CN112494527A

CN112494527A - Formula for preventing and treating hyperuricemia and gout and application thereof

Info

Publication number: CN112494527A
Application number: CN202011548561.7A
Authority: CN
Inventors: 石丽香; 武少锋; 银雅; 贾旭荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-12-24
Filing date: 2020-12-24
Publication date: 2021-03-16

Abstract

The invention discloses a formula for preventing and treating hyperuricemia and gout and application thereof, belonging to the field of health care products. The formula comprises the following components in parts by weight: 10-50 parts of carrot and 1-10 parts of honey. The invention adopts proper amount of carrot and honey as a formula to treat patients with hyperuricemia and gout, and the formula obviously reduces the uric acid content of the patients and obviously improves the gout symptoms. The formula provided by the invention has the advantages of low cost, obvious effect and no side effect.

Description

Formula for preventing and treating hyperuricemia and gout and application thereof

Technical Field

The invention belongs to the field of health care products, and particularly relates to a formula for preventing and treating hyperuricemia and gout and application thereof.

Background

Uric acid is the final metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia. Under normal purine diet, the level of fasting uric acid is higher than 416 mu mol/L in male and higher than 360 mu mo1/L in female, namely hyperuricemia (hyperuricemia). Generally, there is no subjective symptom when the patient is in a hyperuricemia symptom state, but if the patient is in the hyperuricemia symptom state for a long time, urate in blood is crystallized and deposited on joints, subcutaneous tissues, kidneys and other parts, and a series of clinical manifestations such as gout and gout complications occur.

Nowadays, gout becomes the second major metabolic disease of China, which is second only to diabetes, and seriously harms the life and health of people. At present, when treating hyperuricemia, gout caused by hyperuricemia and gout complications, uric acid in blood needs to be controlled: drugs for promoting uric acid excretion such as benzydarone and resilenide are suitable for patients with uric acid excretion (90%); the medicine (mainly comprising a xanthine oxidase inhibitor) for inhibiting uric acid production is suitable for patients with hyperuricemia, such as allopurinol and febuxostat. However, as the clinical application of these drugs increases, adverse reactions are gradually exposed.

Benzbromarone is mainly used for reducing the concentration of uric acid in blood by inhibiting reabsorption of uric acid by renal tubules, is first marketed in France in the 70 th century, is withdrawn from the market in some countries after the drug is reported to cause serious hepatotoxicity internationally in 2003, and is currently used in Germany and some Asian countries such as Japan, Singapore and China. In 2013 in 2004, 533 cases of adverse reaction event reports of the benzene australon were received in the national adverse reaction detection database of drugs, and the adverse reaction event reports mainly comprise gastrointestinal tract system damage, skin and accessory damage thereof, systemic damage, liver and gall system damage, urinary system damage and the like.

Rasiland, approved in the united states at 12 months 2015, is an orally effective urate anion transporter-1 (URAT 1) inhibitor, which reduces uric acid absorption by inhibiting the action of URAT1, but is susceptible to acute renal failure when used alone, and therefore is often used in combination with xanthine oxidase inhibitors, with adverse effects including acute renal injury, hepatotoxicity, cardiotoxicity, lethargy, etc.

The drugs have large toxic and side effects under the conventional dosage, and the tolerance of the drugs is generally low, so that the clinical application of the drugs is limited to a certain extent.

Disclosure of Invention

In order to solve the technical problems, the invention provides a formula for preventing and treating hyperuricemia and gout and application thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

a formula for preventing and treating hyperuricemia and gout comprises carrot and honey.

Further, the formula comprises the following components in parts by weight: 10-50 parts of carrot and 1-10 parts of honey.

Furthermore, the formula comprises the following components in parts by weight: 15-40 parts of carrot and 2-8 parts of honey.

Furthermore, the formula comprises the following components in parts by weight: 20-30 parts of carrot and 4-6 parts of honey.

The invention also provides application of the formula in preparation of medicines for preventing and treating hyperuricemia and gout.

