CN113679793A - Lipid-lowering liver-protecting tea and preparation method thereof - Google Patents

Lipid-lowering liver-protecting tea and preparation method thereof Download PDF

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CN113679793A
CN113679793A CN202111000543.XA CN202111000543A CN113679793A CN 113679793 A CN113679793 A CN 113679793A CN 202111000543 A CN202111000543 A CN 202111000543A CN 113679793 A CN113679793 A CN 113679793A
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tea
liver
protecting
lipid
lowering
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李佩芳
李廷荃
杨丽芳
张笑涵
芦文静
任顺平
刘竺华
王振雄
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Shanxi University of Chinese Mediciine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994Coix (Job's tears)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses lipid-lowering liver-protecting tea and a preparation method thereof, wherein the lipid-lowering liver-protecting tea is prepared by taking anser northern tartary buckwheat, raw hawthorn, lotus leaf, Chinese date and coix seed as raw materials and respectively carrying out pretreatment, soaking adsorption and packaging. The lipid-lowering and liver-protecting medicinal tea has good effects of tonifying spleen, excreting dampness, reducing phlegm and removing blood stasis, and from the viewpoint of modern medicine, the liver-protecting and lipid-lowering effects of the traditional Chinese medicine are mainly reflected by inhibiting the absorption of cholesterol, regulating the metabolism of blood fat and promoting the excretion of cholesterol, and meanwhile, the lipid-lowering and liver-protecting tea has the efficacy of protecting liver while assisting in lowering blood fat.

Description

Lipid-lowering liver-protecting tea and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to lipid-lowering liver-protecting tea and a preparation method thereof.
Background
With the increase of life rhythm and working pressure and the continuous change of dietary structure, obesity, hyperlipidemia and fatty liver become epidemic diseases, which brings great trouble to the life of people. According to 2010 global epidemiological survey results, the incidence rate of non-alcoholic fatty liver disease (NAFLD) in adults is up to 20% -33%, while the incidence rate in obese people is up to 75%. The prevalence of the traditional Chinese medicine is increased year by year, the affected people tend to be younger, and the traditional Chinese medicine has no obvious subjective symptoms in the early and middle stages and is ignored by people. However, NAFL is a risk factor for hypertension, diabetic complications, coronary heart disease and obesity, insulin resistance, etc. Wherein, simple non-alcoholic fatty liver disease (NAFL) can be developed into fatty hepatitis (NASH), fatty liver fibrosis, liver cirrhosis and even liver cancer, but the patient often cannot pay enough attention because the patient is often diagnosed in physical examination because of no symptoms. The treatment of NAFLD mainly conditions and regulates diet life at present, saves diet, reduces weight, increases exercise amount and the like in daily life, and eliminates possible causes and inducers; the current medicines for treating the disease comprise an insulin sensitizer, an antioxidant, a lipid-lowering and weight-losing agent, a liver-protecting and anti-inflammatory medicine and the like.
Currently, various liver-protecting drugs and lipid-lowering drugs on the market are unacceptable to many patients due to obvious side effects, such as gastrointestinal reaction, liver metabolism burden increase and the like. Meanwhile, with the coming of aging society, people have stronger and stronger requirements for health preservation and health care. In the face of the clinical phenomenon, a green and safe medicine with obvious curative effect is urgently needed.
The traditional Chinese medicine tea is used for drinking instead of tea, namely the traditional Chinese medicine tea is prepared by matching Chinese herbal medicines with tea leaves, or soaking and decocting the Chinese herbal medicines (single or compound) instead of tea, and then drinking like drinking tea. The traditional Chinese medicine tea substitute drink is a drink prepared by combining selected medicines and tea leaves or (without tea leaves) according to a formula combining syndrome differentiation and disease differentiation under the guidance of the theory of traditional Chinese medicine, method, formula and medicine. At present, the medicinal tea is widely applied to the families of internal, external, women, children, five sense organs and the like, and particularly has outstanding effects in the fields of health preservation and health care and disease rehabilitation.
