CN112741883B - Ginseng and poria cocos traditional Chinese medicine composition for tonifying spleen and nourishing blood and preparation method thereof - Google Patents
Ginseng and poria cocos traditional Chinese medicine composition for tonifying spleen and nourishing blood and preparation method thereof Download PDFInfo
- Publication number
- CN112741883B CN112741883B CN202110172129.0A CN202110172129A CN112741883B CN 112741883 B CN112741883 B CN 112741883B CN 202110172129 A CN202110172129 A CN 202110172129A CN 112741883 B CN112741883 B CN 112741883B
- Authority
- CN
- China
- Prior art keywords
- blood
- spleen
- fine powder
- ginseng
- poria cocos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 62
- 239000008280 blood Substances 0.000 title claims abstract description 53
- 235000003140 Panax quinquefolius Nutrition 0.000 title claims abstract description 52
- 210000004369 blood Anatomy 0.000 title claims abstract description 52
- 210000000952 spleen Anatomy 0.000 title claims abstract description 36
- 244000197580 Poria cocos Species 0.000 title claims abstract description 33
- 235000008599 Poria cocos Nutrition 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 title claims description 11
- 235000008434 ginseng Nutrition 0.000 title claims description 11
- 241000208340 Araliaceae Species 0.000 title 1
- 240000005373 Panax quinquefolius Species 0.000 claims abstract description 51
- 239000008187 granular material Substances 0.000 claims abstract description 40
- 230000000694 effects Effects 0.000 claims abstract description 33
- 241000132012 Atractylodes Species 0.000 claims abstract description 23
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 23
- 235000008422 Schisandra chinensis Nutrition 0.000 claims abstract description 23
- 235000006533 astragalus Nutrition 0.000 claims abstract description 23
- 241000382455 Angelica sinensis Species 0.000 claims abstract description 22
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 206010043554 thrombocytopenia Diseases 0.000 claims abstract description 16
- 230000000740 bleeding effect Effects 0.000 claims abstract description 15
- 230000007812 deficiency Effects 0.000 claims abstract description 13
- 239000002775 capsule Substances 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims description 108
- 238000002156 mixing Methods 0.000 claims description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 58
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 238000001035 drying Methods 0.000 claims description 36
- 239000000284 extract Substances 0.000 claims description 36
- 229940079593 drug Drugs 0.000 claims description 31
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 22
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 18
- 229930006000 Sucrose Natural products 0.000 claims description 18
- 239000000706 filtrate Substances 0.000 claims description 18
- 238000001914 filtration Methods 0.000 claims description 18
- 238000007873 sieving Methods 0.000 claims description 18
- 239000005720 sucrose Substances 0.000 claims description 18
- 229920001353 Dextrin Polymers 0.000 claims description 12
- 239000004375 Dextrin Substances 0.000 claims description 12
- 235000019425 dextrin Nutrition 0.000 claims description 12
- 241000737241 Cocos Species 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 241000125175 Angelica Species 0.000 claims description 3
- 241001061264 Astragalus Species 0.000 claims description 3
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 3
- 210000004233 talus Anatomy 0.000 claims description 3
- 239000009636 Huang Qi Substances 0.000 claims description 2
- 241001313857 Bletilla striata Species 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 abstract description 14
- 238000005728 strengthening Methods 0.000 abstract description 9
- 244000170916 Paeonia officinalis Species 0.000 abstract description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract description 2
- 239000003826 tablet Substances 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 20
- 208000032843 Hemorrhage Diseases 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 7
- 238000012449 Kunming mouse Methods 0.000 description 6
- 210000001772 blood platelet Anatomy 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 229960004397 cyclophosphamide Drugs 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 3
- 108010054147 Hemoglobins Proteins 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000008551 shenshao Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 244000307697 Agrimonia eupatoria Species 0.000 description 1
- 241001127714 Amomum Species 0.000 description 1
- 244000141331 Amomum villosum Species 0.000 description 1
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 240000007371 Cuscuta campestris Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000123589 Dipsacus Species 0.000 description 1
- 241000893536 Epimedium Species 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 244000131360 Morinda citrifolia Species 0.000 description 1
- 235000008898 Morinda citrifolia Nutrition 0.000 description 1
- 235000008248 Morinda citrifolia var citrifolia Nutrition 0.000 description 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 206010033661 Pancytopenia Diseases 0.000 description 1
- 206010037549 Purpura Diseases 0.000 description 1
- 241001672981 Purpura Species 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 208000032140 Sleepiness Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 235000000125 common agrimony Nutrition 0.000 description 1
- 229940108605 cyclophosphamide injection Drugs 0.000 description 1
- 208000024389 cytopenia Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000018905 epimedium Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000017524 noni Nutrition 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000037321 sleepiness Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a Chinese medicinal composition for strengthening spleen and nourishing blood and a preparation method thereof, wherein the Chinese medicinal composition is prepared from eleven raw material medicaments, namely American ginseng, dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, white paeony root, schisandra chinensis and rhizoma bletillae, and is processed into granules, capsules and tablets. The invention has the effects of invigorating qi, strengthening spleen, nourishing blood and stopping bleeding. Can be used for treating thrombocytopenia due to weakness of spleen and stomach and deficiency of both qi and blood.
