CN103609994B - A kind of oral tablet containing Noni fruit composition and preparation method thereof - Google Patents
A kind of oral tablet containing Noni fruit composition and preparation method thereof Download PDFInfo
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- CN103609994B CN103609994B CN201310652034.4A CN201310652034A CN103609994B CN 103609994 B CN103609994 B CN 103609994B CN 201310652034 A CN201310652034 A CN 201310652034A CN 103609994 B CN103609994 B CN 103609994B
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- 244000131360 Morinda citrifolia Species 0.000 title claims abstract description 64
- 235000017524 noni Nutrition 0.000 title claims abstract description 64
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 58
- 239000007935 oral tablet Substances 0.000 title claims abstract description 57
- 229940096978 oral tablet Drugs 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 240000007817 Olea europaea Species 0.000 claims abstract description 35
- 239000000843 powder Substances 0.000 claims description 39
- 239000003826 tablet Substances 0.000 claims description 20
- 239000002994 raw material Substances 0.000 claims description 19
- 238000001035 drying Methods 0.000 claims description 18
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 10
- 235000008898 Morinda citrifolia Nutrition 0.000 claims description 9
- 238000005550 wet granulation Methods 0.000 claims description 9
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 6
- 229920002774 Maltodextrin Polymers 0.000 claims description 6
- 239000005913 Maltodextrin Substances 0.000 claims description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- 229940035034 maltodextrin Drugs 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000000377 silicon dioxide Substances 0.000 claims description 6
- 239000000811 xylitol Substances 0.000 claims description 6
- 235000010447 xylitol Nutrition 0.000 claims description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 239000000796 flavoring agent Substances 0.000 abstract description 4
- 235000019634 flavors Nutrition 0.000 abstract description 4
- 210000002784 stomach Anatomy 0.000 abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000011122 softwood Substances 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 201000006549 dyspepsia Diseases 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000004880 explosion Methods 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000001291 vacuum drying Methods 0.000 description 3
- 235000020985 whole grains Nutrition 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 229940046011 buccal tablet Drugs 0.000 description 2
- 239000006189 buccal tablet Substances 0.000 description 2
- 239000007910 chewable tablet Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 235000021022 fresh fruits Nutrition 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000123069 Ocyurus chrysurus Species 0.000 description 1
- 235000002725 Olea europaea Nutrition 0.000 description 1
- 241000207834 Oleaceae Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- -1 hyoscines Natural products 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of oral tablet containing Noni fruit composition, wherein, this oral tablet contains Noni fruit and olive, and wherein, with the gross weight benchmark of oral tablet, the consumption of Noni fruit is 10-70 % by weight, and the consumption of olive is 10-50% % by weight.The invention also discloses a kind of preparation method of oral tablet, wherein, described oral tablet is the oral tablet containing Noni fruit composition provided by the present invention.Oral tablet taste flavor provided by the present invention is good, has the effect regulating stomach and improving water flood.
Description
Technical field
The present invention relates to a kind of oral tablet containing Noni fruit composition and preparation method thereof.
Background technology
Noni fruit (Noni) is that being commonly called as of Morinda Citrifolia has another name called beach wood bar halberd.It is the fruit of the tropical evergreen perennial evergreen arbor war proclamation setting forth the purpose of the expedition and enumerating the crimes of the enemy tree originating in island, the South Pacific Ocean.Noni fruit is called as " super fruit ", be rich in 227 kinds of nutritional labelings, comprising 13 kinds of vitamin (A, B, C, E etc.), 16 kinds of mineral matter (potassium, sodium, zinc, calcium, iron, magnesium, phosphorus, copper, selenium etc.), 8 kinds of trace elements, also comprise 20 several amino acids (being superpower combinations maximum containing amino acid classes in plant) of 9 kinds of human body institute essential amino acids, kind more than 10 has the material of antioxidation, also containing multiple alkaloids such as hyoscines, polysaccharides, multiple ferment etc. have the composition of medical value, it is very potent natural comprehensive vitamin.Through research find promise beautiful have regulate the stomach of human body, digestive system, antioxidation, can effective scavenging free radicals higher than many antioxidants, enhancing function of immune system.
That sells in the market has Morinda Citrifolia juice, Noni health-care wine, the beautiful oral tablet of promise etc. containing the product of Noni fruit active ingredient, but has strong stink, so the mouthfeel of the beautiful oral tablet of existing promise is generally poor due to the Noni fruit of maturation.
