CN1262611A - Methods for using compositions containing dichlorophenyl imidazoldioxolan to treat sebcrrheic dermatitis, dandruff, psoriasis, and acne, and compositions thereof - Google Patents
Methods for using compositions containing dichlorophenyl imidazoldioxolan to treat sebcrrheic dermatitis, dandruff, psoriasis, and acne, and compositions thereof Download PDFInfo
- Publication number
- CN1262611A CN1262611A CN98806837A CN98806837A CN1262611A CN 1262611 A CN1262611 A CN 1262611A CN 98806837 A CN98806837 A CN 98806837A CN 98806837 A CN98806837 A CN 98806837A CN 1262611 A CN1262611 A CN 1262611A
- Authority
- CN
- China
- Prior art keywords
- mixture
- compositions
- dichlorobenzene base
- goods
- shampoo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to compositions such as body and hair cleansing products, in particular shampoos, comprising dichlorophenyl imidazoldioxolan and methods for using such compositions to alleviate the symptoms associated with dandruff, seborrheic dermatitis, acne, and psoriasis.
Description
The cross reference of related application
The application has required the U.S. Provisional Application No.60/051 of submission on July 2nd, 1997,418 priority, and it is for referencial use that this provisional application is included this paper in full in.
Background of invention
1. invention field
The present invention relates to method and compositions for use with the combination treatment seborrheic dermatitis, the dandruff, psoriasis and the acne that contain Dichlorobenzene base imidazo dioxolanes.
2. the description of background technology
The traditional method of treatment skin and scalp affections (as the dandruff, seborrheic dermatitis, psoriasis and acne) comprises that local application can 1) suppress skin surface growth of microorganism, 2) reduce that skin surface stimulates and/or 3) reduce the medicament that sebum produces on the skin surface.
Treating in the first method of these diseases by suppressing growth of microorganism (particularly malassezia furfur (malassezia furfur (pityrosporum ovale)) growth), one or more known malassezia furfur inhibitor have been added in the product, as ketoconazole, selenium sulfide, pyrithione zinc, coal tar and Octopirox cholamine.
United States Patent (USP) 4,569,935 disclose ketoconazole can be used for topical therapeutic psoriasis and seborrheic dermatitis.The known shampoo that contains 2% ketoconazole has good effect to the treatment seborrheic dermatitis after local application.Also know, made the stable shampoo that contains 2% following active component.This shampoo has better cosmetic property (as spume and nurse one's health).Referring to United States Patent (USP) 5,456,851.
The known method of another kind of one or more above-mentioned diseases of treatment comprises and alleviates the symptom relevant with these diseases, as delamination, desquamation, itch.A kind of method is the local application keratolytic, the promptly a kind of medicament that can remove the excessive cell that accumulates on the skin surface effectively.Referring to IL113057.Alleviate itch, stimulation and xerodermatic other method comprise type and the consumption of regulating used detergent.Referring to WO-96/29983 (contain in the 4-12% weight anion surfactant of having an appointment, amphoteric surfactant (amphoteric surfactant of above-mentioned anion surfactant at least 0.75 weight portion of every weight portion) and the listed 11 kinds of therapeutic agents one or more mild detergent water composition).
Though coal tar only has an effect to suppressing the malassezia furfur breeding, known it to suppress DNA effectively synthetic, thereby also suppressed the division of cell.Because as if the symptom that cell proliferation and accumulation produce delamination, desquamation and itch alleviated these symptoms so coal tar suppresses fissional ability.For example, WO-96/29045 has disclosed the compositions that contains cytotoxic agent and antifungal that is used for the treatment of the scalp seborrheic dermatitis synoptically.Yet it has disclosed particularly and has been used in combination unidentified compositions that contains 1.8% coal tar and the unidentified solution that contains 2% ketoconazole.
The third method of treatment seborrheic dermatitis, the dandruff, psoriasis and acne is to reduce the generation (common sympton of suffering from the skin of these diseases) of sebum on the skin surface.It is believed that, because the sebum that the propagation of surface skin cell is gathered on skin surface in a large number provides favourable breeding environment for microorganism.For the generation that reduces sebum had once added the reagent of alcohol, solvent and surfactant and so in various therapeutic agents, but these reagent have very strong stimulation to skin, and can not suppress the breeding of malassezia furfur effectively.
Therefore, need a kind of compositions that is used for the treatment of seborrheic dermatitis, the dandruff, psoriasis, acne etc.This compositions can not only suppress the breeding of microorganism, and removes excessive skin cell and the sebum generation that reduces on the skin surface on the skin surface effectively, and does not have above-mentioned any shortcoming.
Summary of the invention
The invention provides a kind of treatment seborrheic dermatitis, the dandruff and psoriasic method, this method comprises, is made up of following steps basically or is made up of following steps:
A) on skin or hair, use the compositions that contains following component of effective dose:
1) Dichlorobenzene base imidazo dioxolanes; With
2) treatment component, it is selected from salicylic acid, coal tar and derivant thereof, Octopirox cholamine (Octopirox), selenium sulfide, Brafen or its mixture.
The compositions that another embodiment of the invention relates to and containing, is made up of following component basically or is made up of following component;
1) Dichlorobenzene base imidazo dioxolanes; With
2) therapeutic agent, it is selected from salicylic acid, coal tar and derivant thereof, Octopirox cholamine, selenium sulfide, Brafen or its mixture.
This compositions can be mixed with health as known in the art or hair cleaning product component, forms various healths and hair cleaning product, as soap, gel and shampoo.
Another embodiment of the invention relates to the preparation method of a kind of health and hair cleaning formulation, and this method comprises, is made up of following steps basically or is made up of following steps:
(a) be enough to form mixed anion surfactant and deionized water under the condition of first mixture;
(b) mix with first mixture at the Dichlorobenzene base imidazo dioxolanes and the antioxidant that are enough to form under the condition of second mixture effective dose;
(c) before adding the treatment component, second mixture is cooled to enough temperature;
(d) will treat component under the condition of the 3rd mixture and mix being enough to form with refrigerative second mixture;
(e) buffer agent and amphoteric surfactant are mixed with the 3rd mixture being enough to form under the condition of 4 mixture.
Another embodiment relates to and suppresses vegetative method on the skin surface, and this method comprises, is made up of following steps basically or is made up of following steps:
The compositions that contains Dichlorobenzene base imidazo dioxolanes of local application effective dose on skin.
We unexpectedly find, Dichlorobenzene base imidazo dioxolanes and the compositions that contains it can suppress microorganism well (as malassezia furfur and Propionibacterium (P.acne) growth.In addition, with respect to the existing shampoo and the cleaning agent that only contain a kind of component, the compositions of Dichlorobenzene base imidazo dioxolanes and one or more treatment components usually provides significant improvement and/or potentiation.Therefore, can reduce the concentration of one or both different components, thereby increase the allowance of user.
The description of preferred embodiment
In the following description, the present invention will be described as an example with shampoo, but the clear compositions of the present invention of those skilled in the art can be used for comprising bath foam, soap bar, gel etc. in other health or the hair cleaning product.
Term " MEA " comprises that general formula is RCO-NH-CH
2CH
2The single ethanol amide of-OH, " DEA " comprise that general formula is RCO-N (CH
2CH
2-OH)
2Diglycollic amide, " MIPA " comprises that general formula is RCO-NH-CH
2-CHOH-CH
3Single isopropanol amide, each RCO group is a fatty acid residue in the formula, as C
13-19Alkyl-carbonyl or C
13-19Alkenyl carbonyl; " TEA " is meant triethanol ammonium.Term " both sexes " used among the application is meant 1) both contained acid two molecule that contains alkaline position, as contain the aminoacid of amino (alkalescence) and acid (as carboxylic acid, acidity) functional group; Or 2) existing positive charge has the amphiphatic molecule of negative charge again in a part.The electric charge of a kind of molecule in back can be relevant with the pH value of compositions or irrelevant.
