CN112641898A

CN112641898A - Medicine for quickly losing weight

Info

Publication number: CN112641898A
Application number: CN201911004426.3A
Authority: CN
Inventors: 王忠民
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-10-10
Filing date: 2019-10-10
Publication date: 2021-04-13

Abstract

The invention discloses a medicine for quickly losing weight, which is prepared by taking hawthorn, cassia seed, radish seed, lotus leaf, dried orange peel, tuckahoe, dandelion, coix seed, perilla seed, agastache, amomum fruit, citron fruit, mulberry leaf, microcos paniculata and almond as raw materials according to a certain weight ratio. The medicine can be prepared into any common oral dosage form, has the functions of strengthening spleen and replenishing qi, removing food retention and reducing phlegm, clearing damp and reducing swelling, promoting metabolism and the like, has obvious curative effect on symptoms of weight increase, fat swelling, lipid metabolism abnormality, low immunity, limb weakness and the like caused by simple obesity, and has particularly quick response and no toxic or side effect.

Description

Medicine for quickly losing weight

Technical Field

The invention relates to a medicine for quickly losing weight, in particular to a medicine which is prepared by taking plant traditional Chinese medicines which are both medicine and food as raw materials according to a certain weight ratio and is used for treating a series of discomfort symptoms caused by weight increase.

Background

In recent years, the incidence of obesity is increasing due to unreasonable dietary structure, lack of guarantee of dietary safety and general insufficiency of physical and physical exercise, and physical and psychological hazards caused by obesity cannot be underestimated.

Obesity is a social chronic disease, and is a chronic disease with excessive body fat content, important physical signs, multiple causes and various diseases. The main factors for the formation of the obesity are three, the most common simple obesity accounts for about 95%, and the obesity of the type is divided into constitutional obesity and overeating obesity.

In general, obesity occurs with intrinsic and extrinsic factors. The most common internal factors are genetic factors, 70% of human obesity is related to the genetic factors, and the external factors are neuropsychiatric factors, endocrine factors and the like. The external cause of obesity is most commonly caused by overeating and hypomotility. Obese people have history of diet increase, and are happy with sweet food or eaten during each meal, which causes energy excess. Some patients have too tight working time, which causes insufficient exercise capacity and increases the incidence of obesity. In addition, adverse habits such as smoking, drinking, staying up overnight, etc., can also lead to the development of obesity.

Obesity has a very serious adverse effect on human health. Body Mass Index (BMI) has been reported to have a significant impact on human health. When BMI > 30, the degree of obesity is almost linearly related to the increase in the fatality rate; when the BMI is more than 35, the fatality rate is increased by about 30 to 40 percent; with a BMI > 40, men have a 20 year life expectancy reduction and women have a 5 year reduction.

Obesity increases the incidence of several major diseases. The probability of hypertension and hyperlipidemia is increased due to obesity, and the probability of hypertension is 50% higher for obese people of 40-50 ages than for normal weight; obesity increases the risk of cerebrovascular disease, and cerebral atherosclerosis is likely to occur; obesity increases the risk of type II diabetes, and the incidence rate of long-term obesity patients is 4 times higher than that of common people; the probability of fatty liver, cholecystitis and cholelithiasis is increased for the obese people; the obesity patients have increased probability of coronary heart disease and myocardial infarction; obese persons have increased incidence of osteoarthritis, diabetic osteoarthritis and gouty osteoarthritis; furthermore, obese people have an intrinsic relationship to some cancers, with men increasing the incidence of rectal cancer, prostate cancer, and women increasing the incidence of endometrial, cervical, ovarian, breast, and gallbladder cancers. It follows that obesity has become a rather common disease that seriously jeopardizes the health of the patient.

The weight-reducing medicines commonly used in clinic mainly comprise medicines for inhibiting intestinal digestion and absorption (lipase inhibitors, biguanide medicines, glucoronidase inhibitors and the like), central appetite inhibitors (sibutramine hydrochloride and other central appetite inhibitors) and the like, and the medicines have certain toxic and side effects, and the effect of improving the overall health quality is not very ideal, so the weight-reducing medicines have certain limitation in clinic application.

