apple powder, cherry powder, banana powder, willow orange powder, carrot powder, wax gourd powder and hawthorn powder.
Preferably, the fruit and vegetable powder is hawthorn powder or apple powder.
Preferably, the vitamin is one or more of vitamin A, vitamin C and vitamin E; the sweetener is one or more of xylitol, erythritol, crystalline fructose, isomaltose hypgather, aspartame and sucrose.
Preferably, the vitamin is vitamin C; the sweetener is xylitol.
Preferably, the powder binder is one or more of carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxymethyl cellulose and sodium hydroxymethyl cellulose.
A preparation method of a collagen tablet comprises the following steps:
(1) weighing the components in proportion, and premixing the vitamins, the sweetener and the edible essence in a mixer for 5-10min to obtain mixed powder I;
(2) adding collagen powder, milk powder, fruit and vegetable powder, microcrystalline cellulose and powder adhesive into a mixer, and mixing with the mixed powder I for 20-35min to obtain mixed powder II; adopting a wet granulation process, adding 40-80% ethanol water solution into the mixed powder II to obtain a material soft material, and sieving with a 25-35 mesh sieve to perform granulation operation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 45-60 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a sieve of 25-35 meshes for size stabilization, and sieving with a sieve of 60-80 meshes for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 10-18min to obtain the final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5-1.5 g/tablet, checking the tablet weight at intervals of 15-30min during tabletting, and controlling the deviation within +/-5% of the nominal value.
Preferably, the dosage ratio of the mixed powder II to the ethanol aqueous solution is 100g/8-12 mL;
the adding method of the ethanol water solution comprises the following steps: spraying ethanol water solution with a spray gun under continuous stirring to uniformly wet the powder until the powder is agglomerated by hand holding and dispersed by light touch.
Preferably, the dosage ratio of the mixed powder II to the ethanol aqueous solution is 100g/10-11 mL; the concentration of the ethanol water solution is 60-70%.
The invention has the following beneficial effects:
(1) the collagen tablet comprises 50-90% of collagen powder, the content of the collagen powder is higher, the collagen tablet is prepared by adopting a tabletting mode, the collagen powder is furthest ensured not to be damaged by other treatment forms, meanwhile, a proper amount of fruit and vegetable powder and vitamins are added, the absorption of the collagen is promoted, the sweetening agent and the edible essence can solve the problem of heavy fishy smell of the collagen powder, the taste is improved, the compressibility and the flowability of a mixed material can be increased by microcrystalline cellulose and magnesium stearate, and the tabletting rate is improved;
(2) the fruit and vegetable powder is preferably hawthorn powder or apple powder, so that better digestion and absorption of collagen can be facilitated, vitamin is preferably vitamin C, synthesis of collagen is facilitated, absorption and utilization of collagen by a human body are facilitated, xylitol is preferably selected as a sweetening agent, so that the taste can be improved, metabolism of xylitol in the human body is not regulated by insulin, and the fruit and vegetable powder is available for diabetics and has the function of preventing decayed teeth;
(3) the collagen tablet is added with the powder adhesive, so that the bonding force among the powder can be improved, better tabletting is facilitated, the condition that the tablet is cracked easily due to powder flying in the pressing process or after the compression molding is avoided, the tabletting rate is improved, and the waste is avoided;
(4) according to the invention, 40-80% ethanol water solution is adopted to treat powder in the tabletting process, then uniform particles with certain particle size are obtained through two-pass sieving, and then tabletting is carried out, the dosage ratio of the mixed powder II to the ethanol water solution is controlled to be 100g/8-12mL, and the dosage of the powder adhesive is controlled to be 1-3%, so that the granulating efficiency can be effectively improved, the repeated granulating operation of excessive powder is avoided, and the risk of powder pollution is reduced.
Detailed Description
The present invention will now be described in further detail with reference to examples.
