CN112641881A - Chinese herbal medicine ointment for treating leukoplakia vulvae - Google Patents
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Abstract
The invention discloses a Chinese herbal medicine paste for treating leukoplakia vulvae, which comprises the following components in parts by weight: 5-20g of safflower, 5-20g of glossy privet fruit, 5-20g of Chinese angelica, 5-20g of fleece-flower root, 10-25g of malaytea scurfpea fruit, 30g of borneol, 5-25g of garden balsam stem, 5-20g of rhizoma polygonati, 10-25g of angelica dahurica, 3-5 centipedes, 3-15g of scorpion, 1200g of medical vaseline 800-; the traditional Chinese medicine superfine powder is prepared from safflower, glossy privet fruit, Chinese angelica, tuber fleeceflower root, malaytea scurfpea fruit, borneol, garden balsam stem, rhizoma polygonati, angelica dahurica, centipede and scorpion by a superfine grinding technology. The Chinese herbal medicine ointment adopts an ultramicro crushing technology, improves the curative effect of the ointment, reduces the dosage, reduces the cost and is beneficial to industrial development.
Description
Technical Field
The invention relates to a Chinese herbal medicine paste, in particular to a Chinese herbal medicine paste for treating leukoplakia vulvae.
Background
Leukoplakia vulvae (leukoplakia vulvae) is a common gynecological disease, and the main clinical manifestations of leukoplakia vulvae are as follows: progressively aggravated pruritus vulvae, local skin mucosa hypopigmentation, roughness, lichen-like changes or atrophy, seriously affecting the physical and mental health and quality of life of the patient. The leukoplakia vulvae can be divided into three types according to the tissue and pathology, namely hyperplasia type, hard-withering type and mixed type. At present, the treatment of leukoplakia vulvae lacks of special methods and medicines, and is one of the difficulties of gynecological clinical treatment. Also, the disease has been considered as a precancerous lesion of the vulva, with the potential for carcinogenesis in atypical hyperplasias.
The etiology and pathogenesis of leukoplakia vulvae are unknown, and western medicine considers that the leukoplakia vulvae is related to local inflammation or non-inflammatory stimulation, genetic factors, autoimmunity, systemic and local hormonal changes. The traditional Chinese medicine belongs to the category of pruritus vulvae, has a set of relatively mature and complete theory for the occurrence of the disease, and distinguishes the disease into three symptoms of liver and kidney deficiency, spleen and kidney yang deficiency and damp-heat accumulation. The treatment aspect is lack of a mature and effective method so far, so that the disease becomes one of the difficulties of gynecological treatment.
Western medicine adopts comprehensive therapy such as medicine, physical therapy and surgical therapy, and has poor curative effect and easy recurrence. Many of these approaches are remedied by pain that patients cannot accept or tolerate the treatment. The traditional Chinese medicine adopts syndrome differentiation treatment, the curative effect varies from person to person, the change is large, the individual principle is followed, and the special patent medicine is lacked, so the clinical application of the traditional Chinese medicine is limited.
Disclosure of Invention
The invention aims to provide a Chinese herbal medicine paste for treating leukoplakia vulvae, which can be used as a Chinese herbal medicine paste for treating leukoplakia vulvae and has improved cure rate.
In order to achieve the aim, the invention provides a Chinese herbal medicine paste for treating leukoplakia vulvae, which comprises the following components in parts by weight: 5-20g of safflower, 5-20g of glossy privet fruit, 5-20g of Chinese angelica, 5-20g of fleece-flower root, 10-25g of malaytea scurfpea fruit, 30g of borneol, 5-25g of garden balsam stem, 5-20g of rhizoma polygonati, 10-25g of angelica dahurica, 3-5 centipedes, 3-15g of scorpion, 1200g of medical vaseline 800-; the traditional Chinese medicine superfine powder is prepared from safflower, glossy privet fruit, Chinese angelica, tuber fleeceflower root, malaytea scurfpea fruit, borneol, garden balsam stem, rhizoma polygonati, angelica dahurica, centipede and scorpion by a superfine grinding technology.
Preferably, the pH value of the Chinese herbal medicine paste is 7-7.4.
Preferably, the Chinese herbal medicine paste comprises the following components in parts by weight: 10g of safflower, 10g of glossy privet fruit, 10g of Chinese angelica, 10g of tuber fleeceflower root, 15g of malaytea scurfpea fruit, 30g of borneol, 15g of garden balsam stem, 10g of rhizoma polygonati, 15g of angelica dahurica, 3 centipedes, 7g of scorpion, 1000g of medical vaseline, 250g of medical glycerin and 150g of edible white vinegar.
The invention also aims to provide a preparation method of the Chinese herbal medicine paste for treating leukoplakia vulvae, which comprises the following steps: 5-20g of safflower, 5-20g of glossy privet fruit, 5-20g of angelica, 5-20g of fleece-flower root, 10-25g of fructus psoraleae, 30g of borneol, 5-25g of garden balsam stem, 5-20g of rhizoma polygonati, 10-25g of angelica dahurica, 3-5 centipedes and 3-15g of scorpion are dried, sterilized by ultraviolet rays, coarsely crushed and processed, and then the mixture is prepared into traditional Chinese medicine superfine powder by a superfine crushing technology; 1200g of medical vaseline-.