At present, a special Chinese medicine for reducing weight, which is efficient, safe, quick and free from toxic and side effects, is clinically lacked. The medicine which can effectively prevent the weight from rising, quickly relieve the obesity, is safe, reliable, free from toxic and side effects and can be taken for a long time is researched and developed, and is particularly important for the majority of obesity patients.

The traditional Chinese medicine has the advantages of prevention and treatment of obesity, has less side effects compared with western medicines, is easily accepted by patients, and has reliable overall curative effect. According to the pathogenesis of obesity, the traditional Chinese medicine research is started, and the traditional Chinese medicine variety with the functions of strengthening spleen and replenishing qi, removing food retention and reducing phlegm, clearing damp and reducing swelling, promoting metabolism and the like is mainly selected, so that the traditional Chinese medicine has a good development prospect.

The invention provides a medicament which has reliable curative effect, no toxic or side effect and obvious effect of comprehensively treating obesity, particularly the medicament which is developed by using medicine-food dual-purpose traditional Chinese medicines and has obvious curative effect has the characteristics of safety and effectiveness and very important practical significance, and is also the starting point and the research and development purpose of the inventor. The Chinese patent medicine for quickly losing weight and losing weight is successfully developed, and the blank of the medicine and food dual-purpose Chinese patent medicine for quickly and effectively treating the obesity is filled.

Disclosure of Invention

A medicine for quickly losing weight is mainly used for relieving and lightening a plurality of diseases caused by obesity aiming at the damage of the obesity to the body of a patient, thereby effectively protecting the patient, preventing complications and fundamentally improving the health quality and the life quality of the patient.

The traditional Chinese medicine has certain effect on treating obesity. In ancient times, there were experience and discussion on the treatment of obesity, such as Su Wen & Fa Yi Lun in cloud: "Western people, jin Yu Fang … …, it is in the form of Ling Shu-Yin Yang twenty five people chapter: round face, big head, back shoulder, big abdomen of the earth-shaped man … …, big head, small shoulder, big abdomen of the … … water-shaped man … …. The fat body type, like the paste beam, is bitter in eating and difficult to transport and transform spleen qi, resulting in energy stagnation, which is caused by the disorder of spleen transportation.

Traditional Chinese medicine has unique features in the aspect of recognizing obesity. In order to search for better treatment of obesity and various complications brought by obesity in the future, the inventor carries out various researches and attempts in clinic and searches for a series of effective weight-reducing methods and some important treatment measures. In order to improve the treatment effect of weight loss, inherits and utilizes the traditional theory of traditional Chinese medicine on the cognition and treatment of obesity, carries out systematic observation in multiple subjects by means of modern scientific theory, research technology and exploration method, gives full play to the treatment advantages of traditional Chinese medicine, and tries to find better medicines for reducing obesity and related problems as soon as possible.

The traditional Chinese medicine inheritance studio instructor, Master instructor and Master TCM expert king loyalty in Tianjin have been exploring for many years and believe that the cause of obesity is the dysfunction of viscera, has congenital factors and acquired factors, belongs to the disease root and is mainly the dysfunction of the transportation and transformation of the spleen and stomach. The treatment should be mainly based on regulating viscera and simultaneously considering the target, so as to treat both symptoms and root causes and reduce the body weight to a normal range.

The medicine is realized by the following technical scheme. The medicine for quickly losing weight is characterized by being prepared from the following raw materials in parts by weight by a conventional process of Chinese materia medica pharmaceutics: 10-90 parts of hawthorn, 10-50 parts of semen cassiae, 10-90 parts of radish seeds, 10-60 parts of lotus leaves, 10-60 parts of dried orange peels, 10-90 parts of poria cocos, 10-90 parts of dandelion, 10-60 parts of semen coicis, 10-90 parts of perilla seeds, 10-90 parts of wrinkled gianthyssop, 10-60 parts of fructus amomi, 10-90 parts of citron, 10-90 parts of folium mori, 10-60 parts of microcos paniculata and 10-60 parts of almonds.

The raw material medicaments and the dosage formula are obtained by the inventor through combined clinical tests of many medical institutions for many years, and have obvious curative effect within the dosage range.

