CN112641900A

CN112641900A - Medicine for quickly treating child anorexia

Info

Publication number: CN112641900A
Application number: CN201911004512.4A
Authority: CN
Inventors: 王忠民
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-10-10
Filing date: 2019-10-10
Publication date: 2021-04-13

Abstract

The invention discloses a medicament for rapidly treating child anorexia, which is prepared by taking endothelium corneum gigeriae galli, fructus amomi, scorched hawthorn fruit, roasted malt, medicated leaven, radish seed, citron fruit, fingered citron, perilla fruit, orange, Chinese yam and wrinkled gianthyssop herb as raw materials and decocting and extracting the raw materials according to a certain weight ratio. The medicament can be prepared into any common oral dosage form, has the functions of strengthening the spleen and stomach, promoting digestion and removing food retention, promoting development and the like, has obvious curative effect on eliminating anorexia symptoms such as inappetence, anorexia, abdominal distension, development retardation, low immunity and the like caused by various diseases, takes effect particularly quickly, and has no toxic or side effect.

Description

Medicine for quickly treating child anorexia

Technical Field

The invention relates to a medicine for quickly treating child anorexia, in particular to a medicine which is prepared by taking plant traditional Chinese medicines which are both medicine and food as raw materials according to a certain weight ratio and is used for treating a series of uncomfortable symptoms caused by the loss of appetite of children.

Background

Child anorexia is a common pediatric disease. The disease is a non-disease factor, causes symptoms of eating inappetence, inappetence and even food refusal for a long time, is mostly seen in children of 1-6 years old, has the morbidity of 12-34 percent, has the morbidity higher in cities than in rural areas, causes diseases all the year round, and is especially common in late summer and early autumn.

The disease has a certain adverse effect on the growth and development, nutritional status and intelligence development of children patients due to long attack time and insufficient energy intake. Anorexia can not be controlled for a long time, which can lead to the children patients to take insufficient nutrients, is difficult to meet the requirement of rapid growth and development, is easy to cause malnutrition, anemia with different degrees, hypoimmunity, rickets and the like, is easy to cause repeated respiratory tract infection, and further seriously affects the health of the children patients.

Modern medical research considers that child anorexia is related to the deficiency of zinc and protein intake of children. The zinc deficiency can make the cells fallen off from oral mucosa hyperplasia and parakeratosis block the taste bud aperture, so that the food can not directly contact the taste bud, and is difficult to stimulate the taste, thereby generating low appetite and forming anorexia.

At present, a special Chinese medicine for treating child anorexia, which is efficient, safe, quick and free from toxic and side effects, is clinically lacked. The research and development of the medicine which can effectively treat anorexia, promote the normal development of children patients, is safe, reliable, free from toxic and side effects and can be taken for a long time are particularly important for the majority of patients with anorexia.

The traditional Chinese medicine has the advantages of preventing and treating anorexia, has less side effects compared with western medicines, is easy to be accepted by patients and has reliable overall curative effect. According to the pathogenesis of anorexia, the traditional Chinese medicine research is started, and the traditional Chinese medicine variety containing the traditional Chinese medicines for promoting appetite, improving the digestive capacity of spleen and stomach and enhancing immunity is mainly selected, so that the development prospect is good.

The invention provides a medicament with reliable curative effect, no toxic or side effect and remarkable effect of comprehensively treating anorexia, in particular to a medicament which is developed by using medicine-food dual-purpose traditional Chinese medicines and has remarkable curative effect, has the characteristics of safety and effectiveness and very important practical significance, and is also the starting point and the research purpose of the inventor. The successful development of a Chinese patent medicine for quickly treating child anorexia fills the blank that the Chinese patent medicine used as both medicine and food can quickly and effectively treat the anorexia.

Disclosure of Invention

A medicine for quickly treating child anorexia is a therapeutic measure for a group of symptoms of long-term anorexia, dislike of food and influence on development of children. The disease is a chronic digestive dysfunction syndrome, is mainly characterized by dysfunction of spleen and stomach, and is accompanied by symptoms of abdominal fullness and discomfort, emaciation, limb weakness, lusterless complexion, abnormal stool and the like, and then has certain adverse effect on the development of children patients.

The infantile viscera are delicate, fragile and fragile, and the qi and the body are not flushed, which are the yin and yang of the infant. Because the spleen and stomach function is not healthy, and the parents feed the food, the abnormal conditions of hunger and hunger without food preference often occur, and the spleen and stomach are injured in the future. What is not to be neglected is that some parents have problems in education of children, are lovely and sedentary to children, and often the children only honor themselves and have a series of symptoms of liver depression and qi stagnation and liver-stomach disharmony. The traditional Chinese medicine has obvious treatment advantages and has reliable effects on regulating gastrointestinal functions and emotion.