Dichlorobenzene base imidazo dioxolanes is available from Janssen Pharmaceutica, N.V., and trade name is " Elubiol ".Though the consumption of Dichlorobenzene base imidazo dioxolanes for example depends on the type of symptom and the consumption of other blending ingredients in the present composition, but those skilled in the art need not the consumption that too many experiment just can be determined Dichlorobenzene base imidazo dioxolanes, gross weight by compositions, be about 0.1-2%, better be about 0.25-1%, more preferably 0.25-1%.As described below, the lower limit place in this scope must take special measure, can be owing to the degraded of antifungal compound when storing loses effect to guarantee shampoo.The concentration that surpasses above-mentioned scope can further not improved therapeutic effect, and more harm than good generally.
Compositions of the present invention also contains the treatment component that can obtain therapeutic effect when the treatment dandruff, seborrheic dermatitis and psoriasis effectively, and this treatment component is selected from salicylic acid, coal tar and derivant thereof (as dithranol), Octopirox cholamine (Octopirox), selenium sulfide, Brafen, other known anti-dandruff medicament or their mixture.Salicylic acid is preferably to treat component.Though the consumption of treatment component can change according to above-mentioned similar reason, those of ordinary skill in the art need not too many experiment just can determine that the consumption for the treatment of component by the gross weight of compositions is about 0.5-3%, is preferably 1-2%.
In a preferred embodiment, the consumption of Dichlorobenzene base imidazo dioxolanes and treatment component is not only to suppressing the dermophyte (growth of particularly relevant with the dandruff and seborrheic dermatitis fungus (being malassezia furfur (pityrosporum ovale)), and the growth that suppresses for example relevant with tinea capitis, tinea corporis etc. fungus (as epidermophyton, sporidiole bacteria and tinea bacterium) produced significant the improvement and/or potentiation mutually.The ratio of the consumption of Dichlorobenzene base imidazo dioxolanes and treatment component depends on the character and the control strain for the treatment of component.Specifically, the weight of Dichlorobenzene base imidazo dioxolanes and treatment component: weight ratio is expected to be 0.1: 3-2: 0.5, be preferably 0.25: 2-0.5: 1.0.Especially effectively weight ratio is about 0.5 when suppressing dermophyte (particularly malassezia furfur) propagation: 2.0-1: 1 Dichlorobenzene base imidazo dioxolanes and salicylic compositions.Beyond thought is that this compositions also produces mutual potentiation to inhibition pathogenic yeast, Candida albicans.
In another preferred embodiment, compositions of the present invention can contain Dichlorobenzene base imidazo dioxolanes, salicylic acid and be about 0-1% (better be about 0.25-1%, better be about 0.50-0.75%) Octopirox cholamine (Octopirox) by the gross weight of compositions.
The available usually shampoo base material preparation as known in the art of shampoo of the present invention; Shampoo component as known in the art comprises that the viscosity that is enough to make final preparation under one or more surfactants, foaming agent, the room temperature is thickening agent, antiseptic, the antioxidant series of 4000-9000mPa.s and to be enough to make the pH scope of shampoo be acid or alkali or the buffer agent of 3-8.A kind of component can have two or more effects, as surfactant and foaming agent.
The surfactant that is applicable to shampoo of the present invention comprises commercially available any non-ionic surface active agent, amphoteric surfactant, anion surfactant or their mixture.
One class is applicable to that ionic surfactant pack of the present invention draws together the polyoxyethylene deriv of polyol ester.The polyoxyethylene deriv of this polyol ester (1) is contained the fatty acid of about 8-22 (being preferably 10-14) carbon atom and (b) is selected from sorbitol, anhydro sorbitol, glucose, α-Jia Jiputanggan, each molecule by (a) on average has the polyhydric alcohol of polydextrose, glycerol, tetramethylolmethane and their mixture of 1-3 glucose residue to make, (2) on average contain the 10-120 that has an appointment, better about 20-80 oxygen ethylene unit; (3) polyoxyethylene deriv of per molecule (mole) polyol ester on average has 1-3 fatty acid residue.
Another kind of suitable ionic surfactant pack is drawn together chain alkyl glucoside or polyglucoside, and they are that (a) contains the long-chain alcohol of 6-22 (being preferably 8-14) carbon atom and (b) glucose approximately or contain the condensation product of the polymer of glucose.The per molecule alkyl androstanediol contains 1-6 glucose residue approximately.
Be applicable to that amphoteric surfactant of the present invention includes, but are not limited to both sexes carboxylate, alkyl betaine, amidoalkyl betanin, amidoalkyl sulfobetaines (sultaines), two acid phosphates, phosphoric acid betaine, pyrophosphoric acid betanin, carboxyalkyl alkyl polyamine and their mixture.
Suitable anion surfactant can be selected from alkyl sulfate; alkyl ether sulfate; alkyl one glyceryl ether sulfate; alkyl monoglyceryl ester sulfate; alkyl monoglyceryl ester sulfonate; alkylsulfonate; alkylaryl sulfonates; the succinic acid alkyl ester sulfonate; the alkyl ether sulfosuccinate; sulfo group succinamic acid Arrcostab; amino sulfo-succinic acid Arrcostab; the alkyl carboxylate; the alkyl amido ether carboxylate; dialkyl succinylsuccinate salt; the aliphatic acyl sarcosinate; aliphatic acyl aminoacid; the aliphatic acyl taurate; the aliphatic alkyl sulfosalicylic acetate; alkylphosphonic; and their mixture.
Preferred surfactants comprises that alkene contains the ethylenic sodium sulfonate of 14-16 carbon atom, sodium lauryl sulphate, dodecyltriethanolamine sulfate, lauryl (polyoxyethylene) ether sodium sulfate (sodium laurethsulfate), cocos nucifera oil acylamino-propyl group amine oxide (cocamidopropylamine oxide), the oxidation lauryl amine, lauroyl diethanolamine, cocoamidopropyl (cocamidopropyl betaine), the lauryl dimethyl betanin, Cortex cocois radicis oil base dimethyl methyl CAB, Cortex cocois radicis oil base sodium sarcosinate, the amino MIPA sulfo-succinic acid of oleoyl disodium, cocos nucifera oil acylamino-MIPA sulfo-succinic acid disodium, lauryl (polyoxyethylene) ether sulfo-succinic acid disodium, cocoyl both sexes carboxyl glycinate, the amino monoethanolamine sulfo-succinic acid of oleoyl disodium, glycine amine, propanoic acid amine and amine sulfobetaines (amine sultaines), and their mixture.Ethylenic sodium sulfonate wherein is most preferred.
In a preferred embodiment of shampoo of the present invention, can use two or more mean mixtures of individual surfactants, better anion surfactant and mixture, particularly lauryl (polyoxyethylene) the ether sulfonic acid sodium of amphoteric surfactant and the mixture of cocoyl sarcosine or dodecyl sodium sulfate, lauryl (polyoxyethylene) ether sulfonic acid sodium, dodecyl sodium sulfonate triethanolamine, cocos nucifera oil acylamino-propyl group amine oxide and cocoamidopropyl of using.
