CN112587596A

CN112587596A - Pharmaceutical composition for treating lymphatic system diseases caused by deficiency fire phlegm stagnation

Info

Publication number: CN112587596A
Application number: CN202110024076.8A
Authority: CN
Inventors: 莫云; 伍松; 满其明; 李建兴; 邬厚丰
Original assignee: Chongqing Linbao Biotechnology Co ltd
Current assignee: Chongqing Linbao Biotechnology Co ltd
Priority date: 2021-01-08
Filing date: 2021-01-08
Publication date: 2021-04-02

Abstract

The invention discloses a pharmaceutical composition for treating lymphatic system diseases caused by deficiency fire phlegm stagnation. The pharmaceutical composition is a preparation prepared from the following raw material medicines in parts by weight: 280-320 parts of muskroot-like semiaquilegia root, 580-620 parts of selfheal, 430-470 parts of white cucumber, 230-270 parts of polygonum multiflorum, 180-220 parts of honeysuckle, 380-420 parts of lysimachia christinae hance, 80-120 parts of seaweed, 180-220 parts of tuber fleeceflower stem, 130-170 parts of schizonepeta, 180-220 parts of honeysuckle stem and 80-120 parts of akebia stem. The composition has excellent therapeutic effect on lymphatic system diseases (including lymphadenitis, lymphoid tuberculosis, and lymphoma) with syndrome of deficient fire and phlegm stagnation, and has high cure rate and low adverse side effect. The pharmaceutical composition has wide application prospect in preparing the medicine for preventing and/or treating the lymphatic system diseases of the deficiency fire phlegm accumulation syndrome.

Description

Pharmaceutical composition for treating lymphatic system diseases caused by deficiency fire phlegm stagnation

Technical Field

The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a pharmaceutical composition for treating lymphatic system diseases caused by deficiency fire phlegm stagnation.

Background

Scrofula, also known as "scrofula neck" or "mouse sore", is a disease of lymphatic system that originates from the neck. The name of scrofula is found in Lingshu, Cold and fever from Huangdi's internal classic two thousand years ago: scrofula due to cold or heat is characterized by that the axilla of the neck is surrounded by the small scrofula and the large scrofula, which are connected in series and are strung like beads. This disease is characterized by its early appearance like a bean, no pain, gradual increase, accumulation like a string of beads, skin color turning to dark red when forming pus, and pus being clear and thin after ulceration, which often heals to form sinus like a rat hole. Scrofula is a common chronic disease and also a most distressing disease, and greatly harms the physical health and life safety of patients.

Pathological causes of scrofula: according to the traditional Chinese medicine, the pathogenesis of the scrofula is mainly deficiency and secondary excess, and the deficiency refers to liver and kidney deficiency, or qi and blood deficiency, marrow and sea deficiency, and clear orifices and malnutrition. The excessive syndrome is the obstruction of the meridians by wind, fire and phlegm stasis. Clinical practice shows that scrofula is caused by deficiency of origin and excess of secondary aspect, and the pathogenesis of scrofula is mainly caused by deficiency of qi and blood, deficiency of liver-yin and kidney-yin, hyperactivity of liver-yang and bleeding and obstruction of collaterals. The syndrome of the excessive heat in the interior of the body can be caused by the stagnation of the sexual disorder and the beriberi, which leads to the excessive heat in the interior of the body and the fluid being transformed into phlegm, which then ascends to the neck. In the later stage of the disease, the liver is more exuberant, the lower fire is good at kidney yin, or the pus is dripping, and the qi and blood are wasted, so the disease is often transferred to the donation. In addition, the disease can also be caused by fire excess due to yin deficiency of lung and kidney, failure of lung fluids to distribute and burning fluids, phlegm fire coagulation.