The traditional Chinese medicine considers that children have the characteristics of 'no open wisdom, no self-regulation of diet, hunger and fullness', and if improper diet is adopted or the children eat fat, sweet and greasy food, the dysfunction of the transportation and transformation of the spleen and the stomach is caused; or abnormal appetite may be caused or aggravated by abnormal digestion and nutrition imbalance due to uneven food preference. Clinical observation shows that children eat high-calorie, high-nutrition and unhealthy food frequently, so that digestive dysfunction and abnormal qi and blood circulation are easily caused, and dysfunction of spleen and stomach in ascending the clear and descending the turbid occurs.

After years of exploration, a director of a traditional Chinese medicine inheritance studio and a master TCM teacher like the loyalty of the national institute of medical science in Tianjin consider that the child anorexia is caused by dysfunction of viscera, belongs to the disease root, and once spleen fails to transport and liver qi stagnation is formed, the appetite can be lost. The conventional treatment of infantile anorexia mainly aims at strengthening spleen and stomach, but the inventor thinks that patients with infantile liver-qi stagnation are not rare, and some children can generate qi frequently due to improper education of parents or habit of habit, so that the liver smoothing function is directly or indirectly influenced, liver depression and qi stagnation and spleen qi deficiency are caused, and infantile anorexia is easily formed.

The medicine is realized by the following technical scheme. The medicine for quickly treating the child anorexia is characterized by being prepared from the following raw materials in parts by weight by a conventional process of Chinese materia medica pharmaceutics: 10-90 parts of endothelium corneum gigeriae galli, 10-90 parts of fructus amomi, 10-90 parts of scorched hawthorn fruit, 10-60 parts of roasted malt, 10-60 parts of medicated leaven, 10-90 parts of radish seed, 10-90 parts of citron, 10-60 parts of fingered citron, 10-60 parts of perilla fruit, 10-90 parts of exocarpium citri rubrum, 10-90 parts of Chinese yam and 10-60 parts of wrinkled gianthyssop herb.

The raw material medicaments and the dosage formula are obtained by the inventor through combined clinical tests of many medical institutions for many years, and have obvious curative effect within the dosage range.

A medicine for quickly treating child anorexia is prepared from chicken's gizzard-membrane, amomum fruit, haw, malt, medicated leaven, radish seed, citron, finger citron, perilla fruit, tangerine peel, yam and agastache, and features synergistic action between said Chinese-medicinal components, invigorating spleen and stomach, promoting digestion and development, and eliminating the anorexia caused by different diseases.

The endothelium corneum gigeriae galli in the medicine for quickly treating child anorexia has the effects of invigorating stomach, promoting digestion, arresting seminal emission, stopping enuresis, containing keratin and the like, can promote gastric secretion and gastric acidity to be enhanced, further enhances the motility and emptying capacity of the stomach, is beneficial to digestion, and is one of the most commonly used medicines for treating child indigestion with indigestion and child malnutritional stagnation; fructus Amomi has effects in eliminating dampness, stimulating appetite, warming spleen, relieving diarrhea, regulating qi-flowing, and relieving flatulence, and can be used for treating damp-turbidity obstruction in middle energizer, abdominal distention, anorexia, deficiency-cold of spleen and stomach, emesis, diarrhea, etc.; the scorched hawthorn fruit can enhance appetite, contains a large amount of vitamin C and trace elements, can open the stomach, promote digestion and enhance the immunity of the organism, and particularly has better treatment effect on inappetence caused by meat stagnation; the roasted malt has the effects of tonifying spleen to promote digestion, soothing liver to regulate qi, eliminating abdominal distension, relieving food accumulation and the like in a human body, is particularly suitable for patients with weakness of the spleen and the stomach, can supplement nutrient components in the body, relieve liver qi stagnation, remove chest distress and discomfort of the spleen and the stomach in the aspect of food digestion, and is particularly effective for treating anorexia caused by liver depression and spleen deficiency; the medicated leaven has the effects of resolving food stagnation, eliminating stagnation, invigorating spleen and warming stomach, and has remarkable curative effects on infantile dyspepsia, abdominal distention and inappetence; the radish seed has the effects of promoting digestion, relieving flatulence, descending qi and reducing phlegm, and has good effects on food stagnation, abdominal distending pain, constipation, stagnation and diarrhea, phlegm stagnation and cough and asthma; the citron has the effects of eliminating dampness, warming and activating, regulating qi, reducing phlegm and relieving stasis, and has better curative effects on children patients with abdominal distension, anorexia, thick and greasy tongue body and stuffy breath; the fingered citron has the effects of soothing the liver, strengthening the spleen, reducing phlegm, diminishing swelling, eliminating dampness and stopping vomiting, is suitable for qi-loving children patients, has the effects of treating fullness and distention in chest and abdomen, nausea, vomiting, poor appetite and the like, has high zinc content, and is beneficial to anorexia patients with zinc deficiency; the perilla seeds have the effects of depressing qi and dissolving phlegm, relieving asthma and lubricating intestines, and have better effects on treating anorexia caused by phlegm stagnation and adverse flow of qi, cough and asthma and constipation due to intestinal dryness; the Chinese yam has the effects of tonifying spleen and qi, nourishing yin and promoting diuresis, has the effects of enhancing nerve cell activity, tonifying qi and soothing nerves, nourishing heart and promoting intelligence, enhancing memory function, enhancing digestion and absorption functions of a human body, stimulating appetite and enhancing immunity, and has good curative effects on inappetence, infantile anorexia and dyspepsia; agastache rugosus has the effects of eliminating turbid pathogen with aromatics, regulating the middle warmer and relieving vomiting, relieving exterior syndrome and relieving summer-heat, and has good effects on epigastric fullness and vomiting, fever and lassitude, chest distress and discomfort, cold-dampness and summer-heat retention, abdominal pain and vomiting and diarrhea, thick and greasy tongue coating and the like caused by damp-turbidity and middle obstruction.