Carrots are well known to treat anemia, cold, constipation and hypertension, prevent cancer, invigorate stomach and beautify skin, and carrots are rich in vitamins and minerals such as carotene, vitamin B1, vitamin B2, calcium, iron, phosphorus and the like. Since vitamin B2 and folic acid in carrot have anticancer effect, and can enhance the anticancer capability of human body after being eaten frequently, the carrot is called "vegetable for preventing cancer". One study by american scientists shows that lung cancer can be prevented by eating carrot often.

The carrot also contains an enzyme capable of decomposing vitamin C, namely vitamin C oxidase, so that the nutritive value of the white radish is greatly reduced when the carrot and the white radish rich in vitamin C are eaten together. However, vitamin C can be protected from destruction by adding a small amount of vinegar when cooking carrot and white radish. The vinegar-mixed shredded radish which is often eaten by Japanese in the years is a side dish with reasonable collocation and rich nutrition.

The specific efficacy of carrots is as follows:

(1) benefiting liver and improving vision:

the carrot contains a large amount of carotene, the molecular structure of the carotene is equivalent to 2 molecules of vitamin A, after entering a body, the carotene passes through the action of enzyme in the liver and small intestine mucosa, 50 percent of the carotene is changed into the vitamin A, and the carotene has the effects of tonifying liver and improving eyesight and can treat nyctalopia.

(2) Benefiting diaphragm and widening intestine:

the carrot contains plant fiber, has strong water absorption, is easy to expand in volume in the intestinal tract, is an 'filling substance' in the intestinal tract, and can strengthen the peristalsis of the intestinal tract, thereby benefiting diaphragm, widening intestine, relaxing bowels and preventing cancer.

(3) Invigorating spleen and removing malnutrition:

vitamin A is an essential substance for normal growth and development of bones, is beneficial to cell proliferation and growth, is an essential element for body growth, and has important significance for promoting the growth and development of infants.

(4) Enhancing the immune function:

the carotene is converted into vitamin A, which is helpful for enhancing the immunity of the body and has important function in the process of preventing epithelial cell canceration. The lignin in carrot can also improve the immune mechanism of the organism and indirectly kill cancer cells.

(5) Reducing blood sugar and blood fat:

the carrot also contains substances for reducing blood sugar, is a good food for patients with diabetes, contains certain components such as quercetin and kaempferol, can increase coronary blood flow, reduce blood fat, promote epinephrine synthesis, and has the functions of reducing blood pressure and strengthening heart, so that the carrot is a good food therapy product for patients with hypertension and coronary heart disease.

(6) Preventing hands and feet from peeling:

vitamin A belongs to fat-soluble vitamins, has protective effect on the surface layer of skin, and if the vitamin A is lacked, the phenomena of skin dryness, desquamation and the like can be caused, and more foods rich in vitamin A, such as carrots and the like can be eaten.

Care when eating carrots:

(1) it is not suitable for eating radix Raphani which is cut into pieces and washed with water or soaked in water for a long time.

(2) It is not suitable for taking dihydrocodeine with urine.

The honey is a natural sweet substance which is obtained by fully brewing the nectar collected from the flowers of the flowering plants by bees in a honeycomb, and has fragrant and rich smell and pure, sweet and delicious taste.

The honey is prepared by collecting nectar or secretion with water content of 75% from flower of plant, storing in the second stomach, storing the nectar or secretion in nest hole by worker bee under the action of several kinds of conversion in bee body, sealing with beeswax, repeating around 15 days for brewing to enrich vitamins, minerals and amino acids to certain value, and converting polysaccharide in nectar into monosaccharide glucose and fructose capable of being absorbed directly by human body, and the nectar or secretion with water content less than 23% is honey.

Honey is supersaturated sugar solution, and can generate crystallization at low temperature, wherein the generated crystallization is glucose, and the part without crystallization is mainly fructose.

The honey has effects of clearing heat, invigorating spleen, moistening dryness, relieving pain, removing toxic substance, reducing weight, and whitening skin.

Honey is sweet and mild, and is nontoxic. Biyu (bibliographic) says that the temperature is very low.