From the current market, the mainstream herb tea can be roughly divided into health preservation and health care and disease treatment. In terms of variety and functions, the instant tea mainly has the health-preserving and health-care effects of losing weight, reducing blood fat, lowering blood pressure, building body, relieving alcoholism, prolonging life and the like. The composition of the tea is mainly combined with edible medicines and tea leaves, and the tea leaves are often used as substrates, which belongs to the category of typical tea preparations. The health-care tea has great limitation on the selection and the application range of the medicine, the treatment efficacy can be rarely shown, and the development situation is far from meeting the requirement of the modern society on the improvement of the life quality. In addition, most of the lipid-lowering and liver-protecting health products on the market are single-action medicinal tea such as: gynostemma pentaphylla tea, red yeast rice tea, etc. The single medicinal tea has obvious lipid-lowering effect, but has the characteristics of poor taste, cold and cool nature and is not suitable for long-term use.
From a theoretical point of view, a plurality of doctors have conducted research on medicinal tea, and research studies on the medicinal tea include a bin and the like, which show that the fat-regulating and liver-protecting tea (salvia miltiorrhiza, radix puerariae, semen cassiae, hawthorn, semen coicis, chrysanthemum, schisandra chinensis and green tea from Shannan) has the effects of assisting in reducing fat and protecting liver. Clinical trial research on 72 patients with dyslipidemia and abnormal liver function shows that the fat-regulating liver-benefiting tea (hawthorn, pseudo-ginseng, lotus leaf and the like) can effectively assist in regulating blood fat and improving liver function. The lipid-lowering tea has the efficacy of regulating lipid and protecting liver at the same time and is related to the common pathogenesis of the lipid-regulating tea and the liver-protecting tea. The basic pathogenesis of hyperlipidemia and fatty liver is caused by liver dysfunction in smoothing flow of qi, spleen dysfunction in transportation, endogenous dampness and blood stasis and phlegm coagulation. Therefore, the medicinal tea has obvious curative effect on the disease, but the medicine composition selected from the theory of homology of medicine and food is not common to doctors.
Despite the current market, few herbal teas are selected from the theory of homology of medicine and food. The medicinal tea with homology of medicine and food can be obtained by unexpected harvest if the psychological expectation of people that the medicinal tea is convenient to use and carry and can effectively treat diseases is considered to be researched under the guidance of the academic system and the internal thinking of 'preventive treatment of diseases' in the traditional Chinese medicine. The medicinal tea is prepared and dissolved into tea, the tea carries the medicinal property, and the medicinal property and the taste of the tea are determined according to the shape and the characteristics of the tea. Aiming at the blank medical market at present, the lipid-lowering and liver-protecting tea is found to have better curative effects on the aspect of improving symptoms, reducing blood fat and improving the shape and quality of the liver of a patient suffering from phlegm-dampness and blood stasis non-alcoholic fatty liver disease in clinic. And the composition formula of the lipid-lowering liver-protecting tea conforms to the theory of homology of medicine and food, has ideal taste and mild medicine property, is convenient to carry, and is suitable for long-term safe taking. The traditional Chinese medicine theory system of medicinal and edible medicinal tea is actively constructed, the modern pharmaceutical technology and the bioengineering technology are combined, the traditional medicinal tea prescription is repackaged and defined, the ancient method is newly used, and related health products are researched and developed on the basis of the new ancient method, so that the traditional medicinal tea prescription becomes a necessity.
Disclosure of Invention
The invention aims to provide the lipid-lowering liver-protecting tea with definite curative effect and no toxic or side effect and the preparation method thereof.
The technical scheme of the invention is as follows: a lipid-lowering liver-protecting tea is prepared from the following raw materials in parts by weight: 2-5 parts of wild goose northern tartary buckwheat, 9-12 parts of raw hawthorn, 3-10 parts of lotus leaf, 6-15 parts of Chinese date and 10-30 parts of coix seed.
Preferably, 3 parts of wild goose northern tartary buckwheat, 3 parts of raw hawthorn, 1 part of lotus leaf, 5 parts of Chinese date piece and 5g of coix seed.
