CN112516274A

CN112516274A - Pharmaceutical composition for treating malignant lymphoma and application thereof

Info

Publication number: CN112516274A
Application number: CN202011536996.XA
Authority: CN
Inventors: 马宇振; 马俊鹏; 邢盼盼; 马腾飞
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-12-23
Filing date: 2020-12-23
Publication date: 2021-03-19

Abstract

The invention belongs to a pharmaceutical composition for treating malignant lymphoma and application thereof; the pharmaceutical composition is prepared from the following raw materials: radix astragali, parched Atractylodis rhizoma, Poria, radix Panacis Quinquefolii, bupleuri radix, radix Curcumae, rhizoma Cyperi, rhizoma Sparganii, Curcumae rhizoma, Bulbus Fritillariae Cirrhosae, Pumex, Prunellae Spica, caulis Lonicerae, radix Platycodi, Notoginseng radix, semen Persicae, endothelium corneum Gigeriae Galli, carapax Trionycis, ramulus Cinnamomi, Scorpio, radix Puerariae, Saviae Miltiorrhizae radix, Scolopendra, Lumbricus and Bombyx Batryticatus; used for treating malignant lymphoma, and has the advantages of low cost, stable quality control, obvious treatment effect and high cure rate.

Description

Pharmaceutical composition for treating malignant lymphoma and application thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for treating malignant lymphoma and application thereof.

Background

Malignant lymphoma is a general term of a group of malignant tumors originating from a lymphohematopoietic system, and has the main clinical manifestations of painless lymphadenectasis, hepatosplenomegaly, all tissues and organs of the whole body can be affected, and before or at the same time of discovering the lymphadenectasis, general symptoms such as fever, night sweat, emaciation, skin pruritus and the like can appear. Lymphomas are classified into non-Hodgkin's lymphoma (NHL) and Hodgkin's Lymphoma (HL) according to their pathology, clinical characteristics, prognosis outcome, and the like. At present, the main treatment means of the western medicine aiming at the malignant lymphoma is a mode of combining chemotherapy and drug therapy, the mode is high in cost, the symptoms are treated, the root causes are not treated, and the patient's own immune system is greatly damaged; in the existing traditional Chinese medicine field, the defects of unobvious treatment effect, delayed effect and the like exist in the treatment of malignant lymphoma, and the defects cause that a large number of malignant lymphoma patients or family members are not willing to use traditional Chinese medicine for treatment or use traditional Chinese medicine for inhibiting tumor growth.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provides the pharmaceutical composition for treating malignant lymphoma, which has the advantages of low cost, stable quality control, obvious treatment effect and high cure rate, and the application thereof.

The purpose of the invention is realized as follows: the pharmaceutical composition is prepared from the following raw materials: astragalus root, rhizoma atractylodis macrocephalae, tuckahoe, American ginseng, radix bupleuri, radix curcumae, rhizoma cyperi, rhizoma sparganii, rhizoma zedoariae, bulbus fritilariae, pumice, selfheal, honeysuckle stem, platycodon grandiflorum, pseudo-ginseng, peach kernel, endothelium corneum gigeriae galli, turtle shell, cassia twig, scorpion, radix puerariae, radix salviae miltiorrhizae, centipede, earthworm and stiff silkworm.

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 9-30 parts of astragalus membranaceus, 6-12 parts of coked bighead atractylodes rhizome, 10-15 parts of poria cocos, 3-6 parts of American ginseng, 3-10 parts of radix bupleuri, 3-10 parts of radix curcumae, 6-10 parts of rhizoma cyperi, 5-10 parts of rhizoma sparganii, 6-10 parts of curcuma zedoary, 3-10 parts of bulbus fritilariae, 9-15 parts of bryozoatum, 9-15 parts of selfheal, 9-30 parts of honeysuckle stem, 3-10 parts of platycodon grandiflorum, 9-10 parts of pseudo-ginseng, 5-10 parts of peach kernel, 3-10 parts of endothelium corneum gigeriae galli, 9-24 parts of turtle shell, 3-10 parts of cassia twig, 3-6 parts of scorpion, 9-15 parts of radix puerariae, 10-15 parts of salvia miltiorrhiza, 3-5 parts of centipede.

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 9-21 parts of astragalus membranaceus, 6-9 parts of coked bighead atractylodes rhizome, 13-15 parts of poria cocos, 3-6 parts of American ginseng, 3-7 parts of radix bupleuri, 5-10 parts of radix curcumae, 6-10 parts of rhizoma cyperi, 5-7 parts of rhizoma sparganii, 6-8 parts of curcuma zedoary, 8-10 parts of bulbus fritilariae, 13-15 parts of bryozoatum, 9-13 parts of selfheal, 21-30 parts of honeysuckle stem, 5-10 parts of platycodon grandiflorum, 9-10 parts of pseudo-ginseng, 8-10 parts of peach kernel, 3-5 parts of endothelium corneum gigeriae galli, 16-24 parts of turtle shell, 5-10 parts of cassia twig, 3-6 parts of scorpion, 9-15 parts of radix puerariae, 10-12 parts of salvia miltiorrhiza, 3-5 parts of centipede.

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 7 parts of coked bighead atractylodes rhizome, 14 parts of poria cocos, 6 parts of American ginseng, 7 parts of radix bupleuri, 9 parts of radix curcumae, 9 parts of rhizoma cyperi, 5 parts of rhizoma sparganii, 6 parts of curcuma zedoary, 10 parts of bulbus fritilariae, 15 parts of pumice, 9 parts of selfheal, 30 parts of honeysuckle stem, 5 parts of platycodon grandiflorum, 10 parts of pseudo-ginseng, 10 parts of peach kernel, 4 parts of endothelium corneum gigeriae galli, 20 parts of turtle shell, 5 parts of cassia twig, 6 parts of scorpion, 14 parts of radix puerariae, 10 parts of radix salviae miltiorrhiza.

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 22-30 parts of astragalus membranaceus, 10-12 parts of coked bighead atractylodes rhizome, 10-12 parts of poria cocos, 3-6 parts of American ginseng, 8-10 parts of radix bupleuri, 3-5 parts of radix curcumae, 6-10 parts of rhizoma cyperi, 8-10 parts of rhizoma sparganii, 9-10 parts of curcuma zedoary, 3-7 parts of bulbus fritilariae, 9-12 parts of pumice, 14-15 parts of selfheal, 9-20 parts of honeysuckle stem, 3-4 parts of platycodon grandiflorum, 9-10 parts of pseudo-ginseng, 5-7 parts of peach kernel, 6-10 parts of endothelium corneum gigeriae galli, 9-15 parts of turtle shell, 3-4 parts of cassia twig, 3-6 parts of scorpion, 9-15 parts of radix puerariae, 13-15 parts of salvia miltiorrhiza, 3-5 parts of centipede.

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 28 parts of astragalus membranaceus, 10 parts of coked bighead atractylodes rhizome, 11 parts of poria cocos, 4 parts of American ginseng, 8 parts of radix bupleuri, 5 parts of radix curcumae, 7 parts of rhizoma cyperi, 9 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 6 parts of bulbus fritilariae, 11 parts of bryozoatum, 14 parts of selfheal, 15 parts of honeysuckle stem, 3 parts of platycodon grandiflorum, 10 parts of pseudo-ginseng, 6 parts of peach kernel, 9 parts of endothelium corneum gigeriae galli, 13 parts of turtle shell, 4 parts of cassia twig, 5 parts of scorpion, 14 parts of radix puerariae, 13 parts of radix salviae milt.

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 25 parts of astragalus membranaceus, 10 parts of coked bighead atractylodes rhizome, 13 parts of poria cocos, 6 parts of American ginseng, 10 parts of radix bupleuri, 10 parts of radix curcumae, 10 parts of rhizoma cyperi, 9 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 9 parts of bulbus fritilariae, 14 parts of pumice, 15 parts of selfheal, 30 parts of honeysuckle stem, 10 parts of platycodon grandiflorum, 9 parts of pseudo-ginseng, 9 parts of peach kernel, 10 parts of endothelium corneum gigeriae galli, 23 parts of turtle shell, 10 parts of cassia twig, 6 parts of scorpion, 15 parts of radix puerariae, 13 parts of radix salviae miltiorrhiza.

The invention provides application of the pharmaceutical composition in preparing a pharmaceutical composition for treating malignant lymphoma.

