CN112730389A - Chemiluminescence detection device - Google Patents
Chemiluminescence detection device Download PDFInfo
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- CN112730389A CN112730389A CN202011568203.2A CN202011568203A CN112730389A CN 112730389 A CN112730389 A CN 112730389A CN 202011568203 A CN202011568203 A CN 202011568203A CN 112730389 A CN112730389 A CN 112730389A
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- module
- reagent strip
- guide rail
- incubation
- detection device
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- 238000002038 chemiluminescence detection Methods 0.000 title claims abstract description 16
- 230000007246 mechanism Effects 0.000 claims abstract description 71
- 238000011534 incubation Methods 0.000 claims abstract description 23
- 238000004140 cleaning Methods 0.000 claims abstract description 15
- 239000003153 chemical reaction reagent Substances 0.000 claims description 46
- 238000001514 detection method Methods 0.000 claims description 12
- 230000005540 biological transmission Effects 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 abstract description 13
- 230000008569 process Effects 0.000 abstract description 6
- 238000012360 testing method Methods 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 description 6
- 230000012447 hatching Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 238000007726 management method Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
- G01N21/763—Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention relates to the technical field of chemiluminescence detection, and discloses a chemiluminescence detection device, which comprises a pipetting mechanical arm mechanism, a card feeding mechanism, an incubation module, a cleaning module, a carrying module, a reading module and a casing, wherein the bottom end of the casing is bolted with a table top, the bottom of the outer side of the casing is hinged with a lower cover, a touch screen is embedded above the lower cover, the upper surface of the table top is fixedly connected with a sample rack and a gun head box, the pipetting mechanical arm mechanism comprises a moving guide rail and a sample adding head, the bottom end of the sample adding head is of an electric telescopic structure, the invention adopts the incubation module, the carrying module, the cleaning module and the reading module, realizes incubation, carrying, cleaning and final reading procedures of samples by matching with the guide rails connected with the components, and realizes continuous and quick whole testing process and tight matching among the mechanisms by mechanical control in the whole process, is superior to the traditional chemiluminescence detection equipment.
Description
Technical Field
The invention relates to the technical field of chemiluminescence detection, in particular to a chemiluminescence detection device.
Background
The mechanisms in the existing chemiluminescence detection equipment are large-scale integrated mechanisms, so that the traditional chemiluminescence detection equipment is large-scale equipment, the management, transportation and use are greatly limited, the requirements of clinical bedside monitoring or emergency follow-up detection are difficult to meet, the overall running time of the equipment is long, the key points of the portable and bedside diagnosis for medical quick detection are difficult to meet, the traditional equipment cannot meet the requirements, and for small-batch chemiluminescence tests, the traditional equipment cannot be filled with reagent strip test racks, the utilization rate of the equipment is often insufficient, the energy consumption of the equipment is increased by space, and for testers, more time is required for monitoring the equipment to wait for test results.
Disclosure of Invention
The present invention is directed to a chemiluminescence detection apparatus, which solves the problems of the background art mentioned above.
In order to achieve the purpose, the invention provides the following technical scheme:
the portable multifunctional automatic liquid transferring machine comprises a liquid transferring mechanical arm mechanism, a card feeding mechanism, an incubation module, a cleaning module, a carrying module, a reading module and a casing, wherein a table top is bolted at the bottom end of the casing, a lower cover is hinged at the bottom outside the casing, a touch screen is embedded above the lower cover, a sample frame and a gun head box are fixedly connected to the upper surface of the table top, the liquid transferring mechanical arm mechanism comprises a moving guide rail and a sample adding head, the liquid transferring mechanical arm mechanism is connected with the moving guide rail in a sliding mode through a sliding rod, one end of the moving guide rail is connected with the sample adding head in a sliding mode, and the bottom end of;
the reagent strip feeding mechanism comprises a reagent strip frame and a pushing guide rail, the reagent strip frame is clamped at the upper part of the reagent strip feeding mechanism, the pushing guide rail is arranged at the lower part of the reagent strip feeding mechanism, and a push plate is arranged at the upper part of the pushing guide rail and penetrates through the middle part of the reagent strip frame;
the utility model discloses a hatching module, including hatching module, slide rail bolt connection, the module is hatched to the slide rail bolt connection and is included drive motor, reagent strip mounting bracket, drive mechanism and slide rail, the slide rail bolt is in the bottom of hatching the module, and the upper portion sliding connection of slide rail has the reagent strip mounting bracket, drive motor is connected with the drive mechanism transmission, the outside of reagent strip mounting bracket and drive mechanism's fixed connection, the inside of hatching the module still is provided with heating mechanism and temperature sensor.
