CN108079104A - 一种治疗鸡葡萄球菌病的中药口服液及其制备方法 - Google Patents
一种治疗鸡葡萄球菌病的中药口服液及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗鸡葡萄球菌病的中药口服液的制备方法，包括黄连、黄芩、黄柏、栀子、防己、川芎、当归。本发明中，按计量称取各组分，两次加水后高温回流提取，提取液过滤后，合并提取液，减压浓缩至相对密度为1.15制得浓缩液，再次加水提取，收集蒸馏液，将蒸馏液超微过滤、灭菌、定容后制得口服液。连续服用本药物3～5天后，与未进行药物治疗组相比，病鸡皮肤状况明显改善，本药治疗葡萄球菌病疗效显著，并且毒副作用小，休药期短，成本低，用药后无残留，无毒副作用。
Description
技术领域
本发明属于鸡葡萄球菌病治疗技术领域，尤其是一种治疗鸡葡萄球菌病的中药口服液及其制备方法。
背景技术
鸡葡萄球菌病是由金黄色葡萄球菌引起的一种急性或慢性环境性传染病。其广泛分布在自然界的土壤、空气、水、饲料、物体表面以及鸡的羽毛、皮肤、黏膜、肠道和粪便中。其主要特征是肉鸡呈急性败血症、脐炎、中雏发生皮肤病，呈皮下出血性炎症，皮肤出血和坏死；成年鸡呈现关节炎、腱鞘炎、关节滑膜炎、爪垫脓疡等。主要危害40～60日龄中雏，死亡率达10％～50％。金黄色葡萄球菌病的主要传染途径是皮肤和黏膜的创伤，也可因直接接触或空气传播，雏鸡通过脐带感染也较常见。
许多国家都有鸡葡萄球菌病发生，我国于1981年在北京发现该病。近年来，随着我国养鸡业的不断发展，该病已经成为一些养鸡场的常见病之一，对养鸡业造成很大危害。目前常见的治疗手段是使用庆大霉素或卡那霉素等抗生素药物，但是抗生素带来的兽药残留、耐药性等问题对养殖业危害严重。因此，本发明提供了一种治疗鸡葡萄球菌病的中药口服液。
发明内容
本发明的目的在于克服现有技术的不足，提供组方科学、配伍合理、治疗效果好、无毒副作用的一种治疗一种治疗鸡葡萄球菌病的中药口服液。
本发明采取的技术方案是：
一种治疗鸡葡萄球菌病的中药口服液，其特征在于：包括按重量份数混合的以下组分：
而且，包括按重量份数混合的以下组分：
本发明的另一个目的是提供一种治疗鸡葡萄球菌病的中药口服液的制备方法，其特征在于：包括以下步骤：
(1)按计量称取黄连、黄芩、黄柏、栀子、防己、川芎、当归，放入回流提取罐内，加水后高温回流提取，提取液过滤后备用；
(2)将药渣加入回流提取罐内，加水后进行第二次回流提取，提取液过滤后备用；
(3)将步骤⑴和⑵的提取液合并，减压浓缩至相对密度为1.15制得浓缩液；
(4)将浓缩液后超微过滤、灭菌、定容后制得口服液。
而且，步骤⑴所述提取中：药物组分和水的重量比为1:12，时间为1小时；步骤⑵所述提取中：药渣和水的重量比为1:5，时间为0.5小时。
本发明的优点和积极效果是：
本发明中，将黄连、黄芩、黄柏、栀子、防己、川芎、当归进行提取，制得浓缩液，经二次提取后制得口服液，各组分相互配合，协同作用，具有杀菌抑菌、免疫功能调节、诱生干扰素、对抗细菌的功效，能有效的治疗细菌性疾病，无药物残留，无毒副作用、不会产生耐药性。
具体实施方式
下面结合实施例，对本发明进一步说明，下述实施例是说明性的，不是限定性的，不能以下述实施例来限定本发明的保护范围。
一种治疗鸡葡萄球菌病的中药口服液，本发明的创新在于：包括按重量份数混合的以下组分：
更优选的方案是：包括按重量份数混合的以下组分：