Description
Technical Field
The invention relates to a ginseng-poria cocos spleen-tonifying and blood-nourishing traditional Chinese medicine composition and a preparation method thereof, and belongs to the technical field of pharmacy.
Background
Thrombocytopenia caused by weakness of spleen and stomach and deficiency of both qi and blood belongs to a common and frequent disease in clinic, and common symptoms are intolerance of cold, soreness and weakness of waist, dark complexion or chest distress and hypochondriac pain. Seriously affecting the health of people. Chinese patent gazette 2018, 9, 4 and discloses a patent application with the name 'Shenshao Yiqi-tonifying and blood-nourishing granule Chinese medicinal composition and a preparation method thereof' published with the name of CN108478745A, which is applied by the applicant, wherein the raw material medicaments consist of 12 Chinese medicinal materials of red ginseng, white paeony root, astragalus, prepared rehmannia root, Chinese angelica, epimedium herb, medicinal indianmulberry root, himalayan teasel root, south dodder seed, hairyvein agrimony, fried largehead atractylodes rhizome and villous amomum fruit, and have the effects of tonifying qi, promoting the production of body fluid, strengthening marrow, generating blood, tonifying yang, tonifying kidney, tonifying spleen and invigorating stomach; can be used for treating aplastic anemia, myelodysplastic syndrome, thrombocytopenia and cytopenia caused by radiotherapy and chemotherapy, with the symptoms of deficiency of both qi and blood and insufficiency of kidney-yang. The inventor has made a great deal of research on the technology in recent years and finds that the curative effect on the thrombocytopenia caused by weakness of spleen and stomach and deficiency of both qi and blood is not ideal, so that the traditional Chinese medicine composition for treating the thrombocytopenia caused by weakness of spleen and stomach and deficiency of both qi and blood, which is prepared from Chinese herbal medicines, has better curative effect, reasonable compatibility, synergistic effect, clear effect, safety and no toxic or side effect, has wide application prospect and market space.
Disclosure of Invention
The invention aims to provide a ginseng-poria cocos spleen-invigorating and blood-nourishing traditional Chinese medicine composition and a preparation method thereof.
The ginseng-poria cocos traditional Chinese medicine composition for tonifying spleen and nourishing blood disclosed by the invention has the following effects: the invention has the effects of invigorating qi, strengthening spleen, nourishing blood and stopping bleeding. Can be used for treating thrombocytopenia due to weakness of spleen and stomach and deficiency of both qi and blood.
The invention provides a ginseng-poria cocos spleen-tonifying and blood-nourishing traditional Chinese medicine composition which is characterized by being prepared from the following raw material medicines:
american ginseng, dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus membranaceus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae.
