CN112544987A - Composition for improving sperm activity and preparation method and application thereof - Google Patents
Composition for improving sperm activity and preparation method and application thereof Download PDFInfo
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- CN112544987A CN112544987A CN202011407281.4A CN202011407281A CN112544987A CN 112544987 A CN112544987 A CN 112544987A CN 202011407281 A CN202011407281 A CN 202011407281A CN 112544987 A CN112544987 A CN 112544987A
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- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims description 7
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 6
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- 102000009151 Luteinizing Hormone Human genes 0.000 description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A23L33/165—Complexes or chelates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a composition for improving sperm activity, and relates to the technical field of functional foods. Comprises linseed oil powder, rice bran fatty alkanol, ossein protein peptide, stachyose, rhizoma polygonati, taurine, cordyceps militaris powder, L-carnitine, mulberry powder, ginseng powder, vitamin E, wolfberry powder, eucommia male pollen, peptide powder, trace elements and auxiliary materials. The invention uses linseed oil powder, rice bran fatty alkanol, ossein peptide, stachyose and other raw materials to achieve the purposes of improving kidney function and improving sperm motility by supplementing nutrient components and trace elements to human body; the composition can effectively improve the quality and the activity of germ cells, reduce oxidative stress injury of the germ cells and simultaneously enhance the combining capacity of sperms and ova, and has the advantages of quick response, safety, reliability and no toxic or side effect; the preparation method is simple and feasible, and has wide application prospect.
Description
Technical Field
The invention relates to the technical field of functional foods, in particular to a composition for improving sperm activity and a preparation method and application thereof.
Background
Reproductive function can be assessed in a variety of ways, for example, from the structural integrity of testicular tissue, abnormalities in sperm morphology, high or low testosterone levels in the blood, or oxidative stress on sperm.
At present, due to the aggravation of social competition, men are under greater working pressure, and in addition, the aggravation of environmental pollution, more chemical substances which influence the generation and maturation of sperms are absorbed by the men through various ways, so that the quantity of the sperms generated by the men is reduced, and the activity of the sperms is reduced; according to statistics, male infertility accounts for 35% -50% of all infertility, and oligospermia is an important factor causing male infertility. Sperm density in semen is less than 20 x 106The number per ml is oligospermia; asthenospermia is detected when less than 50% of the sperm of grade a + b or less than 25% of the sperm of grade a are present in the semen. Modern medicine believes that genetics, endocrine, varicocele, infection, radiation and the like all can affect spermatogenesis and maturation, resulting in infertility. The oligospermia and asthenospermia gradually become global difficult miscellaneous diseases, and seriously affect the physical and mental health and family harmony of male patients.
Therefore, it is a technical problem to be solved by those skilled in the art to provide a composition capable of improving sperm activity with fast effect, safety, reliability, and no toxic side effect.
Disclosure of Invention
In view of the above, the invention provides a composition for improving sperm activity, a preparation method and an application thereof, and the composition has the advantages of quick response, safety, reliability and no toxic or side effect.
In order to achieve the purpose, the invention adopts the following technical scheme:
a composition for improving sperm activity comprises the following raw materials in parts by weight: 5-15 parts of linseed oil powder, 1-3 parts of rice bran fatty alkanol, 2-6 parts of collagen peptide, 1-3 parts of stachyose, 0.5-2 parts of rhizoma polygonati, 1-3 parts of taurine, 4-8 parts of cordyceps militaris powder, 1-5 parts of L-carnitine, 10-25 parts of mulberry powder, 0.2-1.5 parts of ginseng powder, 0.2-1.5 parts of raspberry powder, 0.5-1 part of wolfberry powder, 0.3-1.2 parts of eucommia male pollen, 5-10 parts of peptide powder, 10-15 parts of trace elements and 15-25 parts of auxiliary materials.
Further, the peptide powder is oyster peptide powder or sea cucumber peptide powder; the ginseng powder is artificially planted ginseng powder.