A preparation method of a lipid-lowering liver-protecting tea comprises the following steps:
a. pre-treatment:
a1, respectively cleaning and placing the bitter goose-north tartary buckwheat and the coix seeds into a frying container, heating with medium fire, frying for 10-15min until the surfaces of the bitter goose-north tartary buckwheat and the coix seeds are yellow for later use;
a2, removing kernels of red dates, slicing the red dates, and then baking the red dates in an oven for 20min until the red dates are all yellow;
a3, crushing the fried anser northern tartary buckwheat, coix seeds and jujube slices by a crusher, wherein the diameter of the crushed particles is 8 meshes;
a4, extracting and concentrating lotus leaves and hawthorn to obtain concentrated solution;
b. soaking and adsorbing: mixing the concentrated solution with pulverized radix Et rhizoma Fagopyri Tatarici, Coicis semen, and fructus Jujubae slice at a ratio of 1:20, and drying in multifunctional medicinal microwave oven at 85 deg.C for 3 hr to obtain medicinal tea granule;
c. packaging: and filling the medicinal tea particles into a corn fiber environment-friendly tea bag to obtain a finished product.
Preferably, the extraction and concentration in the step a4 are carried out by soaking lotus leaves and hawthorn with 92% edible or medicinal ethanol to obtain soft materials, adding the soft materials into a stainless steel pot, adding water into the stainless steel pot, decocting at 100 ℃ for 30min, then carrying out reduced pressure concentration at-0.08 mpa and 50 ℃, and concentrating until the specific gravity is 1.05.
Preferably, the flavoring agent is added after the concentrated solution is prepared in the step a 4.
Preferably, the flavoring agent is fructo-oligosaccharide.
Compared with the prior art, the invention has the beneficial effects that:
1. analysis from composition: the formula is selected based on traditional Chinese medicine books and supported by detailed clinical tests, so that the certainty of curative effects of reducing blood fat, resisting inflammation, protecting liver, regulating immunity and the like can be proved, and the treatment efficacy of the medicinal tea is ensured;
buckwheat: the compendium of materia Medica records: the tartary buckwheat is bitter in taste, slightly cold in nature, capable of tonifying qi, continuing spirit, benefiting ears and eyes, descending qi, widening intestines and invigorating stomach. Modern pharmacological research shows that the tartary buckwheat and the tartary buckwheat product have auxiliary treatment effects on diabetes, hypertension, hyperlipidemia, coronary heart disease and the like.
Hawthorn fruit: the Chinese herbal medicine recorded in Ben Cao Jing Ji Zhu is loaded with Hawthorn fruit, sour and sweet in taste, slightly warm in nature, with the functions of promoting qi circulation, dissipating blood stasis, resolving turbidity and reducing blood fat, and is the essential herb for digesting greasy meat food stagnation, and can be used singly for treating hyperlipidemia in modern clinic.
Coix seed: the records of Shen nong Ben Cao Jing record that Yi ren is sweet in taste and cool in nature, and can invigorate spleen, promote diuresis, eliminate dampness, detoxify and dissipate nodulation.
Lotus leaf: the lotus leaf can resolve dampness and raise clear, and the research proves that the lotus leaf alkaloid substance has the functions of reducing fat and losing weight.
Chinese date: the Chinese dates have sweet and warm nature and taste, have the effects of tonifying middle-jiao and Qi, and can coordinate the drugs in the prescription.
2. The synergistic formula can ensure that the lipid-lowering and liver-protecting medicinal tea has good effects of invigorating spleen, eliminating dampness, reducing phlegm and removing blood stasis. From the viewpoint of modern medicine, the liver-protecting and lipid-lowering effects of traditional Chinese medicines are mainly reflected in inhibiting the absorption of cholesterol, regulating the metabolism of blood lipid and promoting the excretion of cholesterol. The lipid-lowering and liver-protecting tea disclosed by the invention has the effect of protecting the liver while assisting in lowering blood fat.
3. Analysis from the preparation method: the ethanol with better solubility is used as a solvent during extraction, the penetration capacity of the ethanol on Chinese herbal medicine cells is stronger, the dissolved water-soluble impurities are less, the extract of the ethanol is not easy to go moldy and go bad, the traditional decocting technology of the traditional Chinese medicine is combined, the optimal drug effect of the traditional Chinese medicine is ensured, the microwave drying technology is adopted, the functions and properties of the medicinal materials can be ensured, the drying time is short, the heating is uniform, and the green environmental protection concept is met.
