CN112603861A

CN112603861A - Head detergent and preparation method thereof

Info

Publication number: CN112603861A
Application number: CN202110047851.1A
Authority: CN
Inventors: 杨晶; 郭琳; 约翰·克里斯托弗·库什; 李迦勒
Original assignee: Aomei Innovation Co; Bright Future Pharmaceutical Laboratories Ltd
Current assignee: Aomei Innovation Co; Bright Future Pharmaceutical Laboratories Ltd
Priority date: 2021-01-14
Filing date: 2021-01-14
Publication date: 2021-04-06

Abstract

The application relates to the technical field of washing and caring articles, and provides a head detergent which comprises the following components in percentage by weight, based on the total weight of the head detergent being 100%: 4.0-6.5% of coal tar extract, 30.0-35.0% of surfactant and 0.05-0.3% of mint extract; 0.3-0.6% of plant essential oil; 4-8% of an auxiliary agent; the balance of water. The head washing agent adopts the coal tar extract as an active ingredient, contains the surfactant, the mint extract, the plant essential oil and the auxiliary agent, has the obvious effects of clearing heat and removing toxicity and relieving scalp itch, has good physical stability, uniform appearance character, mild smell and low irritation, has the obvious effect of inhibiting propionibacterium acnes, and has better effect on dandruff caused by seborrheic dermatitis and seborrheic scalp psoriasis.

Description

Head detergent and preparation method thereof

Technical Field

The application belongs to the technical field of washing and caring articles, and particularly relates to a head detergent and a preparation method thereof.

Background

The head is a place with more sebaceous glands, the sebaceous glands of the skin secrete sebum which is a normal physiological function, but if the sebaceous glands secrete excessive sebum, the sebum is excessively discharged and accumulated on the skin, and chronic skin inflammation can occur at the accumulated part to cause seborrhoeic dermatitis. Seborrheic dermatitis is manifested by a erythematous scalp which is covered with an off-white bran-like scale accompanied by itching. The vigorous secretion of sebaceous glands leads to the massive proliferation of propionibacterium acnes, which further stimulates the release of inflammatory factors, aggravates the inflammatory response, leads to excessive dandruff, or scalp psoriasis.

Coal Tar (Coal Tar), one of the products generated by pyrolyzing Coal, is black or brown, is viscous liquid and slightly soluble in water, and has special pungent smell. The wide clinical application shows that the coal tar can inhibit epidermal hyperplasia in some proliferative diseases and has quick and obvious antiparasitic, antifungal and antibacterial effects. Due to the good effects of promoting cutin, resisting acanthosis and vasoconstriction, the effects of cooling blood, removing fat, relieving itching and astringing are achieved. The coal tar has low cost and low systemic toxicity, and is a better component for resisting bacteria and relieving inflammation. The head washing liquid containing coal tar as main component has effects of slowing down reproduction of fungus cells, inhibiting dandruff and pruritus caused by seborrheic dermatitis, reducing mitosis activity of hyperplastic epidermis by inhibiting metabolism of enzyme, recovering proliferation of epidermal cells, improving scalp environment, and inhibiting dandruff recurrence.

In the prior art, a head detergent partially containing coal tar is disclosed, but the use experience of the head detergent is poor and the head detergent is difficult to accept by consumers because the obtained product mostly has intolerable taste and strong irritation to the scalp; meanwhile, the preparation process is complex due to complex component content, so that the wide production is difficult, and the application of the preparation process is limited.

Disclosure of Invention

The application aims to provide a head detergent and a preparation method thereof, and aims to solve the problems that the head detergent containing coal tar in the prior art is high in irritation to scalp and unpleasant in smell.

In order to achieve the purpose of the application, the technical scheme adopted by the application is as follows:

in a first aspect, the present application provides a head detergent, comprising the following components in percentage by weight, based on the total weight of the head detergent being 100%:

in a second aspect, the present application provides a method for preparing a head detergent, comprising the steps of:

providing components according to said head wash;

mixing a surfactant, a mint extract, plant essential oil, an auxiliary agent and water to obtain a first mixed solution;

and mixing the coal tar extract and the first mixed solution to obtain the head detergent.

