CN105901728A - Composition being helpful to postoperative recovery and preparation method of same - Google Patents
Composition being helpful to postoperative recovery and preparation method of same Download PDFInfo
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- CN105901728A CN105901728A CN201610250760.7A CN201610250760A CN105901728A CN 105901728 A CN105901728 A CN 105901728A CN 201610250760 A CN201610250760 A CN 201610250760A CN 105901728 A CN105901728 A CN 105901728A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to a composition being helpful to postoperative recovery, which includes the raw materials comprising, by weight, 3-5 parts of a ginseng extract, 5-10 parts of a poria cocos extract, 7-10 parts of cordyceps militaris powder, 3-5 parts of a blueberry extract, 10-15 parts of sea fish oligopeptide powder, 10-15 parts of soybean peptide powder, 5-10 parts of sea cucumber polypeptide, 5-10 parts of a radix angelicae extract, 5-10 parts of a fish oil extract, 2-3 parts of taurine, 2-3 parts of arginine, and 2-3 parts of glutamine, and as well as auxiliary materials including 3-5 parts of sucralose and 3-5 parts of stevioside. The invention also provides a preparation method of the composition. The composition, instead of intravenous injection, can be directly absorbed through stomach without digestion in gastrointestinal tract, wherein the components are combined and have synergistic effects in the aspects of supplying polypeptide nutrients, improving vitality of patients and improving body metabolism, thereby accelerating recovery and improving self-healing capability of the patients and preventing re-infection.
Description
Technical field
The present invention relates to field of health care products, a kind of compositions being beneficial to postoperative rehabilitation and preparation method thereof.
Background technology
Some operations bigger to injury of human, such as department of general surgery and thoracic surgery need patient opens abdomen or opens the wounds such as breast
Wound property is performed the operation, the successful one side of operation and doctor suitable operation and the most relevant in operation process, while with patient discharge after
Rehabilitation situation closely related.But, owing to, after the wound of operation, the vigour of patient declines, resistance, immunity simultaneously
Power and metabolic capacity all have reduction in various degree, largely have impact on the postoperative rehabilitation of patient, and serious the most easily feels
Dye, causes that sb.'s illness took a turn for the worse.The most gastral operation, the abilities of digestive and absorption of patient is greatly reduced.
Patient has just moved Post operation, and the nutrient pack based on immunoglobulin, aminoacid and mineral typically can be prepared by hospital, with
Intravenous mode inputs to patient, to strengthen the resistance of patient.But after patient discharge, general families of patients can prepare
Chicken, fish, pigeon, Stichopus japonicus etc. supplement the nutrients to patient.But, patient declines due to vigour, especially for organs such as the intestines and stomach
Carry out the patient performed the operation, bile cannot normal secretions, digestive and absorptive functions degradation, after having eaten above-mentioned food, not only digest
Not absorbing, nutrition does not catches up with, and recovers slowly, to take in a large amount of high protein, the food of high oils and fats, due to the digestion of the intestines and stomach simultaneously
Absorbability is not also recovered, and the intestines and stomach is formed serious burden, is unfavorable for the rehabilitation of patient.
The application for a patent for invention " a kind of postoperative rehabilitation Drug therapy formula " of Publication No. CN 105250828 A discloses a kind of art
Rear rehabilitation medicine treatment formula, by Fructus Lycii, Semen Sesami Nigrum, the Cortex Eucommiae, Radix Pseudostellariae, Rhizoma Drynariae, Radix Dipsaci, Radix Salviae Miltiorrhizae, Sanguis Draxonis, Fructus Crataegi,
Fructus Jujubae, Rhizoma Cyperi, brown sugar, Radix Ginseng, Cornu Cervi Pantotrichum, Placenta Hominis, Cordyceps, Rhizoma Polygonati, wheat tooth, Radix Glycyrrhizae, the Radix Astragali, Lignum Dalbergiae Odoriferae, fish
Raw meat grass, Medulla Leporis seu Oryctolagi, lichen, Tremella, Scorpio, silkworm, Pheretima, Rhizoma Gastrodiae, Radix Angelicae Sinensis and Rhizoma Chuanxiong composition.But, this formula is main
Being to make with pure Chinese medicine, medicament composing prescription is of a great variety, many rare medicinal herbss, and from the point of view of its background technology and beneficial effect, this
Invent mainly in accelerating wound healing, reduce pain, alleviate the scar vestige that wound stays, do not mention from all
On improve patient.
Summary of the invention
According to above-mentioned weak point, it is an object of the invention to provide one and can regulate physical function, beneficially postoperative rehabilitation comprehensively
Compositions and preparation method thereof.
For achieving the above object, technical program of the present invention lies in: a kind of compositions being beneficial to postoperative rehabilitation, count by weight,
Its raw material is Radix Ginseng extract 3-5 part, Poria extract 5-10 part, Cordyceps militaris (L.) Link. powder 7-10 part, blueberry extract 3-5 part, sea
Ocean fish oligopeptide powder 10-15 part, soy peptide powder 10-15 part, sea cucumber polypeptide 5-10 part, Radix Angelicae Dahuricae extract 5-10 part, fish oil carry
Take thing 5-10 part, taurine 2-3 part, arginase 12-3 parts, glutamine 2-3 part；Its adjuvant be sucralose 3-5 part,
Stevioside 3-5 part.