4. The invention can avoid various toxic and side effects brought by the current mainstream traditional Chinese and western medicine combination treatment of NAFLD, starts from the perspective of eliminating pathogenic factors and strengthening body resistance of traditional Chinese medicine, takes the ideas of resolving dampness and strengthening spleen, removing stasis and protecting liver, and provides an effective choice for NAFLD treatment.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention. In the drawings:
FIG. 1 is a preparation process of the present invention;
FIG. 2 is a table of the experimental procedures of the present invention;
FIG. 3 is a color ultrasonic examination chart of the tea for reducing blood fat and protecting liver of the present invention in case 1 before taking it;
FIG. 4 is a color ultrasonic examination chart of the blood fat-reducing and liver-protecting tea of the present invention in case 1;
FIG. 5 is a color ultrasonic examination chart of the tea for reducing blood fat and protecting liver in case 2 before taking the tea;
FIG. 6 is a color ultrasonic examination chart of the case 2 after taking the tea for reducing blood fat and protecting liver of the present invention;
FIG. 7 is a color ultrasonic examination chart of the tea for reducing blood fat and protecting liver in case 3 before taking the tea;
FIG. 8 is a color ultrasonic examination chart of the blood fat-reducing and liver-protecting tea of the present invention in case 3;
FIG. 9 is a color ultrasonic examination of example 4 before taking the tea for reducing blood fat and protecting liver;
FIG. 10 is a color ultrasonic examination chart of the blood fat-reducing and liver-protecting tea of the present invention in case 4;
FIG. 11 is a color ultrasonic examination of the blood fat-reducing and liver-protecting tea of the present invention in case 5 before administration;
FIG. 12 is a color ultrasonic examination of the blood fat-reducing and liver-protecting tea of the present invention in case 5;
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
In order to make the technical solutions of the present application better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the embodiments of the present application, and it is obvious that the described embodiments are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
A lipid-lowering liver-protecting tea is prepared from the following raw materials in parts by weight: 2-5 parts of wild goose northern tartary buckwheat, 9-12 parts of raw hawthorn, 3-10 parts of lotus leaf, 6-15 parts of Chinese date and 10-30 parts of coix seed.
Preferably, 3 parts of wild goose northern tartary buckwheat, 3 parts of raw hawthorn, 1 part of lotus leaf, 5 parts of Chinese date piece and 5g of coix seed.
As shown in fig. 1, a preparation method of a lipid-lowering liver-protecting tea comprises the following steps:
a. pre-treatment:
a1, respectively cleaning and placing the bitter goose-north tartary buckwheat and the coix seeds into a frying container, heating with medium fire, frying for 10-15min until the surfaces of the bitter goose-north tartary buckwheat and the coix seeds are yellow for later use;
a2, removing kernels of red dates, slicing the red dates, and then baking the red dates in an oven for 20min until the red dates are all yellow;
a3, crushing the fried anser northern tartary buckwheat, coix seeds and jujube slices by a crusher, wherein the diameter of the crushed particles is 8 meshes;
a4, extracting and concentrating lotus leaves and hawthorn to obtain concentrated solution;
b. soaking and adsorbing: mixing the concentrated solution with pulverized radix Et rhizoma Fagopyri Tatarici, Coicis semen, and fructus Jujubae slice at a ratio of 1:20, and drying in multifunctional medicinal microwave oven at 85 deg.C for 3 hr to obtain medicinal tea granule;
c. packaging: and filling the medicinal tea particles into a corn fiber environment-friendly tea bag to obtain a finished product. Each bag is 18g in size.
The extraction and concentration in the step a4 are carried out by soaking lotus leaves and hawthorn with 92% edible or medicinal ethanol to prepare soft materials, adding the soft materials into a stainless steel pot, adding water into the pot, decocting for 30min at 100 ℃, then carrying out reduced pressure concentration at-0.08 mpa and 50 ℃, and concentrating until the specific gravity is 1.05.
