MA41757A - Transplantation ciblée de mitochondries dans des hépatocytes - Google Patents
Transplantation ciblée de mitochondries dans des hépatocytesInfo
- Publication number
- MA41757A MA41757A MA041757A MA41757A MA41757A MA 41757 A MA41757 A MA 41757A MA 041757 A MA041757 A MA 041757A MA 41757 A MA41757 A MA 41757A MA 41757 A MA41757 A MA 41757A
- Authority
- MA
- Morocco
- Prior art keywords
- mitochondria
- hepatocytes
- transplantation
- targeted
- targeted transplantation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A61K47/6455—Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Marine Sciences & Fisheries (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne, entre autres, des compositions et des trousses comprenant une asialoglycoprotéine liée de manière covalente à un polycation, et des mitochondries fonctionnelles de mammifère qui tirent au moins partiellement purifiées et sont électrostatiquement liées à la molécule de poly-asg; ainsi que des méthodes de préparation et d'utilisation.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562126068P | 2015-02-27 | 2015-02-27 | |
US15/553,717 US10537594B2 (en) | 2015-02-27 | 2016-02-26 | Targeted transplantation of mitochondria to hepatocytes |
PCT/US2016/019845 WO2016138420A1 (fr) | 2015-02-27 | 2016-02-26 | Transplantation ciblée de mitochondries dans des hépatocytes |
Publications (1)
Publication Number | Publication Date |
---|---|
MA41757A true MA41757A (fr) | 2018-01-03 |
Family
ID=55587354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA041757A MA41757A (fr) | 2015-02-27 | 2016-02-26 | Transplantation ciblée de mitochondries dans des hépatocytes |
Country Status (5)
Country | Link |
---|---|
US (1) | US10537594B2 (fr) |
EP (1) | EP3261677B1 (fr) |
JP (1) | JP2018507865A (fr) |
MA (1) | MA41757A (fr) |
WO (1) | WO2016138420A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2741757B1 (fr) | 2011-09-11 | 2018-05-16 | Minovia Therapeutics Ltd. | Compositions de mitochondries fonctionnelles et leurs utilisations |
WO2019028469A1 (fr) * | 2017-08-04 | 2019-02-07 | The Methodist Hospital | Compositions mitochondriales a polymère fonctionnalisé et procédés d'utilisation dans une transplantation cellulaire et pour modifier un phénotype métabolique |
EP3823640A4 (fr) | 2018-07-22 | 2022-05-18 | Minovia Therapeutics Ltd. | Thérapie d'augmentation mitochondriale de maladies musculaires |
WO2020021537A1 (fr) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Thérapie d'augmentation mitochondriale de maladies hépatiques |
US20220145330A1 (en) * | 2019-02-10 | 2022-05-12 | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads | Modified mitochondrion and methods of use thereof |
TWI780431B (zh) * | 2020-05-08 | 2022-10-11 | 台灣粒線體應用技術股份有限公司 | 新穎性醫藥組合物及其於修復肝臟損傷、治療肝臟損傷相關疾病與提升肝臟功能之用途 |
WO2024076572A1 (fr) * | 2022-10-06 | 2024-04-11 | Mitrix Bio Inc. | Formulations et procédés pour thérapies cellulaires impliquant des récepteurs antigéniques chimériques |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
US5728399A (en) | 1994-06-29 | 1998-03-17 | University Of Conn. | Use of a bacterial component to enhance targeted delivery of polynucleotides to cells |
TWI404801B (zh) * | 2011-06-15 | 2013-08-11 | 胜肽粒線體移植系統方法及其用途 | |
EP2741757B1 (fr) | 2011-09-11 | 2018-05-16 | Minovia Therapeutics Ltd. | Compositions de mitochondries fonctionnelles et leurs utilisations |
US8648034B2 (en) * | 2011-12-09 | 2014-02-11 | Changhua Christian Hospital | Method and applications of peptide-mediated mitochondrial delivery system |
-
2016
- 2016-02-26 JP JP2017544947A patent/JP2018507865A/ja active Pending
- 2016-02-26 MA MA041757A patent/MA41757A/fr unknown
- 2016-02-26 EP EP16711064.2A patent/EP3261677B1/fr active Active
- 2016-02-26 US US15/553,717 patent/US10537594B2/en active Active
- 2016-02-26 WO PCT/US2016/019845 patent/WO2016138420A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2016138420A1 (fr) | 2016-09-01 |
US20180036344A1 (en) | 2018-02-08 |
EP3261677A1 (fr) | 2018-01-03 |
US10537594B2 (en) | 2020-01-21 |
EP3261677B1 (fr) | 2019-04-10 |
JP2018507865A (ja) | 2018-03-22 |
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