Preferably: its preparation technology of described Radix Ginseng extract is:
(1) Radix Ginseng appearance is cleaned rear pulverizing, dry Radix Ginseng powder is crossed 20-40 mesh aperture sieve；
(2) putting in container by Radix Ginseng powder, add entrainer, wherein, Radix Ginseng powder is 1:3-1:4 with the solid-liquid ratio of entrainer,
Put under room temperature condition in supersonic generator, ultrasonic 3-4h；
(3) being transferred in extractor by the material after ultrasonic, extraction temperature is 40-45 DEG C, and extraction time is 2-3 hour, extraction
Pressure power is 35MPa, CO2Flow velocity 12L/h；
(4) extracting solution enters the first separator through air relief valve, and the pressure of this separator is 6MPa, and temperature is 50-60 DEG C；
(5) extracting solution enters the second separator after the first separator, and the pressure of this separator is 2MPa, and temperature is 30-40 DEG C；
(6) make dry powder by freeze-dried for the material of extraction, obtain Radix Ginseng extract.
Preferably: described entrainer is the ethanol solution of 70%.
Preferably: its preparation technology of described Poria extract is:
(1) Poria appearance is cleaned rear pulverizing, dry Poria powder is crossed 20-40 mesh aperture sieve；
(2) Poria powder is put in container, add compound enzyme, add ultrasonic 30-40 minute of the water termostat of 45-55 DEG C, wherein
Poria powder is 1:1-1:2 with the solid-liquid ratio of pure water, and the addition of described compound enzyme is the 0.8-1.2% of Poria powder；
(3) ethanol solution precipitation is added after being concentrated by reactant liquor, centrifugal, taking precipitate；
(4) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(5) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
Preferably: described its preparation technology of Cordyceps militaris (L.) Link. powder is:
(1) Cordyceps militaris (L.) Link.sporophore is cleaned up rear drying and crushing, Cordyceps militaris (L.) Link. coarse powder is crossed 40-60 mesh aperture sieve；
(2) putting in container by Cordyceps militaris (L.) Link. coarse powder, the ratio with solid-liquid ratio as 1:5-10 adds pure water, and according to Cordyceps militaris (L.) Link.
Meal quality percentage ratio is that the ratio of 0.5-1.5% adds compound enzyme, in 35-55 DEG C of ultrasonic extraction 20-30min；
(3) rapidly temperature is increased to 80-100 DEG C after enzymolysis, is incubated 5-10min, by enzyme-deactivating；
(6) after enzyme-deactivating, reactant liquor being cooled to 50-60 DEG C, add ethanol solution precipitation after concentrating, centrifugal, it is heavy to take
Shallow lake thing；
(7) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(8) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
Preferably: the preparation technology of described Radix Angelicae Dahuricae extract is:
(1) pulverize after the Radix Angelicae Dahuricae being cleaned, and coarse powder is crossed 40-60 mesh aperture sieve；
(2) Radix Angelicae Dahuricae coarse powder ratio with solid-liquid ratio as 1:5-10 is added pure water, decoct 1-2h with 55-65 DEG C；
(3) cross leaching filtrate, be spray-dried after concentration, obtain Radix Angelicae Dahuricae extract.
Preferably: described marine fish its molecular weight of oligomeric Gly-His-Lys is less than 1000.
Preferably: its molecular weight of described soy peptide powder is less than 2000.
The present invention also provides for the preparation method of a kind of compositions being beneficial to postoperative rehabilitation, and it comprises the steps:
(1) weigh: weigh the amount of every kind of raw material according to the amount described in formula and individually deposit；
(2) pelletize: first by Radix Ginseng extract, Poria extract, Cordyceps militaris (L.) Link. powder, blueberry extract, the oligomeric Gly-His-Lys of marine fish,
Soy peptide powder, sea cucumber polypeptide, Radix Angelicae Dahuricae extract, taurine, arginine, glutamine move in efficient wet granulator and mix
After Jun Yun, add fish oil extract, again mix homogeneously, make granule；
(3) add sucralose, stevioside after raw material being made granule, sucralose and stevioside are uniformly coated with
Grain appearance；
(4) it is dried: wet granular is moved into Fast granulate machine dispersion and granulation, then moves in drying and granulating machine dry, until granule dries
Dry；
(5) granulate: dry granule is used Fast granulate machine granulate, is dispersed into uniform granule；
(6) tabletting: granule uses sheeting equipment carry out tabletting；
(7) packaging: using automatic packaging machine packaging, case after luggage box of going forward side by side again, warehouse-in preserves.
Radix Ginseng sweet in the mouth, micro-hardship, slightly warm in nature, return spleen, lung, the heart, kidney channel, gas Xiong Tirun, rise more than fall；There is invigorating QI to relieve exhaustion,
Strengthening spleen and tonifying lung, mind calming Fructus Alpiniae Oxyphyllae, effect of nourishing blood to promote the production of body fluid, be especially beneficial serious disease, prolonged illness, lose blood, vigour caused by de-liquid is intended to take off,
Mental fatigue faint pulse；Also contributing to improve the lack of appetite asthenia of deficiency of spleen-QI, vomiting is had loose bowels simultaneously；The dyspnea with shortness of breath of insufficiency of lung-QI, cough
Unable；The insomnia and dreamful sleep that insufficiency of heart-QI declines, palpitates with fear forgetful, body void hyperhidrosis；Body fluid deficiency thirsty, quenches one's thirst；Blood deficiency sallow, dizziness；
Impotence due to deficiency of the kidney, frequent micturition, the symptom such as deficiency of vital energy diseases caused by exogenous pathogenic factor.The Radix Ginseng extract extracted by supercritical liquid extraction technique, through two grades
Separate, be possible not only to extract ginsenoside, and ginseng polysaccharide can also be extracted so that the nutrient substance of Radix Ginseng is comprehensively carried
Take, and the composition extracted have action temperature and, all-ages feature, it is to avoid the full Radix Ginseng extract of use to part body heat,
The unaccommodated shortcomings of patient such as body is empty.
