BR112021001190A2 - terapia de reforço mitocondrial para doenças mitocondriais primárias - Google Patents

terapia de reforço mitocondrial para doenças mitocondriais primárias Download PDF

Info

Publication number
BR112021001190A2
BR112021001190A2 BR112021001190-0A BR112021001190A BR112021001190A2 BR 112021001190 A2 BR112021001190 A2 BR 112021001190A2 BR 112021001190 A BR112021001190 A BR 112021001190A BR 112021001190 A2 BR112021001190 A2 BR 112021001190A2
Authority
BR
Brazil
Prior art keywords
stem cells
mitochondria
mitochondrial
human
cells
Prior art date
Application number
BR112021001190-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Natalie Yivgi Ohana
Uriel Halavee
Shmuel Bukshpan
Noa Sher
Moriya Blumkin
Original Assignee
Minovia Therapeutics Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minovia Therapeutics Ltd. filed Critical Minovia Therapeutics Ltd.
Publication of BR112021001190A2 publication Critical patent/BR112021001190A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112021001190-0A 2018-07-22 2019-07-22 terapia de reforço mitocondrial para doenças mitocondriais primárias BR112021001190A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862701783P 2018-07-22 2018-07-22
US62/701,783 2018-07-22
US201862753947P 2018-11-01 2018-11-01
US62/753,947 2018-11-01
PCT/IL2019/050823 WO2020021536A1 (en) 2018-07-22 2019-07-22 Mitochondrial augmentation therapy for primary mitochondrial diseases

Publications (1)

Publication Number Publication Date
BR112021001190A2 true BR112021001190A2 (pt) 2021-04-27

Family

ID=69181378

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021001190-0A BR112021001190A2 (pt) 2018-07-22 2019-07-22 terapia de reforço mitocondrial para doenças mitocondriais primárias

Country Status (11)

Country Link
US (1) US12502408B2 (https=)
EP (1) EP3823647A4 (https=)
JP (2) JP7522095B2 (https=)
KR (1) KR20210035212A (https=)
CN (1) CN112566645A (https=)
AU (1) AU2019311859B2 (https=)
BR (1) BR112021001190A2 (https=)
CA (1) CA3106186A1 (https=)
IL (1) IL280163B2 (https=)
MX (1) MX2021000955A (https=)
WO (1) WO2020021536A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL282198B2 (en) 2011-09-11 2025-11-01 Minovia Therapeutics Ltd Compositions of functional mitochondria and uses thereof
WO2020021535A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of ocular diseases
US11951135B2 (en) 2018-07-22 2024-04-09 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of muscle diseases
EP3823646A4 (en) 2018-07-22 2022-06-08 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of brain diseases
AU2019311859B2 (en) 2018-07-22 2025-12-18 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy for primary mitochondrial diseases
JP7586811B2 (ja) * 2018-07-22 2024-11-19 ミノヴィア セラピューティクス リミテッド 腎臓疾患のミトコンドリア増強療法
EP3823644A4 (en) 2018-07-22 2022-06-08 Minovia Therapeutics Ltd. MITOCHONDRIAL AUGMENTATION THERAPY OF PANCREATIC DISEASES
BR112022019609A2 (pt) 2020-03-31 2022-11-29 Minovia Therapeutics Ltd Células geneticamente modificadas enriquecidas com mitocôndrias e usos das mesmas
AU2021248780A1 (en) * 2020-03-31 2022-11-10 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy
WO2021224920A1 (en) * 2020-05-05 2021-11-11 Pluristem Ltd. Methods and compositions for enrichment of target cells
CN114699430A (zh) * 2022-04-12 2022-07-05 重庆理工大学 线粒体及其在胰腺炎中的应用和应用方法
US20260069634A1 (en) * 2022-04-27 2026-03-12 Paean Biotechnology Inc. Pharmaceutical composition, for preventing or treating hearing loss or tinnitus, comprising mitochondria as active ingredient
KR20250065545A (ko) * 2023-11-03 2025-05-13 서울대학교병원 미토콘드리아를 유효성분으로 포함하는 유전성 난청의 예방 또는 치료용 약학 조성물

