CN1124149A - Traditional Chinese medicine sterilizing agent and its preparing method - Google Patents
Traditional Chinese medicine sterilizing agent and its preparing method Download PDFInfo
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- CN1124149A CN1124149A CN 94113162 CN94113162A CN1124149A CN 1124149 A CN1124149 A CN 1124149A CN 94113162 CN94113162 CN 94113162 CN 94113162 A CN94113162 A CN 94113162A CN 1124149 A CN1124149 A CN 1124149A
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Abstract
The traditional Chinese medicine disinfectant comprises loropetalum leaves, oil tung fruit shell and slaked lime as effective components and is prepared by decocting the loropetalum leaves with water, burning the oil tung fruit shell into ashes and mixing the decoction and the ashes with sifted slaked lime. It features high efficacy, wide spectrum, no stimulation, no corrosion and low cost. It has effects of stopping bleeding, allaying itchiness and expediting healing.
Description
The present invention relates to Chinese medicine antiseptic.
Sterilization is to implement one of important means of China's sanitary work " putting prevention first and combining prevention with control " policy.At present, the disinfectant of using in health and epidemic prevention and medical treatment has chlorine-containing disinfectant, peroxide disinfectant, aldehyde disinfectant, quaternary ammonium disinfectant, contains iodine disinfectant, ethanol etc., and kind surplus in the of 20 still is ethanol, iodine tincture, chelated iodine etc. than what use always altogether.Ethanol is invalid to bacterial spore, relatively poor to the hepatitis B surface antigen disinfective action.It is good but cost is higher, iodine raw material dependence on import to contain the iodine disinfectant bactericidal effect.Other chemosterilants or sterilization effect are relatively poor, go out myristylpicolinum bromide as new clean pleasure; Or toxicity, corrosivity are bigger, as carbolic acid.The disinfectant that sterilizing power is strong is damaged wound tissue easily, generally all forbids directly embrocating wound.
Chinese patent application number is 92100929.1, and publication number is the prescription that the application for a patent for invention of CN1075602A has proposed a kind of Chinese medicine antiseptic, and it is made up of Chinese medicines such as Radix Et Rhizoma Rhei, Cortex Moutan, Cortex Magnoliae Officinalis, Flos Caryophylli, Herba Menthae and additives.This side's prescription composition is more, and preparation technology is complicated, and cost is higher.
The purpose of this invention is to provide a kind of efficient, wide spectrum, nonirritant, non-corrosiveness, Chinese medicine antiseptic with low cost.
Active ingredient is floral leaf, Aleurites fordii Hemsl. shell and Calx in the Chinese medicine antiseptic provided by the invention.Its proportioning is: the floral leaf: the Aleurites fordii Hemsl. shell: Calx=18～22: 18～22: contain crude drug 40～55g in 5～9 these disinfectant of every 10ml.
The floral leaf is the stem and leaf that the full thread of section wood belongs to wood in the side, and sweet in the mouth, hardship are cool in nature; Heat-clearing and toxic substances removing is arranged, hemostatic function.Available clinically this product decocting liquid is done the treatment of skin antiseptic and traumatic hemorrhage.The Aleurites fordii Hemsl. shell is the shell of Euphorbiaceae tung tree Aleurites fordii Hemsl., and acrid in the mouth is cold in nature, and detoxifcation is arranged, granulation promoting, insecticidal function.The clinical treatment that is used for surgery carbuncle erysipelas.Calx is that limestone is placed old person after calcining, acrid in the mouth, warm in nature, parasite killing, hemostasis, analgesic therapy effect arranged, the clinical swollen skin infection of multiple traumatic hemorrhage furuncle that is used for.Full side's coordination has stronger sterilization.
Preparation method is with floral leaf decocting, to go into floral leaf decocting liquid with the Calx that sieves behind the Aleurites fordii Hemsl. shell ashing, promptly after filtering.Ca in the gained disinfectant (OH) 2 content should be between 5.0～6.6mg/ml.
The evaluation criterion test shows of above-mentioned Chinese medicine antiseptic acute toxicity in " disinfection technology standard " that Hunan Hygienic ﹠ Epidemic Prevention Station issues according to Ministry of Public Health, this is tried thing and is belonged to nontoxic; According to " disinfection technology standard " middle standards of grading that reflect stimulus intensity that Ministry of Public Health is issued, this disinfectant is 0 minute to guinea pig skin reaction integration, belongs to nonirritant.
Chinese medicine antiseptic provided by the invention has efficiently, the broad-spectrum bactericidal action.Hunan Hygienic ﹠ Epidemic Prevention Station has done following test to the Disinfection Effect of Chinese medicine antiseptic provided by the invention.
