CN112592378A - 一种制备高纯度结晶塔格糖的方法 - Google Patents
一种制备高纯度结晶塔格糖的方法 Download PDFInfo
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- CN112592378A CN112592378A CN202110223481.2A CN202110223481A CN112592378A CN 112592378 A CN112592378 A CN 112592378A CN 202110223481 A CN202110223481 A CN 202110223481A CN 112592378 A CN112592378 A CN 112592378A
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- tagatose
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- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 title claims abstract description 119
- 238000000034 method Methods 0.000 title claims abstract description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 153
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- 238000006555 catalytic reaction Methods 0.000 claims abstract description 33
- 238000006243 chemical reaction Methods 0.000 claims abstract description 33
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- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 108010093096 Immobilized Enzymes Proteins 0.000 claims abstract description 7
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- 239000007791 liquid phase Substances 0.000 claims description 8
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- 125000002091 cationic group Chemical group 0.000 claims description 6
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- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 4
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- 238000005119 centrifugation Methods 0.000 claims description 2
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- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 3
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- VXLCNTLWWUDBSO-UHFFFAOYSA-N Ethiazide Chemical compound ClC1=C(S(N)(=O)=O)C=C2S(=O)(=O)NC(CC)NC2=C1 VXLCNTLWWUDBSO-UHFFFAOYSA-N 0.000 description 2
- 108010018080 L-arabinose isomerase Proteins 0.000 description 2
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- 238000002835 absorbance Methods 0.000 description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
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- 229960000856 protein c Drugs 0.000 description 2
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- LKDRXBCSQODPBY-OEXCPVAWSA-N D-tagatose Chemical compound OCC1(O)OC[C@@H](O)[C@H](O)[C@@H]1O LKDRXBCSQODPBY-OEXCPVAWSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
组分 | 反应液 | 中空纤维柱过滤后滤液 | 超滤透过液 | 回收率 |
塔格糖 | 59.2 g/L | 58.8 g/L | 56.9 g/L | 96.1% |
葡萄糖 | 3.01 g/L | 2.96 g/L | 2.84 g/L | 94.3% |
麦芽二糖 | 9.12 g/L | 8.97 g/L | 7.96 g/L | 87.3% |
无机盐<sup>a</sup> | 2110 μS/cm | 2108 μS/cm | 2105 μS/cm | - |
色素<sup>b</sup>(A<sub>430</sub>) | 1.146 | 0.348 | 0.086 | - |
蛋白<sup>c</sup> | 2.86 g/L | 1.59 g/L | 0 | - |
组分 | 反应液 | 陶瓷膜后滤液 | 超滤透过液 | 回收率 |
塔格糖 | 95.6 g/L | 94.3 g/L | 92.9 g/L | 97.2% |
葡萄糖 | 5.02 g/L | 4.92 g/L | 4.84 g/L | 96.4% |
麦芽二糖 | 25.4 g/L | 24.6 g/L | 22.9 g/L | 90.2% |
寡糖(DP≥3) | ~13 g/L | ~12 g/L | ~10 g/L | ~77% |
无机盐<sup>a</sup> | 2560 μS/cm | 2548 μS/cm | 2546 μS/cm | |
色素<sup>b</sup>(A<sub>430</sub>) | 1.343 | 0.726 | 0.102 | |
蛋白<sup>c</sup> | 2.86 g/L | 1.59 g/L | 0 |
Claims (10)
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114231579A (zh) * | 2022-01-13 | 2022-03-25 | 福州大学 | 一种连续、循环制备d-阿洛酮糖的方法 |
WO2023174422A1 (zh) * | 2022-03-18 | 2023-09-21 | 中国科学院天津工业生物技术研究所 | 高纯度结晶d-塔格糖,包含其的组合物,以及制备方法和用途 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102876752A (zh) * | 2012-09-07 | 2013-01-16 | 山东绿健生物技术有限公司 | 一种结晶塔格糖的生产方法 |
CN103992362A (zh) * | 2014-06-12 | 2014-08-20 | 黑龙江八一农垦大学 | 一种顺序式模拟移动色谱(ssmb)纯化塔格糖的方法 |
CN106399427A (zh) * | 2016-11-01 | 2017-02-15 | 中国科学院天津工业生物技术研究所 | 塔格糖的制备方法 |
CN107988286A (zh) * | 2016-11-02 | 2018-05-04 | 中国科学院天津工业生物技术研究所 | 一种全细胞催化制备塔格糖的方法 |
-
2021
- 2021-03-01 CN CN202110223481.2A patent/CN112592378B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102876752A (zh) * | 2012-09-07 | 2013-01-16 | 山东绿健生物技术有限公司 | 一种结晶塔格糖的生产方法 |
CN103992362A (zh) * | 2014-06-12 | 2014-08-20 | 黑龙江八一农垦大学 | 一种顺序式模拟移动色谱(ssmb)纯化塔格糖的方法 |
CN106399427A (zh) * | 2016-11-01 | 2017-02-15 | 中国科学院天津工业生物技术研究所 | 塔格糖的制备方法 |
CN107988286A (zh) * | 2016-11-02 | 2018-05-04 | 中国科学院天津工业生物技术研究所 | 一种全细胞催化制备塔格糖的方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114231579A (zh) * | 2022-01-13 | 2022-03-25 | 福州大学 | 一种连续、循环制备d-阿洛酮糖的方法 |
WO2023174422A1 (zh) * | 2022-03-18 | 2023-09-21 | 中国科学院天津工业生物技术研究所 | 高纯度结晶d-塔格糖,包含其的组合物,以及制备方法和用途 |
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