CN1076613C

CN1076613C - Skin-cleaning sterilizing agent (Ziguang oil)

Info

Publication number: CN1076613C
Application number: CN98113044A
Authority: CN
Inventors: 曹志光
Original assignee: Individual
Current assignee: Individual
Priority date: 1998-12-11
Filing date: 1998-12-11
Publication date: 2001-12-26
Anticipated expiration: 2018-12-11
Also published as: CN1256927A

Abstract

The present invention relates to a skin-cleaning sterilizing agent, namely Ziguang oil, which is prepared from eleven traditional Chinese medicines of coptis, phellodendron bark, baical skullcap root, giant knotweed rhizome, red sage root, red peony root, prism tuber, dahurian angelica, arnebia root, dragon's blood and borneol and vegetable oil as a matrix. The skin-cleaning sterilizing agent has the purposes of improving the blood circulation of burned area, resisting infection and increasing immunity, and has the functions of clearing away heat, removing toxic materials, resisting bacteria, relieving inflammation, dispelling stasis, invigorating pulse-beat, promoting tissue regeneration and nourishing skin; the skin-cleaning sterilizing agent has no toxicity and no stimulation, and can moisten wounds and promote wound healing; therefore, the present invention is an ideal skin sterilizing medicine for the nursing, the disinfection and the infection prevention of burn wounds.

Description

A kind of medicament for the treatment of burn and scald

The present invention relates to a kind of medicament for the treatment of burn and scald, the sterilization, sterilization, the infection that are mainly used in human skin tissue burn, scald, electric arc burn, chemical burn wound surface are handled.

Though the medicament of in the prior art burn wound being disinfected is a lot, and prescription is different, but mainly to improve the sanguimotor state of burn area, infection, improving immunocompetence is that purpose is selected the medicine prescription, thereby reach the effect that heat-clearing and toxin-vanquishing, anti-inflammation, blood stasis dispelling are promoted blood circulation, granulation promoting is grown skin, the medicament of accelerating wound healing yet there are no report so far.

The object of the present invention is to provide a kind of medicament for the treatment of burn and scald, it is to improve the sanguimotor state of burn area, infection, improving immunocompetence is that purpose is selected the medicine prescription, thereby reach the effect that heat-clearing and toxin-vanquishing, anti-inflammation, blood stasis dispelling are promoted blood circulation, granulation promoting is grown skin, accelerating wound healing, is the comparatively ideal skin degerming medicament of burn wound's nursing, sterilization, prevention infection.

Prescription foundation of the present invention: the modern medicine pathological research shows: burn is early stage, skin histology is subjected to the infringement of thermal source, temperature surpasses human body temperature more than 60 ℃, just easily causes the thermal source infringement, wounded tissue center blood capillary obstruction, ischemia, organize pale, be the coagulation necrosis district; Organize capillary blood flow slow outside this district, tissue is purple dark, is stasis of blood dead zone; The wounded tissue marginal area, capillary injection, skin histology is rubescent, is the hyperemia district.According to this pathological manifestations, the pathological change that confirms the burn position mainly is that the capillary blood circulation changes, thereby improves the sanguimotor state of burn area, is the fundamental means of treatment.After injured 72 hours, the injured area tissue is because of ischemia, anoxia, and antibacterial is invaded, and mainly is staphylococcus aureus, escherichia coli, candidiasis, prismatic bacillus cereus, bacillus pyocyaneus and virus etc., endocrine change, immunity reaction, and organize mummification necrosis or septic necrosis, the solid type of changing into of this tissue morphology changes, thereby infection, improves the another important means of immunocompetence for the treatment burn.Motherland's medical science is thought " the fire-toxin blood stasis injures skin " " the burnt roulade of skin, painful hard to bear " (" surgery opens profound "); This viewpoint and modern medicine micro-cycle theory match.According to above-mentioned Chinese and western medicine theory and clinical practice, set up the academic thought of " heat-clearing and toxin-vanquishing, blood stasis dispelling are promoted blood circulation, granulation promoting grow skin ", and founded the medication theoretical basis of purple light oil.