The malignant lymphoma diseases indicated in the invention are complicated in deficiency and excess, the traditional Chinese medicine considers that the malignant lymphoma is mainly caused by invasion of exogenous pathogenic factors, internal injury of seven emotions, internal deficiency of vital qi and dysfunction of internal organs, and exogenous pathogenic factors of four-time abnormal qi and six excesses are causes, and the 'treatment method for dorsal furuncle' indicates that the patient is not painful but is diffused, and the patient is also suffered from deficiency of both qi and blood, and is also suffered from coagulation of toxic phlegm, qi and blood. "this indicates that the occurrence of this disease is closely related to the deficiency of the zang-fu organs, qi and blood deficiency, phlegm-toxin coagulation, qi stagnation and blood stasis. The evolution law of the liver-qi stagnation type phlegm-heat-toxin type liver-qi stagnation type liver-qi. The impairment of the function of kidney qi transformation caused by the decrease of the functions of liver and kidney, generally speaking, the water failing to distribute and gather dampness into phlegm, which combines with qi, blood and body fluids to form nuclei. Based on the problems, the invention adopts the monarch drug which is the monarch drug and is used for softening hardness and dissipating stagnation, breaking blood and eliminating mass, activating blood and dissolving stasis, dissipating stagnation and eliminating phlegm by using the salvia miltiorrhiza, the peach kernel, the common burreed rhizome, the zedoary, the turtle shell, the bulbus fritilariae and the pumice; radix astragali, radix Panacis Quinquefolii, ramulus Cinnamomi, rhizoma Atractylodis Macrocephalae preparata, Poria, radix Platycodi, endothelium corneum Gigeriae Galli, and radix Puerariae have effects of invigorating qi and nourishing blood, invigorating lung and descending, invigorating spleen and benefiting stomach, coordinating spleen and lung, and normalizing function of spleen in transporting and transforming water and dampness, and lung in regulating and regulating water passage; radix bupleuri, radix curcumae, rhizoma cyperi, selfheal and honeysuckle stem are used as adjuvant drugs for soothing liver-qi stagnation and clearing heat; scorpion, centipede, earthworm, batryticated silkworm, meridian passage dredging, toxin counteracting and stagnation dissipating are used as guiding drugs. In a word, the traditional Chinese medicine composition disclosed by the invention can be used for removing blood stasis, promoting blood circulation to remove blood stasis, dissipating stagnation and eliminating phlegm, eliminating focus as a monarch drug, tonifying qi and nourishing blood, tonifying lung and descending, tonifying spleen and tonifying stomach, conditioning spleen and lung, enabling spleen to transport and transform water-dampness function and lung to dredge and regulate water passage function to be normal as ministerial drugs, soothing liver and relieving depression, clearing heat to be adjuvant drugs, dredging collaterals, counteracting toxic substances and dissipating stagnation as conductant drugs, enabling stubborn diseases to be eliminated, enabling all organs to be normal, and particularly enabling water liquid to be normal in distribution, so that the root; furthermore, the cassia twig used in the Chinese traditional medicine has the function of gasification, and can lead the waste liquid to be discharged from urine.

The traditional Chinese medicine can be directly obtained from the market. The invention can be decocted or the raw materials are respectively crushed, sieved and mixed according to the parts by weight, and then the mixture is filled into capsules or pressed into tablets; or mixing with pharmaceutically acceptable carrier or diluent, and making into capsule or tablet. The invention is mainly used for treating malignant lymphoma; taking decoction as an example, one dose is taken every day, the decoction is decocted with water for three times, and about 840ml of juice is taken, and the juice is taken separately in the morning, the noon and the evening. One month is a treatment course, the rest is 4 days between two treatment courses, and the next treatment course is carried out, and generally 3 treatment courses are continuously taken; after the clinical symptoms and physical signs disappear, three treatment courses are consolidated; in particular, special groups such as pregnant women need to follow medical advice when taking the medicine, and no special adverse reaction is found at present. Treatment according to the present invention means treatment after onset of disease and does not represent intervention prior to onset of disease.

The traditional Chinese medicine composition is used for treating malignant lymphoma diseases, comprises 25 traditional Chinese medicines which are all directly obtained from markets, and has the following pharmacological and medicinal properties:

astragalus root: sweet and warm in flavor. Entering lung and spleen meridians, the main function is: to replenish qi and strengthen the middle-jiao. Can be used for treating qi deficiency, asthenia, anorexia, and loose stool. It is usually combined with Dang Shen for tonifying qi.

Charred rhizoma Atractylodis Macrocephalae: sweet and bitter in flavor and warm in nature. It enters spleen and stomach meridians. The efficacy is as follows: invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. The application comprises the following steps: 1. can be used for treating spleen qi deficiency, anorexia, loose stool, abdominal distention, listlessness, asthenia, etc. due to dysfunction of transportation and transformation. 2. It can be used for treating phlegm retention and edema due to spleen deficiency and retention of water and dampness. 3. Can be used for treating spleen deficiency, qi deficiency, and spontaneous perspiration due to weak muscle surface. 4. Can be used for treating spleen deficiency and qi deficiency during pregnancy, and threatened abortion.

Tuckahoe, poria cocos: sweet and bland in flavor and mild in nature. It enters heart, lung, spleen and kidney meridians. The efficacy is as follows: induce diuresis and drain dampness, invigorate spleen and calm heart. The main treatment is as follows: can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

American ginseng: sweet, slightly bitter and cool. (new materia Medica): slightly bitter and sweet, cold. ② Rev of materia Medica: sweet and pungent taste, cool nature and no toxicity. The "Renzai of materia Medica": enter heart, lung and kidney meridians. The functional indications are as follows: nourish lung yin, clear deficiency fire, promote the production of body fluid to quench thirst. It is indicated for chronic cough due to lung deficiency, blood loss, dry throat, thirst, deficiency heat, restlessness and fatigue. (new materia Medica): tonify lung to descend fire, generate body fluids, relieve restlessness and fatigue. It is suitable for deficiency with fire. ② examination of drug Property: tonify yin and abate fever. Ginger processed product has effects of invigorating qi, and strengthening body resistance. ③ renewal of materia medica: it is indicated for hyperactivity of lung fire, cough with excessive phlegm, qi deficiency with dyspnea, blood loss, overstrain, essence-securing and tranquilization, and various deficiency of productive process. Fourthly, the materia medica ask for the original: clearing lung and kidney, cooling heart and spleen to reduce pathogenic fire, relieving summer heat, and relieving hangover.

Bupleurum root: pungent and bitter in flavor and slightly cold in nature. It enters liver, gallbladder and lung meridians. The efficacy is as follows: harmonize exterior and interior, soothe liver, relieve depression, raise yang, lift sinking, allay fever and check malaria. The main treatment is as follows: can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and proctoptosis.

Turmeric root-tuber: pungent, bitter and cold in nature. It enters liver, heart and lung meridians. The efficacy is as follows: promoting blood circulation to arrest pain, promoting qi circulation to relieve depression, clearing away heart-fire, cooling blood, promoting bile flow, and eliminating jaundice. The main treatment is as follows: can be used for treating pricking pain in chest and hypochondrium, thoracic obstruction, cardialgia, amenorrhea, dysmenorrhea, breast pain, coma due to fever, epilepsy, hematemesis, hemorrhage, jaundice, and dark urine.

Rhizoma cyperi: pungent, slightly bitter, slightly sweet and mild in nature. It enters liver, spleen and triple energizer meridians. The efficacy is as follows: to soothe the liver, relieve depression, regulate qi, relieve epigastric distention, regulate menstruation and alleviate pain. The main treatment is as follows: can be used for treating stagnation of qi due to depression of the liver, distending pain in chest and hypochondrium, hernia pain, breast pain, stagnation of qi in spleen and stomach, abdominal distention, fullness and pain, menoxenia, amenorrhea, and dysmenorrhea. The related compatibility application: 1. relieving all kinds of depression: rhizoma Atractylodis, rhizoma Cyperi, rhizoma Ligustici Chuanxiong, Massa Medicata Fermentata, and fructus Gardeniae. In the form of powder, the water pill is as big as mung bean. One hundred pills are taken per dose. (Yueju Wan from Danxi Xin Fa) 2, for phlegm-stopping and fluid retention, wind-qi attacking upwards and obstructing the chest and diaphragm: rhizoma Cyperi (fructus Gleditsiae Abnormalis with water), rhizoma Pinelliae each with one or two, and Alumen powder with half two. Ginger juice is a paste pill, and Chinese parasol is a big one. Three pills and forty pills are taken every time, and ginger decoction is added at any time. (Renzuchantang experience prescription) 3, treating migraine and headache: two rhizoma ligustici wallichii and two rhizoma cyperi, and four rhizoma cyperi (fried) and two rhizoma cyperi. The upper part is powder. The preserved tea is particularly good when taken after being mixed with tea. (peaceful Bihuo Square) 4, treating hematemesis: the cyperus rotundus powder or the bletilla striata powder is convenient to be taken for children. (Danxi Zhi Fa Xin Yao) 5, treating urine and hematuria: the cyperus rotundus and the ulmus pumila are decocted into soup respectively in equal parts. Taking rhizoma Cyperi decoction three and five quads first, and then radix Sangusorbae decoction until it is completely consumed, and taking again after no effect. (Quansheng Zhi Mi Fang) 6, for treating metrorrhagia and metrostaxis with blood deficiency or five colors: rhizoma Cyperi (dehaired, slightly parched) is in powder form. Two coins are taken every time, and the clear rice is drunk and adjusted. (prescription of this affair) 7, treating prolapse of anus: rhizoma Cyperi and herba Schizonepetae are divided into powder. Three spoons of water are used each time, a large bowl of water is used, boiled for tens of times and poured. ("Sanyin Fang" Xiang Jing san).