A Chinese medicine for quickly treating the anorexia of children is prepared from the Chinese-medicinal materials including liquorice root, etc. Moreover, the medicines are not the superposition of the effects of single traditional Chinese medicines, but are scientifically prepared on the basis of the treatment based on syndrome differentiation of the traditional Chinese medicine, and the formula effect of 1+1 to more than 2 is realized. The traditional Chinese medicine is mainly embodied in a plurality of efficacies of strengthening spleen and replenishing qi, regulating qi and harmonizing stomach, promoting digestion and the like.

Moreover, the pharmacological actions of the medicines have related pharmacological research or animal test conclusions.

The medicine can be prepared into oral administration dosage forms by adopting a conventional method of Chinese medicine preparations. The medicine of the invention can be prepared by grinding the raw materials into powder and uniformly mixing the powder into powder, granules, oral liquid and beverage. The raw materials can be decocted in water and then concentrated into decoction to obtain effective components, and then the effective components are prepared into various oral preparations, but the invention is not limited by the protection scope of the invention.

The medicine can also be used for extracting effective components by adopting methods such as semi-bionic extraction (SBE), Supercritical Fluid Extraction (SFE), microwave extraction (MAE), enzyme extraction (ETE), ultrasonic extraction (UAE), semi-bionic extraction (SEB), squeezing extraction (PE), Continuous Countercurrent Extraction (CCE), tissue disruption extraction (STE), heating-free extraction (HFE), normal-temperature ultrahigh-pressure extraction (U HPE), Air Explosion Extraction (AEE) and the like, and the extraction methods are all in the protection range of the medicine.

The following capsule formulations are preferred for use in the present invention.

The preparation method of the medicine comprises the following steps:

(1) weighing the raw materials in proportion for later use;

(2) checking and accepting 12 traditional Chinese medicines of the endothelium corneum gigeriae galli, the fructus amomi, the scorched hawthorn fruit, the fried malt, the medicated leaven, the radish seed, the citron fruit, the fingered citron fruit, the perilla fruit, the exocarpium citri rubrum, the Chinese yam and the agastache rugosus according to the weight ratio, and delivering the qualified traditional Chinese medicines to a professional traditional Chinese medicine pharmaceutical factory for extraction;

(3) extracting by a pharmaceutical factory according to a conventional method and a conventional program for extracting traditional Chinese medicines;

(4) packaging the extracted medicinal powder into bottled capsules, wherein each bottle contains 60 capsules, and each capsule contains 0.45g of the Chinese medicinal extract powder;

(5) or making the extracted medicine into granules, wherein each bag contains 6g of traditional Chinese medicine extraction powder;

(6) the finished product is delivered to clinical trials by the pharmaceutical factory.