In compositions of the present invention, by the gross weight of compositions, the total amount of surfactant can be about 30-60%, better is about 40-50%.By the gross weight of shampoo, shampoo better contains 15-30% (better being about 20-25%) anion surfactant, about 5-20% (better about 10-15%) non-ionic surface active agent and about 10-30% (better about 20-25%) amphoteric surfactant.The weight of amphoteric surfactant better is less than 15% weight of surfactant gross weight.By the gross weight of compositions, shampoo preferably contains have an appointment 20-25% anion surfactant (as ethylenic sodium sulfonate) and about 20-25% amphoteric surfactant.By the gross weight of amphoteric surfactant, it contains 1.0-5.0% cocos nucifera oil acylamino-propyl group amine oxide and about 20-25% cocoamidopropyl.
Be applicable to that the foaming agent (suds booster and stabilizing agent) in the present composition includes, but are not limited to fatty acid list and two alkanolamides and composition thereof.The example of these amide is cocos nucifera oil acyl monoethanolamine, cocos nucifera oil acyl diethanolamine, oleoyl monoethanolamine, oleoyl diethanolamine and their mixture.The consumption of foaming agent is about 0-10% (weight) and (w/w), better is about 2-6% (weight), is preferably 4-5% (weight).These components generally also have thickening power to preparation.
The antiseptic that is applicable to shampoo of the present invention is an acceptable antiseptic on the dermatological, as sodium ethylene diamine tetracetate, methyl butex, propylparaben, oxybenzene butyl formate, oxybenzene Ethyl formate, imidazolidinyl urea, diazolidinyl urea (diazolidinyl urea), phenyl phenol, quaternium 15, citric acid, better be their mixture.Sodium ethylene diamine tetracetate and citric acid are also as chelating agen.In order to obtain the sufficiently long storage life, use antiseptic by the consumption that can suppress the final composition degraded effectively.
When the concentration of Dichlorobenzene base imidazo dioxolanes lower limit place in above-mentioned scope; the antioxidant (being selected from Yoshinox BHT (" BHT "), butylatedhydroxyanisole (" BHA "), ascorbic acid, N-acetylcysteine and sodium metabisulfite) that adds careful controlled quentity controlled variable can be stablized the Dichlorobenzene base imidazo dioxolanes in the shampoo effectively, prevents its degraded in 50 ℃ of accelerated ageing 13 time-of-weeks.It is believed that the performance that stored for 2 years under the measurable room temperature of this accelerated aging test result.Referring to United States Patent (USP) 5,456,851.Effectively stability thinks that the loss of active component is no more than 10% between the storage life.Have now found that the most effective BHT or BHA ratio are about 0.01-1% (weight).Ratio greater than this amount can not be stablized Dichlorobenzene base imidazo dioxolanes effectively during 13 all accelerated ageings.Yet, consistently on government administration section and medicine and the cosmetics industry think that the 13 peripheral stabilities test in the time of 50 ℃ is enough to predict the product stability of normal storage during 2 years under the room temperature.(promptly farthest reduce the probability of skin allergy) for reasons of safety, it is also important that needs the least possible BHT or BHA.
Because the shampoo user is wished the shampoo slightly viscous, so add one or more thickening agents usually in preparation, this thickening agent at room temperature can produce the viscosity of 4000-9000mPa.s.Suitable thickening is carbomer (carbomer) or polycarboxylic acids, as Carbopol
TM1342.This thickening agent carries out thickening by adding sodium hydroxide or sodium chloride when preparation finishes.Other thickening agent that is suitable for is xanthan gum, aluminium-magnesium silicate (veegum) and above-mentioned foaming agent (better being cocos nucifera oil acyl monoethanolamine).Though the consumption of thickening agent depends on required viscosity, by the gross weight of shampoo, the consumption of thickening agent is generally 0-2%, is preferably 0.2-1.3%.
Be applicable to that pH regulator agent of the present invention or buffer agent include, but are not limited to sodium citrate, citric acid and their mixture.The pH of shampoo of the present invention regulates with acceptable acid, alkali and buffer agent on the dermatological usually.The pH scope can be 3.0-8.0, but is preferably 3.5-5.0, and good especially is 3.7-4.2.
Randomly be used for solubilizing agent of the present invention and include, but are not limited to hexanediol, propylene glycol, butanediol and their mixture.These solubilizing agents should be by dissolving the amount of all solids use basically in the given solution effectively.
Shampoo can randomly contain conditioner (conditioner).By the gross weight of shampoo, its consumption is about 0-5%, better is about 1-3%.The example of suitable conditioner includes, but are not limited to cationic cellulose derivative; The cationic guar gum derivant; Silicone material (as ring dimethyl siloxane (cyclomethicone), polydimethylsiloxane (dimethicone)) and glyceryl derivant (as protochloride oleoyl aminopropyl Polyethylene Glycol dimethylammonium (linoleamidopropyl polyglycol dimonium chloride)) and their mixture); Be selected from the homopolymer or the copolymer of following one group of cationic monomer:
A. the monomer that has general formula I
R is H or CH in the formula
3,
Y is O or NH,
R
1Be the alkylidene that contains 2-6 (better containing 2-3 approximately) carbon atom approximately,
R
2, R
3And R
4Be respectively contain approximately 1-22 (better containing 1-4 approximately) carbon atom alkyl and
X is the monovalent anion that is selected from halogen or alkyl sulfate, or
B. chlorination diallyl dimethyl ammonium; Or their mixture.
By the gross weight of compositions, the consumption of every kind of conditioner component is about 0.01-1.0%, is preferably 0.01-0.5%, more preferably 0.01-0.2%.
Cationic cellulose derivative better comprises high molecular quaternary, as polyquaternium-7, polyquaternium-22, polyquaternium-10 or their mixture.Polyquaternium-22 preferably wherein.
The cationic guar gum derivant better be with trade name " Jaguar C-17 " available from Rhone-Poulenc Inc., of Cranbury, the chlorination guar gum hydroxypropyl trimethylammonium (guar hydroxypropyl-trimonium chloride) of New Jersey.
Another kind of preferred cation polymer comprises by the propylene dichloride acylamino-propyl group trimethylammonium derived compounds with following structural formula:
And be more preferably the copolymer of this monomer and acrylamide.The latter with trade name " Salcare SC60 " available from Allied Colloids, of Suffolk, Virginia.
Other preferred cation conditioning polymer is by monomer chlorination diallyl dimethyl ammonium derived polymers.This monomeric homopolymer be with trade name " Salcare SC30 " available from Allied Colloids, ofSuffolk, the Polyquaternium-6 of Virginia.The copolymer of chlorination diallyl dimethyl ammonium and acrylamide is called polyquaternium-7, it also with trade name " Salcare SC10 " available from AlliedColloids.
Shampoo of the present invention can randomly contain pearling agent.By the gross weight of shampoo, the content of pearling agent is about 0-3%, better is about 1-1.5%.The example of suitable pearling agent includes, but are not limited to glycol distearate, ethylene glycol monostearate and their mixture.
This shampoo also can randomly contain one or more spice and/or coloring agent.
Compositions of the present invention should be used with the effective dose of the dandruff, seborrheic dermatitis, psoriasis and/or the relevant symptom of acne by improvement.Used " effective dose " of the application is meant to be enough to cover symptom place skin surface area and can to improve the required amount of relevant symptom with various diseases.
Compositions of the present invention local application regularly is preferably 1-7 time weekly on infected body part.More preferably, use compositions of the present invention more continually in the initial period of treatment, for example weekly 4-7 time, up to reaching required effect, then when needs are kept, less using, for example weekly 1-2 time.Forms such as compositions of the present invention for example can skin cream, protective skin cream or gel are applied to required zone.The compositions of these forms is stayed after using on the skin and in a short time and can not washed off.Perhaps, compositions of the present invention for example can washing liquid, the forms such as cream, gel, soap, shampoo of washing are applied to required zone.The compositions of these forms rinses in using the back certain hour.