Example 1
The collagen tablet comprises the following components in percentage by mass: 11% of bovine colostrum powder, 8% of apple powder, 5% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 3.5% of xylitol, 2% of edible essence, 1% of carboxymethyl cellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 5min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, apple powder, microcrystalline cellulose and carboxymethyl cellulose into a mixer, and mixing with the mixed powder I for 20min to obtain mixed powder II; adopting a wet granulation process, adding 70% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/8mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 50 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 10min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 1 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of a nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 2
The collagen tablet comprises the following components in percentage by mass: 8% of bovine colostrum powder, 6% of apple powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 3.5% of xylitol, 2% of edible essence, 1.2% of sodium carboxymethylcellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing the vitamin C, the xylitol and the edible essence in a mixer for 10min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, apple powder, microcrystalline cellulose and sodium carboxymethylcellulose into a mixer, and mixing with the mixed powder I for 30min to obtain mixed powder II; adopting a wet granulation process, adding 80% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/12mL), and sieving with a 30-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 30-mesh sieve for grading, and sieving with a 60-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 1.5 g/tablet, checking the tablet weight at intervals of 30min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 30-mesh sieve in the step (2) and sieving with a 60-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 3
The collagen tablet comprises the following components in percentage by mass: 10% of bovine colostrum powder, 3.5% of hawthorn powder, 4% of magnesium stearate, 2% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence, 2% of sodium carboxymethylcellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, fructus crataegi powder, microcrystalline cellulose and carboxymethylcellulose sodium into a mixer, and mixing with the mixed powder I for 35min to obtain mixed powder II; adopting a wet granulation process, adding 60% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/8mL), and sieving with a 35-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 35-mesh sieve for grading, and then sieving with an 80-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 18min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5 g/tablet, checking the tablet weight at intervals of 15min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 35-mesh sieve in the step (2) and sieving with a 80-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording the qualified rate.
Example 4
The collagen tablet comprises the following components in percentage by mass: 4.5% of goat milk powder, 3% of carrot powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence, 3% of hydroxymethyl cellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, goat milk powder, carrot powder, microcrystalline cellulose and hydroxymethyl cellulose into a mixer, and mixing with the mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 80% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/11mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 50 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 1 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of a nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 5
The collagen tablet comprises the following components in percentage by mass: 10% of soybean milk powder, 6% of hawthorn powder, 3% of magnesium stearate, 3% of vitamin E, 5% of microcrystalline cellulose, 3% of erythritol, 2% of edible essence, 2% of carboxymethyl cellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin E, erythritol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, soybean milk powder, fructus crataegi powder, microcrystalline cellulose and carboxymethyl cellulose into a mixer, and mixing with the mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 70% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/10mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 50 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 1 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of a nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 6
The collagen tablet comprises the following components in percentage by mass: 10% of bovine colostrum powder, 4% of hawthorn powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence, 2% of sodium carboxymethylcellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, fructus crataegi powder, microcrystalline cellulose and sodium carboxymethylcellulose into a mixer, and mixing with mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 70% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/10mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 7
The collagen tablet comprises the following components in percentage by mass: 10% of bovine colostrum powder, 4% of hawthorn powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, fructus crataegi powder, and microcrystalline cellulose into a mixer, and mixing with the mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 70% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/10mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 8
The collagen tablet comprises the following components in percentage by mass: 10% of bovine colostrum powder, 4% of hawthorn powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence, 2% of sodium carboxymethylcellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, fructus crataegi powder, microcrystalline cellulose and sodium carboxymethylcellulose into a mixer, and mixing with mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 40% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/10mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 9
The collagen tablet comprises the following components in percentage by mass: 10% of bovine colostrum powder, 4% of hawthorn powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence, 2% of sodium carboxymethylcellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, fructus crataegi powder, microcrystalline cellulose and sodium carboxymethylcellulose into a mixer, and mixing with mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 80% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/10mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 10
The collagen tablet comprises the following components in percentage by mass: 10% of bovine colostrum powder, 4% of hawthorn powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence, 0.5% of sodium carboxymethylcellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, fructus crataegi powder, microcrystalline cellulose and sodium carboxymethylcellulose into a mixer, and mixing with mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 70% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/10mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 11
The collagen tablet comprises the following components in percentage by mass: 10% of bovine colostrum powder, 4% of hawthorn powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence, 4% of sodium carboxymethylcellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, fructus crataegi powder, microcrystalline cellulose and sodium carboxymethylcellulose into a mixer, and mixing with mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 70% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/10mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 12
The collagen tablet comprises the following components in percentage by mass: 10% of bovine colostrum powder, 4% of hawthorn powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence, 2% of sodium carboxymethylcellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, fructus crataegi powder, microcrystalline cellulose and sodium carboxymethylcellulose into a mixer, and mixing with mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 70% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/8mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
Example 13
The collagen tablet comprises the following components in percentage by mass: 10% of bovine colostrum powder, 4% of hawthorn powder, 4% of magnesium stearate, 3% of vitamin C, 2.5% of microcrystalline cellulose, 2% of xylitol, 1% of edible essence, 2% of sodium carboxymethylcellulose and the balance of collagen powder.
