CN104435626A - 一种治疗畜禽病毒性疾病中药口服液及其制备方法 - Google Patents
一种治疗畜禽病毒性疾病中药口服液及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗畜禽病毒性疾病中药口服液,第一步先将桑叶、连翘、金银花、黄芩、黄连、甘草、鱼腥草、山楂、大蒜、紫草、白芍、山甲、贯众、秦皮和知母进行提取,制得浓缩液,第二步将薄荷和葛根进行提取,制得蒸馏液,将浓缩液和蒸馏液合并后制得口服液,采用这种方式后可将薄荷油和葛根素的提取含量大幅增加,另外葛根、鱼腥草、贯众、知母、紫草为君药,黄连、黄芩、白芍、山甲、金银花和桑叶为臣药,连翘、薄荷、大蒜、秦皮为佐药,甘草为使药,各组分相互配合,协同作用,具有病毒抑杀、免疫功能调节、诱生干扰素、对抗毒素的功效,能有效的治疗病毒性疾病,无药物残留,无毒副作用、不会产生耐药性。
Description
技术领域
本发明属于畜禽病毒性疾病治疗技术领域,尤其是一种治疗畜禽病毒性疾病中药口服液及其制备方法。
背景技术
我国的畜牧养殖业发展势头非常迅猛,但随着饲养方式的改变、外来品种的引进以及畜禽的流通,各种疫病的发生和流行日益复杂,其中由病毒引起的疾病,因病毒变异、化学药物的禁止使用等方面的原因,使疾病更加难以控制,如近年来的禽流感、圆环病毒感染等,这些疾病危害性极大,严重影响了畜禽的生长,使乳、肉、毛、革、蛋等畜禽产品质量下降,数量减少,如果防治不及时,易引起大批畜禽的死亡,给养殖业造成了巨大的经济损失。同时,有些病毒性疾病可以同时感染人畜,对人们的身体健康也造成了威胁。
目前,防治病毒性疾病的主要手段有隔离或扑杀患病畜禽、疫苗注射和药物治疗,其中第一项较常采用,比如某地鸡场部分蛋鸡感染禽流感,当地一定面积的地域内的鸡场的鸡全部扑杀,给当地养殖业造成了及其严重的经济损失,第二项有一定的防治效果,但随着病毒的变异等因素导致效果逐年下降,第三项的药物种类很多,包括中药制剂和西药制剂,但西药制剂存在抗药性、药物残留等方便的缺点,使得强毒株、变异毒株不断出现,使用剂量越来越大,但治疗效果越来越差,中药制剂避免了抗药性和药物残留的缺点,但较常使用的组方不科学、配伍混乱,这样也会造成治疗效果变差。
发明内容
本发明的目的在于克服现有技术的不足,提供组方科学、配伍合理、治疗效果好、无毒副作用的一种治疗畜禽病毒性疾病中药口服液。
本发明采取的技术方案是:
一种治疗畜禽病毒性疾病中药口服液,其特征在于:包括按重量份数混合的以下组分:
而且,包括按重量份数混合的以下组分:
本发明的另一个目的是提供一种治疗畜禽病毒性疾病中药口服液的制备方法,其特征在于:包括以下步骤:
⑴按计量称取桑叶、连翘、金银花、黄芩、黄连、甘草、鱼腥草、山楂、大蒜、紫草、白芍、山甲、贯众、秦皮和知母,放入回流提取罐内,加水后高温回流提取,提取液过滤后备用;
⑵将药渣加入回流提取罐内,加水后进行第二次回流提取,提取液过滤后备用;
⑶将步骤⑴和⑵的提取液合并,减压浓缩至相对密度为1.15制得浓缩液;
⑷按计量称取薄荷和葛根,放入回流提取罐内,加水后高温提取,收集蒸馏液;
⑸将药渣加入回流提取罐内,加水后进行第二次提取,收集蒸馏液;
⑹将步骤⑷和⑸的蒸馏液合并,再与步骤⑶的浓缩液合并后超微过滤、灭菌、定容后制得口服液。
而且,步骤⑴所述提取中:药物组分和水的重量比为1:12,时间为1小时;步骤⑵所述提取中:药渣和水的重量比为1:5,时间会0.5小时。
而且,步骤⑶所述提取中:药物组分和水的重量比为1:8,时间为1小时;步骤⑸所述提取中:药渣和水的重量比为1:4,时间会0.5小时。
本发明的优点和积极效果是:
本发明中,第一步先将桑叶、连翘、金银花、黄芩、黄连、甘草、鱼腥草、山楂、大蒜、紫草、白芍、山甲、贯众、秦皮和知母进行提取,制得浓缩液,第二步将薄荷和葛根进行提取,制得蒸馏液,将浓缩液和蒸馏液合并后制得口服液,采用这种方式后可将薄荷油和葛根素的提取含量大幅增加,另外葛根、鱼腥草、贯众、知母、紫草为君药,黄连、黄芩、白芍、山甲、金银花和桑叶为臣药,连翘、薄荷、大蒜、秦皮为佐药,甘草为使药,各组分相互配合,协同作用,具有病毒抑杀、免疫功能调节、诱生干扰素、对抗毒素的功效,能有效的治疗病毒性疾病,无药物残留,无毒副作用、不会产生耐药性。
具体实施方式
下面结合实施例,对本发明进一步说明,下述实施例是说明性的,不是限定性的,不能以下述实施例来限定本发明的保护范围。
一种治疗畜禽病毒性疾病中药口服液,本发明的创新在于:包括按重量份数混合的以下组分:
更优选的方案是:包括按重量份数混合的以下组分:
本发明中,葛根,甘辛而凉,入脾胃经,鱼腥草归肺,贯众、知母入肺经,紫草归心、肝经,均有清热解毒之功效,共为主药。以黄连、黄芩、白芍、山甲清热燥湿,厚肠止利,金银花、桑叶加强清热解毒化湿之功,共为臣药。连翘、薄荷辛凉疏散头面风热,山楂,行气散瘀,大蒜散痈肿魇疮,除风邪,杀毒气”,秦皮,燥湿收涩,共为佐药。甘草甘缓和中,调和诸药,为本方使药。以上各药相辅相成,达到扶正祛邪、清热化湿、宁心安神之功效。
葛根的有效成分为黄酮类物质,但葛根黄酮水溶性不佳,葛根中又含有大量淀粉,葛根单独煎制,有利于葛根淀粉等成分溶出,对葛根黄酮及方中其他难溶性、挥发性有效成分亦有增溶作用,而薄荷属于含挥发油的中药,连同葛根提取,可有效保证药材内有效成分含量提取完全,经过比对,采用本发明方法提取的薄荷油和葛根素较全部组分一次性提取的含量分别提高70%和46%。
实施例1
一种治疗畜禽病毒性疾病中药口服液的制备方法包括以下步骤:
桑叶10kg,连翘5kg、薄荷5Kg、金银花10Kg、葛根15kg、黄芩5kg、黄连5kg、甘草5kg、鱼腥草10kg、山楂10kg、大蒜10kg、紫草5kg、白芍15kg、山甲10kg、贯众5kg、秦皮5kg、知母5kg
⑴按计量称取桑叶、连翘、金银花、黄芩、黄连和甘草,放入回流提取罐内,加水后高温(100摄氏度)回流提取,提取液过滤后备用;
药物组分和水的重量比为1:12,时间为1小时;
⑵将药渣加入回流提取罐内,加水后进行第二次回流(100摄氏度)提取,提取液过滤后备用;
药渣和水的重量比为1:5,时间会0.5小时;
⑶将步骤⑴和⑵的提取液合并,减压浓缩(60-80℃)至相对密度为1.15制得浓缩液;
⑷按计量称取薄荷和葛根,放入回流提取罐内,加水后高温(100摄氏度)提取,收集蒸馏液;药物组分和水的重量比为1:8,时间为1小时;
⑸将药渣加入回流提取罐内,加水后进行第二次提取(100摄氏度),收集蒸馏液;
药渣和水的重量比为1:4,时间会0.5小时
⑹将步骤⑷和⑸的蒸馏液合并,再与步骤⑶的浓缩液合并后超微过滤(0.45微米滤膜)、灭菌(121摄氏度,15min)后,加水定容至1000ml制得口服液。
实施例2
桑叶20kg,连翘15kg、薄荷15Kg、金银花20Kg、葛根25kg、黄芩15kg、黄连15kg、甘草15kg、鱼腥草20kg、山楂20kg、大蒜20kg、紫草15kg、白芍25kg、山甲20kg、贯众15kg、秦皮15kg、知母15kg
按实施例1中步骤进行制备。
实施例3
桑叶15kg,连翘10kg、薄荷10Kg、金银花15Kg、葛根20kg、黄芩10kg、黄连10kg、甘草10kg、鱼腥草15kg、山楂15kg、大蒜15kg、紫草10kg、白芍20kg、山甲15kg、贯众10kg、秦皮10kg、知母10kg