According to the head washing agent provided by the first aspect of the application, 4.0-6.5 wt% of coal tar extract is used as an effective component of the washing agent, wherein the mint extract component is added in a synergistic manner, and the addition of the coal tar extract is reduced, so that the mint extract and the mint extract act in a synergistic manner to improve seborrheic dermatitis, and the mint extract has a good inhibition effect on scalp itching caused by seborrheic dermatitis, has a penetration promoting effect, can help the coal tar extract to go deep into the skin, especially the core of an inflammation area, and achieves good sterilization and inflammation diminishing effects; meanwhile, the plant essential oil is added to have a synergistic effect with the plant essential oil, so that the head detergent is ensured not to have strong characteristic smell of coal tar, and the obtained detergent is easy to be accepted by consumers; the detergent further comprises a surfactant and an auxiliary agent, and the surfactant and the auxiliary agent are added to further improve the performance of the head detergent; the obtained head detergent has the effect of obviously inhibiting propionibacterium acnes, has better effect on seborrheic dermatitis, dandruff excess caused by the seborrheic dermatitis and seborrheic scalp psoriasis, simultaneously reduces irritation to skin and pungent smell of coal tar, has stable property, itching relieving, cooling and good physical stability, and is beneficial to wide application.

According to the preparation method of the head detergent provided by the second aspect of the application, the surfactant, the mint extract, the plant essential oil, the auxiliary agent and the water are mixed firstly and then are mixed with the coal tar extract, the preparation method is simple and convenient to operate, the flow is simple, large-scale instruments and equipment are not needed, a heating or cooling device is not needed, and the head detergent obtained by the preparation method has good physical stability, uniform appearance and properties, mild smell and low irritation, and has a remarkable inhibition effect on propionibacterium acnes.

Detailed Description

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present application more clearly apparent, the present application is further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.

In this application, the term "and/or" describes an association relationship of associated objects, meaning that there may be three relationships, e.g., a and/or B, which may mean: a is present alone, A and B are present simultaneously, and B is present alone. Wherein A and B can be singular or plural. The character "/" generally indicates that the former and latter associated objects are in an "or" relationship.

In the present application, "at least one" means one or more, "a plurality" means two or more. "at least one of the following" or similar expressions refer to any combination of these items, including any combination of the singular or plural items. For example, "at least one (a), b, or c", or "at least one (a), b, and c", may each represent: a, b, c, a-b (i.e., a and b), a-c, b-c, or a-b-c, wherein a, b, and c may be single or plural, respectively.

It should be understood that, in various embodiments of the present application, the sequence numbers of the above-mentioned processes do not mean the execution sequence, some or all of the steps may be executed in parallel or executed sequentially, and the execution sequence of each process should be determined by its function and inherent logic, and should not constitute any limitation to the implementation process of the embodiments of the present application.

The terminology used in the embodiments of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in the examples of this application and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

The weight of the related components mentioned in the description of the embodiments of the present application may not only refer to the specific content of each component, but also represent the proportional relationship of the weight among the components, and therefore, the content of the related components is scaled up or down within the scope disclosed in the description of the embodiments of the present application as long as it is scaled up or down according to the description of the embodiments of the present application. Specifically, the mass described in the specification of the embodiments of the present application may be a mass unit known in the chemical industry field such as μ g, mg, g, kg, etc.

The terms "first" and "second" are used for descriptive purposes only and are used for distinguishing purposes such as substances from one another, and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. For example, a first XX may also be referred to as a second XX, and similarly, a second XX may also be referred to as a first XX, without departing from the scope of embodiments of the present application. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.