Three-edge: pungent, bitter and even in flavor. Entering liver and spleen meridians, the efficacy is: break blood and move qi, resolve food stagnation and alleviate pain. The main treatment is as follows: can be used for treating abdominal mass, dysmenorrhea, blood stasis, amenorrhea, thoracic obstruction, heart pain, and pain due to food stagnation. Related compatibility: 1. amber powder: stop bleeding and promote tissue regeneration, relieve heart fire and improve eyesight, break mass of qi in the abdomen, cause postpartum blood faint and oppression, and cause infantile occipital pain, and it is suitable for being used as a bait. Decocting and smashing amber, turtle shell, rhizoma sparganii, rhizoma corydalis, myrrh and rheum officinale into powder. The hollow wine is taken with Sanqian an ancient type of spoon for daily use. Shen Mo He. Reducing radix et rhizoma Rhei after parturition. ("Hai Yao Ben Cao)" 2, Qi attacking head pain: the common fenugreek seed (fried), the common burreed rhizome (soaked and baked with wine) are half and half respectively, the dried ginger (processed) is half and half, and the ginger soup or the warm wine is taken twice. (Jisheng Fang) 3. milk does not fall: three rhizoma sparganii is used, the water is used for two bowls, the juice is decocted for one bowl, and the milk is washed to obtain the juice, so that the milk is very wonderful.

Zedoary turmeric: pungent and bitter with warm nature. It enters liver and spleen meridians. The efficacy is as follows: move qi and break blood, resolve food stagnation and alleviate pain. The main treatment is as follows: can be used for treating blood, qi and heart pain, food stagnation, abdominal distention and pain, amenorrhea due to blood stagnation, dysmenorrhea, abdominal mass, tumor, and traumatic injury. Related compatibility: 1. for qi of small intestine, intolerable pain in non-season: the Kaempferia pandurata is ground into powder, and the wine is taken with the hollow green onion for one money. (compendium, quote Yang Zi Jian Ming Fang) 2, treating woman's blood stasis and blood clots, amenorrhea: zedoary, burred tuber, rhizoma sparganii, cooked rhubarb, and radix et rhizoma Rhei. The pills are as big as mung beans, twenty pills are taken every time, and the white soup is added. (cautions Zhai Yi Shu) 3, treating puerperal cold and pain in the heart and abdomen: zedoary, trogopterus dung, and vinegar. Pounded Rou is added into powder, decocted with vinegar into paste, and then made into pills like those of phoenix tree seed. When not used, the Huaixiang soup or the hot wine is added to prepare ten pills. (prescription of general relief) 4, treating traumatic pain: zedoary, white muscardine silkworm, sappan wood, myrrh. Is powder. Two changes are taken each time, the decoction is taken, and three or five days are taken. (Kangfuye san from Boji Fang) 5, for treating paint sore: it is decocted with Peng E Zhu and guan Zhong to wash.

Tendril-leaved fritillary bulb: bitter and sweet in taste, slightly cold in nature. It enters lung and heart meridians. Has the effects of clearing heat, moistening lung, eliminating phlegm, relieving cough, resolving masses and eliminating carbuncle. The main treatment is as follows: can be used for treating lung heat dry cough, dry cough with little phlegm, cough due to yin deficiency, bloody sputum, scrofula, acute mastitis, and pulmonary abscess. Related compatibility: 1. for pulmonary abscess and pulmonary atrophy: bulbus Fritillariae Cirrhosae two, concretio silicea Bambusae seu Schizostachyi, Borax one money each, and Meretrix meretrix Linnaeus (stir-fried with vinegar) five times. The powder is prepared by decocting folium Eriobotryae (cleaned by brushing and stir-frying with honey) to obtain paste, and making into pill, semen euryales is large, and has the effect of clearing away heat and throat. (Bei mu shou Tan Wan from Yi Jie) 2, for hematemesis, epistaxis, or even onset or cessation, they are all caused by heart storing heat: one or two of fritillary bulb (bai ling huang). Pounding finely into powder, and adjusting two money with warm slurry when not counting. (Shenghui Fang) 3, treating difficulty in urination and defecation during pregnancy, and eating for reasons: four or two of fritillary bulb, lightyellow sophora root and Chinese angelica. The three flavors are added, and the powder is refined into honey pills which are as big as small beans. Three pills are drunk and added into ten pills. (Danggui Bei mu Ku Shen Wan from jin Kui Yao L ü e) 4, lactation: oyster, anemarrhena rhizome and fritillary bulb. The three materials are ground into fine powder and mixed with the pig trotter soup. Contraindications are as follows: it should not be combined with Chuan Wu, Ku Fu Wu, Chuan Kusnezo Wu and Fu Zi. Records in the West of medical science: can tonify qi system and tonify blood system.

Pumice stone: salty and cold. Enter lung and kidney meridians. The functional indications are as follows: clear lung fire, resolve old phlegm, soften hard mass and treat stranguria. It is indicated for cough due to phlegm-heat, accumulation of old phlegm, goiter, scrofula, gonorrhea, hernia, sore and nebula. Ceramic carry landscape: relieving cough. ② Ben Cao Shi Yi: mainly thirsty. ③ Rihuazi Ben Cao: quench thirst, treat stranguria and kill wild animal poison. Fourthly, the materia Medica is derived: refined with water, indicated for nebula in eyes. Juzhenheng: clear the gold, lower fire, remove mass and resolve old phlegm. Sixthly, compendium: eliminate goiter, tumor, tuberculosis, hernia, descending qi, and sores and swelling. Seventhly, the materia medica treatment: promoting digestion, eliminating heat-phlegm, relieving fever and thirst with heat stranguria, relieving cough with phlegm and dyspnea, softening hard masses, and inducing diuresis and dampness. Or made into pill or powder. External use: grind into powder or spray into eyes.

Selfheal: pungent, bitter and cold in nature. It enters liver and gallbladder meridians. Has the effects of clearing liver-fire, improving eyesight, resolving masses and relieving swelling. The main indications are red, swollen and painful eyes, luminous pain of eyes, headache and dizziness, scrofula, goiter, mammary abscess, mammary nodules and breast distending pain. Use with cautions to pay attention to the spleen and stomach cold.

Honeysuckle stem: sweet and cold in flavor. It enters lung and stomach meridians. Has the effects of clearing away heat and toxic materials, dispelling wind and dredging collaterals. The main indications are epidemic febrile disease fever, heat toxin and bloody dysentery, carbuncle swelling, sore and ulcer, rheumatism and heat arthralgia, and joint inflammation and pain. Use notice: it is contraindicated in cases of diarrhea due to deficiency-cold of spleen and stomach.

Balloon flower: bitter and pungent in property and mild in nature. It enters lung meridian. The efficacy is as follows: disperse lung qi, relieve sore throat, dispel phlegm, and expel pus. The main treatment is as follows: can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, and purulent vomiting. Related compatibility: 1. nausea in pregnancy, pain in the heart and abdomen: root of balloonflower, one for two (file). One water, three ginger slices, six minutes of decoction and warm taking. (Shenghui Fang) 2, for pulmonary abscess manifested as fullness in chest, cold-shaking, rapid pulse, dry throat without thirst, turbid saliva with stinking smell, and pus like rice gruel for a long time: one for platycodon root and two for liquorice. The second medicine is taken after being boiled with three liters of water, and the medicine is taken after being warmed. (balloon flower decoction in golden Kui Yao L ü e) 3, for cough with phlegm and dyspnea with urgency: two halves of platycodon grandiflorum. Pounding into powder, half rising with boy's urine, decocting to get four parts, removing residues, and taking warm. Contraindications are as follows: it is contraindicated for qi movement reversal, vomiting, cough, vertigo, cough due to yin deficiency with effulgent fire, etc. because of its ascending nature and dispersing. Nausea and vomiting are easily caused by excessive dosage.