The invention provides a ginseng-poria spleen-invigorating and blood-nourishing traditional Chinese medicine composition which is characterized by being prepared from the following raw material medicines in parts by weight:
the spleen-invigorating and blood-nourishing traditional Chinese medicine composition is characterized by being prepared from the following raw material medicines in a preferable weight ratio:
according to the ginseng-poria spleen-invigorating and blood-nourishing traditional Chinese medicine composition, the preparation method of the granules comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, making into 1000g granule, and packaging to obtain granule.
According to the ginseng and poria cocos traditional Chinese medicine composition for tonifying spleen and nourishing blood, the preparation method of the capsule comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, and making into capsule of 1000 granules.
According to the ginseng-poria spleen-invigorating and blood-nourishing traditional Chinese medicine composition, the preparation method of the tablet comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, starch and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, tabletting, and making into 1000 tablets to obtain tablet.
The invention has the advantages that: the Chinese herbal medicines are used as raw materials, so that the traditional Chinese medicine composition has the advantages of better curative effect, reasonable compatibility, synergistic effect, clear effect, safety and no toxic or side effect.
The invention has the beneficial effects that:
the prescription is a clinical protocol prescription used for a long time by a hospital affiliated to the department of research on controlling blood diseases in Shanxi province, and the curative effect is fully determined by doctors and patients. The book of medical records is recorded: the spleen and stomach are the acquired origin and the source of qi and blood generation. The prescription is mainly used for treating thrombocytopenia caused by insufficient blood and blood generation due to spleen and stomach injury caused by overeating. Clinically, the complexion is withered and white, sleepiness and hypodynamia, low voice and purpura are easy to occur. The prescription examination of medicine (R) is as follows: "spleen deficiency failing to promote the appetite and leading to a reduction in food and drink, it is advisable to replenish qi and invigorate the spleen". Therefore, American ginseng is sweet and cold in flavor, and is used as a monarch drug for tonifying spleen and stomach, nourishing yin, clearing fire and promoting fluid production. The spleen is the yin earth, prefers dryness and dislike of dampness, and the dried orange peel is bitter, pungent and warm, regulates qi, strengthens the spleen, eliminates dampness and reduces phlegm; bighead atractylodes rhizome, being bitter and warm, has the effects of tonifying qi and strengthening spleen, eliminating dampness and promoting diuresis, and stopping sweating; poria cocos, sweet and bland, strengthens the spleen and excretes dampness; rhizoma atractylodis is pungent and bitter, and has the effects of strengthening spleen, eliminating dampness and activating spleen; sha ren is pungent and warm in property, resolving dampness and moving qi. The five medicines are combined, so that the effects of invigorating spleen and promoting diuresis are great, the transportation and transformation of the spleen and the stomach are enhanced, the source of qi and blood generation is restored, and the qi and blood are vigorous and are used as ministerial medicines. Astragalus root, radix astragali is sweet and warm, has the effects of invigorating qi and raising yang, benefiting wei and securing exterior, inducing diuresis to alleviate edema, and is used as the commander of blood immediately; angelica is sweet and warm in nature, can enrich blood and promote blood circulation, radix paeoniae alba is bitter and sour, can nourish blood and astringe yin, is used as the mother of qi, schisandra chinensis is sour and sweet in nature, can astringe vital essence, can nourish five internal organs to ensure that qi and blood can not be biochemically generated and live, and can make the source of body fluid and blood continuous; has the efficacy of benefiting qi and nourishing blood together and is an adjuvant drug. Bai Ji is bitter, sweet and astringent, cold in nature, astringes to stop bleeding, treats the disease at the present stage, and stops the disease at the first opportunity, thus being used as a guiding drug. Make qi and blood recover as usual naturally, and make the disease disappear. The whole formula is reviewed, and the main effects of tonifying qi and spleen, nourishing blood and stopping bleeding are achieved. Can be used for treating thrombocytopenia due to weakness of spleen and stomach and deficiency of both qi and blood. The formula has definite curative effect, small side effect and high safety, and is more suitable for long-term administration of patients. The invention adopts modern pharmaceutical technology, has stable quality and convenient administration. The product is safe and effective, can be taken for a long time, and is an ideal medicine for patients with thrombocytopenia caused by weakness of spleen and stomach and deficiency of both qi and blood.