B, B: all honey smells are mainly flowers. In winter and summer, in autumn and spring, it is apt to become sour. Min and Guang-Mi are extremely hot, and in the south, there are little frost and snow, and many flowers are hot. Sichuan honey is warm, while xi honey is cool .

Liu Wang element is recorded as follows: the honey is formed in bees, and the bees are cold and warm, and have the same nature and different properties.

The time is rare and is recorded as: honey is cool, cooked, warm, not cold but not dry, and can neutralize qi, so it is not suitable for diseases of twelve zang-fu organs, deceive. But if it is eaten too much, damp-heat worms will be produced, especially for children. Wang is charged with Lung Heng from Yun to Feng based on the natural fire and the pathogenic fire and toxin at the tail. Honey is bee liquid, and is poisonous if eaten too much, and is unknown. It is nontoxic after refining.

B, reproducing: although honey is non-toxic, it can also produce wind if it is eaten too much.

Zhuzhenheng is recorded: honey prefers to enter the spleen. Northwest is highly dry and beneficial to the people who eat it. Southeast Asia is wet and harmful to spleen if eaten too much.

Thought far away says: do not eat raw honey for July and cause cholera suddenly. Those with bluish-green, red and sour taste are restless. It should not be eaten with scallion and lettuce.

Mainly treats heart and abdomen pathogenic qi, fright epilepsy, five viscera insufficiency, qi tonifying, middle energizer tonifying, pain relieving, detoxifying, diseases removing and various medicines. It can strengthen the mind and lighten the body, avoid hunger and aging and prolong life after long-term administration (Benjing). Nourishing spleen qi, relieving restlessness, stopping diarrhea, relieving intestinal pain, relieving pain in muscles and joints, treating aphtha, and improving eyesight and hearing (bibliography). Malnutrition of the teeth, aphtha of the lips, red eyes and skin, and parasites (reservoir). For sudden cardiac pain and red and white dysentery, take the decoction as honey syrup and stop with a bowl; or mixing ginger juice with honey, water and taking the mixture immediately. Take the medicine regularly, such as Huahong (coconut right). For heart and abdomen blood stabbing pain and red and white dysentery, it is taken with Sheng Di Huang juice one spoon each, just need to be removed. Smash Bulbus Allii Macrostemi, apply decoction fire, and regulate spleen and stomach (Shizhen).

The medicine has five functions: clearing heat, tonifying middle energizer, removing toxicity, moistening dryness, and alleviating pain. The nature is cool when it is used, so it can clear heat; when cooked, it can tonify middle energizer because it is warm in nature. Sweet and neutral, so it can remove toxicity; it is soft and moist, so it can moisten dryness. Relieve the pain of heart, abdomen, muscles and sores and ulcers; harmonizing and harmonizing the middle energizer can harmonize the various herbs, and it has the same action as gan Cao. Zhang Zhongjing for yangming with constipation, and Mi Jiang dao Fang, Cheng Qian Gu Shen Fang.

Washing, namely: but if people feel hot and the limbs are not harmonized, the syrup is taken in a bowl, which is very good. The eyes are also pointed at the heat membrane, and domestic white honey is used as the top, wood honey is the second, and cliff honey is the second. It is decocted with ginger juice to make the treatment effect on pellagra.

The cautions of honey during eating:

(1) honey naturally containing active enzyme cannot be heated to above 60 ℃, otherwise the active enzyme is denatured and inactivated at high temperature, and nutritional ingredients in the honey are damaged. The honey has sweet taste when being brewed with warm water or cold water, and the taste can be changed into sour when being brewed with higher temperature.

(2) The infant less than one year old is not suitable for eating honey, the honey is easily polluted by the clostridium botulinum in the brewing, transporting and storing processes, the infant can breed in the intestinal tract and generate toxin after eating the lactobacillus botulinum due to weak resistance, and the detoxifying function of the liver is poor, so the infant is easily subjected to the clostridium botulinum food poisoning.