Pseudo-ginseng: sweet, slightly bitter and warm in taste. It enters liver and stomach meridians. The efficacy is as follows: disperse blood stasis, stop bleeding, resolve swelling and alleviate pain. The main treatment is as follows: can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain. Related compatibility: 1. hematemesis and epistaxis: sanqiyiqian, chewed by itself and sent with rice soup. Or adding eight-core decoction in five parts. (simplified prescription of Binhu Ji) 2, infantile typhoid fever, and strong fever in whooping. Using a turnrow for a weight, burning till, using water for two buckets, quenching pseudo-ginseng for times, decocting half, adding willow leaf seven tablets, and bathing. Take powder 1-3 g once. Proper dosage is for external application. Contraindications are as follows: use with cautions for pregnant women. Discussion of interest 1, compendium of materia Medica: stop bleeding, disperse blood and relieve pain, incised wound, traumatic injuries, canker sores and persistent bleeding, and stop bleeding when they are chewed or mixed. It is also indicated for hematemesis, epistaxis, bloody dysentery, metrorrhagia, profuse menstruation, postpartum lochiorrhea, blood-moving pain, red eye, carbuncle and swelling, and snake bite. 2. The herbal Zhenzhen: it is specially used for liver and stomach. It also enters heart and large intestine. Also known as paint. The time is rare. Or cloud-energy alloy sores. Such as paint stickers. 3. The herbal supplement: disperse blood and relieve pain. It is indicated for hematemesis and epistaxis. Dysentery with bloody stool and metrorrhagia. Blood-shot eyes, abscess and swelling. 4. [1] compendium of materia Medica supplement (1765): ginseng, radix Ginseng and Notoginseng are the most valuable Chinese herbs because they tonify qi the first and tonify blood the first, and both the flavor and action of Notoginseng are the same.

Peach kernel: bitter, sweet and mild in nature. It enters heart, liver and large intestine meridians. The efficacy is as follows: promote blood circulation to remove blood stasis, moisten intestines to relieve constipation, relieve cough and relieve asthma. The main treatment is as follows: can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, intestinal dryness, constipation, cough, and asthma. Related compatibility: 1. pediatric malaria: wumaojia shiqian and seven peach kernels are decocted together, and the patients are healed after taking one decoction (Wen Ju Shi Fang) 2, and the patients are regurgitated and vomited: one black-bone chicken is drunk with water for four or five days without eating. Cutting Wupu snake into two pieces, and cutting with bamboo knife. When the chicken is dung, the chicken is dried in the shade to be powder, and the water-bindered pill is big with the maize. One part is taken every time, and the peach kernel is added with decoction. The five seven drugs are taken orally to cure the disease. (invention for syndrome) 3, fishing qi in dish intestine: half two peach kernels and a little aconite, stir-frying, removing the aconite, adding the dahurian angelica root, and taking the mixture as powder. Half of money is taken every time, and fennel and scallion stalk are added in wine. Contraindications are as follows: it should be used with cautions for pregnant women and loose stool.

Endothelium corneum gigeriae galli: sweet and mild in taste. It enters spleen, stomach, small intestine and bladder meridians. The efficacy is as follows: strengthening the stomach to promote digestion, arresting seminal emission and relieving enuresis, and treating stranguria and removing calculus. The main treatment is as follows: can be used for treating dyspepsia, emesis, dysentery, infantile malnutrition, enuresis, nocturnal emission, stranguria with stone, pain, gallbladder distention, and hypochondriac pain. Related compatibility: 1. thirst quenching and water diversion, those with one stone in the day: the spinach root and the chicken's gizzard-membrane are equally divided into powder. Rice is drunk for one money and three days. (experience prescription) 2, incision sore: the effect is immediately achieved when the chicken's gizzard-skin is burnt to ash and applied. (Hui Xiao Xin Shu) 3, erosion of vulval head and malnutrition: the endothelium corneum Gigeriae Galli (without falling into water) is cleaned, and the new tile is baked to be crisp and becomes fire-toxin, and is pulverized into fine powder. The sore is washed with rice swill and then applied. It is also indicated for aphtha. The effect of powder is better than the effect of decoction. Contraindications are as follows: it should be used with cautions for spleen deficiency without stagnation. Related discussion: 1. compendium of materia Medica: for removing alcohol accumulation, it is taken with bean powder pill. 2. The Yunnan herbal medicine: to strengthen the spleen, to promote digestion and grind the stomach. For children, food stagnation, big belly, green muscle and abdomen, malnutritional stagnation 3, this meridian meets the former: it is indicated for nebula.

Turtle shell: salty in taste and slightly cold in nature. It enters liver and kidney meridians. The efficacy is as follows: nourish yin and suppress yang, defervesce and remove steaming, soften hardness and dissipate nodulation. It is mainly used for treating fever due to yin deficiency, bone-steaming, fatigue-heat, yin deficiency, yang hyperactivity, dizziness, blurred vision, internal stirring of deficient wind, amenorrhea, abdominal mass, chronic malaria, and malaria. Compatibility 1, treating urolithic stranguria: the turtle shell is ground into powder and then treated with an ancient type of spoon cun in the prescription of being taken with wine, two or three days later, and then mixed with the stone for the patient to be healed. (posterior cubitus) 2, for carbuncle, deep-rooted carbuncle and abscess without astringency, all sores on the back: carapax Trionycis for retention after being burned, ground and mixed. Contraindications are as follows: deficiency-cold of spleen and stomach, poor appetite, loose stool and prohibited use by pregnant women.

Cassia twig: pungent and sweet in flavor and warm in nature. It enters lung, heart and bladder meridians. The efficacy is as follows: induce sweating to relieve exterior syndrome, dispel cold to alleviate pain, activate yang to regulate qi. Can be used for treating common cold due to wind-cold, pain due to cold accumulation and blood stagnation, phlegm retention, water retention syndrome, and palpitation. Related compatibility: it is combined with Bai Shao for wind-cold, exterior deficiency and sweating. ② it is combined with Zhi Shi and Xie Bai for treating chest yang deficiency, heart vessel stasis, chest stuffiness and pain. ③ Dang Gui and Wu Zhu Yu are used together for treating women's cold accumulation, blood stagnation, irregular menstruation, amenorrhea, dysmenorrhea and postpartum abdominal pain. Fourthly, it is combined with Fu Ling, Zhu Ling and ze Xie to treat failure of bladder qi transformation, edema and dysuria. Wu Fu is combined with Fu Zi for arthralgia due to wind-cold-dampness and pain of shoulder and arm. Contraindications are as follows: gui Zhi is pungent in flavor and warm in property, easy to move yin and move blood, so it is contraindicated in cases of exogenous febrile disease, hyperactivity of fire due to yin deficiency, recklessly blood flow due to blood heat, etc. It should be used with cautions for pregnant women and those with excessive menstruation.

Scorpion: pungent and even. It enters liver meridian. The efficacy is as follows: extinguish wind and relieve spasm, dredge collaterals and alleviate pain, counteract toxic pathogen and dissipate nodulation. The main treatment is as follows: can be used for treating liver wind stirring, spasm, convulsion, infantile convulsion, and apoplexy

Hemiplegia, tetanus, stubborn rheumatism, migraine, sore and ulcer, scrofula. Related compatibility: 1. toothache is difficult to endure: seven of Fu Zi Jian, Tian Xia Jian and quan Xie are ground into powder and then spotted. (Yong type prescription) 2, infantile epilepsy: a little of amber and cinnabar respectively, one scorpion. Is powder. The ophiopogon decoction is taken in a word. (Directu prescriptions) 3, vomiting wind for children: the primary vomiting is not. Two seven cicada slough and two seven scorpion (detoxified) are used. Is powder. Adding a little calomel and regulating and filling milk.