The beneficial effect of adopting the further scheme is that: the oyster is rich in natural protein zinc, selenium and iron, has vital effects on the generation of semen, the quality of sperms and the secretion of sex hormones, is rich in oyster polysaccharide and arginine, is the best energy source for supplementing energy and physical strength, and is also a raw material for generating endogenous erectile promoting substances; the sea cucumber is warm in nature, salty in taste, capable of entering heart and kidney channels, tonifying kidney essence, controlling urination, tonifying yang and treating flaccidity; can be used for treating sexual impotence, premature ejaculation, spermatorrhea, nocturia, frequent micturition, soreness of waist and knees.
Further, the trace elements include zinc chelate, manganese chelate, copper chelate and iron chelate.
Furthermore, the mass ratio of the chelated zinc to the chelated manganese to the chelated copper to the chelated iron is 1:0.3-0.6:0.2-0.4: 0.5-0.8.
The beneficial effect of adopting the further scheme is that: the trace elements such as zinc and the like are necessary trace elements for the formation of sperms, the trace elements are related to the quality of seminal fluid, and the concentration of the trace elements in seminal plasma obviously influences the density and the vitality of the sperms; the trace elements are added to the invention to assist other substances in the invention to improve the sperm motility.
Furthermore, the auxiliary material is isomaltooligosaccharide and/or fructo-oligosaccharide.
Furthermore, the composition for improving sperm activity also comprises 1-5 parts of morchella extract.
The beneficial effect of adopting the further scheme is that: the isomaltooligosaccharide and/or fructo-oligosaccharide is/are used as main auxiliary materials, can act on the regulation effect of micro-ecology, play the effect of prebiotics, add beneficial flora, obviously inhibit harmful bacteria, improve the functions of spleen and stomach, improve the renal function from physique and further improve the sperm motility.
The invention also provides a preparation method of the composition for improving sperm activity, which comprises the following steps:
(1) weighing the raw materials in parts by weight;
(2) mixing and dispersing linseed oil powder, rice bran fatty alkanol, ossein peptide, stachyose, cordyceps militaris powder, L-carnitine and mulberry powder in water, and standing at normal temperature for 12-18h for later use;
(3) pulverizing rhizoma Polygonati, mixing with Ginseng radix powder, Rubi fructus powder, fructus Lycii powder, Eucommiae cortex male pollen, peptide powder and microelements, dispersing in organic solvent, heating the organic solvent at 50-80 deg.C for 10-15 hr, adding the water dispersion in step (2) into the organic solvent, stirring, and mixing to obtain mixed solution;
(4) adding auxiliary materials into the mixed solution, then centrifuging and filtering to remove residues;
(5) adjusting pH of the mixed solution to 5.5-7, freeze drying the mixed solution, and sterilizing the lyophilized powder to obtain the composition for improving sperm activity.
Further, the preparation method of the morchella extract comprises the following steps:
pulverizing Morchella esculenta, sieving with a 120-mesh sieve, adding Morchella esculenta powder into 55% ethanol solution, and reflux-extracting at 85 deg.C for 10 hr to obtain Morchella esculenta extract;
the morchella extract is dispersed in an organic solvent in the step (3).
The beneficial effect of adopting the further scheme is that: the ethanol extraction is adopted to reflux and extract the morchella, so that the effective substances in the morchella are fully dissolved, and the effective components in the morchella are more favorably absorbed after being taken.
Further, the organic solvent in the step (3) is ethanol with the concentration of 60-85%;
the stirring speed is 100-150r/min, and the stirring time is 10-20 min;
the centrifugation speed in the step (4) is 3000-.
The beneficial effect of adopting the further scheme is that: the raw materials are fully and uniformly mixed, and the synergistic effect among the raw materials is improved.
Further, in the step (5), the freeze-drying temperature is-30 to-20 ℃, and the freeze-drying time is 12-18 h;
the sterilization method comprises sterilizing with 365nm ultraviolet rays at 110 deg.C for 5-10 min.
The beneficial effect of adopting the further scheme is that: the product of the invention is prepared into freeze-dried powder, which is more convenient to carry and absorb after being taken.