The clinical use results show that the medicine of the invention has the following advantages:

1. the invention selects natural edible plant medicines as raw materials, and each component accords with the regulation of a pharmaceutical law and the principle of a traditional Chinese medicine prescription, and highlights the basic characteristics of the combination of traditional Chinese medicine syndrome differentiation and western medicine disease differentiation and the combination of etiology treatment and symptomatic treatment;

2. the medicine of the invention does not need to be decocted after being extracted, has good taste and convenient taking, is nontoxic and harmless before and after the prescription of each medicine, and has no side effect after being taken with normal dosage;

3. the medicine has good treatment effect on child anorexia and various symptoms, has good prevention and health care effects, and has wide application range;

4. the medicine is selected from the varieties which can be used as both medicine and food and specified in Weijian Wei, has higher safety, and can be taken by children anorexia patients for a long time;

5. the medicine has good compatibility, and has certain compatibility treatment effect on symptoms such as complications, low immunity, susceptibility, sub-health state and the like which are easy to appear in children with anorexia;

6. the medicine of the invention treats both principal and secondary aspect of disease, and has quick effect.

Detailed Description

The effect of the present invention will be further illustrated by the following examples and clinical application statistics.

Example 1: capsule preparation

15kg of endothelium corneum gigeriae galli, 12kg of fructus amomi, 20kg of scorched hawthorn fruit, 20kg of fried malt, 15kg of medicated leaven, 15kg of radish seed, 18kg of citron, 15kg of fingered citron, 15kg of perilla fruit, 15kg of exocarpium citri rubrum, 20kg of Chinese yam and 15kg of wrinkled gianthyssop herb are extracted and processed by a professional Chinese medicine pharmacy factory, and are prepared into capsules, wherein each capsule is 0.45g, the dose is determined according to different age groups after 3 times a day.

Example 2: beverage preparation

15kg of endothelium corneum gigeriae galli, 12kg of fructus amomi, 20kg of scorched hawthorn fruit, 20kg of fried malt, 15kg of medicated leaven, 15kg of radish seed, 18kg of citron, 15kg of fingered citron, 15kg of perilla fruit, 15kg of exocarpium citri rubrum, 20kg of Chinese yam and 15kg of wrinkled gianthyssop herb are extracted and processed by a professional Chinese medicine pharmacy factory, are prepared into granules, 6g of the granules are packaged in each bag, 3 times a day, and the taking dosage is determined according to different age groups.

Clinical observation of the drug of the invention

One, general data

In order to prove the clinical curative effect of the medicine for treating child anorexia, in 5-4 2019 in 2018, the inventor treats 122 male and female anorexia patients with age of 1.1-7 years in a traditional Chinese medicine gynecologic outpatient service in a Hospital of Hospital; 71 men and 51 women; the shortest disease course is 6 months, and the longest disease course is 6 months in 2 years; the observed group and the control group were divided into 61 cases according to the digital random Chart method. The general clinical data of two groups of age, sex, height, weight, course of disease, severity of illness, etc. have no significant difference after statistical treatment and are comparable (P is more than 0.05).

Diagnostic criteria: is determined according to the anorexia diagnosis standard in the Chinese traditional medicine disease diagnosis curative effect standard issued in 1994. Patients with chronic inappetence without other diseases; lusterless complexion, emaciation, but good spirit and no abdominal distension; there is a history of improper feeding, such as untimely and quantitative feeding, overeating raw or cold food, sweet and thick taste, food preference or snacks.

Exclusion criteria: eliminating organic diseases of digestive system such as peptic ulcer and hepatitis, and anorexia caused by systemic diseases such as uremia and hypothyroidism.

And (3) inclusion standard: the children are aged 1-7 years and accord with the diagnosis standard of infantile anorexia, parents actively cooperate with medication, the children take medicines smoothly, and the children sign a voluntary agreement to add in a clinical observation.

Second, test method

Comparison medication: the observation group takes 6g of medicinal granules for quickly treating the child anorexia. 1/2 bags are taken for children 1 year old or under the year old every time, 1 bag is taken for children 2-3 years old every time, 1.5 bags are taken for children 3 years old or over, and the bags are taken for 3 times/d after being boiled with water; oral liquid for invigorating spleen and resolving food stagnation for children (Guilin Yibai Lijiang pharmacy Co., Ltd., its ingredients are Ginseng radix, radix astragali, Atractylodis rhizoma, Poria, rhizoma Polygonati, fructus crataegi preparata, fructus Hordei Germinatus, Massa Medicata Fermentata, fructus oryzae, endothelium corneum Gigeriae Galli, Raphani semen, herba Lycopodii, and semen Alpiniae Katsumadai), and its application and dosage are as follows: 4-5 mL for children 1 year old or under, 5-10 mL for children 2-3 years old, 10mL for children 3 years old or over, 2 times/d. All 2 groups were treated continuously for 2 months.