Poria sweet in the mouth, light, property is put down, GUIXIN, lung, spleen, kidney channel, eliminating dampness and diuresis；Invigorating the spleen and regulating the stomach；Mind tranquilizing and the heart calming.Poria is many
Sugar body the most all can strengthen the cytotoxic effect of T lymphocyte, strengthens body immunity.Poria can spleen invigorating, long to those
Sick thin and weak, inappetence or have fatigue and asthenia concurrently, the weak patient of deficiency of vital energy spleen of diarrhoea has the effect holding up spleen QI invigorating, and mild in medicine property and.
Cordyceps militaris (L.) Link. enters lung kidney two warp, can tonifying the lung cloudy, again can kidney-replenishing, cure mainly and suffer from a deficiency of the kidney, impotence and seminal emission, soreness of waist and knee joint, after being ill
Weakness, chronic cough is weak, and phthisical cough expectorant blood, spontaneous sweating etc., is a kind of Chinese medicine that can balance simultaneously, regulate negative and positive.
Containing substantial amounts of anthocyanidin in blue berry, free radical harmful in anthocyanidin energy purged body, free radical is to cause aging and many diseases
One of sick major reason, it is estimated that the aging of about 80-90%, degenerative disorders is all relevant with free radical, including cancer
Disease, senile dementia, Parkinson's disease, skin black speck deposition, cataract, heart disease etc., so eliminating harmful freedom
Base is most important for the health and youth keeping health.
The active collagen that the oligomeric Gly-His-Lys of marine fish extracts from the fish scale of fresh abyssal fishes, pure pollution-free；Use
The active polypeptide amino-terminal end of multiple enzyme directional cutting, mean molecule quantity is about 1000 dalton, and dissolubility is good, often
Can dissolve rapidly water under Wen, form homodisperse solution, human absorptivity is high；Raw material is strong with human body affinity, advanced
Processing technique makes marine fish oligopeptide keep original high activity.
Soy peptide powder bio-orientation enzymic hydrolysates, mean molecule quantity is less than 2000 dalton, is fully soluble in water, can be by human body
Directly, quickly, fully absorb, there is the whole protein nutrition quickly supplementing needed by human body, improve immunity；Quickly repair
Muscle injury, promotion wound healing；Regain one's strength, strengthen muscle strength, the function of raising motor capacity.
Stichopus japonicus, sweet-salty, the kidney invigorating, benefit marrow, take the photograph urine, flaccidity, its benefit warm in nature are treated in tonifying YANG.Stichopus japonicus have raising memory,
Delay gonad old and feeble, prevent arteriosclerosis and antitumor etc. from acting on.Utilizing biotechnology, it is multiple right to be extracted in Stichopus japonicus
Human body has raising immunity and the antioxidation biology special stereochemical structure aminoacid (levo form) of activity, substantially increases sea cucumber bio
Active component effect.
Radix Angelicae Dahuricae acrid in the mouth, warm in nature；Return lung, stomach, large intestine channel；Fragrance rises and dissipates；There is expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidify sensible,
Effect of detumescence and apocenosis；The Radix Angelicae Dahuricae can improve local blood circulation, eliminates pigment excess accumulation in the tissue, promotes Skin Cell
Metabolism, and then reach the effect of beauty treatment.
Fish oil extract is DHA and EPA extracted from shark oil.EPA has and helps to reduce containing of cholesterol and triglyceride
Amount, promotes the effect of internal saturated fat acid metabolic, thus reduces blood viscosity, promotes blood circulation, improves tissue oxygen supply
And allaying tiredness.DHA can suppress the formation of inflammation precursor, so having antiinflammation.DHA and EPA is big to improving
Brain nutrition and vessel softening and blood fat reducing have good action.
Taurine has another name called taurine, Taurine, names taurine by structure, is internal a kind of P aminoacid, belongs to non-egg
White matter aminoacid.Taurine can not be combined into protein with other aminoacid, but exists in a free form or and bile acid formation
Complex, huge uptake taurine there are no any side effect.It is mainly distributed on the higher tissue of irritability such as nervous system, flesh
In meat tissue, retina and lymphocytes and platelets.Taurine is the free amino acid that in heart, content is the abundantest, accounts for total
The 60% of amount.Taurine has close ties with cardiac muscle calcium and myocardial contraction.Taurine can increase the calcium of myocardial contraction phase utilization,
The prevention myocardial damage that causes of calcium overload, and occur without the side effect such as increased heart rate and arrhythmia in the treatment, controls being used for
When treating congestive heart failure, its clinical manifestation and cardiac status are clearly better, and also can significantly improve valvular ischemic cardiomyopathy
Hemodynamics.These functions are all very good for the long-term treatment of chronic heart failure especially gerontal patient.Except this it
Outward, in platelet, the concentration of taurine is the highest, about 400 600 times of blood plasma, and the taurine in platelet can suppress blood little
The coagulation of plate, has certain effect to the thromboembolism preventing the incident Collagen gathering of platelet from causing.Taurine can reduce blood
In liquid, cholesterol and the level of low-density lipoprotein cholesterol, improve High-density Lipoprotein-cholesterol simultaneously, and this is dynamic to prevention
Pulse atherosclerosis, coronary heart disease are useful.