A medicine for quickly losing weight is prepared from haw, cassia seed, radish seed, lotus leaf, tangerine peel, tuckahoe, dandelion, coix seed, perilla seed, agastache, amomum fruit, citron fruit, mulberry leaf, microcos paniculata and almond through proportioning, and features synergistic action between functions of said Chinese-medicinal materials, high curative effect, no toxic by-effect and no toxic by-effect

The hawthorn fruit in the medicine for quickly losing weight and losing weight has the functions of removing blood stasis and activating stagnancy, and removing qi and blood, is the essential medicine for losing weight, and has the functions of reducing blood pressure, resisting oxidation, resisting myocardial ischemia, resisting cerebral ischemia and tumors, promoting digestion and metabolism, reducing blood fat and improving blood rheology; the cassia seed has the functions of clearing liver and improving vision, loosening bowel to relieve constipation, has obvious weight-losing effect when being matched with the hawthorn, and has the functions of reducing blood pressure, reducing blood fat, resisting oxidation, resisting aging, resisting free radicals, resisting tumors, enhancing immunity and the like; the radish seed has the effects of promoting digestion, relieving flatulence, descending qi and reducing phlegm, and has the effects of resisting bacteria, resisting hypertension, promoting enterokinesia and the like; the lotus leaves have the functions of promoting hair growth, clearing yang, removing heat, clearing away heart-fire, reducing fat and losing weight, and has the functions of resisting bacteria, viruses, oxidation and the like; the dried orange peel has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm, resisting oxidation, aging, allergy, bacteria and tumor, enhancing immunity and the like, and is a common product for treating phlegm-dampness constitution obesity; the tuckahoe has the effects of strengthening spleen and replenishing qi, promoting diuresis and eliminating phlegm, calming heart and tranquilizing mind, has the effects of resisting aging, resisting tumors, enhancing immunity and the like, and has a good treatment effect on spleen deficiency and phlegm-damp type obesity; the dandelion has the effects of clearing away heat and toxic materials, relieving swelling, resolving hard mass, inducing diuresis, treating stranguria, clearing away liver fire, nourishing kidney and yin, resisting oxidation, aging, fatigue, tumor, bacteria and inflammation, promoting gallbladder function, protecting liver, inducing diuresis, reducing blood sugar and blood fat, enhancing immunity of organism, etc.; the coix seed has the effects of tonifying spleen and lung, clearing heat and removing dampness, eliminating carbuncle and expelling pus, and has the effects of resisting tumors, reducing blood sugar, resisting inflammation and easing pain, regulating lipid metabolism, inhibiting osteoporosis, enhancing immunity and the like; the perilla seed has the effects of relieving exterior syndrome and dispelling cold, promoting qi circulation and regulating stomach, moistening intestines and reducing phlegm, and has the effects of relieving cough and asthma, resisting bacteria and allergy, regulating lipid, resisting arteriosclerosis, reducing blood sugar, resisting aging, resisting tumors, enhancing memory and the like, and clinical researches prove that the oil has the effects of reducing cholesterol, regulating blood fat and losing weight; the ageratum has the effects of aromatizing and eliminating dampness, clearing stomach and eliminating turbid pathogen, regulating qi activity, invigorating spleen and reducing weight, and has the functions of promoting gastrointestinal peristalsis, promoting digestive metabolism, resisting bacteria, fungi, viruses, plasmodium and the like; fructus amomi has the effects of resolving dampness, stimulating appetite, warming spleen, checking diarrhea, regulating qi, preventing miscarriage, relieving distension and fullness, eliminating phlegm, resisting ulcer, checking diarrhea, promoting gastric emptying, enhancing gastrointestinal propulsion, benefiting gallbladder, protecting liver and the like, and is very beneficial to ensuring the normal transportation and transformation functions of the spleen and the stomach; the citron has the effects of regulating qi, lowering adverse qi, relieving chest stuffiness, reducing phlegm, relieving epigastric distention and improving diaphragm, and has the effects of promoting digestion, relieving flatulence, enhancing the functions of spleen and stomach in transportation and transformation; the mulberry leaves have the effects of dispelling wind and heat, clearing lung, moistening dryness, removing liver fire, improving eyesight, resisting blood coagulation, reducing blood fat, reducing cholesterol, resisting thrombus, resisting atherosclerosis, reducing blood sugar, resisting bacteria, inflammation, virus, tumor, aging, fatigue and the like, and can improve intestinal function, relax bowel and lose weight; the microcos paniculata has effects of clearing away heat and toxic materials, eliminating stagnation, invigorating stomach, eliminating dampness, relieving fullness, regulating blood lipid, relieving fever, eliminating jaundice, relieving pain, resisting inflammation, resisting aging, and benefiting digestive system and cardiovascular system; semen Armeniacae amarum has effects of relieving cough, eliminating phlegm, moistening lung, relaxing bowels, nourishing brain, improving intelligence, caring skin, reducing weight, prolonging life, resisting oxidation, resisting tumor, lowering blood pressure, relieving pain, resisting blood coagulation, resisting thrombi, and reducing blood lipid. The composition has good treatment effects of body building, weight losing and the like, and has no toxic or side effect.