Scrofula can be classified into: in the initial stage: the neck part has one or more than one kernel (such as semen glycines) which can appear simultaneously or sequentially, the skin color is unchanged, the texture is slightly hard, the surface is smooth, the neck part is not hot and does not have pain, and the neck part can move by pushing. In the middle stage: the nucleus masses are gradually enlarged and adhere to the epidermis, and sometimes several nucleus masses are fused into a large lump, which is unable to move and is painful. When suppuration further progresses, the superficial skin turns dark red, slightly hot, and has slight wave movement. And (3) later stage: the suppurative mass is cut or automatically broken, then clear and thin pus flows out to contain septicemia, the sore is a latent lumen (a cavity with thin surface skin and extending towards the periphery under the skin), the skin is grey, the skin around the sore is purple and dark, and sinus can be formed. If the pus thickens, the granulation turns bright red, indicating that healing is imminent.

According to the traditional Chinese medicine symptom type scrofula, the medicine can be divided into the following parts: syndrome of cold-phlegm stagnation, syndrome of qi stagnation and toxin stasis, syndrome of deficient fire with phlegm accumulation, syndrome of blood stasis and mass, syndrome of blood heat and wind dryness, syndrome of yin deficiency of liver and kidney, and syndrome of deficiency of both qi and blood. For scrofula with different syndrome types, it is necessary to treat the scrofula with different syndromes according to the differentiation of syndromes.

At present, the clinical treatment method for scrofula patients mostly adopts oral western medicine combined with injection medicine therapy, and has certain curative effect, but higher cost and certain side effect. Many patients are treated by antibiotics or antiviral infusion for one month, lymph nodes are not eliminated, and pain and various discomfort of lymph affected parts, poor immunity, inappetence, general weakness and the like sometimes occur. Therefore, there is a need to develop a natural Chinese medicine for treating scrofula with excellent curative effect and less adverse reactions and toxic and side effects.

Although chinese patent application CN107412358A describes a traditional Chinese medicine composition for treating lymphatic system diseases, this application does not describe the compatibility of the traditional Chinese medicine composition and does not describe the specific symptoms of lymphatic system diseases (such as lymphadenitis and scrofula) for which the traditional Chinese medicine composition is directed. As known to those skilled in the art, treatment based on syndrome differentiation is a process of diagnosing and treating diseases under the guidance of holistic concepts in traditional Chinese medicine, and includes two stages of syndrome differentiation and treatment. For the treatment of diseases in TCM, the treatment should be done by differentiation of syndromes. Therefore, the Chinese medicinal composition disclosed in the above patent application has no means at all for treating lymphatic system diseases (e.g., lymphadenitis, scrofula).

At present, no traditional Chinese medicine composition for treating lymphatic system diseases with syndrome of deficient fire and phlegm stagnation is reported.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition for treating lymphatic system diseases caused by deficiency fire phlegm accumulation with small side effect and high cure rate.

The invention provides a traditional Chinese medicine composition, which is a preparation prepared from the following raw material medicines in parts by weight: 280-320 parts of muskroot-like semiaquilegia root, 580-620 parts of selfheal, 430-470 parts of white cucumber, 230-270 parts of polygonum multiflorum, 180-220 parts of honeysuckle, 380-420 parts of lysimachia christinae hance, 80-120 parts of seaweed, 180-220 parts of tuber fleeceflower stem, 130-170 parts of schizonepeta, 180-220 parts of honeysuckle stem and 80-120 parts of akebia stem.

Further, the traditional Chinese medicine preparation is a preparation prepared from the following raw material medicines in parts by weight: 300 parts of muskroot-like semiaquilegia root, 600 parts of selfheal, 450 parts of white ground cucumber, 250 parts of tuber fleeceflower root, 200 parts of honeysuckle flower, 400 parts of rabdosia rubescens, 100 parts of seaweed, 200 parts of tuber fleeceflower stem, 150 parts of fineleaf schizonepeta herb, 200 parts of honeysuckle stem and 100 parts of akebia stem.

Furthermore, the traditional Chinese medicine composition is a preparation prepared by taking the traditional Chinese medicine composition as an active ingredient and adding pharmaceutically acceptable auxiliary ingredients.

Further, the formulation is an oral formulation.

