CN112552236B - 一种博舒替尼1,3-丙二醚类二聚体杂质及其制备方法 - Google Patents

一种博舒替尼1,3-丙二醚类二聚体杂质及其制备方法 Download PDF

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Publication number
CN112552236B
CN112552236B CN202011484510.2A CN202011484510A CN112552236B CN 112552236 B CN112552236 B CN 112552236B CN 202011484510 A CN202011484510 A CN 202011484510A CN 112552236 B CN112552236 B CN 112552236B
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formula
reaction
bosutinib
follows
prepared
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Chinese (zh)
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CN112552236A (zh
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姚继明
许毅
王蓉蓉
黄辉
刘宏
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Nanjing Huawe Medicine Technology Group Co Ltd
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Nanjing Huawe Medicine Technology Group Co Ltd
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Priority to CN202011484510.2A priority Critical patent/CN112552236B/zh
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Priority to PCT/CN2021/123807 priority patent/WO2022127327A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202011484510.2A 2020-12-16 2020-12-16 一种博舒替尼1,3-丙二醚类二聚体杂质及其制备方法 Active CN112552236B (zh)

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Application Number Priority Date Filing Date Title
CN202011484510.2A CN112552236B (zh) 2020-12-16 2020-12-16 一种博舒替尼1,3-丙二醚类二聚体杂质及其制备方法
PCT/CN2021/123807 WO2022127327A1 (fr) 2020-12-16 2021-10-14 Impureté dimère de 1,3-propanediéther de bosutinib et son procédé de préparation

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CN202011484510.2A CN112552236B (zh) 2020-12-16 2020-12-16 一种博舒替尼1,3-丙二醚类二聚体杂质及其制备方法

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CN112552236A CN112552236A (zh) 2021-03-26
CN112552236B true CN112552236B (zh) 2022-02-22

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WO (1) WO2022127327A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112552236B (zh) * 2020-12-16 2022-02-22 南京华威医药科技集团有限公司 一种博舒替尼1,3-丙二醚类二聚体杂质及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105085398A (zh) * 2015-09-06 2015-11-25 合肥华方医药科技有限公司 一种博舒替尼异构体杂质的制备方法
CN110372539A (zh) * 2019-07-15 2019-10-25 杭州中美华东制药有限公司 一种伯舒替尼化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019186429A1 (fr) * 2018-03-30 2019-10-03 Sun Pharmaceutical Industries Limited Procédé de préparation de bosutinib
CN112552236B (zh) * 2020-12-16 2022-02-22 南京华威医药科技集团有限公司 一种博舒替尼1,3-丙二醚类二聚体杂质及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105085398A (zh) * 2015-09-06 2015-11-25 合肥华方医药科技有限公司 一种博舒替尼异构体杂质的制备方法
CN110372539A (zh) * 2019-07-15 2019-10-25 杭州中美华东制药有限公司 一种伯舒替尼化合物及其制备方法

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WO2022127327A1 (fr) 2022-06-23
CN112552236A (zh) 2021-03-26

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