The Chinese herbal medicine paste for treating leukoplakia vulvae has the following advantages:
the Chinese herbal medicine ointment for treating leukoplakia vulvae provided by the invention has the advantages that the stability and the texture of the ointment are obviously improved, the curative effect of the ointment is improved, the dosage is reduced, the cost is reduced and the industrial development is facilitated by adopting an ultramicro crushing technology.
The invention can crush the Chinese herbal medicine solid substances into superfine powder with the diameter less than 10 mu m by a superfine crushing technology, and the superfine crushed powder has good dissolubility, dispersibility and adsorbability, can greatly improve the release and absorption of the active ingredients in the medicinal materials in vivo and improve the efficacy of the Chinese medicinal preparation.
The Chinese herbal medicine ointment for treating leukoplakia vulvae improves the dissolution rate and the bioavailability of the traditional Chinese medicine, enhances the efficacy of the traditional Chinese medicine, reduces the dosage, saves raw materials, improves the efficiency and reduces the cost. Moreover, the Chinese herbal medicine paste for treating leukoplakia vulvae has the advantages of uniform effective components of the Chinese herbal medicines, fine and smooth texture and convenient application.
Drawings
FIG. 1 shows the biopsy results of the pathological tissues before treatment in Experimental example 3 of the present invention.
FIG. 2 shows the biopsy results of the pathological tissues after the treatment in Experimental example 3 of the present invention.
Fig. 3 is a real image of the Chinese herbal medicine paste for treating leukoplakia vulvae prepared in example 1 of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A Chinese herbal medicine paste for treating leukoplakia vulvae comprises the following components in parts by weight: 10g of safflower, 10g of glossy privet fruit, 10g of Chinese angelica, 10g of tuber fleeceflower root, 15g of malaytea scurfpea fruit, 30g of borneol, 15g of garden balsam stem, 10g of rhizoma polygonati, 15g of angelica dahurica, 3 centipedes, 7g of scorpion, 1000g of medical vaseline, 250g of medical glycerin and 150g of edible white vinegar, and the preparation method comprises the following steps:
(1) 5-20g of safflower, 5-20g of glossy privet fruit, 5-20g of angelica, 5-20g of fleece-flower root, 10-25g of fructus psoraleae, 30g of borneol, 5-25g of garden balsam stem, 5-20g of rhizoma polygonati, 10-25g of angelica dahurica, 3-5 centipedes and 3-15g of scorpion are dried, sterilized by ultraviolet rays, coarsely crushed and processed, and then the mixture is prepared into traditional Chinese medicine superfine powder by a superfine crushing technology;
(2) 1200g of medical vaseline-.
Experimental example 1 physical and chemical Properties of Chinese herbal medicine paste
The physical and chemical properties of the Chinese herbal medicine paste prepared in example 1 were tested, and the results were as follows:
(1) the Chinese herbal paste prepared in example 1 was not examined for particles larger than 10 μm by particle size and particle size distribution measurement (appendix IX E first method) specified in the Chinese pharmacopoeia 2005 edition.
(2) The Chinese herbal medicine paste prepared in the embodiment 1 is semisolid in appearance, uniform and consistent in color, free of dirt, fine and smooth in texture and smooth.
(3) The Chinese herbal medicine paste prepared in example 1 was heated in a water bath, and the water bath temperature was 53 to 56 ℃ when the paste was melted from a semisolid state.
(4) And (3) measuring the pH value of the Chinese herbal medicine paste prepared in the example 1, melting a small amount of the paste, naturally cooling the paste to be in a semi-solid state, and detecting the paste by using pH test paper to obtain the pH value of the paste of 7-7.4.
(5) The stability of the Chinese herbal medicine paste prepared in the example 1 is measured, and the physical and chemical properties of the paste, such as appearance, texture, pH value and the like, are not changed after the paste is placed at room temperature for 1, 2, 3, 6, 9 and 12 months, which shows that the paste has stable property and can be stored at room temperature for a long time.
(6) The Chinese herbal medicine ointment prepared in the example 1 is applied to the normal skin on the inner side of the forearm in a proper amount, and after 72 hours, the skin where the ointment is applied does not have any abnormality such as itching, redness, blisters, congestion or maculopapule and the like. The ointment has good adhesion to skin, and is easy to clean.
Experimental example 2 Observation of therapeutic Effect
The vulva is cleaned by clear water, and after being wiped dry, a proper amount of ointment is applied to the affected part 1-2 times a day except for the menstrual period. One month is a treatment course, and the medicine is continuously used for 3-4 treatment courses. The spicy food needs to be eaten less during the use period and after the cure, the warm stimulation to the part of the vulva is avoided, and the treatment results are shown in table 1.