Further, the oral preparation is decoction, oral liquid, granules, capsules, powder, pills or tablets.

The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:

(1) weighing the raw materials according to the weight ratio;

(2) preparing the medicinal powder of the raw material medicine, the water extract or the organic solvent extract of the raw material medicine, and adding pharmaceutically acceptable auxiliary components to obtain the traditional Chinese medicine.

Further, the method comprises the steps of:

(i) weighing radix semiaquilegiae, half of selfheal, white cucumber, polygonum multiflorum and honeysuckle, crushing and sieving to obtain powder;

(ii) weighing the rabdosia rubescens, the rest half of selfheal, seaweed, tuber fleeceflower stem, schizonepeta, honeysuckle stem and akebia stem, adding water for decoction, filtering, taking liquid, and concentrating to obtain concentrated solution;

(iii) and (3) uniformly mixing the powder obtained in the step (i) and the concentrated solution obtained in the step (ii), adding pharmaceutically acceptable auxiliary components, forming and drying to obtain the powder.

Further, in the step (i), the sieving is to pass through a sieve of 50-200 meshes, preferably a sieve of 100 meshes;

and/or in the step (ii), the weight ratio of the raw material medicine to the water is 1: 0.6 to 5.0, preferably 2.0 to 3.0; the decocting time is 1-2 hours; the decocting frequency is 1-2 times, and the decocting mode is decocting in a boiling state; the solid content of the concentrated solution is 10-20 wt.%.

The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for preventing and/or treating the lymphatic system diseases caused by the deficiency fire phlegm accumulation.

Further, the lymphatic system disease of the deficiency fire phlegm accumulation syndrome is lymphadenitis of the deficiency fire phlegm accumulation syndrome, scrofula of the deficiency fire phlegm accumulation syndrome or lymphoma of the deficiency fire phlegm accumulation syndrome.

White cucumber, the whole herb of Viola diffusa Ging, a plant of Violaceae, comes from Sichuan Bingxiao Yao (Chinese materia Medica), which is a alias of the white herb recorded in Tianbao Bencao, and is named as schefflera arboricola, cucumis sativus, Chinese cabbage and Conyza blinii.

Ling Bing Cao, the dry aerial parts of Ramosia rubescens (Hemsl) Hara of Labiatae, also known as Rabdosia rubescens.

Caulis Polygoni Multiflori, rattan of Polygonum multiflorum Thunb of Polygonaceae or rattan with leaves, also called caulis Polygoni Multiflori.

In the pharmaceutical composition, the selfheal has the effects of clearing liver and purging fire, improving eyesight, dissipating stagnation and relieving swelling, the white ground cucumber has the effects of clearing away heat and toxic materials and dissipating swelling quickly, and the Chinese medicines are monarch medicines together; tuber fleeceflower stem heart nourishing and nerve calming, vein relaxing, muskroot-like semiaquilegia root clearing away heat and toxic material, detumescence and stagnation elimination, tuber fleeceflower root bitter, sweet and astringent, mild warm, liver, heart and kidney meridian entered, seaweed dispels phlegm and soften hard lumps and dissipate stagnation, diuresis and detumescence, which are used as ministerial drugs together; herba Schizonepetae has effects in relieving exterior syndrome, dispelling pathogenic wind, promoting eruption, and eliminating sore as adjuvant drug; honeysuckle flower, honeysuckle stem, caulis lonicerae, caulis akebiae, fructus akebiae, herba clematidis, honeysuckle flower. The traditional Chinese medicine composition has obvious curative effect on lymphatic system diseases caused by deficiency fire phlegm accumulation syndrome by using all the medicines together.

Experimental results show that the pharmaceutical composition has excellent treatment effect on the lymphatic system diseases (including lymphadenitis, scrofula and lymphoma) with the syndrome of deficiency-fire phlegm stagnation, and has high cure rate and small toxic and side effects. The pharmaceutical composition has wide application prospect in preparing the medicine for preventing and/or treating the lymphatic system diseases of the deficiency fire phlegm accumulation syndrome.

Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.

The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.

Drawings

FIG. 1 is a photograph of case 1 before and after treatment; wherein a is a photograph after 15 days of administration, and the lymphoid tuberculosis is much smaller than that before administration; b is a picture after 30 days of administration, most of scrofula is eliminated, and the rehabilitation effect of the patient is good; c is a photograph taken 60 days after administration, and 4 lymphoid tuberculosis before administration have disappeared a lot; d is a photograph taken 80 days after administration, most lymphoid tuberculosis had disappeared, leaving only a small wound.

FIG. 2 is a photograph of case 2 before and after treatment; wherein a is a picture before administration, b is a picture after 1 day of administration, c is a picture after 15 days of administration, d is a picture after 25 days of administration, and e is a picture after 60 days of administration, most lymphoid tuberculosis of a patient disappears, and a ulcerated wound is completely healed.

FIG. 3 is a photograph of case 3 before and after treatment; wherein a is a picture before administration, b is a picture after 8 days of administration, and c is a picture after 3 months of administration, at this time, the skin of the patient has been restored to normal, and the scrofula is completely eradicated.

FIG. 4 is a photograph of case 4 before and after treatment; wherein a is a photograph before administration, b is a photograph after 10 days of administration, c is a photograph after 20 days of administration, d is a photograph after 30 days of administration, e is a photograph after 40 days of administration, f is a photograph after 50 days of administration, g is a photograph after 60 days of administration, h is a photograph after 80 days of administration, i is a photograph after 100 days of administration, j is a photograph after 120 days of administration, and k is a photograph after 150 days of administration, at which time substantially all wounds of the patient have healed, and the patient is recovering from normal skin in an effort.

FIG. 5 is a photograph of case 5 before and after treatment; wherein a is a picture before administration, b is a picture after 30 days of administration, it can be seen that lymph nodes on the neck of a patient are obviously improved, the neck has no rigid feeling, the scrofula is also eliminated, and the focus is reduced.

FIG. 6 is a photograph of case 6 before and after treatment; wherein a is a photograph before administration, b is a photograph after 10 days of administration,

c is a photograph taken 50 days after administration.

Fig. 7 is a CT examination report sheet before administration to case 7 patients.

Fig. 8 is a CT exam report after dosing of case 7 patients.

Detailed Description

The raw materials and equipment used in the invention are known products and are obtained by purchasing commercial products.

EXAMPLE 1 preparation of a pharmaceutical composition of the invention

1. Prescription

Composition a: 300g of muskroot-like semiaquilegia root, 300g of selfheal, 450g of white ground cucumber, 250g of polygonum multiflorum and 200g of honeysuckle;

composition b: 400g of Lingxicao, 300g of selfheal, 100g of seaweed, 200g of tuber fleeceflower stem, 150g of herba schizonepetae, 200g of honeysuckle stem and 100g of akebia stem.

2. Preparation method

(1) Weighing radix semiaquilegiae, selfheal, white rehmannia root, polygonum multiflorum and honeysuckle according to the prescription of the composition a, crushing, and sieving with a 100-mesh sieve to obtain powder;

(2) weighing the Chinese medicines of the composition b, namely the Linglingcao, the selfheal, the seaweed, the tuber fleeceflower stem, the schizonepeta, the honeysuckle stem and the akebia stem according to the prescription amount of the composition b, adding 2-3 times of water by weight, boiling with strong fire, boiling with slow fire for 1-2 hours, filtering, and collecting decoction; adding 2/3 times of water into the dregs, boiling with strong fire, decocting with slow fire for 1 hour, filtering to remove the dregs, combining the two decoctions, boiling with strong fire and concentrating to obtain a concentrated solution with the solid content of 10-20 wt.%.

(3) And (3) uniformly mixing the powder obtained in the step (1) and the concentrated solution obtained in the step (2), adding an adhesive commonly used in the field of traditional Chinese medicines, pelleting by a pelleting machine to obtain pills with the diameter of 5mm, and drying at 80-105 ℃ to obtain the pharmaceutical composition.

