CN111886219A - 免疫抑制剂及其制备方法和在药学上的应用 - Google Patents

免疫抑制剂及其制备方法和在药学上的应用 Download PDF

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CN111886219A
CN111886219A CN201980020074.2A CN201980020074A CN111886219A CN 111886219 A CN111886219 A CN 111886219A CN 201980020074 A CN201980020074 A CN 201980020074A CN 111886219 A CN111886219 A CN 111886219A
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deuterium
substituted
radical
membered
cycloalkyl
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CN111886219B (zh
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张鸣鸣
张永贤
喻红平
陈椎
徐耀昌
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Abbisko Therapeutics Co Ltd
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

一种式(Ⅰ)结构免疫抑制剂及其制备方法和在药学上的应用。系列化合物具有对PD‑1/PD‑L1相互作用有很强的抑制活性，可广泛应用于制备预防和/或治疗由PD‑1/PD‑L1信号通路介导的癌症或肿瘤、免疫相关疾病及紊乱、传染性疾病、感染性疾病或代谢性疾病的药物，有望开发成新一代PD‑1/PD‑L1抑制剂。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN201980020074.2A 2018-07-11 2019-07-10 免疫抑制剂及其制备方法和在药学上的应用 Active CN111886219B (zh)

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CN2018107600118 2018-07-11
CN201810760011 2018-07-11
CN201910069224 2019-01-24
CN2019100692240 2019-01-24
PCT/CN2019/095461 WO2020011209A1 (zh) 2018-07-11 2019-07-10 免疫抑制剂及其制备方法和在药学上的应用

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113461668A (zh) * 2021-04-30 2021-10-01 西安新通药物研究股份有限公司 一种新型联苯类衍生物及其制备方法与医药用途
CN115232125A (zh) * 2021-05-14 2022-10-25 杭州和正医药有限公司 多取代苯类免疫调节化合物、组合物及其应用
CN115925697A (zh) * 2021-08-24 2023-04-07 昆药集团股份有限公司 一种小分子免疫调节抑制剂及其药物组合和用途

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AU2017289038B2 (en) 2016-06-27 2021-07-22 Chemocentryx, Inc. Immunomodulator compounds
US11130740B2 (en) 2017-04-25 2021-09-28 Arbutus Biopharma Corporation Substituted 2,3-dihydro-1H-indene analogs and methods using same
CA3070794A1 (en) 2017-07-28 2019-01-31 Chemocentryx, Inc. Immunomodulator compounds
EP3664793B1 (en) 2017-08-08 2022-06-29 ChemoCentryx, Inc. Macrocyclic immunomodulators
WO2019165043A2 (en) 2018-02-22 2019-08-29 Chemocentryx, Inc. Indane-amines as pd-l1 antagonists
CA3093851A1 (en) 2018-03-29 2019-10-03 Arbutus Biopharma Corporation Substituted 1,1'-biphenyl compounds, analogues thereof, and methods using same
JP2022531970A (ja) 2019-05-15 2022-07-12 ケモセントリックス，インコーポレイティド Ｐｄ－ｌ１疾患治療用のトリアリール化合物
MA55325A (fr) 2019-06-20 2022-04-27 Chemocentryx Inc Composés pour le traitement de maladies pd-l1
KR20220034829A (ko) 2019-07-10 2022-03-18 케모센트릭스, 인크. Pd-l1 억제제로서의 인단
BR112022006018A2 (pt) 2019-10-16 2022-07-12 Chemocentryx Inc Heteroaril-bifenil amidas para o tratamento de doenças relacionadas à pd-l1
CA3152714A1 (en) 2019-10-16 2021-04-22 Pingchen Fan Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases
EP4089091A4 (en) 2020-01-07 2024-03-20 Abbisko Therapeutics Co., Ltd. DOUBLE BONDED BIPHENYL FLUORINE DERIVATIVE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF
CA3182595A1 (en) * 2020-06-17 2021-12-23 Mingming Zhang Immunosuppressant, and preparation method therefor and use thereof
CN114075123B (zh) * 2020-08-11 2023-06-06 中国人民解放军军事科学院军事医学研究院 苄胺类衍生物及其制备方法与用途
WO2022257833A1 (zh) * 2021-06-07 2022-12-15 上海海雁医药科技有限公司 取代的苯基丙烯基吡啶类衍生物中间体及其制备方法
CA3240346A1 (en) * 2021-12-16 2023-06-22 Aligos Therapeutics, Inc. Methods and compositions for targeting pd-l1
CN114315787A (zh) * 2021-12-30 2022-04-12 广州佳途科技股份有限公司 一种维兰特罗ep杂质2的制备方法及应用

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113461668A (zh) * 2021-04-30 2021-10-01 西安新通药物研究股份有限公司 一种新型联苯类衍生物及其制备方法与医药用途
CN113461668B (zh) * 2021-04-30 2022-12-09 西安新通药物研究股份有限公司 一种新型联苯类衍生物及其制备方法与医药用途
CN115232125A (zh) * 2021-05-14 2022-10-25 杭州和正医药有限公司 多取代苯类免疫调节化合物、组合物及其应用
CN115925697A (zh) * 2021-08-24 2023-04-07 昆药集团股份有限公司 一种小分子免疫调节抑制剂及其药物组合和用途

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WO2020011209A1 (zh) 2020-01-16
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