By searching Chinese patent and literature databases, patents and research literatures which are the same as or similar to the formula of the invention are not found, the formula of the invention has innovative design theory and thought, and the Chinese patent medicine for treating thrombocytopenia caused by weakness of spleen and stomach and deficiency of both qi and blood is developed on the basis of the formula of the invention, so that the market demand prospect is wide.
The main pharmacodynamic tests are as follows
The ginseng-poria cocos traditional Chinese medicine composition for tonifying spleen and nourishing blood is compared with the prior art
Purpose of the experiment: through pharmacological experimental study on the effects of the ginseng-poria spleen-strengthening and blood-nourishing traditional Chinese medicine composition on blood enriching and nourishing, platelet increasing, bleeding stopping and the like in the prior art CN108478745A, the ginseng-poria spleen-strengthening and blood-nourishing granules are compared with the prior art CN108478745A, and the strength of the pharmacological effect is observed.
Drugs for testing:
1. a group: the traditional Chinese medicine composition is prepared by the method of example 1 in the specific implementation mode of 'a traditional Chinese medicine composition of Shenshao Yiqi tonifying and blood nourishing granule and a preparation method thereof' which is disclosed by Chinese patent publication No. CN108478745A in 9, 4 and 2018.
2. The ginseng and poria cocos spleen-tonifying and nourishing granule group comprises the following components: prepared according to the formula and the preparation method of the embodiment 1 of the specification.
The test method comprises the following steps: the ginseng and poria cocos spleen-tonifying and nourishing granule group and group a have influence on blood of a blood-deficiency mouse; effect on cyclophosphamide-induced thrombocytopenia in mice; effect on bleeding time in mice.
(I) Effect on blood of blood-deficient mice
Experimental Material
1. Animals: the weight of Kunming mouse is 18-22 g.
2. Medicine preparation: group a and the large, medium and small dosage groups of the Shenling spleen-invigorating and nourishing granules; the medicine is prepared by distilled water before experiment and administered by intragastric administration.
Experimental methods
60 Kunming mice, half of male and female, with the weight of 18-22 g, were randomly divided into 6 groups of 10 mice each. Except for the control group, the tail of each of the other 5 groups of mice was bled 0.5m1 to make the animals lose blood, which resulted in blood deficiency in blood loss, and the mice were gavaged 24 hours later. The control group and the model group are perfused with normal saline with the same volume; the ginseng and poria cocos spleen-tonifying and nourishing granules are prepared by carrying out gastric gavage administration on 16.8, 8.4 and 4.2g crude drugs/kg of large, medium and small dose components respectively; the group a is administered with 16.8g crude drug/kg by intragastric administration. Continuously administering for 7d 1 time daily, and after 2 hr of final administration, tail blood is taken for measuring hemoglobin and erythrocyte values. The experimental results are as follows: see Table 1
TABLE 1 Effect on blood of blood-deficient mice
P < 0.01 compared to model group; the ratio of delta P to group a is less than 0.05.
The results show that: the ginseng-poria spleen-tonifying and particle-nourishing group and the group a can obviously improve the levels of hemoglobin and red blood cells of mice, and have extremely obvious difference (P is less than 0.01) compared with a model group; compared with the group a, the large-dose group of the ginseng-poria spleen-invigorating and nourishing granules has significant difference (P is less than 0.05). Therefore, the ginseng-poria cocos particle group for tonifying spleen and nourishing blood has stronger blood replenishing effect than the group a.
(II) Effect on Cyclophosphamide-induced thrombocytopenia in mice
Experimental Material
1. Animals: the weight of Kunming mouse is 18-22 g.
2. Medicine preparation: group a and the large, medium and small dosage groups of the Shenling spleen-invigorating and nourishing granules; the medicine is prepared by distilled water before experiment and administered by intragastric administration.
