CN112513038B - 抑制creb结合蛋白(cbp) - Google Patents

抑制creb结合蛋白(cbp) Download PDF

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Publication number
CN112513038B
CN112513038B CN201980050022.XA CN201980050022A CN112513038B CN 112513038 B CN112513038 B CN 112513038B CN 201980050022 A CN201980050022 A CN 201980050022A CN 112513038 B CN112513038 B CN 112513038B
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alkyl
methyl
compound
cycloalkyl
aryl
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CN112513038A (zh
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S·E·R·席勒
托尔斯滕·赫伯茨
H·李
B·格瑞夫斯
S·米什克
A·V·韦斯特
A·爱立信
J·R·唐宁
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980050022.XA 2018-06-29 2019-06-28 抑制creb结合蛋白(cbp) Active CN112513038B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211658329.8A CN116178369A (zh) 2018-06-29 2019-06-28 抑制creb结合蛋白(cbp)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862692593P 2018-06-29 2018-06-29
US62/692,593 2018-06-29
USPCT/US2018/051214 2018-09-14
PCT/US2018/051214 WO2019055869A1 (en) 2017-09-15 2018-09-14 TETRAHYDROIMIDAZO QUINOLINE COMPOSITIONS AS INHIBITORS OF CBP / P300
USPCT/US2018/051235 2018-09-14
PCT/US2018/051235 WO2019055877A1 (en) 2017-09-15 2018-09-14 TETRAHYDROIMIDAZO QUINOLINE COMPOSITIONS AS INHIBITORS OF CBP / P300
US201962819490P 2019-03-15 2019-03-15
US62/819,490 2019-03-15
PCT/US2019/039936 WO2020006483A1 (en) 2018-06-29 2019-06-28 Inhibiting creb binding protein (cbp)

Related Child Applications (1)

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CN202211658329.8A Division CN116178369A (zh) 2018-06-29 2019-06-28 抑制creb结合蛋白(cbp)

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CN112513038A CN112513038A (zh) 2021-03-16
CN112513038B true CN112513038B (zh) 2023-01-10

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CN202211658329.8A Pending CN116178369A (zh) 2018-06-29 2019-06-28 抑制creb结合蛋白(cbp)

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MX2023013508A (es) * 2018-06-29 2023-12-13 Forma Therapeutics Inc Inhibicion de la proteina de union a creb (cbp).
CN113784967B (zh) * 2019-03-15 2024-07-26 福马治疗股份有限公司 用于治疗雄激素受体阳性形式的癌症的组合物和方法
TW202102494A (zh) 2019-03-15 2021-01-16 美商弗瑪治療公司 抑制環amp-反應元件-結合蛋白(creb)
KR20230028512A (ko) 2020-06-25 2023-02-28 톨레모 테라퓨틱스 아게 EGFR-돌연변이 NSCLC의 치료에 사용하기 위한 CBP/p300 브로모도메인 억제제 및 EGFR 억제제의 조합물
KR20230028798A (ko) 2020-06-25 2023-03-02 톨레모 테라퓨틱스 아게 암 치료를 위한 CBP/p300 브로모도메인 억제제 및 KRAS 억제제의 조합물
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers
US11795168B2 (en) * 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)

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KR20250067962A (ko) 2025-05-15
US20220162207A1 (en) 2022-05-26
IL279734B2 (en) 2024-11-01
US20200299295A1 (en) 2020-09-24
CA3105099A1 (en) 2020-01-02
MA50675A (fr) 2021-04-07
KR20210025631A (ko) 2021-03-09
SG11202012767UA (en) 2021-01-28
MA50675B1 (fr) 2021-09-30
IL313466A (en) 2024-08-01
JP2025094157A (ja) 2025-06-24
PL3587418T3 (pl) 2022-02-21
IL279734A (en) 2021-03-01
ZA202100509B (en) 2022-12-21
EP3998266A1 (en) 2022-05-18
JP6781806B2 (ja) 2020-11-04
KR102805503B1 (ko) 2025-05-09
AU2025210762A1 (en) 2025-08-21
LT3587418T (lt) 2021-11-25
AU2019295790B2 (en) 2023-07-13
US10870648B2 (en) 2020-12-22
MX2023013508A (es) 2023-12-13
US11254674B2 (en) 2022-02-22
IL313466B1 (en) 2025-07-01
SA520420909B1 (ar) 2024-11-12
PT3587418T (pt) 2021-12-02
JP2020002135A (ja) 2020-01-09
JP7017801B2 (ja) 2022-02-09
IL279734B1 (en) 2024-07-01
WO2020006483A1 (en) 2020-01-02
AU2019295790A1 (en) 2021-01-28
AU2023226653A1 (en) 2023-09-21
HRP20211698T1 (hr) 2022-02-18
CN112513038A (zh) 2021-03-16
US12378242B2 (en) 2025-08-05
US20200002332A1 (en) 2020-01-02
RS62732B1 (sr) 2022-01-31
CN116178369A (zh) 2023-05-30
SI3587418T1 (sl) 2022-03-31
IL313466B2 (en) 2025-11-01
IL321337A (en) 2025-08-01
JP2021042255A (ja) 2021-03-18
AU2023226653B2 (en) 2025-09-04
CY1124762T1 (el) 2022-07-22
HUE056885T2 (hu) 2022-03-28
ES2900105T3 (es) 2022-03-15
DK3587418T3 (da) 2021-10-11
BR112020026783A2 (pt) 2021-03-30
JP2020128426A (ja) 2020-08-27
MX2020014303A (es) 2021-03-25
SMT202100636T1 (it) 2022-01-10

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