Summary of the invention
The object of the invention is to the above-mentioned defect overcoming the existence of existing promise beautiful oral tablet, provide a kind of taste flavor good, there is the beautiful oral tablet of promise of good adjustment stomach and improving water flood effect.
Another object of the present invention is also the preparation method providing the beautiful oral tablet of promise of the present invention.
The invention provides a kind of oral tablet containing Noni fruit composition, wherein, this oral tablet contains Noni fruit and olive, and wherein, with the gross weight benchmark of oral tablet, the consumption of Noni fruit is 10-70 % by weight, and the consumption of olive is 10-50% % by weight.
Present invention also offers a kind of preparation method of oral tablet, wherein, described oral tablet is the oral tablet containing Noni fruit composition provided by the present invention.
Oral tablet taste flavor containing Noni fruit composition provided by the invention is good, has good adjustment stomach and effect of improving water flood.
Other features and advantages of the present invention are described in detail in detailed description of the invention part subsequently.
Detailed description of the invention
The invention provides many applicable creative concepts, this creative concept can be reflected in a large number of in concrete context.The specific embodiment described in following embodiments of the present invention only as the exemplary illustration of specific implementation of the present invention, and does not form limitation of the scope of the invention.
The invention provides a kind of oral tablet containing Noni fruit composition, wherein, this oral tablet contains Noni fruit and olive, and wherein, with the gross weight benchmark of oral tablet, the consumption of Noni fruit is 10-70 % by weight, and the consumption of olive is 10-50% % by weight.
In preferred situation, with the gross weight benchmark of oral tablet, the consumption of Noni fruit is 15-65 % by weight, and the consumption of olive is 15-45 % by weight.
Wherein:
Nuo Li is the fruit of madder wort war proclamation setting forth the purpose of the expedition and enumerating the crimes of the enemy tree (Morinda Citrifolia);
Olive is the fruit of Oleaceae plants olive (Olea europaea).
In the present invention, described olive is preferably Chinese yunnan and economizes the Yunnan olive produced.
Oral tablet provided by the present invention is also containing auxiliary material, and described auxiliary material can prepare the conventional adjunct ingredient of tablet for this area, such as sweetener, thickener, adhesive, filler, disintegrant, lubricant, wetting agent etc.Wherein, with the gross weight of described oral tablet for benchmark, the total content of described auxiliary material is 40-70 % by weight.
Under preferable case, described auxiliary material comprises xylitol, maltodextrin, natrium citricum, edible salt, silica and dolomol.Wherein, with the gross weight of oral tablet for benchmark, the consumption of xylitol is 10-45% weight portion, the consumption of maltodextrin is 5-10% weight portion, the consumption of natrium citricum is 0.1-5% weight portion, the consumption of salt is 0.05-5% weight portion, the consumption of silica is 0.5-10% weight portion, the consumption of dolomol is 0.5-5% weight portion.Wherein, xylitol and maltodextrin use as filler, have simultaneously and strengthen the sweet cool effect of mouthfeel; Citric acid and salt use as flavor enhancement; Silica, dolomol use as lubricant.
In oral tablet provided by the present invention, described Noni fruit and olive can be powder type, and for the ease of the absorption of active ingredient and the mouthfeel of oral tablet, the particle mean size of Noni fruit and olive is preferably 120-10000 order.When described oral tablet granularity is lower than 500 order, being ordinary powder, is ultra-micro powder when the granularity of described oral tablet is 500-10000 order.In order to obtain better mouthfeel, the powder manufacturing oral tablet provided by the present invention is preferably ultra-micro powder.
Oral tablet provided by the present invention can be buccal tablet or chewable tablets.
In oral tablet provided by the present invention, can also containing the additive for regulating tablet taste, such as flavoring essence etc.
Present invention also offers a kind of preparation method of oral tablet, wherein, described oral tablet is the oral tablet containing the beautiful composition of promise provided by the present invention.
Wherein, in the present invention, the olive used can commercially buy the product cooked, also can be undertaken by conventional concocting method brewed after olive powder, such as can by the finished product of spraying dry acquisition after olive fresh fruit raw material is squeezed the juice.The particle mean size of the emblica powder obtained is preferably 120-10000 order, is more preferably 200-6000 order.