Chinese herbal medicine and vegetable oil are formed simply by ten in the present invention.Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae have heat-clearing and toxic substances removing, antibacterial action; Modern pharmacological research proves: antibacterial such as staphylococcus aureus, escherichia coli, bacillus pyocyaneus, modification bacillus and dermatophytes and virus are had very strong antibacterial action, can prevent and kill and suppress burn wound's bacterial infection; Rhizoma Polygoni Cuspidati, heat-clearing and toxin-vanquishing, promoting blood circulation and stopping pain, modern study has the strong antibiotic effect to antibacterials such as staphylococcus aureus, Bacillus proteus, bacillus cereuss; Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, rhizoma sparganic blood circulation promoting and blood stasis dispelling, stasis-dispelling and pain-killing, granulation promoting relieves internal heat, modern study, Radix Salviae Miltiorrhizae contain TANSHINONES, protocatechualdehyde, vitamin E, and Radix Paeoniae Rubra contains Radix Paeoniae Rubra glucoside, cachou extract, rhizoma sparganic contains rhizoma sparganic glycoside, choline, three flavor use in conjunction have good expander effect to blood capillary and trunk, and microcirculation improvement has analgesia, antiinflammatory and promoting muscle growth functions simultaneously; Radix Arnebiae (Radix Lithospermi) is invigorated blood circulation, removing heat from blood, antiinflammatory, Radix Angelicae Dahuricae longue skin, moist color, and modern study has anti-inflammation, analgesic effect; Sanguis Draxonis promoting blood circulation and stopping pain, convergence wound, modern study have the blood vessel of expansion, antithrombotic, acceleration blood flow, analgesic effect; The analgesia of Borneolum Syntheticum removing heat from blood, erosion prevention and muscle growing; Vegetable oil is concocted all medicines, the skin moistening granulation promoting.The full side of comprehensive above-mentioned branch folding has heat-clearing and toxin-vanquishing, anti-inflammation, blood stasis dispelling is promoted blood circulation, granulation promoting is grown skin effect, is the comparatively ideal skin degerming medicament of burn wound's nursing, sterilization, prevention infection.

Technical scheme of the present invention is:

1. material medicine is formed (weight ratio): Rhizoma Coptidis 40～60, Cortex Phellodendri 30～55, Radix Scutellariae 30～55, Rhizoma Polygoni Cuspidati 40～60, Radix Salviae Miltiorrhizae 45～60, Radix Paeoniae Rubra 45～60, rhizoma sparganic 45～55, the Radix Angelicae Dahuricae 15～30, Radix Arnebiae (Radix Lithospermi) 45～55, Sanguis Draxonis 15～35, Borneolum Syntheticum 50～65;

2. the w/v of material medicine gross weight and substrate vegetable oil is 1: 2;

3. preparation method: press material medicine and form all medicines of apolegamy, get required vegetable oil ready, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, rhizoma sparganic, the Radix Angelicae Dahuricae are immersed in the vegetable oil 48 hours, the slow fire frying is to sallow then, temperature is 80 ℃～100 ℃, leach medicinal residues, it is fried to sallow to put into purple simple shear again, 100 ℃ of temperature, put into the Sanguis Draxonis and the Borneolum Syntheticum of porphyrize after the filtration, reheat to the oil after-filtration that boils, temperature is 100 ℃, be collected in container after packing get final product.

Advantage that the present invention has and effect:

1, the present invention is the fundamental means of treatment to improve the sanguimotor state of burn area, with infection, improve immunocompetence and select the medicine prescription for another important means of treatment, has the effect that heat-clearing and toxin-vanquishing, anti-inflammation, blood stasis dispelling are promoted blood circulation, granulation promoting is grown skin, wound surface to human skin tissue burn, scald, electric arc burn, chemical burn has good sterilization, sterilization, anti-infectious function, and it is nontoxic, non-stimulated, can keep wound surface moistening, accelerating wound healing, is the comparatively ideal skin degerming medicament of burn wound's nursing, sterilization, prevention infection.

2, the present invention is through the evaluation assay (seeing adnexa for details) of Shaanxi Province health and epidemic prevention station:

(1), the former powder of the present invention (going to replenish the substrate amount with distilled water after the substrate) puts under 53-57 ℃ of conditions and stores 14 days, acts on the 120 minutes killing rate to staphylococcus aureus (ATCC6538) 〉=99.90%.

(2), carrier quantitation disinfection test result: stock solution and 50% mass action 120 minutes to the killing rates of staphylococcus aureus (ATCC6538) and escherichia coli (8099) all greater than 99.90%.Stock solution and 50% mass action 120 minutes to the killing rate of the staphylococcus aureus (ATCC6538) that contains the protection of 25% Organic substance all greater than 99.90%.

(3), on-site disinfection test result: smearing people's right forearm skin with stock solution of the present invention, act on 10 minutes, is 90.69% to the killing rate of skin surface natural bacteria.

(4), white mice acute oral toxicity test result is LD ₅₀〉=5000mg/kg body weight, true border nontoxic level disinfectant; Mucous membrane irritation result is: the present invention is to the mucosa nonirritant.