The invention has the beneficial effects that: the purposes of improving renal function and improving sperm motility are achieved by supplementing nutrient components and trace elements to a human body by using linseed oil powder, rice bran fatty alkanol, ossein peptide, stachyose and other raw materials; the composition can effectively improve the quality and the activity of germ cells, reduce oxidative stress injury of the germ cells and simultaneously enhance the combining capacity of sperms and ova, and has the advantages of quick response, safety, reliability and no toxic or side effect; the preparation method is simple and feasible, and has wide application prospect.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The ginseng powder adopted in the embodiment of the invention is artificially planted ginseng powder.
Example 1
A composition for enhancing sperm motility:
(1) weighing 15g of linseed oil powder, 1g of rice bran fatty alkanol, 6g of collagen peptide, 1g of stachyose, 2g of rhizoma polygonati, 3g of taurine, 8g of cordyceps militaris powder, 1g of L-carnitine, 10g of mulberry powder, 0.2g of ginseng powder, 1.5g of raspberry powder, 1g of wolfberry powder, 0.3g of eucommia male pollen, 5g of oyster peptide powder, 15g of trace elements, 10g of isomaltooligosaccharide and 15g of fructo-oligosaccharide;
the trace elements comprise chelated zinc, chelated manganese, chelated copper and chelated iron, and the mass ratio of the chelated zinc to the chelated manganese to the chelated copper to the chelated iron is 1:0.3:0.4: 0.8;
(2) mixing and dispersing linseed oil powder, rice bran fatty alkanol, ossein peptide, stachyose, cordyceps militaris powder, L-carnitine and mulberry powder in water, and standing at normal temperature for 18 hours for later use;
(3) pulverizing rhizoma Polygonati, mixing with Ginseng radix powder, Rubi fructus powder, fructus Lycii powder, Eucommiae cortex male pollen, peptide powder and microelements, dispersing in 60% ethanol, heating ethanol at 50 deg.C for 15h, adding the water dispersion in step (2) into ethanol at 150r/min, and stirring for 10min to obtain mixed solution;
(4) adding adjuvants into the mixed solution, centrifuging at 5000r/min for 5min, and filtering to remove residue;
(5) adjusting pH of the mixed solution to 7, freeze drying the mixed solution at-30 deg.C for 12h, and sterilizing the lyophilized powder at 110 deg.C with 365nm ultraviolet ray for 5min to obtain the composition for improving sperm activity.
Example 2
A composition for enhancing sperm motility:
(1) pulverizing Morchella esculenta, sieving with a 120-mesh sieve, adding Morchella esculenta powder into 55% ethanol solution, and reflux-extracting at 85 deg.C for 10 hr to obtain Morchella esculenta extract;
weighing 5g of linseed oil powder, 3g of rice bran fatty alkanol, 2g of collagen peptide, 3g of stachyose, 0.5g of rhizoma polygonati, 1g of taurine, 4g of cordyceps militaris powder, 5g of L-carnitine, 25g of mulberry powder, 1.5g of ginseng powder, 0.2g of raspberry powder, 0.5g of wolfberry powder, 1.2g of eucommia male pollen, 1g of morchella extract, 10g of oyster peptide powder, 10g of trace elements and 15g of fructo-oligosaccharide;
the trace elements comprise chelated zinc, chelated manganese, chelated copper and chelated iron, and the mass ratio of the chelated zinc to the chelated manganese to the chelated copper to the chelated iron is 1:0.6:0.2: 0.5;
(2) mixing and dispersing linseed oil powder, rice bran fatty alkanol, ossein peptide, stachyose, cordyceps militaris powder, L-carnitine and mulberry powder in water, and standing at normal temperature for 12 hours for later use;
(3) pulverizing rhizoma Polygonati, mixing with Ginseng radix powder, Rubi fructus powder, fructus Lycii powder, Eucommiae cortex pollen, Morchella esculenta extract, peptide powder and microelements, dispersing in 85% ethanol, heating ethanol at 80 deg.C for 10 hr, adding the water dispersion in step (2) into ethanol at a speed of 100r/min, and stirring for 20min to obtain a mixed solution;
(4) adding adjuvants into the mixed solution, centrifuging at 3000r/min for 10min, and filtering to remove residue;
(5) adjusting pH of the mixed solution to 5.5, freeze drying the mixed solution at-20 deg.C for 18h, and sterilizing the lyophilized powder at 110 deg.C with 365nm ultraviolet ray for 10min to obtain the composition for improving sperm activity.
