CN112426451A - 一种治疗禽常见传染病感染的中药组合及其制备方法与应用 - Google Patents
一种治疗禽常见传染病感染的中药组合及其制备方法与应用 Download PDFInfo
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Abstract
本发明提供了一种治疗禽常见传染病感染的中药组合及其制备方法与应用，属于中兽药技术领域。本发明中药组合包括A、B组分，其中A组分包括金银花，板蓝根，连翘；B组分为：黄芩，黄芪，栀子，地黄，玄参，黄连，穿心莲，甘草，白头翁。其中制备A经过提取、回流等方式进行浓缩提取，乙醇澄清；B组分通过煎煮浓缩、澄清剂澄清制备得到。本发明中药组合物在制备禽常见传染病的药物中的应用。本发明中药组合物具有副作用小，显效快，症状消失快，效果好等特点。
Description
技术领域
本发明属于中兽药技术领域，涉及一种治疗禽常见传染病感染的中药组合及其制备方法，尤其是涉及金银花、板蓝根、连翘、黄芪、黄芩等中药组合配方的制备方法。
背景技术
禽常见传染病畜禽上呼吸道疾病是临床上的常发病，发生呼吸道疾病的同时,往往并发或继发其他感染,特别是并发大肠杆菌感染,给畜禽养殖业造成极大的经济损失。传统常用中药都有其独特的作用。黄芩、黄芪、板蓝根、栀子、地黄、连翘、玄参、金银花、黄连、穿心莲、甘草等药材均具有清热解毒、抗菌抗病毒的作用，有些还可以提高机体免疫功能。黄芩与黄连、板蓝根、金银花等配伍，有抗菌、抗病毒的功效，穿心莲配伍甘草，大大增强祛痰止咳、宣胸宣肺的功效，利用这些天然中药的配伍优势和功能的相互增强和互补性，提取开发出的中药复方组合，对病毒、细菌、支原体等多种病原混合感染引起的畜禽上呼吸道感染有特效，也可作为机体免疫调节剂，在提高动物机体免疫力和控制动物免疫抑制疾病方面也具有显著的效果。
目前传统的治疗禽传染病的中药组方大多是两味至五味中药，大多也只是单纯的治疗作用，存在吸收慢、显效慢等缺陷。
发明内容
针对现有技术存在的上述问题，本发明申请人提供了一种治疗禽常见传染病感染的中药组合及其制备方法与应用。本发明中药组合物具有副作用小，显效快，症状消失快，效果好等特点。
本发明的技术方案如下：
一种治疗禽常见传染病感染的中药组合，所述中药组合由A组分和B组分组成，其中所述A组分原料及配比为，以重量份数计数：金银花20-30份，板蓝根20-30份，连翘40-60份；B组分原料及配比为：黄芩10-30份，黄芪10-30份，栀子5-10份，地黄5-10份，玄参5-10份，黄连10-15份，穿心莲5-10份，甘草5-10份，白头翁5-10份。
所述具体制备方法如下：
A组分的制备：
步骤1：将金银花、板蓝根与连翘加水浸泡，浸泡结束后回流蒸馏法进行第一次提取，收集提取液；再次加入水进行第二次回流蒸馏提取，收集提取液；
步骤2：将两次收集的提取液合并浓缩，之后向浓缩液中缓慢加入75-95％乙醇搅匀，并静置12-24h，取上清液，灭菌，即得A组分；
B组分的制备：
S1：将权利要求1中所述B组分原料加水进行混合，煎煮2-3小时，过滤得滤渣I和滤液I；向滤渣I加入水，再次煎煮1-2小时，过滤，得到滤液II和滤渣II；
S2：合并滤液I和滤液II并冷却至室温进行浓缩，之后加入ZTC澄清剂，静置12-24h，取上清液，灭菌，即得B组分。
步骤1中第一次浸泡时间为0.5-1小时，第一次回流提取时间1.5-2小时；第二次回流提取时间为1-1.5小时；步骤1中第一次浸泡使用水量为原料质量和的8-10倍，第二次浸泡使用水量为原料质量和的6-8倍。
步骤2中浓缩方法采用双效浓缩器进行浓缩，各效真空度和蒸发温度为：一效压力为-0.04～-0.07MPa，温度为60-85℃；二效压力为-0.06～-0.10MPa，温度为60-75℃。