A medicine for quickly losing weight has the functions of promoting metabolism, relieving the symptoms caused by obesity and promoting the health of patients. Moreover, the medicines are not the superposition of the effects of single traditional Chinese medicines, but are scientifically prepared on the basis of the treatment based on syndrome differentiation of the traditional Chinese medicine, and the formula effect of 1+1 to more than 2 is realized. The traditional Chinese medicine is mainly characterized by a plurality of efficacies of strengthening spleen and stomach, removing food retention and reducing phlegm, eliminating dampness and reducing swelling, promoting metabolism and the like.

Moreover, the pharmacological actions of the medicines have related pharmacological research or animal test conclusions.

The medicine can be prepared into oral administration dosage forms by adopting a conventional method of Chinese medicine preparations. The medicine of the invention can be prepared by grinding the raw materials into powder and uniformly mixing the powder into powder, granules, oral liquid and beverage. The active ingredients can be obtained by decocting the raw materials in water and then concentrating the decoction, and then the active ingredients can be prepared into various oral preparations, but the invention is not limited by the active ingredients.

The medicine can also be used for extracting effective components by adopting methods such as semi-bionic extraction (SBE), Supercritical Fluid Extraction (SFE), microwave extraction (MAE), enzyme extraction (ETE), ultrasonic extraction (UAE), semi-bionic extraction (SEB), squeezing extraction (PE), Continuous Countercurrent Extraction (CCE), tissue disruption extraction (STE), heating-free extraction (HFE), normal-temperature ultrahigh-pressure extraction (U HPE), Air Explosion Extraction (AEE) and the like, and the extraction methods are all in the protection range of the medicine.

The following capsule formulations are preferred for use in the present invention.

The preparation method of the medicine comprises the following steps:

(1) weighing the raw materials in proportion for later use;

(2) the 15 traditional Chinese medicines of hawthorn, cassia seed, radish seed, lotus leaf, dried orange peel, tuckahoe, dandelion, coix seed, perilla seed, wrinkled gianthyssop herb, villous amomum fruit, citron fruit, mulberry leaf, microcos paniculata and almond in the weight ratio are delivered to a professional traditional Chinese medicine pharmaceutical factory for extraction after being checked and accepted;

(3) extracting by a pharmaceutical factory according to a conventional method and a conventional program for extracting traditional Chinese medicines;

(4) packaging the extracted medicinal powder into bottled capsules, wherein each bottle contains 60 capsules, and each capsule contains 0.45g of the Chinese medicinal extract powder;

(5) or making the extracted medicine into granules, wherein each bag contains 6g of traditional Chinese medicine extraction powder;

(6) the finished product is delivered to clinical trials by the pharmaceutical factory.

The clinical use results show that the medicine of the invention has the following advantages:

1. the invention selects natural edible plant medicines as raw materials, and each component accords with the regulation of a pharmaceutical law and the principle of a traditional Chinese medicine prescription, and highlights the basic characteristics of the combination of traditional Chinese medicine syndrome differentiation and western medicine disease differentiation and the combination of etiology treatment and symptomatic treatment;

2. the medicine of the invention does not need to be decocted after being extracted, has good taste and convenient taking, is nontoxic and harmless before and after the prescription of each medicine, and has no side effect after being taken with normal dosage;

3. the medicine has good treatment effect on obesity and various symptoms caused by obesity, has good prevention and health care effects, and has wide application range;

4. the medicine is selected from the varieties which can be used as both medicine and food and are specified in Weijian Wei, the safety is higher, and the medicine can be taken by patients with obesity in middle-aged and old-aged treatment for a long time;

5. the medicine has good compatibility, and has certain compatibility of treatment on the symptoms such as complication, low immunity, sub-health and the like which are easy to appear in patients;

6. the application range is wide, including the middle-aged and the elderly, the juvenile and other people;

7. the medicine of the invention treats both principal and secondary aspect of disease, and has quick effect.