According to a first aspect of the embodiments of the present application, there is provided a head detergent, including the following components in percentage by weight, based on the total weight of the head detergent as 100%:

according to the head washing agent provided by the first aspect of the application, the coal tar extract with the weight percentage content of 4.0-6.5% is used as an effective component of the washing agent, wherein the mint extract component is added in a synergistic manner, so that the mint extract component and the mint extract act in a synergistic manner to improve seborrheic dermatitis due to the fact that the addition amount of the coal tar extract is reduced, and the head washing agent has a good inhibiting effect on scalp pruritus caused by seborrheic dermatitis; meanwhile, the plant essential oil is added to have a synergistic effect with the plant essential oil, so that the head detergent is ensured not to have strong characteristic smell of coal tar, and the obtained detergent is easy to be accepted by consumers; the detergent further comprises a surfactant and an auxiliary agent, and the surfactant and the auxiliary agent are added to further improve the performance of the head detergent; the obtained head detergent has the effect of obviously inhibiting propionibacterium acnes, has better effect on seborrheic dermatitis, dandruff excess caused by the seborrheic dermatitis and seborrheic scalp psoriasis, simultaneously reduces irritation to skin and pungent smell of coal tar, has itching relieving, cooling and good physical stability, and is beneficial to wide application.

Specifically, the head washing agent comprises 4.0-6.5 wt% of coal tar extract, wherein the total weight of the head washing agent is 100%. The addition amount of the coal tar extract is controlled, so that the addition amount of the coal tar extract is small, on one hand, the obtained head detergent is ensured to have small irritation to skin, the skin is ensured not to be damaged, and meanwhile, the obtained head detergent is ensured to have mild smell and is easier to be accepted by consumers; on the other hand, the weight percentage content of the coal tar extract is controlled to be moderate, so that the obtained head detergent can soften cutin, prevent formed plaques from continuously growing, and reduce the formation of large-area red plaques; meanwhile, the Chinese medicinal preparation has an inhibiting effect on the growth of fungi and relieves inflammatory reaction, thereby achieving the effect of relieving itching. If the addition amount of the coal tar extract is too small, the obtained head detergent has poor treatment effect on the skin and cannot improve the microenvironment of the scalp; if the addition amount of the coal tar extract is too large, the irritation of the head detergent is too large, the pungent smell is too strong, and the wide application of the product is not facilitated.

In a specific embodiment of the invention, the weight percentage of the coal tar extract in the head wash is 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%.

Because the coal tar is one of the products generated by pyrolyzing coal, the coal tar contains aromatic hydrocarbon, polycyclic aromatic hydrocarbon and heterocyclic aromatic hydrocarbon mixture containing nitrogen, oxygen and sulfur; due to the complex components, most of the prior art uses coal tar stock solution as raw material, and the direct use of the coal tar stock solution can cause the concentration of coal tar in the product to be too high, thereby causing damage to skin. In the application, the coal tar extract is added as a main component, so that the effective components are enough and cannot damage the skin in the using process.

In some embodiments, the coal tar extract is selected from an ethanol solution extract of coal tar. The coal tar ethanol solution is brown or light brown liquid, has similar viscosity to water, is easy to pour and is easy to be uniformly mixed with the aqueous matrix. The smell of the coal tar ethanol solution is obviously reduced compared with that of the coal tar stock solution, the smell stimulation to production operators and the smell pollution to production environment are greatly avoided by using the coal tar ethanol solution as the raw material for producing the coal tar products, and the defects of difficult storage, difficult operation and the like by directly using the coal tar stock solution as the raw material are also avoided. In a specific implementation of the present application, an ethanol solution extract of coal tar is provided that meets the requirements of the United States Pharmacopeia (USP).

Wherein the preparation method of the ethanol solution extract of the coal tar comprises the following steps: mixing coal tar stock solution with sandstone, adding polysorbate and ethanol, and soaking for 7 days to obtain ethanol solution extract of coal tar.

Furthermore, the mass percentage concentration of the coal tar extract is 15-25%. The mass percentage concentration of the coal tar extract is controlled, so that the high solubility of the coal tar can be ensured, and the effective components are dissolved in the ethanol solution. If the mass percentage concentration of the coal tar extract is too low, the requirement of inhibiting the seborrheic dermatitis cannot be met; if the mass percentage concentration of the coal tar extract is too high, the raw material is crystallized, and the physicochemical uniformity of the extract is further influenced. In the specific embodiment of the invention, the mass percentage concentration of the coal tar extract is 20%.

In some embodiments, the head washing agent is selected from a coal tar extract, wherein the density of the ethanol solution of the coal tar is 0.84g/mL, and the head washing agent contains 1.0-1.5 wt% of coal tar stock solution due to the fact that the coal tar extract accounts for 4.0-6.5 wt% of the total weight of the head washing agent as 100%.