Experimental methods
60 Kunming mice, half of male and female, with the weight of 18-22 g, were randomly divided into 6 groups of 10 mice each. Perfusing distilled water with the same volume as the control group and the model group; the ginseng and poria cocos spleen-tonifying and nourishing granules are prepared by carrying out gastric gavage administration on 16.8, 8.4 and 4.2g crude drugs/kg of large, medium and small dose components respectively; the group a is administered with 16.8g crude drug/kg by intragastric administration. The administration is continued for 15 days, 1 time per day, except for the control group, the other 5 groups of mice are injected with 100g/kg of cyclophosphamide in the abdominal cavity at 8d, 10d and 12d, which causes the reduction of the platelets of the mice, and the number of the platelets is calculated by blood collection in the orbit 2 hours after the 15d last administration. The experimental results are as follows: see Table 2
TABLE 2 Effect on Cyclophosphamide-induced thrombocytopenia in mice
P < 0.01 compared to model; the ratio of delta P to group a is less than 0.05.
The results show that: the ginseng-poria spleen-tonifying and nourishing granule group and the group a can obviously reduce the platelet reduction caused by cyclophosphamide injection, and have very significant difference (P is less than 0.01) compared with a model group; compared with the group a, the large-dose group of the ginseng-poria spleen-invigorating and nourishing granules has significant difference (P is less than 0.05). Therefore, the ginseng-poria spleen-tonifying and blood-nourishing granule group has a stronger effect of increasing blood platelets than the group a.
(III) Effect on bleeding time in mice
Experimental Material
1. Animals: the weight of Kunming mouse is 18-22 g.
2. Medicine preparation: group a and the large, medium and small dosage groups of the Shenling spleen-invigorating and nourishing granules; the medicine is prepared by distilled water before experiment and administered by intragastric administration.
Experimental methods
50 Kunming mice, each half of male and female, with the weight of 18-22 g, were randomly divided into 5 groups of 10 mice each. The control group was perfused with the same volume of normal saline; the ginseng and poria cocos spleen-tonifying and nourishing granules are prepared by carrying out gastric gavage administration on 16.8, 8.4 and 4.2g crude drugs/kg of large, medium and small dose components respectively; the group a is administered with 16.8g crude drug/kg by intragastric administration. The administration was continued for 7 days, 1 time daily. After the last administration for 1h, the blood time was measured by mouse tail-cutting. Cutting off mouse tail 1cm from tail end of mouse by using scissors, and sticking bleeding point with filter paper once every 10s when the mouse is naturally bled until no natural bleeding exists, and recording bleeding time of each group of mice. The experimental results are as follows: see Table 3
TABLE 3 Effect on bleeding time in mice
P < 0.01 compared to control; the ratio of delta P to group a is less than 0.05.
The results show that: the ginseng-poria spleen-tonifying and particle-nourishing group and the group a can obviously shorten the bleeding time of mice, and have very significant difference (P is less than 0.01) compared with a control group; compared with the group a, the large-dose group of the ginseng-poria spleen-invigorating and nourishing granules has significant difference (P is less than 0.05). Therefore, the ginseng-poria spleen-tonifying and nourishing granule group has stronger hemostatic effect than the group a.
The experimental results are as follows: the ginseng and poria cocos spleen-tonifying and particle-nourishing group and the group a can obviously improve the levels of hemoglobin and red blood cells of mice; the composition has an effect of improving the mouse thrombocytopenia caused by cyclophosphamide; can obviously shorten the bleeding time of the mice.
And (4) conclusion: the ginseng-poria spleen-tonifying and blood-nourishing granule group has stronger pharmacological actions of enriching blood and nourishing blood, increasing blood platelets, stopping bleeding and the like than the group a. Therefore, the ginseng-poria spleen-strengthening and nourishing granule group has stronger effect of treating thrombocytopenia caused by spleen and stomach weakness and qi and blood deficiency than the group a clinically.
The specific implementation mode of the invention is as follows:
the invention is further illustrated, but is not intended to be limited, by the following specific examples.
Example 1:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, making into 1000g granule, and packaging to obtain granule.
Example 2:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, and making into capsule of 1000 granules.
Example 3:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, starch and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, tabletting, and making into 1000 tablets to obtain tablet.
Example 4:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, making into 1000g granule, and packaging to obtain granule.