Table 1 shows the results of the treatment of the 156 patients with leukoplakia vulvae with the Chinese herbal medicine ointment prepared in example 1 of the present invention
Table 1 shows that the cure rate is 80.1%, the effective rate is 15.4%, the ineffective rate is 4.5%, and the total effective rate: the cure rate and the effective rate are 95.5 percent.
EXAMPLE 3 treatment of leukoplakia vulvae
The histopathological changes of the leukoplakia vulvae of the patient are observed, and the results are as follows:
as shown in FIG. 1, in the pathological tissue biopsy of the patient before treatment (HE X200), it can be seen that the stratum corneum is atrophied, the continuity is interrupted, the epithelial layer is remarkably proliferated, and the dermal layer is edematous with a large amount of chronic inflammatory cell infiltration.
As shown in fig. 2, the pathological tissue biopsy of the patient (HE × 200) treated by the Chinese herbal medicine paste prepared in example 1 of the present invention shows that the stratum corneum is obviously and continuously restored, the epithelial layer hyperplasia is reduced, the inflammatory cells in the dermis are obviously reduced, and the small blood vessels are abundant.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.
Claims (4)
1. The Chinese herbal medicine paste for treating leukoplakia vulvae is characterized by comprising the following components in parts by weight:
5-20g of safflower, 5-20g of glossy privet fruit, 5-20g of Chinese angelica, 5-20g of fleece-flower root, 10-25g of malaytea scurfpea fruit, 30g of borneol, 5-25g of garden balsam stem, 5-20g of rhizoma polygonati, 10-25g of angelica dahurica, 3-5 centipedes, 3-15g of scorpion, 1200g of medical vaseline 800-;
the traditional Chinese medicine superfine powder is prepared from safflower, glossy privet fruit, Chinese angelica, tuber fleeceflower root, malaytea scurfpea fruit, borneol, garden balsam stem, rhizoma polygonati, angelica dahurica, centipede and scorpion by a superfine grinding technology.
2. The Chinese herbal medicine paste for treating leukoplakia vulvae as claimed in claim 1, wherein the pH value of the Chinese herbal medicine paste is 7-7.4.
3. The Chinese herbal medicine paste for treating leukoplakia vulvae as claimed in claim 1, which is characterized by comprising the following components in parts by weight:
10g of safflower, 10g of glossy privet fruit, 10g of Chinese angelica, 10g of tuber fleeceflower root, 15g of malaytea scurfpea fruit, 30g of borneol, 15g of garden balsam stem, 10g of rhizoma polygonati, 15g of angelica dahurica, 3 centipedes, 7g of scorpion, 1000g of medical vaseline, 250g of medical glycerin and 150g of edible white vinegar.
4. The method for preparing a Chinese herbal paste for the treatment of leukoplakia vulvae as claimed in any one of claims 1 to 3, wherein the preparation method comprises:
5-20g of safflower, 5-20g of glossy privet fruit, 5-20g of angelica, 5-20g of fleece-flower root, 10-25g of fructus psoraleae, 30g of borneol, 5-25g of garden balsam stem, 5-20g of rhizoma polygonati, 10-25g of angelica dahurica, 3-5 centipedes and 3-15g of scorpion are dried, sterilized by ultraviolet rays, coarsely crushed and processed, and then the mixture is prepared into traditional Chinese medicine superfine powder by a superfine crushing technology;
1200g of medical vaseline-.
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Cited By (1)
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CN116270836A (en) * | 2023-03-30 | 2023-06-23 | 沈阳沈大医院有限公司 | External pharmaceutical composition for treating leukoplakia vulvae |
Citations (2)
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CN1899512A (en) * | 2006-07-26 | 2007-01-24 | 肖雁冰 | Chinese herbal medicine paste for treating hard atrophic type dystrophy of vulva |
CN104398791A (en) * | 2014-09-03 | 2015-03-11 | 遵义市妇女儿童医院 | Medicine for treating vulvar lichen sclerosus and preparation method and application thereof |
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2020
- 2020-12-24 CN CN202011551515.2A patent/CN112641881A/en active Pending
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CN1899512A (en) * | 2006-07-26 | 2007-01-24 | 肖雁冰 | Chinese herbal medicine paste for treating hard atrophic type dystrophy of vulva |
CN104398791A (en) * | 2014-09-03 | 2015-03-11 | 遵义市妇女儿童医院 | Medicine for treating vulvar lichen sclerosus and preparation method and application thereof |
Non-Patent Citations (3)
Title |
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汪涛,等: "中药超微粉碎的研究进展与应用前景", 《药学实践杂志》 * |
肖雁冰,等: "两种专利中草药膏基质改变对其性质影响的实验研究", 《遵义医学院学报》 * |
肖雁冰,等: "中草药膏治疗慢性外阴营养不良76例临床研究", 《遵义医学院学报》 * |
Cited By (1)
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CN116270836A (en) * | 2023-03-30 | 2023-06-23 | 沈阳沈大医院有限公司 | External pharmaceutical composition for treating leukoplakia vulvae |
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