Specifically, the head washing agent comprises 30.0-35.0 wt% of surfactant based on 100 wt% of the total weight of the head washing agent, and the surfactant is added, so that the obtained head washing agent is good in stability and can be stably stored, meanwhile, the flexibility of the head washing agent can be remarkably improved, hairs and skins are strengthened and protected, and the head washing agent is more beneficial to use. If the addition amount of the surfactant is too much, the condition requirement in the preparation process can be improved, higher temperature and more complex preparation flow need to be provided for treatment, and the product is not favorable for production; if the amount of the surfactant added is too small, the stability of the product is impaired, and the improvement of the overall performance of the head detergent is not facilitated.

In particular embodiments of the invention, the surfactant is present in an amount of 30.0%, 30.5%, 31.0%, 31.5%, 32.0%, 32.5%, 33.0%, 33.5%, 34.0%, 34.5%, 35.0% by weight.

Further, the surfactant is selected from at least one of sodium lauryl ether sulfate, cocobetaine and laureth.

In some embodiments, the surfactant is selected from sodium lauryl ether sulfate, which is a hydrophilic surfactant, is miscible with coal tar extract, has detergency, emulsification and excellent foaming power, and can improve the detergency, emulsification and foaming power of the head detergent when added as a surfactant.

In some embodiments, the surfactant is selected from cocobetaine, which is a zwitterionic surfactant having excellent stability under both acidic and basic conditions, exhibiting cationic and anionic properties, respectively; the detergent is easy to mix with coal tar extract, has low irritation, is easy to dissolve in water, and can effectively improve the properties of a head detergent.

In some embodiments, the surfactant is selected from laureth, which is capable of stabilizing the head detergent components, facilitating mixing with other components.

Specifically, the head washing agent comprises 0.05-0.3 wt% of mint extract, wherein the weight percentage of the mint extract is 100% of the total weight of the head washing agent; the mint extract and the coal tar extract have a synergistic effect, so that on one hand, the composition can improve seborrheic dermatitis and has a good effect of inhibiting scalp itching caused by the seborrheic dermatitis; meanwhile, the mint extract has the function of promoting permeation, can help the coal tar extract to deeply penetrate into the skin, particularly the core of an inflammation area, and achieves good sterilizing and inflammation diminishing effects; on the other hand, the mint extract has mint fragrance, and can improve the smell of the coal tar extract, so that the obtained head detergent has mild smell. If the addition amount of the mint extract is too small, the compounding effect of the mint extract and coal tar is affected, so that the obtained head detergent is poor in effect and cannot play a role in improving seborrheic dermatitis and inhibiting pruritus; if the amount of the mint extract added is too large, the use feeling is affected by the excessive addition because the mint extract has a cooling effect.

In one embodiment of the invention, the weight percentage of the mint extract is 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%.

In some embodiments, the mint extract is selected from at least one of menthol and peppermint oil. The menthol and the peppermint oil have the effects of deeply cleaning the skin, effectively removing oil and preventing the accumulation of skin pore toxins; at the same time, menthol and peppermint oil have a penetration-promoting effect, which helps the active principle penetrate deep into the skin, especially in the core of the inflamed area, and improves patient compliance by increasing the cooling and itching-relieving effect.

In some embodiments, the mint extract is obtained by extracting mint leaves, stems and buds through a steam distillation method, and the preparation process is simple and easy to operate.

Specifically, the head washing agent comprises 0.3-0.6 wt% of plant essential oil based on 100 wt% of the total weight of the head washing agent; the plant essential oil and the coal tar extract are added for synergistic action, so that the head detergent is ensured not to have strong characteristic smell of coal tar, and the obtained detergent is easy to be accepted by consumers. If the amount of the plant essential oil added is too small, the odor of the head detergent cannot be effectively improved.

In the specific embodiment of the invention, the plant essential oil is 0.3%, 0.35%, 0.37%, 0.40%, 0.42%, 0.45%, 0.47%, 0.50%, 0.52%, 0.55%, 0.57%, 0.6% by weight.

