CN112739367B - Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途 - Google Patents

Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途 Download PDF

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CN112739367B
CN112739367B CN201980059209.6A CN201980059209A CN112739367B CN 112739367 B CN112739367 B CN 112739367B CN 201980059209 A CN201980059209 A CN 201980059209A CN 112739367 B CN112739367 B CN 112739367B
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peptide
amino acid
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aspects
acid
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CN112739367A (zh
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D·克里斯滕森
J·J·科冷
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Ryan Treatment Co
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Ryan Treatment Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201980059209.6A 2018-09-10 2019-09-10 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途 Active CN112739367B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510609954.0A CN121159628A (zh) 2018-09-10 2019-09-10 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途

Applications Claiming Priority (3)

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US201862728997P 2018-09-10 2018-09-10
US62/728997 2018-09-10
PCT/US2019/050332 WO2020055812A1 (en) 2018-09-10 2019-09-10 Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis

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CN202510609954.0A Division CN121159628A (zh) 2018-09-10 2019-09-10 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途

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CN112739367A CN112739367A (zh) 2021-04-30
CN112739367B true CN112739367B (zh) 2025-06-06

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CN202510609954.0A Pending CN121159628A (zh) 2018-09-10 2019-09-10 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途

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US (3) US11905336B2 (enExample)
EP (1) EP3849580A4 (enExample)
JP (3) JP7496826B2 (enExample)
KR (1) KR20210084453A (enExample)
CN (2) CN112739367B (enExample)
AU (2) AU2019339260B2 (enExample)
BR (1) BR112021004404A2 (enExample)
CA (1) CA3111563A1 (enExample)
WO (1) WO2020055812A1 (enExample)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
PT3929207T (pt) 2013-03-15 2024-10-21 Univ Texas Utilização do péptido fttftvt no tratamento de fibrose
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US20230159608A1 (en) * 2020-04-21 2023-05-25 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and uses thereof
EP4168031A4 (en) * 2020-06-19 2024-07-10 Lung Therapeutics, LLC MODIFIED CAVEOLIN-1 PEPTIDES FOR THE TREATMENT OF PATHOGEN-INDUCED LUNG LESION
WO2022182949A2 (en) 2021-02-25 2022-09-01 Lung Therapeutics, Inc. Biomarkers for the treatment of interstitial lung disease
WO2022266410A1 (en) * 2021-06-17 2022-12-22 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of post-acute covid-19
AU2022371643A1 (en) * 2021-10-22 2024-05-02 Rein Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of chronic kidney disease
CN119661656A (zh) * 2024-11-20 2025-03-21 华中科技大学同济医学院附属梨园医院 一种靶向拮抗pCAV1的多肽及其应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN107405379A (zh) * 2015-02-27 2017-11-28 得克萨斯州大学系统董事会 多肽治疗剂和其用途

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BR112021004404A2 (pt) 2021-08-03
JP2024071397A (ja) 2024-05-24
EP3849580A4 (en) 2022-06-15
EP3849580A1 (en) 2021-07-21
JP7496826B2 (ja) 2024-06-07
WO2020055812A1 (en) 2020-03-19
US20210347820A1 (en) 2021-11-11
AU2025234225A1 (en) 2025-10-09
CA3111563A1 (en) 2020-03-19
KR20210084453A (ko) 2021-07-07
CN112739367A (zh) 2021-04-30
US12497431B2 (en) 2025-12-16
US20240018186A1 (en) 2024-01-18
US11787838B2 (en) 2023-10-17
AU2019339260B2 (en) 2025-06-26
JP2022500078A (ja) 2022-01-04
JP2025184877A (ja) 2025-12-18
AU2019339260A1 (en) 2021-03-25
CN121159628A (zh) 2025-12-19
US20230212223A1 (en) 2023-07-06
US11905336B2 (en) 2024-02-20
JP7737492B2 (ja) 2025-09-10

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