It is the mesostate of ornithine cycle to arginine in vivo, can promote generation and the excretion of carbamide, correct ammonia intoxication
And can relieving liver stupor.Under some morbid state, such as wound, burn, resection of small intestine, pyemia, renal failure and
Tumors etc., may result in body and utilize arginine to be greatly increased, and when beyond body self generation amount, cause arginine to lack, when
During body nutrient Deficiency of Intake, these diseases will be increased the weight of.Research shows, the picked-up increase of arginine external source can improve nitrogen and put down
Weighing apparatus, improves lymphocyte function, and can stimulate arginine transhipment in liver.Can improve it addition, take arginine
Cardiovascular, lung, immunity and digestive function, and early carcinomatous change is had good preventive effect.Clinical research proves, essence ammonia
Acid can effectively improve hypertension, hyperlipidaemic conditions, and can significantly reduce diabetics level of lipid
Glutamine has important immunoregulation effect, and it is that lymphocytic emiocytosis, propagation and function thereof remain necessary.
As precursor and the main energy sources of Nucleic acid, glutamine can promote lymphocyte, the mitosis of macrophage and divide
Change propagation, increase the generation of cytokine TNF, IL-1 etc. and the mRNA synthesis of phospholipid.Offer exogenous glutamine can be bright
The ratio of CD4/CD8, the immune merit of enhancing body in the aobvious increase total lymphocyte count of critical patient, T lymphocyte and circulation
Energy.Glutamine (GLN) is non essential amino acid important in a kind of body, glutamine at aminoacid by α-one penta 2
Acid and glutamate pathway turn performance central role in amino metabolic process.Recently research have indicated that, GLN has immunomodulating and cell
Regulation effect.Research display glutamine effect glutathione synthesis precursor and purine and pyrimidine synthesize precursor, have cell function
Having many-sided regulation effect, such as GLN can regulate arginine and NO metabolism, can regulate cell volume and stimulating cytokine
Formed, regulate immune cell function, such as: stimulate interferon generations, inhibited apoptosis, increase interleukin generation,
Stimulate cell RNA synthesis etc..Precursor, GLN and cysteine, glycine, N-acetylcystein one is synthesized as GSH
Playing synthesis GSH, glutamine and cysteine act in kidney, liver, small intestinal redox metabolism and being even more important.
In the prescription of the present invention on the one hand, the oligomeric Gly-His-Lys of marine fish, soy peptide powder and sea cucumber polypeptide are micromolecule polypeptide, it is provided that
The nutrient substance that can directly absorb to patient, solves patient and can not draw the problem of nutrient from normal diet, by battalion
Support the supply of material, accelerate patients ' recovery and the lifting of self-healing ability.Second, ginseng qi-tonifying, improves patient due to vigour decline
And the problem that the rehabilitation ability caused reduces；Meanwhile, Cordyceps militaris (L.) Link. tonifying both YIN and YANG, can tonifying the lung through again can the kidney invigorating warp, carry further
Rise the vigour of patient, add Poria, triple interaction, improve the immunity of patient, it is to avoid infect in rehabilitation course or be subject to
The invasion of other pathogens, produces other focuses.The Radix Angelicae Dahuricae can help wound evacuation of pus pain relieving, improves the discomfort that postoperative wound causes.The
Three, blue berry and fish oil extract have the strongest oxidation resistance, remove interior free yl, interact with Radix Ginseng, improve generation
Thank, improve metabolic function.4th, taurine, arginine and glutamine contribute to the rehabilitation of function of human body.5th, Poria
Invigorating the spleen and regulating the stomach, improves gastrointestinal function, strengthens absorbing of complete nutrients matter.
The beneficial effects of the present invention is: the compositions of the present invention is not by intravenous injection, but passes through stomach, and need not
Through the nutrient substance that pipe intestinal digesting just can directly absorb.The interphase interaction of each component, from supplementary many peptides nutrient substance,
Promote patient's vigour, improve body metabolism three broad aspect and mutually regulate, accelerate the rehabilitation of patient and improve its self-healing ability, prevention
Subinfection again.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
A kind of compositions being beneficial to postoperative rehabilitation, counts by weight, and its raw material is Radix Ginseng extract 3 parts, Poria extract 5
Part, 7 parts of Cordyceps militaris (L.) Link. powder, blueberry extract 3 parts, the oligomeric Gly-His-Lys of marine fish 10 parts, soy peptide powder 10 parts, sea cucumber polypeptide 5
Part, Radix Angelicae Dahuricae extract 5 parts, fish oil extract 5 parts, taurine 2 parts, arginase 12 part, glutamine 2 parts；Its adjuvant
For sucralose 3 parts, stevioside 3 parts.Wherein, its molecular weight of the oligomeric Gly-His-Lys of marine fish is less than 1000.Its point of soy peptide powder
Son amount is less than 2000.
Wherein, its preparation technology of Radix Ginseng extract is:
(1) Radix Ginseng appearance is cleaned rear pulverizing, dry Radix Ginseng powder is crossed 20 mesh aperture sieve；
(2) putting in container by Radix Ginseng powder, add entrainer, wherein, Radix Ginseng powder is 1:3 with the solid-liquid ratio of entrainer, in room
Put under the conditions of temperature in supersonic generator, ultrasonic 3h；Entrainer is the ethanol solution of 70%.
(3) being transferred in extractor by the material after ultrasonic, extraction temperature is 40 DEG C, and extraction time is 2 hours, extraction pressure
Power is 35MPa, CO2Flow velocity 12L/h；
(4) extracting solution enters the first separator through air relief valve, and the pressure of this separator is 6MPa, and temperature is 50 DEG C；
(5) extracting solution enters the second separator after the first separator, and the pressure of this separator is 2MPa, and temperature is 30 DEG C；
(6) make dry powder by freeze-dried for the material of extraction, obtain Radix Ginseng extract.
