CN112601745A - 一种氮杂芳基酰胺衍生物及其制备方法和应用 - Google Patents

一种氮杂芳基酰胺衍生物及其制备方法和应用 Download PDF

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Publication number
CN112601745A
CN112601745A CN201980055929.5A CN201980055929A CN112601745A CN 112601745 A CN112601745 A CN 112601745A CN 201980055929 A CN201980055929 A CN 201980055929A CN 112601745 A CN112601745 A CN 112601745A
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deuterium
cycloalkyl
cyano
alkyl radical
substituted
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CN112601745B (zh
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赵保卫
寻国良
危明松
张鸣鸣
杨舒群
喻红平
陈椎
徐耀昌
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Abbisko Therapeutics Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

提供一种具有式(I)结构的氮杂芳基酰胺衍生物及其制备方法和应用，各取代基的定义如说明书和权利要求书所述，该系列化合物可广泛应用于制备治疗一种或多种肿瘤、癌症、代谢性疾病、自身免疫性疾病或紊乱的药物，有望开发成新一代RORγt激动剂药物。

Description

PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN201980055929.5A 2018-10-24 2019-09-09 一种氮杂芳基酰胺衍生物及其制备方法和应用 Active CN112601745B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018112422515 2018-10-24
CN201811242251 2018-10-24
PCT/CN2019/104957 WO2020082921A1 (zh) 2018-10-24 2019-09-09 一种氮杂芳基酰胺衍生物及其制备方法和应用

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CN112601745A true CN112601745A (zh) 2021-04-02
CN112601745B CN112601745B (zh) 2023-06-27

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WO (1) WO2020082921A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113717353A (zh) * 2021-08-27 2021-11-30 徐州工程学院 一种双氮杂晕苯二酰亚胺n-型聚合物及其制备方法和用途
CN115322128A (zh) * 2022-08-05 2022-11-11 南京师范大学 一种基于烷基卤代物合成C(sp3)-S键的有机硫化合物及其制备方法与应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013019682A1 (en) * 2011-07-29 2013-02-07 Tempero Pharmaceuticals, Inc. Compounds and methods
CN103384668A (zh) * 2010-09-03 2013-11-06 福马Tm有限责任公司 用于抑制nampt的新化合物和组合物
WO2017132432A1 (en) * 2016-01-29 2017-08-03 Vitae Pharmaceuticals, Inc. Benzimidazole derivatives as modulators of ror-gamma
US20170260180A1 (en) * 2014-02-03 2017-09-14 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ror-gamma
CN108463458A (zh) * 2015-11-20 2018-08-28 生命医药公司 ROR-γ的调节剂

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103384668A (zh) * 2010-09-03 2013-11-06 福马Tm有限责任公司 用于抑制nampt的新化合物和组合物
WO2013019682A1 (en) * 2011-07-29 2013-02-07 Tempero Pharmaceuticals, Inc. Compounds and methods
US20170260180A1 (en) * 2014-02-03 2017-09-14 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ror-gamma
CN108463458A (zh) * 2015-11-20 2018-08-28 生命医药公司 ROR-γ的调节剂
WO2017132432A1 (en) * 2016-01-29 2017-08-03 Vitae Pharmaceuticals, Inc. Benzimidazole derivatives as modulators of ror-gamma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REGSTRY: ""CAS RN"" *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113717353A (zh) * 2021-08-27 2021-11-30 徐州工程学院 一种双氮杂晕苯二酰亚胺n-型聚合物及其制备方法和用途
CN113717353B (zh) * 2021-08-27 2023-07-25 徐州工程学院 一种双氮杂晕苯二酰亚胺n-型聚合物及其制备方法和用途
CN115322128A (zh) * 2022-08-05 2022-11-11 南京师范大学 一种基于烷基卤代物合成C(sp3)-S键的有机硫化合物及其制备方法与应用

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CN112601745B (zh) 2023-06-27

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