CN112708630A - 用于慢性疼痛的多蛋白酶治疗剂 - Google Patents

用于慢性疼痛的多蛋白酶治疗剂 Download PDF

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Publication number
CN112708630A
CN112708630A CN202011545696.8A CN202011545696A CN112708630A CN 112708630 A CN112708630 A CN 112708630A CN 202011545696 A CN202011545696 A CN 202011545696A CN 112708630 A CN112708630 A CN 112708630A
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ile
leu
lys
ser
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CN202011545696.8A
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Chinese (zh)
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J·O·多利
王佳夫
孟江慧
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Dublin City University
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Dublin City University
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24069Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893Botulinum neurotoxin (3.4.24.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202011545696.8A 2013-12-23 2014-12-19 用于慢性疼痛的多蛋白酶治疗剂 Pending CN112708630A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361920053P 2013-12-23 2013-12-23
US61/920,053 2013-12-23
US14/244,162 US9216210B2 (en) 2013-12-23 2014-04-03 Multiprotease therapeutics for chronic pain
US14/244,162 2014-04-03
CN201480073447.XA CN105916875A (zh) 2013-12-23 2014-12-19 用于慢性疼痛的多蛋白酶治疗剂

Related Parent Applications (1)

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CN201480073447.XA Division CN105916875A (zh) 2013-12-23 2014-12-19 用于慢性疼痛的多蛋白酶治疗剂

Publications (1)

Publication Number Publication Date
CN112708630A true CN112708630A (zh) 2021-04-27

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CN202011545696.8A Pending CN112708630A (zh) 2013-12-23 2014-12-19 用于慢性疼痛的多蛋白酶治疗剂
CN201480073447.XA Pending CN105916875A (zh) 2013-12-23 2014-12-19 用于慢性疼痛的多蛋白酶治疗剂

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US (2) US9216210B2 (enExample)
EP (1) EP3087089B1 (enExample)
JP (1) JP6378772B2 (enExample)
KR (1) KR101900582B1 (enExample)
CN (2) CN112708630A (enExample)
AU (1) AU2014372689B2 (enExample)
CA (1) CA2934986C (enExample)
DK (1) DK3087089T3 (enExample)
ES (1) ES2671493T3 (enExample)
PL (1) PL3087089T3 (enExample)
PT (1) PT3087089T (enExample)
WO (1) WO2015097087A1 (enExample)
ZA (1) ZA201605051B (enExample)

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US11707510B2 (en) * 2018-02-16 2023-07-25 Preclinics Discovery Gmbh Nucleic acid-based botulinum neurotoxin for therapeutic use
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US10457927B2 (en) 2019-10-29
ES2671493T3 (es) 2018-06-06
ZA201605051B (en) 2017-09-27
CN105916875A (zh) 2016-08-31
EP3087089A1 (en) 2016-11-02
DK3087089T3 (en) 2018-06-06
CA2934986A1 (en) 2015-07-02
AU2014372689A1 (en) 2016-07-21
US9216210B2 (en) 2015-12-22
PL3087089T3 (pl) 2018-10-31
US20150174217A1 (en) 2015-06-25
KR20160096201A (ko) 2016-08-12
PT3087089T (pt) 2018-05-28
JP2017501715A (ja) 2017-01-19
WO2015097087A1 (en) 2015-07-02
US20160230159A1 (en) 2016-08-11
KR101900582B1 (ko) 2018-09-19
EP3087089B1 (en) 2018-02-21
CA2934986C (en) 2019-08-20
JP6378772B2 (ja) 2018-08-22
AU2014372689B2 (en) 2018-02-01

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