Test condition: T:27 ℃ RH:75%
Method of testing: Ministry of Public Health " disinfection technology standard "
1, to bacterial propagule, brood cell's killing effect, sees Table 1
Table 1: Chinese medicine antiseptic is to bacterial propagule, brood cell's killing effect: test strain: bacterium is counted the killing rate (%) of decontaminant concentration effect different time (min) before the sterilization
Individual/ml (mg/l) 5 10 15 30 escherichia coli 3.52 * 10
1Stock solution 3600/99.989 400/99.989 0/100 0/100ATcc2922 staphylococcus aureuses 4.72 * 10
7Stock solution 400/99.998 100/99.999 0/100 1/100ATCC6583 bacillus subtilis black 1.90 * 10
1Stock solution 6000/99.968 4400/99.976 2700/99.998 400/99.998 mutation brood cells (ATCC9372) annotate: experimental control is set up, and molecule is the bacterial population after sterilizing, and denominator is a killing rate.
In the presence of 10% calf serum to brood cell's killing effect, see Table 2: table 2, Chinese medicine antiseptic are counted the killing rate % of disinfectant effect different time (min) to bacterium before the sterilization of brood cell's killing effect test strain in the presence of 10% calf serum
Individual/ml concentration 5 10 15 30 bacillus subtilis black become 9700/99.948 kind of brood cell 1.09 * 10 of stock solution
16000/99.968ATcc9372 1000/99.994+10% calf serum 100/99.999 is annotated: experimental control is set up, molecule is the bacterial population after sterilizing, and denominator is a killing rate.
3. stability test
The sample censorship time detects its bactericidal effect, is placed on then in 56 ℃ of incubators, deposit fortnight after, observe its bactericidal effect situation of change.See Table 3, table 4
Table 3 Chinese medicine antiseptic is to bacterial reproduction, brood cell's killing effect.Test strain: bacterium is counted the killing rate (%) of decontaminant concentration effect different time (min) before the sterilization
Individual/ml 5 10 15 30 escherichia coli 6.2 * 10
1Stock solution 7400/99.998 1000/99.998ATcc25922 1000/99.998 100/99.999 staphylococcus aureuses 2.7 * 10
1Stock solution 4000/99.985 1000/99.992ATCC6538 1000/99.992 0/100.00 bacillus subtilis black 2.4 * 10
1Stock solution 7280/99.969 1800/99.992 mutation brood cells 1200/99.995 140/99.999 (ATcc9372) annotate: test control group is set up, molecule is sterilization back bacterium number, and denominator is a killing rate
Table 4 Chinese medicine antiseptic in the presence of the l0% calf serum to brood cell's killing effect.
Test strain: bacterium is counted the killing rate (%) of decontaminant concentration effect different time (min) before the sterilization individual/mt 5 10 15 30 bacillus subtilis black stock solutions 9400/99.960 4600/99.980 mutation brood cells 2.4 * 10
1(ATcc9372) 2300/99.990 2100/99.991 annotate: experimental control is set up, and molecule is imitated for the antibacterial after sterilizing, and denominator is a killing rate.
4. to the HBsAg failure test, see Table 5
Table 5 Chinese medicine antiseptic is to the 0D value of HBsAg failure test decontaminant concentration effect different time (min)
15 30 60 stock solutions, 000 experiment positive controls, 3.13 experiment negative controls are 0.05 result judge: colorimetry (wavelength 492nm) is zero with blank school.
Positive, otherwise negative
Above-mentioned test shows:
L, this disinfectant can be killed 99.989% escherichia coli in 5 minutes with the stock solution effect, 99.998% staphylococcus aureus; 99.968% bacillus subtilis black variety bud cell.
2, this disinfectant acts on 5 minutes in the presence of the calf serum of l0%, and the bacillus subtilis black variety bud cell of killing with stock solution energy 99.948% illustrates in the presence of Organic substance, and this disinfectant is to brood cell's not influence of killing effect.
3,5 minutes energy l00.00% of this disinfectant stock solution effect ground destroys hbs antigen.
So this disinfectant reaches Ministry of Public Health antiseptic hygiene standard to the killing effect of microorganism.With common disinfectants, 75% ethanol and chelated iodine are compared, and Disinfection Effect is significantly higher than 75% ethanol and is suitable with chelated iodine.
Disinfectant provided by the invention not only has efficiently, wide spectrum, nonirritant, non-corrosive characteristics, and has hemostasis, antipruritic, the effect that promotes wound healing, so sterilize very suitable to surgical wound skin ulcer and eczema.This disinfectant prescription is simple, and is easy to prepare, with low cost, is a kind of Chinese medicine antiseptic that DEVELOPMENT PROSPECT is arranged.