In a preferred embodiment that said composition is added shampoo, shampoo is applied on the wet hair, then by known method washing hair.Better before rinsing, compositions of the present invention was stayed on the hair more than 0-10 minute, better was about 4-7 minute.
In the present invention, we unexpectedly find, (a kind of known sebum will reduce agent when containing Dichlorobenzene base imidazo dioxolanes, referring to WO-93/18743) compositions local application on mammalian skin or hair the time, obviously suppressed the propagation of malassezia furfur and propionibacterium acnes.Therefore, not only there is sebum to reduce character owing to contain the compositions of Dichlorobenzene base imidazo dioxolanes, and good malassezia furfur and propionibacterium acnes growth inhibited performance arranged, so they are better than other known therapeutic agent aspect the relevant symptoms such as the dandruff, acne improving.In addition, when these compositionss also contained salicylic acid (a kind of known keratolytic), the compositions of gained had the character of effectively treating dandruff etc. by all three kinds of traditional methods.
The present invention of illustrative ground announcement in this application can suitably implement under the condition that does not have the concrete in this application component that discloses, composition or step to exist.Following several embodiment are used to further specify essence of the present invention and embodiment.Yet, should not think that the present invention is subjected to the restriction of these details.
Embodiment
Embodiment 1: preparation shampoo base material
" WitconateAOS " surfactant (containing the 39%C14-C16 ethylenic sodium sulfonate approximately) that under ambient temperature and pressure 467 gram pure water and 250 is restrained available from Witco company adds in the suitable mechanical mixture container.After the propeller speed of this container reaches 50 rev/mins, the interior temperature of this mixture is heated to 70 ℃, the internal pressure of this container is increased to 1 crust.Keep constant under the condition of temperature and internal pressure with this mixture stirring after about 15 minutes, this mixture is cooled to about 45 ℃, add 5 gram sodium citrates, 5 grams then available from Mona Industries, " Phospholipid EFA " chemical compound of Incorporated (containing 30% protochloride oleoyl aminopropyl Polyethylene Glycol dimethylammonium (linoleamidopropyl PG dimonium chloride) approximately) and 3 grams hexylene glycol.
After keeping the mixture of gained being stirred about 15 minutes under the condition of temperature and internal pressure in constant, " Chembetaine " surfactant (containing 30% cocoamidopropyl approximately), 10 grams that under agitation add available from Chemron company restrain with the polyquaternium-22 of trade name " Merquate 280 " available from Calgon company available from " Standamox CAW " chemical compound (containing 30% cocos nucifera oil acylamino-propyl group amine oxide approximately) and 20 of Henkel company.Under stationary temperature and pressure with the mixture remix of gained 20 minutes.Before the water of water that adds capacity, the temperature in this mixture is reduced to about 35 then with replenish lost.
The percetage by weight of used component is illustrated in the following table 1 in the present embodiment:
Table 1: shampoo prescription
DI=Dichlorobenzene base imidazo dioxolanes
| Component | Embodiment 1: the shampoo base material | Base material during embodiment 2:pH4 and DI | Base material during embodiment 3:pH7 and DI | Embodiment 3: base material, salicylic acid and Octopirox cholamine | Embodiment 3: base material, DI, salicylic acid and Octopirox cholamine |
| Pure water | ????79.80 | ????79.30 | ????79.30 | ????77.05 | ????76.55 |
| Ethylenic sodium sulfonate | ????9.75 | ????9.75 | ????9.75 | ????9.75 | ????9.75 |
| Dichlorobenzene base imidazo dioxolanes | ????-- | ????0.50 | ????0.50 | ????-- | ????0.50 |
| Salicylic acid | ????-- | ????-- | ????-- | ????2.00 | ????2.00 |
| Sodium citrate | ????0.50 | ????0.50 | ????0.50 | ????0.50 | ????0.50 |
| Protochloride oleoyl aminopropyl Polyethylene Glycol dimethylammonium | ????0.15 | ????0.15 | ????0.15 | ????0.15 | ????0.15 |
| Hexanediol | ????0.30 | ????0.30 | ????0.30 | ????0.30 | ????0.30 |
| Cocoamidopropyl | ????7.20 | ????7.20 | ????7.20 | ????7.20 | ????7.20 |
| Cocos nucifera oil acylamino-propyl group amine oxide | ????0.30 | ????0.30 | ????0.30 | ????0.30 | ????0.30 |
| polyquaternium-22 | ????2.00 | ????2.00 | ????2.00 | ????2.00 | ????2.00 |
| The Octopirox cholamine | ????-- | ????-- | ????-- | ????0.75 | ????0.75 |
| Total amount | ????100.00 | ????100.00 | ????100.00 | ????100.00 | ????100.00 |
Embodiment 2: preparation contains the shampoo base material of Dichlorobenzene base imidazo dioxolanes
Repeat embodiment 1 described method, different is to add 5 grams with the Dichlorobenzene base imidazo dioxolanes of trade name " Elubiol " available from Janssen Pharmaceutical N.V. in the mixture of pure water and ethylenic sodium sulfonate.
The mixture of gained was mixed about 40 minutes, till all solids dissolve basically.Add sodium citrate, protochloride oleoyl aminopropyl Polyethylene Glycol dimethylammonium and hexanediol then.The pH of gained mixture is about 7.With the citric acid of capacity with pH regulator to 4 about.The percetage by weight of used component is listed in the table 1 in the present embodiment.
Embodiment 3: preparation contains the shampoo base material of salicylic acid and Octopirox cholamine
Prepare water-ethylenic sodium sulfonate mixture by embodiment 1 described step, different is to use 440 gram pure water.
Under the condition that keeps constant internal temperature and pressure this mixture stirring after about 40 minutes, is being cooled to this mixture about 50 ℃.Under agitation in about 15 minutes, add the salicylic acid of 20 grams then, till all basically solids are dissolved available from SpectrumChemicals.Temperature and pressure remains unchanged.
Then " Phospholipid EFA " chemical compound and 3 grams hexylene glycol among 5 gram sodium citrates, the 5 gram embodiment 1 are stirred in this mixture.After under the condition that keeps constant internal temperature and pressure this mixture being stirred about 15 minutes, stir and add polyquaternium-22 used among " Standamox CAW " chemical compound used among " Chembetaine " surfactant used among the 240 gram embodiment 1, the 10 gram embodiment 1, the 20 gram embodiment 1 and 7.5 grams down with the Octopirox cholamine of trade name " Octopirox " available from Hoechst company.Under steady temperature and the pressure mixture restir of gained after 20 minutes, is being reduced to the temperature in this mixture about 35 ℃.The water that adds capacity then is to replenish the water that loses.The percetage by weight of used component is listed in the table 1 in the present embodiment.
Embodiment 4; Preparation contains the shampoo base material of Dichlorobenzene base imidazo dioxolanes, salicylic acid and Octopirox cholamine
Repeat embodiment 4 described steps, different is under agitation to add used Dichlorobenzene base imidazo dioxolanes among the 5 gram embodiment 2 in the mixture of pure water and ethylenic sodium sulfonate, be cooled to before 50 ℃ then, with the mixture restir of gained 40 minutes, till all basically solids are dissolved.
Embodiment 5: shampoo is to the minimal inhibitory concentration of pityrosporum ovale and Candida albicans
Shampoo among the research embodiment 1-5 and two kinds of commercially available contrast shampoos suppress five kinds of malassezia furfur ATCC numberings 42132,44337,44340,44342 and 44343 and the external activity of a kind of Candida albicans H29.The contrast shampoo " A " be the anti-dandruff shampoo that contains 0.5% coal tar, it with trade name " T-Gel " available from Neutrogena company.The contrast shampoo " B " be the anti-dandruff shampoo that contains 1% ketoconazole, it with trade name " the long-acting anti-dandruff shampoo of Neutrogena " available from Neutrogena company.