The beneficial effects of the preparation of the invention are demonstrated by the following experimental examples.

Experimental example 1 clinical case statistics of therapeutic effect of the pharmaceutical composition of the present invention on lymphadenitis

1. Diagnostic criteria of traditional Chinese medicine

Deficiency fire with accumulation of phlegm type lymphnoditis: there are many swollen nuclei in the neck, under the ear or under the armpit, which are not painful and itchy, the skin color is unchanged, dizziness and tinnitus, or bitter taste in the mouth and dry throat, or yellow and white phlegm, chest and abdominal distention, dry stool, scanty and brownish urine, red tongue with red, red fur and yellow, and wiry and rapid pulse. One or more swollen masses, such as those of soybeans, can appear simultaneously or sequentially, the skin color is unchanged, the mass is slightly hard, the surface is smooth, the swelling is not hot and does not cause pain, and the movement can be performed by pushing.

2. Standard of care

The standard of cure is as follows: the symptoms completely disappeared.

The effective standard is as follows: more than 80% of symptoms disappear.

3. Method of treatment

After the diagnosis is clear, the patient with the deficiency fire phlegm accumulation type lymphadenitis takes the pharmaceutical composition prepared in the embodiment 1 of the invention three times a day, the dosage is 14-15 g once for an adult, 8-10 g once for a 5-10 year old child, and 5-8 g once for a 2-5 year old child. The administration is continued for 1-2 months.

4. Therapeutic results

After 2000 patients with the deficiency fire phlegm accumulation type lymphadenitis take the pharmaceutical composition prepared in the embodiment 1 of the invention, the cure rate is 90%, and the effective rate is 99%.

Experimental example 2 clinical case statistics of the therapeutic effect of the pharmaceutical composition of the present invention on lymph node

1. Diagnostic criteria of traditional Chinese medicine

Lymphoid tuberculosis with syndrome of deficient fire and phlegm accumulation: there are many swollen nuclei in the neck, under the ear or under the armpit, which are not painful and itchy, the skin color is unchanged, dizziness and tinnitus, or bitter taste in the mouth and dry throat, or yellow and white phlegm, chest and abdominal distention, dry stool, scanty and brownish urine, red tongue with red, red fur and yellow, and wiry and rapid pulse. The nucleus and epidermis are adhered together, and sometimes several nuclei fuse into large lumps, which are immobilized and painful. When suppuration further progresses, the superficial skin turns dark red, slightly hot, and has slight wave movement.

2. Standard of care

The standard of cure is as follows: the symptoms completely disappeared.

The effective standard is as follows: more than 80% of symptoms disappear.

3. Method of treatment

After the diagnosis is clear, patients with lymphoid tuberculosis of deficiency fire phlegm accumulation syndrome take the pharmaceutical composition prepared in the example 1 of the invention three times a day, wherein the dosage is 18-20 g once for an adult, 8-10 g once for children of 5-10 years old, and 5-8 g once for children of 2-5 years old. The administration is continued for 1-4 months.

4. Therapeutic results

After 1000 patients with the lymphoid tuberculosis of the deficiency fire phlegm accumulation syndrome take the pharmaceutical composition prepared in the embodiment 1 of the invention, the cure rate is 95%, and the effective rate is 98%.

Experimental example 3 clinical case statistics of the therapeutic effect of the pharmaceutical composition of the present invention on lymphoma

1. Diagnostic criteria

Lymphoma of deficiency fire with phlegm accumulation: there are many swollen nuclei in the neck, under the ear or under the armpit, which are not painful and itchy, the skin color is unchanged, dizziness and tinnitus, or bitter taste in the mouth and dry throat, or yellow and white phlegm, chest and abdominal distention, dry stool, scanty and brownish urine, red tongue with red, red fur and yellow, and wiry and rapid pulse. The suppurative mass is cut or automatically broken, then clear and thin pus flows out to contain septicemia, the sore is a latent lumen (a cavity with thin surface skin and extending towards the periphery under the skin), the skin is grey, the skin around the sore is purple and dark, and sinus can be formed.