Embodiment 1
190g floral leaf decocting is boiled secondary, each 1 hour, merge the secondary decocting liquid, be concentrated into 1000ml; The 190g Aleurites fordii Hemsl. shell Calx that the back sieves with 70g that incinerates is gone in the above-mentioned decocting liquid, and shake well was placed 12 hours, filtration, and fill is promptly.
Make the skin degerming of multiple operation with above-mentioned disinfection of Chinese drug liquid.Method: field of operation is prepared routinely, substitutes iodine tincture, alcohol disinfecting with disinfectant, from the otch center, around rubbing into gradually, generally embrocates 2-3 times.Clinical observation 74 examples (abdominal operation 38 examples wherein, operation on neck 6 examples, thoracic operation 3 examples, nasal surgery 10 examples, operation on pelvis 10 examples, extremity and osteoarthrosis 7 examples of performing the operation) all obtain primary healing.
Embodiment 2
Prescription is floral leaf 220g, Aleurites fordii Hemsl. shell 200g, Calx 50g.Preparation method is by last example.
Make the preceding skin degerming of injection with above-mentioned prescription disinfection of Chinese drug liquid.Method; With this disinfectant is the center with the injection point, and spiral type is embrocated sterilization from inside to outside, and cases of infection do not take place clinical observation 180 examples.
Embodiment 3
Prescription is floral leaf 210g, Aleurites fordii Hemsl. shell 200g, Calx 84g.The same example of preparation method.
Above-mentioned prescription disinfectant is used for the skin trauma sterilization.To skin trauma, embrocate, irrigate with this disinfectant; Original wound infection person with the continuous soak of this disinfectant, observes 82 examples altogether, except that 7 routine former wound infection severe patients use all the other 75 just all single these disinfectant of using the antibiotics simultaneously.68 examples of primary healing as a result, secondary healing 7 examples.
Embodiment 4
Prescription is floral leaf 210g, Aleurites fordii Hemsl. shell 210g, Calx 80g, the same example of preparation method.
Above-mentioned disinfectant is used for the outer eczema local every day 3-5 times of putting on the skin, treats 28 examples, have significantly antipruritic, eliminate pimple and reduce the effect that rotten to the corn face oozes out, effective percentage is 100%.
Claims (3)
1, Chinese medicine antiseptic, active ingredient wherein are the floral leaves, Aleurites fordii Hemsl. shell and Calx.
2, Chinese medicine antiseptic according to claim 1, the proportioning that it is characterized in that floral leaf, Aleurites fordii Hemsl. shell and Calx is 10-22: 18-22: 5-9, contains crude drug 40-55g in this disinfectant of every 100ml.
3, the preparation method of the described Chinese medicine antiseptic of claim 1 is characterized in that floral leaf decocting is gone into floral leaf decocting liquid with the Calx that sieves behind the Aleurites fordii Hemsl. shell ashing, promptly after filtering.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94113162A CN1050758C (en) | 1994-12-05 | 1994-12-05 | Traditional Chinese medicine sterilizing agent and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94113162A CN1050758C (en) | 1994-12-05 | 1994-12-05 | Traditional Chinese medicine sterilizing agent and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1124149A true CN1124149A (en) | 1996-06-12 |
| CN1050758C CN1050758C (en) | 2000-03-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94113162A Expired - Fee Related CN1050758C (en) | 1994-12-05 | 1994-12-05 | Traditional Chinese medicine sterilizing agent and its preparing method |
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| CN (1) | CN1050758C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007054502A3 (en) * | 2005-11-14 | 2007-09-07 | Hannah W Dahlheim | Method and agent for controlling microorganisms and bacteria |
| CN104488980A (en) * | 2014-12-10 | 2015-04-08 | 李怀生 | Traditional Chinese medicinal spray for sterilization and disinfection in hospitals |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031026A (en) * | 1987-08-05 | 1989-02-15 | 北京师范大学 | Make the compositions and the application thereof of sterilized sanitary accessories |
| CN1044759A (en) * | 1990-02-12 | 1990-08-22 | 祝原铮 | Nine-function liquid |
-
1994
- 1994-12-05 CN CN94113162A patent/CN1050758C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007054502A3 (en) * | 2005-11-14 | 2007-09-07 | Hannah W Dahlheim | Method and agent for controlling microorganisms and bacteria |
| CN104488980A (en) * | 2014-12-10 | 2015-04-08 | 李怀生 | Traditional Chinese medicinal spray for sterilization and disinfection in hospitals |
| CN104488980B (en) * | 2014-12-10 | 2017-07-11 | 李怀生 | A kind of Traditional Chinese medicinal spray for hospital's sterilizing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1050758C (en) | 2000-03-29 |
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