Wherein, in the present invention, the Noni fruit raw material used also can be able to be fresh Noni fruit raw material for dry Noni fruit raw material.
In the present invention, when described Noni fruit raw material is dry Noni fruit raw material, the preparation method of described oral tablet can comprise the following steps: (1) is carried out pulverizing after the Noni fruit powder of drying and olive powder being mixed in proportion respectively and crossed 120-10000 mesh sieve acquisition mixing fine powders end; (2) with wet granulation method, described mixing fine powders end is pressed into tablet.
Wherein, in step (1), the Noni fruit powder of described drying can comprise to be done by Noni fruit or Noni fruit powder that Noni fruit dry plate is made, the present invention does have no particular limits with the mode of Noni fruit dry plate for preparing Noni fruit, drying can be carried out by the drying means of this area routine, if can obtain water content lower than 10% % by weight raw material, under preferable case, in order to reduce the loss of Noni fruit active ingredient, preferably under not higher than the condition of 70 DEG C, carry out drying.
Wherein, in step (2), the condition for wet granulation has no particular limits, and can carry out according to the condition of this area routine, and such as, described wet granulation method can comprise the following steps:
A) softwood processed, adds in mixing fine powders end by the ethanolic solution of 90 % by weight ~ 95 % by weight, and limit bevelling stirs, until mix.Softwood requirement clenching of the hand can be agglomerating and tack-free, splits for degree with the light pressure energy of finger.Ethanol consumption can be determined according to the humidity of softwood when granulating, if softwood is partially dry, should not particle be made, can suitably increase, if softwood is partially wet, incorporation time is long, and pellet hardness is large, affects tablet quality, can suitably reduce, in preferred situation, relative to mixing fine powders end described in 1000g, the addition of described ethanol is 350-450ml.
B) wet granular processed, sieved with 20 eye mesh screens by the softwood that step a) obtains, wet granular processed, can connect grain with stainless steel disc under screen cloth, and laying should not be too thick, and granulosa thickness is about 15-25mm; After obtaining wet granular with wet granulation method, the wet granular prepared can be sent into vacuum drying chamber or the hot air circulation drying oven inner drying with explosion prevention function, baking temperature 50 DEG C ~ 70 DEG C, drying time all with till parching, is preferably 6h ~ 8h with particle; Machine compressing tablet is used after obtaining the whole grain that dried particles 120 eye mesh screens can be sieved after dried particles.
Tablet provided by the present invention can be buccal tablet or chewable tablets.
The tablet weight variation of tablet provided by the present invention is preferably 0.70g+5% (standards of pharmacopoeia), and namely the weight of every sheet is preferably 0.665g ~ 0.735g.
The preparation method of tablet provided by the present invention also comprises packaging step and the sterilization steps after packing.
The mode of irradiation sterilization can be adopted in the present invention to carry out packing rear sterilizing, and irradiation sterilization dosage is preferably 6 ~ 10KGY.
In the present invention, when described Noni fruit raw material is fresh Noni fruit, the preparation method of described oral tablet can comprise the following steps: fresh Noni fruit is squeezed the juice and filtered removal and is greater than 40-500 object residue acquisition Morinda Citrifolia juice by (1);
(2) at 4-80 DEG C, described Morinda Citrifolia juice is mixed in proportion with 40-10000 object olive powder and auxiliary material and obtain raw material mixed liquor;
(3) described raw material mixed liquor is dried at 50-70 DEG C the raw mixture obtaining drying, then the raw mixture of described drying is pulverized as 120-10000 object dried powder;
(4) by wet granulation method, described dried powder is pressed into tablet.
Wherein, step (4) can adopt and prepare the identical method of oral tablet with the Noni fruit raw material above by drying and carry out.
In more detail the present invention is described below by embodiment.
The processing method of raw material used in following examples is as follows.
Respectively by Noni fruit slice lapping to the 120 object powder of drying.
By fresh Yunnan olive fruits (green-yellow, fresh, without rotting, free from admixture) pulverize and squeeze the juice, then spend acquisition 5000 object olive powder with spray drying process at 50 DEG C.
Below will be described the present invention by embodiment.
Embodiment 1-5
Embodiment 1-5 prepares the method for oral tablet for illustration of dry Noni fruit raw material provided by the invention.