These shampoos directly are diluted to the culture medium (diagnostic sensitivity test agar (DST that has added Tween 80 (2 milliliters/liter) and monostearin (2.5 grams per liter); Oxoid, UK)) in, the concentration that makes shampoo in the culture medium is 0.1-40%.Therefore, minimal inhibitory concentration (MIC) value is for whole shampoo, rather than only for active component.Here used " MIC " is meant the least concentration of shampoo when observing whole inhibition growth of microorganism.
With 10
7Cells/ml (malassezia furfur) and 10
6The concentration of cells/ml (Candida albicans) adds microorganism on the plate that gelose medium is housed.Cultivate these plates at 37 ℃, and after 1,2 and 3 day, count.All shampoos are all tested twice.The results are shown in Table 2 for minimal inhibitory concentration.
Table 2: the minimal inhibitory concentration of shampoo among the embodiment 1-4
| Malassezia furfur ATCC421 32 | Malassezia furfur ATCC 44337 | Malassezia furfur ATCC 44340 | Malassezia furfur ATCC443 42 | Malassezia furfur ATCC 44343 | Candida albicans H29 | |
| Embodiment 1: the shampoo base material | ??1％ | ??1％ | ??2.5％ | ??1％ | ??2.5％ | ??20％ |
| Base material during embodiment 2:pH4 and Dichlorobenzene base imidazo dioxolanes | ??0.1％ | ??0.1％ | ??0.5％ | ??0.1％ | ??0.5％ | ??0.1％ |
| Base material during embodiment 2:pH7 and Dichlorobenzene base imidazo dioxolanes | ??0.1％ | ??0.1％ | ??0.1％ | ??0.1％ | ??0.1％ | ??0.5％ |
| Embodiment 3: base material, salicylic acid and Octopirox cholamine | ??0.5％ | ??0.5％ | ??0.5％ | ??0.5％ | ??0.5％ | ??0.5％ |
| Embodiment 4: base material, Dichlorobenzene base imidazo dioxolanes, salicylic acid and Octopirox cholamine | ??0.1％ | ??0.1％ | ??0.1％ | ??0.1％ | ??0.1％ | ??0.5％ |
| Contrast A:T-Gel | ??2.5％ | ??2.5％ | ??2.5％ | ??2.5％ | ??2.5％ | ??10％ |
| Contrast B:1% ketoconazole | ??0.1％ | ??0.1％ | ??0.1％ | ??0.1％ | ??0.1％ | ??0.5％ |
As shown in table 2, we be surprised to find contain Dichlorobenzene base imidazo dioxolanes, Octopirox cholamine and salicylic shampoo (embodiment 4) suppress aspect the malassezia furfur growth effectiveness and the shampoo that contains ketoconazole (contrast B) quite, and be better than containing the shampoo (contrast A) of coal tar.
We also be surprised to find contain Dichlorobenzene base imidazoles dioxolanes/Octopirox cholamine/salicylic shampoo (embodiment 4) suppress aspect the albicans growth effectiveness and the shampoo that contains ketoconazole (contrast B) quite, and be better than containing the shampoo (contrast A) of coal tar.
In a word, clearly, the shampoo that contains Dichlorobenzene base imidazo dioxolanes, it is more much effective than other commercially available shampoo aspect inhibition malassezia furfur and albicans growth particularly to contain Dichlorobenzene base imidazo dioxolanes/Octopirox cholamine/salicylic shampoo (embodiment 4).
Embodiment 6: shampoo is to the minimal inhibitory concentration of malassezia furfur
The external activity that shampoo among the research embodiment 5 and another kind of commercially available contrast shampoo suppress 29 kinds of malassezia furfurs.The contrast shampoo " C " be the anti-dandruff shampoo that contains 2% ketoconazole, it with trade name " Nizoral " available from Janssen Pharmaceutica N.V. company.These shampoos with 50 times of disinfectant dilutions, are further diluted with disinfectant by the double strength grade then, produce a series of diluents.
To collect 29 kinds of malassezia furfur yeast separation things that obtain from the crowd who is with or without the dandruff or seborrheic dermatitis cultivates in modification Dixon agar.By 1 liter of distilled water, this agar contain 36 grams available from the Fructus Hordei Germinatus extracts of Difco Laboratories, 6 grams available from Unipath, the Oxoid fungus peptone of Ltd, 20 grams available from the bacto-oxgall of Difco Laboratories, 10 milliliters with trade name " Tween 40 " available from the polyoxyethylene sorbitan carboxylic ester (polysorbate 40) of ICI Americas company, 2.5 milliliters of glycerol and 20 gram agar.Dixon meat soup is identical with its composition, but does not contain agar.
In the time of 30 ℃, these yeast were placed in the teat glass that Dixon meat soup and sterilization glass bead are housed (diameter=13 millimeter) growth then 2 days, and by 20 rev/mins speed rotating and culturing thing, preparation inoculum.By the adding disinfectant these suspensions being normalized to 530 nanometers optical density (OD)s is 1.0.Optical density (OD) UV-160A Shimadzu spectrophotometer measurement, light path is 1 centimetre.
Add 33 times of diluents of 50 microlitre gained inoculum suspensions in every kind of test of 50 microlitres in being placed on flat plastics Microdilution plate shampoo diluent, this produces the final shampoo diluent series since 1: 100.
In the time of 30 ℃ the culture of gained is placed on and cultivates in the incubator after 4 days, measure the optical density (OD) in these ponds with the biological automatic plate readers of radiation of 3550 types that are set in 570 nanometers (Bio-Rad automatic plate reader).Will be in the presence of the test shampoo growth (turbidity) of malassezia furfur be calculated as growth turbidity percent in the no medicine contrast pond of every kind of separator.The maximum of the product of malassezia furfur separator suppresses diluent and is defined as the high dilution that growth is reduced to the test shampoo below 50% of tester by the spectrophotometer reading.The maximum dilution factor that suppresses is listed in the table 3.
Table 3: the cumulative percentage of the separator of inhibition
| Dilution factor | Comparative Examples C | Embodiment 3 | Embodiment 4 | Embodiment 2 (high pH) | Embodiment 2 (low pH) | Embodiment 1 | The comparative example A | Comparative Examples B |
| ?3276800 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 |
| ?1638400 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 |
| ?819200 | ????0 | ????0 | ????0 | ????3 | ????0 | ????0 | ????0 | ????0 |
| ?409600 | ????0 | ????0 | ????0 | ????7 | ????3 | ????0 | ????0 | ????0 |
| ?204800 | ????24 | ????0 | ????41 | ????41 | ????59 | ????0 | ????0 | ????0 |
| ?102400 | ????59 | ????0 | ????100 | ????100 | ????93 | ????0 | ????0 | ????17 |
| ?51200 | ????100 | ????0 | ????100 | ????100 | ????100 | ????0 | ????0 | ????59 |
| ?25600 | ????100 | ????0 | ????100 | ????100 | ????100 | ????0 | ????0 | ????100 |
| ?12800 | ????100 | ????0 | ????100 | ????100 | ????100 | ????0 | ????0 | ????100 |
| ?6400 | ????100 | ????0 | ????100 | ????100 | ????100 | ????0 | ????0 | ????100 |
| ?3200 | ????100 | ????0 | ????100 | ????100 | ????100 | ????0 | ????0 | ????100 |
| ?1600 | ????100 | ????0 | ????100 | ????100 | ????100 | ????0 | ????0 | ????100 |
| ?800 | ????100 | ????3 | ????100 | ????100 | ????100 | ????0 | ????0 | ????100 |
| ?400 | ????100 | ????17 | ????100 | ????100 | ????100 | ????17 | ????0 | ????100 |
| ?200 | ????100 | ????100 | ????100 | ????100 | ????100 | ????86 | ????0 | ????100 |
| ?100 | ????100 | ????100 | ????100 | ????100 | ????100 | ????97 | ????97 | ????100 |
| ?＜100 | ????100 | ????100 | ????100 | ????100 | ????100 | ????100 | ????100 | ????100 |
| ?N＝ | ????29 | ????29 | ????29 | ????29 | ????29 | ????29 | ????29 | ????29 |
As shown in Table 3, three kinds of shampoos that contain Dichlorobenzene base imidazo dioxolanes have very strong inhibition activity to the malassezia furfur of live body outside, are to suppress 90% 2090 test separators at 1: 102400 o'clock at dilution factor.Present embodiment shows that the compositions that contains Dichlorobenzene base imidazo dioxolanes can suppress the growth of malassezia furfur effectively, and this microorganism it is believed that it is the cause of disease that causes hyperkeratotic dandruff disease.Therefore, the said composition prescription can be treated this disease effectively.