Further, the plant essential oil is at least one selected from lavender essential oil and pine needle essential oil.

In some embodiments, the plant essential oil is selected from lavender essential oil obtained by steam distillation of inflorescence of lavender belonging to family Labiatae. The odor of the head detergent can be improved due to its fragrant odor; and has the effects of balancing oily secretion of skin, effectively improving the oil secretion of a head detergent in a seborrheic dermatitis area and reducing the generation of oily-fungal dandruff in the using process.

In some embodiments, the plant essential oil is selected from pine needle essential oil, which is also called fir oil, and is prepared from needle leaves and twigs of fir of Pinaceae by steam distillation. The odor of the head detergent is improved, and meanwhile, the itching and irritation of sweat on an inflammation area can be reduced, so that the overall property of the head detergent is further improved.

Specifically, the head washing agent comprises 4-8 wt% of an auxiliary agent based on 100 wt% of the total weight of the head washing agent, and the performance of the head washing agent can be further improved by adding the auxiliary agent; the obtained head washing agent has good effect on seborrheic dermatitis, excessive dandruff caused by seborrheic dermatitis and seborrheic scalp psoriasis, simultaneously reduces irritation to skin, has no unpleasant odor, and is beneficial to wide application.

Further, the auxiliary agent comprises the following components in percentage by weight:

0.04 to 1.5 percent of preservative

0.1 to 0.2 percent of chelating agent

1.5 to 5 percent of thickening agent

In some embodiments, the auxiliary agent comprises 0.04-1.5 wt% of preservative, and the preservative is added to inhibit microbial activity and prevent the head detergent from deteriorating and further affecting use. If the amount of the preservative added is too large, the overall properties of the product are affected, and if the amount is too small, the effect of inhibiting microbial infection and growth is not obtained.

In particular embodiments of the invention, the preservative is present in an amount of 0.04%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.55%, 0.6%, 0.65%, 0.7%, 0.75%, 0.8%, 0.85%, 0.9%, 0.95%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5% by weight.

In some embodiments, the preservative is selected from at least one of benzyl alcohol, methylisothiazolinone/methylchloroisothiazolinone, and p-chloroxylenol. The selected preservative is a broad-spectrum type mildew-proof antibacterial agent, can act on most conventional bacteria, and has the advantages of heat resistance and acid and alkali resistance, so that the preservative can achieve effective action in a head detergent product.

Furthermore, methylisothiazolinone/methylchloroisothiazolinone is added and used in a mixture form, wherein the mass ratio of the methylisothiazolinone to the methylchloroisothiazolinone is 3:1, and the mixed preservative of the methylisothiazolinone/methylchloroisothiazolinone can effectively achieve the effects of mildew resistance and bacteria resistance.

In some embodiments, the auxiliary agent comprises 0.1-0.2 wt% of a chelating agent, the chelating agent is added to ensure that the head detergent can chelate Ca ions and Mg ions contained in hard water in the using process, and the using effect of the head detergent is poor due to the serious defoaming function of the Ca ions and the Mg ions, so that the foaming effect of the head detergent can be improved by adding a small amount of the chelating agent.

In particular embodiments of the invention, the chelating agent is present in an amount of 0.1%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.2% by weight.

In some embodiments, the chelating agent is selected from at least one of disodium ethylenediaminetetraacetate, disodium calcium ethylenediaminetetraacetate, and tetrahydroxypropylethylenediamine. The disodium ethylene diamine tetraacetate, namely the common EDTA, has six coordination atoms and can form a stable chelate, so that the disodium ethylene diamine tetraacetate is used as the chelating agent, and a better chelating effect can be ensured.

In some embodiments, the auxiliary agent comprises 1.5-5% by weight of a thickener; the thickening agent is added to improve the viscosity of the head detergent, so that the head detergent is kept in a stable suspension state or an emulsion state, and has a corresponding emulsification effect.

In particular embodiments of the invention, the weight percentage of the thickener is 1.5%, 1.8%, 2.0%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.4%, 3.6%, 3.8%, 4.0%, 4.2%, 4.4%, 4.6%, 4.8%, 5.0%.