Its preparation technology of Poria extract is:
(1) Poria appearance is cleaned rear pulverizing, dry Poria powder is crossed 20 mesh aperture sieve；
(2) Poria powder is put in container, add compound enzyme, add ultrasonic 30 minutes of the water termostat of 45 DEG C, wherein Poria powder
Being 1:1 with the solid-liquid ratio of pure water, the addition of described compound enzyme is the 0.8% of Poria powder；
(3) ethanol solution precipitation is added after being concentrated by reactant liquor, centrifugal, taking precipitate；
(4) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(5) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
Its preparation technology of Cordyceps militaris (L.) Link. powder is:
(1) Cordyceps militaris (L.) Link.sporophore is cleaned up rear drying and crushing, Cordyceps militaris (L.) Link. coarse powder is crossed 40 mesh aperture sieve；
(2) putting in container by Cordyceps militaris (L.) Link. coarse powder, the ratio with solid-liquid ratio as 1:5 adds pure water, and thick according to Cordyceps militaris (L.) Link.
Powder mass percent is the ratio addition compound enzyme of 0.5%, in 35 DEG C of ultrasonic extraction 20min；
(3) rapidly temperature is increased to 80 DEG C after enzymolysis, is incubated 5min, by enzyme-deactivating；
(6) after enzyme-deactivating, reactant liquor is cooled to 50 DEG C, after concentrating, adds ethanol solution precipitation, centrifugal, take precipitation
Thing；
(7) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(8) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
The preparation technology of Radix Angelicae Dahuricae extract is:
(1) pulverize after the Radix Angelicae Dahuricae being cleaned, and coarse powder is crossed 40 mesh aperture sieve；
(2) Radix Angelicae Dahuricae coarse powder ratio with solid-liquid ratio as 1:5 is added pure water, decoct 1h with 55 DEG C；
(3) cross leaching filtrate, be spray-dried after concentration, obtain Radix Angelicae Dahuricae extract.
The present invention also provides for the preparation method of the beneficially compositions of postoperative rehabilitation, and it comprises the steps:
(1) weigh: weigh the amount of every kind of raw material according to the amount described in formula and individually deposit；
(2) pelletize: first by Radix Ginseng extract, Poria extract, Cordyceps militaris (L.) Link. powder, blueberry extract, the oligomeric Gly-His-Lys of marine fish,
Soy peptide powder, sea cucumber polypeptide, Radix Angelicae Dahuricae extract, taurine, arginine, glutamine move in efficient wet granulator and mix
After Jun Yun, add fish oil extract, again mix homogeneously, make granule；
(3) add sucralose, stevioside after raw material being made granule, sucralose and stevioside are uniformly coated with
Grain appearance；
(4) it is dried: wet granular is moved into Fast granulate machine dispersion and granulation, then moves in drying and granulating machine dry, until granule dries
Dry；
(5) granulate: dry granule is used Fast granulate machine granulate, is dispersed into uniform granule；
(6) tabletting: granule uses sheeting equipment carry out tabletting；
(7) packaging: using automatic packaging machine packaging, case after luggage box of going forward side by side again, warehouse-in preserves.
Embodiment 2
A kind of compositions being beneficial to postoperative rehabilitation, counts by weight, and its raw material is Radix Ginseng extract 5 parts, Poria extract 10
Part, 10 parts of Cordyceps militaris (L.) Link. powder, blueberry extract 5 parts, the oligomeric Gly-His-Lys of marine fish 15 parts, soy peptide powder 15 parts, sea cucumber polypeptide
10 parts, Radix Angelicae Dahuricae extract 10 parts, fish oil extract 10 parts, taurine 3 parts, arginine 3 parts, glutamine 3 parts；Its
Adjuvant is sucralose 5 parts, stevioside 5 parts.Wherein, its molecular weight of the oligomeric Gly-His-Lys of marine fish is less than 1000.Soy peptide powder
Its molecular weight is less than 2000.
Wherein, its preparation technology of Radix Ginseng extract is:
(1) Radix Ginseng appearance is cleaned rear pulverizing, dry Radix Ginseng powder is crossed 40 mesh aperture sieve；
(2) putting in container by Radix Ginseng powder, add entrainer, wherein, Radix Ginseng powder is 1:4 with the solid-liquid ratio of entrainer, in room
Put under the conditions of temperature in supersonic generator, ultrasonic 4h；Entrainer is the ethanol solution of 70%.
(3) being transferred in extractor by the material after ultrasonic, extraction temperature is 45 DEG C, and extraction time is 3 hours, extraction pressure
Power is 35MPa, CO2Flow velocity 12L/h；
(4) extracting solution enters the first separator through air relief valve, and the pressure of this separator is 6MPa, and temperature is 60 DEG C；
(5) extracting solution enters the second separator after the first separator, and the pressure of this separator is 2MPa, and temperature is 40 DEG C；
(6) make dry powder by freeze-dried for the material of extraction, obtain Radix Ginseng extract.
Its preparation technology of Poria extract is:
(1) Poria appearance is cleaned rear pulverizing, dry Poria powder is crossed 40 mesh aperture sieve；
(2) Poria powder is put in container, add compound enzyme, add ultrasonic 40 minutes of the water termostat of 55 DEG C, wherein Poria powder
Being 1:2 with the solid-liquid ratio of pure water, the addition of described compound enzyme is the 1.2% of Poria powder；
(3) ethanol solution precipitation is added after being concentrated by reactant liquor, centrifugal, taking precipitate；
(4) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(5) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
Its preparation technology of Cordyceps militaris (L.) Link. powder is:
(1) Cordyceps militaris (L.) Link.sporophore is cleaned up rear drying and crushing, Cordyceps militaris (L.) Link. coarse powder is crossed 60 mesh aperture sieve；
(2) putting in container by Cordyceps militaris (L.) Link. coarse powder, the ratio with solid-liquid ratio as 1:10 adds pure water, and according to Cordyceps militaris (L.) Link.