Embodiment 7: preparation is to the minimal inhibitory concentration of Propionibacterium
Prepare culture medium by embodiment 5 described steps, but use the preparation of Dichlorobenzene base imidazo dioxolanes in water, rather than use shampoo.
By about 10
7The concentration of cells/ml adds Propionibacterium being equipped with on the plate of gelose medium, by embodiment 5 described steps this plate is cultivated and reading then.Repeat present embodiment with other two kinds of different Propionibacteriums.
For two kinds of bacterial strains, the minimal inhibitory concentration of gained (it is the minimum Dichlorobenzene base imidazo dioxolanes concentration of observing in the present embodiment when suppressing growth of microorganism fully) is 1 mg/ml, and for the third bacterial strain, it is 10 mg/ml.Present embodiment shows that Dichlorobenzene base imidazo dioxolanes is active to suppressing the microbial growth relevant with the acne pathogeny.
Embodiment 8: to the contrast test of Elubiol, salicylic acid and benzoyl peroxide
Assign 107 adults (the 32%th, male, the age is 14-31 year, and has the acne of degree much at one) and use specified protective skin cream, every day twice, totally 12 weeks.About 1/3 people uses with the protective skin cream that contain 0.1%Elubiol (" E protective skin cream ") of trade name " BeBe Reinund Klar Gel " available from Penaten company; About 1/3 adult uses with trade name " CLEAN AND CLEAR Invisible Blemish Treatment " available from Johnson ﹠amp in addition; Johnson Consumer Companies, Inc.'s contains 2% salicylic protective skin cream (" SA protective skin cream "); And remaining adult uses with trade name " Clearasil Maximum Strength VanishingCream " available from Procter ﹠amp; The protective skin cream that contains 10% benzoyl peroxide of Gamble company (" BPO protective skin cream ").
Before the treatment beginning, the beginning (baseline) of counting each adult definitely damages number, promptly total blackhead, opening blackhead, the blackhead of remaining silent, pimple, pustule, cyst and nodular number.According to the grade of beginning acne symptom (be oiliness, erythema, dryness, decortication, inflammation, twinge, itch and air impermeability) to each qualitative definite one 0 (not having)-3 (seriously) of adult.According to beginning acne degree (being I level (blackhead acne), II level (pimple and pustule acne) or III level (acne conglobata)) to everyone further classification.During beginning, all adults are categorized as to have II level acne and has essentially identical acne symptom.After treating for 1,2,4,8 and 12 weeks in this way, recomputate each adult's absolute infringement number, acne symptom and acne degree.
After the treatment beginning, with respect to beginning, all adults' blackhead sum obviously descends.Use one group of the BPO protective skin cream to descend the most soon, 2 week back declines 46%.After 2 weeks, also descended 8% with a group of E protective skin cream treatment, and one group the blackhead number for the treatment of with the SA protective skin cream has only descended 2%.
After 12 weeks, with one group blackhead decreased number of BPO protective skin cream treatment 67%, and two groups for the treatment of with E protective skin cream and SA protective skin cream have reduced 36% and 37% respectively.The opening or the blackhead of remaining silent are observed similar result.
Present embodiment shows, preventing and treating aspect the blackhead, and the protective skin cream ratio that contains 10% benzoyl peroxide contains 1%elubiol or 2% salicylic protective skin cream has faster and more significant effect.Present embodiment shows that also elubiol has quicker curative effect than salicylic acid.
The protective skin cream that contains 10% benzoyl peroxide also has the fastest and more significant curative effect aspect the pimple preventing and treating.For the user of BPO protective skin cream, damaged decreased number at last 2/3, and in addition two groups only reduced 1/3.On one's body all these adults, seldom see pustule, cyst and tuberosity.
In one week of treatment beginning, use the BPO protective skin cream one group, oiliness has reduced 75%, and the oiliness of E protective skin cream user has reduced 55%, and SA protective skin cream user oiliness has reduced 35%.When 12 all treatments phases finished, one group the oiliness for the treatment of with elubiol had reduced 73%, and reduced 51% and 71% respectively with two groups oiliness of salicylic acid and benzoyl peroxide treatment.
In 1 week of treatment beginning, the erythema that elubiol is a group has reduced 39%, and the erythema of one group of salicylic acid has reduced 30%, and the erythema that benzoyl peroxide is a group has increased by 13%.12 weeks are when finishing, and the erythema in three groups has reduced 48%, 48% and 55% respectively.Present embodiment shows, and begins to compare, and only rises in first week with the patient of elubiol treatment and obviously reduced erythema.
In the last fortnight of treatment, it is all more obvious that each forms people's stimulation scar.After initial two weeks, the sx of stimulation.When 12 weeks finished, one group of stimulation (0/3.0) that shows minimum level of elubiol, and salicylic acid one group (0.3/3.0) and benzoyl peroxide one group (0.38/3.0) have tangible stimulation.Present embodiment shows in one group of benzoyl peroxide observes maximum stimulation, is followed successively by one group of one group of salicylic acid and elubiol.
Also use identical serious grade evaluation dryness and decortication.Specifically, one group of benzoyl peroxide than one group of one group of salicylic acid or elubiol show degree serious the dryness and the decortication of Duoing.
Twinge can not prove the problem relevant with user, in to 3 groups research process, itches and has all improved.Observing the fastest itching in a group of use E protective skin cream alleviates.
During beginning, the skin air impermeability does not become very big problem, but the inherent obvious variation of air impermeability of using skin in a group of BPO protective skin cream during the first week treatment.
In a word, present embodiment shows, it is faster that the protective skin cream ratio that contains 0.1%elubiol contains 2% salicylic protective skin cream effect, and more effective.And the protective skin cream that contains 0.1%elubiol is fast not as the protective skin cream effect that contains 10% benzoyl peroxide.By contrast, the elubiol protective skin cream has minimum side effect, and is accepted by user better than benzoyl peroxide protective skin cream generally.
Claims (40)
1. a treatment seborrheic dermatitis, the dandruff and psoriasic method is characterized in that this method comprises the steps:
A) on skin or hair, use the compositions that contains following component of effective dose:
1) Dichlorobenzene base imidazo dioxolanes; With
2) treatment component, it is selected from salicylic acid, coal tar and derivant thereof, Octopirox cholamine, selenium sulfide, Brafen or its mixture.
2. the method for claim 1 is characterized in that described treatment component is a salicylic acid.
3. method as claimed in claim 2 is characterized in that described treatment component also contains the Octopirox cholamine.