As a still further scheme of the invention: the motion guide rail and the slide bar on the liquid-transferring mechanical arm mechanism are vertically arranged at 90 degrees.
As a still further scheme of the invention: a rotating motor is arranged inside the carrying module, and a carrier is fixedly connected to the top of the rotating motor.
As a still further scheme of the invention: the carrying module is connected to one end of the guide rail in a sliding mode, and the other end of the guide rail is fixedly connected with the table board.
As a still further scheme of the invention: the pipetting mechanical arm mechanism, the card feeding mechanism, the incubation module, the cleaning module, the carrying module and the reading module are all bolted on the upper surface of the table board through bolts, and the incubation module is arranged between the card feeding mechanism and the carrying module.
Compared with the prior art, the invention has the beneficial effects that:
1. the invention adopts the incubation module, the carrying module, the cleaning module and the reading module, realizes incubation, carrying, cleaning and final reading procedures of a sample by matching with the guide rails connected with all the parts, and realizes full-process mechanical automatic control, so that the whole testing process is coherent and quick, the matching among mechanisms is tight, and the invention is superior to the traditional chemiluminescence detection equipment.
2. The incubation module adopts a square structure at present, a reagent strip is added and incubated by the card feeding mechanism, the reagent strip is added and incubated by the sample adding arm mechanism, the incubation module provides heating to meet the incubation of the reagent strip, the left-right sliding of the guide rail is matched to align the carrying module to push out the reagent strip, and then the cleaning and reading in the reagent strip are realized by the rotation and the turning of the carrying module, so that the space of the whole device is applied in the largest range, the volume of the device is greatly reduced while the detection is ensured, the management, the transportation and the use of the device are greatly improved, and the traditional large-scale detection device is evolved to a small-size and medium-size detection device.
Drawings
FIG. 1 is a top view of the internal structure of the present invention;
FIG. 2 is a schematic view of the overall structure of the housing of the present invention;
FIG. 3 is a schematic structural view of an incubation module of the present invention;
FIG. 4 is a schematic structural diagram of a card feeding mechanism of the present invention;
FIG. 5 is a schematic structural view of a carrier module of the present invention;
fig. 6 is a schematic structural view of the pipetting robot arm mechanism of the present invention.
In the figure: 1. a pipetting mechanical arm mechanism; 2. a card feeding mechanism; 3. a sample rack; 4. a table top; 5. an incubation module; 6. a cartridge for the gun head; 7. a cleaning module; 8. a carrier module; 9. a reading module; 10. a guide rail; 11. a housing; 12. a touch screen; 13. a lower machine cover; 14. a drive motor; 15. a reagent strip mounting rack; 16. a transmission mechanism; 17. a slide rail; 18. a reagent strip holder; 19. advancing the guide rail; 20. a rotating electric machine; 21. a carrier; 22. a moving guide rail; 23. and a sample adding head.
Detailed Description
Referring to fig. 1-4, in an embodiment of the invention, a chemiluminescence detection device,
the device comprises a pipetting mechanical arm mechanism 1, a card feeding mechanism 2, an incubation module 5, a cleaning module 7, a carrying module 8, a reading module 9 and a casing 11, wherein a table top 4 is bolted at the bottom end of the casing 11, a lower cover 13 is hinged at the bottom of the outer side of the casing 11, a touch screen 12 is embedded above the lower cover 13, a sample rack 3 and a gun head box 6 are fixedly connected to the upper surface of the table top 4, the pipetting mechanical arm mechanism 1 comprises a motion guide rail 22 and a sampling head 23, the pipetting mechanical arm mechanism 1 is slidably connected with the motion guide rail 22 through a slide bar, one end of the motion guide rail 22 is slidably connected with the sampling head 23, and the bottom end of the sampling head 23 is of an electric telescopic structure;
the card feeding mechanism 2 comprises a reagent strip rack 18 and a pushing guide rail 19, the reagent strip rack 18 is clamped at the upper part of the card feeding mechanism 2, the pushing guide rail 19 is arranged at the lower part of the card feeding mechanism 2, and a push plate is arranged at the upper part of the pushing guide rail 19 and penetrates through the middle part of the reagent strip rack 18;
Wherein, the motion guide rail 22 becomes 90 perpendicular settings with the slide bar on the liquid-transfering mechanical arm mechanism 1, utilizes the motion guide rail 22 and the slide bar on the liquid-transfering mechanical arm mechanism 1 to realize the removal on X and Y axle, and the application of sample head 23 bottom is electronic extending structure, can let whole liquid-transfering mechanical arm mechanism realize X, Y, Z's three-dimensional removal, has great improvement to the accuracy of sample.