Infants poisoned by honey can suffer from tardive paralysis, weak crying, weak milk absorption and dyspnea. Infants younger than 6 months are more susceptible to this disease. The poisoning symptoms usually occur 8-36 hours after the honey or honey-containing food is eaten, and the symptoms usually comprise constipation, fatigue and anorexia.

Although infants have a small probability of developing a botulinum infection, physicians have suggested: before the child is full of 1 year old, he is not given honey and its products.

(3) It is not suitable for people with abdominal distention and thick and greasy tongue coating due to damp obstruction of middle energizer.

Compared with the prior art, the invention has the following beneficial effects:

the invention adopts proper amount of carrot and honey as a formula to treat patients with hyperuricemia and gout, and the formula obviously reduces the uric acid content of the patients and obviously improves the gout symptoms. The formula provided by the invention has the advantages of low cost, obvious effect and no side effect.

Drawings

FIG. 1 shows the results of examination No. 9/23 of patient in example 1.

FIG. 2 shows the results of examination of example 1 on patient No. 10/20.

Detailed Description

Example 1

The embodiment provides a formula for preventing and treating hyperuricemia and gout, which comprises the following components in parts by weight: 30 parts of carrot and 6 parts of honey.

The examination results of the patients, namely, the patients of 55 years old and No. 9/23 in 2020 are shown in figure 1, and the uric acid is up to 442 mu mol/L, and the examination is carried out again in No. 10/20 after the patients take the formula provided by the embodiment, and the results are shown in figure 2, wherein the uric acid in figure 2 is 374 mu mol/L. By taking the formula in the embodiment, the uric acid level is greatly reduced, and the effect is obvious.

Example 2

1. Case selection

100 uric acid patients were randomly divided into two groups, a treatment group and a control group. The treatment group comprises 50 cases, 30 cases of men and 20 cases of women, the age is 40-60 years, the average age is 51.5 years, the course is 3-5 years, and the average course is 4.82 years; the control group comprises 50 cases, 35 cases for men and 15 cases for women, the age is 40-60 years, the average age is 52.3 years, the course is 3-5 years, and the average course is 4.79 years.

2. Mode of administration

Treatment groups: the formula in example 1 is taken 2 times a day, 100 g each time, and 2 months after meals.

Control group: febuxostat tablets were orally administered according to the instructions for 2 months.

3. Diagnostic criteria

And (3) healing: the clinical symptoms completely disappear, and the uric acid is lower than 416 mu mol/L.

The effect is shown: the clinical symptoms substantially disappeared.

The method has the following advantages: the clinical symptoms are reduced.

And (4) invalidation: there is essentially no change.

4. Symptoms and signs

Hyperuricemia refers to the condition that the uric acid level of a patient exceeds 416 mu mol/L, and generally has no obvious symptoms. If the uric acid of a patient is in a high level for a long time, the patient can be possibly suffered from joint diseases, namely gout, swelling, pain and deformity of finger joints and toe joints.

5. Test results

The results of comparing the therapeutic effects of the treatment group and the control group are shown in table 1:

TABLE 1

	Number of examples	Cure of disease	Show effect	Is effective	Invalidation	Cure rate	High efficiency
								Treatment group	50	31	5	14	0	62％	100％
Control group	50	22	3	16	9	44％	82％

The treated group was differential compared to the control group (P < 0.05).

6. Effect determination

The effective rate of the formula provided by the invention is 100%, the cure rate is 62%, and the cure effect is obviously better than that of a control group.

The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.

Claims

1. A formula for preventing and treating hyperuricemia and gout, which is characterized by comprising carrot and honey.

2. The formulation of claim 1, wherein the formulation comprises the following components in parts by weight: 10-50 parts of carrot and 1-10 parts of honey.

3. The formulation of claim 2, wherein the formulation comprises the following components in parts by weight: 15-40 parts of carrot and 2-8 parts of honey.

4. The formulation of claim 3, wherein the formulation comprises the following components in parts by weight: 20-30 parts of carrot and 4-6 parts of honey.

5. Use of the formulation according to any one of claims 1 to 4 for the preparation of a medicament for the prevention and treatment of hyperuricemia and gout.