4. the method for claim 1 is characterized in that the consumption of described Dichlorobenzene base imidazo dioxolanes and treatment component can suppress fungi growth effectively.
5. the method for claim 1 is characterized in that the gross weight by compositions, and the consumption of described Dichlorobenzene base imidazo dioxolanes is 0.25-2%, and the consumption of described treatment component is 0.5-3%.
6. compositions is characterized in that it contains following component:
A) Dichlorobenzene base imidazo dioxolanes; With
B) treatment component, it is selected from salicylic acid, coal tar and derivant thereof, Octopirox cholamine, selenium sulfide, Brafen or its mixture.
7. compositions as claimed in claim 6 is characterized in that described treatment component is a salicylic acid.
8. compositions as claimed in claim 7 is characterized in that it also contains the Octopirox cholamine.
9. compositions as claimed in claim 6 is characterized in that the consumption of described Dichlorobenzene base imidazo dioxolanes and treatment component can suppress to produce mutual potentiation effectively aspect the dermatophytes growth.
10. compositions as claimed in claim 6 is characterized in that the gross weight by compositions, and the consumption of described Dichlorobenzene base imidazo dioxolanes is 0.25-2%, and the consumption of described treatment component is 0.5-3%.
11. goods is characterized in that it contains the described compositions of claim 6.
12. goods as claimed in claim 11 is characterized in that it is a shampoo.
13. goods as claimed in claim 11 is characterized in that it also contains one or more following components:
A.) at least a surfactant;
B.) foaming agent;
C.) being enough under the room temperature make the viscosity of final preparation is the thickening agent of 4000-9000mPa.s;
D.) antiseptic;
E.) antioxidant; And
F.) being enough to make the pH scope of shampoo is acid or alkali or the buffer agent of 3-8.
14. goods as claimed in claim 11, it is characterized in that it also contains one or more surfactants, this surfactant is selected from the C14-16 ethylenic sodium sulfonate, sodium lauryl sulphate, lauryl (polyoxyethylene) ether sodium sulfate, cocos nucifera oil acylamino-propyl group amine oxide, the oxidation lauryl amine, lauroyl diethanolamine, cocoamidopropyl, the lauryl dimethyl betanin, the cocoyl dimethyl sulfopropyl betaine, the cocoyl sodium sarcosinate, the amino MIPA sulfo-succinic acid of oleoyl disodium, cocos nucifera oil acylamino-MIPA sulfo-succinic acid disodium, lauryl (polyoxyethylene) ether sulfo-succinic acid disodium, cocoyl both sexes carboxyl glycinate, the amino monoethanolamine sulfo-succinic acid of oleoyl disodium, glycine amine, propanoic acid amine and amine sulfobetaines, and their mixture.
15. goods as claimed in claim 11 is characterized in that described surfactant contains 4-12% anion surfactant and 3-10% amphoteric surfactant.
16. goods as claimed in claim 11, it is characterized in that described anion surfactant comprises ethylenic sodium sulfonate, sodium lauryl sulphate, lauryl (polyoxyethylene) ether sodium sulfate or their mixture, described amphoteric surfactant comprises cocos nucifera oil acylamino-propyl group amine oxide, cocoamidopropyl or their mixture.
17. goods as claimed in claim 11 is characterized in that described foaming agent is selected from fatty acid list or two alkanolamides, it is selected from cocos nucifera oil acyl monoethanolamine, cocos nucifera oil acyl diethanolamine, oleoyl monoethanolamine, oleoyl diethanolamine and their mixture.
18. goods as claimed in claim 11; it is characterized in that described antioxidant is Yoshinox BHT, butylatedhydroxyanisole, ascorbic acid, N-acetylcysteine, sodium metabisulfite or their mixture; by the gross weight of shampoo, its consumption is 0.01-1%.
19. goods as claimed in claim 11 is characterized in that it also contains conditioner.
20. goods as claimed in claim 11 is characterized in that it also contains one or more pearling agents, this pearling agent is selected from glycol distearate, ethylene glycol monostearate and their mixture.
21. goods is characterized in that it contains the described compositions of claim 7.
22. goods is characterized in that it contains the described compositions of claim 8.
23. the preparation method of health and hair cleaning formulation is characterized in that this method comprises the steps:
(a) be enough to form mixed anion surfactant and deionized water under the condition of first mixture;
(b) Dichlorobenzene base imidazo dioxolanes and antioxidant are mixed with described first mixture being enough to form under the condition of second mixture;
(c) before adding the treatment component, second mixture is cooled to enough temperature;
(d) described treatment component is mixed with described refrigerative second mixture being enough to form under the condition of the 3rd mixture;
(e) buffer agent and amphoteric surfactant are mixed with described the 3rd mixture being enough to form under the condition of 4 mixture.
24. method as claimed in claim 23 is characterized in that described anion surfactant comprises ethylenic sodium sulfonate, sodium lauryl sulphate, lauryl (polyoxyethylene) ether sodium sulfate or their mixture.
25. method as claimed in claim 23 is characterized in that described amphoteric surfactant is cocos nucifera oil acylamino-propyl group amine oxide or its mixture.
26. method as claimed in claim 23 is characterized in that described treatment component is a salicylic acid.
27. method as claimed in claim 26 is characterized in that it also is included in adding Octopirox cholamine in described the 3rd mixture.
28. method as claimed in claim 23 is characterized in that it also comprises the described 4 mixture of cooling.
29. method as claimed in claim 28 is characterized in that it also is included under the condition of the 4 mixture that is enough to form conditioning conditioner is joined in the described 4 mixture.
30. method as claimed in claim 23 is characterized in that it also is included in and adds second kind of amphoteric surfactant in the 4 mixture of conditioning.
31. method as claimed in claim 30 is characterized in that described second kind of amphoteric surfactant is cocoamidopropyl or its mixture.
32. a method that suppresses bacterial growth on the skin surface is characterized in that this method comprises the steps:
The compositions that contains Dichlorobenzene base imidazo dioxolanes of local application effective dose on skin.
33. method as claimed in claim 32 is characterized in that described compositions also contains the treatment component, this treatment component is selected from salicylic acid, coal tar and derivant thereof, Octopirox cholamine, selenium sulfide, Brafen or its mixture.
34. a method for the treatment of acne, tinea capitis and tinea corporis is characterized in that this method comprises the steps:
The compositions that contains Dichlorobenzene base imidazo dioxolanes of local application effective dose on skin.
35. method as claimed in claim 34 is characterized in that this method is used for the treatment of acne.
36. method as claimed in claim 35 is characterized in that the gross weight by compositions, said composition contains 0.1-2% Dichlorobenzene base imidazo dioxolanes.
38. method as claimed in claim 35 is characterized in that described compositions also contains salicylic acid.
39. method as claimed in claim 38 is characterized in that Dichlorobenzene base imidazo dioxolanes and salicylic weight ratio are 0.5 in described compositions: 2.0-1: 1.
40. method of alleviating following one or more symptoms of skin or scalp: itch, rubescent or erythema, it is characterized in that this method comprises the steps:
The compositions that contains Dichlorobenzene base imidazo dioxolanes of local application effective dose on skin.