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2186636A1 (en) 1994-03-30 1995-10-12 Corinna Herrnstadt Diagnosis, therapy and cellular and animal models for diseases associated with mitochondrial defects
US6472378B2 (en) 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
EP1119368A2 (en) 1999-03-03 2001-08-01 Biogen, Inc. Methods of modulating lipid metabolism and storage
GB2350565A (en) 1999-05-28 2000-12-06 Johnson & Johnson Medical Ltd Biological wound dressings comprising mitochondria
DE19937348A1 (de) 1999-08-11 2001-02-22 Aventis Cropscience Gmbh Nukleinsäuremoleküle aus Pflanzen codierend Enzyme, die an der Stärkesynthese beteiligt sind
EP1267800A4 (en) 2000-03-31 2004-08-25 Gen Hospital Corp METHOD FOR INFLUENCING HAIR GROWTH
WO2002030418A1 (fr) 2000-10-13 2002-04-18 Chugai Seiyaku Kabushiki Kaisha Compositions servant a ameliorer le metabolisme lipidique
US20030040475A1 (en) 2001-01-16 2003-02-27 Yasuhiro Toba Agents for improving lipid metabolism and reducing high blood pressure
US7339090B2 (en) 2001-02-13 2008-03-04 Avigenics, Inc. Microinjection devices and methods of use
JP4603192B2 (ja) 2001-05-10 2010-12-22 株式会社カネカ 毛髪頭皮用組成物
AU2002330938A1 (en) 2001-07-31 2003-02-17 Northeastern University Mitochondrial genome replenishment
EP1423504B1 (en) 2001-08-08 2009-09-23 Levesque Biosciences, Inc. Compositions and methods for isolation, propagation, and differentiation of non-embryonic human stem cells and uses thereof
US7138134B2 (en) 2001-12-18 2006-11-21 Arizona Health Consulting Group, Llc Preparation and administration of jojoba product for reducing weight, fat and blood lipid levels
US20050153381A1 (en) 2002-02-14 2005-07-14 Marusich Michael F. Immunocapture of mitochondrial protein complexes
CA2525560A1 (en) 2003-05-13 2004-11-25 The Regents Of The University Of Colorado Diagnostic and therapeutic treatments related to mitochondrial disorders
EP1626732B1 (en) 2003-05-22 2013-04-03 CHIESI FARMACEUTICI S.p.A. Means for preventing and treating cellular death and their biological applications
US7407800B1 (en) 2003-09-19 2008-08-05 Pierce Biotechnology, Inc. Method for the isolation of intact mitochondria from cells
EP1709084A4 (en) 2003-12-23 2008-05-28 Nono Inc POLYPEPTIDES FOR MODULATING BINDING OF TRP-CHANNEL PROTEINS AND TRP-ASSOCIATED PROTEINS
US20060024277A1 (en) 2004-07-27 2006-02-02 Sivak Hannah N Method of skin care and/or treatment using extracts enriched in mitochondria
JP2006131600A (ja) 2004-11-09 2006-05-25 R & D Cell-Science Optional Medico:Kk 発毛促進のためのヒト細胞組成物
ES2619303T3 (es) 2005-06-01 2017-06-26 Edison Pharmaceuticals, Inc. Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos
CA2609208C (en) 2005-06-10 2016-10-18 Per-Ake Albertsson Use of plant cell membrane for the treatment of obesity
AU2012201710B2 (en) 2006-05-11 2014-01-16 Regenics As Administration of cells and cellular extracts for rejuvenation
AT502353B1 (de) 2006-06-29 2007-07-15 Avl List Gmbh Verfahren und vorrichtung zur konditionierung eines o2-hältigen gases
US9603872B2 (en) 2007-05-02 2017-03-28 The McLeon Hospital Corporation Methods and compositions for mitochondrial replacement therapy
WO2008152640A2 (en) 2007-06-13 2008-12-18 Pluristem Ltd. Three dimensional biocompatible scaffolds for ex-vivo expansion and transplantation of stem cells
JP5866601B2 (ja) 2008-06-18 2016-02-17 ザ テキサス エーアンドエム ユニバーシティ システムＴｈｅ Ｔｅｘａｓ Ａ＆Ｍ Ｕｎｉｖｅｒｓｉｔｙ Ｓｙｓｔｅｍ 医薬組成物の製造方法
WO2011059547A2 (en) 2009-10-30 2011-05-19 Xenotech, Llc Cryopreservation of cells and subcellular fractions
US8846028B2 (en) 2010-10-28 2014-09-30 The Invention Science Fund I, Llc Mitochondrial enhancement of cells
US8883838B2 (en) 2010-12-03 2014-11-11 Allergan, Inc. Pharmaceutical cream compositions and methods of use
PH12022550598A1 (en) 2010-12-23 2024-03-11 Amazentis Sa Compositions and methods for improving mitochondrial function and treating neurodenegenerative diseases and cognitive disorders
EA201490050A1 (ru) 2011-06-29 2014-07-30 Зе Дженерэл Хоспитэл Корпорейшн Композиции и способы повышения биоэнергетического состояния женских зародышевых клеток
CN102266350A (zh) 2011-07-20 2011-12-07 黄必录 逆转干细胞衰老的方案
US20130022666A1 (en) 2011-07-20 2013-01-24 Anna Brzezinska Methods and compositions for transfer of mitochondria into mammalian cells
CN102293178A (zh) 2011-08-28 2011-12-28 黄必录 使个体去衰老的方法
IL282198B2 (en) 2011-09-11 2025-11-01 Minovia Therapeutics Ltd Compositions of functional mitochondria and uses thereof
JP6220791B2 (ja) 2011-12-02 2017-10-25 フェイト セラピューティクス，インコーポレイテッド 増強された幹細胞組成物
US8648034B2 (en) 2011-12-09 2014-02-11 Changhua Christian Hospital Method and applications of peptide-mediated mitochondrial delivery system