The preparation method comprises the following steps:
(1) weighing the components in proportion, and premixing vitamin C, xylitol and edible essence in a mixer for 8min to obtain mixed powder I;
(2) adding collagen powder, bovine colostrum powder, fructus crataegi powder, microcrystalline cellulose and sodium carboxymethylcellulose into a mixer, and mixing with mixed powder I for 25min to obtain mixed powder II; adopting a wet granulation process, adding 70% ethanol water solution into the mixed powder II to obtain a soft material (the dosage ratio of the mixed powder II to the ethanol water solution is 100g/13mL), and sieving with a 25-mesh sieve for granulation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 55 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a 25-mesh sieve for grading, and sieving with a 70-mesh sieve for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 15min to obtain a final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5 g/tablet, checking the tablet weight at intervals of 20min in the tabletting process, and controlling the deviation within +/-5% of the nominal value.
And (3) after sieving with a 25-mesh sieve in the step (2) and sieving with a 70-mesh sieve in the step (3), respectively calculating the qualified rate according to the weight of the sieved particles and the non-sieved particles and recording.
The screening pass rates of the step (2) and the step (3) in each example and the pass rate of the collagen tablet prepared in each example were measured, and the results are shown in table 1.
TABLE 1 qualification Rate test results
Step (2) sieving percent of pass/%) Step (3) sieving percent of pass/%) Degree of friability Fall detection Disintegration time limit
Example 1 99.99 94.15 Qualified Qualified Qualified
Example 2 99.62 95.22 Qualified Qualified Qualified
Example 3 96.74 98.83 Qualified Qualified Qualified
Example 4 95.49 99.26 Qualified Qualified Qualified
Example 5 99.91 98.82 Qualified Qualified Qualified
Example 6 99.91 98.88 Qualified Qualified Qualified
Example 7 99.99 83.46 Fail to be qualified Fail to be qualified Qualified
Example 8 93.55 98.59 Qualified Qualified Qualified
Example 9 99.99 81.04 Qualified Qualified Qualified
Example 10 99.99 92.57 Qualified Fail to be qualified Qualified
Example 11 93.66 98.52 Qualified Qualified Fail to be qualified
Example 12 99.99 92.88 Qualified Qualified Qualified
Example 13 93.47 98.93 Fail to be qualified Fail to be qualified Qualified
Friability: testing by using a tablet friability instrument, blowing off the fallen powder by using a blower, precisely weighing, placing the powder in a cylinder of the tablet friability instrument to rotate for 100 times, taking out the powder, removing the powder by the same method, precisely weighing, reducing the weight loss by not more than 1%, and not detecting broken, cracked and crushed tablets, or else, not determining the weight loss; and (3) falling detection: freely dropping 5 tablets from the height of 1.5m, repeating each tablet for 2 to 3 times, wherein the tablet has no obvious fragment or fracture, which indicates that the hardness of the tablet is qualified, otherwise, the tablet is unqualified; checking disintegration time limit: and (4) checking the disintegration time limit of the tablet according to a disintegration time limit checking method of Chinese pharmacopoeia, and recording whether the disintegration time limit is qualified.
The sieving qualified rate of the step (2) in the embodiments 1 to 6 is more than 95%, the sieving qualified rate of the step (3) is more than 94%, the powder utilization rate is high, the repeated granulation operation of excessive powder can be avoided, and the risk of powder pollution is reduced. In addition, the collagen chips prepared in examples 1 to 6 were all acceptable in terms of friability, drop test and disintegration time.
Example 7 is different from example 6 only in that sodium carboxymethylcellulose is not added in example 7, and although the sieving yield in step (2) reaches 99.99%, the sieving yield in step (3) is only 83.46%, and many powders cannot smoothly enter the next step, and the friability of the prepared collagen chips is not satisfactory. Example 8 differs from example 6 only in that the concentration of the aqueous ethanol solution in example 8 is 40%, which results in less ethanol content being able to volatilize and more moisture being introduced into the powder, resulting in a lower sieving pass rate in step (2). Compared with example 6, the difference of example 9 is that the concentration of the ethanol aqueous solution in example 9 is 80%, which results in a high content of ethanol capable of being volatilized, and only a small amount of water can be introduced into the powder, which results in that the granulation requirement cannot be fully met, and although the sieving qualified rate in step (2) reaches 99.99%, the sieving qualified rate in step (3) is only 81.04%. Example 10 differs from example 6 only in that in example 10, the amount of sodium carboxymethylcellulose added was 0.5%, the content was small, resulting in poor granulation effect, the sieving pass rate in step (3) was 92.57%, the sieving pass rate was relatively low, and the small amount of sodium carboxymethylcellulose resulted in poor powder cohesion and failed drop test. Example 11 differs from example 6 only in that the amount of sodium carboxymethylcellulose added in example 11 is 4%, that an excessive amount of sodium carboxymethylcellulose results in a low sieving pass rate in step (2), and that an excessive binder content results in an unacceptable disintegration time limit test and a complete disintegration within a time period prescribed in the chinese pharmacopoeia. Example 12 compared with example 6, the difference is only that the amount ratio of the mixed powder II to the ethanol aqueous solution in example 12 is 100g/8mL, which results in more small-particle powder and lower sieving yield in step (3). Example 13 differs from example 6 only in that the amount ratio of the mixed powder II to the ethanol aqueous solution in example 13 was 100g/13mL, and the moisture content was large, resulting in a low sieving yield in step (1) and an unacceptable friability.