Example 5:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, and making into capsule of 1000 granules.
Example 6:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, starch and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, tabletting, and making into 1000 tablets to obtain tablet.
Example 7:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, making into 1000g granule, and packaging to obtain granule.
Example 8:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, and making into capsule of 1000 granules.
Example 9:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, starch and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, tabletting, and making into 1000 tablets to obtain tablet.
Example 10:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, making into 1000g granule, and packaging to obtain granule.
Example 11:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, and making into capsule of 1000 granules.
Example 12:
the invention is prepared from the following raw material medicines in parts by weight:
the preparation method comprises the following steps:
crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, starch and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, tabletting, and making into 1000 tablets to obtain tablet.
Claims (6)
1. The Chinese medicinal composition for tonifying spleen and nourishing blood is characterized by being prepared from the following raw material medicaments in part by weight:
american ginseng 150-
100g of rhizoma atractylodis, 180g of fructus amomi, 100g of astragalus, 180g of radix astragali, 180g of angelica, 150 g of angelica
Radix paeoniae alba 180-260g schisandra chinensis 50-130g and rhizoma bletillae 180-260 g.
2. The spleen-invigorating and blood-nourishing traditional Chinese medicine composition of ginseng and poria cocos as claimed in claim 1, is characterized by being prepared from the following raw material medicines in a preferable weight ratio:
american ginseng 172.8g dried orange peel 172.8g fried white atractylodes rhizome 216g poria cocos 216g
144g of rhizoma atractylodis, 144g of fructus amomi, 216g of astragalus, 172.8g of angelica sinensis
Radix paeoniae alba 216g schisandra chinensis 86.4g and bletilla striata 216 g.
3. The preparation method of the ginseng and poria cocos traditional Chinese medicine composition granules for tonifying spleen and nourishing blood according to claim 1 or 2, is characterized by comprising the following steps: crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, making into 1000g granule, and packaging to obtain granule.
4. The preparation method of the Shenling spleen-invigorating and blood-nourishing traditional Chinese medicine composition capsule as claimed in claim 1 or 2, which is characterized by comprising the following steps: crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, dextrin and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, and making into capsule of 1000 granules.
5. The preparation method of the Shenling spleen-invigorating and blood-nourishing traditional Chinese medicine composition tablet according to claim 1 or 2, which is characterized by comprising the following steps: crushing American ginseng into fine powder, adding water into ten kinds of other dried orange peel, fried bighead atractylodes rhizome, poria cocos, rhizoma atractylodis, fructus amomi, astragalus mongholicus, angelica sinensis, radix paeoniae alba, schisandra chinensis and rhizoma bletillae, decocting twice, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 1 hour for the second time, mixing decoctions, filtering, concentrating the filtrate into clear paste with the relative density of 1.20-1.25 measured at 60 ℃, adding the American ginseng fine powder, mixing uniformly, drying under reduced pressure at 70 ℃, crushing into fine powder, sieving with a 80-mesh sieve, and mixing uniformly to obtain mixed extract powder; mixing the mixed extract powder, starch and sucrose powder at a ratio of 1:0.5:1, granulating with 70% ethanol, drying at 70 deg.C, grading, tabletting, and making into 1000 tablets to obtain tablet.