And c, adding a flavoring agent after the concentrated solution is prepared in the step a 4.
The flavoring agent is fructo-oligosaccharide.
And (3) testing: the effects of the inventive substances on the blood lipid level, the liver degree grading, the clinical syndrome integral and the clinical symptom integral of a patient
1. Materials and methods
1.1 medicine: preparing lipid-lowering and liver-protecting tea by taking anser northern tartary buckwheat, raw hawthorn, lotus leaves, Chinese date slices and coix seeds as raw materials, subpackaging into tea bags, and brewing for 15 minutes by using boiled water to prepare crude drugs containing 18g per milliliter;
1.2 dosage: 1 bag per time, 3 times per day;
1.3 subjects: treatment and placebo groups;
as shown in fig. 2, the explicit inclusion criteria are: (ii) patients aged > 18 years and < 75 years; ② the NAFLD Western medicine diagnosis standard is met; and thirdly, the patients who meet the constitution of phlegm-dampness with blood stasis are grouped. The random and control principle is adopted, 60 cases are included, the cases are randomly divided into 2 groups, 30 cases are treated in a treatment group, 30 cases are blank control groups, the treatment period is 12 weeks, and diet adjustment and proper exercise are matched.
1.4 experiment time: 12 weeks;
2. results
2.1 Table 1 statistics and analysis of blood lipid levels were performed on two groups of patients after 12 weeks of treatment. The blood lipid level of two groups of patients after treatment is improved to a certain extent compared with the former blood lipid level, the improvement conditions of TG, CHO and HDL of the treatment groups are obviously better than those of the control group, and P is less than 0.01.
Figure BDA0003235303350000071
Figure BDA0003235303350000081
2.2 Table 2 analysis of grading data of degree of liver under B-ultrasound in two groups of patients, the two groups of patients have statistical difference in grading of degree of liver, P is less than 0.05, namely the degree of improvement of liver in treatment group is better than that of control group, and the medicinal tea is effective on light and medium fatty liver.
Figure BDA0003235303350000082
2.3 Table 3 clinical syndrome score comparison: comparison in group: through the rank-sum test, the difference between the two groups has statistical significance on the total score before and after treatment, and P is less than 0.05. Comparison between groups: through the rank sum test, the difference between the two groups has statistical significance on the comparison of the total score after treatment, and P is less than 0.01, which indicates that the symptom improvement degree of the patients in the treatment group is better than that in the control group after 12 weeks of treatment.
Figure BDA0003235303350000083
2.4 Table 4 statistics of two groups of patients clinical symptoms integration, clinical efficacy determination. The effective rate of the treatment group is 93.3 percent, the control group is 73.3 percent, the effective rate of the treatment group is far higher than that of the control group, and P is less than 0.05.
Figure BDA0003235303350000091
From the data, the lipid-lowering and liver-protecting medicinal tea preparation prepared by the invention has exact clinical curative effect on NAFLD, and can take effect within 12 weeks of a treatment course (short period). Meanwhile, the medicinal and edible medicinal materials used in the invention have less toxic and side effects and are safe to use, thus being suitable for long-term administration of patients.
The invention carries out systematic treatment and clinical observation on 300 patients with different cases, disease conditions, ages and sexes, the total effective rate of treatment is 93.3 percent, and the curative effect is obvious. The effect of the lipid-lowering and liver-protecting herb tea of the present invention is specifically explained below by combining five cases:
case 1
Guo XX, female, 55 years old, with symptoms: discomforts are left in the right upper abdomen, obvious after greasy food is taken, no discomforts are left, the tongue is red, the coating is white, and the pulse is smooth.
The patient entered Shanxi Chinese medicine university Hospital in 6/16/2020 and was subjected to blood test in the spleen and stomach department.
The test report is as follows:
Figure BDA0003235303350000092
Figure BDA0003235303350000101
as shown in fig. 3, simultaneous color ultrasound diagnostic: fatty liver (mild), cystectomy, hepatic cyst.