2. Standard of care

The standard of cure is as follows: the symptoms completely disappeared.

The effective standard is as follows: more than 80% of symptoms disappear.

3. Method of treatment

After the diagnosis is clear, patients with lymphoma of deficiency fire and phlegm accumulation syndrome take the pharmaceutical composition prepared in the embodiment 1 of the invention three times a day, wherein the dosage is 18-20 g once for an adult, 8-10 g once for children of 5-10 years old, and 5-8 g once for children of 2-5 years old. The administration is continued for 1-4 months.

4. Therapeutic results

200 patients with lymphoma of deficient fire with phlegm accumulation syndrome: 32 early stage lymphoma patients are cured, and the cure rate is 16 percent; the disease condition of patients with advanced lymphoma is relieved and controlled, the lymphodynia of the patients is relieved, and the growth of the lymphoma is delayed and controlled. The effective rate of the composition of the invention to 200 patients with lymphoma of deficiency fire phlegm accumulation syndrome is 75%.

Experimental example 4 concrete treatment cases of the pharmaceutical composition of the present invention for lymphatic system diseases

Case 1: plum, one certain, age 43, female. In 2008, the operation is performed on the cervical scrofula, 4 scrofula recurrences are found at the end of 2011, and two of the scrofula recurrences are large and can be painful when a user presses a walnut, and the user can also feel painful when pressing the walnut.

And (3) diagnosis results: the 4 th menstruation in 2013 is diagnosed as scrofula with the syndrome of deficiency fire and phlegm accumulation.

The treatment method comprises the following steps: after the diagnosis is confirmed, the patient takes the pharmaceutical composition prepared in example 1 of the present invention three times a day, and the dosage for one adult is 18-20 g once. The administration is continued for 4 months.

The treatment effect is as follows: after 4 months of treatment, the large scrofula of the walnuts is basically eliminated completely.

The photographs before and after the treatment of the patient are shown in fig. 1.

Case 2: somebody of business, age 31, male. Left cervical lymphoid tuberculosis was discovered in 2003 and accompanied by pulmonary tuberculosis, and then the pulmonary tuberculosis healed and the lymphoid tuberculosis was also hard mass after regularly taking antituberculosis drugs for eight months. In 2007, lymphoid tuberculosis recurs, the size of pigeon eggs is large, swelling and pain are caused, low fever is caused, and in 2007, acupuncture and cupping treatment is carried out in other hospitals. Recurrence of lymphoid tuberculosis appeared in 2013.

And (3) diagnosis results: in 2013, the diagnosis of 6-menstruation is scrofula with syndrome of deficiency fire and phlegm accumulation.

The treatment method comprises the following steps: after the diagnosis is confirmed, the patient takes the pharmaceutical composition prepared in example 1 of the present invention three times a day, and the dosage for one adult is 18-20 g once. The administration is continued for 3 months.

The treatment effect is as follows: after 3 months of administration, most lymphoid tuberculosis disappeared, leaving only one lymphoid tuberculosis, presumably half as large as peanuts.

The photographs of the patient before and after treatment are shown in figure 2.

Case 3: wang somebody, age 29, woman. In 2011 in summer, a patient finds that the neck is provided with a pimple, then goes to a hospital to be subjected to medical record examination and operation biopsy, but the wound is healed after half a year; the patient goes to a hospital for examination in 12 months in 2012, and lymphoid tuberculosis exists on the left and right sides of the neck; in 2013, after going to hospital for examination in 12 months, tuberculosis is found to be enlarged, the clavicle on the left side is also present, a small amount of new tuberculosis is also present, and in addition, the groin on the left side is found to have pimples with the size of soybeans without pain.

And (3) diagnosis results: the 1 st menstruation in 2014 is diagnosed as scrofula with the syndrome of deficiency fire and phlegm accumulation.

