CN112716858B - Plant composite whitening and freckle removing nursing composition, and emulsion and cream containing composition - Google Patents
Plant composite whitening and freckle removing nursing composition, and emulsion and cream containing composition Download PDFInfo
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- CN112716858B CN112716858B CN202110134302.8A CN202110134302A CN112716858B CN 112716858 B CN112716858 B CN 112716858B CN 202110134302 A CN202110134302 A CN 202110134302A CN 112716858 B CN112716858 B CN 112716858B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The application relates to the field of cosmetics, and particularly discloses a plant composite whitening and freckle removing nursing composition, and emulsion and cream containing the composition. The plant composite whitening and freckle removing nursing composition comprises 0.05-1 part of alpha-arbutin; 0.1-5 parts of octadecenedioic acid; 0.02-0.4 part of solidago virgaurea extract; 0.01-0.2 parts of emulsifier. The preparation method of the composition comprises the following steps: adding alpha-arbutin, octadecenedioic acid and solidago virgaurea extract into an emulsifier, stirring at the temperature of 30-40 ℃, rotating at the speed of 30-40 r/min, stirring for 10-20 min, and cooling to room temperature to obtain the plant composite whitening and freckle removing nursing composition. The composition can be used in lotion and cream, and has the advantages of safety of herbaceous plants, excellent whitening and freckle removing effects and good skin moisturizing performance.
Description
Technical Field
The application relates to the field of skin care products, in particular to a plant composite whitening and freckle removing nursing composition, and emulsion and cream containing the composition.
Background
With the progress of science and technology, people are also intensively researched in the field of skin care, and especially the problems of whitening and freckle removal are always troubled, the most direct reason for skin blackening and pigmented spots is caused by melanin deposition, the melanin deposition is considered to be protective adaptation in the evolution process of human beings, and the destructive influence caused by direct exposure of organisms to direct sunlight, such as DNA damage and mutation caused by sunlight burn, photoaging and ultraviolet rays, can not be recovered to the original skin brightness for a long time after the organisms are usually tanned, so that people are disturbed.
The source of melanin is melanocytes of a basal layer, the melanocytes secrete Maillarin pigment, when ultraviolet rays irradiate the skin, the skin is in a self-protection state, the Maillarin pigment is stimulated by the ultraviolet rays, the activity of tyrosinase is activated, the melanocytes can continuously supply melanin like 'spring eyes', 1 dendrite of the melanocytes extends to about 35 keratin cells around the melanocytes to form a melanin unit, the melanin can move upwards from a horny layer along with the metabolism of skin epidermal cells and then is separated from the skin together with aged horny, and the control of the deposition of the melanin can be realized by controlling the tyrosinase.
According to the national cosmetic safety technical specification, the allowable addition amount of each cosmetic raw material in the skin care product is limited, so that the whitening and freckle removing product realizes better whitening and freckle removing effects by adding various whitening and freckle removing components. In view of the above-mentioned related technologies, the inventors believe that in order to achieve excellent whitening and freckle-removing effects by reducing the deposition of melanin from different angles through a plurality of components, components with strong whitening and freckle-removing effects are usually added, but the superposition of these components often causes mutual inhibition among the components, so that the whitening and freckle-removing effects are difficult to further break through, and there are cases where the whitening effect is basically unchanged or even the effect is reduced, and therefore, there is room for improvement.
Disclosure of Invention
In order to achieve better whitening and freckle removing effects, the application provides a plant composite whitening and freckle removing nursing composition, and emulsion and cream containing the composition.
In a first aspect, the application provides a plant composite whitening and freckle removing nursing composition, which adopts the following technical scheme:
a plant composite whitening and freckle removing nursing composition comprises the following components in parts by weight:
0.05-1 part of alpha-arbutin;
0.1-5 parts of octadecenedioic acid;
0.02-0.4 part of solidago virgaurea extract;
0.01-0.2 parts of emulsifier.
Preferably, the plant composite whitening and freckle removing nursing composition comprises the following components in parts by weight:
0.4-0.6 parts of alpha-arbutin;
1.5-2.5 parts of octadecenedioic acid;
0.15-0.25 part of solidago virgaurea extract;
0.08-0.12 part of emulsifier.
By adopting the technical scheme, the alpha-arbutin can directly inhibit the activity of monophenolase in tyrosinase, so that the tyrosinase and tyrosine have weaker binding capacity, the generation of dopamine is reduced, the generation of melanin is further reduced, the alpha-arbutin is generated by carrying out a sugar transfer reaction through enzymes of different microorganisms, the components are safe, the expression of tyrosinase genes can be adjusted by adding octadecenedioic acid, the generation of tyrosinase is reduced, the generation of melanin is further reduced, due to the adoption of the goldenrod lanuginose extract, the goldenrod lanuginose-containing extract can converge pores of skin, the wound healing is accelerated, the skin health state is improved, the goldenrod lanuginose extract has no negative influence on the whitening and freckle removing effects, and the mutual inhibition of the alpha-arbutin and the octadecenedioic acid on the aspect of reducing melanin can be relieved, the nursing composition firstly stimulates a peroxisome proliferator receptor (PPAR), reduces the MRNA expression of the tyrosinase after being combined with the PPAR, can inhibit the activity of the generated tyrosinase, has weaker combination ability of the tyrosinase and the tyrosine, reduces the generation of melanin through two ways, and greatly improves the whitening and freckle removing effects of the nursing composition.
Preferably, the emulsifier is octyldodecanol.
By adopting the technical scheme, the octyl dodecanol is used as the emulsifier, so that the composition is good in stability, and meanwhile, the octyl dodecanol has a good transdermal effect, so that the nursing composition can well permeate into skin, the effective ingredients can be better absorbed by the skin, and the whitening and freckle removing effects of the nursing composition are better.
Preferably, the feed also comprises the following components in parts by mass:
0.005-0.067 parts of octyl dodecanol oleate;
0.005-0.133 parts of octyl dodecanol stearoyl stearate.
By adopting the technical scheme, the emollient compounded by octyl dodecanol oleate and octyl dodecanol stearoyl oxy stearate is added, so that the components in a composition system have better dispersion effect, the texture and stability of the composition can be effectively improved, meanwhile, the emollient is from plants, has better safety, can be more gently kept on the surface of the skin, better reduces the loss of water, protects the skin barrier, enables the skin not to be easily damaged by the outside, and enables the skin to be soft and not easy to be inflamed.
Preferably, the composition further comprises 0.1-5 parts of nicotinamide by mass.
By adopting the technical scheme, through adding the nicotinamide, after the formation of the melanin is inhibited by the alpha-arbutin, the octadecenedioic acid nicotinamide and the solidago virgaurea extract, the activity of the generated melanin can be inhibited, the melanin is transferred to the keratinocyte, the melanin can be effectively inhibited from being transferred from the melanocyte to the keratinocyte by the aid of the nicotine, the appearance of the melanin on an epidermal layer can be reduced, the deposition of the melanin on the skin is reduced on a transfer path, and accordingly the whitening and freckle-removing effects of the care composition are further improved.
Preferably, the composition further comprises the following components in parts by mass:
0.02-0.4 part of rosemary leaf extract;
0.02-0.4 parts of ribes nigrum seed oil;
0.02-0.4 parts of peony root extract.
By adopting the technical scheme, through the compounding of the myrobalan extract, the ribes nigrum seed oil and the peony root extract, the composition can inhibit arachidonic acid from producing leukotriene, prostaglandin, etc. under the action of lipid oxidase and cyclooxygenase, reduce inflammation such as red swelling and pricking pain, so that the nursing composition has good function of controlling inflammation and anti-allergy, and simultaneously due to the existence of the active site of the phenol diterpenoid, the phenols are added to each other to show the whole oxidation resistance, so that the nursing composition inhibits the progress of the peroxide chain reaction by capturing the peroxy free radicals, because the generated phenolic oxygen free radicals are relatively stable and react with lipoid slowly, the free radical chain transmission and growth are blocked, the progress of an oxidation process is inhibited, and melanin is not easy to generate, so that the whitening and freckle removing effects of the composition are further improved.
Preferably, the preparation method of the composition comprises the following steps: adding alpha-arbutin, octadecenedioic acid and the extract of the Solidago virgaurea into an emulsifier, stirring at the temperature of 30-40 ℃, rotating at the speed of 30-40 r/min, stirring for 10-20 min, and cooling to room temperature to obtain the plant composite whitening and freckle removing nursing composition.
Preferably, the preparation method of the composition comprises the following steps: adding 0.01-0.2 part of emollient into an emulsifier, stirring at 60-70 ℃ at the rotating speed of 20-40 r/min, stirring for 10-20 min, cooling to 30-40 ℃ to obtain an emollient mixture, adding 0.02-0.4 part of rosemary leaf extract, 0.02-0.4 part of ribes nigrum seed oil, 0.02-0.4 part of peony root extract, alpha-arbutin, octadecenedioic acid and solidago hirsutella extract into the emollient mixture at the rotating speed of 30-40 r/min, stirring for 10-20 min, and cooling to room temperature to obtain the plant composite whitening and freckle removing care composition.
According to the technical scheme, the emollient is stirred at a high temperature, and the active substances for whitening and removing the freckles are stirred at a low temperature, so that the active ingredients in the composition are not easy to lose in the processing process, and the property state of the composition is stable.
In a second aspect, the application provides an emulsion containing a plant composite whitening and freckle removing care composition, and the following technical scheme is adopted:
an emulsion containing a plant composite whitening and freckle removing nursing composition comprises the following components in parts by weight:
40-80 parts of a solvent;
10-20 parts of an emollient;
5-15 parts of an alcohol humectant;
1.5-4 parts of a stearate surfactant;
0.5-1 part of a thickening agent;
0.02-0.08 part of pH regulator;
10-20 parts of an emollient;
5-15 parts of an alcohol humectant;
1.5-4 parts of a stearate surfactant;
0.5-1 part of a thickening agent;
0.02-0.08 part of pH regulator;
0.35-13 parts of any one of the plant composite whitening and freckle removing nursing compositions;
the total mass portion of the solvent added to the emulsion is 100 portions.
By adopting the technical scheme, the nursing composition is matched with the components such as the emollient, the alcohol humectant, the stearate surfactant and the like to form the emulsion, so that the emulsion forms a stable emulsifying system, the formed emulsion is mild, has good compatibility with the skin and has lower irritation to the skin and eyes, and the components are mutually coordinated, so that the whitening and freckle-removing components of the composition can better act on the skin, and the emulsion has better whitening and freckle-removing effects.
In a third aspect, the application provides a cream containing a plant composite whitening and freckle removing nursing composition, which adopts the following technical scheme:
a cream containing a plant composite whitening and freckle removing nursing composition comprises the following components in parts by weight:
10-20 parts of an emollient;
5-15 parts of an alcohol humectant;
1.5-4 parts of a stearate surfactant;
1.5-2 parts of a thickening agent;
0.02-0.08 part of pH regulator;
0.35-13 parts of any one of the plant composite whitening and freckle removing nursing compositions;
the total mass portion of the solvent added to the emulsion is 100 portions.
By adopting the technical scheme, the nursing composition is matched with the components such as the emollient, the alcohol humectant, the stearate surfactant and the like to form the cream, so that the cream is easy to push away, the effective ingredients in the cream uniformly act on the skin and are better absorbed by the skin, and the whitening, freckle removing, skin moistening and anti-inflammatory effects of the cream are better.
In summary, the present application has the following beneficial effects:
1. according to the application, the solidago virgaurea extract is adopted, the mutual inhibition of alpha-arbutin and octadecenedioic acid in the aspect of reducing melanin is relieved, a peroxisome proliferator receptor (PPAR) is firstly stimulated by a nursing composition, the MRNA expression of tyrosinase is reduced after the nursing composition is combined with the PPAR, the activity of the generated tyrosinase can be inhibited later, the combination capability of the tyrosinase and the tyrosine is weaker, the generation of the melanin is reduced through two ways, and the nursing composition has a better whitening and freckle removing effect.
2. The emollient that preferentially adopts octyl dodecanol oleate and octyl dodecanol stearoyl-oxy stearate to compound in this application comes from the plant, and the security is better, can keep on the skin surface more mildly, replaces the lipid of loss in the stratum corneum, reduces the scaly skin, improves skin appearance to make skin soft, pliable.
3. The compound of the myrobalan extract, the ribes nigrum seed oil and the peony root extract is preferentially adopted in the application, so that the nursing composition has a good inflammation control effect, is antiallergic, simultaneously blocks the transmission and growth of a free radical chain, inhibits the progress of an oxidation process, enables melanin not to be easily generated, and further improves the whitening and freckle removing effects of the composition.
Detailed Description
The present application will be described in further detail below with reference to tables, preparation examples, and application examples.
The sources of materials used in the application examples are as follows:
the polydimethylsiloxane was sourced from DC 350 from dow corning corporation.
Ribes nigrum seed oil, peony root extract, rosemary leaf extract, and solidago virgaurea extract are from INNOVACOS corporation.
Niacinamide is from imperial groups in the netherlands.
The alpha-arbutin is from Guangdong Leerkang Biotech GmbH.
Octadecenedioic acid is derived from Mediatone octadecenedioic acid from stadamard corporation.
The hydrogenated polyisobutene is derived from squalane from Nippon fat Co.
The sodium hyaluronate is derived from sodium hyaluronate stock solution of Shandong Furuida pharmaceutical group, Inc.
Preparation example of plant composite whitening and freckle removing nursing composition
Preparation example 1
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid and solidago virgaurea extract.
The emulsifier in this preparation is octyldodecanol.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 0.5Kg of alpha-arbutin, 1Kg of octadecenedioic acid, 0.2Kg of solidago virgaurea extract and 0.1Kg of octyldodecanol into an emulsifying pot, stirring at 30 ℃ and 30r/min for 10min, and cooling to room temperature to obtain the plant composite whitening and freckle removing nursing composition.
Preparation example 2
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid and solidago virgaurea extract.
The emulsifier in this preparation is sodium lauryl sulfate.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 4Kg of alpha-arbutin, 15Kg of octadecenedioic acid, 1.5Kg of solidago virgaurea extract and 0.8Kg of sodium dodecyl sulfate into an emulsifying pot, stirring at 35 ℃ and at 35r/min, cooling to room temperature after stirring for 15min, and thus obtaining the plant composite whitening and freckle removing nursing composition.
Preparation example 3
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid and solidago virgaurea extract.
The emulsifier in this preparation is a fatty acid glyceride.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 6Kg of alpha-arbutin, 25Kg of octadecenedioic acid, 2.5Kg of solidago virgaurea extract and 1.2Kg of fatty glyceride into an emulsifying pot, stirring at 35 ℃ and at 35r/min, cooling to room temperature after stirring for 15min, and thus obtaining the plant composite whitening and freckle removing nursing composition.
Preparation example 4
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid and solidago virgaurea extract.
The emulsifier in this preparation is lecithin.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 10Kg of alpha-arbutin, 50Kg of octadecenedioic acid, 4Kg of solidago virgaurea extract and 2Kg of lecithin into an emulsifying pot, stirring at 40 ℃ and 40r/min, cooling to room temperature after stirring for 20min, and thus obtaining the plant composite whitening and freckle removing nursing composition.
Preparation example 5
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid, solidago virgaurea extract and nicotinamide.
The emulsifier in this preparation is octyldodecanol.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 0.5Kg of alpha-arbutin, 1Kg of octadecenedioic acid, 0.2Kg of solidago virgaurea extract, 1Kg of nicotinamide and 0.1Kg of octyldodecanol into an emulsifying pot, stirring at 30 ℃ at a rotation speed of 30r/min for 10min, and cooling to room temperature to obtain the plant composite whitening and freckle removing nursing composition.
Preparation example 6
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid, solidago virgaurea extract and nicotinamide.
The emulsifier in this preparation is octyldodecanol.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 10Kg of alpha-arbutin, 50Kg of octadecenedioic acid, 4Kg of solidago virgaurea extract, 50Kg of nicotinamide and 2Kg of octyldodecanol into an emulsifying pot, stirring at 40 ℃ at a rotating speed of 40r/min, cooling to room temperature after stirring for 20min, and thus obtaining the plant composite whitening and freckle removing nursing composition.
Preparation example 7
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid, solidago virgaurea extract, rosemary leaf extract, ribes nigrum seed oil and peony root extract.
The emulsifier in this preparation is octyldodecanol.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 0.5Kg of alpha-arbutin, 1Kg of octadecenedioic acid, 0.2Kg of solidago virgaurea extract, 0.2Kg of rosemary leaf extract, 0.2Kg of ribes nigrum seed oil, 0.2Kg of peony root extract and 0.1Kg of octyl dodecanol into an emulsification pot, stirring at the temperature of 30 ℃ and the rotation speed of 30r/min for 10min, and cooling to room temperature to obtain the plant composite whitening and freckle removing nursing composition.
Preparation example 8
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid, solidago virgaurea extract, rosemary leaf extract, ribes nigrum seed oil and peony root extract.
The emulsifier in this preparation is octyldodecanol.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 10Kg of alpha-arbutin, 50Kg of octadecenedioic acid, 4Kg of solidago virgaurea extract, 4Kg of myrcia leaf extract, 4Kg of ribes nigrum seed oil, 4Kg of peony root extract and 2Kg of octyldodecanol into an emulsifying pot, stirring at 40 ℃ and 40r/min, cooling to room temperature after stirring for 20min, and thus obtaining the plant composite whitening and freckle removing nursing composition.
Preparation example 9
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid, solidago virgaurea extract, octyl dodecanol oleate and octyl dodecanol stearoyl stearate.
The emulsifier in this preparation is octyldodecanol.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 0.05Kg of octyl dodecanol oleate, 0.05Kg of octyl dodecanol stearoyl-oxy stearate and 0.1Kg of octyl dodecanol into an emulsifying pot, stirring at 60 ℃ and 20r/min of rotation speed, cooling to 30 ℃ after stirring for 10min to obtain a skin-moistening composition, then adding 0.5Kg of alpha-arbutin, 1Kg of octadecenedioic acid and 0.2Kg of solidago virgaurea extract, stirring at 30r/min of rotation speed, cooling to room temperature after stirring for 10min to obtain the plant composite whitening and freckle-removing nursing composition.
Preparation example 10
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid, solidago virgaurea extract, octyl dodecanol oleate and octyl dodecanol stearoyl stearate.
The emulsifier in this preparation is octyldodecanol.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 0.67Kg of octyl dodecanol oleate, 1.33Kg of octyl dodecanol stearoyl-oxy stearate and 2Kg of octyl dodecanol into an emulsifying pot, stirring at 70 ℃ and 30r/min, cooling to 40 ℃ after stirring for 20min to obtain a skin-moistening composition, adding 10Kg of alpha-arbutin, 50Kg of octadecenedioic acid and 4Kg of solidago virgaurea extract, stirring at 40r/min, and cooling to room temperature after stirring for 20min to obtain the plant composite whitening and freckle-removing nursing composition.
Preparation example 11
The preparation example discloses a plant composite whitening and freckle removing nursing composition which is prepared from the following components in parts by weight:
emulsifier, alpha-arbutin, octadecenedioic acid, solidago virgaurea extract, nicotinamide, rosemary leaf extract, ribes nigrum seed oil, peony root extract, octyl dodecanol oleate and octyl dodecanol stearoyloxy stearate.
The emulsifier in this preparation is octyldodecanol.
The preparation method of the plant composite whitening and freckle removing nursing composition comprises the following steps:
adding 0.3Kg of octyl dodecanol oleate, 0.7Kg of octyl dodecanol stearoyl-oxy stearate and 1Kg of octyl dodecanol into an emulsifying pot, stirring at 65 ℃ and the rotation speed of 35r/min, cooling to 35 ℃ after stirring for 15min to obtain a skin-moistening composition, then adding 5Kg of alpha-arbutin, 25Kg of octadecenedioic acid, 25Kg of nicotinamide, 2Kg of solidago virgaurea extract, 2Kg of rosemary leaf extract, 2Kg of ribes nigrum seed oil and 2Kg of salvia miltiorrhiza extract, stirring at the rotation speed of 35r/min, and cooling to room temperature after stirring for 15min to obtain the plant composite whitening and freckle-removing nursing composition.
Comparative example 1
The only difference from preparation example 2 was that the same amount of octyldodecanol was used instead of the α -arbutin, octadecenedioic acid and solidago virgaurea extract.
Comparative example 2
The only difference from preparation example 2 was that only a-arbutin was added to octyldodecanol.
Comparative example 3
The only difference from preparation 2 is that only octadecenedioic acid was added to octyldodecanol.
Comparative example 4
The only difference from preparation example 2 is that only solidago virgaurea extract was added to octyldodecanol.
Comparative example 5
The only difference from preparation example 2 is that α -arbutin and octadecenedioic acid were simultaneously added to octyldodecanol.
Comparative example 6
The only difference from preparation example 2 is that alpha-arbutin and Solidago virginiana extract were added to octyldodecanol at the same time.
Comparative example 7
The only difference from preparation example 2 is that octadecenedioic acid and solidago virgaurea extract were added simultaneously to octyldodecanol.
Application example
Application examples 1 to 18 disclose an emulsion containing a plant composite whitening and freckle removing care composition, which is prepared from a solvent, an emollient, an alcohol humectant, a thickener, a pH regulator, p-hydroxyacetophenone and sodium hyaluronate.
The solvent is water.
The emollient is composed of ethylhexyl palmitate, hydrogenated polyisobutene, liquid paraffin and polydimethylsiloxane.
The alcohol humectant consists of 1, 2-hexanediol, propylene glycol and glycerin.
The stearate surfactant comprises PEG-100 stearate, glyceryl stearate, methyl glucose sesquistearate and PEG-20 methyl glucose sesquistearate.
The thickener comprises xanthan gum and carbomer.
The pH regulator is triethanolamine.
Application example 1 this application example discloses an emulsion containing a plant composite whitening and freckle-removing care composition
The preparation method of the emulsion containing the plant composite whitening and freckle removing nursing composition comprises the following steps:
step 1), adding 69.5Kg of water, 2.4Kg of glycerin, 1.1Kg of propylene glycol, 0.15Kg of xanthan gum, 0.15Kg of carbomer and 0.02Kg of sodium hyaluronate into an emulsifying pot in sequence, heating to 90 ℃ while stirring, rotating at the speed of 35r/min, stirring for 10min, and then preserving heat for 30min to obtain a first mixture.
Step 2), adding 0.7Kg of cetearyl alcohol, 1.9Kg of PEG-100 stearate, glyceryl stearate, 0.3Kg of methyl glucose sesquistearate, 1.8Kg of PEG-20 methyl glucose sesquistearate, 7.3Kg of ethylhexyl palmitate, 3.3Kg of hydrogenated polyisobutene, 6.7Kg of liquid paraffin, and 2.7Kg of polydimethylsiloxane into an oil pan, stirring at 80 ℃ for 20min, and then keeping the temperature for 30min to obtain a second mixture.
Step 3), pumping the second mixture into an emulsifying pot, homogenizing for 3min at a homogenizing speed of 40rpm to obtain a third mixture;
step 4), cooling the third mixture to 65 ℃, adding 0.1Kg of p-hydroxyacetophenone, 0.2Kg of 1, 2-hexanediol and 1.3Kg of propylene glycol, and uniformly stirring at the rotating speed of 30r/min to obtain a fourth mixture;
and 5) cooling the fourth mixture to 40 ℃, adding 0.35Kg of the composition in the preparation example 1, rotating at 25r/min, uniformly stirring, and cooling to 35 ℃ to obtain the emulsion containing the plant composite whitening and freckle removing care composition.
Application example 2 this application example discloses an emulsion containing a plant composite whitening and spot-removing care composition
The preparation method of the emulsion containing the plant composite whitening and freckle removing nursing composition comprises the following steps:
step 1), adding 59.1Kg of water, 7.1Kg of glycerin, 3.3Kg of propylene glycol, 0.05Kg of xanthan gum, 0.05Kg of carbomer and 0.05Kg of sodium hyaluronate into an emulsifying pot in sequence, heating to 90 ℃ while stirring, rotating at the speed of 35r/min, stirring for 10min, and then preserving heat for 30min to obtain a first mixture.
Step 2), adding 0.4Kg of cetearyl alcohol, 0.6Kg of PEG-100 stearate, glyceryl stearate, 0.3Kg of methyl glucose sesquistearate, 0.3Kg of PEG-20 methyl glucose sesquistearate, 3.7Kg of ethylhexyl palmitate, 1.7Kg of hydrogenated polyisobutene, 3.3Kg of liquid paraffin, and 1.3Kg of polydimethylsiloxane into an oil pan, stirring at 80 ℃ for 20min, and then keeping the temperature for 30min to obtain a second mixture.
Step 3), pumping the second mixture into an emulsifying pot, homogenizing for 3min at a homogenizing speed of 40rpm to obtain a third mixture;
step 4), cooling the third mixture to 65 ℃, adding 0.8Kg of p-hydroxyacetophenone, 0.65Kg of 1, 2-hexanediol and 3.9Kg of propylene glycol, and uniformly stirring at the rotating speed of 30r/min to obtain a fourth mixture;
and 5) cooling the fourth mixture to 40 ℃, adding 13Kg of the composition in the preparation example 1, rotating at the speed of 25r/min, uniformly stirring, and cooling to 35 ℃ to obtain the emulsion containing the plant composite whitening and freckle removing care composition.
Application examples 3 to 17 disclose emulsions containing plant composite whitening and freckle removing care compositions
The only difference from application example 2 is that the compositions prepared in preparation examples 3 to 11 and comparative examples 1 to 6 were respectively added to the fourth mixtures prepared in application examples 3 to 17 in step 5) to obtain the emulsions containing the phytocomplex whitening and freckle-removing care compositions in application examples 3 to 17.
Application example 18 this application example discloses a cream containing a plant composite whitening and freckle removing care composition, which is prepared by the following steps:
step 1), adding 57.2Kg of water, 7.1Kg of glycerin, 3.3Kg of propylene glycol, 0.08Kg of xanthan gum, 0.17Kg of carbomer and 0.05Kg of sodium hyaluronate into an emulsifying pot in sequence, heating to 90 ℃ while stirring, rotating at the speed of 35r/min, stirring for 10min, and then preserving heat for 30min to obtain a first mixture.
Step 2), adding 2.1Kg of cetearyl alcohol, 0.6Kg of PEG-100 stearate, glyceryl stearate, 0.3Kg of methyl glucose sesquistearate, 0.6Kg of PEG-20 methyl glucose sesquistearate, 3.7Kg of ethylhexyl palmitate, 1.7Kg of hydrogenated polyisobutene, 3.3Kg of liquid paraffin, and 1.3Kg of polydimethylsiloxane into an oil pan, stirring at 80 ℃ for 20min, and then keeping the temperature for 30min to obtain a second mixture.
Step 3), pumping the second mixture into an emulsifying pot, homogenizing for 3min at a homogenizing speed of 40rpm to obtain a third mixture;
step 4), cooling the third mixture to 65 ℃, adding 0.8Kg of p-hydroxyacetophenone, 0.65Kg of 1, 2-hexanediol and 3.9Kg of propylene glycol, and uniformly stirring at the rotating speed of 30r/min to obtain a fourth mixture;
and 5) cooling the fourth mixture to 40 ℃, adding 13Kg of the composition in the preparation example 11, rotating at the speed of 25r/min, uniformly stirring, and cooling to 35 ℃ to obtain the emulsion containing the plant composite whitening and freckle removing care composition.
Performance test
Test 1 whitening and freckle removing effect test
Selecting volunteers: 39 volunteers with facial color spots of similar status and age of 30-50 years are selected and randomly divided into 13 groups, each group comprises 3, the lotion and cream containing the plant composite whitening and speckle removing care composition prepared by application examples 1-17 are sequentially used for each group, about 0.5g of the composition is smeared after face cleaning in the morning and evening, the size of the composition is about 1 horn coin, and the composition is continuously used for 60 days.
Whitening: the luminance L values of facial skin of volunteers were measured on day 0 and 60 using a CM-700D uv-vis spectrophotometer, and the higher the measured value of L value, the whiter skin was indicated, and the results are expressed as the average of luminance on day 60 minus the L value on day 0, and the detailed data are shown in table 2.
Removing spots: the facial skin of the volunteers was tested using the melanin and hemoglobin test probe (Mexameter MX18) of the multifunctional skin tester MPA9 from CK company, germany, and the facial melanin contents MI of the volunteers were measured on day 0 and day 60, respectively, and the higher the measured value of MI, the higher the melanin content, and the melanin content decreased by subtracting the melanin content on day 0 from the melanin content on day 60, and the detailed data are shown in table 1.
TABLE 1
According to the comparison of the data of application example 16, application example 13 and application example 14 in table 1, the L increase of application example 16 is smaller than that of application example 13 and application example 14, and the melanin decrease of application example 16 is smaller than that of application example 13 and application example 14, which indicates that the simultaneous addition of α -arbutin and octadecenedioic acid having whitening and freckle-removing effects inhibits the whitening and freckle-removing effects from each other, and the comparison of the data of application example 1 and application example 16 indicates that the L increase and melanin decrease of application example 1 are much larger than those of application example 16, which indicates that only the simultaneous addition of α -arbutin, octadecenedioic acid and solidago virgaurea extract in a specific ratio into the composition, although the solidago virgaurea extract has little influence on the whitening and freckle-removing effects, the solidago virgaurea extract relieves the mutual inhibition of α -arbutin and octadecenedioic acid on the whitening and freckle-removing effects from each other, the whitening and freckle-removing effect of the composition is greatly improved, and a breakthrough is made in the whitening and freckle-removing effect of the skin care product, so that the composition with excellent whitening and freckle-removing effects is obtained.
According to the comparison of the data of the application examples 5 and 6 and the application example 1 in the table 1, the increase amount of L and the reduction amount of melanin in the application examples 5 and 6 are both greater than those in the application example 1, which shows that the addition of nicotinamide to the composition further improves the whitening and freckle removing effects of the composition, thereby obtaining the composition with better whitening and freckle removing effects.
According to the comparison of the data of the application examples 7 and 8 and the application example 1 in the table 1, the L increase amount and the melanin reduction amount of the application examples 7 and 8 are larger than those of the application example 1, which shows that the addition of the rosemary leaf extract, the ribes nigrum seed oil and the peony root extract simultaneously breaks through and further improves the freckle removing and whitening effects of the composition under the synergistic cooperation of the rosemary leaf extract, the ribes nigrum seed oil and the peony root extract in a specific ratio, so that the freckle removing and whitening effects of the composition are better.
According to the comparison of the data of the application example 1 and the application examples 2-4 in the table 1, the increase amount of L and the reduction amount of melanin in the application example 1 are both larger than those in the application examples 2-4, which shows that the whitening and freckle removing effect of the composition is better by using the lauryl alcohol as the emulsifier.
Test 2 skin moisturizing Effect test
The moisturizing effect of the emulsion and the cream containing the plant composite whitening and freckle removing care composition prepared in each application example is detected according to QB/T4256-2011 'evaluation guidance for moisturizing efficacy of cosmetics' in light industry standards.
The test method comprises the following steps: the volunteers in test 1 were allowed to rest for 1 hour at a constant temperature (20. + -. 1 ℃ C.) and a relative humidity of 50. + -. 5%. According to (2.0 +/-0.1) mg/cm2The emulsions and creams prepared in application examples 1 to 9 and 17 were applied to the forearm of the volunteer, the inner side was marked with a measurement area, the area of the test area was (3cm x 3cm), the interval between each test area was 1cm, and the skin hydration state was measured 8 hours after the application of the emulsions and creams obtained in the application examples, respectively, and the skin moisturizing effect was expressed by the increase rate of the degree of hydration, and the evaluation results are shown in table 2.
Test 3 anti-inflammatory Effect test
Selecting volunteers: 15 volunteers with similar facial erythema conditions are selected and randomly divided into 5 groups, each group comprises 3 volunteers, each group uses the emulsion and the cream containing the plant composite whitening and freckle removing care composition prepared by application examples 1-9 and 17 respectively, and the emulsion and the cream are applied after face cleaning in the morning and evening, each time is about 0.5g, the size of a coin is about 1 horn, and the use lasts for 60 days. The facial skin of the volunteers was measured by using a heme test probe (Mexameter MX18) of a multifunctional skin tester available from CK corporation, Germany, and the facial erythema dose of each group of volunteers was measured on days 0 and 60, respectively, and the higher the erythema dose value, the more severe the inflammation was, the erythema dose on day 60 was subtracted from the erythema dose on day 0 and divided by the erythema dose on day 0, and the results were expressed as the reduction rate of the erythema dose, and the detailed data are shown in Table 2.
TABLE 2
According to the comparison of the data of the application examples 9 and 10 and the data of the application example 1 in the table 2, the increase rate of the hydration degree and the reduction rate of the erythema amount of the application examples 9 and 10 are both greater than those of the application example 1, which indicates that the octyl dodecanol oleate and the octyl dodecanol stearoyloxy stearate are simultaneously added into the composition and are matched according to a special proportion, so that the composition has a good moisturizing and skin moistening effect after being added into the emulsion, the moisture of the skin is not easy to lose, the skin barrier can be protected, the skin is not easy to be damaged by the outside, the inflammation is reduced, and the skin becomes soft and is not easy to be allergic.
According to the comparison of the data of the application examples 7 and 8 and the data of the application example 1 in the table 2, the decrease amount of the erythema of the application examples 7 and 8 is much larger than that of the application example 1, which shows that the addition of the myrcia extract, the ribes nigrum seed oil and the peony root extract simultaneously leads the composition to be capable of inhibiting the arachidonic acid from generating leukotriene, prostaglandin and the like under the action of lipid oxidase and cyclooxygenase in a special proportion, reduces the inflammation such as redness and swelling, stabbing pain and the like, and leads the nursing composition to have good function of controlling the inflammation.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (8)
1. A plant composite whitening and freckle removing nursing composition is characterized in that: the paint comprises the following components in parts by mass:
0.4-0.6 parts of alpha-arbutin;
1.5-2.5 parts of octadecenedioic acid;
0.15-0.25 part of solidago virgaurea extract;
0.08-0.12 part of emulsifier;
the emulsifier is octyl dodecanol.
2. The plant composite whitening and freckle removing care composition according to claim 1, characterized in that: the paint also comprises the following components in parts by mass:
0.005-0.067 parts of octyl dodecanol oleate;
0.005-0.133 parts of octyl dodecanol stearoyl stearate.
3. The plant composite whitening and freckle removing care composition according to claim 1, characterized in that: the composition also comprises 0.1-5 parts of nicotinamide by mass.
4. The plant composite whitening and freckle-removing care composition according to claim 1 or 2, characterized in that: the composition also comprises the following components in parts by mass:
0.02-0.4 part of rosemary leaf extract;
0.02-0.4 parts of ribes nigrum seed oil;
0.02-0.4 parts of peony root extract.
5. The plant composite whitening and freckle removing care composition according to claim 1, characterized in that: the preparation method of the composition comprises the following steps: adding alpha-arbutin, octadecenedioic acid and solidago virgaurea extract into an emulsifier, stirring at the temperature of 30-40 ℃, rotating at the speed of 30-40 r/min, stirring for 10-20 min, and cooling to room temperature to obtain the plant composite whitening and freckle removing nursing composition.
6. The plant composite whitening and freckle removing care composition according to claim 4, is characterized in that: the preparation method of the composition comprises the following steps: adding 0.01-0.2 part of emollient into an emulsifier, stirring at 60-70 ℃ at the rotating speed of 20-40 r/min, stirring for 10-20 min, cooling to 30-40 ℃ to obtain an emollient mixture, then adding 0.02-0.4 part of rosemary leaf extract, 0.02-0.4 part of ribes nigrum seed oil, 0.02-0.4 part of peony root extract, alpha-arbutin, octadecenedioic acid and solidago virgaurea extract into the emollient mixture, rotating at the rotating speed of 30-40 r/min, stirring for 10-20 min, and cooling to room temperature to obtain the plant composite whitening and freckle removing care composition.
7. An emulsion containing a plant composite whitening and freckle removing nursing composition is characterized in that: the paint comprises the following components in parts by mass:
10-20 parts of an emollient;
5-15 parts of an alcohol humectant;
1.5-4 parts of a stearate surfactant;
0.5-1 part of a thickening agent;
0.02-0.08 part of pH regulator;
0.35-13 parts of plant composite whitening and freckle removing nursing composition according to any one of claims 1-6;
the total mass portion of the solvent added to the emulsion is 100 portions.
8. A cream containing a plant composite whitening and freckle removing nursing composition is characterized in that: the paint comprises the following components in parts by mass:
10-20 parts of an emollient;
5-15 parts of an alcohol humectant;
1.5-4 parts of a stearate surfactant;
1.5-2 parts of a thickening agent;
0.02-0.08 part of pH regulator;
0.35-13 parts of plant composite whitening and freckle removing nursing composition according to any one of claims 1-6;
the total mass portion of the solvent added to the cream is 100 portions.
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