After a patient drinks the lipid-lowering and liver-protecting medicinal tea for 3 months, the patient undergoes the blood test of the spleen and stomach department within 9 months and 17 days in 2020, and the test report is as follows:
Figure BDA0003235303350000102
as shown in fig. 4, simultaneous color ultrasound diagnostic: hepatic cyst, post-cholecystectomy.
Case 2
Guo X, male, age 39, with symptoms: nausea, aversion to grease, reduced appetite, no discomfort, red tongue with white and thick coating and thready and smooth pulse.
Live in Shanxi Chinese medicine university Hospital 6 months 4 in 2020, through spleen and stomach department.
The test report is as follows:
Figure BDA0003235303350000111
as shown in fig. 5, simultaneous color ultrasound diagnostic: high echo of liver cyst wall, considering polyp possibility, moderate fatty liver, no abnormality of gallbladder, pancreas, spleen and kidney.
After a patient drinks the lipid-lowering and liver-protecting medicinal tea for 3 months, the blood test of the spleen and stomach department is carried out 7 months and 7 days in 2020, and the test report is as follows:
Figure BDA0003235303350000112
as shown in fig. 6, simultaneous color ultrasound diagnostic: high echo of liver cyst wall, considering polyp possibility, mild fatty liver, no abnormality of gallbladder, pancreas, spleen and kidney.
Case 3
History XX, female, 50 years old, symptoms are: there was no obvious discomfort, and the tongue was pale red, white coating and slippery pulse during physical examination.
The patient can live in Shanxi Chinese medicine university Hospital 24 days 3 and 3 in 2020, and is subjected to blood test of the spleen and stomach department.
The test report is as follows:
Figure BDA0003235303350000121
as shown in fig. 7, simultaneous color ultrasound diagnostic: fatty liver (mild).
After a patient drinks the lipid-lowering and liver-protecting medicinal tea for 3 months, the blood test of the spleen and stomach department is carried out in 25 days in 6 months in 2020, and the test report is as follows:
Figure BDA0003235303350000122
Figure BDA0003235303350000131
as shown in fig. 8, simultaneous color ultrasound diagnostic: no obvious abnormality is seen in the gallbladder, pancreas, spleen and kidney.
Case 4
Primitive XX, male, 60 years old, symptoms are: the right upper abdomen is suffocated and uncomfortable, the stool is sticky, the tongue is dark red, the coating is white and thick, the sublingual vein is thick and stasis, and the pulse is smooth when people drink wine or eat greasy food.
The patient should live 30 days at 4 months in 2021 in Shanxi university Hospital, and have blood test of spleen and stomach.
The test report is as follows:
Figure BDA0003235303350000132
as shown in fig. 9, simultaneous color ultrasound diagnostic: fatty liver (moderate), no obvious abnormality of gallbladder, pancreas, spleen and kidney.
After the patients drink the lipid-lowering and liver-protecting medicinal tea for 3 months, the blood test of the spleen and stomach department is carried out in 30 days in 7 months in 2021 years, and the test report is as follows:
Figure BDA0003235303350000133
Figure BDA0003235303350000141
as shown in fig. 10, simultaneous color ultrasound diagnostic: no obvious abnormality is seen in the gallbladder, pancreas, spleen and kidney.
Case 5
Zhang XX, female, age 63, symptoms are: intermittent dull pain in the right upper abdomen, aggravation after fatigue, nausea and vomiting in the morning, proper diet, moderate sleep, thin stool, normal urine, pale tongue, thick and greasy coating, and wiry and smooth pulse.
The patient should live in Shanxi college of traditional Chinese medicine in 2021, 4 months and 6 days, and the blood test of spleen and stomach department is performed.
The test report is as follows:
Figure BDA0003235303350000142
as shown in fig. 11, simultaneous color ultrasound diagnostic: fatty liver (moderate), post cholecystectomy.
After the patients drink the lipid-lowering and liver-protecting medicinal tea for 3 months, the blood test of the spleen and stomach department is carried out 7 months and 7 days in 2021 years, and the test report is as follows:
Figure BDA0003235303350000151
as shown in fig. 12, simultaneous color ultrasound diagnostic: mild fatty liver, post cholecystectomy.