本发明中，黄连泻火解毒，抗菌，抗病毒，抗炎、抗腹泻；黄芩具有泻火解毒、止血安胎等功效，临床抗菌性较好；黄柏清热燥湿，泻火除蒸，解毒疗疮；栀子护肝利胆、降压镇静、止血消肿；防己用于风湿痹痛，水肿脚气，小便不利，湿疹疮毒；川芎活血祛瘀作用广泛，适宜瘀血阻滞各种病症；祛风止痛，可治头风头痛、风湿痹痛等症；当归可补血和血，调经止痛，润燥滑肠，有抗癌、抗老防老、免疫之功效。
实施例1
一种治疗鸡葡萄球菌病的中药口服液的制备方法包括以下步骤：
黄连5份、黄芩10份、黄柏5份、栀子10份、防己3份、川芎10份、当归3份
(1)按计量称取黄连、黄芩、黄柏、栀子、防己、川芎、当归，放入回流提取罐内，加水后高温回流提取，提取液过滤后备用；
(2)将药渣加入回流提取罐内，加水后进行第二次回流提取，提取液过滤后备用；
(3)将步骤⑴和⑵的提取液合并，减压浓缩至相对密度为1.15制得浓缩液；
(4)将浓缩液后超微过滤、灭菌、定容后制得口服液。
而且，步骤⑴所述提取中：药物组分和水的重量比为1:12，时间为1小时；步骤⑵所述提取中：药渣和水的重量比为1:5，时间为0.5小时。
而且，将(4)的浓缩液合并后超微过滤(0.45微米滤膜)、灭菌(121摄氏度，15min)后，加水定容至1000ml制得口服液。
实施例2
黄连6份、黄芩10份、黄柏6份、栀子10份、防己2份、川芎10份、当归2份
按实施例1中步骤进行制备。
实施例3
黄连6份、黄芩9份、黄柏6份、栀子9份、防己5份、川芎9份、当归5份
按实施例1中步骤进行制备。
临床试验：
例如：2017年4月，某养殖场5500只蛋鸡中出现皮肤病，胸部、前腹部羽毛稀少或脱毛，皮肤呈紫黑色浮肿，有的自然破溃则局部沾污。剪开皮肤可见整个胸、腹部皮下充血、溶血，呈弥漫性紫红色或黑红色，积有大量胶冻样粉红色或黄红色水肿液。鉴别诊断确诊为鸡葡萄球菌病后，遂用实施例3药物，用药3～5天后，与未进行药物治疗组相比，病鸡皮肤状况明显改善，治愈率达96％。
本发明中，按计量称取黄连、黄芩、黄柏、栀子、防己、川芎、当归，加水煎煮两次，合并滤液后静置，浓缩，烘干后粉碎，加入蔗糖，造粒过筛后烘干，再次过筛制得成品。使用时按一定比例与饲料混合，然后供病鸡食用，连续用药一段时间后，本药治疗葡萄球菌病疗效显著，并且毒副作用小，休药期短，成本低，用药后无残留，无毒副作用。
Claims (3)
1.一种治疗鸡葡萄球菌病的中药口服液的制备方法，其特征在于：包括按重量份数混合的以下组分：
。
2.根据权利要求1所述的一种治疗鸡葡萄球菌病的中药口服液的制备方法，其特征在于：包括按重量份数混合的以下组分：
。
3.根据权利要求1或2所述的一种治疗鸡葡萄球菌病的中药口服液的制备方法，其特征在于：包括以下步骤：
(1)按计量称取黄连、黄芩、黄柏、栀子、防己、川芎、当归，放入回流提取罐内，加水后高温回流提取，提取液过滤后备用；
(2)将药渣加入回流提取罐内，加水后进行第二次回流提取，提取液过滤后备用；
(3)将步骤⑴和⑵的提取液合并，减压浓缩至相对密度为1.15制得浓缩液；
(4)将浓缩液后超微过滤、灭菌、定容后制得口服液。
而且，步骤⑴所述提取中：药物组分和水的重量比为1:12，时间为1小时；步骤⑵所述提取中：药渣和水的重量比为1:5，时间为0.5小时。
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| CN110179859B (zh) * | 2019-06-27 | 2021-09-24 | 香港科技大学深圳研究院 | 防己提取物及防己诺林碱在制药中的应用 |
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