Wherein, a rotating motor 20 is arranged inside the carrying module 8, and a carrier frame 21 is fixedly connected to the top of the rotating motor 20.
The carrying module 8 is slidably connected to one end of the guide rail 10, the other end of the guide rail 10 is fixedly connected to the table top 4, the reagent strips placed on the rack 21 are rotated from the longitudinal direction to the transverse direction by the rotating motor 20 on the carrying module 8, and the reagent strips are moved to the reading module 9 to be read by matching with the guide rail 10.
Wherein, move liquid arm mechanism 1, advance card mechanism 2, incubate module 5, wash module 7, delivery module 8 and reading module 9 and all peg graft in the upper surface of mesa 4 through the bolt, it sets up between card mechanism 2 and the delivery module 8 to incubate module 5, utilizes the propulsion guide rail 19 that advances card mechanism 2 to push the reagent strip into to incubate module 5 in heat and incubate.
The working principle of the invention is as follows: firstly, an empty reagent strip is placed in a card feeding mechanism 2, then the reagent strip is pushed into an incubation module 5 in sequence by the card feeding mechanism 2, a pipette tip is taken from a pipette tip box 6 by a pipette tip mechanical arm mechanism 1 to add a sample in a sample rack 3 into the reagent strip, then the pipette tip is replaced from the pipette tip box 6 to suck a reagent sealed in the reagent strip for mixing, then a heating mechanism and a temperature sensor are opened to reach and keep a set temperature when the equipment starts to operate in the incubation module 5, the sample reagent strip is added into the incubation module 5 for incubation reaction, after the incubation time is reached, a transmission motor 14 drives a transmission mechanism 16, so that the transmission mechanism 16 drives a reagent strip mounting rack 15 to move on a slide rail 17, after the reagent strip is out of a clamping position, the reagent strip is pushed out of an outlet to a carrying module 8 by the pushing mechanism, and then a cleaning module 7 cleans a substrate in the reagent strip, after the cleaning step is completed, the carrying module 8 controls the rotating motor 20 to rotate the reagent strip from the longitudinal direction to the transverse direction, then the reagent strip is carried to a reading module 9 by a guide rail 10, the liquid mechanical arm mechanism 1 takes the gun head from the gun head box 6 to add the substrate in the substrate bottle in the sample rack 3 into the reagent strip, then the reading module 9 is used for reading and detecting the sample in the reagent strip, the whole mechanism adopts mechanized control to realize the procedures of sample adding, incubation, carrying, cleaning and final reading of the sample, the whole chemiluminescence detection device has small volume and accuracy, the detection sample can realize the detection at any time and the batch detection for some detection samples needing emergent results, the detection device has the advantages of large utilization rate, high working efficiency, large help for management, transportation and use of equipment, low transportation difficulty, small use space and suitability for wide popularization and application.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation. The use of the phrase "comprising one of the elements does not exclude the presence of other like elements in the process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. A chemiluminescence detection device comprises a pipetting mechanical arm mechanism (1), a card feeding mechanism (2), an incubation module (5), a cleaning module (7), a carrying module (8), a reading module (9) and a machine shell (11), it is characterized in that the bottom end of the casing (11) is bolted with a table top (4), the bottom of the outer side of the casing (11) is hinged with a lower machine cover (13), a touch screen (12) is embedded above the lower machine cover (13), a sample frame (3) and a gun head box (6) are fixedly connected to the upper surface of the table top (4), the liquid-transferring mechanical arm mechanism (1) comprises a moving guide rail (22) and a sample adding head (23), the liquid-transferring mechanical arm mechanism (1) is connected with a moving guide rail (22) through a sliding rod in a sliding way, one end of the motion guide rail (22) is connected with a sample adding head (23) in a sliding manner, and the bottom end of the sample adding head (23) is of an electric telescopic structure;
the feeding mechanism (2) comprises a reagent strip frame (18) and a pushing guide rail (19), the reagent strip frame (18) is clamped at the upper part of the feeding mechanism (2), the pushing guide rail (19) is arranged at the lower part of the feeding mechanism (2), and a push plate is arranged at the upper part of the pushing guide rail (19) and penetrates through the middle part of the reagent strip frame (18);
incubate module (5) including drive motor (14), reagent strip mounting bracket (15), drive mechanism (16) and slide rail (17), slide rail (17) bolt in the bottom of incubating module (5), and the upper portion sliding connection of slide rail (17) has reagent strip mounting bracket (15), drive motor (14) are connected with drive mechanism (16) transmission, the outside of reagent strip mounting bracket (15) and the fixed connection of drive mechanism (16), the inside of incubating module (5) still is provided with heating mechanism and temperature sensor.