Meal quality percentage ratio is the ratio addition compound enzyme of 1.5%, in 55 DEG C of ultrasonic extraction 30min；
(3) rapidly temperature is increased to 100 DEG C after enzymolysis, is incubated 10min, by enzyme-deactivating；
(6) after enzyme-deactivating, reactant liquor is cooled to 60 DEG C, after concentrating, adds ethanol solution precipitation, centrifugal, take precipitation
Thing；
(7) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(8) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
The preparation technology of Radix Angelicae Dahuricae extract is:
(1) pulverize after the Radix Angelicae Dahuricae being cleaned, and coarse powder is crossed 60 mesh aperture sieve；
(2) Radix Angelicae Dahuricae coarse powder ratio with solid-liquid ratio as 1:10 is added pure water, decoct 2h with 65 DEG C；
(3) cross leaching filtrate, be spray-dried after concentration, obtain Radix Angelicae Dahuricae extract.
The present invention also provides for the preparation method of the beneficially compositions of postoperative rehabilitation with embodiment 1.
Embodiment 3
A kind of compositions being beneficial to postoperative rehabilitation, counts by weight, and its raw material is Radix Ginseng extract 4 parts, Poria extract 7
Part, 8 parts of Cordyceps militaris (L.) Link. powder, blueberry extract 4 parts, the oligomeric Gly-His-Lys of marine fish 12 parts, soy peptide powder 13 parts, sea cucumber polypeptide 8
Part, Radix Angelicae Dahuricae extract 8 parts, fish oil extract 7 parts, taurine 2 parts, arginine 3 parts, glutamine 2 parts；Its adjuvant
For sucralose 4 parts, stevioside 4 parts.Wherein, its molecular weight of the oligomeric Gly-His-Lys of marine fish is less than 1000.Its point of soy peptide powder
Son amount is less than 2000.
Wherein, its preparation technology of Radix Ginseng extract is:
(1) Radix Ginseng appearance is cleaned rear pulverizing, dry Radix Ginseng powder is crossed 30 mesh aperture sieve；
(2) putting in container by Radix Ginseng powder, add entrainer, wherein, Radix Ginseng powder is 1:3 with the solid-liquid ratio of entrainer, in room
Put under the conditions of temperature in supersonic generator, ultrasonic 3.5h；Entrainer is the ethanol solution of 70%.
(3) being transferred in extractor by the material after ultrasonic, extraction temperature is 42 DEG C, and extraction time is 2.3 hours, extraction pressure
Power is 35MPa, CO2Flow velocity 12L/h；
(4) extracting solution enters the first separator through air relief valve, and the pressure of this separator is 6MPa, and temperature is 55 DEG C；
(5) extracting solution enters the second separator after the first separator, and the pressure of this separator is 2MPa, and temperature is 35 DEG C；
(6) make dry powder by freeze-dried for the material of extraction, obtain Radix Ginseng extract.
Its preparation technology of Poria extract is:
(1) Poria appearance is cleaned rear pulverizing, dry Poria powder is crossed 30 mesh aperture sieve；
(2) Poria powder is put in container, add compound enzyme, add ultrasonic 35 minutes of the water termostat of 45-55 DEG C, wherein Poria
Powder is 1:1 with the solid-liquid ratio of pure water, and the addition of described compound enzyme is the 1% of Poria powder；
(3) ethanol solution precipitation is added after being concentrated by reactant liquor, centrifugal, taking precipitate；
(4) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(5) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
Its preparation technology of Cordyceps militaris (L.) Link. powder is:
(1) Cordyceps militaris (L.) Link.sporophore is cleaned up rear drying and crushing, Cordyceps militaris (L.) Link. coarse powder is crossed 50 mesh aperture sieve；
(2) putting in container by Cordyceps militaris (L.) Link. coarse powder, the ratio with solid-liquid ratio as 1:7 adds pure water, and thick according to Cordyceps militaris (L.) Link.
Powder mass percent is the ratio addition compound enzyme of 1%, in 45 DEG C of ultrasonic extraction 25min；
(3) rapidly temperature is increased to 90 DEG C after enzymolysis, is incubated 8min, by enzyme-deactivating；
(6) after enzyme-deactivating, reactant liquor is cooled to 55 DEG C, after concentrating, adds ethanol solution precipitation, centrifugal, take precipitation
Thing；
(7) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(8) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
The preparation technology of Radix Angelicae Dahuricae extract is:
(1) pulverize after the Radix Angelicae Dahuricae being cleaned, and coarse powder is crossed 50 mesh aperture sieve；
(2) Radix Angelicae Dahuricae coarse powder ratio with solid-liquid ratio as 1:7 is added pure water, decoct 1.5h with 60 DEG C；
(3) cross leaching filtrate, be spray-dried after concentration, obtain Radix Angelicae Dahuricae extract.
The present invention also provides for the preparation method of the beneficially compositions of postoperative rehabilitation, and preparation method is with embodiment 1.
Effect experimental, specific experiment is carried out with the compositions being beneficial to postoperative rehabilitation that prescription described in embodiment 3 and preparation method prepare
As follows.
1, mouse immune experiment
The preparation of experiment reagent: take the compositions that the prescription with embodiment 3 and preparation method prepare, dissolves after pulverizing, joins respectively
Make 0.4,0.8, the solution of 1.6mg/ml, now with the current.