Carry out second time after Noni fruit raw material and auxiliary material being mixed respectively according to the proportioning mode listed by table 1 pulverize and cross 5000 mesh sieves acquisition mixing fine powders ends; Wet granulation is carried out after being mixed with olive powder at mixing fine powders end, 95% ethanol of 400ml is added in mixing fine powders end, limit bevelling stirs, until mix, then softwood 20 eye mesh screens are sieved, wet granular processed, connects grain with stainless steel disc under screen cloth, and granulosa thickness is about 20mm and obtains wet granular; The wet granular prepared is sent into the vacuum drying chamber inner drying with explosion prevention function, baking temperature 60 DEG C, dry 7h obtains dried particles; Sieved after whole grain with 40 eye mesh screens by dried particles and carry out compressing tablet, obtain the tablet 1-5 of 1g, carry out irradiation sterilization after tablet packaging, irradiation dose is 10KGY.
Embodiment 6
The present embodiment is for illustration of the method preparing oral tablet with fresh Noni fruit raw material provided by the invention.
Beautiful for promise fresh fruit is squeezed the juice and filters removal and be greater than 500 object residues acquisition Morinda Citrifolia juice; At 50 DEG C, Morinda Citrifolia juice and 5000 object olive powder and auxiliary material are mixed in ratio listed in table 1 and obtain raw material mixed liquor; Raw material mixed liquor is dried at 60 DEG C and obtains dry raw mixture, pulverized by the raw mixture of drying is carry out wet granulation after 5000 object dried powders again, 95% ethanol of 400ml is added in mixing fine powders end, limit bevelling stirs, until mix, then softwood 20 eye mesh screens are sieved, wet granular processed, connect grain with stainless steel disc under screen cloth, granulosa thickness is about 20mm and obtains wet granular; The wet granular prepared is sent into the vacuum drying chamber inner drying with explosion prevention function, baking temperature 60 DEG C, dry 7h obtains dried particles; Sieved after whole grain with 5000 eye mesh screens by dried particles and carry out compressing tablet, obtain the tablet 6 of 1g, carry out irradiation sterilization after tablet packaging, irradiation dose is 10KGY.
Table 1
| Embodiment | 1 | 2 | 3 | 4 | 5 | 6 |
| Nuo Li (% by weight) | 35 | 15 | 45 | 10 | 70 | 35 |
| Olive (% by weight) | 20 | 45 | 15 | 50 | 10 | 20 |
| Xylitol (% by weight) | 35 | 32 | 30 | 30 | 12 | 35 |
| Maltodextrin (% by weight) | 6 | 5 | 7 | 5 | 5 | 6 |
| Natrium citricum (% by weight) | 0.3 | 0.1 | 0.1 | 0.1 | 0.1 | 0.3 |
| Salt (% by weight) | 1 | 0.1 | 0.1 | 0.1 | 0.1 | 1 |
| Silica (% by weight) | 2 | 0.8 | 0.8 | 1.8 | 2 | 2 |
| Dolomol (% by weight) | 0.7 | 2 | 2 | 3 | 0.8 | 0.7 |
Test case 1-6
Test case 1-6 is for illustration of the effect of oral tablet provided by the invention.
(1) to the improvement of indigestion symptom
Select 300 men and women patients with indigestion symptom in various degree, age of patient 35-70 year between, be divided into 6 groups (often organizing 50 patients) at random.Take tablet 1-6 respectively, instructions of taking is sooner or later respectively take 1 time, each 1 every day, 3 weeks observing effects after taking, and compared with before taking, what symptom disappeared completely is labeled as zero, and what symptom obviously alleviated is labeled as △, what symptom was not improved be labeled as ×; The result for the treatment of of 6 groups is as shown in table 2.
Table 2
(2) insomnia improves
Select 300 men and women patients with indigestion symptom in various degree, age of patient 35-70 year between, be divided into 6 groups (often organizing 50 patients) at random.Take tablet 1-6 respectively, instructions of taking is sooner or later respectively take 1 time, each 1 every day, 3 weeks observing effects after taking, and compared with before taking, what symptom disappeared completely is labeled as zero, and what symptom obviously alleviated is labeled as △, what symptom was not improved be labeled as ×; The result for the treatment of of 6 groups is as shown in table 3.
Table 3
As can be seen from the test result of above test case, Chinese medicine composition provided by the invention can effectively improve indigestion, insomnia.