In some embodiments, the thickener is selected from at least one of sodium chloride, polyethylene glycol methyl glucose dioleate. Further, when the thickening agent is selected from sodium chloride materials, the sodium chloride is a sodium chloride aqueous solution, and the mass percentage concentration of the sodium chloride aqueous solution is 10% -15%. The sodium chloride solution is added, so that the sodium chloride solution can be uniformly mixed with other components, and the stability of the sodium chloride solution is ensured.

In a second aspect of the embodiments of the present application, there is provided a method for preparing a head detergent, including the steps of:

s01, providing components according to a head detergent;

s02, mixing a surfactant, a mint extract, plant essential oil, an auxiliary agent and water to obtain a first mixed solution;

and S03, mixing the coal tar extract and the first mixed solution to obtain the head detergent.

In step S01, the components are provided according to the head detergent, and the types and amounts of the components are as described above, and will not be described herein for brevity.

In step S02, a surfactant, a mint extract, a plant essential oil, an auxiliary agent, and water are mixed to obtain a first mixed solution.

Furthermore, the temperature of mixing treatment is 20-25 ℃, and because the stability of each component substance provided by the application is strong, the components can be uniformly mixed at the room temperature of 20-25 ℃, heating or cooling treatment is not needed, and the operation is simple and convenient.

In some embodiments, when the adjuvant is selected from a mixture of a preservative, a chelating agent, and a thickener, the step of performing the mixing process to obtain the first mixed solution includes the following:

s021, carrying out first mixing treatment on a surfactant, a chelating agent, a preservative and water to obtain a first solution;

s022, performing second mixing treatment on the mint extract, the plant essential oil and the first solution to obtain a second solution;

s023, carrying out third mixing treatment on the thickening agent and the second solution to obtain a first mixed solution.

In S021, in the step of performing first mixing treatment on the surfactant, the chelating agent, the preservative and water, the rotation speed of the first mixing treatment is 60-100 revolutions per minute, and the mixing treatment time is 30-35 minutes.

In S022, in the step of performing the second mixing treatment on the mint extract, the plant essential oil and the first solution, the rotation speed of the second mixing treatment is 60 to 100 revolutions per minute, and the time of the mixing treatment is 30 to 35 minutes.

In S023, in the step of performing the third mixing treatment on the thickener and the second solution, the rotation speed of the second mixing treatment is 150-200 rpm, and the time of the mixing treatment is 30-35 minutes.

In step S03, the coal tar extract and the first mixed solution are subjected to mixing treatment to obtain a head detergent. In some embodiments, the coal tar extract and the first mixed solution are stirred for 45-50 minutes at 150-200 rpm, so as to obtain the head detergent.

The following description will be given with reference to specific examples.

Example 1

Head detergent and preparation method thereof

Head detergent

The total weight of the head detergent is 100%, and the components and the addition amount are shown in table 1:

TABLE 1

Preparation method of head detergent

The preparation method comprises the following steps:

the head detergent according to example 1 provided the components;

adding surfactant sodium lauryl ether sulfate, cocobetaine, laureth alcohol, preservative benzyl alcohol, parachlorometaxylenol, methylisothiazolinone/methylchloroisothiazolinone mixture and chelating agent disodium ethylene diamine tetraacetate into pure water at room temperature, and stirring for 30 minutes at the rotating speed of 60/minute to obtain a first solution;

mixing the plant essential oil pine needle essential oil, the lavender essential oil, the mint essential oil, the menthol and the first solution at room temperature, and stirring for 30 minutes at the rotating speed of 80 rpm to obtain a second solution;

stirring the second solution, thickening agent polyethylene glycol methyl glucose dioleate and sodium chloride solution for 30 minutes at the rotation speed of 150 rpm to form a first mixed solution;

and mixing the coal tar ethanol solution and the first mixed solution at room temperature, and stirring for 45 minutes at the rotation speed of 150 rpm to obtain the head detergent.