6. The spleen-invigorating and blood-nourishing ginseng-poria cocos traditional Chinese medicine composition according to claim 1 or 2, is characterized by having the effects of benefiting qi, invigorating spleen, nourishing blood and stopping bleeding, and is mainly used for treating thrombocytopenia caused by spleen-stomach weakness and qi-blood deficiency.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110172129.0A CN112741883B (en) | 2021-02-08 | 2021-02-08 | Ginseng and poria cocos traditional Chinese medicine composition for tonifying spleen and nourishing blood and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110172129.0A CN112741883B (en) | 2021-02-08 | 2021-02-08 | Ginseng and poria cocos traditional Chinese medicine composition for tonifying spleen and nourishing blood and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112741883A CN112741883A (en) | 2021-05-04 |
| CN112741883B true CN112741883B (en) | 2022-02-15 |
Family
ID=75651829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110172129.0A Active CN112741883B (en) | 2021-02-08 | 2021-02-08 | Ginseng and poria cocos traditional Chinese medicine composition for tonifying spleen and nourishing blood and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112741883B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288945A (en) * | 2021-05-10 | 2021-08-24 | 河南华峰制药有限公司 | Spleen-tonifying blood-enriching granules and preparation method thereof |
| CN113750065A (en) * | 2021-09-24 | 2021-12-07 | 安徽淮仁堂药业股份有限公司 | Spleen-tonifying and lung-benefiting pill, preparation method and special processing method of raw materials |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579669B (en) * | 2012-03-05 | 2013-09-04 | 宁夏紫荆花制药有限公司 | Chinese medicinal composition for nourishing qi and blood and conditioning menstruation and preparation method thereof |
| CN108721429A (en) * | 2017-04-25 | 2018-11-02 | 孙宁振 | A kind of Traditional Chinese medicinal prescription of rich in nutrition |
| CN108478745A (en) * | 2018-06-05 | 2018-09-04 | 陕西郝其军制药股份有限公司 | One seed ginseng Chinese herbaceous peony nourishing qi and blood particle Chinese medicine composition and preparation method thereof |
-
2021
- 2021-02-08 CN CN202110172129.0A patent/CN112741883B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN112741883A (en) | 2021-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112741883B (en) | Ginseng and poria cocos traditional Chinese medicine composition for tonifying spleen and nourishing blood and preparation method thereof | |
| CN1305483C (en) | Heart failure regulating Chinese medicine | |
| CN104940531A (en) | Application of Chinese herbal composition to preparation of medicine for treating diabetic nephropathy | |
| CN101537120A (en) | Health care product for maintaining beauty and lengthening life | |
| CN103099833A (en) | Soft capsule helpful for relieving sports fatigue and delaying aging and preparation method thereof | |
| CN101926942A (en) | Glucose-lowering health care medicinal tea and preparation method thereof | |
| CN108283668A (en) | A kind of gastric ulcer composition of American-cockroach-extract-containing and preparation method thereof | |
| CN103263582A (en) | Weight losing prescription | |
| CN1242794C (en) | Chinese traditional medicine preparation for treating leucocythemia and solid tumor | |
| CN107536016B (en) | A nutritional food for protecting heart and promoting liver health | |
| CN104984027A (en) | Chinese materia medica preparation for treating myelodysplastic syndrome and preparation method thereof | |
| CN104984141A (en) | Prescription for treating constipation and preparation method thereof | |
| CN104587300A (en) | Traditional Chinese medicine composition for treating acute leukemia and preparation method of traditional Chinese medicine composition | |
| CN110368469A (en) | Join glue stilbene particle drink | |
| CN105396022A (en) | Preparation method of pharmaceutical tablet alleviating tumor patient radiotherapy reaction | |
| CN102085274A (en) | Traditional Chinese medicine composition for treating acute, chronic and subacute leukemia and preparation method thereof | |
| CN116270830B (en) | Anti-radiation traditional Chinese medicine composition and application thereof | |
| CN102091181A (en) | Chinese medicinal composition for treating acute and chronic granulocytic leukemia 1 and preparation method thereof | |
| CN100411670C (en) | Medicine for treating tumor in upper digestive tract and its preparing method | |
| CN112717064A (en) | Blood-cooling and qi-tonifying traditional Chinese medicine composition containing chrysanthemum and preparation method thereof | |
| CN104873918A (en) | Traditional Chinese medicine preparation for treating gastroptosis and preparation method thereof | |
| CN104958502A (en) | Traditional Chinese medicine composition for treating gastropathy and preparation method thereof | |
| CN104547695B (en) | It is a kind of for treating the pharmaceutical composition and its application of trigeminal neuralgia | |
| CN102579875B (en) | Liver-protecting bamboo-shoot product and preparation method thereof | |
| CN102579683A (en) | Chinese medicinal composition for treating acute and chronic lymphoid leukemia and development method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |