KR101227590B1 - Cosmetic composition comprising for improving acne - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving acne containing red ginseng oil as an active ingredient, it can improve acne by inhibiting the growth of propionibacterium acens ( Propionibacterium acens ) that is the cause of acne.

Description

Cosmetic composition for acne improvement containing red ginseng oil as an active ingredient {COSMETIC COMPOSITION COMPRISING FOR IMPROVING ACNE}

The present invention relates to a cosmetic composition for improving acne containing red ginseng oil as an active ingredient.

Skin is the largest tissue in the body and serves as a primary protective layer against the outside, protecting the inside of the body from stimulation of the external environment, such as changes in outside temperature and humidity, and ultraviolet and harmful substances.

It is reported that such skin abnormalities and troubles can cause psychological anxiety, rejection of social life and mental stress, and deteriorate the quality of life. One of the representative examples is acne.

Acne is a chronic inflammatory disease of the sebaceous glands of the hair follicles. Clinically, acne (pused), pustules, nodules, cysts, etc. occur in the sebaceous face, neck, and chest. This occurs most often during puberty, which is most noticeable.

The exact cause of acne is not known, but various factors are involved and clinical symptoms are caused by the interaction of various factors. The main factors involved in the pathogenesis of acne are sebaceous hyperplasia, abnormal hair follicle keratosis, microbial proliferation and inflammation, and other hormonal or immunological factors. If you do not treat these acne scars may occur, so appropriate treatment is required.

Looking at the mechanism of the development of acne, when androgen is excessively coupled in the hair follicle gland of the acne-prone area, androgenic binding increases to sebaceous gland cell receptors in the hair follicle gland, and sebum stagnated in the hair follicle creates a living environment of the microorganisms to produce propioni Propionibacterium acnes , Staphylococcus epidermidis , and Pityrosporum ovale will grow. These are fat-affinity microorganisms, S. epidermidis is aerobic and grows in the appearance of hair follicles or in the middle of hair follicles, P. acnes are anaerobic and grow inside the hair follicles.

As a method for treating such acne, oral or external preparations are used. However, the use of hormonal agents includes side effects of hormonal abuse, such as inhibition of epidermal growth, the use of antibiotics, side effects such as resistance, pruritus, birth defects, and exfoliants have side effects of skin irritation and contact dermatitis.

Therefore, there is a need for a product development that can alleviate and improve acne as a natural substance that is less irritating to the skin and harmless to the human body.

Accordingly, the present inventors have diligently researched about natural ingredients that can alleviate acne as well as confirm that the red ginseng oil can improve acne by inhibiting the growth of propionibacterium acens , the cause of acne. Based on this, the present invention has been completed.

An object of the present invention is to provide a cosmetic composition for improving acne that can alleviate symptoms as well as acne prevention without skin irritation.

In order to achieve the above object, the present invention provides a cosmetic composition for improving acne containing red ginseng oil as an active ingredient.

The cosmetic composition according to the present invention may exhibit an acne-improving effect because it contains red ginseng oil which effectively inhibits the growth of propionibacterium acens , which is a cause of acne.

Hereinafter, the present invention will be described in more detail.

The cosmetic composition of the present invention contains red ginseng oil as an active ingredient. In this case, the red ginseng oil means an extract obtained through supercritical extraction without the nonpolar solvent soluble extract fraction or co-solvent of red ginseng.

Red ginseng oil according to the present invention can be obtained from red ginseng or red ginseng powder.

At this time, the red ginseng is prepared using a conventional process, and the red ginseng powder is extracted by extracting the extract from the red ginseng obtained by washing with red water ginseng and then dried by hot air drying.

Red ginseng oil of the present invention, red ginseng or red ginseng foil powder according to a conventional method known in the art, can be prepared by a method such as room temperature extraction, warm extraction, ultrasonic extraction, supercritical extraction that is commonly used.

Specifically, a nonpolar solvent is used to effectively extract the vegetable sterols, which are fat soluble components from red ginseng. The nonpolar solvent used in the present invention may be hexane, chloroform, dichloromethane, ethyl acetate, and a mixed solvent thereof. Preferably hexane is used.

This extraction is carried out for 30 minutes to 24 hours at 4 to 70 ℃, preferably from 25 to 65 ℃ for 30 minutes to 2 hours by adding 50 ml to 1 L of a nonpolar solvent to 1 g of red ginseng or red ginseng powder.

In addition, in order to obtain a high extraction yield, extraction in supercritical conditions without cosolvents is possible. Supercritical extraction involves putting red ginseng or red ginseng powder into a supercritical extraction tank, supplying a supercritical fluid (eg, carbon dioxide), and maintaining the pressure in the extraction tank at 300 to 500 bar for 3 to 4 hours at 60 to 80 ° C. To perform. At this time, the supercritical fluid may be one selected from the group consisting of carbon dioxide, nitrogen, nitrous oxide, methane, ethylene, propane and propylene. Preferably carbon dioxide is used.

The red ginseng oil thus obtained is subjected to a purification process if necessary. Such tablets are not particularly limited in the present invention, and known methods are possible. For example, after filtration under reduced pressure, ion exchange resin or silica gel column chromatography is performed.

The red ginseng oil thus prepared includes various components, preferably at least 80% by weight of fats and oils, 0.1-10% by weight of vegetable sterols, 0.1-10% by weight of phospholipids and 0.1-5% by weight. Polyacetylene.

Fats and oils contain saturated and unsaturated fatty acids of C6 ~ C24 as main components. Specifically, the fatty acid may be C14: 1 myristic acid, C14: 0 myristic oleic acid, C15: 0 pentadecanoic acid, C16: 0 palmitic acid, C16: 1 palmitic acid, C17: 0 heptadecanoic acid, C17: 1 cis-10-heptadecenoic acid, C18: 0 stearic acid, C18: 1 oleic acid, C18: 2 linoleic acid, C18: 3 linolenic acid, C20: 0 arachidonic acid, C20: 2 cis-11,14-eicosa Trienoic acid, C21: 0 cis-11-eicosenoic acid, C22: 0 behenic acid, C20: 3 cis-11,14,17-eicosatrienoic acid, C20: 4 arachidonic acid, C22: 1 on Loose acid, C22: 2 cis-13,16-docosadienoic acid, C23: 0 tricosanoic acid, cis-5,8,11,14,17-eicosapentaenoic acid, 24: 0 lignoceric acid , C24: 1 neboronic acid and the like, of which at least 50% consists of linoleic acid.

As a result of evaluating the degree of acne improvement with respect to the red ginseng oil of the present invention prepared as described above, it was effectively inhibited the growth of propionibacterium acens ( propionibacterium acens ) causing acne compared to the water-soluble extract of red ginseng and ethanol extract of red ginseng (experimental) Example 2), it was found that the improvement effect on acne than the triclosan used as a conventional acne treatment agent was more excellent (see Experimental Example 3).

In the composition of the present invention, the content of red ginseng oil is 0.001 to 30% by weight, preferably 0.01 to 10% by weight based on the total weight of the cosmetic composition. When the content of the red ginseng oil is less than the above range, it is difficult to expect the effect of improving acne, and on the contrary, when the content of the red ginseng exceeds the above range, there is no apparent increase in effect due to the increase in content, and discoloration and odor of the product occur. There is a problem that the stability of the formulation is lowered.

Ingredients included in the cosmetic composition of the present invention include ingredients commonly used in cosmetic compositions in addition to red ginseng oil as an active ingredient, and include, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings, and Carrier.

The composition of the present invention may be prepared into any of the formulations conventionally produced in the art and may be formulated into various forms such as solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, Oils, powder foundations, emulsion foundations, wax foundations and sprays, but are not limited thereto. More specifically, it can be manufactured in the form of a softening agent, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters.

[Example]

Hereinafter, preferred embodiments and experimental examples are provided to facilitate understanding of the present invention. However, the following examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited by the examples.

Production Example 1

600 ml of hexane was added to 10 g of red ginseng powder, and refluxed at 65 ° C. for 60 minutes to extract a fat-soluble component. Hexane was removed from the filtrate under reduced pressure to give a dark red ginseng oil.

Production Example 2

Performing the same as in Example 1, using red ginseng powder instead of red ginseng powder to obtain red ginseng oil.

Production Example 3

After putting 1 kg of red ginseng foil into a supercritical extraction tank, the reactor was sealed and liquid carbon dioxide passed through a cooler was introduced into the extraction tank through a conduit at 30 SFC / min. Subsequently, pressure of 450 bar was maintained, and the temperature of the extraction tank was maintained at 75 ° C. to extract for 3 hours to obtain red ginseng oil.

Reference Example 1

20 g of red ginseng powder was added to 1000 ml of purified water, extracted by heating at 80 ° C. for 8 hours in an extractor equipped with a cooling condenser, filtered with 300 mesh filter cloth, left to mature at 10 ° C. for 8 days, and then filtered using Whatman No. 5 filter paper. Filtered. The filtrate was dried with a rotary evaporator at 70 ° C. to obtain a red ginseng aqueous extract.

Reference Example 2

20 g of red ginseng powder was added to 1000 ml of ethanol, extracted by heating at 80 ° C. for 8 hours in an extractor equipped with a cooling condenser, filtered through 300 mesh filter cloth, left to mature at 10 ° C. for 8 days, and then filtered using Whatman 5 filter paper. Filtered. The filtrate was dried with a rotary evaporator at 70 ° C. to obtain a red ginseng ethanol extract.

Examples and Comparative Examples

In order to measure the effect and skin irritation on acne skin of the acne improvement cosmetic composition containing red ginseng oil, nutrient lotion (lotion) was prepared in Examples 1 to 3. Further, Comparative Example 1 was prepared using a lotion containing red ginseng water-soluble extract, Comparative Example 2 a lotion containing red ginseng ethanol extract, and Comparative Example 3 as a lotion containing triclosan as a chemical synthetic antimicrobial agent.

Raw material content
(weight%) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Red ginseng oil of Preparation Example 1 0.25 - - - - - Red ginseng oil of Preparation Example 2 - 0.25 - - - - Red ginseng oil of Preparation Example 3 - - 0.25 - - - Red Ginseng Extract of Reference Example 1 - - - 0.25 - - Red Ginseng Extract of Reference Example 2 - - - 0.25 - Triclosan 0.25 Glyceryl Stearate SE 1.5 1.5 1.5 1.5 1.5 1.5 Stearyl alcohol 1.5 1.5 1.5 1.5 1.5 1.5 lanolin 1.5 1.5 1.5 1.5 1.5 1.5 Polysorbate 1.3 1.3 1.3 1.3 1.3 1.3 Sorbitan stearate 0.5 0.5 0.5 0.5 0.5 0.5 Cured vegetable oil 2.0 2.0 2.0 2.0 2.0 2.0 Mineral oil 5.0 5.0 5.0 5.0 5.0 5.0 Squalane 3.0 3.0 3.0 3.0 3.0 3.0 Trioctan Inn 2.0 2.0 2.0 2.0 2.0 2.0 Dimethicone 0.8 0.8 0.8 0.8 0.8 0.8 Tocopheryl acetate 0.5 0.5 0.5 0.5 0.5 0.5 Carboxyvinyl polymer 0.12 0.12 0.12 0.12 0.12 0.12 glycerin 5.0 5.0 5.0 5.0 5.0 5.0 1,3-butylene glycol 3.0 3.0 3.0 3.0 3.0 3.0 Sodium hyaruronate 5.0 5.0 5.0 5.0 5.0 5.0 Triethanolamine 0.12 0.12 0.12 0.12 0.12 0.12 Incense, preservative, coloring Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Distilled water Balance Balance Balance Balance Balance Balance Sum 100 100 100 100 100 100

Experimental Example 1: red ginseng oil component analysis

Table 2 shows the results of analyzing the components of the red ginseng oil obtained in Preparation Examples 1 to 3 using high performance liquid chromatography (HPLC).

Red ginseng oil composition weight% maintain Vegetable sterols Phospholipids Polyacetylene Etc Production Example 1 81.64 10.08 5.15 0.59 2.54 Production Example 2 81.59 9.62 5.46 0.61 2.72 Production Example 3 78.05 15.09 5.38 0.62 0.86

The results for vegetable sterols and oils and fats in the red ginseng oil are shown in Tables 3 and 4 below. At this time, the composition of ginseng seed oil was measured and described as a reference example (standard deviation ± 0.1).

Vegetable sterol composition weight% Production Example 1
Red ginseng oil Preparation Example 2
Red ginseng oil Production Example 3
Red ginseng oil Ginseng seed oil Campestrol 4.4 3.6 3.61 6.0 Stigmasterol 13.5 12.7 11.04 30.9 β-sitosterol 82.1 83.7 85.35 63.1

Fatty acid composition weight% Production Example 1
Red ginseng oil Preparation Example 2
Red ginseng oil Production Example 3
Red ginseng oil Ginseng seed oil C14: 0 (mylist oleic acid)
C16: 0 (palmite)
C16: 1 (palmitoleic acid)
C18: 0 (stearic acid)
C18: 1 (oleic acid)
C18: 2 (linoleic acid)
C18: 3 (linolenic acid)
trans fat
Etc 0.40
9.50
0.52
1.02
21.18
62.20
5.08
0.52
0.10 0.50
11.10
0.27
1.19
18.21
59.20
4.41
0.52
5.12 1.40
9.04
1.7
1.61
22.00
60.01
2.90
0.33
1.01 -
1.91
0.23
0.32
76.00
15.63
1.66
0.62
4.25 Saturated fatty acid
Unsaturated fatty acids 11.44
88.46 13.06
81.82 13.39
86.61 2.46
93.29

Referring to Tables 3 and 4 above, the content of β-sitosterol in vegetable sterols in red ginseng oil extracted from red ginseng and red ginseng gourd was very high, and the fats and oils contained 81% or more of unsaturated fatty acids. Can be.

Experimental Example 2: Paper Disc Test

In order to confirm the antimicrobial activity against acne bacteria of the red ginseng oil prepared in Preparation Examples 1 to 3, a paper disc test was performed.

First, in order to activate Propionibacterium acnes ATCC 6919, a skin flora of the cause of acne, it was incubated 48 hours ago in BHI liquid medium (Brain-Heart Infusion Broth; 3.7%). The culture medium thus prepared was smeared in 0.1 ml each of BHI solid medium (Brain-Heart Infusion Broth; 3.7%; agar 1.5%) and dried. The red ginseng oil was diluted to 12% (w / v) in a 95% ethanol aqueous solution, and 50 µl each was dropped onto a paper disk having a diameter of 8 mm and placed on a solid medium prepared above. The red ginseng oil was incubated for 3 days in a 35 ° C. anaerobic culture tank. The antimicrobial activity was evaluated by observing the bacterial growth inhibition area around the paper disk and measuring the size of the ring. The results are shown in Table 5 below.

division Size of low ring (mm) Production Example 1 22 Production Example 2 23 Production Example 3 25 Reference Example 1 21 Reference Example 2 21.3

Experimental Example  2: against acne Improvement  Measure

20 females 19 to 26 years of age with acne were used in the same manner as the daily nutritional lotion (lotion) for each of the four weeks to use the nutritional cosmetics of Examples 1-3 and Comparative Examples 1-3. According to the opinion, the degree of improvement was determined according to the following evaluation criteria. The test results are shown in Table 6 below.

<Evaluation Criteria>

+++: Very good improvement.

++: Significant improvement.

+: A slight improvement.

±: No improvement but no deterioration

-: No improvement, rather weakened.

term Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 1 week + + + ± ± + 2 weeks ++ ++ ++ + + ++ 3 weeks ++ ++ +++ + + ++ 4 weeks ++ ++ +++ + + ++

As can be seen in Table 6, the lotion containing red ginseng oil has an improvement effect on acne. Among them, the red ginseng oil of the embodiment has the best improvement on acne, and is a chemical synthetic triclosan. It was found that the improvement effect on acne was better than it contained.

Hereinafter, examples of the formulation of the present invention include a softening lotion, a convergent lotion, a nourishing lotion, a nourishing cream, a massage cream, an essence and a pack, but the formulation of the cosmetic composition of the present invention is not limited thereto.

Formulation Example 1: Softening Longevity (Skin)

As shown in Table 5 below, the flexible longevity containing the red ginseng oil of Preparation Example 3 was prepared according to a conventional method.

ingredient Content (% by weight) Red ginseng oil One glycerin 5 1,3-butylene glycol 3 Betaine One Allantoin 0.1 DL-Panthenol 0.3 EDTA-2Na 0.02 Sodium hyaruronate powder 0.05 ethanol 5 Octyldodec-16 0.2 Polyoxyethylene Cured Castor Oil 0.2 incense Suitable amount antiseptic Suitable amount Pigment Suitable amount Purified water Balance Sum 100

Formulation Example  2: nutrition lotion (lotion)

Nutrients containing red ginseng oil of Preparation Example 1 were prepared according to a conventional method as shown in Table 6 below.