Kudzu root: sweet and pungent in flavor and cool in nature. It enters lung and stomach meridians. The efficacy is as follows: expelling pathogenic factors from muscles and skin, bringing down fever, promoting eruption, promoting the production of body fluid, quenching thirst, invigorating yang, and relieving diarrhea. The main treatment is as follows: can be used for treating fever due to exterior syndrome, pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging, and diarrhea due to spleen deficiency. Related compatibility: 1. headache with seasonal qi and high fever: cleaning radix Puerariae, mashing into juice, mixing with black beans, decocting for six minutes, removing residues, and treating with sweating. It is taken after sweating. For heart heat, add twelve Zhizi kernels. (Shenghui Fang) 2, preventing febrile disease, and acute scouring rush wind: two liters of kudzu powder, one liter of dried rehmannia root and half liter of fermented soya bean. Is in the form of powder. The formula an ancient type of spoon is drunk every time after eating rice, and three days after eating rice. It is taken orally for five patients. (Pan an frequent "typhoid treatise") 3, and Diamias are not infected: the juice of raw kudzu is taken as small cup, and the heat-toxin and gas are removed. (Shenghui Fang) 4, dysphoria and hot thirst: four or two of arrowroot, half liter of millet is soaked by water, and the mixture is percolated out overnight, stirred evenly and cooked into porridge. (Shenghui Fang) 5, retching without rest: pounding radix Puerariae into juice, taking one liter, and treating. It should be contraindicated for deficiency-cold patients and used with cautions for stomach-cold vomiting.

Red sage root: red sage root: bitter and slightly cold in taste. Meridian tropism: it enters heart and liver meridians. The efficacy is as follows: promoting blood circulation, dispelling blood stasis, dredging meridians, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle. The main treatment is as follows: can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain. Related compatibility: 1. it is indicated for irregular menstruation, or before or after, more or less, threatened abortion before delivery, and persistent lochiorrhea after delivery, and also for cold and hot bleeding during abortion: twelve red sage roots and twelve red sage roots, five liters of wine, three liters of wine, one liter of wine for warm taking and three liters of wine for one day. Or decocting in water. (Qianjinprescription) 2, hernia of cold and abdominal pain: the middle aspect of the lower abdomen is painful, whitish and sweaty, and the patient wants to die. One or two of the salvia miltiorrhiza are used as powder. Two coins are taken every time, and the hot wine is adjusted. (Shenghui Fang) 3, heat-oil burning, pain-relieving and granulation-promoting: eight or two rasps of salvia miltiorrhiza are taken, fine adjustment is carried out by water, two jin of mutton tallow is taken, three jin are decocted, three yuan are decocted, and the three jin are used for being smeared on sores. It is stir-baked with wine for activating blood and resolving stasis.

Centipede: pungent and warm in flavor. It enters liver meridian. The efficacy is as follows: extinguish wind and relieve spasm, dredge collaterals and alleviate pain, counteract toxic pathogen and dissipate nodulation. The main treatment is as follows: can be used for treating stirring of liver wind, spasm, convulsion, infantile convulsion, apoplexy, hemiplegia, tetanus, rheumatism, headache, pyocutaneous disease, lymphoid tuberculosis, and snake and insect bite. Related compatibility: 1. ceiling convulsion: the chronic retention of eyes, white eyes, and the reversed angle of the eyes, which are caused by the failure of voice, are mainly due to the double-golden powder. Removing head and feet with one big centipede, stir-frying with a crisp cake, cutting with a bamboo knife, and recording. Musk, Moschus, recorded in the right and left directions, is ground into powder and packaged. The left one should blow the left nose and the right one should blow the right nose, a little bit of each. If the eyes are not dropped, the patient blows a few palpitations, and the eyes are stopped. (direct prescription) 2. women's toe sore: the protrusion of malignant flesh in the nail is not cured. One centipede is baked and ground for external application. The powder of arisaema tuber and vinegar are applied to the periphery. Contraindications are as follows: it is forbidden for pregnant women.

Earthworm: pungent and warm in flavor. It enters liver meridian. The efficacy is as follows: extinguish wind and relieve spasm, dredge collaterals and alleviate pain, counteract toxic pathogen and dissipate nodulation. The main treatment is as follows: can be used for treating stirring of liver wind, spasm, convulsion, infantile convulsion, apoplexy, hemiplegia, tetanus, rheumatism, headache, pyocutaneous disease, lymphoid tuberculosis, and snake and insect bite. Related compatibility: 1. ceiling convulsion: the chronic retention of eyes, white eyes, and the reversed angle of the eyes, which are caused by the failure of voice, are mainly due to the double-golden powder. Removing head and feet with one big centipede, stir-frying with a crisp cake, cutting with a bamboo knife, and recording. Musk, Moschus, recorded in the right and left directions, is ground into powder and packaged. The left one should blow the left nose and the right one should blow the right nose, a little bit of each. If the eyes are not dropped, the patient blows a few palpitations, and the eyes are stopped. (direct prescription) 2. women's toe sore: the protrusion of malignant flesh in the nail is not cured. One centipede is baked and ground for external application. The powder of arisaema tuber and vinegar are applied to the periphery. Contraindications are as follows: it is forbidden for pregnant women.

Stiff silkworm: salty and pungent with mild natures. It enters liver, lung and stomach meridians. The efficacy is as follows: extinguish wind and stop spasm, dispel wind and alleviate pain, resolve phlegm and dissipate nodulation. The main treatment is as follows: can be used for treating liver wind with phlegm, epilepsy and convulsion, infantile acute convulsion, tetanus and apoplexy

Headache due to wind-heat, conjunctival congestion, pharyngalgia, pruritus due to rubella, and parotitis. Related compatibility: 1. treating facial distortion and hemiplegia due to apoplexy: baifuzi, Jiang Can and quan Xie are divided into equal parts (unprocessed). Is ground into fine powder. When the patient takes the medicine for one time, the patient can take the medicine for one time. (Qianzheng san from Yang Jia cang Fang) 2, for infantile convulsions: bombyx Batryticatus and Scorpio, rhizoma Gastrodiae and radix Aconiti lateralis Preparata are mixed and processed. Is ground into fine powder. When the patient takes one word or half of money, fresh ginger is added to the medicine to adjust the temperature of water. (Ben Cao Yan Yi) 3, for children pinching mouth and sending out vomiting: two silkworm larva. Is powder. It is applied to the lips and mouths of children with honey. (Children's palace Qi Fang) 4, treating head wind: white muscardine silkworm (with silk and mouth removed), and rhizoma Alpiniae Officinarum. Is ground into fine powder. Half of money is taken every time, the white plum tea is adjusted and taken temporarily. (Baiyichongfang) 5, for acute laryngopathy complicated with swelling and pain: bombyx Batryticatus and rhizoma arisaematis, Bombyx Batryticatus and rhizoma arisaematis, and rhizoma arisaematis by baking, peeling, and filing. Is ground into fine powder. When the medicine is taken in a word, a little medicine powder is prepared from the natural juice of ginger, the medicine powder is thrown with boiled water and is quadden downwards, and the spitting of saliva and phlegm is fast and is taken occasionally. Contraindications are as follows: it is prohibited to take the medicine for yin deficiency with effulgent fire.

The invention is used for treating malignant lymphoma, and has the advantages of low cost, stable quality control, obvious treatment effect and high cure rate.

Detailed Description

The invention relates to a pharmaceutical composition for treating malignant lymphoma and application thereof, wherein the pharmaceutical composition is prepared from the following raw materials: astragalus root, rhizoma atractylodis macrocephalae, tuckahoe, American ginseng, radix bupleuri, radix curcumae, rhizoma cyperi, rhizoma sparganii, rhizoma zedoariae, bulbus fritilariae, pumice, selfheal, honeysuckle stem, platycodon grandiflorum, pseudo-ginseng, peach kernel, endothelium corneum gigeriae galli, turtle shell, cassia twig, scorpion, radix puerariae, radix salviae miltiorrhizae, centipede, earthworm and stiff silkworm.

In order to explain the present invention more clearly, the present invention will now be further described with reference to specific examples. Specific examples are as follows:

example one

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 32 parts of astragalus membranaceus, 5 parts of coked bighead atractylodes rhizome, 9 parts of poria cocos, 7 parts of American ginseng, 10 parts of radix bupleuri, 9 parts of radix curcumae, 5 parts of rhizoma cyperi, 11 parts of rhizoma sparganii, 11 parts of curcuma zedoary, 2 parts of bulbus fritilariae, 8 parts of bryozoatum, 13 parts of selfheal, 15 parts of honeysuckle stem, 11 parts of platycodon grandiflorum, 8 parts of pseudo-ginseng, 9 parts of peach kernel, 11 parts of endothelium corneum gigeriae galli, 20 parts of turtle shell, 9 parts of cassia twig, 7 parts of scorpion, 8 parts of radix puerariae, 13 parts of radix salviae milt.

Example two

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 8 parts of astragalus membranaceus, 11 parts of coked bighead atractylodes rhizome, 14 parts of poria cocos, 2 parts of American ginseng, 2 parts of radix bupleuri, 11 parts of radix curcumae, 9 parts of rhizoma cyperi, 6 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 9 parts of bulbus fritilariae, 14 parts of bryozoatum, 16 parts of selfheal, 8 parts of honeysuckle stem, 6 parts of platycodon grandiflorum, 10 parts of pseudo-ginseng, 11 parts of peach kernel, 5 parts of endothelium corneum gigeriae galli, 8 parts of turtle shell, 11 parts of cassia twig, 6 parts of scorpion, 14 parts of radix puerariae, 16 parts of radix salviae milt.