41. method as claimed in claim 40 is characterized in that described compositions also contains salicylic acid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5141897P | 1997-07-02 | 1997-07-02 | |
| US60/051,418 | 1997-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1262611A true CN1262611A (en) | 2000-08-09 |
Family
ID=21971188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98806837A Pending CN1262611A (en) | 1997-07-02 | 1998-06-29 | Methods for using compositions containing dichlorophenyl imidazoldioxolan to treat sebcrrheic dermatitis, dandruff, psoriasis, and acne, and compositions thereof |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0996410A1 (en) |
| JP (1) | JP2002510292A (en) |
| KR (1) | KR20010020598A (en) |
| CN (1) | CN1262611A (en) |
| AR (1) | AR013163A1 (en) |
| AU (1) | AU8270798A (en) |
| BR (1) | BR9810396A (en) |
| CA (1) | CA2294804A1 (en) |
| CO (1) | CO4940366A1 (en) |
| DE (1) | DE19880535T1 (en) |
| WO (1) | WO1998052518A1 (en) |
| ZA (1) | ZA985781B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112603861A (en) * | 2021-01-14 | 2021-04-06 | 澳美制药厂有限公司 | Head detergent and preparation method thereof |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696053B1 (en) * | 2000-05-04 | 2004-02-24 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Leave-on or rinse-out hair care conditioner compositions containing silicone quaternary compounds and thickeners |
| WO2003059297A2 (en) * | 2002-01-21 | 2003-07-24 | Slovakofarma A.S. | Dermatological topical compositions and a process for the preparation thereof |
| ITMI20020756A1 (en) * | 2002-04-09 | 2003-10-09 | Sinclair Pharma S R L | TOPICAL PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DERMATITIS |
| DE10253591A1 (en) * | 2002-11-15 | 2004-05-27 | Basf Ag | Use of polymers of basic amino group-containing monomers, e.g. N-vinyl-imidazole, as additives for cosmetic, dermatological or pharmaceutical formulations, especially delayed-release salicylic acid preparations |
| EP1675586A4 (en) * | 2003-10-20 | 2008-10-08 | Barrier Therapeutics Inc | Methods for treating non-microbial inflammatory skin conditions |
| CN101820877B (en) * | 2007-08-27 | 2013-09-11 | 日本农药株式会社 | Agent for fungal dermatitis |
| JP5615515B2 (en) * | 2009-05-26 | 2014-10-29 | 持田製薬株式会社 | Cleaning composition |
| WO2015040637A1 (en) * | 2013-09-19 | 2015-03-26 | MITTAL, Aman | Improved coal tar formulation for treatment of dandruff and other scalp diseases and its method of preparation thereof |
| PL3421093T3 (en) * | 2017-06-27 | 2021-03-08 | Daxxin AB | Liquid composition for wash of scalp and hair, or for wash of skin comprising piroctone olamine |
| US20220011478A1 (en) | 2020-07-09 | 2022-01-13 | Corning Incorporated | Textured region of a substrate to reduce specular reflectance incorporating surface features with an elliptical perimeter or segments thereof, and method of making the same |
| CN112263499B (en) * | 2020-11-27 | 2023-05-23 | 佛山市南海东方澳龙制药有限公司 | Animal flavor wave with antibacterial function and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4144346A (en) * | 1977-01-31 | 1979-03-13 | Janssen Pharmaceutica N.V. | Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| DK0630228T3 (en) * | 1992-03-20 | 1998-06-02 | Janssen Pharmaceutica Nv | Means for regulating skin fatness |
| US5456851A (en) * | 1994-04-07 | 1995-10-10 | Johnson & Johnson Consumer Products, Inc. | Ketoconazole shampoo containing butylated hydroxytoluene or butylated hydroxyanisole |
| TW449485B (en) * | 1995-03-31 | 2001-08-11 | Colgate Palmolive Co | Skin care products containing anti itching/anti irritant agents |
| NZ331380A (en) * | 1996-02-16 | 1999-06-29 | Janssen Pharmaceutica Nv | Body or hair cleansing compositions containing a pyrithione salt and ketoconazole or elubiol |
-
1998
- 1998-06-29 DE DE19880535T patent/DE19880535T1/en not_active Withdrawn
- 1998-06-29 WO PCT/US1998/013425 patent/WO1998052518A1/en not_active Application Discontinuation
- 1998-06-29 KR KR1019997012584A patent/KR20010020598A/en not_active Application Discontinuation
- 1998-06-29 AU AU82707/98A patent/AU8270798A/en not_active Abandoned
- 1998-06-29 CN CN98806837A patent/CN1262611A/en active Pending
- 1998-06-29 JP JP55076098A patent/JP2002510292A/en active Pending
- 1998-06-29 CA CA002294804A patent/CA2294804A1/en not_active Abandoned
- 1998-06-29 EP EP98932927A patent/EP0996410A1/en not_active Withdrawn
- 1998-06-29 BR BR9810396-2A patent/BR9810396A/en not_active Application Discontinuation
- 1998-07-01 AR ARP980103206A patent/AR013163A1/en unknown
- 1998-07-01 ZA ZA9805781A patent/ZA985781B/en unknown
- 1998-07-02 CO CO98037373A patent/CO4940366A1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112603861A (en) * | 2021-01-14 | 2021-04-06 | 澳美制药厂有限公司 | Head detergent and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA985781B (en) | 2000-01-10 |
| CA2294804A1 (en) | 1998-11-26 |
| WO1998052518A1 (en) | 1998-11-26 |
| EP0996410A1 (en) | 2000-05-03 |
| JP2002510292A (en) | 2002-04-02 |
| DE19880535T1 (en) | 1999-04-29 |
| KR20010020598A (en) | 2001-03-15 |
| AU8270798A (en) | 1998-12-11 |
| AR013163A1 (en) | 2000-12-13 |
| CO4940366A1 (en) | 2000-07-24 |
| BR9810396A (en) | 2000-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1165287C (en) | Compositions contg. antifungal and cationic agent | |
| CN1117558C (en) | Compositions containing an antifungal and a sulfur compound | |
| CN1245939C (en) | Non-spherical and non-platelet pyrithione salts | |
| CN1262611A (en) | Methods for using compositions containing dichlorophenyl imidazoldioxolan to treat sebcrrheic dermatitis, dandruff, psoriasis, and acne, and compositions thereof | |
| CN1074277C (en) | Liquid cleaning formulations for skin | |
| CN107349122A (en) | A kind of desquamation compositions and its application | |
| CN1036882A (en) | Synergistic biocidal composition | |
| CN1155359C (en) | Compositions contg. antifungal and phospholipid | |
| CN1728980A (en) | Scalp treatment | |
| CN114533586A (en) | Dandruff-removing itching-relieving shampoo composition, and preparation method and application thereof | |
| CN110960434A (en) | Scalp care shampoo composition and preparation method thereof | |
| CN1272362A (en) | Selective antibiotic composition | |
| CN113425624A (en) | Anti-dandruff oil control composition and preparation method and application thereof | |
| JPH10151468A (en) | Water with lowered surface tension and utilization thereof | |
| CN1167411C (en) | Skin cleaning method for eliminating comedones and scales from parts of skin subjected to proliferation of i(candida Alibicans) | |
| CN1221523C (en) | Novel di-quaternary ammonium salt compound | |
| CN1684662A (en) | Cleansing composition containing antifungal agent and antibacterial agent | |
| US20200323760A1 (en) | An antimicrobial cleansing composition | |
| CN110075022A (en) | A kind of anti-acne essence and preparation method thereof | |
| CN109172494A (en) | A kind of aloe shampoo and its preparation process of sterilizing and itch-relieving | |
| CN115569105A (en) | Composition containing rice hull extract for removing dandruff, controlling oil, inhibiting bacteria and removing mites | |
| JP6900375B2 (en) | Hair care composition | |
| CN112076111A (en) | Dandruff-removing shampoo composition | |
| CN111437208A (en) | Scalp hair cleansing composition, scalp care product, and scalp care method | |
| CN113797111B (en) | Composition for removing dandruff and preventing alopecia and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1051869 Country of ref document: HK |