It should be noted, the present invention will be described instead of limit the invention for above-described embodiment, and those skilled in the art can design alternative embodiment when not departing from claims scope.In the claims, any reference symbol between bracket should be configured to limitations on claims.Word " comprises " not to be got rid of existence and does not arrange element in the claims or step.
Claims (8)
1. the oral tablet containing Noni fruit composition, it is characterized in that, this oral tablet contains Noni fruit and olive, wherein, with the gross weight benchmark of oral tablet, the consumption of Noni fruit is 10-70 % by weight, the consumption of olive is 10-50 % by weight, and described oral tablet also contains auxiliary material, with the gross weight of described oral tablet for benchmark, the total content of described auxiliary material is 20-70 % by weight, and described auxiliary material comprises xylitol, maltodextrin, natrium citricum, edible salt, silica and dolomol.
2. oral tablet according to claim 1, wherein, with the gross weight benchmark of oral tablet, the consumption of Noni fruit is 15-65 % by weight, and the consumption of olive is 15-45 % by weight.
3. oral tablet according to claim 1, wherein, with the gross weight of oral tablet for benchmark, the consumption of xylitol is 10-45 % by weight, the consumption of maltodextrin is 5-10 % by weight, the consumption of natrium citricum is 0.1-5 % by weight, the consumption of edible salt is 0.05-5 % by weight, the consumption of silica is 0.5-10 % by weight, the consumption of dolomol is 0.5-5 % by weight.
4. oral tablet according to claim 1 and 2, wherein, described Noni fruit and olive are powder, and the particle mean size of Noni fruit powder is 120-10000 order, and the particle mean size of olive powder is 120-10000 order.
5. a preparation method for the oral tablet containing Noni fruit composition as claimed in claim 4, the method comprises the following steps: (1) is carried out pulverizing after the Noni fruit powder of drying and olive powder being mixed in proportion respectively and crossed 120-10000 mesh sieve acquisition mixing fine powders end; (2) with wet granulation method, described mixing fine powders end is pressed into tablet.
6. preparation method according to claim 5, wherein, described olive powder is the spraying dry finished product of olive juice, and particle diameter is 120-10000 order.
7. a preparation method for the oral tablet containing Noni fruit composition as claimed in claim 4, the method comprises the following steps: fresh Noni fruit is squeezed the juice and filtered removal and is greater than 40 object residues acquisition Morinda Citrifolia juice by (1); (2) at 4-80 DEG C, described Morinda Citrifolia juice is mixed in proportion with 120-10000 object olive powder and auxiliary material and obtain raw material mixed liquor; (3) described raw material mixed liquor is dried at 50-70 DEG C the raw mixture obtaining drying, then the raw mixture of described drying is pulverized as 120-10000 object dried powder; (4) by wet granulation method, described dried powder is pressed into tablet.
8. preparation method according to claim 7, wherein, described olive powder is the spraying dry finished product of olive juice, and particle diameter is 120-10000 order.
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| CN104856049A (en) * | 2015-06-19 | 2015-08-26 | 孟鸿龙 | Natural composite nutrient tablet |
| CN108175086A (en) * | 2017-12-25 | 2018-06-19 | 广州美耕食品有限公司 | A kind of Noni fruit eucommia Bark male flower comprehensive enzyme piece |
| CN109349642A (en) * | 2018-12-26 | 2019-02-19 | 陕西天承生物科技股份有限公司 | A kind of folium cortex eucommiae compound buccal lozenge and preparation method thereof improved the immunity of the human body |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101062101A (en) * | 2007-06-01 | 2007-10-31 | 郑金营 | Material formula of olive fruit buccal tablet and the preparing method thereof |
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| CN101062101A (en) * | 2007-06-01 | 2007-10-31 | 郑金营 | Material formula of olive fruit buccal tablet and the preparing method thereof |
Non-Patent Citations (2)
| Title |
|---|
| Study of coating tablet extract noni fruit (Morinda citrifolia, L.) with maltodextrin as a subcoating material;Effionora Anwar等;《J MED SCI》;20071231;第7卷(第5期);第762-768 * |
| 西双版纳伊甸园热带作物科技有限公司.Q/YZ002S-2013 诺丽果片(压片糖果).《Q/YZ002S-2013 诺丽果片(压片糖果)》.2013,第1-6页. * |
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