EXAMPLE III

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 9 parts of astragalus membranaceus, 6 parts of coked bighead atractylodes rhizome, 10 parts of poria cocos, 3 parts of American ginseng, 3 parts of radix bupleuri, 3 parts of radix curcumae, 6 parts of rhizoma cyperi, 5 parts of rhizoma sparganii, 6 parts of curcuma zedoary, 10 parts of bulbus fritilariae, 15 parts of pumice, 9 parts of selfheal, 9 parts of honeysuckle stem, 3 parts of platycodon grandiflorum, 9 parts of pseudo-ginseng, 5 parts of peach kernel, 3 parts of endothelium corneum gigeriae galli, 24 parts of turtle shell, 3 parts of cassia twig, 3 parts of scorpion, 9 parts of radix puerariae, 10 parts of radix salviae miltiorrhiza.

Example four

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 12 parts of coked bighead atractylodes rhizome, 15 parts of poria cocos, 6 parts of American ginseng, 10 parts of radix bupleuri, 10 parts of radix curcumae, 10 parts of rhizoma cyperi, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 3 parts of bulbus fritilariae, 9 parts of bryozoatum, 15 parts of selfheal, 30 parts of honeysuckle stem, 10 parts of platycodon grandiflorum, 10 parts of pseudo-ginseng, 10 parts of peach kernel, 10 parts of endothelium corneum gigeriae galli, 9 parts of turtle shell, 10 parts of cassia twig, 6 parts of scorpion, 15 parts of radix puerariae, 15 parts of radix salviae milt.

EXAMPLE five

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 19.5 parts of astragalus, 9 parts of scorched white atractylodes rhizome, 12.5 parts of tuckahoe, 4.5 parts of American ginseng, 6.5 parts of bupleurum, 6.5 parts of curcuma aromatica, 6.5 parts of nutgrass galingale rhizome, 7.5 parts of common burreed rhizome, 8 parts of zedoary, 6.5 parts of tendril-leaved fritillary bulb, 12 parts of bryozoatum, 112 parts of selfheal, 19.5 parts of honeysuckle stem, 6.5 parts of platycodon grandiflorum, 9.5 parts of pseudo-ginseng, 7.5 parts of peach kernel, 6.5 parts of chicken's gizzard-membrane, 16.5 parts of turtle shell, 6.5 parts of cassia twig, 4.5 parts of scorpion, 12 parts of kudzuvine root, 12.5 parts of salvia miltiorrhiza, 4 parts.

EXAMPLE six

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 9 parts of astragalus membranaceus, 6 parts of coked bighead atractylodes rhizome, 13 parts of poria cocos, 3 parts of American ginseng, 3 parts of radix bupleuri, 5 parts of radix curcumae, 6 parts of rhizoma cyperi, 7 parts of rhizoma sparganii, 8 parts of curcuma zedoary, 8 parts of bulbus fritilariae, 13 parts of pumice, 9 parts of selfheal, 21 parts of honeysuckle stem, 5 parts of platycodon grandiflorum, 9 parts of pseudo-ginseng, 10 parts of peach kernel, 3 parts of endothelium corneum gigeriae galli, 24 parts of turtle shell, 5 parts of cassia twig, 3 parts of scorpion, 9 parts of radix puerariae, 10 parts of radix salviae miltiorrhiza.

EXAMPLE seven

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 21 parts of astragalus membranaceus, 9 parts of coked bighead atractylodes rhizome, 15 parts of poria cocos, 6 parts of American ginseng, 7 parts of radix bupleuri, 10 parts of radix curcumae, 10 parts of rhizoma cyperi, 5 parts of rhizoma sparganii, 6 parts of curcuma zedoary, 10 parts of bulbus fritilariae, 15 parts of pumice, 13 parts of selfheal, 30 parts of honeysuckle stem, 10 parts of platycodon grandiflorum, 10 parts of pseudo-ginseng, 8 parts of peach kernel, 5 parts of endothelium corneum gigeriae galli, 16 parts of turtle shell, 10 parts of cassia twig, 6 parts of scorpion, 15 parts of radix puerariae, 12 parts of radix salviae miltiorrhiza.

Example eight

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 15 parts of astragalus, 7.5 parts of scorched atractylodes rhizome, 14 parts of tuckahoe, 4.5 parts of American ginseng, 5 parts of bupleurum, 7.5 parts of curcuma aromatica, 8 parts of nutgrass galingale rhizome, 6 parts of common burreed rhizome, 7 parts of zedoary, 9 parts of tendril-leaved fritillary bulb, 14 parts of bryozoatum, 11 parts of selfheal, 25.5 parts of honeysuckle stem, 7.5 parts of platycodon root, 9.5 parts of pseudo-ginseng, 9 parts of peach kernel, 4 parts of chicken's gizzard-membrane, 20 parts of turtle shell, 7.5 parts of cassia twig, 4.5 parts of scorpion, 12 parts of kudzuvine root, 11 parts of salvia miltiorrhiza, 4.

Example nine

Example ten

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 22 parts of astragalus membranaceus, 10 parts of coked bighead atractylodes rhizome, 10 parts of poria cocos, 3 parts of American ginseng, 8 parts of radix bupleuri, 3 parts of radix curcumae, 6 parts of rhizoma cyperi, 10 parts of rhizoma sparganii, 9 parts of curcuma zedoary, 7 parts of bulbus fritilariae, 9 parts of pumice, 14 parts of selfheal, 9 parts of honeysuckle stem, 3 parts of platycodon grandiflorum, 9 parts of pseudo-ginseng, 7 parts of peach kernel, 6 parts of endothelium corneum gigeriae galli, 15 parts of turtle shell, 3 parts of cassia twig, 3 parts of scorpion, 9 parts of radix puerariae, 15 parts of radix salviae miltiorrhiza.

EXAMPLE eleven

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 12 parts of coked bighead atractylodes rhizome, 12 parts of poria cocos, 6 parts of American ginseng, 10 parts of radix bupleuri, 5 parts of radix curcumae, 10 parts of rhizoma cyperi, 8 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 3 parts of bulbus fritilariae, 12 parts of pumice, 15 parts of selfheal, 20 parts of honeysuckle stem, 4 parts of platycodon grandiflorum, 10 parts of pseudo-ginseng, 5 parts of peach kernel, 10 parts of endothelium corneum gigeriae galli, 9 parts of turtle shell, 4 parts of cassia twig, 6 parts of scorpion, 15 parts of radix puerariae, 13 parts of radix salviae miltiorrhiza.

Example twelve

A pharmaceutical composition for treating malignant lymphoma is prepared from the following raw materials in parts by weight: 26 parts of astragalus, 11 parts of scorched atractylodes rhizome, 11 parts of tuckahoe, 4.5 parts of American ginseng, 9 parts of radix bupleuri, 4 parts of radix curcumae, 8 parts of rhizoma cyperi, 9 parts of rhizoma sparganii, 9.5 parts of curcuma zedoary, 5 parts of bulbus fritillariae cirrhosae, 10.5 parts of pumice, 14.5 parts of selfheal, 14.5 parts of honeysuckle stem, 3.5 parts of platycodon grandiflorum, 9.5 parts of pseudo-ginseng, 6 parts of peach kernel, 8 parts of endothelium corneum gigeriae galli, 12 parts of turtle shell, 3.5 parts of cassia twig, 4.5 parts of scorpion, 12 parts of radix puerariae, 14 parts of radix salviae miltiorrhizae, 4 parts.

EXAMPLE thirteen

Example fourteen

The above examples are merely illustrative for clearly illustrating the present invention and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art upon reference to the above description. It is not necessary or necessary to exhaustively enumerate all embodiments herein, and obvious variations or modifications can be made without departing from the scope of the invention as claimed.