2. A chemiluminescent detection device according to claim 1 wherein the motion guide (22) is arranged at 90 ° to the slide bar on the pipetting robot mechanism (1).
3. A chemiluminescence detection device according to claim 1, wherein a rotating motor (20) is arranged inside the carrier module (8), and a carrier rack (21) is fixedly connected to the top of the rotating motor (20).
4. A chemiluminescent detection device according to claim 1 wherein the carrier module (8) is slidably connected to one end of a rail (10), the other end of the rail (10) being fixedly connected to the table top (4).
5. The chemiluminescence detection device according to claim 1, wherein the pipetting robot arm mechanism (1), the clamping mechanism (2), the incubation module (5), the cleaning module (7), the carrying module (8) and the reading module (9) are bolted to the upper surface of the table top (4) through bolts, and the incubation module (5) is arranged between the clamping mechanism (2) and the carrying module (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011568203.2A CN112730389B (en) | 2020-12-26 | 2020-12-26 | Chemiluminescence detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011568203.2A CN112730389B (en) | 2020-12-26 | 2020-12-26 | Chemiluminescence detection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112730389A true CN112730389A (en) | 2021-04-30 |
| CN112730389B CN112730389B (en) | 2024-10-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011568203.2A Active CN112730389B (en) | 2020-12-26 | 2020-12-26 | Chemiluminescence detection device |
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| Country | Link |
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| CN (1) | CN112730389B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113866445A (en) * | 2021-09-26 | 2021-12-31 | 江苏拜明生物技术有限公司 | Card feeding mechanism with preheating function |
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| CN107389962A (en) * | 2017-09-21 | 2017-11-24 | 苏州新波生物技术有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter for possessing multiple independent reaction passages |
| CN110412302A (en) * | 2019-07-30 | 2019-11-05 | 香港大德昌龙生物科技有限公司 | Single part chemical analysis device and its method for analyzing sample |
| CN214041165U (en) * | 2020-12-26 | 2021-08-24 | 江苏拜明生物技术有限公司 | Chemiluminescence detection device |
-
2020
- 2020-12-26 CN CN202011568203.2A patent/CN112730389B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105181591A (en) * | 2015-08-03 | 2015-12-23 | 基蛋生物科技股份有限公司 | Biochemical immune mixed analysis system and device |
| WO2017128806A1 (en) * | 2016-01-27 | 2017-08-03 | 广州万孚生物技术股份有限公司 | Automatic fluorescence quantitative immunoassay analyzer and detection method |
| CN107167584A (en) * | 2017-05-27 | 2017-09-15 | 北京热景生物技术股份有限公司 | Chemical illumination immunity analysis instrument |
| CN107389962A (en) * | 2017-09-21 | 2017-11-24 | 苏州新波生物技术有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter for possessing multiple independent reaction passages |
| CN110412302A (en) * | 2019-07-30 | 2019-11-05 | 香港大德昌龙生物科技有限公司 | Single part chemical analysis device and its method for analyzing sample |
| CN214041165U (en) * | 2020-12-26 | 2021-08-24 | 江苏拜明生物技术有限公司 | Chemiluminescence detection device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113866445A (en) * | 2021-09-26 | 2021-12-31 | 江苏拜明生物技术有限公司 | Card feeding mechanism with preheating function |
| CN113866445B (en) * | 2021-09-26 | 2023-11-28 | 江苏拜明生物技术有限公司 | Card feeding mechanism with preheating function |
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| CN112730389B (en) | 2024-10-01 |
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