Example 2

Head detergent and preparation method thereof

Head detergent

The total weight of the head detergent is 100%, and the components and the addition amount are shown in table 2:

TABLE 2

Preparation method of head detergent

The preparation method comprises the following steps:

the head detergent according to example 2 provides the components;

adding surfactant sodium lauryl ether sulfate, cocobetaine, laureth alcohol, preservative benzyl alcohol, parachlorometaxylenol, methylisothiazolinone/methylchloroisothiazolinone mixture and chelating agent disodium ethylene diamine tetraacetate into pure water at room temperature, and stirring for 30 minutes at the rotating speed of 80 rpm to obtain a first solution;

mixing the plant essential oil pine needle essential oil, the mint essential oil, the menthol and the first solution at room temperature, and stirring for 30 minutes at the rotating speed of 100 rpm to obtain a second solution;

stirring the second solution, thickening agent polyethylene glycol methyl glucose dioleate and sodium chloride solution for 30 minutes at the rotating speed of 180 rpm to form a first mixed solution;

and mixing the coal tar ethanol solution and the first mixed solution at room temperature, and stirring for 45 minutes at the rotation speed of 200/minute to obtain the head detergent.

And (3) performance testing:

performance test (one): physical stability test

The physical stability is the key for ensuring whether the cosmetics are safe and effective. The stability test is to keep the tested product in different environmental conditions for a certain time, and to follow up to investigate whether the uniformity of the product has significant changes.

Analyzing the appearance, odor type, viscosity and pH of the finished product of the head washing agent obtained in the embodiment 1-2 under the conditions of room temperature, cold resistance test, heat resistance test and centrifugation test respectively;

wherein the cold resistance test condition is that the temperature is kept at minus 8 plus or minus 2 ℃ for 24 hours and then the temperature is returned to the room temperature;

the heat resistance test condition is that the temperature is maintained at 40 plus or minus 2 ℃ for 24 hours and then the temperature is returned to the room temperature;

the centrifugal test condition is that the centrifugal treatment is carried out for 20 minutes under the condition of 3000 revolutions per minute;

the viscosity test is carried out by using a Brookfield DV3T viscometer of a test instrument;

the pH test was carried out using a Metrohm 914pH meter.

Performance test (ii): anti-Propionibacterium acnes test

Propionibacterium acnes is a normal flora on the surface of human skin, mainly inhabits in skin hair follicle sebaceous glands, provides a proper environment for the Propionibacterium acnes if the sebaceous glands are hypersecretion to form an oily skin environment, and the massive proliferation of the Propionibacterium acnes causes the imbalance of the skin flora, thereby stimulating the release of inflammatory factors, damaging the sebaceous glands and initiating inflammatory reaction.

The procedure for the anti-propionibacterium acnes test method is as follows: the head detergents prepared in examples 1 and 2 were diluted once with distilled water, and an appropriate amount of the diluted solution was taken. Blood agar plates, which had been anaerobically cultured for 24 hours and on which colonies of acnes were evenly distributed, were soaked in the diluent. The control group used the same volume of distilled water. In order to simulate daily use conditions, the soaking treatment time was 5 minutes. Thereafter, the sample solution was washed with a sufficient amount of distilled water. And (4) performing anaerobic culture on the treated bacterial plate for 72 hours, and counting by using a viable count method.

And (4) analyzing results:

performance test (one): physical stability test

Analyzing the appearance, odor type, viscosity and pH of the finished product of the head washing agent obtained in the embodiment 1-2 under the conditions of room temperature, cold resistance test, heat resistance test and centrifugation test respectively; the results are shown in table 3 below, and the analysis of the appearance, odor type, viscosity and pH of the finished product of the head washing agent obtained in examples 1-2 under the room temperature condition, the cold resistance test condition, the heat resistance test condition and the centrifugation test condition respectively meets the detection standards, and the appearance is brown homogeneous viscous liquid without layering and precipitation; the odor type is mint odor; viscosity of 80-120cps, and pH of 5.0-7.0; therefore, the head washing agents obtained in examples 1 to 2 were physically stable.

TABLE 3

Performance test (ii): anti-Propionibacterium acnes test

The head washing agents obtained in examples 1 to 2 were subjected to the Propionibacterium acnes resistance test, and it was found from the results in Table 4 that the average viable cell of Propionibacterium acnes in the control group was 2.2X10 when the test was performed at the same action concentration and time⁴cfu/mL; the average viable bacteria of the propionibacterium acnes treated in example 1 is less than 10 cfu/mL; example 2 the average viable bacteria of Propionibacterium acnes after treatment was < 10 cfu/mL.

