CN112472689B - 药物组合物 - Google Patents

药物组合物 Download PDF

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Publication number
CN112472689B
CN112472689B CN202011316904.7A CN202011316904A CN112472689B CN 112472689 B CN112472689 B CN 112472689B CN 202011316904 A CN202011316904 A CN 202011316904A CN 112472689 B CN112472689 B CN 112472689B
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CN
China
Prior art keywords
pharmaceutical composition
formoterol
corticosteroid
compound
weight
Prior art date
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Application number
CN202011316904.7A
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English (en)
Chinese (zh)
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CN112472689A (zh
Inventor
斯图尔特·科尔
蒂莫西·詹姆斯·诺克斯
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Mexichem Fluor SA de CV
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Mexichem Fluor SA de CV
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57750288&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN112472689(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1521456.2A external-priority patent/GB201521456D0/en
Priority claimed from GB1615916.2A external-priority patent/GB2554092A/en
Application filed by Mexichem Fluor SA de CV filed Critical Mexichem Fluor SA de CV
Publication of CN112472689A publication Critical patent/CN112472689A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202011316904.7A 2015-12-04 2016-12-02 药物组合物 Active CN112472689B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB1521456.2A GB201521456D0 (en) 2015-12-04 2015-12-04 Pharmaceutical composition
GB1521456.2 2015-12-04
GB1615916.2A GB2554092A (en) 2016-09-19 2016-09-19 Pharmaceutical composition
GB1615916.2 2016-09-19
CN201680071126.5A CN108289843B (zh) 2015-12-04 2016-12-02 药物组合物
PCT/GB2016/053812 WO2017093758A1 (en) 2015-12-04 2016-12-02 Pharmaceutical composition

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680071126.5A Division CN108289843B (zh) 2015-12-04 2016-12-02 药物组合物

Publications (2)

Publication Number Publication Date
CN112472689A CN112472689A (zh) 2021-03-12
CN112472689B true CN112472689B (zh) 2023-01-17

Family

ID=57750288

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202011316904.7A Active CN112472689B (zh) 2015-12-04 2016-12-02 药物组合物
CN201680071126.5A Active CN108289843B (zh) 2015-12-04 2016-12-02 药物组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201680071126.5A Active CN108289843B (zh) 2015-12-04 2016-12-02 药物组合物

Country Status (11)

Country Link
US (3) US11559505B2 (https=)
EP (4) EP3556348B1 (https=)
JP (3) JP6899824B2 (https=)
CN (2) CN112472689B (https=)
AU (3) AU2016364650B2 (https=)
BR (2) BR112018011266B1 (https=)
CA (1) CA3007050C (https=)
ES (4) ES3060273T3 (https=)
MX (1) MX375783B (https=)
WO (1) WO2017093758A1 (https=)
ZA (1) ZA201803678B (https=)

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MX387723B (es) 2016-09-19 2025-03-18 Mexichem Fluor Sa De Cv Composición farmacéutica que comprende bromuro de glicopirronio, propionato de fluticasona y 1,1-difluoroetano.
MX384545B (es) 2016-09-19 2025-03-14 Mexichem Fluor Sa De Cv Composicion farmaceutica
US11260052B2 (en) 2016-09-19 2022-03-01 Mexichem Fluor S.A. De C.V. Pharmaceutical composition
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GB2584686A (en) * 2019-06-11 2020-12-16 Mexichem Fluor Sa De Cv Methods
CN110840864B (zh) * 2019-12-20 2022-02-22 广州健康元呼吸药物工程技术有限公司 一种β2受体激动剂吸入气雾剂及包含该吸入气雾剂的产品
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AU2019202875B2 (en) 2020-03-12
CA3007050C (en) 2020-12-08
US20190247339A1 (en) 2019-08-15
MX375783B (es) 2025-03-07
EP3556347B1 (en) 2021-03-24
CN108289843B (zh) 2021-08-17
WO2017093758A1 (en) 2017-06-08
AU2019202875A1 (en) 2019-05-16
US20200009089A1 (en) 2020-01-09
JP6899824B2 (ja) 2021-07-07
JP6931383B2 (ja) 2021-09-01
JP2020073516A (ja) 2020-05-14
ES2796177T3 (es) 2020-11-26
JP2020073515A (ja) 2020-05-14
ES2869176T3 (es) 2021-10-25
EP3383366B2 (en) 2024-06-05
ES2796177T5 (es) 2024-10-29
AU2019202874B2 (en) 2020-03-12
ES2866175T3 (es) 2021-10-19
AU2016364650A1 (en) 2018-06-21
MX2018006800A (es) 2018-11-09
EP3556348A1 (en) 2019-10-23
EP3701940A1 (en) 2020-09-02
US11559505B2 (en) 2023-01-24
JP2019500340A (ja) 2019-01-10
EP3383366B1 (en) 2020-03-25
BR112018011266B1 (pt) 2023-11-21
US20200069619A1 (en) 2020-03-05
ZA201803678B (en) 2026-03-25
CN108289843A (zh) 2018-07-17
CN112472689A (zh) 2021-03-12
BR112018011266A2 (pt) 2018-11-21
EP3383366A1 (en) 2018-10-10
ES3060273T3 (en) 2026-03-25
EP3701940B1 (en) 2025-11-12
JP6899889B2 (ja) 2021-07-07
US11559507B2 (en) 2023-01-24
CA3007050A1 (en) 2017-06-08
AU2019202874C1 (en) 2020-08-06
AU2019202874A1 (en) 2019-05-16
EP3556347A1 (en) 2019-10-23
US11559506B2 (en) 2023-01-24
AU2016364650B2 (en) 2019-04-04
BR122020022602B1 (pt) 2024-03-05
EP3556348B1 (en) 2021-02-03

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