3, the clinical 200 example treatments of the present invention are summed up:

(1), physical data:

In the 95 annual 200 routine case histories, male 128 people, women 72 people, 0-5 years old ages, 36 examples, 6-16 years old 38 example, 17-45 years old 117 example, 9 examples more than 46 years old.Cause of disease classification: boiled water, meal soup 134 examples, account for 67%, ironware 13 examples account for 6.5%, and steam 10 examples account for 5%, gasoline and other oily 15 examples account for 7.5%, and bavin, charcoal fire 15 examples account for 7.5%, electric arc 5 examples, account for 2.5%, oxygen and other 2 example account for 1%, and soda acid chemistry 6 examples account for 3%.

(2), therapeutic outcome:

This organizes 200 examples, and wherein 10% area II degree-III degree 168 examples were treated total natural law 1368 days, mean treatment natural law 8.14 days; 11-30% area II degree-III degree 23 examples was treated total natural law 297 days, mean treatment natural law 13 days; 31% above area II degree-III degree 9 examples were treated total natural law 193 days, mean treatment natural law 21.4 days.

200 examples are cured among the patient, and mottle and cicatrix are sent out survivor's 6 examples, account for 3%.

The embodiment of the invention 1,2,3:

1, proportioning raw materials:

Raw material embodiment 1 embodiment 2 embodiment 3

Rhizoma Coptidis 40g 55g 60g

Cortex Phellodendri 30g 45g 55g

Radix Scutellariae 30g 45g 55g

Rhizoma Polygoni Cuspidati 40g 55g 60g

Radix Salviae Miltiorrhizae 45g 55g 60g

Radix Paeoniae Rubra 45g 55g 60g

Rhizoma sparganic 45g 50g 55g

Radix Angelicae Dahuricae 15g 25g 30g

Radix Arnebiae (Radix Lithospermi) 45g 50g 55g

Sanguis Draxonis 15g 30g 35g

Borneolum Syntheticum 50g 55g 65g

Vegetable oil 800m1 1040ml 1180ml

2, preparation method: press the selected all medicines of composition of raw materials, get required vegetable oil ready, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, rhizoma sparganic, the Radix Angelicae Dahuricae are immersed in the vegetable oil 48 hours, the slow fire frying is to sallow then, temperature is 80 ℃～100 ℃, leach medicinal residues, put into again Radix Arnebiae (Radix Lithospermi) cut fried to sallow, 100 ℃ of temperature, put into the Sanguis Draxonis and the Borneolum Syntheticum of porphyrize after the filtration, reheat to the oil after-filtration that boils, temperature is 100 ℃, be collected in container after packing get final product.

3, the scope of application

The present invention is exclusively used in the oil preparation disinfectant that burn wound disinfects.Having heat-clearing and toxin-vanquishing, anti-inflammation, the effect of granulation promoting taste skin, is good burn infection, accelerates

The medicament of wound healing.

4, using method:

(1), burn wound's skin is coated with every day 3～4 times outward.

(2), can expose wound surface and be coated with outward, also available aseptic dressing soaks into sliver to be wrapped up in burn wound, the next day, change dressings once, until recovery from illness.

5, points for attention:

(1), this product is pure Chinese medicinal preparation, no side effects.

(2), please don't mix application with other medicine, as using other medicine, available disinfectant solution cleaning back this preparation of reuse.

(3), extensive deep burn, need that to be used effect better with anti-infective therapy.

Claims

1, a kind of medicament for the treatment of burn and scald is characterized in that this medicament is that material medicine by the following weight ratio is prepared from as follows:

1. material medicine is formed: Rhizoma Coptidis 40～60, Cortex Phellodendri 30～55, Radix Scutellariae 30～55, Rhizoma Polygoni Cuspidati 40～60, Radix Salviae Miltiorrhizae 45～60, Radix Paeoniae Rubra 45～60, rhizoma sparganic 45～55, the Radix Angelicae Dahuricae 15～30, Radix Arnebiae (Radix Lithospermi) 45～55, Sanguis Draxonis 15～35, Borneolum Syntheticum 50～65;

3. preparation method: press material medicine and form all medicines of apolegamy, get required vegetable oil ready, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, rhizoma sparganic, the Radix Angelicae Dahuricae are immersed in the vegetable oil 48 hours, the slow fire frying is to sallow then, temperature is 80 ℃～100 ℃, leach medicinal residues, put into again Radix Arnebiae (Radix Lithospermi) cut fried to sallow, 100 ℃ of temperature, put into the Sanguis Draxonis and the Borneolum Syntheticum of porphyrize after the filtration, reheat to the oil after-filtration that boils, temperature is 100 ℃, be collected in container after packing get final product.