CN112423747A - 用于治疗睾丸肾上腺残余瘤和卵巢肾上腺残余瘤的方法 - Google Patents

用于治疗睾丸肾上腺残余瘤和卵巢肾上腺残余瘤的方法 Download PDF

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Publication number
CN112423747A
CN112423747A CN201980043623.8A CN201980043623A CN112423747A CN 112423747 A CN112423747 A CN 112423747A CN 201980043623 A CN201980043623 A CN 201980043623A CN 112423747 A CN112423747 A CN 112423747A
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compound
pharmaceutically acceptable
acceptable salt
administered
formula
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A·豪尔顿
H·格伯
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Spruce Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980043623.8A 2018-04-27 2019-04-26 用于治疗睾丸肾上腺残余瘤和卵巢肾上腺残余瘤的方法 Pending CN112423747A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862663951P 2018-04-27 2018-04-27
US62/663,951 2018-04-27
US201962822815P 2019-03-23 2019-03-23
US62/822,815 2019-03-23
PCT/US2019/029486 WO2019210266A1 (en) 2018-04-27 2019-04-26 Methods for treating testicular and ovarian adrenal rest tumors

Publications (1)

Publication Number Publication Date
CN112423747A true CN112423747A (zh) 2021-02-26

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CN201980043623.8A Pending CN112423747A (zh) 2018-04-27 2019-04-26 用于治疗睾丸肾上腺残余瘤和卵巢肾上腺残余瘤的方法

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Country Link
US (6) US11304950B2 (https=)
EP (3) EP4438124A3 (https=)
JP (1) JP7427655B2 (https=)
CN (1) CN112423747A (https=)
AU (3) AU2019260793B2 (https=)
BR (1) BR112020024062A2 (https=)
CA (1) CA3098562A1 (https=)
ES (1) ES2991516T3 (https=)
MX (1) MX2020011344A (https=)
WO (1) WO2019210266A1 (https=)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
WO2015112642A1 (en) 2014-01-21 2015-07-30 Neurocrine Biosciences, Inc. Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
CN118845788A (zh) 2017-08-14 2024-10-29 云杉生物科学公司 促肾上腺皮质激素释放因子受体拮抗剂
EP4438124A3 (en) 2018-04-27 2024-12-18 Spruce Biosciences, Inc. Methods for treating testicular and ovarian adrenal rest tumors
CA3121920A1 (en) 2018-12-07 2020-06-11 Neurocrine Biosciences, Inc. Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
TW202116324A (zh) * 2019-07-19 2021-05-01 美商雲杉生物科技股份有限公司 治療先天性腎上腺增生之方法
JP7623365B2 (ja) 2019-09-27 2025-01-28 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｃｒｆ受容体アンタゴニストおよび使用方法
BR112023002497A2 (pt) * 2020-08-12 2023-05-02 Spruce Biosciences Inc Métodos e composições para tratamento da síndrome dos ovários policísticos
JP2023540223A (ja) * 2020-08-26 2023-09-22 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｃｒｆ受容体アンタゴニストおよび使用方法
MX2024006064A (es) * 2021-11-19 2024-05-30 Spruce Biosciences Inc Composicion cristalina de tildacerfont y metodos de uso y preparacion de la misma.
US11708372B2 (en) * 2021-11-19 2023-07-25 Spruce Biosciences, Inc. Crystalline composition of tildacerfont and methods of use and preparation thereof

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AU2025204720A1 (en) 2025-07-10
CA3098562A1 (en) 2019-10-31
US12569491B2 (en) 2026-03-10
AU2019260793B2 (en) 2023-05-18
US20250177404A1 (en) 2025-06-05
EP3784233B1 (en) 2024-06-05
WO2019210266A1 (en) 2019-10-31
US20210038604A1 (en) 2021-02-11
US12576084B2 (en) 2026-03-17
AU2019260793A1 (en) 2020-12-17
US20250195527A1 (en) 2025-06-19
US20220211711A1 (en) 2022-07-07
EP4438124A2 (en) 2024-10-02
EP3784233A1 (en) 2021-03-03
US20250064812A1 (en) 2025-02-27
JP2021522340A (ja) 2021-08-30
EP3784233C0 (en) 2024-06-05
EP4438124A3 (en) 2024-12-18
MX2020011344A (es) 2021-02-09
EP4643950A2 (en) 2025-11-05
US11304950B2 (en) 2022-04-19
EP3784233A4 (en) 2022-03-02
BR112020024062A2 (pt) 2021-02-09
JP7427655B2 (ja) 2024-02-05
US20250177403A1 (en) 2025-06-05
EP4643950A3 (en) 2026-01-14
ES2991516T3 (es) 2024-12-03
AU2023203095A1 (en) 2023-06-08
US12569490B2 (en) 2026-03-10

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