WO2013149064A1 (en) 2012-03-30 2013-10-03 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Uridine diphosphate compounds as mobilizers of hematopoietic progenitor cells
WO2013171752A1 (en) 2012-05-16 2013-11-21 Minovia Therapeutics Ltd. Compositions and methods for inducing angiogenesis
EP3459522B1 (en) 2012-12-10 2021-02-17 Regenics AS Use of egg cellular extracts for wound treatment
AU2014219026B2 (en) 2013-02-19 2018-11-29 Children's Medical Center Corporation ABCB5(+) stem cells for treating ocular disease
DE102013225588A1 (de) 2013-12-11 2014-04-17 Henkel Ag & Co. Kgaa Verwendung und Mittel zur Verbesserung der Haarstruktur
AU2015214145A1 (en) 2014-02-04 2016-08-25 Kite Pharma. Inc. Methods for producing autologous T cells useful to treat B cell malignancies and other cancers and compositions thereof
EP2918458B1 (en) 2014-03-11 2016-12-07 Autoliv Development AB A vehicle braking arrangement
WO2015142855A1 (en) 2014-03-17 2015-09-24 University Of Virginia Patent Foundation Compositions and methods for treating retinopathy
CN103976935A (zh) 2014-05-28 2014-08-13 广州市白云区天芳化妆品厂 一种抗衰原液及其制备方法
KR20170032406A (ko) 2014-07-15 2017-03-22 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 치료를 위한 조작된 세포
WO2016008937A1 (en) * 2014-07-16 2016-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the intercellular transfer of isolated mitochondria in recipient cells
TWI707040B (zh) 2014-09-11 2020-10-11 台灣粒線體應用技術股份有限公司 一種用於治療退化性神經疾病的細胞、含有該細胞的醫藥組合物及其應用
JP6441472B2 (ja) 2014-09-30 2018-12-19 台灣粒線體應用技術股▲扮▼有限公司Ｔａｉｗａｎ Ｍｉｔｏｃｈｏｎｄｒｉｏｎ Ａｐｐｌｉｅｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．，Ｌｔｄ． 活性成分として外因性ミトコンドリアを含む組成物、ならびにその使用およびそのための細胞修復法
JP6644702B2 (ja) 2014-11-14 2020-02-12 Ｊｃｒファーマ株式会社 歯髄由来多能性幹細胞を含有する筋ジストロフィー治療剤
GB201500427D0 (en) 2015-01-12 2015-02-25 Isis Innovation Method
US20180007913A1 (en) 2015-01-14 2018-01-11 Calix Ltd Improved pathogen inhibitor
WO2016115632A1 (en) * 2015-01-21 2016-07-28 Exerkine Corporation Method for treating mitochondrial disease
US10472340B2 (en) 2015-02-17 2019-11-12 Arizona Board Of Regents On Behalf Of Arizona State University Substituted phenothiazines as mitochondrial agents
IL299482B2 (en) 2015-02-26 2025-02-01 Minovia Therapeutics Ltd Mammalian cells are enriched with active mitochondria
MA41757A (fr) 2015-02-27 2018-01-03 Univ Connecticut Transplantation ciblée de mitochondries dans des hépatocytes
EP3302065A4 (en) * 2015-05-28 2019-04-10 Celularity, Inc. PLACENTIAL STEM CELLS FOR RECOVERING THE REGENERATIVE MOTOR, CORRECTING PROTEOMIC DEFECTS AND EXTENDING THE LIFE
US11903974B2 (en) 2015-11-30 2024-02-20 Flagship Pioneering Innovations V, Inc. Methods and compositions relating to chondrisomes from cultured cells
JP2017105729A (ja) 2015-12-10 2017-06-15 国立大学法人東北大学 ミトコンドリア病の治療剤
WO2017124037A1 (en) 2016-01-15 2017-07-20 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents
KR20190109389A (ko) 2016-11-03 2019-09-25 엑소스템 바이오텍 리미티드 간엽 줄기 세포 집단, 이들의 산물 및 이들의 용도
JP7187036B2 (ja) 2016-11-14 2022-12-12 パイアン バイオテクノロジ－ インコーポレイテッド 外因性ミトコンドリアを細胞内に送達する方法
JP2020502078A (ja) 2016-11-30 2020-01-23 パイアン・バイオテクノロジー・インコーポレイテッドＰａｅａｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｉｎｃ． ミトコンドリアを含む医薬組成物
WO2018178970A1 (en) 2017-03-26 2018-10-04 Minovia Therapeutics Ltd. Mitochondrial compositions and methods for treatment of skin and hair
WO2020021535A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of ocular diseases
EP3823644A4 (en) 2018-07-22 2022-06-08 Minovia Therapeutics Ltd. MITOCHONDRIAL AUGMENTATION THERAPY OF PANCREATIC DISEASES
EP3823643A4 (en) 2018-07-22 2022-06-08 Minovia Therapeutics Ltd. MITOCHONDRIAL AUGMENTATION THERAPY OF LIVER DISEASES
EP3823646A4 (en) 2018-07-22 2022-06-08 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of brain diseases
AU2019311859B2 (en) 2018-07-22 2025-12-18 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy for primary mitochondrial diseases
US11951135B2 (en) 2018-07-22 2024-04-09 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of muscle diseases
US20210322485A1 (en) 2018-07-22 2021-10-21 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy with stem cells enriched with functional mitochondria
US20200054682A1 (en) 2018-08-14 2020-02-20 Imel Biotherapeutics, Inc. Methods and compositions for treating mitochondrial disease or disorders and heteroplasmy
CN121610569A (zh) 2019-04-30 2026-03-06 拉利玛生物医药公司 用于测定共济蛋白替代疗法的疗效的共济蛋白敏感性标志物
BR112022019609A2 (pt) 2020-03-31 2022-11-29 Minovia Therapeutics Ltd Células geneticamente modificadas enriquecidas com mitocôndrias e usos das mesmas
AU2021248780A1 (en) 2020-03-31 2022-11-10 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy

Also Published As

Publication number Publication date
WO2020021536A9 (en) 2020-03-05
CN112566645A (zh) 2021-03-26
JP2024138460A (ja) 2024-10-08
JP2021531284A (ja) 2021-11-18
JP7522095B2 (ja) 2024-07-24
US20210260137A1 (en) 2021-08-26
IL280163B1 (en) 2025-09-01
IL280163B2 (en) 2026-01-01
IL280163A (en) 2021-03-01
AU2019311859A1 (en) 2021-02-04
EP3823647A1 (en) 2021-05-26
US12502408B2 (en) 2025-12-23
WO2020021536A1 (en) 2020-01-30
MX2021000955A (es) 2021-05-27
EP3823647A4 (en) 2022-06-01
CA3106186A1 (en) 2020-01-30
AU2019311859B2 (en) 2025-12-18
KR20210035212A (ko) 2021-03-31

Similar Documents

Publication Publication Date Title
US12502408B2 (en) Mitochondrial augmentation therapy for primary mitochondrial diseases
US20240415894A1 (en) Mitochondrial augmentation therapy with stem cells enriched with functional mitochondria
US12239672B2 (en) Mitochondrial augmentation therapy of ocular diseases
US12551504B2 (en) Mitochondrial augmentation therapy of pancreatic diseases
US11951135B2 (en) Mitochondrial augmentation therapy of muscle diseases
US12440515B2 (en) Mitochondrial augmentation therapy of brain diseases
JP2021532095A (ja) 肝臓疾患のミトコンドリア増強療法

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2841 DE 17-06-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.