The treatment effect is as follows: after 3 months of administration, the skin has recovered to normal and lymphoid tuberculosis is completely eradicated.

The photographs of the patient before and after treatment are shown in figure 3.

Case 4: wu Yi in Wu, 38 years old, male. Lymphoid tuberculosis ulcerated for more than 50 days, but the wound did not heal. When the isoniazid tablet, the ethambutol hydrochloride tablet, the rifampicin capsule, the pyrazinamide tablet and the liver protection capsule are taken at first, after the drug is taken for 8 days after one month, the alanine in the millet is increased to more than 500, and after the drug liver function is normal for half a month, the pyrazinamide tablet, the isoniazid tablet, the ethambutol hydrochloride tablet, the rifampicin capsule, the liver protection capsule and the like are continuously used, but after the drug is taken for another month, a new lump with the size of 5 multiplied by 3CM is grown on the right side of the neck, and the neck is soft and suppurative at present. Old ulceration will not heal, new mass begins to suppurate, right side ulcerate later for one week, there is also a hole, new mass grows out after taking medicine for 2 months, 20 days later, soft and suppurative. Type B shows that there is more than 1CM lymph in the axilla and groin, but the morphology is good and cannot be seen by oneself.

And (3) diagnosis results: the 8 th menstruation in 2014 is diagnosed as scrofula with the syndrome of deficiency fire and phlegm accumulation.

The treatment method comprises the following steps: after the diagnosis is confirmed, the patient takes the pharmaceutical composition prepared in example 1 of the present invention three times a day, and the dosage for one adult is 18-20 g once. The administration is continued for 5 months.

The treatment effect is as follows: after 5 months of administration, substantially all wounds had healed and there was an ongoing effort to heal in the direction of normal skin.

The photographs before and after the treatment of the patient are shown in fig. 4.

Case 5: plum, a certain one, 26 years old, female. Two lymph nodes grow on the neck in 1 month in 2013, drainage is performed in 10 months in 2013, the wound grows on the upper side, but a small amount of residues in the wound are seen through CT, and one lymph node grows below the armpit in 6 months in 2014, is not broken, can be touched by hands, and is eaten all the time in anti-tuberculosis western medicines.

And (3) diagnosis results: the 12 th menstruation in 2014 is diagnosed as scrofula with the syndrome of deficiency fire and phlegm accumulation.

The treatment method comprises the following steps: after the diagnosis is confirmed, the patient takes the pharmaceutical composition prepared in example 1 of the present invention three times a day, and the dosage for one adult is 18-20 g once. The administration is continued for 1 month.

The treatment effect is as follows: after 1 month of administration, lymph nodes on neck of patients are improved obviously, neck has no stiffness, lymphoid tuberculosis is also eliminated, and focus is reduced.

The photographs before and after the treatment of the patient are shown in fig. 5.

Case 6: some in Rabbit, 31 years old, male. The patient has lymphoid tuberculosis for 3 months in one year, the hospital diagnosis is nontuberculous mycobacterium, western medicines for resisting tuberculosis are always adhered to, a method of taking medicine eggs is also used, the medicine has some effects, but the medicine cannot be completely cured, and the patient is accompanied with congenital immunologic dysfunction.

And (3) diagnosis results: scrofula with syndrome of accumulation of phlegm due to deficiency fire was diagnosed in 3 months in 2015.

The treatment method comprises the following steps: after the diagnosis is confirmed, the patient takes the pharmaceutical composition prepared in example 1 of the present invention three times a day, and the dosage for one adult is 18-20 g once. The administration is continued for 80 days.

The treatment effect is as follows: after 80 days of administration, lymphoid tuberculosis of the patients substantially disappeared.

The photographs before and after the treatment of the patient are shown in fig. 6.

Case 7: liu Yi in certain age, 62 years old, female. Mediastinal CT lymphadenectasis, lymphoma diagnosed by a plurality of hospitals, poor eating and sleeping, emaciation, continuous low fever and night sweat, hypodynamia of the body, chronic pharyngitis and heart disease, and chest pain.