ingredient Content (% by weight) Red ginseng oil 3 Glyceryl Stearate SE 1.5 Cetearyl alcohol 1.0 Sheer butter 1.5 Polysorbate 60 1.3 Sorbitan stearate 0.5 Hardened vegetable oil One Mineral oil 5 Squalane 3 Cyclomethicone 2 Dimethicone 0.8 Tocopheryl acetate 0.5 Carbomer 0.12 glycerin 5 1,3-butylene glycol 3 Sodium hyaruronate powder 0.05 Triethanolamine 0.12 incense Suitable amount antiseptic Suitable amount Pigment Suitable amount Distilled water Balance Sum 100

Formulation Example 3: Nutrition Cream

Nutritional cream containing red ginseng oil of Preparation Example 2 was prepared according to a conventional method as shown in Table 7 below.

ingredient Content (% by weight) Red ginseng oil 3 Lipophilic monostearate 2 Cetearyl alcohol 2 Stearic acid 1.5 Polysorbate 60 1.5 Sorbitan stearate 0.6 Hydrogenated Polyisobutene One Squalane 3 Mineral oil 5 Cyclomethicone 5 Dimethicone One Tocopherol Acetate 0.5 glycerin 5 Betaine 3 Triethanolamine One Xanthan gum 0.05 incense Suitable amount antiseptic Suitable amount Pigment Suitable amount Distilled water Balance Sum 100

Formulation Example 4: Massage Cream

A massage cream containing red ginseng oil of Preparation Example 3 was prepared according to a conventional method as shown in Table 8 below.

ingredient Content (% by weight) Red ginseng oil 3 Pro-type glycerin monostearate 1.5 Cetearyl alcohol 1.5 Stearic acid One Polysorbate 60 1.5 Sorbitan stearate 0.6 Isostearyl Isosterate 5 Squalane 5 Mineral oil 35 Dimethicone 0.5 Hydroxyethylcellulose 0.12 glycerin 6 1,3-butylene glycol 3 Triethanolamine 0.3 incense Suitable amount antiseptic Suitable amount Pigment Suitable amount Distilled water Balance Sum 100

Formulation Example 5: Essence

As shown in Table 9 below, the essence containing the red ginseng oil of Preparation Example 1 was prepared according to a conventional method.

ingredient Content (% by weight) Red ginseng oil 3 glycerin 6 Betaine 5 PEG 1500 2 Allantoin 0.1 DL-Panthenol 0.3 EDTA-2Na 0.02 Hydrogenated Lecithin 0.6 Hydroxyethylcellulose 0.1 Sodium hyaruronate powder 0.08 Carboxyvinyl polymer 0.2 Triethanolamine 0.2 Ceramide 0.2 Octyldodecanol 3 Squalane 3 Polysorbate 60 0.4 Glyceryl Stearate SE 1.5 incense Suitable amount antiseptic Suitable amount Pigment Suitable amount Distilled water Balance Sum 100

Formulation Example 6: Pack

As shown in Table 10 below, a pack containing red ginseng oil of Preparation Example 1 was prepared according to a conventional method.

ingredient Content (% by weight) Red ginseng oil One Polyvinyl alcohol 15 Cellulose sword 0.15 glycerin 3 PEG 1500 2 Betaine 2 DL-Panthenol 0.4 Allantoin 0.1 Triethanolamine 0.2 Nicotinamide 0.5 ethanol 6 PEG 40 hardened castor oil 0.3 incense Suitable amount antiseptic Suitable amount Pigment Suitable amount Distilled water Balance Sum 100

Claims (7)

It is obtained by putting red ginseng or red ginseng gourd into a supercritical extraction tank, supplying a supercritical fluid, and maintaining the pressure of the extraction tank at 300 to 500 bar at 3 to 4 hours at 60 to 80 ° C.
At least 78.05% by weight of the main component consists of fats and oils, 0.1 to 15.09% by weight of vegetable sterols, 0.1 to 10% by weight of red ginseng oil containing 0.1 to 5% by weight of polyacetylene as an active ingredient Cosmetic composition for. delete delete delete According to claim 1, wherein the content of the red ginseng oil is 0.01 to 10% by weight based on the total weight of the cosmetic composition. The composition of claim 1 wherein the composition is a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, pack, essence, emulsion foundation, wax foundation and Cosmetic composition having one formulation selected from the group consisting of a spray. The cosmetic composition according to claim 1, wherein the red ginseng oil contains 82.1 to 85.35% by weight of beta-sterol in 100% by weight of vegetable sterol.