S2中将滤液I和滤液II浓缩至密度为1.10～1.20g/cm3；浓缩方法采用双效浓缩器，各效真空度和蒸发温度为：一效压力为-0.04～-0.07MPa，温度为60-85℃；二效压力为-0.06～-0.10MPa，温度为60-75℃。
所述中药组合在制备禽常见传染病的药物中的应用。
所述禽常见传染病为上呼吸道疾病、禽流感、非典型新城疫。
所述中药组合物加入或者不加入药学上可以接受的辅料，制备成临床上可接受的制剂。
本发明有益的技术效果在于：
本发明主要用于防治畜禽上呼吸道疾病，对病毒、细菌、支原体等多种病原混合感染引起的畜禽上呼吸道感染有特效。同时还可以提高畜禽的免疫力。具有副作用小，显效快，症状消失快，效果好等特点。
本发明组合使用不仅可以治疗畜禽上呼吸道感染,如传染性支气管炎、传染性喉气管炎等疾病，还能治疗鸡常见传染病如禽流感、非典型新城疫，平时预防可使疾病发生率明显降低，大大减轻发病症状，有效降低死亡率。同时口服液的剂型，可在饮水中迅速分散，畜禽通过饮水给药，方便且利于吸收，在畜禽体内生物利用度大,能够达到迅速起效的目的，安全无副作用，具有显著的经济效益与社会效益。
附图说明
图1为本发明流程示意图。
具体实施方式
下面结合实施例和示例图，对本发明进行具体描述。
实施例1
金银花20-30份，板蓝根20-30份，连翘40-60份；B组分原料及配比为：黄芩10-30份，黄芪10-30份，栀子5-10份，地黄5-10份，玄参5-10份，黄连10-15份，穿心莲5-10份，甘草5-10份，白头翁5-10份。
产品A组分按重量份数配制而成：金银花20份，板蓝根20份，连翘60份；产品A制备方法如下:回流提取进行两次，第一次采用原料药8倍水进行1.5小时，第二次加入6倍水进行1小时。在进行第一次回流提取前将原料药先用水浸0.5小时。对提取液进行浓缩时，浓缩至药液质量为原料药质量的4倍。加入2倍量90％乙醇静置24小时；取上清液进行配液，灌装，灭菌。
产品B产品B组分按重量份数配制而成：黄芩20份，黄芪30份，栀子10份，地黄10份，玄参5份，黄连10份，穿心莲5份，甘草5份，白头翁5份。其制备方法如下:(1)按上述重量份数分别称取各原料；(2)将上述各原料加入所述原料总重量8倍的水,煎煮3小时，过滤，得滤液和滤渣；(3)将滤渣加入总重量6倍的水,煎煮2小时，过滤，得滤液和滤渣；(4)将上述两步骤的滤液自然冷却,并浓缩达到密度为1.20；(5)加入ZTC澄清剂，静置24小时；(6)取上清液进行配液，灌装，灭菌。其中，两次煎煮时水的温度为90℃。
所述浓缩方法采用双效浓缩器，各效真空度和蒸发温度为：一效压力位-0.05MPa，85℃；二效压力为-0.08MPa，75℃。药液浓缩至相对密度1.20g/cm3。
实施例2
产品A组分按重量份数配制而成：金银花30份，板蓝根30份，连翘40份。产品A制备方法如下:回流提取进行两次，第一次采用原料药10倍水进行2小时，第二次加入8倍水进行1.5小时。在进行第一次回流提取前将原料药先用水浸1小时。对提取液进行浓缩时，浓缩至药液质量为原料药质量的6倍。加入2倍量95％乙醇静置24小时；取上清液进行配液，灌装，灭菌。
产品B组分按重量份数配制而成：黄芩10份，黄芪20份，栀子10份，地黄10份，玄参10份，黄连15份，穿心莲5份，甘草5份，白头翁5份其制备方法如下:(1)按上述重量份数分别称取各原料；(2)将上述各原料加入所述原料总重量12倍的水，煎煮2.5小时，过滤，得滤液和滤渣；(3)将滤渣加入总重量10倍的水，煎煮1.5小时，过滤，得滤液和滤渣；(4)将上述两步骤的滤液自然冷却,并浓缩达到密度为1.30；(5)加入ZTC澄清剂，静置24小时；(6)取上清液进行配液，灌装，灭菌。其进一步的技术方案为：所述两次煎煮时水的温度为100℃。浓缩方法采用双效浓缩器，各效真空度和蒸发温度为：一效压力为-0.07MPa，温度为85℃；二效压力为-0.10MPa，温度为75℃。药液浓缩至相对密度1.25g/cm3。