Animal packet and model are set up: take healthy Kunming mouse 48, body weight 18-20g, male and female half and half, be randomly divided into four groups,
Often group 12, respectively Normal group, high dose group, middle dosage group, low dose group, every day gavage 1 time, each 0.5ml,
Normal group gives pure water, the composition solution of other variable concentrations that gavage prepares the most respectively, continuous gavage 15 days.
Serum hemolysin measures: after 15 days, disconnected neck is put to death, and eyeball takes blood, separates serum, and 1:300 times dilutes, and takes dilute serum
1ml adds 0.5mlSRBC and 1ml complement, and 37 DEG C of water-baths terminate reaction, and 2000r/min is centrifuged 10 minutes, takes supernatant 1ml
Adding 3ml all formula reagent to shake up, after 10 minutes, hemoglobin weaves into cyanohemoglobin, 540nm colorimetric.Operate control tube equally
With SRBC half oozing of blood pipe, by following equation result of calculation: sample HC50The OD value of=sample/half SRBC haemolysis
OD value × extension rate.
Immune Organs Index measures: takes and dissects after blood is weighed, take spleen and thymus is weighed, sterile working, calculates by following equation
Result: organ index=internal organs weight (mg)/body weight (g).
T lymphocyte transformation is tested: aseptic take mouse spleen, shreds with operating scissors, sieves with 200 nylon wires, makes slender
Born of the same parents' suspension, adds Ficoll-hypaque centrifugation lymphocyte.Adjusting cell concentration with CM is 5 × 106/ ml, adds ConA
Final concentration of 10 μ g/ml.Taking the 96 every holes of orifice plate Tissue Culture Plate and add 200 μ l cell suspension, every sample sets three wells, and
If CM control wells.Through 37 DEG C, 5%CO2After saturated humidity cultivates 48h, every hole adds MTT solution (5mg/ml) 20 μ l,
Continue to cultivate 4h, go supernatant, every hole to add 200 μ l0.04N hydrochloric acid isopropanols with plate centrifuge and dissolve.Examine with enzyme linked immunological
Survey instrument and measure OD value with wavelength 570nm, 630nm respectively.
Experimental result is shown in Table 1.
Table 1 mouse immune experimental result situation summary sheet
| Group | HC50 | Index and spleen index | Thymus index | ODλ=570 | ODλ=630 |
| Normal group | 0.42±0.04 | 49.11±7.89 | 34.89±4.89 | 0.051±0.039 | 0.121±0.129 |
| High dose group | 0.55±0.08** | 137.25±33.81 | 35.11±1.23 | 0.354±0.101** | 0.452±0.182* |
| Middle dosage group | 0.49±0.06* | 109.64±49.12* | 31.79±7.23 | 0.238±0.029 | 0.342±0.159* |
| Low dose group | 0.45±0.07 | 88.98±41.22 | 30.86±3.23 | 0.118±0.058* | 0.245±0.418* |
Note: with Normal group ratio, * * P ＜ 0.01, * P ＜ 0.05.
From mouse experiment it can be seen that humoral immunization and the cellular immunization of mice are all improved to some extent by the present composition,
Illustrate that this compositions has the function improving immunity.
2, human experimentation
Choosing out breast, open abdomen, open the patient 180 of the operation such as cranium, men and women does not limits, and the age does not limits, and is divided into three groups, often organizes 60
, one group of matched group refuses to obey this compositions, and two groups start to take this compositions until 3 months after operation from postoperative, and three groups from preoperative 1
Start to take the present composition week until 3 months after operation.Preoperative take every day 2 times, each 1, every 0.65g, postoperative
In 1 week, every day takes 3 times, each takes 3, and after one week, every day takes 3 times, each takes 2.Respectively at preoperative,
Preoperative, postoperative take this compositions 1 week and after 3 months measure immunity five, liver function 13, and follow the tracks of observation patient wound
Mouth healing state, physical recovery situation.
Experimental result is shown in Table 2.
Table 2 human experimentation result situation summary sheet
According to the result of above-mentioned tracking test, from the point of view of immunity five, illustrate that this compositions can improve the immunity of patient.From
From the point of view of liver function 13, illustrate that this compositions can improve the metabolism of patient.Extensive from follow-up wound healing situation and health
From the point of view of multiple situation, illustrate that this compositions can be greatly improved the several of the rehabilitation ability of patient, minimizing postoperative infection or other complication
Rate, largely contributes to the rehabilitation of patient and the raising of self-healing ability.
On the other hand, from the contrast of preoperative beginning compositions and postoperative beginning compositions it can be seen that preoperative just take this compositions,
The health of patient can be adjusted, be favorably improved the immunity of patient, can preferably tackle operation for vitality of human body
Destroy, and convalescence can be shortened further, be also more favorable for postoperative rehabilitation simultaneously.
Claims (9)
1. one kind be beneficial to postoperative rehabilitation compositions, it is characterised in that: count by weight, its raw material be Radix Ginseng extract 3-5 part,
Poria extract 5-10 part, Cordyceps militaris (L.) Link. powder 7-10 part, blueberry extract 3-5 part, marine fish oligomeric Gly-His-Lys 10-15 part, Semen sojae atricolor
Gly-His-Lys 10-15 part, sea cucumber polypeptide 5-10 part, Radix Angelicae Dahuricae extract 5-10 part, fish oil extract 5-10 part, taurine 2-3 part,
Arginase 12-3 parts, glutamine 2-3 part；Its adjuvant is sucralose 3-5 part, stevioside 3-5 part.
The most according to claim 1 be beneficial to postoperative rehabilitation compositions, it is characterised in that: described Radix Ginseng extract its prepare work
Skill is:
(1) Radix Ginseng appearance is cleaned rear pulverizing, dry Radix Ginseng powder is crossed 20-40 mesh aperture sieve；
(2) putting in container by Radix Ginseng powder, add entrainer, wherein, Radix Ginseng powder is 1:3-1:4 with the solid-liquid ratio of entrainer, in room temperature
Under the conditions of put in supersonic generator, ultrasonic 3-4h；
(3) being transferred in extractor by the material after ultrasonic, extraction temperature is 40-45 DEG C, and extraction time is 2-3 hour, extraction pressure
Power is 35MPa, CO2Flow velocity 12L/h；
(4) extracting solution enters the first separator through air relief valve, and the pressure of this separator is 6MPa, and temperature is 50-60 DEG C；
(5) extracting solution enters the second separator after the first separator, and the pressure of this separator is 2MPa, and temperature is 30-40 DEG C；
(6) make dry powder by freeze-dried for the material of extraction, obtain Radix Ginseng extract.
The compositions being beneficial to postoperative rehabilitation the most according to claim 2, it is characterised in that: described entrainer is the ethanol of 70%
Solution.
The most according to claim 1 be beneficial to postoperative rehabilitation compositions, it is characterised in that: described Poria extract its prepare work
Skill is:
(1) Poria appearance is cleaned rear pulverizing, dry Poria powder is crossed 20-40 mesh aperture sieve；
(2) Poria powder is put in container, add compound enzyme, add ultrasonic 30-40 minute of the water termostat of 45-55 DEG C, wherein Poria
Powder is 1:1-1:2 with the solid-liquid ratio of pure water, and the addition of described compound enzyme is the 0.8-1.2% of Poria powder；
(3) ethanol solution precipitation is added after being concentrated by reactant liquor, centrifugal, taking precipitate；
(4) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(5) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
The compositions being beneficial to postoperative rehabilitation the most according to claim 1, it is characterised in that: described its preparation technology of Cordyceps militaris (L.) Link. powder
For:
(1) Cordyceps militaris (L.) Link.sporophore is cleaned up rear drying and crushing, Cordyceps militaris (L.) Link. coarse powder is crossed 40-60 mesh aperture sieve；
(2) putting in container by Cordyceps militaris (L.) Link. coarse powder, the ratio with solid-liquid ratio as 1:5-10 adds pure water, and according to Cordyceps militaris (L.) Link. coarse powder
Mass percent is that the ratio of 0.5-1.5% adds compound enzyme, in 35-55 DEG C of ultrasonic extraction 20-30min；
(3) rapidly temperature is increased to 80-100 DEG C after enzymolysis, is incubated 5-10min, by enzyme-deactivating；
(6) after enzyme-deactivating, reactant liquor is cooled to 50-60 DEG C, after concentrating, adds ethanol solution precipitation, centrifugal, taking precipitate；
(7) precipitate uses dehydrated alcohol, acetone wash according to this, the precipitate pure water after washing is redissolved；
(8) solution is dialysed, take filtrate and be spray-dried, obtain Poria extract.
The compositions being beneficial to postoperative rehabilitation the most according to claim 1, it is characterised in that: the preparation work of described Radix Angelicae Dahuricae extract
Skill is:
(1) pulverize after the Radix Angelicae Dahuricae being cleaned, and coarse powder is crossed 40-60 mesh aperture sieve；
(2) Radix Angelicae Dahuricae coarse powder ratio with solid-liquid ratio as 1:5-10 is added pure water, decoct 1-2h with 55-65 DEG C；
(3) cross leaching filtrate, be spray-dried after concentration, obtain Radix Angelicae Dahuricae extract.
The compositions being beneficial to postoperative rehabilitation the most according to claim 1, it is characterised in that: described marine fish its point of oligomeric Gly-His-Lys
Son amount is less than 1000.
The compositions being beneficial to postoperative rehabilitation the most according to claim 1, it is characterised in that: its molecular weight of described soy peptide powder is low
In 2000.
The preparation method of the compositions being beneficial to postoperative rehabilitation the most according to claim 1, it is characterised in that: it comprises the steps:
(1) weigh: weigh the amount of every kind of raw material according to the amount described in formula and individually deposit；
(2) pelletize: first by Radix Ginseng extract, Poria extract, Cordyceps militaris (L.) Link. powder, blueberry extract, the oligomeric Gly-His-Lys of marine fish, Semen sojae atricolor
Gly-His-Lys, sea cucumber polypeptide, Radix Angelicae Dahuricae extract, taurine, arginine, glutamine move into mix homogeneously in efficient wet granulator
After, add fish oil extract, again mix homogeneously, make granule；
(3) sucralose, stevioside are added after raw material being made granule, by outside uniform to sucralose and stevioside coated particle
Table；
(4) it is dried: wet granular is moved into Fast granulate machine dispersion and granulation, then moves in drying and granulating machine dry, until granule is dried；
(5) granulate: dry granule is used Fast granulate machine granulate, is dispersed into uniform granule；
(6) tabletting: granule uses sheeting equipment carry out tabletting；
(7) packaging: using automatic packaging machine packaging, case after luggage box of going forward side by side again, warehouse-in preserves.
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| CN107549692A (en) * | 2017-09-26 | 2018-01-09 | 大连大学 | A kind of ocean polypeptide spy's dietary seafood for patients undergoing chemotherapy post-operative recovery |
| CN109567167A (en) * | 2018-12-25 | 2019-04-05 | 梁力中 | A kind of alimentation composition and its preparation method and application containing Pseudobulbus Bletillae (Rhizoma Bletillae) extract suitable for pre-operative patients |
| CN110584129A (en) * | 2019-10-18 | 2019-12-20 | 成都鲵肽生物科技有限公司 | Giant salamander polypeptide powder composition for tumor rehabilitation |
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