According to the evaluation criteria of the effect of the test against propionibacterium acnes, it can be seen that: when the bacteriostatic rate is more than 90%, the product has a strong bacteriostatic action, and when the bacteriostatic rate is 50-90%, the product has the bacteriostatic action; as can be seen from table 4, the results for the average inhibition rate of example 1 were calculated to be > 99.95%, and the results for the average inhibition rate of example 1 were reported to be > 99%; the results for the average inhibition rate of example 2 were calculated to be > 99.95%, and the results for the average inhibition rate of example 2 were reported to be > 99%; therefore, the head washing agent products obtained in the examples 1 and 2 have the bacteriostasis rate of more than 99 percent on the propionibacterium acnes and have stronger bacteriostasis

TABLE 4

In conclusion, the head washing agent provided by the application adopts the coal tar extract with the weight percentage of 4.0-6.5% as the effective component of the washing agent, wherein the mint extract component is added in a synergistic manner, and the addition of the coal tar extract is reduced, so that the head washing agent has a synergistic effect with the mint extract, improves seborrheic dermatitis, has a good inhibition effect on scalp itching caused by seborrheic dermatitis, has a penetration promoting effect on the mint extract, can help the coal tar extract to go deep into the skin, particularly the core of an inflammation area, and achieves good sterilization and inflammation diminishing effects; meanwhile, the plant essential oil is added to have a synergistic effect with the plant essential oil, so that the head detergent is ensured not to have strong characteristic smell of coal tar, and the obtained detergent is easy to be accepted by consumers; the detergent further comprises a surfactant and an auxiliary agent, and the surfactant and the auxiliary agent are added to further improve the performance of the head detergent; the obtained head detergent has the effect of obviously inhibiting propionibacterium acnes, has better effect on seborrheic dermatitis, dandruff excess caused by the seborrheic dermatitis and seborrheic scalp psoriasis, simultaneously reduces irritation to skin and pungent smell of coal tar, has stable property, itching relieving, cooling and good physical stability, and is beneficial to wide application.

The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. The head detergent is characterized by comprising the following components in percentage by weight based on the total weight of the head detergent as 100 percent:

2. the head detergent according to claim 1, wherein the coal tar extract is selected from an ethanol solution extract of coal tar.

3. The head washing agent according to claim 2, wherein the coal tar extract is present in a concentration of 15 to 25% by mass.

4. The head washing agent according to any one of claims 1 to 3, wherein the surfactant is at least one selected from the group consisting of sodium lauryl ether sulfate, cocobetaine, and laureth.

5. The head washing agent according to any one of claims 1 to 3, wherein the mint extract is at least one selected from the group consisting of menthol and peppermint oil.

6. The head washing agent according to any one of claims 1 to 3, wherein the plant essential oil is at least one selected from lavender essential oil and pine needle essential oil.

7. The head washing agent according to any one of claims 1 to 3, wherein the auxiliary comprises the following components in percentage by weight:

0.04-1.5% of preservative;

0.1-0.2% of a chelating agent;

1.5-5% of a thickening agent.

8. The head detergent according to claim 6, wherein the preservative is selected from at least one of benzyl alcohol, methylisothiazolinone/methylchloroisothiazolinone, and p-chloroxylenol; and/or the presence of a gas in the gas,

the chelating agent is at least one of disodium ethylene diamine tetraacetate, disodium calcium ethylene diamine tetraacetate and tetrahydroxypropyl ethylenediamine; and/or the presence of a gas in the gas,

the thickening agent is at least one selected from sodium chloride and polyethylene glycol methyl glucose dioleate.

9. The head detergent according to claim 8, wherein the sodium chloride is an aqueous sodium chloride solution, and the concentration of the aqueous sodium chloride solution is 10 to 15% by mass.

10. The preparation method of the head detergent is characterized by comprising the following steps:

providing components of a head wash according to any of claims 1 to 9;