测试例
将实施例1中制备得到的中药组合物进行试验
白羽肉鸡使用产品A+B的临床试验报告
试验目的：了解产品A+B在白羽肉鸡饲养过程中发病情况的对比，及了解代替化学药品的无抗解决方案。
试验时间：2019.6.15～2019.6.19
试验地点：秦皇岛市抚宁县大新寨
试验药品：产品A1000ml/瓶，产品B1000ml/瓶
试验动物及分组：21日龄白羽肉鸡
试验组：7万羽
对照组：7万羽
试验方法：分为试验组和对照组，同样的饲养管理及设备，在鸡群不稳定时辩证后按照给药方案进行药物添加，观察控制情况。
投药方案：产品A0.5mL/kg体重，产品B0.5mL/kg体重，连用4天。
试验结果：
Claims (8)
1.一种治疗禽常见传染病感染的中药组合，其特征在于，所述中药组合由A组分和B组分组成，其中所述A组分原料及配比为，以重量份数计数：金银花20-30份，板蓝根20-30份，连翘40-60份；B组分原料及配比为：黄芩10-30份，黄芪10-30份，栀子5-10份，地黄5-10份，玄参5-10份，黄连10-15份，穿心莲5-10份，甘草5-10份，白头翁5-10份。
2.一种如权利要求1所述的治疗禽常见传染病感染的中药组合的制备方法，其特征在于，所述具体制备方法如下：
A组分的制备：
步骤1：将金银花、板蓝根与连翘加水浸泡，浸泡结束后回流蒸馏法进行第一次提取，收集提取液；再次加入水进行第二次回流蒸馏提取，收集提取液；
步骤2：将两次收集的提取液合并浓缩，之后向浓缩液中缓慢加入75-95％乙醇搅匀，并静置12-24h，取上清液，灭菌，即得A组分；
步骤1中第一次浸泡时间为0.5-1小时，第一次回流提取时间1.5-2小时；第二次回流提取时间为1-1.5小时；步骤1中第一次浸泡使用水量为原料质量和的8-10倍，第二次浸泡使用水量为原料质量和的6-8倍；
B组分的制备：
S1：将权利要求1中所述B组分原料加水进行混合，煎煮2-3小时，过滤得滤渣I和滤液I；向滤渣I加入水，再次煎煮1-2小时，过滤，得到滤液II和滤渣II；
S2：合并滤液I和滤液II并冷却至室温进行浓缩，之后加入ZTC澄清剂，静置12-24h，取上清液，灭菌，即得B组分。
3.根据权利要求2所述的治疗禽常见传染病感染的中药组合的制备方法，其特征在于，步骤1中第一次浸泡时间为0.5-1小时，第一次回流提取时间1.5-2小时；第二次回流提取时间为1-1.5小时；步骤1中第一次浸泡使用水量为原料质量和的8-10倍，第二次浸泡使用水量为原料质量和的6-8倍。
4.根据权利要求2所述的治疗禽常见传染病感染的中药组合的制备方法，其特征在于，步骤2中浓缩方法采用双效浓缩器进行浓缩，各效真空度和蒸发温度为：一效压力为-0.04～-0.07MPa，温度为60-85℃；二效压力为-0.06～-0.10MPa，温度为60-75℃。
5.根据权利要求2所述的治疗禽常见传染病感染的中药组合的制备方法，其特征在于，S2中将滤液I和滤液II浓缩至密度为1.10～1.20g/cm3；浓缩方法采用双效浓缩器，各效真空度和蒸发温度为：一效压力为-0.04～-0.07MPa，温度为60-85℃；二效压力为-0.06～-0.10MPa，温度为60-75℃。
6.如权利要求1中所述中药组合在制备禽常见传染病的药物中的应用。
7.根据权利要求6所述中药组合在制备禽常见传染病的药物中的应用，其特征在于，所述禽常见传染病为上呼吸道疾病、禽流感、非典型新城疫。
8.根据权利要求6所述中药组合在制备禽常见传染病的药物中的应用，其特征在于，所述中药组合物加入或者不加入药学上可以接受的辅料，制备成临床上可接受的制剂。
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