Case 1: wangzhi, sex, male, age 54 years old, and people in Tubai county, Henan province, who have sudden low back pain and do not get out of bed in 2008 20 months, and then after 2 days of treatment in Tubai county central hospital, low fever (fluctuation of 37.5-38.7 ℃) appears, low fever in the morning and body temperature rises in the afternoon. The patients with hypodynamia and pale complexion are treated in hospital in China, China and county, and the treatment by transfusion is ineffective. The introduction of relatives shows that the treatment with the traditional Chinese medicine is still ineffective, and after the examination in Beijing Tongzhou Luhe hospital, the conventional abnormality of blood is found, so that the patient can puncture the bone marrow without further examination. Then, the patient is examined and treated in an affiliated hospital of Zhongshan university along with the child, and then the patient is subjected to bone puncture and biopsy and whole body PET-CT examination in 26-30 days at 9 months in 2008; 1. the high metabolic focus on the left humeral head and the left sacral 4 vertebral body considers that the possibility of lymphoma is high; 2. spleen enlargement and mild metabolism; 3. the metabolism of the bone marrow at the proximal ends of the central axis bone, the pelvis bone and the long bones of the limbs is slightly active; 4. the above changes, pseudo lymphoma and reactivity changes are identified, and patients still have repeated fever and hypodynamia after being discharged after pretty anti-infection treatment, erythrocyte suspension infusion, albumin supplement and other treatments. The first hospital was attached to Zhongshan university for many times in 2008 to examine and treat. And (3) pathological prompting after the biopsy operation: tumor cell infiltration is seen in bone marrow tissues, B cell lymphoma is considered, 10 times of chemotherapy treatment is given, the effect is poor, and for further treatment in our hospital, the clinic catches our family with 'non-Hodgkin lymphoma', and auxiliary examination is carried out: blood routine: WBC 5.14X 10⁹/L RBC：4.02×10¹²/L HGB：131g/L PLT:106×10⁹Absolute value of reticulocytes: 106.2 × 10⁹Percentage of reticulocytes/L: 2.78% CRP<10 mg/L. According to the symptoms of the patient, the general lymphadenectasis, splenomegaly, hypochondrium distention, oppression, hypodynamia, anorexia, emesis, short breath, spontaneous perspiration, dysphoria with feverish sensation in chest, low fever, dark tongue, ecchymosis under tongue, wiry, unsmooth and rapid pulse. The diagnosis after syndrome differentiation is as follows: a malignant nucleus. Traditional Chinese medicine typing: phlegm and blood stasis, viscera deficiency, liver depression and phlegm coagulation, qi and blood deficiency: break blood and eliminate mass, reduce phlegm and eliminate stagnation, regulate viscera, sooth liver and relieve depression, and tonify qi and nourish blood. By adopting the eighth embodiment of the invention, the usage is as follows: the traditional Chinese medicine is taken one dose per dayThe decoction is decocted with water for three times to obtain about 840ml of juice, and the juice is divided into three times for administration in the morning, at noon and evening. After the patient takes the medicine for three days, the symptoms are improved, the food intake is increased, after the patient takes the medicine for one week, the symptoms are obviously improved, and after the patient insists on the treatment for half a year in a hospital, the patient reviews the PET-CT results to show that: all indexes are normal, all indexes such as blood routine and the like are normal, and the disease does not relapse after being periodically reviewed after discharge.

Case 2: chen is certain, sex is female, age is 50 years old, patients in China, Tubai county, Henan province have no obvious inducement to intermittence to cause epigastric pain at the beginning of 2007 6 months, can be relieved in about one minute, have no nausea and vomiting, do not influence diet, and have poor medication effect when being diagnosed as gastritis in local outpatient service in Hainan. After one week, the patient with abdominal pain is diagnosed in the hospital of the provinces of Hainan province and diagnosed as appendicitis by excision, suspected lymphoma is pathologically checked, the patient is completely examined in the hematology department, the patient is diagnosed as non-Hodgkin lymphoma, the patient is applied with rituximab injection (rituximab) for chemotherapy for 8 courses of treatment, and the patient is discharged from the hospital after improvement. Relapse is found in the physical examination in 7 months in 2008, and the patient is discharged after being hospitalized and chemo-treated again for 6 courses of treatment. The patient is diagnosed in the first subsidiary hospital of Zhengzhou university in 2009 for 3 months to recheck and relapse again, and is subjected to hospitalization and chemotherapy for 6 courses (the specific treatment is not detailed) and then is discharged. In 2010, 2 months, hematochezia appears, and the patient is diagnosed in a third people hospital in Tongbai county on 16 days in 3 months, and then the patient is subjected to enteroscopy to diagnose the rectal space occupation, wherein the pathological examination suggestion: "lymphoproliferative lesions" consider non-hodgkin lymphomas. The diagnosis was made at the first affiliated hospital of zhengzhou university at 9/4/2010, and the diagnosis was "non-hodgkin lymphoma-diffuse large B-cell lymphoma IV stage" (tonsil invasion, left cervical IV area, mediastinum, left axillary, supraseptal, abdominal cavity, retroperitoneal, pelvic cavity, bilateral iliac paravascular, right intersubular lymph node, mid-rectal segment, spleen) aaipii score of 2 points, high school risk, examination by 2010-08-21 enteroscopy shows: rectal space occupation. 2010-08-22 neck color ultrasonography: multiple lymph node echoes of the left neck, the larger one of which is approximately 21mm by 7mm in size. To come to my hospital for further treatment. The clinic collected my family as "non-hodgkin lymphoma-diffuse large B cell lymphoma stage IV", laboratory examination: WBC: 3.50X 10⁹/L RBC：3.40×10¹²/L HGB：106g/L PLT:104×10⁹absolute/L reticulocyteThe value: 140.4X 10⁹Percentage of reticulocytes/L: 4.13% CRP: 32.34mg/L, depending on patient symptoms: general lymphadenectasis, splenomegaly, dark and gloomy complexion, hypochondriac distending pain, debilitation, short breath, asthma, spontaneous perspiration, five-heart fever, low fever, intestinal tract tumor, and hematochezia. A dark tongue with a thin and white coating and a wiry, astringent, thready and weak pulse. The diagnosis after syndrome differentiation is as follows: a malignant nucleus. Traditional Chinese medicine typing: phlegm and blood stasis, viscera deficiency, liver stagnation and phlegm coagulation, and qi and blood deficiency; the therapeutic principle of traditional Chinese medicine is as follows: break blood and eliminate mass, reduce phlegm and eliminate stagnation, regulate viscera, sooth liver and relieve depression, and tonify qi and nourish blood. By adopting the tenth embodiment of the invention, the usage is that the traditional Chinese medicine is taken one dose per day, decocted with water for three times, and the decoction is taken about 840m1 for three times in the morning, at noon and at night. The symptoms of the patients are relieved one week after the patients take the medicine, the symptoms basically disappear after three months of continuous treatment, the patients do not relapse until now, and the results of the reexamination of PET-CT of the patients in the first subsidiary hospital of Zhengzhou university are normal after one year.

Case 3: range, sex: male, age: in 16 years old, patients who are filial sensate in Hubei have no obvious induction and lumbosacral pain accompanied with double lower limb radiation pain in 2011, and the patients are treated in local hospitals according to the following formula: the lumbar disc herniation gives physiotherapy to half a month, pain is not relieved and is in an aggravation trend, related examination is perfected by transferring to a coordination hospital in Wuhan City, and bone tumor is suspected and is not treated; transferring to Beijing 301 hospital and other hospitals in 2012 for 2 months without diagnosis, transferring to Beijing Oldham hospital for 3 months and 13 days in 2012 for pelvic cavity aspiration biopsy in Beijing Onghuijin Hotan hospital for diagnosis as "non-Hodgkin lymphoma", transferring to Beijing tumor hospital for treatment, and diagnosing as: non-hodgkin lymphoma stage IV, stage B enlarged cell types (invasion of L5, sacrum, right ilium; invasion of the supraclavicular, diaphragmatic, splenomental, retroperitoneal, periiliac lymph nodes; invasion of the left lung; invasion of the spleen), administration of CHOPE regimen chemotherapy for four cycles, with poor efficacy and intolerable lumbosacral pain, outpatient admission of "non-hodgkin lymphoma" to my hospital for further treatment, based on patient's primary symptoms: swollen lymph nodes, pain in the lumbosacral region, depression, asthenia, anorexia, short breath, spontaneous perspiration, pale tongue, ecchymosis under tongue, wiry, unsmooth and rapid pulse. The diagnosis after syndrome differentiation is as follows: a malignant nucleus. Traditional Chinese medicine typing: phlegm and blood stasis, viscera deficiency, liver depression and phlegm coagulation, qi and blood deficiency: break blood and eliminate mass, reduce phlegm and eliminate stagnation, regulate viscera, sooth liver and relieve depression, and tonify qi and nourish blood. By adopting the thirteen embodiment of the invention, the patient's condition improves after taking the medicine for one week, the patient's condition basically recovers after insisting on taking the medicine for half a year, and the patient rechecks the MR results at Tongji medical college of Huazhong university of science and technology one year later shows that: no obvious abnormality is found, and all patients are normal in the follow-up process at the later stage and are cured at present.