Example 3
A composition for enhancing sperm motility:
(1) weighing 10g of linseed oil powder, 2g of rice bran fatty alkanol, 4g of collagen peptide, 2g of stachyose, 1g of rhizoma polygonati, 2g of taurine, 6g of cordyceps militaris powder, 3g of L-carnitine, 12g of mulberry powder, 1g of ginseng powder, 0.5g of raspberry powder, 0.7g of wolfberry powder, 0.5g of eucommia ulmoides male pollen, 8g of sea cucumber peptide powder, 12g of trace elements and 20g of isomaltooligosaccharide;
the trace elements comprise chelated zinc, chelated manganese, chelated copper and chelated iron, and the mass ratio of the chelated zinc to the chelated manganese to the chelated copper to the chelated iron is 1:0.4:0.3: 0.6;
(2) mixing and dispersing linseed oil powder, rice bran fatty alkanol, ossein peptide, stachyose, cordyceps militaris powder, L-carnitine and mulberry powder in water, and standing at normal temperature for 16 hours for later use;
(3) pulverizing rhizoma Polygonati, mixing with Ginseng radix powder, Rubi fructus powder, fructus Lycii powder, Eucommiae cortex male pollen, peptide powder and microelements, dispersing in 75% ethanol, heating ethanol at 60 deg.C for 12h, adding the water dispersion in step (2) into ethanol, stirring at 120r/min for 15min to obtain mixed solution;
(4) adding adjuvants into the mixed solution, centrifuging at 4000r/min for 8min, and filtering to remove residue;
(5) adjusting pH of the mixed solution to 6.5, freeze drying the mixed solution at-25 deg.C for 14h, and sterilizing the lyophilized powder at 110 deg.C with 365nm ultraviolet ray for 8min to obtain composition for improving sperm activity.
Example 4
A composition for enhancing sperm motility:
(1) pulverizing Morchella esculenta, sieving with a 120-mesh sieve, adding Morchella esculenta powder into 55% ethanol solution, and reflux-extracting at 85 deg.C for 10 hr to obtain Morchella esculenta extract;
weighing 12g of linseed oil powder, 2.2g of rice bran fatty alkanol, 5g of ossein peptide, 3g of stachyose, 0.8g of rhizoma polygonati, 2g of taurine, 7g of cordyceps militaris powder, 2g of L-carnitine, 22g of mulberry powder, 0.4g of ginseng powder, 0.6g of raspberry powder, 0.5g of wolfberry powder, 0.8g of eucommia male pollen, 2g of morchella esculenta extract, 8g of sea cucumber peptide powder, 13g of trace elements, 10g of isomaltooligosaccharide and 8g of fructo-oligosaccharide;
the trace elements comprise chelated zinc, chelated manganese, chelated copper and chelated iron, and the mass ratio of the chelated zinc to the chelated manganese to the chelated copper to the chelated iron is 1:0.5:0.2: 0.7;
(2) mixing and dispersing linseed oil powder, rice bran fatty alkanol, ossein peptide, stachyose, cordyceps militaris powder, L-carnitine and mulberry powder in water, and standing at normal temperature for 13 hours for later use;
(3) pulverizing rhizoma Polygonati, mixing with Ginseng radix powder, Rubi fructus powder, fructus Lycii powder, Eucommiae cortex pollen, Morchella esculenta extract, peptide powder and microelements, dispersing in 70% ethanol, heating ethanol at 70 deg.C for 15h, adding the water dispersion in step (2) into ethanol, stirring at 100r/min for 15min to obtain mixed solution;
(4) adding adjuvants into the mixed solution, centrifuging at 4500r/min for 7min, and filtering to remove residue;
(5) adjusting pH of the mixed solution to 7, freeze drying the mixed solution at-26 deg.C for 16h, and sterilizing the lyophilized powder at 110 deg.C with 365nm ultraviolet ray for 6min to obtain the composition for improving sperm activity.