Observation indexes are as follows: the primary and secondary symptoms of the infant before and after treatment were graded and quantified and the efficacy was assessed. 1) The symptom grading standard is drawn up according to a method for grading the anorexia of the young children in the guideline of clinical research on new Chinese medicines, the main symptoms are no, light, medium and heavy, and the scores are 0, 3, 5 and 7; the secondary symptoms are none, light, medium and heavy, and the scores are 0, 1, 2 and 3. 2) Measuring the height and weight of the infant before and after treatment. 3) And (4) measuring the Zn content in the blood serum of the infant before and after treatment.

The curative effect standard is as follows: is determined according to the relevant standards of the clinical research guiding principles of new traditional Chinese medicines. The appetite and the appetite are recovered to normal level, the symptoms and physical signs disappear or basically disappear, and the syndrome score is reduced by more than or equal to 95 percent to cure; the appetite is obviously recovered, the appetite is recovered to 3/4 of the original level, and the reduction of the syndrome integral is more than or equal to 70 percent, so that the effect is obvious; the appetite is improved, the appetite is recovered to some extent, but the appetite does not reach 3/4 of the original level, and the reduction of the syndrome score by more than or equal to 30 percent is effective; the appetite and food intake are not improved, and the reduction of the syndrome integral by less than 30 percent is ineffective. The calculation formula adopts a nimodipine method: the combined efficacy index is (pre-treatment integral-post-treatment integral)/pre-treatment integral x 100%.

Statistical analysis: statistical analysis is carried out by adopting SPSS16.0 statistical software, t test is adopted for comparison among the measurement data groups, Ridit test is adopted for the grade data, and data are used

And (4) showing. P < 0.05 is statistically different.

And (3) analyzing the curative effect: 1) the effective rates of the two groups are compared. 44 cases (72.1%) are cured in 61 cases of the observation group, 12 cases (19.7%) are effective, 4 cases (6.6%) are effective, 1 case (1.6%) is ineffective, and the total effective rate is 98.4%; in 61 cases of the control group, 26 cases (42.6%) are cured, 12 cases (19.7%) with obvious effect, 9 cases (14.7) with effect, 14 cases (22.9%) with no effect and 77.1% of total effective rate. 2) Height was compared to weight change. The height (cm) of 61 cases in the observation group is 98.5 +/-15.2 before treatment and 99.9 +/-16.7 after treatment; 61 cases in the control group had 98.4 + -16.1 of height before treatment and 99.3 + -17.1 after treatment. The weight (kg) of 61 cases in the observation group before treatment is 14.1 +/-4.2, and the weight (kg) of 61 cases after treatment is 15.3 +/-4.7; control 61 cases 13.9 + -4.0, 14.9 + -4.5 after treatment. 3) Two groups of serum Zn changes. The observation group has 61 cases with 7.12 plus or minus 2.16 before treatment and 9.51 plus or minus 2.31 after treatment; 61 cases in the control group had 7.09. + -. 1.97 before treatment and 8.39. + -. 2.21 after treatment. The data show that the medicine for quickly treating the child anorexia has obvious advantages, the recovery is realized, the total effective rate is changed, the height and the weight are changed, and the P is less than 0.05 before and after the treatment of the serum Zn change, so that the medicine has a certain clinical popularization value.

Claims

1. The formula of the medicine is characterized in that the medicine is a medicine-food dual-purpose traditional Chinese medicine formula and is prepared from the following raw material medicines in parts by weight:

2. the medicament for rapidly treating child anorexia according to claim 1, wherein the formulation is prepared into capsules by a conventional process of Chinese materia medica pharmaceutics.

3. The medicament for rapidly treating child anorexia according to claim 1, wherein the formulation is prepared into tablets by a conventional process of Chinese materia medica preparation.

4. The medicine for rapidly treating child anorexia according to claim 1, wherein the formulation is prepared into powder or granules by a conventional process of Chinese materia medica preparation.

5. The medicament for rapidly treating child anorexia as claimed in claim 1, wherein the formulation is prepared into water pill, honey pill, water-honey pill, concentrated pill or drop pill by conventional process of Chinese materia medica pharmaceutics.

6. The medicine for rapidly treating child anorexia according to claim 1, wherein the formula is that the oral liquid is prepared by a conventional process of Chinese materia medica pharmaceutics.

7. The medicine for rapidly treating child anorexia according to claim 1, wherein the formula is prepared into tea by a conventional process of Chinese materia medica pharmaceutics.