The present invention is further described below in connection with clinical trials conducted in my hospital, namely the Zhenyu blood disease Hospital in Deng, Henan:

1. case selection: the selected cases are all patients with malignant lymphoma in our hospital, 37 Hodgkin lymphoma patients, 29 male patients and 8 female patients are selected, and the course of disease is 30 days to 10 months; 158 non-hodgkin lymphoma patients.

2. Diagnostic criteria: according to the national administration of traditional Chinese medicine, the standard of curative effect of traditional Chinese medicine diagnosis, the patient's condition and the PET/CT clinical manifestations.

3. The treatment method comprises the following steps: the medicine is taken according to the taking method of the invention every day, one dose is taken every day, the decoction is taken for three times, about 840ml of juice is taken, and the medicine is taken for three times in the morning, at noon and at night. One month is a course of treatment, rest for 4 days, and take 3 courses continuously until the clinical symptoms disappear, and consolidate three courses. And was followed up for 3 months.

4. The evaluation standard of the curative effect is as follows:

(1) basically curing: the tumor disappears for more than 5 years completely; the clinical symptoms completely disappear, the PET/CT examination result is normal, and no relapse occurs after 5 years of follow-up.

(2) And (3) relieving: the tumor is reduced by more than 80 percent, the clinical symptoms basically disappear, and the disease is stable and does not relapse after the follow-up visit for 3 years.

(3) The obvious progress is as follows: the tumor is reduced by more than 50 percent, other focuses are not increased, the disease is maintained for more than 3 years, the clinical symptoms basically disappear, and the follow-up disease is stable for 3 years and does not relapse.

(4) And (4) invalidation: after six courses of treatment, the tumor is not obviously changed, and the clinical symptoms are that the PET/CT examination result is not obviously changed.

5. The treatment effect is as follows: the invention is applied to 195 clinical malignant lymphoma patients for 3 courses of treatment until clinical symptom signs disappear, and after a PET/CT inspection result is normal, the curative effect is consolidated, the three courses of treatment are taken, and the curative effect evaluation standard is applied to evaluate the curative effect: 126 cases of basic cure are about 64.6%, 48 cases of remission are about 24.6%, 15 cases of obvious progress are about 7.6%, 6 cases of no effect are about 3%, and the total effective rate is about 96.9%.

Claims

1. A pharmaceutical composition for treating malignant lymphoma, comprising: the pharmaceutical composition is prepared from the following raw materials: astragalus root, rhizoma atractylodis macrocephalae, tuckahoe, American ginseng, radix bupleuri, radix curcumae, rhizoma cyperi, rhizoma sparganii, rhizoma zedoariae, bulbus fritilariae, pumice, selfheal, honeysuckle stem, platycodon grandiflorum, pseudo-ginseng, peach kernel, endothelium corneum gigeriae galli, turtle shell, cassia twig, scorpion, radix puerariae, radix salviae miltiorrhizae, centipede, earthworm and stiff silkworm.

2. The pharmaceutical composition for treating malignant lymphoma according to claim 1, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 9-30 parts of astragalus membranaceus, 6-12 parts of coked bighead atractylodes rhizome, 10-15 parts of poria cocos, 3-6 parts of American ginseng, 3-10 parts of radix bupleuri, 3-10 parts of radix curcumae, 6-10 parts of rhizoma cyperi, 5-10 parts of rhizoma sparganii, 6-10 parts of curcuma zedoary, 3-10 parts of bulbus fritilariae, 9-15 parts of bryozoatum, 9-15 parts of selfheal, 9-30 parts of honeysuckle stem, 3-10 parts of platycodon grandiflorum, 9-10 parts of pseudo-ginseng, 5-10 parts of peach kernel, 3-10 parts of endothelium corneum gigeriae galli, 9-24 parts of turtle shell, 3-10 parts of cassia twig, 3-6 parts of scorpion, 9-15 parts of radix puerariae, 10-15 parts of salvia miltiorrhiza, 3-5 parts of centipede.

3. The pharmaceutical composition for treating malignant lymphoma according to claim 1, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 9-21 parts of astragalus membranaceus, 6-9 parts of coked bighead atractylodes rhizome, 13-15 parts of poria cocos, 3-6 parts of American ginseng, 3-7 parts of radix bupleuri, 5-10 parts of radix curcumae, 6-10 parts of rhizoma cyperi, 5-7 parts of rhizoma sparganii, 6-8 parts of curcuma zedoary, 8-10 parts of bulbus fritilariae, 13-15 parts of bryozoatum, 9-13 parts of selfheal, 21-30 parts of honeysuckle stem, 5-10 parts of platycodon grandiflorum, 9-10 parts of pseudo-ginseng, 8-10 parts of peach kernel, 3-5 parts of endothelium corneum gigeriae galli, 16-24 parts of turtle shell, 5-10 parts of cassia twig, 3-6 parts of scorpion, 9-15 parts of radix puerariae, 10-12 parts of salvia miltiorrhiza, 3-5 parts of centipede.

4. The pharmaceutical composition for treating malignant lymphoma according to claim 1, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 7 parts of coked bighead atractylodes rhizome, 14 parts of poria cocos, 6 parts of American ginseng, 7 parts of radix bupleuri, 9 parts of radix curcumae, 9 parts of rhizoma cyperi, 5 parts of rhizoma sparganii, 6 parts of curcuma zedoary, 10 parts of bulbus fritilariae, 15 parts of pumice, 9 parts of selfheal, 30 parts of honeysuckle stem, 5 parts of platycodon grandiflorum, 10 parts of pseudo-ginseng, 10 parts of peach kernel, 4 parts of endothelium corneum gigeriae galli, 20 parts of turtle shell, 5 parts of cassia twig, 6 parts of scorpion, 14 parts of radix puerariae, 10 parts of radix salviae miltiorrhiza.

5. The pharmaceutical composition for treating malignant lymphoma according to claim 1, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 22-30 parts of astragalus membranaceus, 10-12 parts of coked bighead atractylodes rhizome, 10-12 parts of poria cocos, 3-6 parts of American ginseng, 8-10 parts of radix bupleuri, 3-5 parts of radix curcumae, 6-10 parts of rhizoma cyperi, 8-10 parts of rhizoma sparganii, 9-10 parts of curcuma zedoary, 3-7 parts of bulbus fritilariae, 9-12 parts of pumice, 14-15 parts of selfheal, 9-20 parts of honeysuckle stem, 3-4 parts of platycodon grandiflorum, 9-10 parts of pseudo-ginseng, 5-7 parts of peach kernel, 6-10 parts of endothelium corneum gigeriae galli, 9-15 parts of turtle shell, 3-4 parts of cassia twig, 3-6 parts of scorpion, 9-15 parts of radix puerariae, 13-15 parts of salvia miltiorrhiza, 3-5 parts of centipede.

6. The pharmaceutical composition for treating malignant lymphoma according to claim 5, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 28 parts of astragalus membranaceus, 10 parts of coked bighead atractylodes rhizome, 11 parts of poria cocos, 4 parts of American ginseng, 8 parts of radix bupleuri, 5 parts of radix curcumae, 7 parts of rhizoma cyperi, 9 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 6 parts of bulbus fritilariae, 11 parts of bryozoatum, 14 parts of selfheal, 15 parts of honeysuckle stem, 3 parts of platycodon grandiflorum, 10 parts of pseudo-ginseng, 6 parts of peach kernel, 9 parts of endothelium corneum gigeriae galli, 13 parts of turtle shell, 4 parts of cassia twig, 5 parts of scorpion, 14 parts of radix puerariae, 13 parts of radix salviae milt.

7. The pharmaceutical composition for treating malignant lymphoma according to claim 1, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 25 parts of astragalus membranaceus, 10 parts of coked bighead atractylodes rhizome, 13 parts of poria cocos, 6 parts of American ginseng, 10 parts of radix bupleuri, 10 parts of radix curcumae, 10 parts of rhizoma cyperi, 9 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 9 parts of bulbus fritilariae, 14 parts of pumice, 15 parts of selfheal, 30 parts of honeysuckle stem, 10 parts of platycodon grandiflorum, 9 parts of pseudo-ginseng, 9 parts of peach kernel, 10 parts of endothelium corneum gigeriae galli, 23 parts of turtle shell, 10 parts of cassia twig, 6 parts of scorpion, 15 parts of radix puerariae, 13 parts of radix salviae miltiorrhiza.

8. Use of a pharmaceutical composition according to any one of claims 1 to 7 for the preparation of a pharmaceutical composition for the treatment of malignant lymphoma.