CN112566645A - 用于原发性线粒体疾病的线粒体增强疗法 - Google Patents

用于原发性线粒体疾病的线粒体增强疗法 Download PDF

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Publication number
CN112566645A
CN112566645A CN201980053785.XA CN201980053785A CN112566645A CN 112566645 A CN112566645 A CN 112566645A CN 201980053785 A CN201980053785 A CN 201980053785A CN 112566645 A CN112566645 A CN 112566645A
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mitochondria
stem cells
mitochondrial
human
cells
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娜塔莉·伊夫吉奥哈纳
乌列·哈拉维
史密尔·布克施班
诺亚·谢尔
莫里亚·布鲁金
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Minovia Therapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors

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  • Cell Biology (AREA)
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  • Immunology (AREA)
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  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201980053785.XA 2018-07-22 2019-07-22 用于原发性线粒体疾病的线粒体增强疗法 Pending CN112566645A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862701783P 2018-07-22 2018-07-22
US62/701,783 2018-07-22
US201862753947P 2018-11-01 2018-11-01
US62/753,947 2018-11-01
PCT/IL2019/050823 WO2020021536A1 (en) 2018-07-22 2019-07-22 Mitochondrial augmentation therapy for primary mitochondrial diseases

Publications (1)

Publication Number Publication Date
CN112566645A true CN112566645A (zh) 2021-03-26

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CN201980053785.XA Pending CN112566645A (zh) 2018-07-22 2019-07-22 用于原发性线粒体疾病的线粒体增强疗法

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US (1) US12502408B2 (https=)
EP (1) EP3823647A4 (https=)
JP (2) JP7522095B2 (https=)
KR (1) KR20210035212A (https=)
CN (1) CN112566645A (https=)
AU (1) AU2019311859B2 (https=)
BR (1) BR112021001190A2 (https=)
CA (1) CA3106186A1 (https=)
IL (1) IL280163B2 (https=)
MX (1) MX2021000955A (https=)
WO (1) WO2020021536A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114699430A (zh) * 2022-04-12 2022-07-05 重庆理工大学 线粒体及其在胰腺炎中的应用和应用方法

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US12551504B2 (en) 2018-07-22 2026-02-17 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of pancreatic diseases
US12329781B2 (en) 2018-07-22 2025-06-17 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of renal diseases
JP2021531288A (ja) 2018-07-22 2021-11-18 ミノヴィア セラピューティクス リミテッド 眼疾患のミトコンドリア増強療法
WO2020021536A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy for primary mitochondrial diseases
JP7524157B2 (ja) 2018-07-22 2024-07-29 ミノヴィア セラピューティクス リミテッド 脳疾患のミトコンドリア増強療法
JP7458368B2 (ja) 2018-07-22 2024-03-29 ミノヴィア セラピューティクス リミテッド 筋疾患のミトコンドリア増強療法
CA3172402A1 (en) 2020-03-31 2021-10-07 Minovia Therapeutics Ltd. Mitochondria-enriched genetically engineered cells and uses thereof
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WO2021224920A1 (en) * 2020-05-05 2021-11-11 Pluristem Ltd. Methods and compositions for enrichment of target cells
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JP7522095B2 (ja) 2024-07-24
EP3823647A1 (en) 2021-05-26
IL280163B1 (en) 2025-09-01
CA3106186A1 (en) 2020-01-30
IL280163B2 (en) 2026-01-01
EP3823647A4 (en) 2022-06-01
KR20210035212A (ko) 2021-03-31
IL280163A (en) 2021-03-01
WO2020021536A9 (en) 2020-03-05
US12502408B2 (en) 2025-12-23
JP2021531284A (ja) 2021-11-18
JP2024138460A (ja) 2024-10-08
MX2021000955A (es) 2021-05-27
WO2020021536A1 (en) 2020-01-30
AU2019311859B2 (en) 2025-12-18
AU2019311859A1 (en) 2021-02-04
BR112021001190A2 (pt) 2021-04-27
US20210260137A1 (en) 2021-08-26

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