And (3) diagnosis results: lymphoma with deficiency fire and phlegm accumulation was diagnosed on 6 menstruation in 2015.

The treatment effect is as follows: after 1 month of administration, the debilitation of the whole body is relieved, the persistent low fever and night sweat are avoided, and the chest and mouth are not painful; CT shows that there is no swelling of mediastinum and lymph nodes, and the symptoms are improved. After 3 months of administration, CT showed no lymphadenectasis, and hospital diagnosis showed that the disease had nearly healed. Fig. 7 is a CT examination report before patient administration, and fig. 8 is a CT examination report after patient administration.

In conclusion, the invention provides a traditional Chinese medicine composition prepared from muskroot-like semiaquilegia root, common selfheal fruit-spike, white rehmannia root, tuber fleeceflower root, honeysuckle flower, rabdosia rubescens, seaweed, tuber fleeceflower stem, fineleaf schizonepeta herb, honeysuckle stem and akebia stem. The Chinese medicinal composition has excellent treatment effect on lymphatic system diseases (including lymphadenitis, scrofula and lymphoma) with deficiency fire phlegm stagnation syndrome, and has high cure rate and small toxic and side effects. The pharmaceutical composition has wide application prospect in preparing the medicine for preventing and/or treating the lymphatic system diseases of the deficiency fire phlegm accumulation syndrome.

Claims

1. A traditional Chinese medicine composition is characterized in that: the preparation is prepared from the following raw material medicines in parts by weight: 280-320 parts of muskroot-like semiaquilegia root, 580-620 parts of selfheal, 430-470 parts of white cucumber, 230-270 parts of polygonum multiflorum, 180-220 parts of honeysuckle, 380-420 parts of lysimachia christinae hance, 80-120 parts of seaweed, 180-220 parts of tuber fleeceflower stem, 130-170 parts of schizonepeta, 180-220 parts of honeysuckle stem and 80-120 parts of akebia stem.

2. The traditional Chinese medicine composition according to claim 1, characterized in that: the preparation is prepared from the following raw material medicines in parts by weight: 300 parts of muskroot-like semiaquilegia root, 600 parts of selfheal, 450 parts of white ground cucumber, 250 parts of tuber fleeceflower root, 200 parts of honeysuckle flower, 400 parts of rabdosia rubescens, 100 parts of seaweed, 200 parts of tuber fleeceflower stem, 150 parts of fineleaf schizonepeta herb, 200 parts of honeysuckle stem and 100 parts of akebia stem.

3. The traditional Chinese medicine composition according to claim 1 or 2, wherein: the traditional Chinese medicine composition is a preparation prepared by taking the traditional Chinese medicine composition as an active ingredient according to any one of claims 1-2 and adding pharmaceutically acceptable auxiliary ingredients.

4. The traditional Chinese medicine composition according to claim 3, wherein: the formulation is an oral formulation.

5. The traditional Chinese medicine composition according to claim 4, wherein: the oral preparation is decoction, oral liquid, granule, capsule, powder, pill or tablet.

6. A method for preparing the Chinese medicinal composition of any one of claims 1 to 5, which is characterized by comprising the following steps: the method comprises the following steps:

(1) weighing the raw materials according to the weight ratio;

7. The method of claim 6, wherein: the method comprises the following steps:

8. The method of claim 7, wherein: in the step (i), the sieving is to pass through a sieve of 50-200 meshes, preferably a sieve of 100 meshes;

9. Use of the Chinese medicinal composition of any one of claims 1 to 5 in the preparation of a medicament for preventing and/or treating lymphatic system diseases caused by deficiency fire-phlegm stagnation.

10. Use according to claim 9, characterized in that: the lymphatic system diseases of deficiency fire phlegm accumulation syndrome are deficiency fire phlegm accumulation syndrome lymphadenitis, deficiency fire phlegm accumulation syndrome lymphadenitis or deficiency fire phlegm accumulation syndrome lymphoma.