Example 5
A composition for enhancing sperm motility:
(1) pulverizing Morchella esculenta, sieving with a 120-mesh sieve, adding Morchella esculenta powder into 55% ethanol solution, and reflux-extracting at 85 deg.C for 10 hr to obtain Morchella esculenta extract;
weighing 8g of linseed oil powder, 1.2g of rice bran fatty alkanol, 5g of ossein peptide, 2g of stachyose, 1.1g of rhizoma polygonati, 2g of taurine, 6g of cordyceps militaris powder, 4g of L-carnitine, 24g of mulberry powder, 0.7g of ginseng powder, 0.8g of raspberry powder, 0.6g of wolfberry powder, 1g of eucommia male pollen, 4g of morchella esculenta extract, 5g of oyster peptide powder, 15g of trace elements, 8g of isomaltooligosaccharide and 15g of fructo-oligosaccharide;
the trace elements comprise chelated zinc, chelated manganese, chelated copper and chelated iron, and the mass ratio of the chelated zinc to the chelated manganese to the chelated copper to the chelated iron is 1:0.4:0.3: 0.6;
(2) mixing and dispersing linseed oil powder, rice bran fatty alkanol, ossein peptide, stachyose, cordyceps militaris powder, L-carnitine and mulberry powder in water, and standing at normal temperature for 16 hours for later use;
(3) pulverizing rhizoma Polygonati, mixing with Ginseng radix powder, Rubi fructus powder, fructus Lycii powder, Eucommiae cortex pollen, Morchella esculenta extract, peptide powder and microelements, dispersing in 80% ethanol, heating ethanol at 75 deg.C for 12h, adding the water dispersion in step (2) into ethanol at 140r/min, and stirring for 18min to obtain a mixed solution;
(4) adding adjuvants into the mixed solution, centrifuging at 3500r/min for 6min, and filtering to remove residue;
(5) adjusting pH of the mixed solution to 7, freeze drying the mixed solution at-20 deg.C for 16h, and sterilizing the lyophilized powder at 110 deg.C with 365nm ultraviolet ray for 10min to obtain the composition for improving sperm activity.
Test example 1
Mixing the products of the examples 1-5 with deionized water according to the mass ratio of 1:20 to obtain a product water solution;
70 male SD rats were randomly divided into a control group, a model group and 10 rats in each of examples 1 to 5, wherein the control group and the examples 1 to 5 were used for preparing an oligospermia model by intraperitoneal injection of cyclophosphamide, and the model group was injected with physiological saline.
Rats of examples 1-5 were treated by gavage with 5ml of the aqueous solution of the product of examples 1-5 each time, and with 5ml of physiological saline for the control and model groups, and after one month of gavage, the rats were sacrificed, and plasma was collected and the contents of testosterone, follicle stimulating hormone, and luteinizing hormone were measured by chemiluminescence, and the results are shown in table 1.
According to the experimental results in table 1, compared with the control group, the levels of testosterone and luteinizing hormone in the model group are obviously increased, and the level of FSH is reduced, which indicates that cyclophosphamide can successfully construct a rat oligospermia model.
Compared with the model group, the results of the groups of examples 1 to 5 can obviously improve the contents of testosterone, follicle stimulating hormone and luteinizing hormone in the serum of the rat with oligospermia, and prove that the products of the groups of examples 1 to 5 can improve the sperm activity.
Test example 2
Case 1
Lijia, Shandong Weifang adult, 28 years old, unemployed two years after marriage, normal sexual life, examined, spouse normal, diagnosed: the survival rate of sperm one hour after sperm discharge is 20%. After the product in the embodiment 3 of the invention is taken for 15 days, the survival rate of sperms reaches 72 percent after one hour of sperm discharge.
Case 2
Congratulating, checking, showing that the spouse is normal and diagnosing, wherein the congratulation is normal, and the age of 29 years old, the unemployed person in the Shandong Qingdao is not born in the last year after marriage: the survival rate of sperm one hour after sperm discharge is 12%. After the product in the embodiment 4 of the invention is taken for 10 days, the survival rate of sperms reaches 80 percent after one hour of sperm discharge.