In conclusion, the invention can avoid various toxic and side effects brought by the current mainstream traditional Chinese and western medicine combination therapy of NAFLD, starts from the perspective of eliminating pathogenic factors and strengthening body resistance of traditional Chinese medicines, takes the ideas of resolving dampness and strengthening spleen, removing stasis and protecting liver, and provides an effective choice for NAFLD therapy. The composition selected by the invention is medicinal and edible medicinal materials, has ideal taste, mild medicinal properties, is convenient to carry, is suitable for long-term safe taking, and accords with the characteristic of green therapy of the traditional Chinese medicine. The tea is prepared from the medicinal materials, the medicinal materials are dissolved into the tea, the tea carries the medicinal properties, the medicinal materials follow the shape of the tea, the characteristics of the medicinal materials and the taste of the tea.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement, component separation or combination and the like made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims (6)

1. The lipid-lowering liver-protecting tea is characterized by being prepared from the following raw materials in parts by weight: 2-5 parts of wild goose northern tartary buckwheat, 9-12 parts of raw hawthorn, 3-10 parts of lotus leaf, 6-15 parts of Chinese date and 10-30 parts of coix seed.
2. The lipid-lowering liver-protecting tea as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 3 parts of wild goose northern tartary buckwheat, 3 parts of raw hawthorn, 1 part of lotus leaf, 5 parts of Chinese date piece and 5g of coix seed.
3. The preparation method of the lipid-lowering liver-protecting tea according to claim 1 or 2, characterized by comprising the following steps:
a. pre-treatment:
a1, respectively cleaning and placing the bitter goose-north tartary buckwheat and the coix seeds into a frying container, heating with medium fire, frying for 10-15min until the surfaces of the bitter goose-north tartary buckwheat and the coix seeds are yellow for later use;
a2, removing kernels of red dates, slicing the red dates, and then baking the red dates in an oven for 20min until the red dates are all yellow;
a3, crushing the fried anser northern tartary buckwheat, coix seeds and jujube slices by a crusher, wherein the diameter of the crushed particles is 8 meshes;
a4, extracting and concentrating lotus leaves and hawthorn to obtain concentrated solution;
b. soaking and adsorbing: mixing the concentrated solution with pulverized radix Et rhizoma Fagopyri Tatarici, Coicis semen, and fructus Jujubae slice at a ratio of 1:20, and drying in multifunctional medicinal microwave oven at 85 deg.C for 3 hr to obtain medicinal tea granule;
c. packaging: and filling the medicinal tea particles into a corn fiber environment-friendly tea bag to obtain a finished product.
4. The method for preparing the tea for reducing blood fat and protecting liver according to claim 3, wherein the extracting and concentrating in the step a4 are carried out by soaking the lotus leaves and the hawthorn fruits with 92% edible or medicinal ethanol to prepare soft materials, adding the soft materials into a stainless steel pot, adding water into the stainless steel pot, decocting at 100 ℃ for 30min, then carrying out reduced pressure concentration at-0.08 mpa and 50 ℃, and concentrating to the specific gravity of 1.05.
5. The method for preparing the tea for reducing blood fat and protecting liver according to claim 3, wherein the flavoring agent is added after the concentrated solution is prepared in the step a 4.
6. The preparation method of the tea for reducing blood fat and protecting liver as claimed in claim 5, wherein the flavoring agent is fructo-oligosaccharide.
CN202111000543.XA 2021-08-30 2021-08-30 Lipid-lowering liver-protecting tea and preparation method thereof Pending CN113679793A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105053384A (en) * 2015-07-13 2015-11-18 安徽英华药业有限公司 Barley haw tea and preparation method thereof
CN105709102A (en) * 2016-03-28 2016-06-29 重庆沐雨健康咨询有限公司 Herbaceous plant composition for reducing blood fat

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105053384A (en) * 2015-07-13 2015-11-18 安徽英华药业有限公司 Barley haw tea and preparation method thereof
CN105709102A (en) * 2016-03-28 2016-06-29 重庆沐雨健康咨询有限公司 Herbaceous plant composition for reducing blood fat

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Application publication date: 20211123