In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.

Claims (10)

1. A collagen sheet, which is characterized in that: the paint comprises the following components in percentage by mass: 50-90% of collagen powder, 0-18% of milk powder, 0-10% of fruit and vegetable powder, 2-5% of magnesium stearate, 2-4% of vitamin, 0-8% of sweetening agent, 0-4% of edible essence, 2-10% of microcrystalline cellulose and 0-5% of powder adhesive.
2. The collagen sheet according to claim 1, wherein: the paint comprises the following components in percentage by mass: 50-90% of collagen powder, 4-15% of milk powder, 2-10% of fruit and vegetable powder, 3-5% of magnesium stearate, 2-4% of vitamin, 1-5% of sweetening agent, 1-4% of edible essence, 2-8% of microcrystalline cellulose and 1-3% of powder adhesive.
3. The collagen sheet according to claim 1, wherein: the milk powder is one or more of milk powder, goat milk powder, camel milk powder and soybean milk powder; the fruit and vegetable powder is one or more of apple powder, cherry powder, banana powder, willow orange powder, carrot powder, wax gourd powder and hawthorn powder.
4. The collagen sheet according to claim 3, wherein: the fruit and vegetable powder is hawthorn powder or apple powder.
5. The collagen sheet according to claim 1, wherein: the vitamin is one or more of vitamin A, vitamin C and vitamin E; the sweetener is one or more of xylitol, erythritol, crystalline fructose, isomaltose hypgather, aspartame and sucrose.
6. The collagen sheet according to claim 5, wherein: the vitamin is vitamin C; the sweetener is xylitol.
7. The collagen sheet according to claim 1, wherein: the powder adhesive is one or more of carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxymethyl cellulose and sodium hydroxymethyl cellulose.
8. A method for preparing a collagen tablet according to any one of claims 1 to 7, wherein: the method comprises the following steps:
(1) weighing the components in proportion, and premixing the vitamins, the sweetener and the edible essence in a mixer for 5-10min to obtain mixed powder I;
(2) adding collagen powder, milk powder, fruit and vegetable powder, microcrystalline cellulose and powder adhesive into a mixer, and mixing with the mixed powder I for 20-35min to obtain mixed powder II; adopting a wet granulation process, adding 40-80% ethanol water solution into the mixed powder II to obtain a material soft material, and sieving with a 25-35 mesh sieve to perform granulation operation;
(3) putting the particles prepared in the step (2) into a vacuum drying oven, drying at 45-60 ℃ until the moisture content is lower than 3%, sieving the obtained dried particles with a sieve of 25-35 meshes for size stabilization, and sieving with a sieve of 60-80 meshes for removing fine particles to obtain particles with uniform size;
(4) putting the sized materials into a mixer, adding magnesium stearate, and mixing for 10-18min to obtain the final mixed material;
(5) tabletting with a rotary tablet machine according to the requirement of 0.5-1.5 g/tablet, checking the tablet weight at intervals of 15-30min during tabletting, and controlling the deviation within +/-5% of the nominal value.
9. The collagen sheet according to claim 8, wherein: the dosage ratio of the mixed powder II to the ethanol water solution is 100g/8-12 mL;
the adding method of the ethanol water solution comprises the following steps: spraying ethanol water solution with a spray gun under continuous stirring to uniformly wet the powder until the powder is agglomerated by hand holding and dispersed by light touch.
10. The collagen sheet according to claim 9, wherein: the dosage ratio of the mixed powder II to the ethanol water solution is 100g/10-11 mL; the concentration of the ethanol water solution is 60-70%.
CN202011615697.5A 2020-12-31 2020-12-31 Collagen tablet and preparation method thereof Pending CN112754020A (en)

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