Detailed Description

The effect of the present invention will be further illustrated by the following examples and clinical application statistics.

Example 1: capsule preparation

15kg of hawthorn, 20kg of cassia seed, 20kg of radish seed, 20kg of lotus leaf, 15kg of dried orange peel, 15kg of poria cocos, 20kg of dandelion, 20kg of coix seed, 15kg of perilla seed, 20kg of wrinkled gianthyssop herb, 12kg of fructus amomi, 18kg of citron, 20kg of mulberry leaf, 15kg of microcos paniculata and 15kg of almond are extracted and processed by a professional Chinese medicine pharmaceutical factory, and are prepared into capsules, wherein each capsule is 0.45g, 4 capsules are taken each time, and 3 times a day.

Example 2: beverage preparation

15kg of hawthorn, 20kg of cassia seed, 20kg of radish seed, 20kg of lotus leaf, 15kg of dried orange peel, 15kg of poria cocos, 20kg of dandelion, 20kg of coix seed, 15kg of perilla seed, 20kg of wrinkled gianthyssop herb, 12kg of fructus amomi, 18kg of citron, 20kg of mulberry leaf, 15kg of microcos paniculata and 15kg of almond are extracted and processed by a professional Chinese medicine pharmaceutical factory, and are prepared into granules, wherein each bag is 6g, 1 bag is taken every time, and 3 times a day, and the granules are taken with water.

Clinical observation of the drug of the invention

One, general data

And (3) observing data: in order to prove the clinical curative effect of the medicine, 146 cases of male and female obese patients are treated by the traditional Chinese medicine outpatient service in 8-2019 and 6-2018, the patients are 18-65 years old and the average (35.2 +/-7.6) years old; 67 of the men and 79 of the women; the observation group and the control group were divided into 73 cases each in 2 groups according to the digital random Chart method. The general clinical data of 2 groups of age, sex, etc. have no significant difference after statistical treatment and are comparable (P > 0.05).

Diagnostic criteria: according to the regulation of the Chinese adult overweight and obese people prevention and control guideline (trial) issued by the department of health in China in 4 months in 2003: the BMI is more than or equal to 24 and is overweight for Chinese adults, the BMI is more than or equal to 28 and is obese, the waist of men is more than or equal to 85cm, and the waist of women is more than or equal to 80cm, and the abdominal fat is accumulated.

Exclusion criteria: under 18 years of age or over 65 years of age; patients with secondary obesity such as cardiovascular diseases, liver and kidney dysfunction, endocrine diseases, and metabolic disorder diseases; women in childbearing age take contraceptive, pregnant or lactating women; patients who did not actively participate in the present clinical treatment, did not sign consent, or participated in other clinical trials.

And (3) inclusion standard: the age is 18-65 years old, and the standard of overweight or obesity inclusion is met; actively cooperate with the treatment, obey the relevant regulations and sign the informed consent.

Second, test method

Comparison medication: the 2 groups are all treated by the drug for 2 months. The observation group takes the medicinal granules of the invention with 6g per bag, 1 bag per time and 3 times per day after being taken with water; the control group orally administered Qumei capsule (Sibutramine hydrochloride capsule, produced by Taiji group Fuling pharmaceutical factory, batch number X031106) 5mg per capsule, 2 capsules per day, 1 time per day, and administered with empty stomach before breakfast in the morning. The two groups are controlled by diet at the same time, so that the thick taste of the fatty and mellow wine is prohibited, foods rich in fiber and vitamins such as vegetables, fruits, coarse grains and the like are eaten in a proper amount, and the exercise amount is properly increased so as to carry out the activities mainly including large-step and quick walking.