Case 3
Kaisai, Weihai people in Shandong, age 32, four years after marriage, sexual life normal, through examination, spouse normal, diagnosis: the survival rate of sperm one hour after sperm discharge is 15%. After the product of the invention in the embodiment 5 is taken for 30 days, the survival rate of sperms reaches 75 percent after one hour of sperm discharge.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.
Claims (10)
1. The composition for improving sperm activity is characterized by comprising the following raw materials in parts by weight: 5-15 parts of linseed oil powder, 1-3 parts of rice bran fatty alkanol, 2-6 parts of collagen peptide, 1-3 parts of stachyose, 0.5-2 parts of rhizoma polygonati, 1-3 parts of taurine, 4-8 parts of cordyceps militaris powder, 1-5 parts of L-carnitine, 10-25 parts of mulberry powder, 0.2-1.5 parts of ginseng powder, 0.2-1.5 parts of raspberry powder, 0.5-1 part of wolfberry powder, 0.3-1.2 parts of eucommia male pollen, 5-10 parts of peptide powder, 10-15 parts of trace elements and 15-25 parts of auxiliary materials.
2. The composition for enhancing sperm motility according to claim 1, wherein said peptide powder is oyster peptide powder or sea cucumber peptide powder.
3. A composition for enhancing sperm cell motility according to claim 1, wherein said trace elements include zinc chelates, manganese chelates, copper chelates, and iron chelates.
The mass ratio of the chelated zinc, the chelated manganese, the chelated copper and the chelated iron is 1 (0.3-0.6): (0.2-0.4): (0.5-0.8).
4. A composition for enhancing sperm motility according to claim 1, wherein said excipient is isomalto-oligosaccharide and/or fructo-oligosaccharide.
5. The composition for enhancing sperm motility according to claim 1, further comprising 1-5 parts of Morchella esculenta extract.
6. A method of preparing a composition for enhancing sperm motility, comprising the steps of:
(1) weighing the raw materials according to the parts by weight of any one of claims 1 to 5;
(2) mixing and dispersing linseed oil powder, rice bran fatty alkanol, ossein peptide, stachyose, cordyceps militaris powder, L-carnitine and mulberry powder in water, and standing at normal temperature for 12-18h to obtain a water dispersion for later use;
(3) pulverizing rhizoma Polygonati, mixing with Ginseng radix powder, vitamin E, fructus Lycii powder, Eucommiae cortex male pollen, peptide powder and microelements, dispersing in organic solvent, heating the organic solvent at 50-80 deg.C for 10-15h, adding the water dispersion in step (2) into the organic solvent, stirring and mixing to obtain mixed solution;
(4) adding auxiliary materials into the mixed solution, then centrifuging and filtering to remove residues;
(5) adjusting pH of the mixed solution to 5.5-7, freeze drying the mixed solution, and sterilizing the lyophilized powder to obtain the composition for improving sperm activity.
7. The method of claim 6, wherein the Morchella esculenta extract is prepared by:
pulverizing Morchella esculenta, sieving with 120 mesh sieve to obtain Morchella esculenta powder, adding into 55% ethanol solution, and reflux-extracting at 85 deg.C for 10 hr to obtain Morchella esculenta extract;
the morchella extract is dispersed in an organic solvent in the step (3).
8. A process for preparing a composition for enhancing sperm cell motility as claimed in claim 6, wherein said organic solvent in step (3) is ethanol at a concentration of 60-85%;
the stirring speed is 100-150r/min, and the stirring time is 10-20 min;
in the step (4), the centrifugation speed is 3000-5000r/min, and the centrifugation time is 5-10 min.
9. The method of claim 6, wherein the lyophilizing temperature is-30 to-20 ℃ and the lyophilizing time is 12-18h in step (5);
the sterilization method comprises the step of sterilizing for 5-10min by adopting ultraviolet rays with the wavelength of 365nm at the temperature of 110 ℃.
10. Use of a composition according to any of claims 1 to 5 for increasing sperm motility in the preparation of a functional food.
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