按实施例1中步骤进行制备。
应用实施例1
对自然感染禽流感病毒的鸡群,使用实施例3的配方,分别给予不同剂量的口服液,混饮后,通过与感染对照组比较,发病鸡群的临床症状明显减轻,产蛋率上升。
中剂量组与高剂量组的治疗效果达到了理想的要求;禽泰克对照组治疗效果较为理想,但产蛋率的恢复情况明显不如本发明。治疗结果见表1:
表1:治疗结果
应用实施例2
对自然发生牛流行性感冒的病牛,使用实施例3的配方,分别给予不同剂量的口服液,混饮后,通过与感染对照组进行比较,发病牛的临床症状明显减轻。
中剂量组和高剂量组的治疗效果达到了理想的要求;高剂量组的治疗效果与复方氨基比林注射液对照组基本一致,结果见表2:
表2:治疗结果
应用实施例3
2014年于天津一宠物医院,泰迪犬,母,两岁。体重3.7kg,晚上突然发病,精神沉郁,食欲减少,大量黏液性,不透明鼻分泌物和咳嗽,病犬疲软无力,经实验室诊断为犬副流感。使用实施例3的配方,病犬情况如下:
3天后,体温逐渐恢复正常,精神转好;4天后,咳嗽症状消失,鼻分泌物减少,饮食欲恢复。
应用实施例4
对自然感染鸭瘟病毒的病鸭,使用实施例3的配方,分别给予不同剂量的口服液,混饮后,通过与感染对照组进行比较,发病鸭的临床症状明显减轻。
中剂量组和高剂量组的治疗效果达到了理想的要求;高剂量组的治疗效果与双黄连口服液对照组对照组基本一致,结果见表3:
表3:治疗效果
本发明中,第一步先将桑叶、连翘、金银花、黄芩、黄连、甘草、鱼腥草、山楂、大蒜、紫草、白芍、山甲、贯众、秦皮和知母进行提取,制得浓缩液,第二步将薄荷和葛根进行提取,制得蒸馏液,将浓缩液和蒸馏液合并后制得口服液,采用这种方式后可将薄荷油和葛根素的提取含量大幅增加,另外葛根、鱼腥草、贯众、知母、紫草为君药,黄连、黄芩、白芍、山甲、金银花和桑叶为臣药,连翘、薄荷、大蒜、秦皮为佐药,甘草为使药,各组分相互配合,协同作用,具有病毒抑杀、免疫功能调节、诱生干扰素、对抗毒素的功效,能有效的治疗病毒性疾病,无药物残留,无毒副作用、不会产生耐药性。
Claims (5)
1.一种治疗畜禽病毒性疾病中药口服液,其特征在于:包括按重量份数混合的以下组分:
2.根据权利要求1所述的一种治疗畜禽病毒性疾病中药口服液,其特征在于:包括按重量份数混合的以下组分:
3.根据权利要求1或2所述的一种治疗畜禽病毒性疾病中药口服液的制备方法,其特征在于:包括以下步骤:
⑴按计量称取桑叶、连翘、金银花、黄芩、黄连、甘草、鱼腥草、山楂、大蒜、紫草、白芍、山甲、贯众、秦皮和知母,放入回流提取罐内,加水后高温回流提取,提取液过滤后备用;
⑵将药渣加入回流提取罐内,加水后进行第二次回流提取,提取液过滤后备用;
⑶将步骤⑴和⑵的提取液合并,减压浓缩至相对密度为1.15制得浓缩液;
⑷按计量称取薄荷和葛根,放入回流提取罐内,加水后高温提取,收集蒸馏液;
⑸将药渣加入回流提取罐内,加水后进行第二次提取,收集蒸馏液;
⑹将步骤⑷和⑸的蒸馏液合并,再与步骤⑶的浓缩液合并后超微过滤、灭菌、定容后制得口服液。
4.根据权利要求3所述的一种治疗畜禽病毒性疾病中药口服液的制备方法,其特征在于:步骤⑴所述提取中:药物组分和水的重量比为1:12,时间为1小时;步骤⑵所述提取中:药渣和水的重量比为1:5,时间0.5小时。
5.根据权利要求3所述的一种治疗畜禽病毒性疾病中药口服液的制备方法,其特征在于:步骤⑶所述提取中:药物组分和水的重量比为1:8,时间为1小时;步骤⑸所述提取中:药渣和水的重量比为1:4,时间会0.5小时。
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