The curative effect standard is as follows: refer to the treatment effect evaluation standard of simple obesity established by Chinese and western medicine combined obesity research academic conference in 1998. The recent clinical recovery is as follows: weight loss has reached the standard weight or overweight range; the effect is shown: the weight loss is more than or equal to 5 kg; the method has the following advantages: the weight loss is more than or equal to 3 kg; and (4) invalidation: the weight loss was < 3 kg.

Observation indexes are as follows: 1) observing the effect after treatment; 2) laboratory indexes are as follows: serum Total Cholesterol (TC), serum Triglycerides (TG), serum high density lipoprotein cholesterol (HDL-C), serum low density lipoprotein cholesterol (LDL-C).

Statistical analysis: statistical analysis is carried out by adopting SPSS10.0 for windows statistical software, and Chi is adopted for comparing the curative effects of the two groups²The test shows that P is less than 0.05, which shows that the difference is statistical.

And (3) analyzing the curative effect: (1) the effective rate is compared: after 2 months of treatment, 21 cases (28.77%) of 73 cases in the observation group are clinically cured, 31 cases (42.47%) of significant effect, 17 cases (23.29%) of effective effect, 4 cases (5.48%) of ineffective effect and 94.52% of total effective rate; in 73 cases of the control group, 8 cases (10.96%) are clinically cured, 22 cases (30.14%) are significantly effective, 28 cases (38.36%) are effective, 15 cases (20.55%) are ineffective, and the total effective rate is 79.45%. The clinical cure rate and the significant efficiency of the two groups are compared with the total effective rate, the observed group is superior to the control group, the statistical difference is realized, and P is less than 0.05; (2) test indexes comparison before and after treatment: assay analysis was performed 2 months after treatment. 73 cases of observation group had TC (mmol/L) 6.16. + -. 1.09, TG (mmol/L) 2.73. + -. 0.97, HDL-C (mmol/L) 0.86. + -. 0.34, LDL-C (mmol/L) 4.39. + -. 0.46 before treatment, and after treatment, 4.503. + -. 1.01, 1.17. + -. 1.19, 1.96. + -. 0.57, 2.69. + -. 0.65, respectively; the TC (mmol/L) of the control group is 6.19 +/-1.12, the TG (mmol/L) is 2.76 +/-0.96, the HDL-C (mmol/L) is 0.85 +/-0.36 and the LDL-C (mmol/L) is 4.41 +/-0.45 before treatment, and the TC (mmol/L) is 5.53 +/-1.13, the LDL-C (mmol/L) is 2.22 +/-1.21, the LDL-C (mmol/L) is 1.03 +/-0.46 and the LDL-C (mmol/L) is 3.76 +/-0.59 after treatment respectively. The 2 groups of test indexes before and after treatment have statistical difference, and P is less than 0.05. Clinical researches prove that the medicament has obvious advantages in the aspects of treating obesity and related detection indexes, and has certain popularization value.

Claims

1. The formula of the medicine is characterized in that the medicine is a medicine-food dual-purpose traditional Chinese medicine and is prepared from the following raw material medicines in parts by weight:

2. the medicament for rapidly losing weight and losing weight as claimed in claim 1, wherein the formulation is prepared into capsules by adopting the conventional process of Chinese materia medica pharmaceutics.

3. The medicament for rapidly losing weight and losing weight according to claim 1, which is prepared into tablets by adopting a conventional process of Chinese materia medica pharmaceutics.

4. The medicine for rapidly losing weight and losing weight as claimed in claim 1, wherein the formula is characterized in that the medicine is prepared into powder or granules by adopting the conventional process of Chinese materia medica pharmaceutics.

5. The medicament for rapidly losing weight and losing weight according to claim 1, wherein the medicament is prepared into water pills, honey pills, water honey pills, condensed pills or dripping pills by a conventional process of Chinese materia medica pharmaceutics.

6. The medicine for rapidly losing weight and losing weight as claimed in claim 1, wherein the formula is characterized in that the oral liquid is prepared by adopting the conventional process of Chinese materia medica pharmaceutics.

7. The medicine for rapidly losing weight and losing weight as claimed in claim 1, wherein the formula is characterized in that the medicine is prepared into tea by adopting the conventional process of Chinese materia medica pharmaceutics.